Single Dopants in Semiconductors Paul M

Total Page:16

File Type:pdf, Size:1020Kb

Single Dopants in Semiconductors Paul M REVIEW ARTICLE PUBLISHED ONLINE: 24 JANUARY 2011!|!DOI: 10.1038/NMAT2940 Single dopants in semiconductors Paul M. Koenraad1 and Michael E. Flatté2 The sensitive dependence of a semiconductor’s electronic, optical and magnetic properties on dopants has provided an extensive range of tunable phenomena to explore and apply to devices. Recently it has become possible to move past the tunable properties of an ensemble of dopants to identify the e!ects of a solitary dopant on commercial device performance as well as locally on the fundamental properties of a semiconductor. New applications that require the discrete character of a single dopant, such as single-spin devices in the area of quantum information or single-dopant transistors, demand a further focus on the properties of a specific dopant. This article describes the huge advances in the past decade towards observing, controllably creating and manipulating single dopants, as well as their application in novel devices which allow opening the new field of solotronics (solitary dopant optoelectronics). arly on in semiconductor research, the ubiquity of unintentional behaviour. About 10 years ago it was realized that single impurities dopants meant that reproducible results were rare; as late as 1931, could be used to physically realize the ‘qubits’ of quantum physicist Wolfgang Pauli opined in a letter1 to Rudolph Peierls computation, with a single phosphorus dopant’s nuclear spin7, or a E 8 9 that “one shouldn’t work on semiconductors, that is a !lthy mess; who single dopant’s bound electron spin or charge . Single dopants are knows whether any semiconductors exist.” Eight decades later, the suggested not only as qubits for quantum computing but also as non- purity of germanium is better than 1 part in 1011, permitting almost classical light sources in quantum information science for quantum nine orders of magnitude variability in doping concentration. Silicon key distribution systems, quantum repeaters, quantum lithography, purity is similar. Yet even with this current exquisite control, the multivalent logic and local sensing. Single impurities have already dopants usually still play a supporting role in current devices, by mod- shown their importance for non-classical light sources through the ifying the chemical potential of a material. At these levels of purity, demonstration of single-photon emission from nitrogen-vacancy each unintentional dopant is on average more than a micrometre (NV) centres in diamond10, isoelectronic tellurium impurity centres away from any other unintentional dopant. "us devices on the nano- in ZnSe (ref. 11) and N pairs in GaP (ref. 12) as well as triggered scale can be expected to have absolutely no unintentional dopants, single-photon emission in the case of N-acceptors in ZnSe (ref. 13) and if the doping is carefully controlled a device can be constructed and NV centres in diamond14. with one and only one dopant — a solitary dopant opto electronic, "e above examples may be viewed as the initial demonstrations or solotronic, device. And, as atoms are the building blocks of mat- and model device designs on the path to a fully $edged solotronic ter, a solotronic device is where the miniaturization of semiconductor technology, which requires considerable additional fundamen- devices reaches the limits set by the discrete nature of matter. tal study and device application. "e desirable features of solitary Although the properties of individual dopants determine some dopants, such as the reproducible quantized properties of a speci!c aspects of a doped device (such the dependence of carrier freeze- dopant, make them ideal objects for further scienti!c study and out on the dopant binding energy), the !rst e#ect of individual robust applications. However, a reliance on the properties of a soli- dopant dynamics on devices was through electronic noise. About tary dopant generates new challenges: device behaviour depends 30 years ago one of the main sources of Lorentz noise in metal– on the local environment (strain, electric, magnetic and optical oxide–semiconductor !eld-e#ect transistor (MOSFET) devices was !elds) and the dopant position within the device. Scienti!c study traced to the trapping and detrapping of charge carriers at impu- of single-atom behaviour is most advanced in single-atom and rity centres close to the conduction channel. Owing to the high single-ion electromagnetic traps in vacuum; study of the solitary purity of the semiconductor materials and the increasingly small dopant in a solid also takes advantage of a natural form of trap- device sizes, discrete impurities started to show up in most device ping, as the solitary impurity is held in place by the electromagnetic transport properties. Random telegraph noise from an individual !elds of the host solid around it, but on a length scale orders of impurity was !rst observed at low temperatures in MOSFETs2 and magnitude smaller. quantum point contact structures3 and later at room temperature Why is our focus on the solitary dopant in a semiconductor, in bipolar transistors4. Such developments imply that individual rather than a metal or insulator? To reduce the electronic interac- impurities might ultimately dominate the device characteristics of tion of the single dopant with the host, and preserve some of the future MOSFET transistors5. "e potential $uctuations from indi- discrete character of the dopant, the host should not be a metal; the vidual impurities in a MOSFET transistor are shown in Fig. 1a. overlap of a host metal’s electronic states and impurity states is too Controlled positioning of these impurities can improve threshold large for a single impurity to dominate the properties. However, a voltage reproducibility for MOSFETs, as shown in Fig. 1b–e (ref. 6). host insulator is also less than optimal, for to enable the applica- "e International Technology Roadmap for Semiconductors (ITRS) tion of external electric !elds and couple the single dopant to trans- speci!cally discusses the need for accurate three-dimensional (3D) port, the host should be a semiconductor. "us the exploration and dopant incorporation, pro!ling and modelling. manipulation of a single dopant in a semiconducting host should "e detection of the discrete properties of solitary dopants in be the focus of solotronic research, and holds promise for device individual devices motivated new device designs that required this applications as diverse as scalable sources for quantized emission, 1COBRA Inter-University Research Institute, Department of Applied Physics, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands. 2Department of Physics and Astronomy, University of Iowa, 203 VAN, Iowa City, Iowa 52242, USA. *e-mail: [email protected]; michael_fl[email protected] NATURE MATERIALS | VOL 10 | FEBRUARY 2011 | www.nature.com/naturematerials 91 © 2011 Macmillan Publishers Limited. All rights reserved nmat_2940_FEB11.indd 91 11/1/11 11:56:33 REVIEW ARTICLE NATURE MATERIALS DOI: 10.1038/NMAT2940 a to obtain detailed information about the responsible impurity itself. One exception is the use of noise in a conduction channel to measure the spin state of a single impurity8. A spin-to-charge transformation can occur when the impurity, by virtue of the Pauli principle, can only bind a second electron with opposite spin. Recently this tactic was applied to monitor the spin resonance of a single paramagnetic 15 impurity at the Si/SiO2 interface . Single impurities also manifested their presence in tunnel- ling. In a double-barrier resonant-tunnelling (DBRT) diode with a micrometre-sized diameter, features in the I–V curves could be related to the presence of a single Si donor in the DBRT well16. Although DBRT structures enabled the determination of the spin- splitting of an individual Si doping atom located in a GaAs quantum bc8 8 well17 as well as located in an AlAs barrier18, and an estimate of the Ave. Vth = –0.4V 19 7 7 extension of the wavefunction of the impurity state , their use is o%en hampered by the uncontrolled incorporation and unknown 6 6 chemical nature of the impurity state. Other tunnelling approaches 5 5 have used a single impurity to scan the density-of-states (DOS) 20 4 4 spectrum of a two-dimensional electron gas or shown the presence 21,22 equency equency Ave. Vth = –0.2V of a single impurity in industrial-type nano-MOSFETs . Fr Fr 3 3 Optical identi!cations of an individual semiconductor impurity 2 2 followed a%er tunnelling identi!cation16, by analysing the electro- 1 1 luminescence of a doped large-area DBRT structure and relating sharp lines to the presence of independent acceptors in the DBRT’s 0 0 23 –2 –1 0 12 –2 –1 0 12 well . "e application of standard high-resolution optical spectros- Vth [V] Vth [V] copy on a GaAs sample with a low density of N-pairs allowed for the !rst luminescence study of individual isoelectronic N-pairs24. d Drain e Drain An improved optical assessment of individual impurities, by opti- cal excitation and detection, could be obtained by confocal micro- scopy in combination with solid immersion lenses that reduce the m spot size to about 250 nm in the visible range of the spectrum. 2 1. "is approach allowed the observation of single NV centres in dia- mond25. A length scale of 250 nm is still large compared with the typical distance between impurities, but new approaches, such as stimulated emission depletion microscopy, show a superior reso- lution, better than 10 nm for an impurity in diamond26. For more Sour ce Sour common optical analysis techniques, the impurities have to be spec- ce 100 nm 300 nm troscopically singled out from the background, and their concentra- tion must be very low. For NV centres in diamond, which can have 9 −3 Figure 1 | Impurities in a MOSFET device. a, Simulation of the potential concentrations of the order of 10 cm or even lower depending on distribution in a 50-nm MOSFET device showing the potential fluctuations the growth conditions, this methodology works very well.
Recommended publications
  • Nanoparticle Arrays on Surfaces for Electronic, Optical, and Sensor Applications** Andrew N
    18 WILEY-VCH-Verlag GmbH, D-69451 Weinheim, 2000 1439-4235/00/01/01 $ 17.50+.50/0 CHEMPHYSCHEM 2000,1,18±52 Nanoparticle Arrays on Surfaces for Electronic, Optical, and Sensor Applications** Andrew N. Shipway,[a] Eugenii Katz,[a] and Itamar Willner*[a] Particles in the nanometer size range are attracting increasing their organization on surfaces for the construction of functional attention with the growth of interest in nanotechnological interfaces. In this review, we address the research that has led to disciplines. Nanoparticles display fascinating electronic and optical numerous sensing, electronic, optoelectronic, and photoelectronic properties as a consequence of their dimensions and they may be interfaces, and also take time to cover the synthesis and easily synthesized from a wide range of materials. The dimensions characterization of nanoparticles and nanoparticle arrays. of these particles makes them ideal candidates for the nano- engineering of surfaces and the fabrication of functional nano- KEYWORDS: structures. In the last five years, much effort has been expended on colloids ´ interfaces ´ monolayers ´ nanostructures ´ sensors 1. Introduction The emerging disciplines of nanoengineering,[1] nanoelectron- optical,[7, 10±13] and catalytic[14] properties originating from their ics,[2] and nanobioelectronics[3] require suitably sized and func- quantum-scale dimensions.[15] tional building blocks with which to construct their architectures In order to tailor the new generation of nanodevices and and devices. This need has encouraged
    [Show full text]
  • CHAPTER 8: Diffusion
    1 Chapter 8 CHAPTER 8: Diffusion Diffusion and ion implantation are the two key processes to introduce a controlled amount of dopants into semiconductors and to alter the conductivity type. Figure 8.1 compares these two techniques and the resulting dopant profiles. In the diffusion process, the dopant atoms are introduced from the gas phase of by using doped-oxide sources. The doping concentration decreases monotonically from the surface, and the in-depth distribution of the dopant is determined mainly by the temperature and diffusion time. Figure 8.1b reveals the ion implantation process, which will be discussed in Chapter 9. Generally speaking, diffusion and ion implantation complement each other. For instance, diffusion is used to form a deep junction, such as an n-tub in a CMOS device, while ion implantation is utilized to form a shallow junction, like a source / drain junction of a MOSFET. Boron is the most common p-type impurity in silicon, whereas arsenic and phosphorus are used extensively as n-type dopants. These three elements are highly soluble in silicon with solubilities exceeding 5 x 1020 atoms / cm3 in the diffusion temperature range (between 800oC and 1200oC). These dopants can be introduced via several means, including solid sources (BN for B, As2O3 for As, and P2O5 for P), liquid sources (BBr3, AsCl3, and POCl3), and gaseous sources (B2H6, AsH3, and PH3). Usually, the gaseous source is transported to the semiconductor surface by an inert gas (e.g. N2) and is then reduced at the surface. 2 Chapter 8 Figure 8.1: Comparison of (a) diffusion and (b) ion implantation for the selective introduction of dopants into a semiconductor substrate.
    [Show full text]
  • Designing a Nanoelectronic Circuit to Control a Millimeter-Scale Walking Robot
    Designing a Nanoelectronic Circuit to Control a Millimeter-scale Walking Robot Alexander J. Gates November 2004 MP 04W0000312 McLean, Virginia Designing a Nanoelectronic Circuit to Control a Millimeter-scale Walking Robot Alexander J. Gates November 2004 MP 04W0000312 MITRE Nanosystems Group e-mail: [email protected] WWW: http://www.mitre.org/tech/nanotech Sponsor MITRE MSR Program Project No. 51MSR89G Dept. W809 Approved for public release; distribution unlimited. Copyright © 2004 by The MITRE Corporation. All rights reserved. Gates, Alexander Abstract A novel nanoelectronic digital logic circuit was designed to control a millimeter-scale walking robot using a nanowire circuit architecture. This nanoelectronic circuit has a number of benefits, including extremely small size and relatively low power consumption. These make it ideal for controlling microelectromechnical systems (MEMS), such as a millirobot. Simulations were performed using a SPICE circuit simulator, and unique device models were constructed in this research to assess the function and integrity of the nanoelectronic circuit’s output. It was determined that the output signals predicted for the nanocircuit by these simulations meet the requirements of the design, although there was a minor signal stability issue. A proposal is made to ameliorate this potential problem. Based on this proposal and the results of the simulations, the nanoelectronic circuit designed in this research could be used to begin to address the broader issue of further miniaturizing circuit-micromachine systems. i Gates, Alexander I. Introduction The purpose of this paper is to describe the novel nanoelectronic digital logic circuit shown in Figure 1, which has been designed by this author to control a millimeter-scale walking robot.
    [Show full text]
  • DNA-Based Artificial Nanostructures: Fabrication, Properties And
    (Invited) Chapter V in “Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology,” Vols. 1-2 (ISBN: 1-58883-033-0), edited by Nalwa, American Scientific Publishers (2005). DNA-based Artificial Nanostructures: Fabrication, Properties, and Applications Young Sun and Ching-Hwa Kiang* Department of Physics & Astronomy, Rice University 6100 Main Street - MS61, Houston, TX 77005, USA Phone: (713) 348-4130, Fax: (713) 348-4150, E-mail: [email protected] Keywords: DNA; nanostructure; self-assembly; nanoparticle; carbon nanotube; biosensor. *To whom correspondence should be addressed: [email protected]. 1 Table of Content 1. Introduction 2. DNA fundamentals 3. Attachment of DNA to surface 4. Fabrication of nanostructures using DNA 4.1 Nanostructures of pure DNA 4.2 DNA-based assembly of metal nanoparticles 4.3 Construction of semiconductor particle arrays using DNA 4.4 DNA-directed nanowires 4.5 DNA-functionalized carbon nanotubes 4.6 Field-transistor based on DNA 4.7 Nanofabrication using artificial DNA 5. DNA-based nanostructures as biosensors 6. Properties of DNA-linked gold nanoparticles 6.1 Aggregation of DNA-modified gold nanoparticles 6.2 Melting of DNA-linked gold nanoparticle aggregations 6.3 Effects of external variables on the melting properties 7. Conclusion 2 1. Introduction The integration of nanotechnology with biology and bioengineering is producing many advances. The essence of nanotechnology is to produce and manipulate well- defined structures on the nanometer scale with high accuracy. Conventional technologies based on the "top-down” approaches, such as the photolithographyic method, are difficult to continue to scale down due to real physical limitations including size of atoms, wavelengths of radiation used for lithography, and interconnect schemes.
    [Show full text]
  • Contactless, Nondestructive Determination of Dopant Profiles Of
    www.nature.com/scientificreports OPEN Contactless, nondestructive determination of dopant profles of localized boron-difused regions in Received: 11 November 2018 Accepted: 9 July 2019 silicon wafers at room temperature Published: xx xx xxxx Hieu T. Nguyen , Zhuofeng Li, Young-Joon Han , Rabin Basnet, Mike Tebyetekerwa , Thien N. Truong , Huiting Wu, Di Yan & Daniel Macdonald We develop a photoluminescence-based technique to determine dopant profles of localized boron- difused regions in silicon wafers and solar cell precursors employing two excitation wavelengths. The technique utilizes a strong dependence of room-temperature photoluminescence spectra on dopant profles of difused layers, courtesy of bandgap narrowing efects in heavily-doped silicon, and diferent penetration depths of the two excitation wavelengths in silicon. It is fast, contactless, and nondestructive. The measurements are performed at room temperature with micron-scale spatial resolution. We apply the technique to reconstruct dopant profles of a large-area (1 cm × 1 cm) boron-difused sample and heavily-doped regions (30 μm in diameter) of passivated-emitter rear localized-difused solar cell precursors. The reconstructed profles are confrmed with the well- established electrochemical capacitance voltage technique. The developed technique could be useful for determining boron dopant profles in small doped features employed in both photovoltaic and microelectronic applications. An attractive approach for improving light-to-electricity power conversion efciencies of crystalline silicon (c-Si) solar cells is to minimize surface areas of heavily-doped layers. Tis is due to the high recombination-active nature of the heavily-doped layers, causing a signifcant loss of photo-induced electrons and holes. Several solar cell designs employing this concept have been proved to achieve efciencies over 24% such as interdigitated back-contact (IBC)1–3 and passivated-emitter rear localized-difused (PERL)4–6 cell structures.
    [Show full text]
  • Metal and Semiconductor Nanoparticle Self-Assembly
    Metal and Semiconductor Nanoparticle Self-Assembly by G. Daniel Lilly A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy (Chemical Engineering) in The University of Michigan 2009 Doctoral Committee: Professor Nicholas A. Kotov, Chair Professor Sharon C. Glotzer Professor Xiaoqing Pan Assistant Professor Suljo Linic © G. Daniel Lilly 2009 To my wife, Michelle M. Lilly, Ph.D. To my mother and father, Nancy N. and G. Bud Lilly ii ACKNOWLEDGEMENTS I would like to thank my loving and lovely wife Michelle for her support through the process of obtaining my Ph.D. If not for her support and advice I most likely would not have finished this process. I value her as a friend and partner and am forever appreciative of her actions. I would also like to thank my parents for laying the groundwork in my life to accomplish this. They taught me the value of hard work and persistence when reaching toward your goals, and without these lessons I most likely would not have even gone to graduate school, much less finished. I am appreciative for all the help and support my fellow lab members have given me over the last five years. Former lab members Jaebeom Lee, Zhiyong Tang, Paul Podsiadlo, Bongsup Ship, Jungwoo Lee and Kevin Critchley helped teach me new lab techniques, NP synthesis and conjugation techniques, and numerous analysis procedures, and allowed me a venue to discuss my hypotheses concerning these approaches. Current lab members Meghan Cuddihy, Edward Jan, Peter Ho, Ashish Agarwal, Christine Andres, Jian Zhu, Huanan Zhang, Elizabeth Stewart, Yichun Wang, Inigo Alvarez, Shimei Xu, and Anna Fernandez aided with various collaborations, techniques, procedures, and experiences for which I am grateful.
    [Show full text]
  • Directed Self-Assembly of Block Copolymers for the Fabrication of Nanomechanical Structures
    ADVERTIMENT. Lʼaccés als continguts dʼaquesta tesi queda condicionat a lʼacceptació de les condicions dʼús establertes per la següent llicència Creative Commons: http://cat.creativecommons.org/?page_id=184 ADVERTENCIA. El acceso a los contenidos de esta tesis queda condicionado a la aceptación de las condiciones de uso establecidas por la siguiente licencia Creative Commons: http://es.creativecommons.org/blog/licencias/ WARNING. The access to the contents of this doctoral thesis it is limited to the acceptance of the use conditions set by the following Creative Commons license: https://creativecommons.org/licenses/?lang=en Directed self-assembly of block copolymers for the fabrication of nanomechanical structures Christian Pinto Gómez Dissertation for the degree of Doctor in Electronic and Telecommunication Engineering Advisor: Marta Fernández Regúlez Academic tutor: Joan Bausells Roigé Department of Electronic Engineering Universitat Autònoma de Barcelona 2021 This is to certify that this thesis has been written by Christian Pinto Gómez and is submitted to obtain the degree of Doctor of Philosophy in Electronic and Telecommunication Engineering under guidance and supervision of Dr. Marta Fernández Regúlez (IMB-CNM, CSIC). Advisor: Marta Fernández Regúlez Christian Pinto Gómez Academic tutor: Joan Bausells Roigé i ii Abstract The main goal of this dissertation, entitled “Directed self-assembly of block copolymers for the fabrication of nanomechanical structures”, is to demonstrate the possibility of fabricating nanomechanical functional structures by employing the directed self- assembly (DSA) of block copolymers (BCPs) as a nanopatterning tool. DSA is a bottom-up nanolithography technique based on the ability of BCPs to segregate into domains at the micro/nanoscale, and it has attracted high interest due to its inherent simplicity, high throughput, low cost and potential for sub-10 nm resolution.
    [Show full text]
  • Gain in Polycrystalline Nd-Doped Alumina: Leveraging Length Scales to Create a New Class of High-Energy, Short Pulse, Tunable Laser Materials Elias H
    Penilla et al. Light: Science & Applications (2018) 7:33 Official journal of the CIOMP 2047-7538 DOI 10.1038/s41377-018-0023-z www.nature.com/lsa ARTICLE Open Access Gain in polycrystalline Nd-doped alumina: leveraging length scales to create a new class of high-energy, short pulse, tunable laser materials Elias H. Penilla1,2,LuisF.Devia-Cruz1, Matthew A. Duarte1,2,CoreyL.Hardin1,YasuhiroKodera1,2 and Javier E. Garay1,2 Abstract Traditionally accepted design paradigms dictate that only optically isotropic (cubic) crystal structures with high equilibrium solubilities of optically active ions are suitable for polycrystalline laser gain media. The restriction of symmetry is due to light scattering caused by randomly oriented anisotropic crystals, whereas the solubility problem arises from the need for sufficient active dopants in the media. These criteria limit material choices and exclude materials that have superior thermo-mechanical properties than state-of-the-art laser materials. Alumina (Al2O3)isan ideal example; it has a higher fracture strength and thermal conductivity than today’s gain materials, which could lead to revolutionary laser performance. However, alumina has uniaxial optical proprieties, and the solubility of rare earths (REs) is two-to-three orders of magnitude lower than the dopant concentrations in typical RE-based gain media. We present new strategies to overcome these obstacles and demonstrate gain in a RE-doped alumina (Nd:Al2O3) for the first time. The key insight relies on tailoring the crystallite size to other important length scales—the wavelength of 1234567890():,; 1234567890():,; 1234567890():,; 1234567890():,; light and interatomic dopant distances, which minimize optical losses and allow successful Nd doping.
    [Show full text]
  • Effects of Dopant Additions on the High Temperature Oxidation Behavior of Nickel-Based Alumina- Forming Alloys
    Effects of Dopant Additions on the High Temperature Oxidation Behavior of Nickel-based Alumina- forming Alloys by Talia L. Barth A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy (Materials Science and Engineering) in the University of Michigan 2020 Doctoral Committee: Professor Emmanuelle Marquis, Chair Assistant Professor John Heron Professor Krishna Garikipati Professor Alan Taub Talia L. Barth [email protected] ORCID iD: 0000-0001-8266-7447 © Talia L. Barth 2020 ACKNOWLEDGEMENTS I would like to first offer my heartfelt thanks to my advisor, Professor Emmanuelle Marquis, without whom this work would not have been possible. Her exceptional mentorship has had an immense impact on my development as a researcher and a person, and her support and guidance along my journey have been invaluable. I would also like to express my appreciation for the rest of my committee, Professor Alan Taub, Assistant Professor John Heron, and Professor Krishna Garikipati for providing valuable advice and support for the completion of this work. I am grateful to the staff at the Michigan Center for Materials Characterization (MC)2, especially to Allen Hunter, Bobby Kerns, Haiping Sun, and Nancy Muyanja whose training enabled me to work confidently on the characterization instruments essential to this dissertation, and were always eager to lend their expertise with data collection and analysis. My colleagues in the Marquis group over the years were also important to this work and to my professional and personal development. I would like to thank Kevin Fisher, Ellen Solomon, Elaina Reese, and Peng-Wei Chu for getting me up to speed in the lab and for being there as mentors and friends in my first years as a grad student.
    [Show full text]
  • Viral Surveillance and Discovery (Current Opinion in Virology)
    Available online at www.sciencedirect.com Viral surveillance and discovery Walter Ian Lipkin and Cadhla Firth The field of virus discovery has burgeoned with the advent of applications given recent improvements in drugs and high throughput sequencing platforms and bioinformatics vaccines. The lack of effective therapies once made programs that enable rapid identification and molecular the diagnosis of viral infection primarily an academic characterization of known and novel agents, investments in exercise; however, the expanding armamentarium of global microbial surveillance that include wildlife and domestic countermeasures for specific viruses promises unprece- animals as well as humans, and recognition that viruses may be dented opportunities to reduce morbidity, mortality and implicated in chronic as well as acute diseases. Here we review the economic costs of viral infections. methods for viral surveillance and discovery, strategies and pitfalls in linking discoveries to disease, and identify Tools for the hunt opportunities for improvements in sequencing instrumentation Tissue culture and analysis, the use of social media and medical informatics Although this classical method for viral discovery is dis- that will further advance clinical medicine and public health. missed by some investigators as cumbersome, expensive Addresses and quaint, we continue to use it for several reasons. First, Center for Infection and Immunity, Mailman School of Public Health of the growth of an agent in culture provides an excellent Columbia University, 722 West 168th Street, New York, NY 10025, USA source of enriched template for molecular characteriz- ation. Additionally, having an inoculum for animal model Corresponding author: Lipkin, Walter Ian ([email protected]) studies, a cell-based assay for serology or a titered stock for neutralization tests greatly aids the pursuit of the proof of disease causation [11–14].
    [Show full text]
  • Nanoscience and Genomics
    NANOSCIENCE AND GENOMICS LIST OF NEW COURSES (2020) Sl. No Course Code Name of the Course Credits 1 20NT3001 Vacuum and Thin Film Technology 3:0:0 2 20NT3002 Semiconductors, Instrumentation and Advanced Design 3:0:0 3 20NT3003 Analytical Methods and Spectroscopy 3:0:0 4 20NT3004 Nanomaterials in Biology and Medicine 3:0:0 5 20NT3005 Synthesis and Functionalization of Nanomaterials 3:0:0 6 20NT3006 Biomolecules in Nanoscience 3:0:0 7 20NT3007 Thin Film Lab 0:0:2 8 20NT3008 Synthesis and Functionalization of Nanomaterials Laboratory 0:0:2 9 20NT3009 Magnetic Nanomaterials 3:0:0 10 20NT3010 Human Physiology 3:0:0 11 20NT3011 Nanoelectronics and Micro-Nanofabrications 3:0:0 12 20NT3012 Microbiology and Immunology 3:0:0 13 20NT3013 Self-assembled and Functional Nanostructures 3:0:0 14 20NT3014 Molecular and Nanoscale Thermodynamics 3:0:0 15 20NT3015 Nanoelectronics Lab 0:0:2 16 20NT3016 Characterization of Nanomaterials Laboratory 0:0:2 17 20NT3017 Luminescent Nanomaterials 3:0:0 18 20NT3018 Commercialization of Nanotechnology Products 3:0:0 19 20NT3019 Cancer Nanomedicine 3:0:0 20 20NT3020 Nanomaterial-Based Energy Devices 3:0:0 21 20NT3021 Nano-Bio Lab 0:0:2 L T P C 20NT3001 VACUUM AND THIN FILM TECHNOLOGY 3 0 0 3 Course objectives: 1. To introduce students to the theory and practice of high vacuum systems as well as thin film deposition 2. To study the physical behavior of gases and the technology of vacuum systems including system operation and design 3. To learn the thin film deposition techniques including physical, chemical methods and its applications in various fields.
    [Show full text]
  • Segmented Solid State Laser Gain Media with Gradient
    Europaisches Patentamt (19) European Patent Office Office europeenpeen des brevets EP 0 655 170 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) intci.6: H01S 3/07, H01S 3/094, of the grant of the patent: H01S3/16 18.12.1996 Bulletin 1996/51 (86) International application number: (21) Application number: 93918690.4 PCT/US93/07423 Date of 05.08.1993 (22) filing: (87) International publication number: WO 94/05062 (03.03.1994 Gazette 1994/06) (54) SEGMENTED SOLID STATE LASER GAIN MEDIA WITH GRADIENT DOPING LEVEL SEGMENTIERTES VERSTAERKUNGSMEDIUM FUER FESTKOERPERLASER MIT GRADIENTENFOERMIGER DOTIERUNGSSTAERKE MILIEUX DE GAIN SEGMENTES A LASER A SOLIDE PRESENTANT UN NIVEAU DE DOPAGE A GRADIENT (84) Designated Contracting States: • SHAND, Michael, L. FR Morristown, NJ 07962 (US) (30) Priority: 17.08.1992 US 930256 (74) Representative: Hucker, Charlotte Jane et al Gill Jennings & Every (43) Date of publication of application: Broadgate House, 31.05.1995 Bulletin 1995/22 7 Eldon Street London EC2M 7LH (GB) (73) Proprietor: AlliedSignal Inc. Morristown, New Jersey 07962-2245 (US) (56) References cited: EP-A- 0 454 865 US-A-3 626 318 (72) Inventors: US-A- 4 860 301 US-A- 5 105 434 • RAPOPORT, William, R. Bridgewater, NJ 08807 (US) DO o lO CO Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice the Patent Office of the Notice of shall be filed in o to European opposition to European patent granted. opposition a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid.
    [Show full text]