Chapter XII Infection of Skin

Total Page:16

File Type:pdf, Size:1020Kb

Chapter XII Infection of Skin Infection of Skin Cellulitis Chapter XII Necrotizing fasciitis Wound infection Epidermis L00-L99 Skin and Dermatitis Ulcer Subcutaneous Tissue Dermis Gangrene Erysipelas นพ.บรรกษ เจรญศลป พญ.รงใจ เจรญศลป Hypodermis Pressure sore Cellulitis กลมงานศลยกรรม แพทยโสต ศอ นาสก รพ.สวรรคประชารกษ รพ.ปรนซปากนโพ Lymphadenopathy Fascia นครสวรรค นครสวรรค Necrotizing fasciitis Muscle Myositis 1 2 Tabular List & Alphabetical Index Skin & Soft Tissue Infection Skin & Soft Tissue Infection Clinical Practice vs ICD-10 Aetiology >> Lesion > Site Summary Diagnosis ICD-10 Summary Diagnosis ICD-10 ลดบการบนทกวนจฉย Erysipelas A46 Abscess ‣ บนทกการวนจฉยรอยโรคทรนแรงสด หรอเนอเยอชนลกสด Cellulitis at eyelid [hordeolum] H00.0 following immunization T88.0 at nose, nasal septum J34.0 ระบตแหนงทางกายวภาคของรอยโรค หรอชนดเนอเยอเฉพาะ ‣ at drainage site T81.4 at auricle, external auditory canal H60.0 ‣ ระบสาเหตของการอกเสบตดเชอ at auricle/external auditory canal H60.1 at preauricular sinus Q18.1 at penis N48.2 at other sites [defined anatomical site, include L02.- ‣ ระบเชอกอโรค ๏ Epidermis: Erysipelas, Impetigo, Folliculitis, Ectyma, Carbuncle at other sites [defined anatomical site] L03.- folliculitis, furuncle, carbuncle] Lymphangitis I89.1 Breast abscess N61 Dermis: Cellulitis, Abscess ๏ Gas gangrene A48.0 Breast abscess in puerperium O91.0 Postpartum breast abscess O91.0 ๏ Subcutaneous fat: Necrotizing fasciitis Clostridial cellulitis A48.0 Anorectal abscess [perianal, intersphincteric, K61.- Necrotizing fasciitis [defined anatomical site] M72.6- ๏ Muscle: Pyomyositis ischiorectal] Pilonidal abscess L05.0 3 4 Tabular List & Alphabetical Index Wound / Ulcer / Gangrene Tabular List & Alphabetical Index Skin & Soft Tissue Infection Ambiguous Diagnosis in Clinical practice Aetiology >> Lesion > Site T79.3 Post-traumatic wound infection, not elsewhere classified Use additional code (B95-B97), if desired, to identify infectious agent Summary Diagnosis ICD-10 การบนทกวนจฉย ใหพจารณาสาเหตของการเกดแผล T81.4 Infection following a procedure, not elsewhere classified Bartholin’s abscess N75.1 ‣ เกดทแผลผาตด [surgical wound] Abscess: Bartholin’s abscess in pregnancy O23.5 • postprocedural intra-abdominal Bartholin’s abscess in puerperium O86.1 ‣ เปนแผลกดทบ [pressure sore, decubitus ulcer] • postprocedural stitch Abscess at surgical wound T81.0 • postprocedural subphrenic Stitch abscess T81.0 ‣ เกดจากการบาดเจบ [post-traumatic wound] • postprocedural wound Hiadradenitis suppurativa L73.2 ‣ ภาวะแทรกซอนจากโรคระบบอน [vascular, diabetes] Sepsis Sebaceous cyst abscess L73.2 T87.4 Infection of amputation stump เปนแผลไฟไหม นรอนลวก [burns] Epidermal inclusion cyst abscess L72.0 ‣ T87.5 Necrosis of amputation stump T87.6 Other and unspecified complications of amputation stump Amputation stump: • contracture (flexion)(of next proximal joint) • haematoma • oedema 5 6 Wound / Ulcer / Gangrene Tabular List & Alphabetical Index Wound / Ulcer / Gangrene Tabular List & Alphabetical Index Ambiguous Diagnosis in Clinical practice Ambiguous Diagnosis in Clinical practice L98.4 Chronic ulcer of skin, not elsewhere classified I83.0 Varicose vein of lower extremities with ulcer Chronic ulcer of skin NOS Any condition in I83.9 with ulcer or specified as ulcerated Tropical ulcer NOS Varicose ulcer (lower extremity, any part) Ulcer of skin NOS I83.1 Varicose vein of lower extremities with inflammation Excludes: decubitus [pressure] ulcer and pressure area ( L89.- ) Any condition in I83.9 with inflammation or specified as inflamed gangrene ( R02 ) Stasis dermatitis NOS skin infections ( L00-L08 ) I83.2 Varicose vein of lower extremities with both ulcer and inflammation specific infectious classified to A00-B99 Any condition in I83.9 with both ulcer and inflammation ulcer of lower limb NEC ( L97 ) varicose ulcer ( I83.0-I83.2 ) L89 Decubitus ulcer and pressure area L97 Ulcer of lower limb, not elsewhere classified Note: For multiple sites of differing stages assign only one code indicating the highest stage. Excludes: decubitus [pressure] ulcer and pressure area ( L89.- ) Includes: bedsore gangrene ( R02 ) plaster ulcer skin infections ( L00-L08 ) specific infectious classified to A00-B99 varicose ulcer ( I83.0-I83.2 ) 7 8 Wound / Ulcer / Gangrene Tabular List & Alphabetical Index Wound / Ulcer / Gangrene Tabular List & Alphabetical Index Ambiguous Diagnosis in Clinical practice Ambiguous Diagnosis in Clinical practice I70 Atherosclerosis R20 Gangrene, not elsewhere classified Includes: arteriolosclerosis Excludes: gangrene in: arteriosclerosis • atherosclerosis ( I70.2 ) arteriosclerotic vascular disease • diabetes mellitus ( E10-E14 with common fourth character .5 ) atheroma • other peripheral vascular disease ( I73.- ) degeneration: I70.2 Atherosclerosis of arteries of extremities gangrene of certain specified sites - see Alphabetical Index • arterial Atherosclerotic gangrene gas gangrene ( A48.0 ) • arteriovascular Monckeberg’s (medial) sclerosis pyoderma gangrenosum ( L88 ) • vascular endarteritis deformans or obliterans senile: • arteritis • end arteritis The following supplementary classification to indicate the presence or absence of gangrene is provided for optional use with appropriate subcategories in I70 0 without gangrene 1 with gangrene 9 10 Tabular List & Alphabetical Index Skin & Soft Tissue Infection Necrotizing Fasciitis Aetiology >> Lesion > Site Excisional Debridement Summary Diagnosis ICD-10 Summary Diagnosis ICD-10 Infected wound Infected wound Surgical wound [general] T81.4 Surgical wound [general] T81.4 Surgical wound [orthopedics implant] T85.7 Surgical wound [orthopedics implant] T85.7 Amputated stump T87.4 Amputated stump T87.4 Pressure sore [at least on stage 3] L89.- Pressure sore [at least on stage 3] L89.- Traumatic wound ** T79.3 Traumatic wound ** T79.3 Ulcer Arterial ulcer I70.20 Venous ulcer I83.0 Venous ulcer and inflammation I83.2 Unknown caused: at lower limb L97 other site L98.4 11 12 ผปวยถกเปลอกหอยเชอรบาดขาซายขณะจบปลาในบงไปขาย ผปวยถกเปลอกหอยเชอรบาดขาซายขณะจบปลาในบงไปขาย Necrotizing Fasciitis 4 วนตอมา บวมแดงทงขา มตมนสแดงคล กดเจบ นผปวย 4 วนตอมา บวมแดงทงขา มกดเจบ ใหการรกษาดวย cefazolin Label site of infection เขาหองผาตด รายงานผาตดพบ necrosis of skin with cloudy เปนเวลา 5 วน อาการดขน จหนายในวนท 6 สถานภาพ fluid in subfascial plane ไดตดเลาะผวหนงทเนาตายออก จหนายดขน เกณฑการวนจฉย สปสช. 2562 ขนาด 8x10 เซนตเมตร ‣ มลกษณะรอยโรคทเขาไดกบโรค PDx Necrotizing fasciitis at left leg M72.66 PDx Cellulitis at left leg L03.1 • บวมแดง ปวด ถาไมครบเกณฑการวนจฉย Op Excisional debridement 86.22 Op • ตมพองนสแดง [haemorrhagic bleb] ใหสรปการวนจฉยเปน Cellulitis • ผวหนงมเนอตาย [necrotic skin] EC หอยเชอรบาดขณะจบปลาไปขาย W49.82 EC หอยเชอรบาดขณะจบปลาไปขาย W49.82 ‣ อาจตรวจพบนขงใตชนพงผด [subfascial fluid] M72.66 Necrotizing fasciitis at leg L03.1 Cellulitis of other parts of limb ‣ มการรกษาดวยวธ excisional debridement หรอ refer หรอ dead W49.82 Exposure to other and unspecified inanimate at W49.82 Exposure to other and unspecified inanimate at M72.6- lake while working for income lake while working for income 86.22 Excisional debridement of wound, infection, or burn DRG 08310 RW 1.8671 [N w ED] DRG 09560 RW 0.6930 [C] DRG 09050 RW 1.9848 [C w ED] DRG 08611 RW 0.9788 [N] 13 14 Tabular List & Alphabetical Index ผปวย old CVA มาดวยแผลเรอรงทกนกบ มหนองไหลกลน ผปวยอมพาตครงซกซาย มาดวยแผลเรอรงทกนกบ มหนอง Pressure Sore / Decubitus Ulcer เหมน นานกวา 2 เดอน ตรวจพบแผลลกถงกระดก แพทย ไหลกลนเหมน นานกวา 2 เดอน ตรวจพบแผลลกถงกระดก Label staging วนจฉยวา chronic osteomyelitis แพทยวนจฉยวา pressure sore stage 4 ‣ ระบความลกของแผลของแผลทรนแรงทสด L89.0-L89.3 • ระยะท 1 รอยแดงทกดไมจางลง รอยชใน ผวสคล PDx Chronic osteomyelitis at sacrum M86.65 PDx Decubitus ulcer stage IV L89.3 • 2 ระยะท ถลอก ตมพอง Old CVA Z86.7 Sequelae of CVA I69.4 SDx SDx • ระยะท 3 ผวหนงตาย หลดลอก Flaccid left hemiplegia G81.0 • ระยะท 4 ลกถงกลามเนอ เอน ปลอกหมขอ ขอ กระดก EC EC กรณมผลเพาะเชอของแผล ใหระบเชอกอโรคเปนการวนจฉยรอง ‣ M86.65 Other chronic osteomyelitis at buttock L89.3 Decubitus ulcer and pressure area stage IV Z86.7 Personal history of diseases of the circulatory I69.4 Sequelae of stroke, not specified as haemorrhage or system infarction Infected pressure sore = Pressure sore Condition classifiable to I00-I99 G81.0 Flaccid hemiplegia DRG 08530 RW 1.3653 DRG 09500 RW 1.4164 DRG 08311 RW 4.4277 [D] DRG 09050 RW 1.9848 [D] 15 16 Tabular List & Alphabetical Index Lymphatic Disorders Lymphatic & Venous Disorders Aetiology >> Lesion > Site Summary Diagnosis ICD-10 Summary Diagnosis ICD-10 Lymphadenitis ๏ Lymphangitis I89.1 Phlebitis I80.9 Acute lymphangitis L03.- ๏ Lymphangitis Phlebitis of upper extremity I80.8 Chronic lymphangitis I89.1 Phlebitis of lower extremity I80.3 ๏ Lymphadenopathy Lymphadenitis O91.2 Superficial phlebitis of lower extremity I80.0 Acute lymphadenitis L04.- Phlebitis of femoral vein I80.1 Chronic lymphadenitis I88.1 Deep vein thrombosis I80.2 Mesenteric lymphadenitis I88.0 Deep vein thrombosis of femoral vein I80.1 Tuberculous lymphadenitis A18.2 Mesenteric tuberculous lymphadenitis A18.3 + K93.0 17 18 Lymphadenopahty Tabular List & Alphabetical Index Lymphadenopathy Palpable node in ICD-10 Ambiguous Diagnosis in Clinical practice R59 Enlarged lymph nodes Includes: swollen glands Excludes: lymphadenitis: ✦ Lymphadenopathy คอ ตอมนเหลองขนาดโตกวา 1 เซนตเมตร • NOS ( I88.9 ) เปนเวลานานกวา 2 สปดาห [epitrochear >0.5 cm, inguinal >1.5 cm] • acute ( L04.- ) • chronic ( I88.1 ) ๏ Generalised lymphadenopathy • mesenteric (acute)(chronic) ( I88.0 ) R59.0 Localized enlarged lymph node : ตอมนเหลองโตในบรเวณตางกน ตงแตสองตแหนงขนไป R59.1 Generalized
Recommended publications
  • WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/05 (2006.01) A61P 31/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/CA20 14/000 174 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 4 March 2014 (04.03.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 13/790,91 1 8 March 2013 (08.03.2013) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: LABORATOIRE M2 [CA/CA]; 4005-A, rue kind of regional protection available): ARIPO (BW, GH, de la Garlock, Sherbrooke, Quebec J1L 1W9 (CA). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: LEMIRE, Gaetan; 6505, rue de la fougere, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Sherbrooke, Quebec JIN 3W3 (CA).
    [Show full text]
  • Tropical Ulcer
    University of Nebraska Medical Center DigitalCommons@UNMC MD Theses Special Collections 5-1-1939 Tropical ulcer Mary K. Smith University of Nebraska Medical Center This manuscript is historical in nature and may not reflect current medical research and practice. Search PubMed for current research. Follow this and additional works at: https://digitalcommons.unmc.edu/mdtheses Part of the Medical Education Commons Recommended Citation Smith, Mary K., "Tropical ulcer" (1939). MD Theses. 776. https://digitalcommons.unmc.edu/mdtheses/776 This Thesis is brought to you for free and open access by the Special Collections at DigitalCommons@UNMC. It has been accepted for inclusion in MD Theses by an authorized administrator of DigitalCommons@UNMC. For more information, please contact [email protected]. TROPICAL ULCER By Mary K. Smith Presented to: Univer·aity of Nebraska College of Medicine April 14, 1939. TROPICAL ULCER TABLE OF CONTENTS Introduction • • • • • • • • • • • • • • • • • • • • • • • • • • • l Symptomatology • • • • • • • • • • • • • • • • • • • • • • • • • 4 Etiology • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • 15 Pathological Histology • • • • • • • • • • • • • • • • • 39 Relation of Tropical Ulcer to Other Fuso-Spirochaetal Diseases ••••••••••••••••••••••••••••• 50 Diagnosis •.................. •·• ........ 55 Treatment • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • 56 Conclusions • • • • • • • • • • • • • • • • • • • • • • • • • • • • 69 Bibliography • • • • • • • • • • • • • • • • • • • • • •
    [Show full text]
  • The Diagnosis & Management of Skin & Soft Tissue Infection
    THE DIAGNOSIS & MANAGEMENT OF SKIN & SOFT TISSUE INFECTION 7th December 2020 7th December 2022 Version History Version Status Date Editor Description 1.0 Final 7th December 2020 Guidelines Team Version for Publication. Citation Suggested citation style: Ministry of Public Health Qatar. National Clinical Guideline: The Diagnosis and Management of Skin and Soft Tissue Infection (2020). Abbreviations The abbreviations used in this guideline are as follows: ART Antiretroviral Therapy BIT Burrow Ink Test CA-MRSA Community-Associated Methicillin-Resistant Staphylococcus aureus CT Computed Tomography EPSD Epidermal Parasitic Skin Diseases FGSI Fournier’s Gangrene Severity Index HIV Human Immunodeficiency Virus HrCLM Hookworm-Related Cutaneous Larva Migrans LRINEC Laboratory Risk Indicator for Necrotising Fasciitis MMR Measles-Mumps-Rubella MCV Molluscum Contagiosum Virus MMRV Measles-Mumps-Rubella-Varicella MRI Magnetic Resonance Imaging MRSA Methicillin-Resistant Staphylococcus aureus MSSA Methicillin-Sensitive Staphylococcus aureus NSAID Non-Steroidal Anti-Inflammatory Drug S. aureus Staphylococcus aureus S. pyogenes Streptococcus pyogenes SSTIs Skin and Soft-Tissue Infections VZV Varicella Zoster Virus The Diagnosis and Management of Skin and Soft Tissue Infection (Date of next revision: 7th December 2022) 2 Table of Contents 1 Information about this Guideline ........................................................................................................... 6 1.1 Objective and Purpose of the Guideline .......................................................................................
    [Show full text]
  • | Oa Tai Ei Rama Telut Literatur
    |OA TAI EI US009750245B2RAMA TELUT LITERATUR (12 ) United States Patent ( 10 ) Patent No. : US 9 ,750 ,245 B2 Lemire et al. ( 45 ) Date of Patent : Sep . 5 , 2017 ( 54 ) TOPICAL USE OF AN ANTIMICROBIAL 2003 /0225003 A1 * 12 / 2003 Ninkov . .. .. 514 / 23 FORMULATION 2009 /0258098 A 10 /2009 Rolling et al. 2009 /0269394 Al 10 /2009 Baker, Jr . et al . 2010 / 0034907 A1 * 2 / 2010 Daigle et al. 424 / 736 (71 ) Applicant : Laboratoire M2, Sherbrooke (CA ) 2010 /0137451 A1 * 6 / 2010 DeMarco et al. .. .. .. 514 / 705 2010 /0272818 Al 10 /2010 Franklin et al . (72 ) Inventors : Gaetan Lemire , Sherbrooke (CA ) ; 2011 / 0206790 AL 8 / 2011 Weiss Ulysse Desranleau Dandurand , 2011 /0223114 AL 9 / 2011 Chakrabortty et al . Sherbrooke (CA ) ; Sylvain Quessy , 2013 /0034618 A1 * 2 / 2013 Swenholt . .. .. 424 /665 Ste - Anne -de - Sorel (CA ) ; Ann Letellier , Massueville (CA ) FOREIGN PATENT DOCUMENTS ( 73 ) Assignee : LABORATOIRE M2, Sherbrooke, AU 2009235913 10 /2009 CA 2567333 12 / 2005 Quebec (CA ) EP 1178736 * 2 / 2004 A23K 1 / 16 WO WO0069277 11 /2000 ( * ) Notice : Subject to any disclaimer, the term of this WO WO 2009132343 10 / 2009 patent is extended or adjusted under 35 WO WO 2010010320 1 / 2010 U . S . C . 154 ( b ) by 37 days . (21 ) Appl. No. : 13 /790 ,911 OTHER PUBLICATIONS Definition of “ Subject ,” Oxford Dictionary - American English , (22 ) Filed : Mar. 8 , 2013 Accessed Dec . 6 , 2013 , pp . 1 - 2 . * Inouye et al , “ Combined Effect of Heat , Essential Oils and Salt on (65 ) Prior Publication Data the Fungicidal Activity against Trichophyton mentagrophytes in US 2014 /0256826 A1 Sep . 11, 2014 Foot Bath ,” Jpn .
    [Show full text]
  • The Aetiology and Pathogenesis of Tropical Ulcer
    The Aetiology and Pathogenesis of Tropical Ulcer Town Beverley Adriaans Tropical DermatologyCape Unit Department ofof Medical Microbiology London School of Hygiene and Tropical Medicine Keppel Str eet London WClE 7HT England University A Thesis presented for the M.D. degree in the University of Cape Town, South Africa, 1988 . The copyright of this thesis vests in the author. No quotation from it or information derived from it is to be published without full acknowledgementTown of the source. The thesis is to be used for private study or non- commercial research purposes only. Cape Published by the University ofof Cape Town (UCT) in terms of the non-exclusive license granted to UCT by the author. University ABSTRACT Tropical ulcer is a very specific form of cutaneous ulceration. It occurs worldwide in most tropical and a number of subtropical areas. The disease occurs mainly in older children and young adults with children under the age of 5 and adults over 45 years rarely being affected. Ulcers occur most commonly on the lower leg but may occur on the upper limb. Although most ulcers normally heal slowly over many weeks or months, some ulcers may recur. Recognised complications include squamous cell carcinoma, gangrene and osteitis, although these are rare. A number of authors have reported on the disease and suggested diet, trauma and infection as aetiological factors for this condition. This survey was thus conducted to assess as many of these factors as possible. The study took place in 5 tropical areas, namely Zambia, Gambia, southern India, Fiji and Papua New Guinea. Consultations took place at hospitals, rural clinics, health centres and villages.
    [Show full text]
  • The History of Syphilis in Uganda
    Bull. Org. mond. Santeh 1956, 15, 1041-1055 Bull. Wld Hith Org. THE HISTORY OF SYPHILIS IN UGANDA J. N. P. DAVIES, M.D., Ch.B., M.R.C.S., L.R.C.P. Professor of Pathology, Makerere College Medical School, Kampala, Uganda SYNOPSIS The circumstances of an alleged first outbreak of syphilis in Uganda in 1897 are examined and attention is drawn to certain features which render possible alternative explanations of the history of syphilis in that country. It is suggested that an endemic form of syphilis was an old disease of southern Uganda and that protective infantile inoculation was practised. The country came under the observation of European clinicians at a time when endemic syphilis was being replaced by true venereal syphilis. This process has now been completed, endemic syphilis has disappeared, and venereal syphilis is now widespread and a more serious problem than ever. This theory explains the observations of other writers and reconciles the apparent discrepancies between various reports. Until comparatively recent times the country now known as Uganda was cut off from the rest of the world. The Nile swamps to the north, the impenetrable Congo forest to the west, the mountains and the upland plateaux with the warrior Masai to the east, and the other immense difficul- ties of African travel, had protected the country from intrusion. In the southern lacustrine areas there had developed the remarkable indigenous kingdoms of Bunyoro and Buganda. These became conscious of the larger outside world about 1850, when a Baluch soldier from Zanzibar reached the court of the King of Buganda, the Kabaka Suna.
    [Show full text]
  • Tropical Ulcer in Natal
    830 S.A. MEDICAL JOURNAL . 3 October 1959 Modern topical applications are often much more effective poisoning unless liberally doused with neat antiseptics­ than calamine lotion or mercury ointment, especially when more potential candidates for the skin department. used in the right case, but they carry a far greater risk of Only dermatologists would suffer if a law were passed causing allergic contact dermatitis than the simpler remedies banning the use of sulphonamides, penicillin, antihista­ of the past. minics, local anaesthetics, and antiseptics as topical applica­ The era of allergic contact-dermatitis medicamentosa was tions. These are the commonest offenders, but there are heralded by the sulphonamides, which are still among the few medicaments used today which have not occasionally, most potent alleJ;"gens commonly used in medicine. Derma­ tologists had begun to fear them by the early 1940's and or frequently, been incriminated as causes of allergic contact were happy to abandon them with the arrival of the anti­ dermatitis or primary irritation of the skin. Even hydro­ biotics. Penicillin soon proved to be just as dangerous cortisone has, on rare occasions, caused sensitization. and has also been discarded as a topical application by Patients should be warned of the possibility of sensitization dermatologists, if by few others. The later antibiotics, and told to discontinue treatment if their symptoms seem streptomycin excepted, are much less liable to cause allergic to be aggravated by the application of any remedy. contact dermatitis. 'Diagnosis precedes treatment' is a maxim to be heeded Lotions and ointments containing antihistaminics, para­ by those treating skin diseases.
    [Show full text]
  • Management of Tropical Ulcer What Is a Tropical Ulcer?
    Disclaimer: Treatment of skin diseases, common in developing countries, is often based on the use of simple management schemes which are easy to apply and cheap. The protocols here were devised to provide examples of recognition and treatment schedules which meet these criteria. It is important to recognise that these are seldom supported by a strong evidence base as many of the treatments were devised and assessed many years ago. However we hope that they provide useful examples of treatment protocols that can be applied in different countries using medications that are commonly available. They are broadly based on the evidence presented in the Disease Control Priorities project (www.dcp2.org). Management of Tropical Ulcer What is a tropical ulcer? 1. The exact cause is thought to be a combined infection by Fusobacterium ulcerans (an anaerobic bacterium) and a spiral bacteria - plus other bacteria 2. Small skin wounds allow penetration of the organisms which may be present in mud or stagnant water and which are thought to release toxins that cause a necrotic reaction in dermal tissue and lead to skin break down Which population is at risk? 1. It is commoner in children and teenagers 2. In adults it appears that they occur more frequently in women than in men 3. Malnutrition and poor health do not seem to be risk factors in the initial development of a tropical ulcer. However nutritional and health status may have an impact on the progression of the condition. 4. Those who receive small traumatic wounds to lower limbs and are in contact with mud or contaminated water.
    [Show full text]
  • Differential Diagnosis of Skin Ulcers in a Mycobacterium Ulcerans Endemic Area: Datafroma Prospective Study in Cameroon
    Differential Diagnosis of Skin Ulcers ina Mycobacterium ulcerans Endemic Area: Data from a Prospective Study in Cameroon Laurence Toutous Trellu, Patrick Nkemenang, Geneviève Ehounou, Eric Comte, Paul Atangana, Junior Mboua, Barbara Rusch, Earnest Njih Tabah, Jean-François Etard, Yolanda Mueller To cite this version: Laurence Toutous Trellu, Patrick Nkemenang, Geneviève Ehounou, Eric Comte, Paul Atangana, et al.. Differential Diagnosis of Skin Ulcers in a Mycobacterium ulcerans Endemic Area: Datafroma Prospective Study in Cameroon. PLoS Neglected Tropical Diseases, Public Library of Science, 2016, 10 (4), pp.e0004385. 10.1371/journal.pntd.0004385. hal-02560729 HAL Id: hal-02560729 https://hal.archives-ouvertes.fr/hal-02560729 Submitted on 2 May 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution| 4.0 International License RESEARCH ARTICLE Differential Diagnosis of Skin Ulcers in a Mycobacterium ulcerans Endemic Area: Data from a Prospective Study in Cameroon Laurence Toutous Trellu1*, Patrick Nkemenang2,
    [Show full text]
  • Bacterial Infections Chapter 14
    Bacterial Infections Chapter 14 Infections Caused by Gram Positive Organisms. Michael Hohnadel, D.O. 10/7/03 1 •Staphylococcal Infections • General • 20% of adults are nasal carriers. • HIV infected are more frequent carriers. • Lesions are usually pustules, furuncles or erosions with honey colored crust. • Bullae, erythema, widespread desquamation possible. • Embolic phenomena with endocarditis: • Olser nodes • Janeway Lesions 2 Embolic Phenomena With Endocarditis • Osler nodes Janeway lesion 3 Superficial Pustular Folliculitis • Also known as Impetigo of Bockhart • Presentation: Superficial folliculitis with thin wall, fragile pustules at follicular orifices. – Develops in crops and heal in a few days. – Favored locations: • Extremities and scalp • Face (esp periorally) • Etiology: S. Aureus. 4 Sycosis Vulgaris (Sycosis Barbae) • Perifollicular, Chronic , pustular staph infection of the bearded region. • Presentation: Itch/burn followed by small, perifollicular pustules which rupture. New crops of pustules frequently appear esp after shaving. • Slow spread. • Distinguishing feature is upper lip location and persistence. – Tinea is lower. – Herpes short lived – Pseudofolliculitis Barbea ingrown hair and papules. 5 Sycosis Vulgaris 6 Sycosis Lupoides • Staph infection that through extension results in central hairless scar surrounded by pustules. Pyogenic folliculitis and perifolliculitis with deep extension into hair follicles often with edema. • Thought to resemble lupus vulgaris in appearance. • Etiology: S. Aureus 7 Treatment of Folliculitis • Cleansing with soap and water. • Bactroban (Mupirocin) • Burrows solution for acute inflammation. • Antibiotics: cephalosporin, penicillinase resistant PCN. 8 Furunculosis • Presentation: Perifollicular, round, tender abscess that ends in central suppuration. • Etiology: S. Aureus • Breaks in skin integrity is important. – Various systemic disorders may predispose. • Hospital epidemics of abx resistant staph may occur – Meticulous hand washing is essential.
    [Show full text]
  • Tomonidan Ithutuotte
    TOMONIDANUS010022425B2 ITHUTUOTTE (12 ) United States Patent (10 ) Patent No. : US 10 ,022 , 425 B2 Bancel et al. ( 45) Date of Patent : Jul. 17 , 2018 ( 54 ) ENGINEERED NUCLEIC ACIDS AND 4 , 399 ,216 A 8 / 1983 Axel et al. METHODS OF USE THEREOF 4 ,401 , 796 A 8 / 1983 Itakura 4 ,411 ,657 A 10 / 1983 Galindo 4 ,415 , 732 A 11/ 1983 Caruthers et al . @(71 ) Applicant : Moderna TX , Inc ., Cambridge , MA 4 ,458 , 066 A 7 / 1984 Caruthers et al. (US ) 4 , 474 , 569 A 10 / 1984 Newkirk 4 ,500 ,707 A 2 / 1985 Caruthers et al . @(72 ) Inventors : Stephane Bancel, Cambridge , MA 4 , 579 , 849 A 4 / 1986 MacCoss et al. 4 ,588 , 585 A 5 / 1986 Mark et al. (US ) ; Jason P . Schrum , Philadelphia , 4 ,668 , 777 A 5 / 1987 Caruthers et al . PA (US ) ; Alexander Aristarkhov , 4 , 737 ,462 A 4 / 1988 Mark et al . Chestnut Hill, MA (US ) 4 ,816 , 567 A 3 / 1989 Cabilly et al . 4 ,879 , 111 A 11 /1989 Chong ( 73 ) Assignee : ModernaTX , Inc. , Cambridge, MA 4 , 957 , 735 A 9 / 1990 Huang 4 , 959 , 314 A 9 / 1990 Mark et al. (US ) 4 ,973 ,679 A 11/ 1990 Caruthers et al. 5 ,012 ,818 A 5 / 1991 Joishy @( * ) Notice: Subject to any disclaimer, the term of this 5 ,017 ,691 A 5 / 1991 Lee et al. patent is extended or adjusted under 35 5 ,021 , 335 A 6 / 1991 Tecott et al. U . S . C . 154 (b ) by 0 days . 5 , 036 , 006 A 7 / 1991 Sanford et al . 5 , 047 ,524 A 9 / 1991 Andrus et al .
    [Show full text]
  • Buruli Ulcer Manuela Boleira 1 Omar Lupi 2 Linda Lehman 3 Kingsley Bampoe Asiedu 4 Ana Elisa Kiszewski 5
    281 EDUCAÇÃO MÉDICA CONTINUADA L Úlcera de Buruli * Buruli ulcer Manuela Boleira 1 Omar Lupi 2 Linda Lehman 3 Kingsley Bampoe Asiedu 4 Ana Elisa Kiszewski 5 Resumo: A úlcera de Buruli, uma doença infecciosa causada pela Mycobacterium ulcerans (M. ulcer- ans), é a terceira micobacteriose em ocorrência, após a hanseníase e a tuberculose. Essa micobacte- riose atípica tem sido relatada em mais de 30 países, principalmente, nos que têm climas tropicais e subtropicais, mas a sua epidemiologia permanece obscura. Recentemente, os primeiros casos autóc- tones do Brasil foram relatados, fazendo com que dermatologistas brasileiros estejam atentos a esse diagnóstico. O quadro clínico varia: nódulos, áreas de edema, placas, mas a manifestação mais típica é uma grande úlcera, que ocorre, em geral, nas pernas ou nos braços. Apesar do amplo conhecimen- to quanto ao seu quadro clínico em países endêmicos, nas outras áreas, esse diagnóstico pode passar despercebido. Assim, médicos devem ser orientados quanto à úlcera de Buruli, pois o diagnóstico pre- coce, o tratamento específico e a introdução de cuidados na prevenção de incapacidades são essenci- ais para uma boa evolução. Palavras-chave: Infecções atípicas por mycobacterium; Mycobacterium ulcerans; Organização Mundial de Saúde; Úlcera de Buruli Abstract: Buruli ulcer, an infectious disease caused by Mycobacterium ulcerans, is the third most preva- lent mycobacteriosis, after tuberculosis and leprosy. This atypical mycobacteriosis has been reported in over 30 countries, mainly those with tropical and subtropical climates, but its epidemiology remains unclear. The first autochthonous cases of infection in Brazil have recently been described, making this diagnosis important for Brazilian dermatologists. Clinical manifestations vary from nodules, areas of edema, and plaques, but the most typical presentation is a large ulcer, usually in the limbs.
    [Show full text]