Chemistry, Technology, Pharmacology, Medicine’’

The main conference: ‘‘Renewable Wood and Plant Resources: Chemistry, Technology, Pharmacology, Medicine’’ Satellite conferences: Youth school-conference: ‘‘Physical-Chemical Analysis of Organic Compounds of Plant Origin’’ Thematic Symposium of Nonprofit Partnership ‘‘OrCheMed’’ (Organic Chemistry and Medicine) ‘‘Novel Drugs Based on Plant Substances’’ 1 2 3 CONTENTS Renewable Wood and Plant Resources: Chemistry, Technology, Pharmacology, Medicine..............5 Physical-Chemical Analysis of Organic Compounds of Plant Origin.............................................263 Novel Drugs Based on Plant Substances .........................................................................................277 Russian-Austrian Seminar on Cellulose Chemistry.........................................................................298 INDEX .............................................................................................................................................308 4 RENEWABLE WOOD AND PLANT RESOURCES: CHEMISTRY, TECHNOLOGY, PHARMACOLOGY, MEDICINE CONTENTS OF PIGMENTS AND ALKALOIDS IN THE INTRODUCED PLANT CROTALARIA ALATA Z.Ch. Abraeva1, V.I. Akhmedjanova1, N.K. Rakhimova2, A.K. Safarov2 1 - S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences, Republic of Uzbekistan, Tashkent 2 - Scientific-Industrial Center “Botany”, Academy of Sciences, Republic of Uzbekistan [email protected] Crotalaria alata L. (Fabaceae) is one year herbaceous plant known by its honey-bearing and fodder properties. The plant, growing in Australia and countries of America, was introduced to the Botanical garden, Academy of Sciences, Uzbekistan. We studied for the first time the contents of pigments in leaves and alkaloids in different organs of C. alata collected at the Botanical garden in the phase of flowering-fruiting. An each air-dried organ of the plant was extracted separately with ethanol. Isolation of pigments from leaves and total alkaloids from beans, leaves, seeds, flowers, roots, and stems was carried out by known methods. The content of green pigments (chlorophylls) in leaves was 8.32 mg/g damp weight and yellow pigments (carotenoids), 2.04 mg/g, i.e., more than 4 times less. Chlorophyll “a” predominated among chlorophylls (a+b). The highest content of alkaloids was found in beans (0.49% of dry weight of raw material) and leaves (0.48%). Seeds contained alkaloids (0.24%) about 2 times less than beans and leaves; flowers, 0.19%. Significant decrease of an alkaloid amount was observed in roots (0.04%) and stems (0.03%). Thus, Crotalaria alata, introduced to Uzbekistan, has been found to contain alkaloids, which in the phase of flowering-fruiting accumulate mainly in beans and leaves. MULTIASPECT CHEMICAL AND PHARMACOLOGICAL RESEARCHES OF RAW MATERIAL OF KAZAKHSTAN S.M. Adekenov International research and production holding Phytochemistry [email protected] The unique and rich flora of Republic of Kazakhstan is a renewed source of biologically active compounds for development of the new original preparations with wide spectrum of action. More 6000 species of plants are numbered, from which 667 species are endemic. The various chemical compositions of plants develop the certain difficulties at isolation of individual compounds and demand the adaptation of technological processes for the obtaining of the biologically active substances. Thus, the complex processing of raw material as a renewed material with application of ecologic safe methods and innovation technologies is one of the priority approaches at the multiaspect chemical study of plants by way of the obtaining of compounds with the practically valuable properties. Thus, the endemic plan of Kazakhstan of Artemisia glabella Kar. et Kir. is a source of the biologically active compounds such as, arglabin, argolid, bonansin, pectolinarigenin, cyrsilineole, casticin, luteolin, 1,8-cineole, linalool, terpineol-4, -terpineol, sabinol, umbelliferone, glutamine, triptophan, arginin, tirosin, prolin, leicin, glutamic acid, glucose, dulcit, rhamnose, gallic, protocathechuic, caffeic and salicylic acids. 5 Other species of Artemisia leucodes Schrenk. is a perspective source of compounds such as, camphor, camphene, 1,8-cineole, chrysanthenylacetate, chrysanthenon, nerylacetate, austricin, leucomisin, parishin C, anhydroaustricin, matricarin, artelin, 5(Н)-austricin. The investigations on the isolation of sesquiterpene lactones are carried out by the supercritical fluid extraction method from Artemisia glabella Kar. et Kir. and Artemisia leucodes Schrenk. at the International research and production holding “Phytochemistry”. It is determined that CO2 - extraction provides the exhaustive extraction of the sum of the biologically active substances of the hydrophobic nature, with full absence of solvent in the finished product. It permits to keep the native structure of molecule and biological activity. The effective, economic, ecologically safe methods of the isolation and purification of the individual sesquiterpene lactones of arglabin and leucomisin with application of the centrifugal partition chromatography in combination with the preparative high-performance liquid chromatography are introduced for the first time. It shows the high efficiency, comparative automation and significant reduction of process duration, toxic solvents’ removal and the conformance to requirements GMP. The unique domestic antitumor preparation “Arglabin” (RК-MD-5-№000726; RF-MD-№001578) are developed on the basis of sesquiterpene lactone arglabin. The essential oil, obtained from СО2- extract of Artemisia glabella Kar. et Kir. after extraction of arglabin, possesses the high antimicrobial and antitubercular activity. As a result the new phytopreparation “Epherol” (RK-MD- 3-№004787) is developed on its basis. After the CO2-extraction the wastes of raw material of Artemisia glabella Kar. et Kir. are presented the natural biopolymer, which is a valuable source for the obtaining of others biologically active materials, for example, the phenolic compounds (bonansin, pectolinarigenin, cyrsilineole, casticin, luteolin and others). This has permitted to offer the regulation of the complex waste-free method of the obtaining of the essential oil, arglabin and phenolic compounds from raw material of Artemisia glabella Kar. et Kir. The hypolipidemic drug “Aterolid” (RK-MD-3-№000711) is developed on the basis of leucomisin, isolated from CO2-extract of Artemisia leucodes Schrenk. In addition, the CO2-extraction of Artemisia leucodes Schrenk. permits to isolate quantitatively leucomisin and others pharmacologically active compounds such as, camphor and sesquiterpene lactones from raw material. They are renewed material for the obtaining of new compounds with the expressed biological activity. As a result of the multiple-aspect approach at the chemical and pharmacological research of plant objects at holding “Phytochemistry”, more 1700 compounds are isolated and identified from more 500 species of plants: 1500 mono- and sesquiterpenoids essential oils, 120 sesquiterpene lactones, more 50 ecdysteroids, 25 alkaloids and 40 flavonoids. On basis of their molecules about 2000 new compounds with practically valuable properties are synthesized. At holding “Phytochemistry” the developed laboratory and trial regulations of the complex processing of raw material have permitted to organize the production of the original phytopreparations such as, “Arglabin”, “Salsocollin”, “Epherol”, “Darmenin”, “Aterolid”, “Sausalin” and “Ecdyphyt”, totally 43 names at the Karaganda pharmaceutical factory. Thus, the raw material of Republic of Kazakhstan is renewed resource for the obtaining of materials with practically valuable properties, which can be used at the complex processing for development of the new original preparations with wide spectrum action, biologically active additives, perfumery-cosmetic means, etc. 6 USE THE SPECIAL WASTE PAPER FOR PRODUCTION CARBOXYMETHYL CELLULOSE, SODIUM SALT M.A. Ageev, I.A. Blinova, A.Ya. Ageev The Ural state forest engineering university, Ekaterinburg, Russia [email protected] The special waste paper (МБС) – it shabby monetary banknotes doesn't find now rational application. At the same time composite structure МБС on a fibre, represents a great interest to possibility of use for production carboxymethyl cellulose, sodium salt (Na-CMC) instead of traditional raw materials – cotton and viscose cellulose. Characteristic МБС is presented in table 1. Table 1 – Characteristic МБС Polymerization Structure on a fibre α - cellulose, % Ash content, % degree, in limits Cotton, sulfate and sulfite bleached pulp of deciduous 1000 – 1500 90,5 ± 0,2 3,81 ± 0,2 and coniferous woods On the department of chemistry of wood and technology of pulp-and-paper production (ХД и ТЦБП) Urals state forest engineering university (УГЛТУ) the way of production Na-CMC from МБС is developed. For the purpose inturgescence and removal of paint МБС have subjected to hydrothermal processing NaOH solution. A printing ink particles have removed a flotation method. The waste paper weight subjected to powdering in 18 % NaOH solution with the subsequent dehydration to frequency rate 2,65. Powdering МБС mixed with CH2ClCOONa. Reaction end spent without hashing in special devices. The received technical product dried up hot air. The carried out analysis of properties of a product from МСБ in comparison with commodity products is presented in table 2. Table 2 – Indicators of quality technical carboxymethyl cellulose,

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