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Methysergide Maleate

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Methysergide Maleate Methysergide maleate sc-204081 Material Safety Data Sheet Hazard Alert Code EXTREME HIGH MODERATE LOW Key: Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Methysergide maleate STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY1 HEALTH2 HAZARD INSTABILITY0 SUPPLIER Company: Santa Cruz Biotechnology, Inc. Address: 2145 Delaware Ave Santa Cruz, CA 95060 Telephone: 800.457.3801 or 831.457.3800 Emergency Tel: CHEMWATCH: From within the US and Canada: 877-715-9305 Emergency Tel: From outside the US and Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 PRODUCT USE Used as a prophylactic agent in the management of severe recurrent migraine; ineffective against acute attacks of migraine. Also used to control diarrhoea associated with carcinoid disease. A potent serotonin antagonist; compared with ergotamine it has only a weak vasoconstrictor and oxytocic effect. SYNONYMS C21-H27-N3-O2.C4-H4-O4, "ergolina-8beta-carboxamide, 9, 10-didehydro-N-[1-(hydroxymethyl)propyl]-", "ergolina-8beta- carboxamide, 9, 10-didehydro-N-[1-(hydroxymethyl)propyl]-", "1, 6-dimethyl-, maleate (1:1) (salt)", "1, 6-dimethyl-, maleate (1:1) (salt)", "1-(hydroxymethyl)propylamide of 1-methyl-(+)-lysergic acid hydrogen", "1-(hydroxymethyl)propylamide of 1- methyl-(+)-lysergic acid hydrogen", maleate, "lysergamide, N-[(1-hydroxymethyl)propyl]-1-methyl-, maleate", "lysergamide, N- [(1-hydroxymethyl)propyl]-1-methyl-, maleate", "1-methyl-D-lysergic acid butanolamide maleate", "1-methyl-D-lysergic acid butanolamide maleate", "9, 10-didehydro-N-[(1-(hydroxymethyl)propyl]-1-, 6-dimethylergoline-", "9, 10-didehydro-N-[(1- (hydroxymethyl)propyl]-1-, 6-dimethylergoline-", "8beta-carboxamide hydrogen maleate", "methysergide bimaleate", "methysergide dimaleate", "methsergide (sic) hydrogen maleate", Deseril-Retard, Desernil, Sansert, "ergot alkaloid" Section 2 - HAZARDS IDENTIFICATION CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW RISK Harmful if swallowed. May cause harm to the unborn child. Possible risk of impaired fertility. Irritating to eyes, respiratory system and skin. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ■ Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. ■ Limited evidence exists that the substance may cause irreversible but non-lethal mutagenic effects following a single exposure. ■ The ergot alkaloids are a group of biogenic amines which act as agonists on alpha-type adrenergic receptors. Symptoms of acute poisoning due to ergot are attributable to central system stimulation and include nausea, vomiting, diarrhoea, thirst, coldness of the skin, pruritus, weak pulse, numbness and tingling of the extremities, tachycardia, mydriasis, confusion and unconsciousness. Certain factors may predispose individuals to ergotism - these may include Vitamin A and/or C deficiency, malnutrition, hepatic and renal disease and sepsis. Consumption of contaminated grain and grain products, containing ergot alkaloids, has produced poisoning of epidemic proportions and still occurs. Intense peripheral vasoconstriction of the extremities may produce gangrene and has inspired the name "St. Anthony's fire". Two forms of epidemic toxicity have been described - these rarely occur together. A gangrenous form is characterised by agonising pain in the extremities followed by dry gangrene of the peripheral parts. Initial signs and symptoms include calf pain, cool extremities and paraesthesias (especially of the extremities). Anginal pain may be elicited in those with coronary insufficiency. Foot drop and transient monocular blindness may also occur. A rarer nervous type of epidemic toxicity described as "convulsive syndrome" gives rise to paroxysmal eleptiform convulsions. Other symptoms include vertigo, headache, tinnitus, sensual disturbances, hallucinations, muscle spasm, gastrointestinal upset and convulsions. Ergotamine, a member of the group, is a potent oxytocic, producing abortion or foetal harm in pregnant women. In large repeated doses ergotamine produces all the symptoms of ergot poisoning; fatalities have occurred. Different ergot alkaloids and their derivatives have varying degrees of alpha-adrenergic blocking activity; dihydrogenated alkaloids are potent blocking agents while compounds which lack a polypeptide side-chain in their structure possess little activity. However, it is now accepted that the varied and complex pharmacology of these alkaloids derives from their actions as partial agonists and antagonists at dopamine and serotonin receptors as well as alpha-adrenoreceptors. The most important effects are due to actions on the central nervous system and direct stimulation of the smooth muscle of the uterus and blood vessels. Differences between individual compounds may be, in part, due to varying effects at different receptors whilst the range of effects may also be dose-dependent; the physiological state of the individual may also be a factor the expression of these effects. NOTE: The levo-isomer of the ergot alkaloids (names ending in "ine" versus "inine") is generally the highly active form. EYE ■ This material can cause eye irritation and damage in some persons. SKIN ■ This material can cause inflammation of the skin oncontact in some persons. ■ The material may accentuate any pre-existing dermatitis condition. ■ Skin contact with the material may damage the health of the individual; systemic effects may result following absorption. ■ Open cuts, abraded or irritated skin should not be exposed to this material. ■ Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. INHALED ■ The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage. ■ Inhalation of dusts, generated by the material during the course of normal handling, may be damaging to the health of the individual. ■ Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. ■ Limited evidence exists that the substance may cause irreversible but non-lethal mutagenic effects following a single exposure. CHRONIC HEALTH EFFECTS ■ Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems. Ample evidence exists, from results in experimentation, that developmental disorders are directly caused by human exposure to the material. Ample evidence from experiments exists that there is a suspicionthis material directly reduces fertility. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. Exposure to the material may result in a possible risk of irreversible effects. The material may produce mutagenic effects in man. This concern is raised, generally, on the basis of appropriate studies with similar materials using mammalian somatic cells in vivo. Such findings are often supported by positive results from in vitro mutagenicity studies. Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray. Chronic "ergotism" (resulting from therapeutic overdose) produces circulatory disturbances due to vasoconstriction and formation of thrombi. Initial symptoms include coldness of the skin, severe muscle pain, and vascular stasis resulting in dry peripheral gangrene. Anginal pain, bradycardia and hypotension or hypertension, may also occur. Other signs include headache, nausea, vomiting, diarrhoea, dizziness, weakness of the legs, miosis, confusion, drowsiness, paralysis of one side of the body (hemiplegia) and convulsions. Interaction with the 5-HT2B serotonin receptors of cardiac myocytes, may cause proliferative heart valve disease. Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS HAZARD RATINGS Min Max Flammability: 1 Toxicity: 2 Body Contact: 2 Min/Nil=0 Low=1 Reactivity: 1 Moderate=2 High=3 Chronic: 3 Extreme=4 NAME CAS RN % methysergide maleate 129-49-7 >98 Section 4 - FIRST AID MEASURES SWALLOWED ■ IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY. Where Medical attention is not immediately available or where the patient is more than 15 minutes from a hospital or unless instructed otherwise: For advice, contact a Poisons Information Center or a doctor. Urgent hospital treatment is likely to be needed. If conscious, give water to drink. INDUCE vomiting with fingers down the back of the throat, ONLY IF CONSCIOUS. Lean patient forward or place on left side (head-down position, if possible) to maintain open airway and prevent aspiration. NOTE: Wear a protective glove when inducing vomiting by mechanical means. In the mean time, qualified first-aid personnel should treat the patient following observation and employing supportive measures as indicated by the patient's condition. If the services of a medical officer or medical doctor are readily available, the patient should be placed in his/her care
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