Corporate presentation

Arene Life SciencesLimited ‐ About us

Established In the year 2004 as API & Intermediatemanufacturerscateringto Indian market under S.R. Group of companies which started in 1993. Upgraded & Updated In the year2016 with focus to manufactureAPIs for global markets Manufacturing support

3 facilities – 1 functional API facility, 1 greenfield API facility & 1 KSM & intermediate manufacturing site. Group facilities include intermediates, fine chemical manufacturing & solvent recovery Current man power 750 in the group & 500 in API & intermediatesdivision

Sales Turnover (Pharmaceutical Division) Financials 2015‐16 – USD 15 Million 100% privately heldcompany 2016‐17 – USD 16 Million 2017‐18 – USD 33 Million Total group turnover USD 100 million 2018‐19 – USD 45 Million in 2018-2019

(Confidential) 2 Corporate Overview

Arene Lifesciences Limited (Unit 1) Established in : 2004 (Upgraded in 2016) DUNS / FEI :Will be applied in June 2019 Unit location : Pashamylaram Product Portfolio : APIs and Intermediates Total Area : 20,613 Sq. Mtrs Built up Area : 8,433 Sq. Mtrs Reaction Volume : 246 KL Arene Lifesciences Limited (Unit 2) Established in : 2016 (Green field project‐ Phase 1 completed) DUNS / FEI : Will be applied in June 2019 Unit location : Veliminedu, Chotuppal Product Portfolio : APIs and Intermediates Total Area : 40,468 Sq. Mtrs Built up Area : 24,280 Sq. Mtrs Reaction Volume : 604 KL AVR Organics Pvt Ltd (Arene ‐ Unit3) Established in : 2006 DUNS / FEI : Under Process Unit location : Sadasivpet Product Portfolio : KSMs and Intermediates Total Area : 424,919 Sq. Mtrs Built up Area : 18,257 Sq. Mtrs Reaction Volume : 240 KL

(Confidential) 3 Regulatory inspections & Filing

Q7 ‐ as workingphilosophy US DMF for & ScheduleM Efavirenz – 032188 Drug Control Administration Certified for Phthaloyl Amlodipine – 031674 Good Manufacturing Practices as stipulated Amlodipine Besylate -033873 under the provisions of Schedule “M” of Drugs and Cosmetics Rules,1945. CEP with EDQM Amlodipine Besylate 2018‐010 cGMP by Local WHO(DCGI) WHO ‐PQ Abacavir Sulphate Efavirenz Efavirenz – APIMF 347 Amlodipine Besylate Ritonavir Dolutegravir – U/Process Darunavir Lopinavir Emtricitabine ClopidogrelBisulphate Registrations in Russia Gabapentin Atazanavir Sulphate Saquinavir Mesylate Fluconazole MPP Licenses Valganciclovir Hcl S‐Amlodipine Besylate Dolutegravir, COBI, Elvitegravir Bictegravir, TAF, LOPI & RITO

(Confidential) 4 APIs - General

Product Therapeutic category Tech DMF Pack

Amlodipine Besylate EP/IP/USP Antihypertensive ✔ ✔

(S)-Amlodipine Besylate IH/IP Antihypertensive ✔ ✔

Clopidogrel Bisulphate IP/USP Anti-platelet ✔

Gabapentin USP/EP Anti-convulsant ✔ ✔

Levetiracetam Anti-convulsant ✔

Losartan Potassium IP/USP Cardiovascular ✔

Nadolol USP Cardiovascular ✔

Pregabalin IH CNS ✔

Tapentadol HCl Analgesics ✔

Trazodone Antidepressant ✔

Valganciclovir Hydrochloride USP Antiviral ✔ ✔

Valsartan USP/EP Cardiovascular ✔

(Confidential) 5 APIs – Anti Retrovirals

Product Therapeutic category Tech DMF Pack Abacavir Sulfate USP/EP Antiretroviral ✔ ✔ Darunavir IH Antiretroviral ✔ ✔ Dolutegravir Sodium IH Antiretroviral ✔ ✔ Efavirenz USP Antiretroviral ✔ Emtricitabine IH/IP Antiretroviral ✔ ✔ Etraverine Antiretroviral ✔ ✔ Fosamprenavir Calcium Antiretroviral ✔ Lopinavir USP Antiretroviral ✔ Nevirapine USP Antiretroviral ✔ Oseltamivir Phosphate Antiretroviral ✔ Raltegravir Potassium Antiretroviral ✔ Ritonavir USP Antiretroviral ✔ Saquinavir Mesylate USP/EP Antiretroviral ✔ ✔ Tenofovir Disoproxil Fumarate IH/IP Antiretroviral ✔

(Confidential) 6 APIs(General & ARVs) – Pilot Scale

Product Therapeutic category Tech DMF Pack

Bedaquiline Fumarate Anti Tuberculosis ✔

Daclatasvir IH Hepatitis C Virus Inhibitor ✔

FimasartanPotassium Antihypertensive ✔

Gemcitabine Anti Cancer ✔

Gliquidone Anti diabetic ✔

Olmesartan Medoxomil Anti Hypertensive ✔

Pemetrexed Anti Metabolite ✔

Rilpivirine HCl IH Antiretroviral ✔

Tenofovir Alafenamide Fumarate Antiretroviral ✔

(Confidential) 7 Intermediates

Chemical Name CAS #

Amlodipine Besylate :

N-(2-Hydroxyethyl)phthalimide 3891-07-4

Ethyl-4 {(2-Phthalimido) Ethoxy} Acetoacetate 88150-75-8

Pthaloyl Amlodipine 88150-62-3

Amlodipine Base 88150-47-4

Clopidogrel Bi sulphate:

Coupled Amine Hydrochloride 141109-19-5

(Confidential) 8 Multi product productionblocks built in compliance with WHO – GMP norms with world class technology in eco – friendly environment manned by a team of dedicated andexperienced professionals.

Reaction Capabilities Our sites are equipped with Grignard Reaction Bromination Reactors from ATFDs,RCVDs, Chlorination SodiumHydride VTDs, TDs, Hydrogenation Nitration 20 L to 7KL Oxidation Amination FBDs,ANFDs, Friedel‐CraftReaction Esterification

(Confidential) 9 Our customers benefit from Our far‐reaching expertise in advanced analytical techniques and processes, supported by industry‐leading ICH guidelines& GMP practices. Product knowledge. We develop advancedanalytical methods and specifications suitable for the routes of synthesis and crystallization of ourAPIs.

Regulatory compliance. We have the technical know‐how and experience to support ever‐evolving regulatory requirements.

Professional support. We provide our colleagues and customers with state‐of‐the‐art scientificsupport for API development andproduction.

Powder processing. Our experts excel in tailoring physical properties to customer requirements. We specialize in polymorphic forms and other bulk physical properties designed to meet your special formulation needs

(Confidential) 10 Our Quality Commitment Uncompromising and we demonstrate itby: Empower software • Complying with current GoodManufacturing Practice (GMP) standards 21 CFRcompliant HPLCs GCs • Conducting regular internal and externalaudits of our manufacturing sites cGLPcompliant • Undergoing regular inspections by health authorities and customers. These inspections keep us at high GMP compliance standards at all times

• Implementing continual quality improvement initiatives according to emerging industrytrends

• Enforcing rigorous end‐to‐end control. We All zones stabilitychambers ensure our suppliers comply with quality Microbiology lab regulations and standards throughperiodic audits of theirfacilities. (Confidential) 11 Site information

Arene Lifesciences Limited Unit‐1

(Confidential) 12 Plant overview

6 Manufacturing Blocks Cumulative Volume of Reactors: 246KL (includes Glass lined &Stainless Steel Reactors)

Area of theFactory: Total : 20,613Sq.Mtrs Built up : 8,433Sq.Mtrs Green Belt : 2,675Sq.Mtrs Aerial view of Unit1

(Confidential) 13 Site information Location 55 Km from InternationalAirport

PhysicalAddress Arene Life Sciences Limited, Unit‐I. Plot No: 48, 49, 50, 209, 210 & 211, Phase‐ II, IDA Pashamylaram, Patancheru (M), (Dist), 502307 Telangana,India. Tel. :08455‐297970 Fax:08455‐241374 Established Facility operation Hours: In 2004 under CompaniesAct, 1956 Facility operates in 3 shiftsA, B, C and Engaged in manufacture & Export of Active General Shift. Pharmaceutical Ingredients (APIs) and Drug Business hours 9:00 to 17:30Hours. Intermediates

(Confidential) 14 Satellite image ‐Google

IDA Co‐ordinates 17°32' 22.2648‘’N 78°10' 49.4796‘’E

(Confidential) 15 Drone image

(Confidential) 16 Aerial view of unit1

(Confidential) 17 Unit 1

(Confidential) 18 Site history

Take over in 2004 from Jaysynth Drugs & Pharmaceuticals Limited

Established in 2004 under Companies Act, 1956 as ARENE Lifesciences Limited which is part of SRGroup.

Re‐focused towards exports into global marketsthus upgrading the facility since2016.

API DMFfiling started in October 2017

(Confidential) 19 Man Powerdetails

R&D Production QA Warehouse 110 18 8 26 Total :253*

QC & HR & EHS Maintenance SupportingServices Microbiology 8 36 37 7

* As on April-2018

(Confidential) 20 Quality Control Equipment

S. Number of Instrument Name No. Instruments 1 HPLC Ten 2 GC Five 3 KF Two 4 Auto Titrator Three 5 FTIR Two 6 UV One 7 Hot airoven Two 8 Muffle furnace One 9 pH meter Four 10 Microbalance One 11 Semi Micro Balance Three 12 Incubator Three 13 Auto clave Two 14 Polari meter One 15 IR MoistureAnalyser One 16 Tapped DensityApparatus One 17 Conductivity Meter One 18 Biological safetyCabinet One 19 LAF Two 20 TOC Analyser One

(Confidential) 21 Utilities

 Compressed air system

 Nitrogen plant Purified water plant 5.0KL/hr Boiler 1 2.0 Ton/hr  UPS Boiler 2 3.0 Ton/hr Brine chilling plant 42 TR at ‐20°C  Adequate power Backup (100%) Brine chilling plant (3 Nos) 40 TR at ‐15°C Brine chilling plant 20 TR at ‐15°C  Chilling plant Nitrogen plant 20 nm³/hr Nitrogen plant 40 nm³/hr Air compressor (2 Nos) 90 CFM  Steam generation Vacuum pumps (4 Nos) 200 m³/hr High Vacuum pumps (15Nos) 300 m³/hr  Hot oilsystem Multiple Evaporator 50,000 L/Day

 Cooling tower

(Confidential) 22 Utilities

Water Purification System

 Water system consists of RO plant followed by purified water treatment.

 Water distribution to the Manufacturing Blocks with closed circulating Loop System.

 Water Quality meets to pharmacopeia Purified water requirements.

Pharma Areas (API Isolation and Powder processing/Finalpacking)

 Adequate AHUs for relevant areas with HEPAfilters.  Each Block has separate pharma section. Pharma areas are controlled and monitored as class100,000.

(Confidential) 23 Quality Management System

 Vendor Approval andEvaluation  Qualifications  Validations  Training  Documentation and RecordsControl  ChangeControls  Deviations  OOS, OOT, Investigation & CAPA  Stability ProgramManagement  Complaints andRecalls  Returns  InternalAudits  Quality RiskManagement  APQR  Management Review  Pest Control

(Confidential) 24 Quality Policy & EHSPolicy

Quality Policy

Arene Lifesciences Limited is committed to achieve high standards in quality of products & services in order to satisfy its customers and exceed their expectation levels across theglobe;

Constantly explore the opportunities in upgrading its manufacturing capabilities, technologies and quality standards to achieve and maintain quality leadership with thrust on eco‐friendlyprocesses.

Strive to create a cohesive and motivated team of international competency by providing a healthy working environment and periodic training to enhance the team’s knowledge and skills continuously.

Ensure compliance to the national and international regulatorystandards

EHS Arene Life Sciences is committed to protect Policy the Environment, Health and Safety of our employees, customers and the global communities where we operate.

(Confidential) 25 Thank you

MANUFACTURING UNITS:

Arene Life Sciences Limited ‐ Unit 1 Plot No: 48, 49, 50, 209, 210 &211, Phase‐ II, IDA, MARKETING OFFICE 3rd Floor, Plot No. 122, Kavuri Hills, Phase 1, Madhapur, Pashamylaram, Patancheru (M), (D), ‐ 500 033, Telangana,India, Telangana, India. Tele: + 91 40 49513270 Fax: 08455 ‐ 241374, e‐mail:[email protected] Arene Life Sciences Limited ‐ Unit 2 Survey Nos 412/A, Veliminedu Village, CORPORATE OFFICE Chityala (M) (D), Telangana,India. #3 ‐ 58, S. R. Chambers,Ramachandrapuram, Hyderabad ‐ 502 032, Telangana,India, Arene Life Sciences Ltd. (AVR Organics Pvt Ltd) – Unit 3 Tele: 08455 ‐ 241148, 285730, 244489. Survey Nos 12 & 13, Yavapur, Road, Fax: 08455 ‐ 241374, e‐mail:[email protected] Sadasivpet, Medak (D), Telangana, India.

(Confidential) 26