Neonatal hand, foot, and mouth disease due to Coxsackievirus A6 in Shanghai Shanshan Xu Shanghai Jiaotong University School of Medicine Xinhua Hospital Huajun Li Shanghai Jiaotong University School of Medicine Xinhua Hospital Peng Qiao Shanghai Yangpu District Center for Disease Control and Prevention Guofeng Xu Shanghai Jiaotong University School of Medicine Xinhua Hospital Dongying Zhao Shanghai Jiaotong University School of Medicine Xinhua Hospital Xiaoyan Lin Shanghai Jiaotong University School of Medicine Xinhua Hospital Yu Qin Xingtai People's Hospital Huiju Yu Shanghai Jiaotong University School of Medicine Xinhua Hospital Xi Zhang Shanghai Jiaotong University School of Medicine Xinhua Hospital Wanju Zhang Shanghai Public Health Clinical Center Lisu Huang (
[email protected] ) https://orcid.org/0000-0001-8193-7353 Research article Keywords: Hand-foot-and-mouth disease, Neonate, Coxsackievirus A6, Clinical symptom, Transmission route, Immunologic function Posted Date: January 2nd, 2020 DOI: https://doi.org/10.21203/rs.2.14800/v3 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/15 Version of Record: A version of this preprint was published on August 3rd, 2020. See the published version at https://doi.org/10.1186/s12887-020-02262-y. Page 2/15 Abstract Background: Evidence of hand, foot, and mouth disease (HFMD) in neonates is limited. The aim of this study was to evaluate the clinical symptoms, possible transmission routes, and prognosis of neonatal HFMD in Shanghai. Methods: This was a case-control study based on the HFMD registry surveillance system. All neonates and infected family members were enrolled between 2016 and 2017 in Shanghai.