International Journal of Molecular Sciences Article Male-Specific Long Noncoding RNA TTTY15 Inhibits Non-Small Cell Lung Cancer Proliferation and Metastasis via TBX4 I-Lu Lai 1, Ya-Sian Chang 1,2, Wen-Ling Chan 1,3, Ya-Ting Lee 1, Ju-Chen Yen 1, Chin-An Yang 4,5,6, Shih-Ya Hung 7 and Jan-Gowth Chang 1,2,3,5,* 1 Epigenome Research Center, China Medical University Hospital, Taichung 404, Taiwan 2 Department of Laboratory Medicine, China Medical University Hospital, Taichung 404, Taiwan 3 Department of Bioinformatics and Medical Engineering, Asia University, Taichung 413, Taiwan 4 Division of General Pediatrics, Children’s Hospital of China Medical University, Taichung 404, Taiwan 5 College of Medicine, China Medical University, Taichung 404, Taiwan 6 Division of Laboratory Medicine, China Medical University Hsinchu Hospital, Hsinchu 302, Taiwan 7 Graduate Institute of Acupuncture Science, China Medical University, Taichung 404, Taiwan * Correspondence:
[email protected]; Tel.: +886-4-22052121 (ext. 2008); Fax: +886-4-22031029 Received: 19 June 2019; Accepted: 13 July 2019; Published: 15 July 2019 Abstract: Gender affects cancer susceptibility. Currently, there are only a few studies on Y chromosome-linked long noncoding RNAs (lncRNAs), and the potential association between lncRNAs and cancers in males has not been fully elucidated. Here, we examined the expression of testis-specific transcript Y-linked 15 (TTTY15) in 37 males with non-small cell lung cancer (NSCLC), and performed circular chromosome conformation capture with next-generation sequencing to determine the genomic interaction regions of the TTTY15 gene. Our results showed that the expression levels of TTTY15 were lower in NSCLC tissues.