DOCSLIB.ORG

[Thesis Title Goes Here]

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
[Thesis Title Goes Here] THE DEVELOPMENT AND IMPLEMENTATION OF HIGH- THROUGHPUT TOOLS FOR DISCOVERY AND CHARACTERIZATION OF PROTON EXCHANGE MEMBRANES A Dissertation Presented to The Academic Faculty by Keith Gregory Reed In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy in the School of Chemical and Biomolecular Engineering Georgia Institute of Technology December 2009 Copyright © 2009 by Keith Gregory Reed THE DEVELOPMENT AND IMPLEMENTATION OF HIGH- THROUGHPUT TOOLS FOR DISCOVERY AND CHARACTERIZATION OF PROTON EXCHANGE MEMBRANES Approved by: Dr. J. Carson Meredith, Advisor Dr. David Bucknall School of Chemical and Biomolecular School of School of Polymer, Textile & Engineering Fiber Engineering Georgia Institute of Technology Georgia Institute of Technology Dr. Tom Fuller Dr. Anselm Griffin School of Chemical and Biomolecular School of Polymer, Textile & Fiber Engineering Engineering Georgia Institute of Technology Georgia Institute of Technology Dr. William Koros School of Chemical and Biomolecular Engineering Georgia Institute of Technology Date Approved: October 9, 2009 I dedicate this work to my mother, whose wisdom and love have kept me pushing forward, and to my father, who I know is smiling down on me from heaven. Acknowledgements First and foremost, I must thank God for blessing me with the opportunity to have this experience. Through His love and favor, I have discovered the strength, the wisdom, and the confidence to make it this far. To my mom, for the morals and values that you have instilled upon me from a young age, I am truly grateful. To my little brother and sister, Kevin and Krisitn, I hope that my life’s journey thus far has encouraged you both to discover your passions in life, and that you remain focused in pursuing your dreams. To my Nana, you have always supported and encouraged my academic pursuits; and to Grandma, you have imparted so much wisdom upon me. I love you both so much and I am truly blessed to have you both in my life. I am especially grateful to my advisor, Dr. Carson Meredith, who gave me the opportunity to pursue my research interests and discover new ones. You have challenged my way of thinking while encouraging my progress. You pushed me to be creative yet critical in my work, and allowed me to really take ownership of this project. Your continuous support and guidance throughout my tenure at Georgia Tech has been invaluable. I am also extremely grateful to my research committee, who has shown genuine interest in my work and has given me valuable feedback throughout the years to improve my research. Your questions, your concerns, and your words of encouragement have motivated my development into a well-rounded, critical thinker. I’d like express my sincerest gratitude to Dr. Sue Ann Bidstrup-Allen, who gave me the opportunity to be more than just a graduate student, but a leader and role-model for other students. The opportunities that you have provided for me have made my Georgia Tech experience so unique. I’d also like to thank Dr. Lakeisha Taite, Dr. Keith Oden, and Dr. Comas Haynes, for showing interest in my academic progress and iv professional development. I look forward to passing along the knowledge and insight that you have bestowed upon me. I am truly grateful to the administrative staff in the ChBE Department , especially Ms. Brenda Maddox, Ms. Janice Whatley, Ms. Juanita Freeman, Ms. Phyllis Jones, Ms. Claudia Clarkson, Ms. Rochelle Moses and Ms. Josie Giles – with all of your assistance and encouragement, there was no issue that could not be easily resolved – thank you for taking care of me. I’d like to thank Dr. John Walsh, Dr. Chris Wieble, Dr. Valarie Thomas, and other faculty associated with the Ivan Allen School of Public Policy that I have had the pleasure of interacting with. You all have given me a great deal perspective on my work and allowed me to really grasp “the bigger picture” of my research. To those esteemed ChBE graduate alumni who have come before me: Dr. Akua Asa-Awuku, Dr. Joe Lahai-Sormana, Dr. Charlene Rincon, Dr. Pedro Zapata, Dr. Jing Su – for sharing your knowledge and experience with me, I am ever so grateful. Whether it was lab training, academic or non-academic guidance, or just a few laughs, you all have added much wisdom and enjoyment to my Georgia Tech experience. I can only hope that I have impacted others as you all have impacted me. I want to thank my incoming class of 2004 who has taken the journey with me, especially JR Johnson and Shara McClendon – you have both been great colleagues and amazing friends. To my Exxon Mobil mentees, both past and present: Tracie, Mallerie, Arlyne, Mayisha, Katrina, Namory, Charmaine, and Channel – encouraging your professional and academic development has also helped me to develop as person and I wish you all much success in your future endeavors. I’d like to acknowledge those students who aided me in my research efforts, especially Ryan Hart, Tori Blasucci, Hillary Huttenhower, Pamela Pollet, Ven Rajarathinam, and Cheng Chen, as well as the members of the Koros research group for generously allowing me to use their commercial resins. To Jung-Hyun Lee, for your amazing TGA and SEM work, for putting v in the extra late hours, and for offering your insight to my research, I am very grateful. Also to Ismael Gomez, I’m glad that I you decided to come to Tech and work with our group – the past two years have been a lot of fun. I know that you will accomplish great things both in and out of the lab, and I wish you much success as you continue through Tech. I also have to thank the Black Graduate Student Association and the crazy fast members of the Georgia Tech Runnin’ Wreck Running Club – you have encouraged me strive for the best in all facets of life and helped me to maintain the work-life balance that I so desperately needed throughout my time at Georgia Tech. Last but not least, I have to acknowledge the organizations that funded my research: the Department of Energy, Arkema, Inc., Honda, and Applied Materials. Also, I must thank the FACES organization, who not only provided financial support but also provided me with a wealth of insight into the world of academia. And to the rest of my family, friends, and colleagues, I am very grateful to have established fulfilling relationships with you all. vi Table of Contents Acknowledgements .......................................................................................................... iv List of Tables ................................................................................................................... xiii List of Figures .................................................................................................................. xiv Summary… ................................................................................................................... xviii Chapter 1: Introduction .................................................................................................. 1 1.1. Energy Sustainability .......................................................................................... 2 1.1.1. Energy Consumption ................................................................................... 2 1.1.2. Fossil Fuels ................................................................................................. 8 1.1.2.1. Foreign Dependence ............................................................................ 8 1.1.2.2. Natural Abundance ............................................................................. 10 1.1.2.3. Emissions ........................................................................................... 13 1.1.2.4. Extraction and Transportation ............................................................ 14 1.1.3. Alternative Energy Resources ................................................................... 15 1.1.3.1. Energy Storage, Transmission, and Conversion ................................ 17 1.2. Fuel Cells .......................................................................................................... 19 1.2.1. Phosphoric Acid Fuel Cells (PAFCs) ......................................................... 22 1.2.2. Alkaline Fuel Cells (AFCs) ......................................................................... 22 1.2.3. Molten Carbonate Fuel Cells (MCFC) ....................................................... 23 1.2.4. Solid Oxide Fuel Cells (SOFCs) ................................................................ 24 1.2.5. Proton Exchange Membrane Fuel Cells (PEMFCs) .................................. 24 1.3. Combinatorial Methods for Polymer Discovery ................................................. 26 1.3.1. Library Synthesis and Processing ............................................................. 27 1.3.2. High-Throughput Characterization ............................................................ 30 vii 1.3.2.1. Proton Conductivity and Mechanical Strength .................................... 30 1.3.2.2. Water Management ............................................................................ 31 1.4. Outline .............................................................................................................. 32 1.5. References ....................................................................................................... 34 Chapter 2: High-Throughput Mass Transport Characterization of Polymer Membranes .............................................................................. 38 2.1. Introduction ......................................................................................................
Load more

Recommended publications
  • Copyrighted Material
    Index Abbreviations receptor sites 202, 211 weak 122 amino acids, Table 500–1 muscarinic 413 weak, pH calculation 147–8 nucleic acids 551 nicotinic 413 Acid–base nucleotides, Table 551 as quaternary ammonium salt 202 catalysis, enzymes 516 peptides and proteins 504 Acetylcholinesterase equilibria 121 phosphates and diphosphates 277 enzyme mechanism 519–21 interactions, predicting 155–7 structural, Table 14 hydrolysis of acetylcholine 279 Acidic reagents, Table 157 ACE (angiotensin-converting enzyme) inhibitors 279 Acidity enzyme action 532 Acetyl-CoA carboxylase, in fatty acid acidity constant 122 inhibitors 532 biosynthesis 595 bond energy effects 125 Acetal Acetyl-CoA (acetyl coenzyme A) definition 121 in etoposide 233 as acylating agent 262 electronegativity effects 125 formation 229 carboxylation to malonyl-CoA 595, hybridization effects 128 polysaccharides as polyacetals 232 609 inductive effects 125–7 as protecting group 230 Claisen reaction 381 influence of electronic and structural Acetal and ketal enolate anions 373 features 125–34 cyclic, as protecting groups 481 in Krebs cycle 585 and leaving groups, Table 189 groups in sucrose 231 from β-oxidation of fatty acids 388 pKa values 122–5 Acetaldehyde, basicity 139 as thioester 262, 373 resonance / delocalization effects 129–34 Acetamide, basicity 139 Acetylene, bonding molecular orbitals 31 Acidity (compounds) Acetaminophen, see paracetamol Acetylenes, acidity 128 acetone 130 Acetoacetyl-CoA, biosynthesis from N-Acetylgalactosamine, in blood group acetonitrile 365 acetyl-CoA 392
    [Show full text]
  • Electrophilic Reagents-Recent Developments and Their Preparative Application
    Volume 19. Number 3 March 1980 Pages 1 5 1-230 International Edition in English Electrophilic Reagents-Recent Developments and Their Preparative Application By Franz Effenberger“] Dedicated to Professor Matthias Seefelder on the occasion of his 60th birthday The most widely known electrophilic agents are protic acids and compounds with an electron- sextet partial structure. Recent research has aimed at the development of new electrophilic rea- gents, with greater reactivity on the one hand and higher selectivity on the other, which would largely obviate the addition of Lewis acids (Friedel-Crafts catalysts), and also alIow control of the isomer ratio in reactions with ambivalent substrates. Compounds with “super-leaving groups”, such as trifluoromethanesulfonate and fluorosulfate, have been demonstrated as most advantageous in this respect since they are sufficiently polarized or dissociated for reactions to take place even in the absence of Friedel-Crafts catalysts. Heterocycles such as pyridones or imidazole are likewise suitable leaving groups; they are employed for their high selectivity, and also because they allow working under non-aqueous conditions. 1. Introduction The basic principle underlying the interaction between acid/base, acceptor/donor, and electrophile/nucleophile has The terms “electrophile” and “electrophilic reagent” were been a controversial issue for a long time, and has led to fre- introduced into organic chemistry by C. K. Ingold””l;his def- quent attempts at an optimum systematization or classifica- initions, given in a comprehensive review[‘b1and in his stan- tionr2].Zngold had already recognized clearly, though, that a dard work “Structure and Mechanism in Organic Chemis- formal (electric) charge is not prerequisite for the electrophil- try’’[tc1,are still valid today: icity of a certain species; rather, the actual electrophilic moiety may be formed in situ in the reactant mixture.
    [Show full text]
  • United States Patent (19) 11 Patent Number: 5,824,799 Buechler Et Al
    USOO5824799A United States Patent (19) 11 Patent Number: 5,824,799 Buechler et al. (45) Date of Patent: Oct. 20, 1998 54 HYBRD PHTHALOCYANNE DERVATIVES 932.3492 11/1993 WIPO. AND THEIR USES 9508772 3/1995 WIPO. (75) Inventors: Kenneth F. Buechler, San Diego; OTHER PUBLICATIONS Joseph B. Noar, Solana Beach; Lema Cerfontain and Kort, “Electrophilic Aromatic Sulfonation Tadesse, San Diego, all of Calif. with Acidic Sulfonating Reagent,” Int. J. Sulfur Chem. C6:123–136 (1971). 73) Assignee: Biosite Diagnostics Incorporated, San Cerfontain and Kort, Mechanistic Aspects in Aromatic Sul Diego, Calif. fonation and DeSulfonation, InterScience, New York, pp. 2–5, 68–79 and 121-126 (1968). Appl. No.: 620,597 Cook et al., “Octa-alkoxy Phthalocyanine and Naphthalo cyanine Derivatives: Dyes with Q-Band Absorption in the Filed: Mar 22, 1996 Far Red or Near Infrared,” J. Chem. Soc. Perkin Trans. I pp. 2453–2458 (1988). Related U.S. Application Data Eldred and Young, “Dichlorofumaric Acid,” J. Am. Chem. Continuation-in-part of Ser. No. 274,534, Jul. 12, 1994, and Soc. 75:4338-4339 (1953). a continuation-in-part of Ser. No. 138,708, Oct. 18, 1993, Förster, “Zwischenmolekulare Energiewanderung und Fluo abandoned, and a continuation-in-part of Ser. No. 126,367, reszenz,” Ann. Physik. 2:55-75 (1948). Sep. 24, 1993, abandoned, and a continuation-in-part of Ser. Gilbert, Sulfonation and Related Reactions, Interscience, No. 311,098, Sep. 23, 1994, and a continuation-in-part of New York, pp. 102–103,306–307 and 339–383 (1965). Ser. No. 409,825, Mar. 23, 1995. Gregoriadis (editor), Liposome Technology, Vol.
    [Show full text]
  • Novel Phenoxazine Dyes: Laccase-Mediated Synthesis, Physico-Chemical Properties and Applications
    Université catholique de Louvain Faculté des Sciences Unité de chimie organique et médicinale Promoteur: Prof. J. Marchand-Brynaert Novel Phenoxazine Dyes: Laccase-Mediated Synthesis, Physico-Chemical Properties and Applications February 2010 2 Members of the jury: Prof. J. F. GOHY (Université catholique de Louvain, president of the jury) Prof. G. IACAZIO (Laboratoire de Bioinorganique Structurale, Université Paul Cézanne-Aix-Marseille III, France) Prof. P. J. COURTOY (De Duve Institute, Université catholique de Louvain) Prof. J. MARCHAND-BRYNAERT (Université catholique de Louvain, supervisor) Prof. M. DEVILLERS (Université catholique de Louvain) Prof. B. ELIAS (Université catholique de Louvain) Prof. R. ROBIETTE (Université catholique de Louvain) 3 4 Acknowledgements This work would not have been possible without the support of many people. First of all I would like to thank my supervisor, Prof. J. Marchand-Brynaert, who welcomed me again, after 3 years of an insightful journey in the pharmaceutical industry, and gave me the opportunity to perform a research work in the extremely interesting and challenging domain of biocatalysis. Without her precious confidence, constant support and helpful guidelines, this work would have never seen neither the beginning nor the end. I have a special thought for the Dr. Sophie Vanhulle and for her family. Sophie Vanhulle, unfortunately deceased in September 2009, had a vision which resulted in the SOPHIED project that she initiated and in which she kindly welcomed me. Without this research project, this thesis would not have been possible. I also thank my committee members, Prof. Gohy, Prof. Iacazio, Prof. Devillers, Prof. Courtoy, Prof. Elias and the Prof. Robiette for the helpful suggestions.
    [Show full text]
  • Secondary Reactions and Partial Rate Factors in the Sulfonation of Chlorobenzene and Toluene
    Brigham Young University BYU ScholarsArchive Theses and Dissertations 1967-08-01 Secondary reactions and partial rate factors in the sulfonation of chlorobenzene and toluene Ernest Arthur Brown Brigham Young University - Provo Follow this and additional works at: https://scholarsarchive.byu.edu/etd BYU ScholarsArchive Citation Brown, Ernest Arthur, "Secondary reactions and partial rate factors in the sulfonation of chlorobenzene and toluene" (1967). Theses and Dissertations. 8178. https://scholarsarchive.byu.edu/etd/8178 This Dissertation is brought to you for free and open access by BYU ScholarsArchive. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of BYU ScholarsArchive. For more information, please contact [email protected], [email protected]. SECONDARYREACTIONS AND PARTIAL RATE FACTORS IN THESULFONATION OF CHLOROBENZENEAND TOLUENE 'Y \ I v A Dissertation Submitted to the Department of Chemistry Brigham Young University In Partial F'ulfillment of th~ Requirements for the Doctor of Philosophy Degree by Ernest A. Brown August, 1967 l -~ This dissertation, by Ernest A. Brown, is accepted in its present form by the Department of Chemistry of Brigham Young University as sati.sfying the dissertation requirement for the degree of Doctor of Philosophy" ii \,. ACKNOWLEDGMENTS I wisn to extend my appreciation to the faculty and staff of Brigham Young Unive:r.sity for the assistance given during the course of this work~ and to the U.S. Department of Health, Education 9 and Welfare for the N. D. E. A. fellowship which helped support me while this work was being done. A special thanks is extended to Dr. K. L. Nelson for his encouragement and assistance and for providing an atmosphere conducive to indepem,dent.
    [Show full text]
  • 15. Benzene and Aromaticity Aromatic Compounds
    15. Benzene and Aromaticity Aromatic Compounds Benzene is the parent of the family of aromatic compounds. Its six carbons lie in a plane in a hexagon, each carbon has one hydrogen attached. Benzene is a resonance hybrid of two Kekulé structures. Note: It’s okay to use circle representation if explicitly showing π electrons is not necessary, since circle doesn’t indicate number of π electrons in ring 2 Aromatic Compounds In orbital terms, each carbon is sp2-hybridized. These orbitals form σ bonds to hydrogen and the two neighboring carbons are all in the ring plane. A p orbital at each carbon is perpendicular to this plane, and the six electrons, one from each carbon, form an electron cloud of π bonds, which lie above and below the plane. The bond angles in benzene are 120. All CC bond distances are equal (1.39 Å). The compound is more stable than either of the contributing Kekulé structures and has a resonance or stabilization energy of about 36 kcal/mol. 3 Aromatic Compounds The origin of the term aromatic comes from the description of fragrant substances such as benzaldehyde present in cherries, peaches, and almonds. Benzaldehyde Today aromatic refers to benzene and its structural relatives. Many compounds synthetic and isolated from nature are aromatic in part, including estrone, morphine and Valium. 4 15.1 Sources of Aromatic Hydrocarbons Coal and petroleum are two main sources for simple aromatic compounds. Coal has an array of benzene like rings joined together and some compounds that coal tar yields are benzene, toluene, naphthalene, and xylene.
    [Show full text]
  • (ARYLENE ETHER SULFONE) COPOLYMERS Via DIRECT COPOLYMERIZATION: CANDIDATES for PROTON EXCHANGE MEMBRANE FUEL CELLS
    SYNTHESIS AND CHARACTERIZATION OF SULFONATED POLY (ARYLENE ETHER SULFONE) COPOLYMERS via DIRECT COPOLYMERIZATION: CANDIDATES for PROTON EXCHANGE MEMBRANE FUEL CELLS by William L Harrison Dissertation submitted to the Faculty and the Graduate School of the Virginia Polytechnic Institute and State University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in Chemistry APPROVED: Dr. James E. McGrath, Chairman Dr. John G. Dillard Dr. Judy S. Riffle Dr. Allan R. Shultz Dr. Godson C. Nwokogu, Hampton University, Va December 3, 2002 Blacksburg, Virginia Keywords: Proton Exchange Membranes, Direct Copolymerization, Sulfonated Poly (arylene ether sulfone) Random Copolymers, Bisphenol Structure, Sulfonic Acid Sites, Poly (arylene ether sulfones), Fuel Cells Copyright 2002, William L. Harrison SYNTHESIS AND CHARACTERIZATION OF SULFONATED POLY (ARYLENE ETHER SULFONE) COPOLYMERS via DIRECT COPOLYMERIZATION: CANDIDATES for PROTON EXCHANGE MEMBRANE FUEL CELLS William L. Harrison Committee Chairman: Dr. James E. McGrath Department of Chemistry ABSTRACT A designed series of directly copolymerized homo- and disulfonated copolymers containing controlled degrees of pendant sulfonic acid groups have been synthesized via nucleophilic step polymerization. Novel sulfonated poly (arylene ether sulfone) copolymers using 4,4’-bisphenol A, 4,4’-biphenol, hexafluorinated (6F) bisphenol AF, and hydroquinone, respectively, with dichlorodiphenyl sulfone (DCDPS) and 3,3’- disodiumsulfonyl-4,4’-dichlorodiphenylsulfone (SDCDPS) were investigated. Molar ratios of DCDPS and SDCDPS were systematically varied to produce copolymers of controlled compositions, which contained up to 70 mol% of disulfonic acid moiety. The goal is to identify thermally, hydrolytically, and oxidatively stable high molecular weight, film-forming, ductile ion conducting copolymers, which had properties desirable for proton exchange membranes (PEM) in fuel cells.
    [Show full text]
  • Cornforth and Corey-Suggs Reagents As Efficient Catalysts for Sulfonation of Aromatic and Heteroaromatic Compounds Using Nahso3
    Phosphorus, Sulfur, and Silicon and the Related Elements ISSN: 1042-6507 (Print) 1563-5325 (Online) Journal homepage: https://www.tandfonline.com/loi/gpss20 Cornforth and Corey-Suggs reagents as efficient catalysts for sulfonation of aromatic and heteroaromatic compounds using NaHSO3 under solvent free and microwave conditions Touheeth Fatima, Govardhan Duguta, Venkanna Purugula, Hemanth Sriram Yelike & Chinna Rajanna Kamatala To cite this article: Touheeth Fatima, Govardhan Duguta, Venkanna Purugula, Hemanth Sriram Yelike & Chinna Rajanna Kamatala (2020): Cornforth and Corey-Suggs reagents as efficient catalysts for sulfonation of aromatic and heteroaromatic compounds using NaHSO3 under solvent free and microwave conditions, Phosphorus, Sulfur, and Silicon and the Related Elements, DOI: 10.1080/10426507.2020.1782909 To link to this article: https://doi.org/10.1080/10426507.2020.1782909 View supplementary material Published online: 22 Jul 2020. Submit your article to this journal Article views: 9 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=gpss20 PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS https://doi.org/10.1080/10426507.2020.1782909 Cornforth and Corey-Suggs reagents as efficient catalysts for sulfonation of aromatic and heteroaromatic compounds using NaHSO3 under solvent free and microwave conditions Touheeth Fatima, Govardhan Duguta, Venkanna Purugula, Hemanth Sriram Yelike, and Chinna Rajanna Kamatala Department of Chemistry, Osmania University, Hyderabad, Telangana, India ABSTRACT ARTICLE HISTORY Cornforth and Corey-Suggs reagents Pyridinium Dichromate (PDC) and Pyridinium Chlorochromate Received 19 October 2019 (PCC) were explored as efficient catalysts for sulfonation of aromatic and heteroaromatic com- Accepted 10 June 2020 pounds using NaHSO in aqueous acetonitrile medium at room temperature within 1–4 h, while 3 KEYWORDS microwave assisted reactions took place within 1–4 min under solvent-free conditions.
    [Show full text]
  • Development of Novel Protein Kinase Inhibitors As Potential Therapeutics for Breast Cancer Dissertation
    Development of Novel Protein Kinase Inhibitors as Potential Therapeutics for Breast Cancer Dissertation zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) vorgelegt der Naturwissenschaftlichen Fakultät I (Biowissenschaften) der Martin-Luther-Universität Halle-Wittenberg von Dipl. Pharm. Kazem Ahmed Mahmoud geb. am 06.01.1981 in Sohag, Ägypten Gutachter: 1. PD Dr. Andreas Hilgeroth, Halle (Saale) 2. Prof. Dr. Wolfgang Sippl, Halle (Saale) 3. Prof. Dr. Christoph Ritter, Greifswald Halle (Saale), den 03.07.2013 (Tag der Verteidigung) Selbstständigkeitserklärung Hiermit erkläre ich gemäß § 5 (2) b der Promotionsordnung der Naturwissenschaftlichen Fakultät I – Biowissenschaften der Martin-Luther-Universität Halle-Wittenberg, dass ich die vorliegende Arbeit selbstständig und ohne Benutzung anderer als der angegebenen Hilfsmittel und Quellen angefertigt habe. Alle Stellen, die wörtlich oder sinngemäß aus Veröffentlichungen entnommen sind, habe ich als solche kenntlich gemacht. Ich erkläre ferner, dass diese Arbeit in gleicher oder ähnlicher Form bisher keiner anderen Prüfbehörde zur Erlangung des Doktorgrades vorgelegt wurde. Halle, April 2013 __________________________________ Kazem Ahmed Mahmoud Acknowledgment The present work was carried out at the Department of Pharmaceutical Chemistry and Clinical Pharmacy, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany, in the period from April 2010 to October 2012 under the supervision of PD Dr. Andreas Hilgeroth (the leader of Drug Development and Analysis research group). First and foremost, I would like to express my deep thanks and gratitude to my supervisor PD Dr. Andreas Hilgeroth, who allowed me to perform this research in his group, as well as the hiring of the interesting topic, his guidance during this work and the scope for creativity.
    [Show full text]
  • Electrophilic Aromatic Substitution Sandhya Kille Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India
    try: Cu is rre OPEN ACCESS Freely available online em n h t R C e c s i e n a a r c g r h O ISSN: 2161-0401 Organic Chemistry: Current Research Commentary Electrophilic Aromatic Substitution Sandhya Kille Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India COMMENTARY than monomeric sulphur trioxide under such conditions because they are more stable. The reaction follows the conventional two-stage SEAr Aromatic rings don't go through the electrophilic addition processes that mechanism in polar (complexing) media. The rate-controlling transition alkenes do. Instead, they form a substitution product by reacting with state, however, entails, the electrophile affinity (E), which measures the electrophiles—and only in the presence of a catalyst. An electrophile (E+) stabilization energy related with the production of arenium ions, is used replaces H+ in these processes. to quantify the reactivity and regioselectivity in EAS reactions that follow the standard mechanistic framework. There are few application examples In textbooks, monographs, and reviews, the classic SEAr mechanism of offered. electrophilic aromatic substitution (EAS) reactions includes the creation of arenium ion intermediates (complexes) in a two-stage process. The An aromatic ring can be replaced by a variety of electrophiles. In a generality of this mechanistic paradigm is called into question by our halogenation reaction, a halogen atom, commonly chlorine or bromine, findings from multiple studies of EAS reactions. The focus of this report is added to the ring. Nitration and sulfonation reactions are aided by the is on new computational and experimental results for three types of nitro group (NO2) and the sulfonic acid group (SO3H).
    [Show full text]
  • Sulfonic Acid Catalysts Based on Porous Carbons and Polymers Tian Xiao Ning
    SULFONIC ACID CATALYSTS BASED ON POROUS CARBONS AND POLYMERS TIAN XIAO NING NATIONAL UNIVERSITY OF SINGAPORE 2009 SULFONIC ACID CATALYSTS BASED ON POROUS CARBONS AND POLYMERS TIAN XIAO NING (M.Eng) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING NATIONAL UNIVERSITY OF SINGAPORE 2009 Acknowledgement Acknowledgement I would like to convey my deepest appreciation to my supervisor, Assoc. Prof. Zhao X. S., George for his constant encouragement, invaluable guidance, patience and understanding throughout the whole period of my PhD candidature. This project had been a tough but enriching experience for me in research. I would like to express my heartfelt thanks to Assoc. Prof. Zhao for his guidance on writing scientific papers including this PhD thesis. In addition, I want to express my sincerest appreciation to the Department of Chemical and Biomolecular Engineering for offering me the chance to study at NUS with a scholarship. It’s my pleasure to work with a group of brilliant, warmhearted and lovely people, Dr. Su Fabing, Dr. Lv Lu, Dr. Zhou Jinkai, Dr. Li Gang, Dr. Wang Likui, Dr. Bai Peng, Ms. Lee Fang Yin, Ms. Liu Jiajia, Ms. Zhang Li Li, Ms. Wu Pingping, Mr. Cai Zhongyu, Mr. Dou Haiqing, and Mr. Zhang Jingtao. Particular acknowledgement goes to Mr. Chia Phai Ann, Mr. Shang Zhenhua, Dr. Yuan Zeliang, Mr. Mao Ning, Dr. Rajarathnam D., Madam Chow Pek Jaslyn, Mdm Fam Hwee Koong Samantha, Ms Lee Chai Keng, Ms Tay Choon Yen, Mr. Toh Keng Chee, Mr. Chun See Chong, Ms. Ng Ai Mei, Ms.
    [Show full text]
  • POLYPHENYLENE SULFONIC ACIDS AS PROTON EXCHANGE MEMBRANES for FUEL CELLS by DAXUAN DONG Submitted in Partial Fulfillment Of
    POLYPHENYLENE SULFONIC ACIDS AS PROTON EXCHANGE MEMBRANES FOR FUEL CELLS by DAXUAN DONG Submitted in partial fulfillment of the requirements For the degree of Doctor of Philosophy Dissertation advisor: Dr. Morton H. Litt Department of Chemistry CASE WESTERN RESERVE UNIVERSITY May, 2012 CASE WESTERN RESERVE UNIVERSITY SCHOOL OF GRADUATE STUDIES We hereby approve the thesis/dissertation of Daxuan Dong ______________________________________________________ Ph.D. candidate for the ________________________________degree *. Daniel A. Scherson (signed)_______________________________________________ (chair of the committee) Stuart J. Rowan ________________________________________________ Morton H. Litt ________________________________________________ Anthony J. Pearson ________________________________________________ Clemens Burda ________________________________________________ ________________________________________________ 01/20/2012 (date) _______________________ *We also certify that written approval has been obtained for any proprietary material contained therein. Table of Contents Chapter 1. General Introduction………………………………………………………..1 1.1. Fuel cell fundamentals………………………………………………………………..1 1.2. Nafion® and other perfluorosulfonated polymers…………………………………….5 1.3. Sulfonated aromatic hydrocarbon polymers…………………………………….......12 1.3.1. Postsulfonation of existing aromatic hydrocarbon polymers.…………………...12 1.3.2. Direct polymerization from sulfonated aromatic hydrocarbon monomer unit….17 1.3.2.1. Polyarylene ether sulfone copolymers…………………………………………..17
    [Show full text]