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Addiction Treatment Company …With Enormous Future Potential

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Addiction Treatment Company …With Enormous Future Potential A World Leading Addiction Treatment Company …with enormous future potential Jefferies Healthcare Conference 2014 Disclaimer . For the purposes of this disclaimer the "Presentation" shall mean and include these slides, the oral presentation of the slides, any document that follows, any oral briefing, the question and answer session that follows the oral briefing, and any material distributed at, or in connection with, the presentation. By attending or reading the Presentation, you will be deemed to have agreed to the obligations and restrictions set out below. The Presentation is strictly private and confidential and is intended solely for the information of analysts and/or investors in connection with the proposed demerger by Reckitt Benckiser Group plc of its pharmaceutical business (the “Demerger”). It is not an offer or invitation to the public and should not be reproduced or circulated or used for any purpose other than assisting with the assessment of the Demerger. It should not be shared with or disclosed to any third party without the prior written permission of Reckitt Benckiser Group plc or Indivior PLC. Under no circumstances may any person contact the management or employees of Reckitt Benckiser Group plc or Indivior PLC, or its shareholders, or visit any sites used by the Reckitt Benckiser Group plc or Indivior PLC. The Presentation is not a prospectus. It does not constitute an offer of securities for sale or a solicitation of an offer to purchase securities in any jurisdiction. The shares of Indivior PLC have not been, and will not be, registered under the US Securities Act of 1933, and may not be offered or sold within the United States, except pursuant to an applicable exemption from, or in a transaction not subject to, the registration requirements of the US Securities Act of 1933 and in compliance with any applicable securities laws of any state or other jurisdiction of the US. There will be no public offering of the Indivior PLC shares in the US for the purposes of the US Securities Act of 1933. No representations or warranties, express or implied are given in, or in respect of, the Presentation or any further information supplied. In no circumstances, to the fullest extent permitted by law, will Reckitt Benckiser Group plc, Indivior PLC, or any of their respective subsidiaries, shareholders, affiliates, representatives, partners, directors, officers, employees, advisers or agents, or any other person be responsible or liable for any direct, indirect or consequential loss or loss of profit arising from the use of the Presentation, its contents (including the management presentations and details on the market), its omissions, reliance on the information contained herein, or on opinions communicated in relation thereto or otherwise arising in connection therewith. The Presentation is supplied as a guide only and does not purport to contain all the information that you may require. The Presentation is exempt from the general restriction (in section 21 of the Financial Services and Markets Act 2000) on the communication of invitations and inducements to engage in investment activity on the grounds that this presentation is being directed only at (a) persons outside the United Kingdom, (b) persons who have professional experience in matters relating to investments who fall within Article 19 of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005 (the “Order”) or (c) high net worth companies and other persons to whom it may be lawfully communicated, falling within Article 49 of the Order or otherwise. The information contained in the Presentation does not, and will not, form any part of a contract or offer for sale. The Presentation may contain forward-looking statements that are based on current expectations or beliefs, as well as assumptions about future events. Although we believe our expectations, beliefs and assumptions are reasonable, reliance should not be placed on any such statements because, by their very nature, they are subject to known and unknown risks and uncertainties and can be affected by other factors that could cause actual results, and our plans and objectives, to differ materially from those expressed or implied in the forward-looking statements. You are cautioned not to place undue reliance on any forward-looking statements, which speak only as of the date hereof. Neither Reckitt Benckiser Group plc nor Indivior PLC nor any other person undertakes any obligation to revise or update any forward-looking statement contained within this presentation, regardless of whether those statements are affected as a result of new information, further events or otherwise. Past performance is not an indicator of future performance. The Presentation, including this disclaimer, shall be governed by and construed in accordance with English law and any claims or disputes, whether contractual or non-contractual, arising out of, or in connection with, the Presentation, including this disclaimer, shall be subject to the exclusive jurisdiction of the English Courts. Indivior PLC is the industry leader in treatment of addiction Global Leader in Opioid Addiction Treatment Several Levers for Future Growth • Structurally growing market • Pipeline & business development • Unrivalled experience and reputation • Global expansion Sustainable franchise with existing products Strong, experience, stable management team • Multi-layered IP protection to 2030 • Excellent track record • Specialty pharmaceutical company focused on developing and commercialising products for the addiction and closely related markets • Product portfolio includes Suboxone Film, Suboxone Tablets and Subutex • Key product today is Suboxone Film (buprenorphine + naloxone) for treatment of Opioid Dependency • Pipeline of lifecycle management and new drug candidates in addiction and CNS • Presence in 45 countries globally • $1,216m net revenue and $489m net income in 2013 • Led by experienced management team with decades of experience in addiction …with an exciting pipeline of new opportunities Stages of development and earliest approval dates* Stage of Development Estimated Approval Dates Phase I Phase II Phase III NDA 2014 2015 2016 2017 2018 2019 2020 Lifecycle management USA LAUNCHED Can Suboxone film EU China Depot EU Swallowable tablet Other areas of addiction Nasal Naloxone Cocaine Overdose Arbaclofen Placarbil Immediate Adjacencies Risperidone * Dates are best estimates only and could be subject to change OUR VISION That all patients around the world will have unrestricted access to high quality treatment services for the chronic relapsing conditions and co-morbidities of addiction In support of this, we will leverage our unique patient focused leadership model The four stages of treatment development Drug Policy & Regulatory Environment 01 02 03 04 Illegal Harm Reduction Recognised Disease Legitimised Disease Illegal drug Criminal Stigmatised patient Patient in treatment Patient user client Broad access Prevented from providing Distribution of by legislation Focus on quality care with Mix of supervised dosing treatment or very tightly pharmaceuticals through psycho-social support. Physician or regulation and take-homes controlled “drug clinics” Take-home standard Driven by Government funded clinics trying to Funding often limited or Insured patients in Payor reduce crime and needle capped by Governments mainstream medicine sharing Heroin Heroin & Prescription Opioids Realizing our vision 01 Attract and retain a highly dedicated team of people who are passionate about helping addicted patients 02 Have addiction recognized as a chronic relapsing disease among public health care officials, managed care and doctors 03 Train physicians, with the help of medical opinion leaders, how to provide high quality care including psychological support services 04 Build patient awareness of treatment availability and make treatment easily accessible to patients 05 Develop products with the aim of improving patient compliance Source: RBP investor & analyst presentation – July 2011 Outstanding success in developing the market We grew the market …Supported by a consistent growth in 5mm+ patients have received beyond expectations certified physicians treatment through Suboxone therapy US market size by mg (tablets & film)… 2,500 30,000 5mm 27,536 25,581 2,000 25,000 23,018 4mm 20,695 20,000 18,454 1,500 16,105 3mm 15,000 12,585 Millions 1,000 2mm 10,000 9,359 6,154 Cumulative patients treated Certified physicians by year 500 1mm 5,000 3,682 0 0mm 0 2007 2008 2009 2010 2004 2005 2006 2011 2012 2013 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 Nov-04 Nov-05 Nov-06 Nov-07 Nov-08 Nov-09 Nov-10 Nov-11 Nov-12 May-05 May-06 May-07 May-08 May-09 May-10 May-11 May-12 May-13 Source: Source Healthcare Analytics Retail and Non-Retail Sales data; Source: Healthcare Analytics Retail Sales Data; internal modelling; NTIS DEA Certification List Internal modeling October 2014 Rewarded by consistent revenue and profit delivery 1600 Net Revenue ($m) 1000Operating Profit ($m) 900 1400 872 884 800 1339 824 1200 1254 1216 700 1152 695 1000 600 650 934 500 800 400 600 398 628 300 400 426 200 242 200 100 0 0 2007 2008 2009 2010 2011 2012 2013 2007 2008 2009 RBP2010 R&D2011 expenditure:2012 2013 2012 $41m 2013 $76m The future: 5 value drivers Sustainability versus current Pipeline Inorganic competition opportunities Sustainability Opportunities versus future to grow the competition market Business update 2 Years Ago Today • Film share 55% • Film
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