Page 1 of 6 Science/AAAS | Table of Contents: 18 December 2009; 326

Total Page:16

File Type:pdf, Size:1020Kb

Page 1 of 6 Science/AAAS | Table of Contents: 18 December 2009; 326 Science/AAAS | Table of Contents: 18 December 2009; 326 (5960) Page 1 of 6 Enter Search Term ADVANCED AAAS.ORG FEEDBACK HELP LIBRARIANS Science Magazine NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY ALERTS | ACCESS RIGHTS | MY ACCOUNT | SIGN IN Science Home Current Issue Previous Issues Science Express Science Products My Science About the Journal Home > Science Magazine > Issue Archive > 2009 > 18 December 2009 ADVERTISEMENT 18 DECEMBER 2009 VOL 326, ISSUE 5960, PAGES 1577-1744 Special Issue Letters Brevia This Week in Science Books et al. Research Articles Editorial Education Forum Reports Editors' Choice Perspectives News of the Week Association Affairs News Focus Front and Back Matter from the Print Issue [PDF] About the Cover ADVERTISEMENT Author Index Subject Index Set E-Mail Alerts Order an Issue/Article RSS Feeds Search the Journal Issue Highlights Enter Keyword 2009 Breakthrough of the Year Silent Hate This issue only Universal Few-Body Binding Home is Where the Hearth Is Special Issue For all checked items Breakthrough of the Year Video: Ardipithecus ramidus Science 18 December 2009: 1598. A video introduction to the year's top science story, featuring scientists C. Owen Lovejoy, Tim White, Giday WoldeGabriel, Yohannes Haile-Selassie, Science contributing correspondent Ann Gibbons, and commentary by paleoanthropologist Andrew Hill. Summary » Full Text » News BREAKTHROUGH OF THE YEAR Ardipithecus ramidus Ann Gibbons Science 18 December 2009: 1598-1599. A rare 4.4-million-year-old skeleton has drawn back the curtain of time to reveal the surprising body plan and ecology of our earliest ancestors. Summary » Full Text » PDF » BREAKTHROUGH OF THE YEAR The Runners-Up The News Staff Science 18 December 2009: 1600-1607. This year's runners-up for Breakthrough of the Year include new gamma-ray observations, the long-sought receptor for a key plant hormone, mock monopoles, a drug that increases life span, ice on the moon, gene-therapy successes, insights into the properties of To Advertise Find Products graphene and how to use it to make novel devices, Hubble's rebirth, and the first x-ray laser. Summary » Full Text » PDF » ADVERTISEMENT SCORECARD Rating Last Year's Areas to Watch Science 18 December 2009: 1602. Science's editors clearly foresaw this year's burgeoning of plant genome sequences, progress on emissions reductions in the run-up to the U.N. conference in Copenhagen, and the continued failure to spot dark matter. Last year's other predictions will take more time to come to fruition. Summary » Full Text » PDF » BREAKDOWN REVISITED Trying to Stay Afloat Jeffrey Mervis and Eliot Marshall Science 18 December 2009: 1604-1605. The global financial crisis made 2009 a tough year for many U.S. academic institutions dependent on state funding or endowments. But it has also been a banner year for thousands of individual scientists, whose labs have benefited from billions of dollars in U.S. government stimulus funding. Summary » Full Text » PDF » BREAKTHROUGH OF THE YEAR Areas to Watch Science 18 December 2009: 1606. http://www.sciencemag.org/content/vol326/issue5960/index.dtl 13/7/2553 Science/AAAS | Table of Contents: 18 December 2009; 326 (5960) Page 2 of 6 FEATURED JOBS In 2010, Science's editors will be watching for developments with induced pluripotent stem cells, the Alpha Magnetic Spectrometer, "exome sequencing," disrupting the metabolism of tumor cells, and human space flight. Summary » Full Text » PDF » VIRUS OF THE YEAR The Novel H1N1 Influenza Martin Enserink and Jon Cohen Science 18 December 2009: 1607. For years, scientists have been warning about the potential for an influenza pandemic on the order of the 1918 Spanish flu. But the pandemic that erupted last spring looks nothing like the one health officials have been preparing to combat. Summary » Full Text » PDF » Contents For all checked items This Week in Science Editor summaries of this week's papers. Science 18 December 2009: 1587. Full Text » EDITORIAL: The Breakthroughs of 2009 Bruce Alberts Science 18 December 2009: 1589. Summary » Full Text » PDF » Editors' Choice Highlights of the recent literature. Science 18 December 2009: 1590. Full Text » Science Podcast Science 18 December 2009: 1715. The show includes the year's top scientific breakthroughs and the 2009 virus of the year. Summary » Full Text » Transcript » New Products Science 18 December 2009: 1715. A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers. Summary » Full Text » PDF » News of the Week 2010 U.S. BUDGET Congress Takes Care of Science In Quiet Finish to a Busy Year Jeffrey Mervis Science 18 December 2009: 1608. Congress has quietly passed a 2010 spending bill that gives several U.S. science agencies pretty much what they expected, including a 2.3% bump for the National Institutes of Health and a 6.7% increase for the National Science Foundation. Summary » Full Text » PDF » ACADEMIC FREEDOM Terrorism Charges Against Grad Student Raise Questions Greg Miller Science 18 December 2009: 1609. Last month a sociology graduate student at the University of Minnesota, Twin Cities, was charged with conspiracy under the Animal Enterprise Terrorism Act after he refused to testify before a grand jury that is apparently investigating a laboratory break-in at the University of Iowa in 2004. Summary » Full Text » PDF » SCIENTIFIC INTEGRITY A Dark Tale Behind Two Retractions Robert F. Service Science 18 December 2009: 1610-1611. Two papers from a prominent chemistry lab were retracted from Science and the Journal of the American Chemical Society this fall because the results couldn't be replicated. The story behind the retractions involves an extortion attempt and a threat of suicide. Summary » Full Text » PDF » U.S. SCIENCE POLICY Chair of Science Panel to Leave Congress Jeffrey Mervis Science 18 December 2009: 1611. Representative Bart Gordon (D–TN), the chair of the House Science and Technology Committee, announced this week that he will retire at the end of 2010, ending a 26-year career in Congress. Summary » Full Text » PDF » SCIENCENOW.ORG From Science's Online Daily News Site Science 18 December 2009: 1611. ScienceNOW reported this week that HIV has outwitted yet another microbicide, the discovery of a cheap way to chop up nitrogen and a way to make large amounts of an elusive type of nanotube, and that people who perceive numbered sequences as visual patterns have superior memories, among other stories. Summary » Full Text » PDF » http://www.sciencemag.org/content/vol326/issue5960/index.dtl 13/7/2553 Science/AAAS | Table of Contents: 18 December 2009; 326 (5960) Page 3 of 6 EVOLUTION Spineless Fish and Dark Flies Prove Gene Regulation Crucial Elizabeth Pennisi Science 18 December 2009: 1612. On page 1663 of this week's issue of Science and in last week's Science Express, two teams independently report that changes in regulatory DNA were responsible for an adaptation in natural populations of fish and insects. Each group has also pieced together details of the underlying genetic alterations in those animals. Summary » Full Text » PDF » FRANCE Sarkozy's 'Grand Loan' Bets That Research Will Pay Off Martin Enserink Science 18 December 2009: 1613. On Monday, president Nicolas Sarkozy announced a 35 billion investment plan that he pledged would make France's science more productive, its population smarter, its economy more competitive, and its environment cleaner. Summary » Full Text » PDF » SCIENCEINSIDER From the Science Policy Blog Science 18 December 2009: 1613. This week, ScienceInsider offers a comprehensive look at the political climate for the climate-change debate in the U.S. Senate, including interviews with the key players, analysis of the biggest issues, and a look at where the votes are, among other stories. Summary » Full Text » PDF » Random Samples Science 18 December 2009: 1597. Full Text » News Focus GEOLOGY Peril in the Pamirs Richard Stone Science 18 December 2009: 1614-1617. Concerns about the risk of a calamitous flood from a mountain lake in Central Asia have scientists racing to improve evacuation plans and find an engineering fix. Summary » Full Text » PDF » GEOLOGY Burdened by Soviet Legacy, Nations Spar Over Water Rights Richard Stone Science 18 December 2009: 1616. As scientists worry about the prospect of a catastrophic flood from Lake Sarez in the Pamir Mountains (see main text), agricultural communities on the plains below face a very different problem: increasing competition for fresh water, a situation that might be eased, experts say, if Lake Sarez could be tapped and its surplus water distributed. Summary » Full Text » PDF » MARINE SCIENCES U.S. Poised to Adopt National Ocean Policy Erik Stokstad Science 18 December 2009: 1618. Faced with more action in the ocean, a new federal council will try to improve planning and resolve conflicts. Summary » Full Text » PDF » CANCER RESEARCH Melanoma Drug Vindicates Targeted Approach Ken Garber Science 18 December 2009: 1619. A mutation-targeted molecular therapy has shown promise against one of the most devastating types of cancer, but how it works is unclear. Summary » Full Text » PDF » GENOMICS Ecological Genomics Gets Down to Genes—and Function Elizabeth Pennisi Science 18 December 2009: 1620-1621. The promise of genomics has been luring ecologists into the once-alien world of molecular biology. Summary » Full Text » PDF » Letters Time for DNA Disclosure D. E. Krane, V. Bahn, D. Balding, B. Barlow, H. Cash, B. L. Desportes, P. D'Eustachio, K. Devlin, T. E. Doom, I. Dror, S. Ford, C. Funk, J. Gilder, G. Hampikian, K. Inman, A. Jamieson, P. E. Kent, R. Koppl, I. Kornfield, S. Krimsky, J. Mnookin, L. Mueller, E. Murphy, D. R. Paoletti, D. A. Petrov, M. Raymer, D. M. Risinger, A. Roth, N. Rudin, W. Shields, J. A. Siegel, M. Slatkin, Y. S. Song, T. Speed, C. Spiegelman, P. Sullivan, A. R. Swienton, T.
Recommended publications
  • IMRE BARTOS Associate Professor of Physics | University of Florida | People.Clas.Ufl.Edu/Imrebartos
    IMRE BARTOS Associate Professor of Physics | University of Florida | people.clas.ufl.edu/imrebartos RESEARCH INTEREST Gravitational wave astrophysics, multi-messenger astrophysics, high-energy astroparticle physics, black hole and neutron star evolution and interactions, cosmology. EDUCATION AND TRAINING Columbia University Physics (Szabolcs Marka) PhD 2012 Eotvos University, Hungary Physics Diploma 2006 PROFESSIONAL APPOINTMENTS Associate Professor University of Florida 2021—present Assistant Professor University of Florida 2017—2021 Associate Research Scientist Columbia University 2016—2017 Lecturer in Discipline Columbia University 2012—2016 HONORS AND AWARDS Alfred P. Sloan Foundation Research Fellowship 2020—2022 Excellence Award for Assistant Professors, University of Florida 2020 Columbia Science Fellow, Columbia University 2012—2016 Allan M. Sachs Teaching Award 2011 Columbia Presidential Teaching Award, Finalist 2012 National Science Foundation Highlights 2014 AAS Nova Highlight 2016 5 Favorite Features of the year, Physics World 2018 Brookhaven National Lab Distinguished Lecture 2016 Rising Stars of Science: The Forbes 30 Under 30 (Forbes Magazine) 2012 Summer Undergraduate Research Fellowship, Caltech 2004 As a member of the LIGO Scientific Collaboration: Special Breakthrough Prize in Fundamental Physics 2016 Gruber Cosmology Prize 2016 Princess of Asturias Award for Technical and Scientific Research 2017 Einstein Medal from the Einstein Society in Bern, Switzerland 2017 Bruno Rossi Prize 2017 Science’s Breakthrough of the
    [Show full text]
  • Kyung Ha Lee
    Kyung Ha Lee Phone: +82-31-290-7042, Email: [email protected] Academic Activities Sungkyunkwan University, Department of Physics, Suwon, South Korea Assistant Professor Sep. 2020 – Present Relevant Area of Science: Gravitational Wave Research (LIGO) Stanford University, Applied Physics, California, United States Postdoc in Applied Physics Feb. 2019 – Aug. 2020 Research Group: Ginzton Laboratory, Martin Fejer Group Relevant Area of Science: Gravitational Wave Research (LIGO) University of Glasgow, School of Physics and Astronomy, Glasgow, United Kingdom Ph.D. in Physics Oct. 2014 – Jan. 2019 Research Group: Institute for Gravitational Research (IGR) Relevant Area of Science: Gravitational Wave Research (LIGO) Seoul National University, School of Physics and Astronomy, Seoul, South Korea Researcher Jun. 2012 – May. 2013 Research Group: RENO Collaboration Relevant Area of Science: Neutrino Oscillation Experiment California Institute of Technology (Caltech), Department of Physics, Pasadena, CA. USA B.S. in Physics with Honor Oct. 2007 – Jun. 2011 Relevant Area of Science: Gravitational Wave Research (LIGO) Awards and Scholarship - Scottish Universities Physics Alliance (SUPA) Prize Studentship (2014) o This studentship is for 3.5 years and provides annual maintenance allowance, annual RTSG (Research Training Support Grant), and full cost of university tuition fees. - Thomson Experimental Prize (2017) o This prize was founded in 1869 by William Thomson later created 1st Baron Kelvin. It is awarded on the recommendation of the Professor of Natural
    [Show full text]
  • New Contract Award
    TRI-Supported Trial Named Science Magazine’s 2011 “Breakthrough of the Year” Bethesda, Maryland (May 18, 2012): Technical Resources International, Inc. (TRI) is proud to have provided regulatory, safety, and technical support to the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID), NIH for the HIV clinical trial that was chosen as the 2011 Breakthrough of the Year by Science Magazine. The NIAID-sponsored HPTN 052 study was an international HIV prevention trial conducted in nine countries. Investigators conducting the study reported that HIV-infected heterosexual individuals who began taking antiretroviral medicines when their immune systems were relatively healthy were 96 percent less likely to transmit the virus to their uninfected partners. Federal officials and the medical community are advocating a ‘treatment-as-prevention’ approach be included as a key component of public health policies due in large part to the results of HPTN 052. They also indicate these findings will have positive implications in domestic and public health in the coming years and even suggest that achieving an end to the HIV/AIDS pandemic is now feasible. About NIAID: NIAID is working to end the HIV/AIDS epidemic by advancing basic knowledge of the pathogenesis and transmission of HIV, supporting the improvement of therapies for HIV infection and its complications, and supporting the development of HIV/AIDS vaccines and other prevention measures. NIAID sponsors Phase I, II, III and IV clinical trials to assess the safety and efficacy of therapeutics, vaccines, and other preventive modalities. Currently, NIAID funds more than 300 HIV/AIDS clinical trials in more than 50 countries at more than 1,000 domestic and international clinical research sites.
    [Show full text]
  • Evaluating the Efficiency of Grnas in CRISPR/Cas9 Mediated Genome
    International Journal of Molecular Sciences Article Evaluating the Efficiency of gRNAs in CRISPR/Cas9 Mediated Genome Editing in Poplars Tobias Bruegmann * , Khira Deecke and Matthias Fladung * Thuenen Institute of Forest Genetics, Sieker Landstrasse 2, D-22927 Grosshansdorf, Germany * Correspondence: [email protected] (T.B.); matthias.fl[email protected] (M.F.) Received: 21 June 2019; Accepted: 21 July 2019; Published: 24 July 2019 Abstract: CRISPR/Cas9 has become one of the most promising techniques for genome editing in plants and works very well in poplars with an Agrobacterium-mediated transformation system. We selected twelve genes, including SOC1, FUL, and their paralogous genes, four NFP-like genes and TOZ19 for three different research topics. The gRNAs were designed for editing, and, together with a constitutively expressed Cas9 nuclease, transferred either into the poplar hybrid Populus canescens × or into P. tremula. The regenerated lines showed different types of editing and revealed several homozygous editing events which are of special interest in perennial species because of limited back-cross ability. Through a time series, we could show that despite the constitutive expression of the Cas9 nuclease, no secondary editing of the target region occurred. Thus, constitutive Cas9 expression does not seem to pose any risk to additional editing events. Based on various criteria, we obtained evidence for a relationship between the structure of gRNA and the efficiency of gene editing. In particular, the GC content, purine residues in the gRNA end, and the free accessibility of the seed region seemed to be highly important for genome editing in poplars. Based on our findings on nine different poplar genes, efficient gRNAs can be designed for future efficient editing applications in poplars.
    [Show full text]
  • BREAKTHROUGH of the YEAR: Areas to Watch -- 318 (5858): 1848 -- Science 1/15/08 7:33 PM
    BREAKTHROUGH OF THE YEAR: Areas to Watch -- 318 (5858): 1848 -- Science 1/15/08 7:33 PM Current Issue Previous Issues Science Express Science Products My Science About the Journal Home > Science Magazine > 21 December 2007 > pp. 1848 - 1849 Science 21 December 2007: ADVERTISEMENT Vol. 318. no. 5858, pp. 1848 - 1849 DOI: 10.1126/science.318.5858.1848 NEWS BREAKTHROUGH OF THE YEAR: Areas to Watch Gray matter no more. Colorful labeling methods should help researchers map out neural circuits. CREDIT: LIVET ET AL., NATURE 450, 7166 (2007) ADVERTISEMENT A smashing start? Next summer, physicists will start up the Large Hadron Collider (LHC) at the European particle physics lab, CERN, outside Geneva, Switzerland. Researchers hope this highest- energy collider will reveal plenty of new particles and puzzles, but the immediate question is how fast will it come on? The ultracomplex machine runs at a frigid 1.9 kelvin, and if for some reason researchers have to warm part of it up, it will take months to cool it again. Still, CERN has a record of bringing new machines on line smoothly. Call it a major success if the LHC produces even a little data next year. See Web links on the LHC Micromanagers. Research on small RNA molecules that control gene expression continues at a rapid clip, and microRNAs are surging to the front of the pack. Roughly 800 papers on the tiny molecules were published in 2007, tying them to a slew of cancers, heart ailments, a healthy immune system, stem cell differentiation, and more. But it's still early days.
    [Show full text]
  • Science Magazine: Evolution in Action (2005)
    Breakthrough of the Year Equipped with genome data and field observations of organisms from microbes to mammals, biologists made huge strides toward understanding the mechanisms by which living creatures evolve Evolution in Action The big breakthrough, of course, was the basic facts of evolution. With all this in of noncoding material is either inserted or one Charles Darwin made a century and a mind, Science has decided to put Darwin in deleted in the chimp as compared to the half ago. By recognizing how natural selec- the spotlight by saluting several dramatic human, bringing the total difference in DNA tion shapes the diversity of life, he trans- discoveries, each of which reveals the laws between our two species to about 4%. formed how biologists view the world. But of evolution in action. Somewhere in this catalog of difference like all pivotal discoveries, Darwin’s was a lies the genetic blueprint for the traits that beginning. In the years since the 1859 publi- All in the family make us human: sparse body hair, upright cation of The Origin of Species, thousands One of the most dramatic results came in gait, the big and creative brain. We’re a long of researchers have September, when an international team pub- way from pinpointing the genetic underpin- BREAKTHROUGH sketched life’s transi- lished the genome of our closest relative, the nings of such traits, but researchers are ONLINE tions and explored chimpanzee. With the human genome already zeroing in on a few genes that may For an expanded aspects of evolution already in hand, researchers could begin to affect brain and behavior.
    [Show full text]
  • Refueling the Magic Furnace: Kilonova 2017 Rewrites the Story of Element Origins
    Refueling the Magic Furnace: Kilonova 2017 Rewrites the Story of Element Origins Barry Wood University of Houston Abstract For more than half a century, we have understood element creation in the stars—described in Marcus Chown’s colorful image as “the magic furnace.” From 1958 until 2017, supernova explosions were thought to be the primary site of element creation above Iron, No. 26 on the Periodic Table. This assumption was radically overturned with the August 17, 2017, arrival of signals from a catastrophic collision of neutron stars. This paper traces the history of element-creation science leading to the striking discoveries attending “Kilonova 2017” that now call for a rewriting of the nucleosynthesis chapter of Big History. Correspondence | Barry Wood, [email protected] Citation | Wood, B. (2018) Refueling the Magic Furnace: Kilonova 2017 Rewrites the Story of Element Origins. Journal of Big History, II(3); 1 - 15. DOI | http://dx.doi.org/10.22339/jbh.v2i3.2300 Introduction Beginning at 24 Hertz, it gradually rose over 100 Pangea had recently broken up . North America and seconds to several hundred Hertz—indicating the Europe were slowly drifting apart inspiraling of two massive bodies about to detonate . the Himalayas had not yet appeared . tropical in a cataclysmic collision. Following 3,000 cycles, the jungles harbored enormous predatory dinosaurs that GW signal came to an abrupt end at 12:41:04.4 UTC would roam the earth for another 65 million years . (Coordinated Universal Time). Almost immediately mammals the size of housecats kept to the shadows . (1.74 seconds later) a two-second gamma-ray burst .
    [Show full text]
  • Curriculum Vitae Feryal Ozel¨
    CURRICULUM VITAE FERYAL OZEL¨ University of Arizona Phone: 1-520-621-7096 Department of Astronomy Fax: 1-520-621-1532 933 N. Cherry Ave. E-mail: [email protected] Tucson, AZ 85721, U.S.A. http://xtreme.as.arizona.edu/~fozel RESEARCH INTERESTS Theoretical, Computational, Nuclear, Plasma, and High Energy Astrophysics, Black Holes, Neutron Stars, High Performance Computing EDUCATION Ph. D. in Physics, Harvard University 2002 Thesis Title: The Effects of Strong Magnetic and Gravitational Fields on Neutron Star Atmospheres, Advisor: Ramesh Narayan M. S. in Particle Physics, Niels Bohr Institute, Denmark 1997 Thesis Title: Search for the Supersymmetric Decays of the Higgs Boson at ALEPH B. S. in Applied Physics and Mathematics, Columbia University 1996 Summa cum Laude, Tau Beta Pi Honor Society POSITIONS Member, University of Arizona Applied Research Corporation 2020 { present Professor, University of Arizona 2015 { Present Associate Professor, University of Arizona 2009 { 2014 Assistant Professor, University of Arizona 2005 { 2009 Hubble Fellow, Member, Institute for Advanced Study 2002 { 2004 VISITING POSITIONS Visiting Professor, Member, Harvard University Black Hole Initiative 2016 { 2017 Visiting Miller Professor, University of California Berkeley 2014 Radcliffe Institute for Advanced Study Fellow, Harvard University 2012 { 2013 SELECTED DISTINCTIONS AND AWARDS Breakthrough Prize 2020 American Astronomical Society Bruno Rossi Prize 2020 Named Breakthrough of the Year by Science 2020 NSF Diamond Achievement Award 2019 Outstanding Achievement Award, METU 2019 Joined JASON, Advisory group to the U.S. government on science and technology 2017 Columbia University Annual Bishop Lecturer 2017 Guggenheim Fellow 2016 Elected Fellow of the American Physical Society 2015 U.C. Berkeley Miller Visiting Professorship 2014 American Physical Society Maria Goeppert Mayer Award 2013 Elected to Science Academy, Turkey 2013 Harvard University Radcliffe Institute Fellowship 2012 { 2013 San Diego Astronomy Association Lucas Award 2010 Bart J.
    [Show full text]
  • From Ardipithecus Ramidus to Homo Sapiens
    36 Duke of Edinburgh Prize to: Gen Suwa Professor and Director, The University Museum, The University of Tokyo for “Human Origins and Evolution: from Ardipithecus ramidus to Homo sapiens” Outline of the work: Prof. Gen Suwa is a biological anthropologist and paleoanthropologist who has considerably contributed to the understanding of human evolution through the discovery and analysis of fossil human remains and associated contextual evidence. His most notable contribution is the elucidation of the earliest stages of human ancestry via the discovery and analysis of the 4.4 million-year (Ma)-old Ardipithecus ramidus and the nearly 6-Ma-old but more fragmentary Ardipithecus kadabba fossils. Other major works include the discovery and naming of the 8-Ma-old African great ape Chororapithecus abyssinicus, the establishment of the timing of the split between the Homo and the robust Australopithecus lineages, the dating of the earliest Acheulean stone tools to 1.75 Ma, and various studies on more recent Pleistocene and Holocene fossil and skeletal materials. Between the 1980s and 1990s, Prof. Suwa has led the comparative analysis of Australopithecus and early Homo, particularly regarding dental fossil records spanning a period between 4 and 1 Ma. Importantly, his work is internationally recognized as the standard for the period between 3 and 2 Ma, which is crucial for the understanding of the emergence of the genus Homo and its subsequent evolutionary trajectories. Suwa’s work on the dentition contributed significantly to the elucidation of the evolution of the earliest Australopithecus species from the more primitive Ardipithecus ramidus by 4.2 Ma, which then largely evolved as a lineage with considerable populational variation and finally split into two clades just after 3 Ma.
    [Show full text]
  • Charles D. Kilpatrick
    Charles D. Kilpatrick Contact University of California, Santa Cruz Voice: (831) 459-5098 Information Department of Astronomy & Astrophysics E-mail: [email protected] 1156 High Street www: https://people.ucsc.edu/~cdkilpat Santa Cruz, CA 95064 Office: ISB 363 Research gravitational wave astronomy, supernovae, supernova remnants, transient astronomy Interests Academic Postdoctoral Scholar, University of California, Santa Cruz 2016{Present Appointments Advisor: Ryan J. Foley Education Ph.D., Astronomy, University of Arizona 2016 \New Observational Insight on Shock Interactions Toward Supernovae and Supernova Remnants" Advisor: George H. Rieke B.Sc., Astrophysics & History (Minor), California Institute of Technology 2010 Previous Summer Undergraduate Research Fellowship 2009 Research Division of Physics, Math, & Astronomy, Caltech Experience Advisor: Lynne Hillenbrand Topic: Modeling Enhanced Metallicity in the Atmospheres of Planet-Host Stars Physical Science Technician 2008 Smithsonian Astrophysical Observatory Advisor: Brian McLeod Topic: Calibrating the MMT & Magellan Infrared Spectrograph Summer Research Fellowship 2007 Department of Physics & Astronomy, UNC Chapel Hill Advisor: J. Christopher Clemens Topic: Modeling and Testing the Throughput of Volume Phase Holographic Gratings Honors and UC Santa Cruz Barbara Walker \Best Paper" Award 2018 Awards AAS Rodger Doxsey Travel Prize 2016 Caltech, graduated with Honors in Astrophysics & History 2010 Observing Ongoing Programs as Principal Investigator Programs Nickel 1m/APF 2.4m (2016Q4{present)
    [Show full text]
  • The Road from Genomics to Personalized Medicine
    The road from genomics to personalized medicine Raeka Aiyar EMBL [email protected] Steinmetz Group Genome Biology Unit EMBL Heidelberg EUSJA Visit, 18 July 2011 www.embl.de/research/units/genome_biology/steinmetz 6 billion base pairs, 22K protein-coding genes, ~300K proteins ~6 million diferences between two individuals Understanding Understanding Understanding Advancing Improving the the structure of the biology of the biology of the science of effectiveness of genomes genomes disease medicine healthcare 1990-2003 Human Genome Project 2004-2010 2011-2020 Beyond 2020 Green, ED et al. Charting a course for genomic medicine from base pairs to bedside. Nature (2011) Personalized/P4 Medicine • Predictive - development of probabilistic health projection based on individual DNA and gene expression • Preventative - creation of therapeutics that will prevent a disease a person is at risk of developing • Personalized - treating an individual based on their unique human genetic variation, complementing the predictive and preventative efforts above • Participatory - patient's active, informed involvement in their medical choices and care, acting in partnership with their health providers The success of genomics Genomic achievements since the Human Genome Project Southern African genome sequences First personal genome Rhesus macaque NCBI's Database of Genotypes and sequenced using new technologies genome sequence Completion of the Mammalian Phenotypes (dbGaP) launched Gene Collection (MGC) 500th genome-wide 9 10 11 12 Phase I HapMap 3 6 7 8 association
    [Show full text]
  • Science Breakthroughs
    EDITORIAL Science Breakthroughs AS ANNOUNCED IN THIS ISSUE, SCIENCE’S CHOICE FOR BREAKTHROUGH OF THE YEAR FOR 2011 Bruce Alberts is Editor- is based on the paper Prevention of HIV-1 Infection with Early Antiretroviral Therapy* (see in-Chief of Science. p. 1628). This provocative choice was made after much deliberation involving our News and Editorial staff, plus our Board of Reviewing Editors. The study involved more than 1700 heterosexual couples, of whom one partner was infected with the human immunodefi ciency virus (HIV) and the other was not at the start of the trial. All those infected still had relatively intact immune systems. The study gave antiretroviral drugs to half of the infected people and delayed giving treatment to the other half until their immune systems declined to a dangerous degree. The results of this early treatment with a cocktail of antiviral drugs were dramatic, lowering the rate at which the HIV-free partner became infected 20-fold, while also improv- ing outcomes for the infected partner. In combination with other promising clinical trials, the results have galvanized efforts to end the world’s AIDS epidemic in a way that would have been inconceivable even a year ago. “The goal of an AIDS-free generation is ambitious, but it is possible,” U.S. Secretary of State Hillary Clinton told scientists last month. This is not to say that we can abandon the search for an AIDS vaccine. Nor will profound change come overnight from the prom- on January 3, 2012 ise of using treatment as prevention. But for its role in making suc- cess conceivable, we have chosen the results of this trial as our Breakthrough of the Year.
    [Show full text]