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Forschungsbericht 2015/2016 2 Inhaltsverzeichnis FORSCHUNGSBERICHT 2015/2016 2 Inhaltsverzeichnis Vorwort ���������������������������������������������������������������������������������������������5 Priority Research Area Infections Leibniz Lungenzentrum - nomen est omen - �����������������������������������6 Bioanalytical Chemistry ������������������������������������������������������������������74 EvoLUNG �����������������������������������������������������������������������������������������10 Biophysics ����������������������������������������������������������������������������������������78 Postdocs - zwischen Baum und Borke? �������������������������������������������12 Cellular Microbiology ����������������������������������������������������������������������82 Clinical Infectious Diseases �������������������������������������������������������������86 Menschen / People Coinfection ��������������������������������������������������������������������������������������90 Sven Perner �������������������������������������������������������������������������������������16 Diagnostic Mycobacteriology (NRC) �����������������������������������������������94 Xinhua Yu & Gabriela Riemekasten ������������������������������������������������17 Immunobiophysics ��������������������������������������������������������������������������98 Katharina Kranzer ����������������������������������������������������������������������������18 Infection Immunology �������������������������������������������������������������������102 Katarzyna Duda �������������������������������������������������������������������������������19 Microbial Interface Biology �����������������������������������������������������������106 Molecular and Experimental Mycobacteriology ��������������������������110 Farewell Guntram Graßl ��������������������������������������������������������������������������������20 Medicine Ekkehard Vollmer ����������������������������������������������������������������������������21 BioMaterialBank Nord ������������������������������������������������������������������114 Center for Clinical Studies �������������������������������������������������������������116 Media-/ Press-Clips 2015 / 2016 ������������������������������������������������������22 Clinical and Experimental Pathology ��������������������������������������������120 Science and Technology in Society forum 2016 Kyoto, Japan �������23 Best of 2015 ������������������������������������������������������������������������������������24 Core Facility Best of 2016 ������������������������������������������������������������������������������������26 Fluorescence Cytometry ���������������������������������������������������������������124 Priority Research Area Asthma and Allergy Facts & Figures Asthma Exacerbation & Regulation �����������������������������������������������30 Funding �����������������������������������������������������������������������������������������128 Autoimmunity in the Lung ��������������������������������������������������������������34 Patents and Licenses ���������������������������������������������������������������������128 Biochemical Immunology ���������������������������������������������������������������38 Academic Degree / Professional Qualifications����������������������������128 Clinical and Molecular Allergology �������������������������������������������������42 Guest Scientists �����������������������������������������������������������������������������129 DZL-Junior Group of Allergobiochemistry ��������������������������������������46 Peer Reviewed Publications ����������������������������������������������������������129 Early Life Origins of Chronic Lung Disease��������������������������������������50 Conferences / Workshops �������������������������������������������������������������129 Experimental Pneumology ��������������������������������������������������������������54 Books and Articles in Books ����������������������������������������������������������129 Innate Immunity �����������������������������������������������������������������������������58 National Networks 2015/2016 �����������������������������������������������������129 Invertebrate Models �����������������������������������������������������������������������62 International Networks 2015/2016 ����������������������������������������������129 Mucosal Immunology and Diagnostics �������������������������������������������66 Structural Biochemistry ������������������������������������������������������������������70 Organization Chart ������������������������������������������������������������������������130 gefördert durch: 3 Wissenschaftlicher Beirat / Scientific Advisory Board Prof. Dr. Claus Vogelmeier (Vorsitzender) Klinik für Pneumologie Universitätsklinikum Gießen-Marburg, Marburg Prof. Dr. Axel Brakhage (stv. Vorsitzender) Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie (HKI), Jena Prof� Dr� Bernhard Fleischer Bernhard-Nocht-Institut für Tropenmedizin, Hamburg Prof. Dr. Sven Hammerschmidt Abtl. Genetik der Mikroorganismen Ernst-Moritz-Arndt-Universität, Greifswald Prof. Dr. Beate Kampmann Paediatric Infection & Immunity Imperial College / St Mary‘s Campus, London Prof� Dr� Inken König Institut für Medizinische Biometrie und Statistik Universität zu Lübeck, Lübeck Prof� Dr� Gisa Tiegs Institut für Experimentelle Immunologie und Hepatologie Universitätsklinikum Eppendorf, Hamburg Prof. Dr. Erika von Mutius Dr. von Haunersches Kinderspital Ludwig-Maximilians-Universität München, München Impressum Herausgeber Design Prof� Dr� S� Ehlers kc-graphics, Itzstedt Koordination Druck Dr. B. C. Brand WIRmachenDRUCK GmbH, Backnang Bilder Fotolia: Seiten 1/132, 8, 22, 28/29, 34, 50, 54, 58, 70, 74, 116, 118 4 Sehr geehrte Leserin, sehr geehrter Leser ... Das Forschungszentrum Borstel (FZB) ist das Lungenforschungszen- modernsten Erfordernissen an Tierhaltung, biologischer Sicherheit, trum der Leibniz-Gemeinschaft. Sein Erfolgskonzept beruht darauf, Laborqualität und Nachhaltigkeit entspricht. dass die im Kern translationale Forschung auf wenige, definierte Fragen zu Pathogenese, Diagnostik und Therapie chronisch-ent- Der vorliegende Forschungsbericht informiert in kompakter Form zündlicher Lungenerkrankungen fokussiert ist� Das FZB verfügt über die wissenschaftlichen Aktivitäten des Forschungszentrums über eine ausgeprägte, interdisziplinäre Expertise im Bereich der Borstel in den Jahren 2015 und 2016� Der Magazinteil berichtet mole kularen Mikrobiologie und der Strukturbiologie mikrobieller über Aktivitäten des Zentrums, besondere Initiativen, bewegende Bestandteile und Allergene. Diese Expertise wird kombiniert mit Ereignisse und wichtige Forschungsergebnisse, Verbundaktivitäten einer Vielfalt zellbiologischer und tierexperimenteller Modellsyste- und neue Forschungsgruppen. Exemplarisch ausgewählte Projekte me für die Asthma- und Tuberkulose-Forschung. Die wissenschaft- der Forschungsteams zeigen sowohl die Kernkompetenzen auf als lichen Schwerpunkte (Asthma/Allergien und infektionsbedingte, auch die erbrachten Leistungen� chronische Lungenerkrankungen) werden in zwei Programmbe- reichen (PB) von der Grundlagen- bis in die Klinische Forschung Auf diese Weise möchten wir nicht nur versierten Kolleginnen bearbeitet. Die zum FZB gehörende pneumologische Fachklinik und Kollegen, sondern auch einer breiteren Öffentlichkeit unsere und der Bereich Medizin (Klinische Pathologie, Biobank, Klinisches wissenschaftlichen Fragestellungen und Ziele näher bringen, und Studienzentrum) ermöglichen Studien nicht nur an humanem darüber hinaus auch die Fortschritte aufzeigen, die wir in den bei- Untersuchungsmaterial, sondern auch am Patienten. den vergangenen Jahren bei der Lösung gesellschaftlich relevanter medizinischer Probleme erzielt haben� Das FZB hat in den letzten zwei Jahren die qualitativ hochkarätigsten Veröffentlichungen seit seiner Gründung vor 70 Jahren erstellt und Veränderung ist unser Motto – für eine exzellente Forschung zum ist mit seiner Verbundforschung weiterhin überaus erfolgreich in Nutzen der Gesellschaft! Stolz sind wir auf das hervorragende der strategischen Drittmitteleinwerbung. Diese Leistungsfähigkeit Engagement aller unserer Mitarbeiterinnen und Mitarbeiter, ein und –bereitschaft hat die Zuwendungsgeber überzeugt, dem FZB herzlicher Dank gilt allen Freunden und Förderern aus Wissen- Investitionsmittel in Höhe von € 40 Millionen zuzusichern, um bis schaft, Politik und Wirtschaft. Mit Ihrer Unterstützung blicken wir zum Jahre 2021 ein neues zentrales Laborgebäude zu errichten, das optimistisch in die Zukunft! Dear Reader ... The Forschungszentrum Borstel (FZB) is the Lung Research Center The present report informs about the scientific activities of the of the Leibniz Association. Its continued success is based on trans- Forschungszentrum Borstel in the years 2015 and 2016 in a com- lational research focusing on a few, clearly defined questions regar- pact form. The magazine section reports on activities, specific ding pathogenesis, diagnostics and therapy of chronic inflammatory initiatives, important research results, scientific networks and new lung diseases. The FZB has a highly reputable interdisciplinary ex- research teams. By way of examples, hand-picked projects of the pertise in molecular microbiology and structural biology of micro- research groups and clinical units illustrate both the core compe- bial compo nents and allergens. These capabilities are combined tences and the achieved accomplishments. with a variety of cell biological and animal models in
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    ii2 Arch Dis Child 2000;82(Suppl II):ii2–ii5 The burden of childhood asthma Arch Dis Child: first published as 10.1136/adc.82.suppl_2.ii2 on 1 June 2000. Downloaded from Erika von Mutius Abstract Prevalence of childhood asthma and Paediatric asthma is a major clinical con- associated symptoms cern worldwide and represents a huge The ISAAC study compared the prevalence burden on family and society. It accounts rates of asthma and atopic disease in 155 cen- for a large number of lost school days and tres in 56 countries worldwide, and was may deprive the child of both academic conducted over a period of one year in 721 601 3 achievement and social interaction. children aged either 6–7 years or 13–14 years. Childhood asthma also places strain on Overall, the prevalence of asthma tended to be healthcare resources as a result of doctor greater in English speaking countries, but the and hospital visits and the cost of treat- international pattern was suggestive that envi- ment. The prevalence of asthma varies ronmental factors may have played a role in the worldwide, possibly because of diVerent prevalence of childhood asthma. exposure to respiratory infection, indoor Evidence from the ISAAC study also showed and outdoor pollution, and diet. Certain that the distribution of childhood asthma varies between global populations from less than 2% risk factors appear to predispose children to approximately 33% of the population. to developing asthma and atopic disease, Prevalence reaches 17–30% in the UK, New including incidence and severity of wheez- Zealand, and Australia, whereas areas of low ing, atopy, maternal smoking, and prevalence (1–7%) include Eastern Europe, number of fever episodes.
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