Neo-Kraepelinian Divergences from Kraepelin : What Are They and Why They Matter
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FROM MELANCHOLIA to DEPRESSION a HISTORY of DIAGNOSIS and TREATMENT Thomas A
1 FROM MELANCHOLIA TO DEPRESSION A HISTORY OF DIAGNOSIS AND TREATMENT Thomas A. Ban International Network for the History of Neuropsychopharmacology 2014 2 From Melancholia to Depression A History of Diagnosis and Treatment1 TABLE OF CONTENTS Introduction 2 Diagnosis and classifications of melancholia and depression 7 From Galen to Robert Burton 7 From Boissier de Sauvages to Karl Kahlbaum 8 From Emil Kraepelin to Karl Leonhard 12 From Adolf Meyer to the DSM-IV 17 Treatment of melancholia and depression 20 From opium to chlorpromazine 21 Monoamine Oxidase Inhibitors 22 Monoamine Re-uptake Inhibitors 24 Antidepressants in clinical use 26 Clinical psychopharmacology of antidepressants 30 Composite Diagnostic Evaluation of Depressive Disorders 32 The CODE System 32 CODE –DD 33 Genetics, neuropsychopharmacology and CODE-DD 36 Conclusions 37 References 37 INTRODUCTION Descriptions of what we now call melancholia or depression can be found in many ancient documents including The Old Testament, The Book of Job, and Homer's Iliad, but there is virtually 1 The text of this E-Book was prepared in 2002 for a presentation in Mexico City. The manuscript was not updated. 3 no reliable information on the frequency of “melancholia” until the mid-20th century (Kaplan and Saddock 1988). Between 1938 and 1955 several reports indicated that the prevalence of depression in the general population was below 1%. Comparing these figures, as shown in table 1, with figures in the 1960s and ‘70s reveals that even the lowest figures in the psychopharmacological era (from the 1960s) are 7 to 10 times greater than the highest figures before the introduction of antidepressant drugs (Silverman 1968). -
The Kraepelinian Dichotomy – Going, Going . . . but Still Not Gone Nick Craddock and Michael J
The British Journal of Psychiatry (2010) 196, 92–95. doi: 10.1192/bjp.bp.109.073429 Reappraisal The Kraepelinian dichotomy – going, going . but still not gone Nick Craddock and Michael J. Owen Summary Recent genetic studies reinforce the view that current psychiatry will need to move from using traditional approaches to the diagnosis and classification of major descriptive diagnoses to clinical entities (categories and/or psychiatric illness are inadequate. These findings challenge dimensions) that relate more closely to the underlying the distinction between schizophrenia and bipolar disorder, workings of the brain. and suggest that more attention should be given to the relationship between the functional psychoses and neurodevelopmental disorders such as autism. We are Declaration of interest entering a transitional period of several years during which None. The Kraepelinian dichotomy – the broad division of major mood risk gene for schizophrenia,4 and CACNA1C,5 which was strongly and psychotic illness of adulthood into schizophrenia and ‘manic– implicated initially in GWAS of bipolar disorder.6 It is of interest depressive’ (bipolar) illness – has been enshrined in Western that there is evidence that variation at CACNA1C also influences psychiatry for over a century and continues to influence clinical risk of recurrent unipolar depression.5 More broadly, there is practice, research and public perceptions of mental illness. Nearly evidence for overlap in the identity of genes showing gene-wide 5 years ago, we published an editorial1 in which we summarised association signals in GWAS of schizophrenia and bipolar emerging evidence undermining the dichotomy, and argued that disorder.7 Perhaps most compellingly, there is strong evidence that continued adherence to this approach is hampering research and the aggregate polygenic contribution of many alleles of small effect clinical care. -
Bipolar Disorder - Accessscience from Mcgraw-Hill Education
Bipolar disorder - AccessScience from McGraw-Hill Education http://accessscience.com/content/900194 (http://accessscience.com/) Article by: Grunze, Heinz School of Neurology, Neurobiology, and Psychiatry, Newcastle University, Newcastle, United Kingdom. Publication year: 2016 DOI: http://dx.doi.org/10.1036/1097-8542.900194 (http://dx.doi.org/10.1036/1097-8542.900194) Content Course of bipolar disorder What is the neurobiology behind bipolar Bibliography How frequent is bipolar disorder? disorder? Additional Readings Treatment of bipolar disorder A major mental disorder in which there are life-long episodes of both mania and depression; also known as manic-depressive illness. The first recognizable descriptions of mania and depression date back to the writings of Aretaeus of Cappadocia (a Greek physician who lived around 150–200 CE). The modern history of bipolar disorder begins in the mid-nineteenth century with the concept of folie circulaire (“circular insanity”), proposed by the French psychiatrist Jean-Pierre Falret. Later, around the beginning of the twentieth century, it was defined by the work of the German psychiatrist Emil Kraepelin. See also: Affective disorders (/content/affective-disorders/013750) Bipolar disorder is characterized by sudden and often unexplained mood swings, ranging from delirious mania to severe depression. These mood changes are regularly accompanied by other mental and behavioral symptoms, such as fluctuations of volition, activity level, and cognitive functioning. Symptomatic criteria for bipolar disorder have been conceptualized in diagnostic manuals [the two most important being the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) by the American Psychiatric Association and the International Classification of Diseases (ICD-10) by the World Health Organization], with only minor differences between these manuals. -
Bipolar Disorders 100 Years After Manic-Depressive Insanity
Bipolar Disorders 100 years after manic-depressive insanity Edited by Andreas Marneros Martin-Luther-University Halle-Wittenberg, Halle, Germany and Jules Angst University Zürich, Zürich, Switzerland KLUWER ACADEMIC PUBLISHERS NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW eBook ISBN: 0-306-47521-9 Print ISBN: 0-7923-6588-7 ©2002 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow Print ©2000 Kluwer Academic Publishers Dordrecht All rights reserved No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: http://kluweronline.com and Kluwer's eBookstore at: http://ebooks.kluweronline.com Contents List of contributors ix Acknowledgements xiii Preface xv 1 Bipolar disorders: roots and evolution Andreas Marneros and Jules Angst 1 2 The soft bipolar spectrum: footnotes to Kraepelin on the interface of hypomania, temperament and depression Hagop S. Akiskal and Olavo Pinto 37 3 The mixed bipolar disorders Susan L. McElroy, Marlene P. Freeman and Hagop S. Akiskal 63 4 Rapid-cycling bipolar disorder Joseph R. Calabrese, Daniel J. Rapport, Robert L. Findling, Melvin D. Shelton and Susan E. Kimmel 89 5 Bipolar schizoaffective disorders Andreas Marneros, Arno Deister and Anke Rohde 111 6 Bipolar disorders during pregnancy, post partum and in menopause Anke Rohde and Andreas Marneros 127 7 Adolescent-onset bipolar illness Stan Kutcher 139 8 Bipolar disorder in old age Kenneth I. Shulman and Nathan Herrmann 153 9 Temperament and personality types in bipolar patients: a historical review Jules Angst 175 viii Contents 10 Interactional styles in bipolar disorder Christoph Mundt, Klaus T. -
A4-Depression Disease Fact Sheet
Depression Fact Sheet What is Depression? Major depressive disorder (simply known as clinical depression or just depression) is a mental disorder that causes a persistent feeling of sadness and loss of interest¹. Depression is characterized by extended peCommonriods of low mo osymptd. It can lomsead to ainclude: variety of emotional and physical problems and can negatively affect a person's personal life as well as sleeping, eating habits, and general health decrease a person’s ability to function at work and at home. Key facts Depression is a common illness worldwide, with more than 264 million people affected². Major depression is one of the most common mental disorders with a 1-year prevalence of 7.1% with 2/3 having severe functional impairment but with only 1/3 seeking help³. Major depression reduces life expectancy by about 10 years. History The term depression derives from the Latin verb deprimere ("to press down"). The Greek physician Hippocrates årat described a syndrome of melancholia (“black bile”) characterized by all "fears and despondencies, if they last a long time"⁴. Depression became a synonym of melancholia by the end of the 19th century, probably thanks to the German psychiatrist Emil Kraepelin who was the årst to use it as a global term. The denomination “Major depressive disorder” was introduced the mid-1970s and was incorporated into the Diagnostic and Statistical Manual of Mental Disorders (DSM)-III in 1980. Symptoms Not everyone who is depressed experiences every symptom of depression. In many cases, depression symptoms are severe enough to cause problems in daily activities, such as work, school, social activities or relationships. -
Melancholia and Mania: the Historical Contributions of Aretaeus of Cappadocia and Emil Kraepelin
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2020-04-27 Melancholia and Mania: The Historical Contributions of Aretaeus of Cappadocia and Emil Kraepelin Marlier, Krystal Marlier, K. (2020). Melancholia and Mania: The Historical Contributions of Aretaeus of Cappadocia and Emil Kraepelin ( Unpublished master's thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/111923 master thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Melancholia and Mania: The Historical Contributions of Aretaeus of Cappadocia and Emil Kraepelin by Krystal Marlier A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF ARTS GRADUATE PROGRAM IN GREEK AND ROMAN STUDIES CALGARY, ALBERTA APRIL, 2020 © Krystal Marlier 2020 Abstract Two millennia ago, Aretaeus of Cappadocia, a physician from the first to second century CE, first presented a modern portrayal of the relationship between μανίη (mania) and μελαγχολίη (melancholia). His understanding is reflective of the nineteenth-century German clinician, Emil Kraepelin. I propose that Kraepelin and Aretaeus possess more similarities than differences. They were homologous in research techniques and nosology, with one significant difference in aetiology. Presently, Aretaeus’ classification remains recognized in psychiatry, though with a slight deviation in understanding and under different psychiatric labels. -
Affective Disorders
Psychiatr. Pol. 2020; 54(4): 641–659 PL ISSN 0033-2674 (PRINT), ISSN 2391-5854 (ONLINE) www.psychiatriapolska.pl DOI: https://doi.org/10.12740/PP/123167 A half-century of participant observation in psychiatry. Part II: Affective disorders Janusz Rybakowski Poznan University of Medical Sciences, Department of Adult Psychiatry and Department of Psychiatric Nursing Summary The last half-century, thanks to the efforts of outstanding researchers, brought about great progress in the pathogenesis and clinics of affective illnesses. The catecholamine and serotonin hypothesis delineated in the 1960s have retained significant merit. Since the 1990s, the theories have pointed on excessive immune activation and impairment of neuroplasticity under stress. Since the 1970s, a systematic subclassification of unipolar and bipolar affective disorder has proceeded. Epidemiological studies of the last half-century indicated a significantly higher prevalence of depression compared with previous decades. The 21st century brought evidence for a greater frequency of various forms of bipolar affective disorder. During the last 50 years, the etiopathogenesis, diagnosis and treatment of affective disorders were my favorite and fascinating clinical and research topics. This initiated in 1970 when I began my work in the Department of Psychiatry, Medical Academy in Poznan, on account of the introduction of lithium salts for the treatment of these disorders. In 1976–1977, I received a fellowship of the National Institutes of Health at the University of Pennsylvania in Philadelphia and partici- pated in research that elucidated the mechanism of lithium transport across cell membranes. I carried out the studies on the pathogenesis of affective disorders for more than 40 years afterward. -
Treatment of Bipolar Disorder with Antipsychotic Medication: Issues Shared with Schizophrenia
Allan H. Young Treatment of Bipolar Disorder With Antipsychotic Medication: Issues Shared With Schizophrenia Allan H. Young, M.B., Ch.B., M.Phil., Ph.D., F.R.C.Psych., F.R.C.P.(C) Atypical antipsychotics are increasingly used in bipolar disorder as antimanic, antidepressant, and maintenance treatments. Many of the clinical issues related to switching antipsychotics are similar between schizophrenia and bipolar disorder. These include similar motivations for switching due to limited efficacy and unacceptable adverse effects. Particular attention must be paid to the phase of treatment and coprescribed medications. (J Clin Psychiatry 2007;68[suppl 6]:24–25) True Apothecary Kraepelin sought to disentangle these 2 scourges on the Two diagnoses, both alike in dignity, basis of careful clinical description and observation of In fair Psychiatry, where we lay our scene, From ancient balms break to new treatments, natural history. Nevertheless, more than a century later, For psychoses truly patients’ lives demean. this diagnostic scheme is essentially still provisional. Re- cent research has reminded us of the shared etiopathogen- From forth the crises of these two foes esis of bipolar disorder and schizophrenia and has led to Many star-cross’d souls may take their life; 2 The adventured physician overthrows calls for an end to the “Kraepelinian dichotomy.” Al- Do with their wisdom bury their patients’ strife. though such calls may be premature, they do highlight The fearful passage of their delusions—mark’d above, how, on many levels, bipolar disorders and schizophrenia And the continuance of their parents’ sorrow, are inextricably linked. Which, but their children’s health, nought could remove, Is now the few pages’ traffic of our stage; ANTIPSYCHOTIC USE IN BIPOLAR DISORDER The which if you with patient eyes attend, What here shall miss, our toil shall strive to mend. -
Bipolar Ii Disorder and Borderline Personality
Psychiatria Danubina, 2012; Vol. 24, Suppl. 1, pp 197–201 Conference paper © Medicinska naklada - Zagreb, Croatia BIPOLAR II DISORDER AND BORDERLINE PERSONALITY DISORDER - CO-MORBIDITY OR SPECTRUM? Mark Agius1,2,3, Jean Lee2 , Jenny Gardner3,4 & David Wotherspoon 1Department of Psychiatry University of Cambridge, Cambridge, UK 2Clare College Cambridge, Cambridge, UK 3South Essex Partnership University Foundation Trust, UK 4Eastern Deanery, UK. SUMMARY We assess the number of patients who we have on the Database of a Community Mental Health Team in the UK who have Bipolar Disorder and Borderline Personality Disorder. We report how many of these have been seen as having both disorders. Hence we discuss the issue as to whether Borderline Personality disorder is to be placed within the bipolar spectrum. We note the difficulties regarding the use of phenomenology alone to decide this problem, and we note the similarities in genetics, neuroimaging observations and neurobiological mechanisms among the following conditions; Bipolar Disorder, Unipolar Depression, Post- traumatic Stress Disorder, and Borderline Personality Disorder. Ethiologies such as Trauma, Abuse, Childhood adversity and exposure to War appear to influence all these conditions via epigenetic mechanisms. Hence we argue that for a spectrum to be proposed, conditions in the spectrum need to be underpinned by similar or common Neuroimaging and neurobiological mechanisms.On this basis, it may be reasonable to include Borderline Personality Disorder within a broadly described bipolar -
The Kraepelinian Dichotomy in Terms of Suicidal Behaviour
Psychiatria Danubina, 2012; Vol. 24, Suppl. 1, pp 117–118 Conference paper © Medicinska naklada - Zagreb, Croatia THE KRAEPELINIAN DICHOTOMY IN TERMS OF SUICIDAL BEHAVIOUR Jamie King2,4, Mark Agius1,3,5 & Rashid Zaman1,5 1Department of Psychiatry University of Cambridge, Cambridge, UK 2School of Clinical Medicine University of Cambridge, Cambridge, UK 3Clare College Cambridge, Cambridge, UK 4Pembroke College Cambridge, Cambridge, UK 5South Essex Partnership University Foundation Trust, UK SUMMARY The Kraepelinian dichotomy sees schizophrenia and bipolar disorder as two distinctly separate diseases each with its own pathogenesis and disease process. This study looks at the difference between patients with schizophrenia and bipolar disorder in terms of suicidal behaviour. Both schizophrenia and bipolar disorder have been identified as significant risk factors for suicide, while bipolar and major depressive disorder appear to be the greatest diagnostic indicators. This study also aims to look at any differences in suicidal behaviour between the two major classes of bipolar disorder (bipolar I and bipolar II) to possibly determine how distinct these two conditions are in this respect. As expected, this study found that patients with a diagnosis of bipolar disorder were significantly more likely (OR=4.79) to have a history of suicidal behaviour than patients with a diagnosis of schizophrenia. Neither bipolar I nor bipolar II patients were significantly more likely to have a history of suicidal behaviour. However, this study yielded a weak association between bipolar II patients and suicidal behaviour (OR=1.83) compared to bipolar I patients, which may have been more significant under different circumstances such as a greater sample size. -
The Process People with Schizophrenia Or Schizoaffective Disorder Use to Return to Or
The Process People with Schizophrenia or Schizoaffective Disorder Use to Return to or Initially Secure Employment after Diagnosis A dissertation presented to the faculty of the College of Education of Ohio University In partial fulfillment of the requirements for the degree Doctor of Philosophy Willard A. Sheets June 2009 © Willard A. Sheets. All Rights Reserved. 2 This dissertation titled The Process People with Schizophrenia or Schizoaffective Disorder Use to Return to or Initially Secure Employment after Diagnosis by WILLARD A. SHEETS has been approved for the Department of Counseling and Higher Education and the College of Education by Tracy C. Leinbaugh Associate Professor of Counseling and Higher Education Renée A. Middleton Dean, College of Education 3 ABSTRACT SHEETS, WILLARD A., Ph.D., June 2009, Counselor Education The Process People with Schizophrenia or Schizoaffective Disorder Use to Return to or Initially Secure Employment after Diagnosis (184 pp.) Director of Dissertation: Tracy C. Leinbaugh Research indicates that people with schizophrenia or schizoaffective disorder have a high rate of unemployment. This qualitative phenomenological study was designed to explore the perceptions of eight individuals with either disorder who have secured employment after diagnosis. The rationale for this study arises from the researcher’s desire to find the process which was used by individuals with either disorder to become employed. It was the researcher’s assumption that uncovering such a process could lead to implementation of employment as a therapeutic goal of treatment with such individuals. The purposefully selected sample consisted of eight individuals from a Midwestern state who have been diagnosed with either disorder. -
History of Psychiatry
History of Psychiatry Psychobiology Research Group Prof Nicol Ferrier BSc (Hons), MD, FRCP(Ed), FRCPsych Emeritus Professor of Psychiatry Newcastle University History of Psychiatry:- Plan 1. Introduction 2. The concept of affective disorders: historical evolution 3. Current controversies:- a. Classification b. The bipolar/schizophrenia dichotomy c. Mixed states 4. The history of UK asylums 5. The history of ECT and psychopharmacology 6. Antipsychiatry developments 7. Conclusions The first page of Reil’s 1808 article, showing the first use of the word ‘psychiatry’. Andreas Marneros BJP 2008;193:1-3 ©2008 by The Royal College of Psychiatrists Johann Christian Reil, 1759-1813 Professor of medicine at the University of Halle, Germany,1787-1810 According to Reil, the causes of human diseases cannot be distinguished into purely mental, chemical or physical ones, but rather there is an essential interaction among these three domains. ‘Therefore we will never find pure mental, pure chemical or mechanical diseases. In all of them one can see the whole: an affection of the one process of life, which sometimes accentuates this and sometimes that side.’ Reil’s key points about psychiatry Marneros, A BJPsych 2008;193:1-3 Psychiatry (a) Psychiatry is a pure medical specialty. Philosophers and psychologists shall not be allowed to press for ‘incorporation’. (b) Only the best physicians shall become psychiatrists. (c) A medical psychology specific to the needs of the physician shall be fundamental to medical training. (d) Psychiatry, psychosomatics and medical psychology are closely allied. Reil’s key points about psychiatry Marneros, A BJPsych 2008;193:1-3 Mental illness (a) Mental diseases are universal.