Ageing and Technology
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Biogerontology: a Novel Tool to Stay Healthy in Old Age
MoPAct Policy Brief: 5 Biogerontology: a novel tool to stay healthy in old age Policy priority Healthy lifestyle interventions in particular regarding nutrition and vaccination need to be implemented early in life with a lifecourse perspective. Summary: Key findings: • Accumulating evidence from experimental studies shows that aging is not inevitably linked with the development of chronic diseases. • Only 20-25% of healthy life expectancy (HLE) is predetermined by genes; lifestyle and environment play a major role. • Age-associated accumulation of molecular and cellular damage can be prevented or greatly delayed by lifestyle interventions e.g. dietary manipulations. • Classical strategies (e.g. nutrition, exercise, vaccination) require broad communication to public. • Novel strategies (e.g. dietary interventions, novel drugs, stem cells) need successful translation from the understanding of molecular mechanism to animal models to clinic. • To be successful interventions need to be started early Figure 1. Strategies to increase HLE. (1) Classical interventions include nutrition, exercise, vaccination, no smoking/alcohol/drugs. (2) Novel interventions include in life with a life-course perspective. dietary interventions, clearance of senescent and damaged cells, mitohormetics, stem cells, drugs against inflammation, rejuvenation factors from blood, telomeres, Background: epigenetic drugs, chaperons and proteolytic systems (novel interventions adapted from López-Otín et al., Cell 2013). Population aging is progressing fast in all developed countries. Aging is associated with the development of multiple serious chronic illnesses, including type 2 diabetes, hypertension, heart Prevention disease, stroke, cancer, cognitive impairment and increased Prevention prior to the development of age-associated diseases morbidity and mortality from infectious diseases. As people is key for successful aging. -
Gerontology (GERO) 1
Gerontology (GERO) 1 GERO 3775 Dementia 3 s.h. GERONTOLOGY (GERO) The understanding of the nature, causes, symptoms, and social consequences of dementia. Attention to the status of aging, caregiving, and to the status of GERO 1501 Introduction to Gerontology 3 s.h. those who suffer from dementia in contemporary society. Basic introduction to the interdisciplinary study of aging. Includes social, Prereq.: GERO 1501 or SOC 1500. psychological, economic, cultural, health, and policy issues. Discussion of GERO 3790 Aging in Cross-Cultural Perspective 3 s.h. normal vs. abnormal (disease-related) aspects of aging. Examines the phenomenon of aging from cross-cultural perspectives with Gen Ed: Social Science. an emphasis on cultural evolution and it's impact upon the status, roles and GERO 3703 Aging and Society 3 s.h. cultural values associated with aging and the aged. Listed also as SOC 3790 An interdisciplinary introduction to studies in aging. Examines the impact of and ANTH 3790. population aging and its effect on society at large. Also examines individual Prereq.: GERO 1501 or ANTH 1500, or SOC 1500. aging processes and social significance of aging. Listed also as SOC 3703. GERO 4801 Later Life Issues 3 s.h. Prereq.: SOC 1500 or GERO 1501. The course is designed as an advanced course in the issues of later life and Gen Ed: Social Science, Well Being, Social and Personal Awareness. long term care services and supports. Cross-Listed: SOC 4801. GERO 3745 Sociology of Health, Illness, and Healthcare 3 s.h. Prereq.: GERO 3703 OR SOC 3703. Social attitudes toward illness. -
Shared Ageing Research Models (Sharm): a New Facility to Support Ageing Research
Biogerontology (2013) 14:789–794 DOI 10.1007/s10522-013-9457-0 METHOD Shared Ageing Research Models (ShARM): a new facility to support ageing research Adele L. Duran • Paul Potter • Sara Wells • Tom Kirkwood • Thomas von Zglinicki • Anne McArdle • Cheryl Scudamore • Qing-Jun Meng • Gerald de Haan • Anne Corcoran • Ilaria Bellantuono Received: 5 July 2013 / Accepted: 16 August 2013 / Published online: 2 October 2013 Ó The Author(s) 2013. This article is published with open access at Springerlink.com Abstract In order to manage the rise in life expec- Wellcome Trust, open to all investigators. It collects, tancy and the concomitant increased occurrence of stores and distributes flash frozen tissues from aged age-related diseases, research into ageing has become murine models through its biorepository and provides a strategic priority. Mouse models are commonly a database of live ageing mouse colonies available in utilised as they share high homology with humans and the UK and abroad. It also has an online environment show many similar signs and diseases of ageing. (MICEspace) for collation and analysis of data from However, the time and cost needed to rear aged communal models and discussion boards on subjects cohorts can limit research opportunities. Sharing of such as the welfare of ageing animals and common resources can provide an ethically and economically endpoints for intervention studies. Since launching in superior framework to overcome some of these issues July 2012, thanks to the generosity of researchers in but requires dedicated infrastructure. Shared Ageing UK and Europe, ShARM has collected more than Research Models (ShARM) (www.ShARMUK.org) 2,500 tissues and has in excess of 2,000 mice regis- is a new, not-for-profit organisation funded by tered in live ageing colonies. -
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Article Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis Graphical abstract Authors Christopher D. Wiley, Rishi Sharma, Sonnet S. Davis, ..., Marco Demaria, Arvind Ramanathan, Judith Campisi Correspondence [email protected] (C.D.W.), [email protected] (A.R.), [email protected] (J.C.) In brief Senolytics, transgenic, and pharmacological interventions that selectively kill senescent cells are currently in clinical trials aiming to treat age-related degenerative pathologies. Here, Wiley et al. discover that senescent cells produce multiple signaling lipids known as oxylipins. One oxylipin, dihomo-15d-PGJ2, promotes features of senescence by activating RAS and is released from cells during senolysis, serving as the first biomarker of the Highlights process in culture and in vivo. d Senescent cells make several oxylipins, dihomo- prostaglandins, and leukotrienes d Dihomo-15d-PGJ2 is intracellular during senescence and released during senolysis d Dihomo-15d-PGJ2 activates RAS, promoting senescence and the SASP d Positive feedback between prostaglandins, RAS, and p53 maintains senescence Wiley et al., 2021, Cell Metabolism 33, 1–13 June 1, 2021 ª 2021 Published by Elsevier Inc. https://doi.org/10.1016/j.cmet.2021.03.008 ll Please cite this article in press as: Wiley et al., Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis, Cell Metabolism (2021), https://doi.org/10.1016/j.cmet.2021.03.008 ll Article Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis Christopher D. Wiley,1,2,* Rishi Sharma,1 Sonnet S. Davis,1 Jose Alberto Lopez-Dominguez,1 Kylie P. Mitchell,1 Samantha Wiley,1 Fatouma Alimirah,1 Dong Eun Kim,1 Therese Payne,1 Andrew Rosko,1 Eliezer Aimontche,1 Sharvari M. -
1 CURRICULUM VITAE: Robert B. Hudson Boston University School Of
CURRICULUM VITAE: Robert B. Hudson Boston University School of Social Work 264 Bay State Road, Boston, MA 02215 Tele: (617) 353-3759 e-mail: [email protected] EDUCATION Ph.D. University of North Carolina at Chapel Hill; May, 1972 Political Science B.A. Washington and Lee University; June, 1966 EMPLOYMENT Professor of Social Welfare Policy School of Social Work Boston University (1985-Present) Acting Director, SOC/SSW Doctoral Program, 2010 Acting Associate Dean for Academic Affairs (1995-96) Chair, Department of Social Welfare Policy (1988-2014) Associate Professor of Social Policy Graduate School of Social Service Fordham University (1981-1985) Assistant Professor of Politics & Social Welfare Florence Heller Graduate School Brandeis University (1972-1981) AWARDS AND HONORS Visiting Professor, University of Melbourne, 2006. Boston University School of Social Work, Award in Teaching Excellence, 2002-03 Chair, John A. Heinz Dissertation Award Committee, National Academy of Social Insurance, 1999-2010. AWARDS AND HONORS (cont’d.) 1 Donald P. Kent Award, Gerontological Society of America, 1996 Fellow, Employee Benefit Research Institute, 1996 Arthur S. Flemming Award, National Association of State Units on Aging, 1995 Member, Board of Directors, National Academy on an Aging Society, 1995-. Elected Member, National Academy of Social Insurance, 1994 Board of Directors, American Society on Aging, 1990-1993 Chair, Social Research, Planning and Practice Section, Gerontological Society of America, 1988. Fellow, Gerontological Society of America, 1977 Research Career Development Award, National Institute on Aging, National Institutes of Health, 1977-82 Dissertation Research Grant, National Science Foundation, 1970 PUBLICATIONS Hudson, R.B. Forthcoming. Aging politics and policy in the United States. -
HCB 524 — Transhumanism
HCB 524 Special Topic in Bioethics Fall Semester, 2019. Tuesdays 6-8:30pm. Instructor of Record: Adam Sepe, MA, MLS(ASCP)cm [email protected] Course Description: Transhumanism and [Human?] Dignity. Throughout human history — and prehistory for that matter — technological advancement has drastically altered every aspect of human life. Most of us will say that many advents — such as cooking and the wheel — have been largely, if not entirely, beneficial. Would we say the same of all technology? Surely each of us can list technologies that have, in the very least, some considerable downsides. So while history and experience can tell us that some technologies are beneficial and that some other technologies are harmful, how can we know what kind of impact future technology will have? For now we can’t, and so all we can do is try, to the best of our ability, to imagine such futures and develop our technology with these considerations in mind. ‘Transhumanism’ refers a diverse collection of ideas that have one at least thing in common: through future technology, humanity will be fundamentally altered to an unprecedented degree. Some even believe there will come a time when, through our own action, the word ‘human’ will be obsolete; that we will be succeeded by entities (or an entity) for which ‘human’ does not apply. Most people who identify as transhumanists are, to varying degrees, proponents of such technology. They are in favor of such alterations and they argue that these will be beneficial. In this course, we will take a critical look at transhumanist claims. -
2017 Focus on Faculty Publication
FOCUS ON FACULTY 2017 MESSAGE FROM THE INTERIM PRESIDENT It is my great pleasure to recognize and celebrate the scholarship, teaching, service and overall excellence of our faculty at Bellarmine University. I am profoundly grateful for our faculty’s devotion to classroom instruction that challenges students, and for their support in helping our students to meet those challenges. This volume, however, demonstrates the considerable time, imagination and energy that our faculty give to pursuits beyond the class- room—researching, publishing, creating works of art, leading study-abroad courses and service-learning trips, and providing expertise in the community. These and other accomplishments have allowed Bellarmine University to become a private institution of significant stature—the premier Catholic uni- versity in the South and the leading private institution in the Commonwealth and region. We are proud to showcase our faculty in this publication, which is organized around these goals of Bellarmine’s Strategic Plan: • Celebrate our Catholic identity in the inclusive Merton spirit as the founda- tion of our commitment to student fulfillment, global consciousness and environmental sustainability; • Establish and sustain a climate of excellence throughout the university; • Integrate an international focus and sensibility into all curricular and co-curricular programs; and • Enhance our reputation, expand our market and dramatically grow our enrollment. Achievements listed here represent work that was completed from the fall of 2015 through the end of calendar 2016. They vividly illustrate how Bellar- mine’s excellent faculty bring our mission to life—by educating talented, diverse students of many faiths, ages, nations, and cultures, and also through their scholarship and service. -
Gerontology (GERN)
Gerontology (GERN) GERN 438 PSYCHOLOGICAL ASPECTS OF DISABILITY (3-4) This course is designed to give participants a better understanding of people with GERN 300 THE JOURNEY OF ADULTHOOD (3) disabilities and an awareness of how society regards them. The disabilities ad- Introduces the study of aging from biological, psychological, sociological, and envi- dressed range from traumatic physical injuries through progressive diseases and ronmental perspectives. Aging is presented as a normal state of development with conditions to mental retardation, alcoholism and emotional disabilities. The class is both positive and negative aspects. Specific issues discussed include: health care, appropriate for anyone interested in disability, whether for personal or professional housing, income maintenance, and advocacy. Satisfies GE Area E (The Integrated reasons. Crosslisted with PSY 438. Person). GERN 482 TEACHING INTERNSHIP (1-4) GERN 317 EMOTIONS AND ADULT LIFE (4) Students learn the skills of organization and communication of psychological Emphasizes the social context and social development of emotional responses theory and research under the supervision of a faculty mentor. Prerequisites: GERN throughout adulthood. Analyzes the reciprocal relations between social defini- 300 and consent of instructor. tions and subjective feelings in connection with life events throughout adulthood. GERN 490 INTERNSHIP SEMINAR (1) Addresses both basic emotions, such as fear, anger, pleasure, and excitement, and In this optional seminar, students report on the progress of their internships and more complex emotions, such as love, jealousy, grief, sympathy, pride, shame, and discuss institutional procedures and interactional processes particular to their despair. Cross-listed as SOCI 317. Satisfies GE Area E (The Integrated Person). intern sites. -
Syllabus 2018
FINAL DRAFT Summer One Semester 2018 HCB 504 BIOTECHNOLOGY: Special Topics Room 067 Mondays, Tuesday, Thursdays 6 – 8:30 pm Instructor of Record: Migdal, Kobba, Post Phyllis Migdal, MD MA [email protected] Timothy Kobba MA [email protected] Stephen Post PhD [email protected] Course Description: Dignity and Biomedical Aspirations – Therapy, Enhancement & Transhumanism The three “supers” of transhumanism are not just “science fiction.” Super-longevity, super-happiness, and super-intelligence, along with perfect babies, are works-in-progress at the interface of “old” evolved human nature as we have known it and technical progress toward the posthuman of our own creation. With the astonishing biotechnological powers that are increasingly reshaping nature and human nature, are we in a “transitional state” (transhumanism) en route to a redesigned posthuman future in which current limitations are overcome? Four centuries ago, Francis Bacon announced the biological utopia of the future in his The New Atlantis, replete with fountains of youth and chimeras. The term “transhumanism” was originally coined by the British biologist philosopher Julian Huxley in a 1957 essay to capture the ways in which social institutions could supplant evolution in refining and improving the species, as could technology. Sensory perception, emotive ability, cognitive capacity, health and life spans could all be augmented. The term was taken over in the 1990s by British philosopher Max More, who began defining the principles -
Tracing the Historical Growth of Gerontology
Educational Considerations Volume 8 Number 1 Article 3 9-1-1980 Tracing the historical growth of gerontology David B. Oliver Jocelyn M. Eckerman Richard S. Machalek Follow this and additional works at: https://newprairiepress.org/edconsiderations Part of the Higher Education Commons This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License. Recommended Citation Oliver, David B.; Eckerman, Jocelyn M.; and Machalek, Richard S. (1980) "Tracing the historical growth of gerontology," Educational Considerations: Vol. 8: No. 1. https://doi.org/10.4148/0146-9282.1832 This Article is brought to you for free and open access by New Prairie Press. It has been accepted for inclusion in Educational Considerations by an authorized administrator of New Prairie Press. For more information, please contact [email protected]. Oliver et al.: Tracing the historical growthcannot of gerontologybe questioned. Researchers and service providers, The question of whether regard less of their academic backgrounds and experience have special significant and mutual concerns which tend gerontology is an emerging to suggest that gerontology may indeed qualify as a new branch of knowledge. Some of these underlying thema new discipline or a variation include an examination of variables which contribute to or hinder the quality of an individual's life in old age, a concern for the social environment and its impact on per of older ones sons who are increasingly being separated from it, the psychological consequences of retirement as one o f the is being debated. last major rites of passage, the social world of widows and widowers who after a lifetime of sharing now face life as singles in a cou ple-oriented culture, changes in health (physical and mental) which may not diminish one's ability to function normally in old age, and so on. -
Living to 100”
The Likelihood and Consequences of “Living to 100” Leonard Hayflick, Ph.D. Professor of Anatomy, Department of Anatomy University of California, San Francisco, School of Medicine Phone: (707) 785-3181 Fax: (707) 785-3809 Email: [email protected] Presented at the Living to 100 Symposium Orlando, Fla. January 5-7, 2011 Copyright 2011 by the Society of Actuaries. All rights reserved by the Society of Actuaries. Permission is granted to make brief excerpts for a published review. Permission is also granted to make limited numbers of copies of items in this monograph for personal, internal, classroom or other instructional use, on condition that the foregoing copyright notice is used so as to give reasonable notice of the Society’s copyright. This consent for free limited copying without prior consent of the Society does not extend to making copies for general distribution, for advertising or promotional purposes, for inclusion in new collective works or for resale. Abstract There is a common belief that it would be a universal good to discover how to slow or stop the aging process in humans. It guides the research of many biogerontologists, the course of some health policy leaders and the hopes of a substantial fraction of humanity. Yet, the outcome of achieving this goal is rarely addressed despite the fact that it would have profound consequences that would affect virtually every human institution. In this essay, I discuss the impact on human life if a means were found to slow our aging process, thus permitting a life expectancy suggested by the title of this conference, “Living to 100.” It is my belief that most of the consequences would not benefit either the individual or society. -
2 the Biology of Ageing
The biology of ageing 2 Aprimer JOAO˜ PEDRO DE MAGALHAES˜ OVERVIEW .......................................................... This chapter introduces key biological concepts of ageing. First, it defines ageing and presents the main features of human ageing, followed by a consideration of evolutionary models of ageing. Causes of variation in ageing (genetic and dietary) are reviewed, before examining biological theories of the causes of ageing. .......................................................... Introduction Thanks to technological progress in different areas, including biomed- ical breakthroughs in preventing and treating infectious diseases, longevity has been increasing dramatically for decades. The life expectancy at birth in the UK for boys and girls rose, respectively, from 45 and 49 years in 1901 to 75 and 80 in 1999 with similar fig- ures reported for other industrialized nations (see Chapter 1 for further discussion). A direct consequence is a steady increase in the propor- tion of people living to an age where their health and well-being are restricted by ageing. By the year 2050, it is estimated that the per- centage of people in the UK over the age of 65 will rise to over 25 per cent, compared to 14 per cent in 2004 (Smith, 2004). The greying of the population, discussed elsewhere (see Chapter 1), implies major medical and societal changes. Although ageing is no longer considered by health professionals as a direct cause of death (Hayflick, 1994), the major killers in industrialized nations are now age-related diseases like cancer, diseases of the heart and 22 Joao˜ Pedro de Magalhaes˜ neurodegenerative diseases. The study of the biological mechanisms of ageing is thus not merely a topic of scientific curiosity, but a crucial area of research throughout the twenty-first century.