Precursors and Chemicals Frequently Used in the Illicit Manufacture Of
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Recommended Methods for the Identification and Analysis of Synthetic Cathinones in Seized Materialsd
Recommended methods for the Identification and Analysis of Synthetic Cathinones in Seized Materials (Revised and updated) MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES Photo credits:UNODC Photo Library; UNODC/Ioulia Kondratovitch; Alessandro Scotti. Laboratory and Scientific Section UNITED NATIONS OFFICE ON DRUGS AND CRIME Vienna Recommended Methods for the Identification and Analysis of Synthetic Cathinones in Seized Materials (Revised and updated) MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES UNITED NATIONS Vienna, 2020 Note Operating and experimental conditions are reproduced from the original reference materials, including unpublished methods, validated and used in selected national laboratories as per the list of references. A number of alternative conditions and substitution of named commercial products may provide comparable results in many cases. However, any modification has to be validated before it is integrated into laboratory routines. ST/NAR/49/REV.1 Original language: English © United Nations, March 2020. All rights reserved, worldwide. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. Mention of names of firms and commercial products does not imply the endorse- ment of the United Nations. This publication has not been formally edited. Publishing production: English, Publishing and Library Section, United Nations Office at Vienna. Acknowledgements The Laboratory and Scientific Section of the UNODC (LSS, headed by Dr. Justice Tettey) wishes to express its appreciation and thanks to Dr. -
Federal Register/Vol. 70, No. 42/Friday, March 4, 2005
Federal Register / Vol. 70, No. 42 / Friday, March 4, 2005 / Notices 10677 Drug Schedule Drug Schedule Therefore, pursuant to 21 U.S.C. 823, and in accordance with 21 CFR 1301.33, Cathinone (1235) .......................... I Alpha-Methylfentanyl (9814) ........ I the above named company is granted Methcathinone (1237) .................. I Acetyl-alpha-methylfentanyl I registration as a bulk manufacturer of N-Ethylamphetamine (1475) ........ I (9815). the basic classes of controlled N,N-Dimethylamphetamine (1480) I Beta-hydroxyfentanyl (9830) ........ I substances listed. Aminorex (1585) ........................... I Beta-hydroxy-3-methylfentanyl I 4-7Methylaminorex (cis isomer) I (9831). Dated: Febuary 22, 2005. (1590). Alpha-Methylthiofentanyl (9832) ... I William J. Walker, Gamma hydroxybutyric acid I 3–Methylthiofentanyl (9833) ......... I Deputy Assistant Administrator, Office of Thiofentanyl (9835) ...................... I (2010). Diversion Control, Drug Enforcement Amphetamine (1100) .................... II Methaqualone (2565) ................... I Administration. Alpha-Ethyltryptamine (7249) ....... I Methamphetamine (1105) ............ II Lysergic acid diethylamide (7315) I Phenmetrazine (1631) .................. II [FR Doc. 05–4205 Filed 3–3–05; 8:45 am] Tetrahydrocannabinols (7370) ..... I Methylphenidate (1724) ................ II BILLING CODE 4410–09–P Mescaline (7381) .......................... I Ambobarbital (2125) ..................... II 3,4,5-Trimethoxyamphetamine I Pentobarbital (2270) ..................... II (7390). -
Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; a Web-Based Approach
ORIGINAL RESEARCH published: 09 February 2021 doi: 10.3389/fpsyt.2020.632405 Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; A Web-Based Approach Valeria Catalani 1*, Davide Arillotta 1, John Martin Corkery 1, Amira Guirguis 1,2, Alessandro Vento 3,4,5 and Fabrizio Schifano 1 1 Psychopharmacology, Drug Misuse & Novel Psychoactive Substances Research Unit, School of Life & Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom, 2 Swansea University Medical School, Institute of Life Sciences 2, Swansea University, Swansea, United Kingdom, 3 Department of Mental Health, ASL Roma 2, Rome, Italy, 4 Addictions’ Observatory (ODDPSS), Rome, Italy, 5 Department of Psychology, Guglielmo Marconi University, Rome, Italy COVID-19-related disruptions of people and goods’ circulation can affect drug markets, especially for new psychoactive substances (NPSs). Drug shortages could cause a change in available NPS, with the introduction of new, unknown, substances. The aims of the current research were to use a web crawler, NPSfinder®, to identify and categorize emerging NPS discussed on a range of drug enthusiasts/psychonauts’ websites/fora at the time of the pandemic; social media for these identified NPS were screened as Edited by: well. The NPSfinder® was used here to automatically scan 24/7 a list of psychonaut Ornella Corazza, University of Hertfordshire, websites and NPS online resources. The NPSs identified in the time frame between United Kingdom January and August 2020 were searched in both the European Monitoring Center Reviewed by: for Drugs and Drug Addictions (EMCDDA)/United Nations Office on Drugs and Crime Simona Zaami, Sapienza University of Rome, Italy (UNODC) databases and on social media (Facebook, Twitter, Instagram, Pinterest, Laura Hondebrink, and YouTube) as well, with a content qualitative analysis having been carried out on University Medical Center reddit.com. -
SENATE BILL No. 259 No
SENATE BILL No. 259 SENATE BILL No. 259 March 10, 2011, Introduced by Senators JONES, CASPERSON and SCHUITMAKER and referred to the Committee on Judiciary. A bill to amend 1978 PA 368, entitled "Public health code," by amending section 7212 (MCL 333.7212), as amended by 2010 PA 171. THE PEOPLE OF THE STATE OF MICHIGAN ENACT: 1 Sec. 7212. (1) The following controlled substances are 2 included in schedule 1: 3 (a) Any of the following opiates, including their isomers, 4 esters, the ethers, salts, and salts of isomers, esters, and 5 ethers, unless specifically excepted, when the existence of these 6 isomers, esters, ethers, and salts is possible within the 7 specific chemical designation: SENATE BILL No. 259 00981'11 TLG 2 1 Acetylmethadol Difenoxin Noracymethadol 2 Allylprodine Dimenoxadol Norlevorphanol 3 Alpha-acetylmethadol Dimepheptanol Normethadone 4 Alphameprodine Dimethylthiambutene Norpipanone 5 Alphamethadol Dioxaphetyl butyrate Phenadoxone 6 Benzethidine Dipipanone Phenampromide 7 Betacetylmethadol Ethylmethylthiambutene Phenomorphan 8 Betameprodine Etonitazene Phenoperidine 9 Betamethadol Etoxeridine Piritramide 10 Betaprodine Furethidine Proheptazine 11 Clonitazene Hydroxypethidine Properidine 12 Dextromoramide Ketobemidone Propiram 13 Diampromide Levomoramide Racemoramide 14 Diethylthiambutene Levophenacylmorphan Trimeperidine 15 Morpheridine 16 (b) Any of the following opium derivatives, their salts, 17 isomers, and salts of isomers, unless specifically excepted, when 18 the existence of these salts, isomers, and salts of -
3,4-Methylenedioxymethcathinone (Methylone) [“Bath Salt,” Bk-MDMA, MDMC, MDMCAT, “Explosion,” “Ease,” “Molly”] December 2019
Drug Enforcement Administration Diversion Control Division Drug & Chemical Evaluation Section 3,4-Methylenedioxymethcathinone (Methylone) [“Bath salt,” bk-MDMA, MDMC, MDMCAT, “Explosion,” “Ease,” “Molly”] December 2019 Introduction: discriminate DOM from saline. 3,4-Methylenedioxymethcathinone (methylone) is a Because of the structural and pharmacological similarities designer drug of the phenethylamine class. Methylone is a between methylone and MDMA, the psychoactive effects, adverse synthetic cathinone with substantial chemical, structural, and health risks, and signs of intoxication resulting from methylone pharmacological similarities to 3,4-methylenedioxymeth- abuse are likely to be similar to those of MDMA. Several chat amphetamine (MDMA, ecstasy). Animal studies indicate that rooms discussed pleasant and positive effects of methylone when methylone has MDMA-like and (+)-amphetamine-like used for recreational purpose. behavioral effects. When combined with mephedrone, a controlled schedule I substance, the combination is called User Population: “bubbles.” Other names are given in the above title. Methylone, like other synthetic cathinones, is a recreational drug that emerged on the United States’ illicit drug market in 2009. It is perceived as being a ‘legal’ alternative to drugs of Licit Uses: Methylone is not approved for medical use in the United abuse like MDMA, methamphetamine, and cocaine. Evidence States. indicates that youths and young adults are the primary users of synthetic cathinone substances which include methylone. However, older adults also have been identified as users of these Chemistry: substances. O H O N CH3 Illicit Distribution: CH O 3 Law enforcement has encountered methylone in the United States as well as in several countries including the Netherlands, Methylone United Kingdom, Japan, and Sweden. -
(19) United States (12) Patent Application Publication (10) Pub
US 20130289061A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0289061 A1 Bhide et al. (43) Pub. Date: Oct. 31, 2013 (54) METHODS AND COMPOSITIONS TO Publication Classi?cation PREVENT ADDICTION (51) Int. Cl. (71) Applicant: The General Hospital Corporation, A61K 31/485 (2006-01) Boston’ MA (Us) A61K 31/4458 (2006.01) (52) U.S. Cl. (72) Inventors: Pradeep G. Bhide; Peabody, MA (US); CPC """"" " A61K31/485 (201301); ‘4161223011? Jmm‘“ Zhu’ Ansm’ MA. (Us); USPC ......... .. 514/282; 514/317; 514/654; 514/618; Thomas J. Spencer; Carhsle; MA (US); 514/279 Joseph Biederman; Brookline; MA (Us) (57) ABSTRACT Disclosed herein is a method of reducing or preventing the development of aversion to a CNS stimulant in a subject (21) App1_ NO_; 13/924,815 comprising; administering a therapeutic amount of the neu rological stimulant and administering an antagonist of the kappa opioid receptor; to thereby reduce or prevent the devel - . opment of aversion to the CNS stimulant in the subject. Also (22) Flled' Jun‘ 24’ 2013 disclosed is a method of reducing or preventing the develop ment of addiction to a CNS stimulant in a subj ect; comprising; _ _ administering the CNS stimulant and administering a mu Related U‘s‘ Apphcatlon Data opioid receptor antagonist to thereby reduce or prevent the (63) Continuation of application NO 13/389,959, ?led on development of addiction to the CNS stimulant in the subject. Apt 27’ 2012’ ?led as application NO_ PCT/US2010/ Also disclosed are pharmaceutical compositions comprising 045486 on Aug' 13 2010' a central nervous system stimulant and an opioid receptor ’ antagonist. -
Pharmacology and Toxicology of Amphetamine and Related Designer Drugs
Pharmacology and Toxicology of Amphetamine and Related Designer Drugs U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES • Public Health Service • Alcohol Drug Abuse and Mental Health Administration Pharmacology and Toxicology of Amphetamine and Related Designer Drugs Editors: Khursheed Asghar, Ph.D. Division of Preclinical Research National Institute on Drug Abuse Errol De Souza, Ph.D. Addiction Research Center National Institute on Drug Abuse NIDA Research Monograph 94 1989 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Alcohol, Drug Abuse, and Mental Health Administration National Institute on Drug Abuse 5600 Fishers Lane Rockville, MD 20857 For sale by the Superintendent of Documents, U.S. Government Printing Office Washington, DC 20402 Pharmacology and Toxicology of Amphetamine and Related Designer Drugs ACKNOWLEDGMENT This monograph is based upon papers and discussion from a technical review on pharmacology and toxicology of amphetamine and related designer drugs that took place on August 2 through 4, 1988, in Bethesda, MD. The review meeting was sponsored by the Biomedical Branch, Division of Preclinical Research, and the Addiction Research Center, National Institute on Drug Abuse. COPYRIGHT STATUS The National Institute on Drug Abuse has obtained permission from the copyright holders to reproduce certain previously published material as noted in the text. Further reproduction of this copyrighted material is permitted only as part of a reprinting of the entire publication or chapter. For any other use, the copyright holder’s permission is required. All other matieral in this volume except quoted passages from copyrighted sources is in the public domain and may be used or reproduced without permission from the Institute or the authors. -
Drugs and Medical Devices Group
The Deputy Administrator of the Drug Enforcement Administration (DEA) issued a notice of intent temporarily placing the substance 2,5-dimethoxy-4-(n)- propylthiophenethylamine (2C-T-7), including its optical isomers, salts, and salts of isomers into Schedule I of the Federal Controlled Substances Act (CSA). 2C-T-7 is structurally related to the Schedule I substance 4-bromo-2,5-dimethoxyphenethylamine (2C-B), and it has those structural features of phenethylamines which are necessary for stimulant and/or hallucinogenic activity. There is no approved therapeutic use of 2C-T-7 in the United States, and the safety of this substance has never been demonstrated. This action was based on the following: (1) 2,5-dimethoxy-4-(n)-propylthiophenethylamine is structurally and pharmacologically related to other Schedule I hallucinogens; (2) 2,5-dimethoxy-4-(n)-propylthiophenethylamine has no accepted therapeutic use in the United States and is not safe for use under medical supervision; and, (3) 2,5-dimethoxy-4-(n)-propylthiophenethylamine has a high potential for abuse, similar to other Schedule I phenethylamines. Pursuant to Section 481.034(g), as amended by the 75th legislature, of the Texas Controlled Substances Act, Chapter 481, Health and Safety Code, at least thirty-one days have expired since notice of the above referenced action was published in the Federal Register, and in my capacity as Commissioner of the Texas Department of Health, I do hereby order that the substance 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7), its optical isomers, salts, and salts of isomers be added to Schedule I of the Texas Controlled Substances Act. -
Federal Register/Vol. 76, No. 228/Monday, November
Federal Register / Vol. 76, No. 228 / Monday, November 28, 2011 / Notices 72975 Dated: November 18, 2011. Drug Schedule (ODL), 8701 Morrissette Drive, Joseph T. Rannazzisi, Springfield, Virginia 22152; and must be Deputy Assistant Administrator, Office of 4-Anilino-N-phenethyl-4-piperidine II filed no later than January 27, 2012. (8333). Diversion Control, Drug Enforcement Dated: November 18, 2011. Administration. Codeine (9050) ............................. II Oxycodone (9143) ........................ II Joseph T. Rannazzisi, [FR Doc. 2011–30547 Filed 11–25–11; 8:45 am] Hydromorphone (9150) ................ II Deputy Assistant Administrator, Office of BILLING CODE 4410–09–P Hydrocodone (9193) ..................... II Diversion Control, Drug Enforcement Levorphanol (9220) ...................... II Administration. Methadone (9250) ........................ II [FR Doc. 2011–30544 Filed 11–25–11; 8:45 am] DEPARTMENT OF JUSTICE Methadone intermediate (9254) ... II BILLING CODE 4410–09–P Morphine (9300) ........................... II Drug Enforcement Administration Thebaine (9333) ........................... II Oxymorphone (9652) ................... II Manufacturer of Controlled DEPARTMENT OF JUSTICE Substances Notice of Application The company plans to manufacture Drug Enforcement Administration Pursuant to § 1301.33(a), Title 21 of the listed controlled substances as bulk the Code of Federal Regulations (CFR), controlled substances intermediates for Manufacturer of Controlled this is notice that on March 30, 2010, distribution to its customers. -
Federal Register/Vol. 75, No. 123/Monday, June 28, 2010/Notices
Federal Register / Vol. 75, No. 123 / Monday, June 28, 2010 / Notices 36681 DEPARTMENT OF JUSTICE Drug Schedule Drug Schedule Drug Enforcement Administration 1-phenylcyclohexylamine (7460) II 1-[1-(2- I Phencyclidine (7471). Thienyl)cyclohexyl]pyrrolidine Manufacturer of Controlled Phenylacetone (8501) .................. II (7473). Substances Notice of Application 1- II 1-Methyl-4-phenyl-4- I piperidinocyclohexanecarbonitri- propionoxypiperidine (9661). Pursuant to § 1301.33(a), Title 21 of le (8603). 1-(2-Phenylethyl)-4-phenyl-4- I the Code of Federal Regulations (CFR), Cocaine (9041) ............................. II acetoxypiperidine (9663). this is notice that on April 29, 2010, Codeine (9050) ............................. II 2,5-Dimethoxy-4-(n)- I Alltech Associates Inc., 2051 Waukegan Dihydrocodeine (9120) ................. II propylthiophenethylamine Road, Deerfield, Illinois 60015, made Ecgonine (9180) ........................... II (7348). application by renewal to the Drug Meperidine intermediate-B (9233) II 2,5-Dimethoxy-4- I Enforcement Administration (DEA) to Noroxymorphone (9668) .............. II ethylamphetamine (7399). 2,5-Dimethoxyamphetamine I be registered as a bulk manufacturer of (7396). the basic classes of controlled The company plans to manufacture 3,4,5-Trimethoxyamphetamine I substances listed in schedules I and II: high purity drug standards used for (7390). analytical application only in clinical, 3,4-Methylenedioxyamphetamine I Drug Schedule toxicological, and forensic laboratories. (7400). 3,4- I Methcathinone (1237) .................. I Any other such applicant, and any Methylenedioxymethamphetam- N-ethylamphetamine (1475) ......... I person who is presently registered with ine (7405). N,N-dimethylamphetamine (1480) I DEA to manufacture such substances, 3,4-Methylenedioxy-N- I 4-methylaminorex (cis isomer) I may file comments or objections to the ethylamphetamine (7404). (1590). issuance of the proposed registration 3-Methylfentanyl (9813) ............... -
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Hallucinogens And Dissociative Drug Use And Addiction Introduction Hallucinogens are a diverse group of drugs that cause alterations in perception, thought, or mood. This heterogeneous group has compounds with different chemical structures, different mechanisms of action, and different adverse effects. Despite their description, most hallucinogens do not consistently cause hallucinations. The drugs are more likely to cause changes in mood or in thought than actual hallucinations. Hallucinogenic substances that form naturally have been used worldwide for millennia to induce altered states for religious or spiritual purposes. While these practices still exist, the more common use of hallucinogens today involves the recreational use of synthetic hallucinogens. Hallucinogen And Dissociative Drug Toxicity Hallucinogens comprise a collection of compounds that are used to induce hallucinations or alterations of consciousness. Hallucinogens are drugs that cause alteration of visual, auditory, or tactile perceptions; they are also referred to as a class of drugs that cause alteration of thought and emotion. Hallucinogens disrupt a person’s ability to think and communicate effectively. Hallucinations are defined as false sensations that have no basis in reality: The sensory experience is not actually there. The term “hallucinogen” is slightly misleading because hallucinogens do not consistently cause hallucinations. 1 ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com ce4less.com How hallucinogens cause alterations in a person’s sensory experience is not entirely understood. Hallucinogens work, at least in part, by disrupting communication between neurotransmitter systems throughout the body including those that regulate sleep, hunger, sexual behavior and muscle control. Patients under the influence of hallucinogens may show a wide range of unusual and often sudden, volatile behaviors with the potential to rapidly fluctuate from a relaxed, euphoric state to one of extreme agitation and aggression. -
Detection of Phenethylamine, Amphetamine, and Tryptamine Imine By-Products from an Acetone Extraction
Detection of Phenethylamine, Amphetamine, and Tryptamine Imine By-Products from an Acetone Extraction Mary A. Yohannan* and Arthur Berrier U.S. Department of Justice Drug Enforcement Administration Special Testing and Research Laboratory 22624 Dulles Summit Court Dulles, VA 20166 [email: mary.a.yohannan -at- usdoj.gov] ABSTRACT: The formation of imine by-products from phenethylamines, amphetamines, and tryptamines upon an acetone extraction is presented. These imine by-products were characterized using GC/MSD and exhibited preferential cleavage at the α-carbon of the alkyl chain. Further characterization of the imine by-products of phenethylamine and tryptamine was done using IR and NMR. KEYWORDS: phenethylamine, tryptamine, imine, acetone, schiff base, drug chemistry, forensic chemistry In most forensic laboratories, the solvents used to extract at the α-carbon on the alkyl chain. In addition to GC/MS, the drugs are chosen based upon their solubility properties and their imines formed from phenethylamine base and tryptamine base ability to not interact with the drug. In fact, there are very few were characterized by Fourier transform-infrared spectroscopy publications where a solvent used to extract a drug reacts with (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. the drug and forms by-products [1-3]. This laboratory recently discovered that an additional Experimental component was formed when acetone was used to extract a Solvents, Chemicals, and Materials sample containing a known tryptamine. Analysis by gas Acetone was ACS/HPLC grade from Burdick and Jackson chromatography/mass spectroscopy (GC/MS) of the acetone Laboratories (Muskegon, MI). Phenethylamine base and extract yielded an extra peak in the total ion chromatogram that tryptamine base were obtained from Sigma-Aldrich Chemicals was approximately half the abundance of the known tryptamine (Milwaukee, WI).