Massachusetts Eye and Ear Infirmary Quality and Outcomes 2012
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This Is a Program Where Learning Is Valued and the Educational Experience Is Tangible
“This is a program where learning is valued and the educational experience is tangible. You will learn a vocation, but it differs from many other schools in that HMS is a very academic environment. This is a place where a trainee can approach a faculty member and count on getting help. People coming from other institutions are simply struck by the emphasis we place on medical education.” — Simmons Lessell, MD, Director of Ophthalmic Medical Student Education, Harvard Medical School 113 M Today, about 1 in 6 ophthalmology department EDICAL Innovate. Train. Mentor. Inspire. chairs in academic institutions across the U.S. and EDUCATION Medical education is integral to the HMS Department of Ophthalmology’s mission, Canada conducted postdoctoral training at HMS. and trainees receive the finest ophthalmic education in the world. The depart- ment supports full-time faculty in every ophthalmic subspecialty, giving residents S a comprehensive grounding in ocular disease and management. Moreover, fellows ETTING have the opportunity to gain further clinical expertise or pursue in-depth research students have the opportunity to • Visual functions and developing mology is an area of medicine they evaluate, triage, and manage pa- technologies for visual rehabilita- would like to pursue. Elective rota- S in one or more of nine subspecialty areas. Under the exceptional leadership of John tients, and learn how to use special- tion tions also provide excellent train- TANDARD I. Loewenstein, MD, HMS Ophthalmology Vice Chair for Medical Education and ized ophthalmic equipment, includ- ing for students who may choose a ing the slit-lamp biomicroscope, the According to Dr. -
31St Biennial Cornea Conference
31st Biennial Cornea Conference Friday, September 20, 2019 8:00 – 8:30am Breakfast and Registration 8:30 – 8:45am Welcome and Introduction Reza Dana, MD, MPH, MSc and Ula Jurkunas, MD 8:45 – 10:50am Session 1: Ocular Surface Moderated By: Ilene K. Gipson, PhD 8:45 – 9:05am Role of Glycosylation in Epithelial Barrier Function Pablo Argüeso, PhD Associate Professor of Ophthalmology, Harvard Medical School Senior Scientist, Schepens Eye Research Institute of Mass. Eye and Ear 9:05 – 9:25am Protection of the Ocular Surface M. Elizabeth Fini, PhD Professor of Ophthalmology Tufts University School of Medicine at Tufts Medical Center 9:25 – 9:45am The Role of the Nervous System in Oral and Ocular Organ Regeneration Sarah Knox, PhD Assistant Professor, Department of Cell & Tissue Biology University of California, San Francisco 9:45 – 10:05am A Transgenic Biosensor Mouse Model for Studying Corneal Homeostasis, Wound-Healing and Limbal Stem Cell Deficiency Nick Di Girolamo, BSc, PhD Director, Ocular Diseases Research Head, Mechanisms of Disease and Translational Research Department of Pathology, School of Medical Sciences University of New South Wales, Australia 10:05 – 10:25am Challenges in the Management of Neurotrophic Keratopathy Natalie Afshari, MD, FACS Professor of Ophthalmology Stuart I. Brown, MD, Chair in Ophthalmology in Memory of Donald P. Shiley Chief, Division of Cornea and Refractive Surgery Vice Chair of Education, Shiley Eye Institute at UC San Diego Health 10:25 – 10:50am Discussion 10:50 – 11:35am Break, Poster Viewing 11:35am – 1:15pm Session 2: Immunology and Microbiology Moderated By: Mihaela Gadjeva, PhD, MSc Updated 8/12/19 31st Biennial Cornea Conference 11:35– 11:55am Advancing Diagnostics and Treatment of Infectious Keratitis through Innovation Paulo Bispo, PhD Assistant Scientist, Department of Ophthalmology, Harvard Medical School, Mass. -
Interferon May Offer First Drug Therapy for Diabetic Retinopathy
CLINICAL NEWS he says, "studies of angiogenesis have led to a new understanding of some of the vascular complications of diabetes." Angiogenesis was first linked to Interferon May Offer First Drug interferon —10 yr ago. Until then, in- Therapy for Diabetic terferon has been known mainly for its ability to stimulate the production of T Retinopathy lymphocytes. Then studies showed that the protein could slow the migration of New Research Showing That a-Interferon endothelial cells during the growth of new blood vessels. Soon after, other re- Blocks New Blood Vessel Formation in the Iris searchers showed that a-interferon slows down blood vessel growth in of Monkeys May Point the Way to New mice. In 1989, Carl W. White and Treatment for Diabetes Retinopathy. colleagues at the University of Colorado Health Sciences Center in Denver used a-interferon to treat a child with a he- mangioma, a mass resulting from the proliferation of capillaries. Hemangio- ye researchers are looking to the sudden loss of vision. The scarring that mas can occur anywhere in the body, immune system for new ways to accompanies recurrent hemorrhaging and can be fatal when they occur in E prevent, treat, or reverse prolifera- can lead to permanent loss of vision. certain organs. White's patient had a tive retinopathy, the most serious form Approximately 700,000 people hemangioma in the lung, a rare and of diabetic retinopathy. in the United States have proliferative usually fatal condition. Treatment with Proliferative retinopathy is retinopathy, with —65,000 new cases interferon, however, caused the heman- marked by the development of new being diagnosed each year. -
Mass. Eye and Ear and Schepens Eye Research Institute Unite Forces
Eyewitness THE NEWSLEttER OF THE HARVARD MEDICAL SCHOOL Department of Ophthalmology NOTES FROM THE CHAIR FALL/WINTER 2011 #18 Mass. Eye and Ear and Schepens Eye Research Institute Unite Forces ushing new boundaries that propel vision research forward is a hallmark of our department Pand, in June, led us to fulfill an exciting and historical agreement with the announcement that the Boards of two of our esteemed affiliates - Massachusetts Eye and Ear Infirmary and Schepens Eye Research Institute (Schepens) – have agreed to join forces. This powerful new alliance creates the largest and most dynamic basic and clinical ophthalmology research enterprise in the world, uniting a passionately dedicated team of nearly 100 full-time HMS investigators and clinician scientists whose talents and expertise span a full spectrum of eye diseases and scientific disciplines. Both institutions will operate under the direction of Mass. Eye and Ear’s Board of Directors, while Schepens will retain its name and continue as a non-profit research center. Joan W. Miller, MD Chief and Chair continues on page 4 Schepens in the Mass. Eye and Ear Family ass. Eye and Ear has long enjoyed a close Mcollaboration with nearby Schepens Eye Research Institute (Schepens), a leading eye research organization. In June 2011, Schepens and Mass. Eye and Ear officially combined forces to create the world’s largest and most robust basic and clinical ophthalmology research enterprise. Nearly 100 full-time investigators and clinician scientists form a full spectrum of ophthalmic talent and resources dedicated to accelerating bench-to-bedside discoveries. Schepens triumvirate leadership team (l to r): Reza Dana, MD, MPH, MSc, History of Schepens Eye Research Institute Patricia D’Amore, MD, MBA, Eliezer (Eli) Peli, MSc, OD In the late 1940s, as a researcher in the Howe Laboratory was later renamed the Schepens Eye Research Institute of Ophthalmology at Mass. -
Parisa Emami-Naeini, M.D., M.P.H
Parisa Emami-Naeini, M.D., M.P.H. Clinical Interests Dr Emami is a vitreoretinal surgeon and uveitis specialist at UC Davis Eye Center. She specializes in both medical and surgical management of various retinal diseases, including macular degeneration, diabetic retinopathy, retinal vascular disease, retinal degeneration, macular hole, epiretinal membrane and uveitis. Research/Academic Interests Dr. Emami's research interests include retinal imaging, pathogenesis and management of ocular inflammation/uveitis. Title Director of the Uveitis and Ocular Inflammation Service Assistant Professor Specialty Ophthalmology, Vitreoretinal Surgery, Uveitis Department Ophthalmology & Vision Science Division Ophthalmology Clinic Ophthalmology Clinic Address/Phone Lawrence J. Ellison Ambulatory Care Center, Ophthalmology Clinic-Eye Center, 4860 Y St. Suite 2400 Sacramento, CA 95817 Phone: 916-734-6602 Cadillac Drive Facility, Laser Vision Correction Services - Department of Ophthalmology and Vision Science, 77 Cadillac Dr. Suites 101 & 120 Sacramento, CA 95825 Phone: 916-734-6650 Additional Phone Clinic Phone: 916-734-6602 Physician Referrals: 800-4-UCDAVIS (800-482-3284) Languages Farsi Education M.D., M.P.H., Tehran University of Medical Sciences, Tehran, Iran 2009 Internships Metro West Medical Center, Harvard Medical School, Framingham MA 2012-2013 Residency Ophthalmology, Kresge Eye Institute Wayne State University, Detroit MI 2013-2016 Fellowships Uveitis, Cleveland Clinic Cole Eye Institute, Cleveland OH 2018-2019 Parisa Emami-Naeini, M.D., M.P.H. -
Frontiers in Ophthalmology 2011
Harvard Medical School Department of Ophthalmology Harvard Medical School Department of Ophthalmology Frontiers in Ophthalmology 2011 Produced by the HMS Department of Ophthalmology 243 Charles Street, Suite 800 CONTENTS Boston, Massachusetts 02114 (617) 573-3526 www.MassEyeAndEar.org [email protected] 2 WELcoME Editors-in-Chief Senior Writer/Editor: Suzanne Ward Joan W. Miller , MD Publications Manager 6 PeopLE & PARtneRS Chief and Chair HMS Ophthalmology Vice Chairs Department of Ophthalmology Scientific Communications Affiliate and Partner Profiles Massachusetts Eye and Ear Infirmary Consultant: Discoveries Making a Difference Massachusetts General Hospital Wendy Chao, PhD Collaborating to Cure Harvard Medical School Review Committee: John I. Loewenstein, MD Wendy Chao, PhD Associate Professor of Janet Cohan 46 LIFE-TRAnsFORMING CARE Ophthalmology Kathryn Colby MD, PhD Age-Related Macular Degeneration Harvard Medical School Mary Leach Ocular Oncology Associate Chief for Graduate Melissa Paul Clinical Innovations Medical Education Reza Dana, MD, MPH, MSc Keratoprosthesis Massachusetts Eye and Ear Infirmary Jennifer Street Vision Rehabilitation Janey Wiggs, MD, PhD Special thanks to the HMS Writing Credits: Department of Ophthalmology Vannessa Carrington 72 ReseARCH & DIscoVERY Vice Chairs: Judith Gibian Cornea Mary Leach Uvea Lloyd P. Aiello, MD, PhD Melissa Paul Retina HMS Vice Chair, Centers of Charles Ruberto, PhD Optic Nerve/Glaucoma Excellence Melanie Saunders Beetham Eye Institute at Joslin Jennifer Street Diabetes Center -
New VEGF Antagonists in AMD – New Quandaries Abound
4 By Nick Lane PhD New VEGF antagonists in AMD – new quandaries abound predominantly classic CNV most suitable But here is the rub. Ranibizumab is a Of course, in both advanced cancer and for treatment with verteporfin PDT. molecular cousin of a larger antibody, wet AMD, angiogenesis is an important Even so, despite the relatively slow known as bevacizumab (molecular weight factor in determining outcome. Genentech disease progression, patients treated with 148 kDa), marketed by Genentech as felt that bevacizumab was too big to ® ffective vascular-endothelial growth- ranibizumab experienced a mean increase Avastin . Engineered on the DNA level, penetrate the retina by intravitreal factor (VEGF) antagonists have been of seven letters VA at 12 months, while ranibizumab has several specific base injection; and while life-threatening adverse a long time coming, after first being patients in the control group had a mean changes that increase its affinity to VEGF. events (a higher risk of thromboembolic E decrease of 10.5 letters. Some 34% of the The FDA approved bevacizumab for events such as stroke and MI) might be proposed back in the 1970s; but now, like London buses, three have arrived at once 0.5 mg-treatment group experienced a treating advanced colorectal cancer in acceptable in treating advanced cancer, for the treatment of wet AMD. Far from better than15-letter gain in VA, compared February 2004, and it is still in trials for systemic treatment with bevacizumab for being just ‘me-too’ drugs in the same class, with 4.6% in the control group. other forms of cancer. -
779Th Meeting of the New England Ophthalmological Society
779th meeting of the New England Ophthalmological Society NEW DRUGS IN OPHTHALMOLOGY: FROM DROPS TO DRIPS with The Stephen Foster Lecture on Ocular Inflammation RETINAL DETACHMENT: DIAGNOSIS, MANAGEMENT, AND CHALLENGES with The Joan W. Miller, MD Lecture April 24, 2020 Virtual meeting available at WWW.NEOS-EYES.ORG th th The 779 Meeting of the 779 meeting of The New England Ophthalmological Society, Inc. A Public Foundation for Education in Ophthalmology Virtual meeting available at WWW.NEOS-EYES.ORG The New England Ophthalmological Society, Inc. A Public Foundation for Education in Ophthalmology April 24, 2020 NEW DRUGS IN OPHTHALMOLOGY: FROM DROPS TO DRIPS VIRTUAL MEETING AVAILABLE AT April 24, 2020 WWW.NEOS-EYES.ORG Lucia Sobrin, MD, MPH, Moderator and Program Committee Coordinator ------------------------------------------------------- NEW DRUGS IN OPHTHALMOLOGY: FROM DROPS TO DRIPS WITH THE STEPHEN FOSTER LECTURE ON OCULAR INFLAMMATION RETINAL DETACHMENT: DIAGNOSIS, MANAGEMENT, AND CHALLENGES Peter Chang, MD, Moderator Lucia Sobrin, MD, MPH, Moderator and Program Committee Coordinator Brian Kim, MD, Program Committee Coordinator RETINAL DETACHMENT: DIAGNOSIS, MANAGEMENT, AND CHALLENGES ------------------------------------------------------- WITH JOAN W. MILLER, MD LECTURE Peter Chang, MD, Moderator Brian Kim, MD, Program Committee Coordinator AMA Credit Designation Statement The New England Ophthalmological Society designates this enduring material for a maximum of 4.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit AMA Credit Designation Statement commensurate with the extent of their participation in the activity. The New England Ophthalmological Society designates this enduring material for a maximum of 4.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit Accreditation Statement commensurate with the extent of their participation in the activity. -
Angiogenesis
Angiogenesis An Integrative Approach From Science to Medicine Angiogenesis An Integrative Approach From Science to Medicine Edited by William D. Figg Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA Judah Folkman Department of Surgery, Harvard Medical School and Vascular Biology Program, Children’s Hospital Boston, Boston, Massachusetts, USA Editors William D. Figg Judah Folkman Medical Oncology Branch Department of Surgery Center for Cancer Research Harvard Medical School and National Cancer Institute Vascular Biology Program Bethesda, Maryland Children’s Hospital Boston USA Boston, Massachusetts USA ISBN: 978-0-387-71517-9 e-ISBN: 978-0-387-71518-6 DOI: 10.1007/978-0-387-71518-6 Library of Congress Control Number: 2007934647 © 2008 Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science + Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. -
Judah Folkman 1933–2008
Judah Folkman 1933–2008 A Biographical Memoir by Patricia K. Donahoe ©2014 National Academy of Sciences. Any opinions expressed in this memoir are those of the author and do not necessarily reflect the views of the National Academy of Sciences. MOSES JUDAH FOLKMAN February 24, 1933–January 14, 2008 Elected to the NAS, 1990 Moses Judah Folkman was born in 1933 in Cleveland, Ohio. He was the oldest child of a distinguished line of rabbis whose influence on the young man—particularly that of his father, Rabbi Jerome Folkman—is legendary. His mother, Bessie Schomer Folkman, instilled in him a love of science with bedtime stories about Newton, Pasteur, and Madame Curie. A move to Columbus during high school put Folkman under the tutelage of Robert Zollinger, who spotted him working at Ohio State University Hospital as a volunteer aide and invited him to work in his laboratory afternoons and weekends. There in the Zollinger Laboratory, where he worked throughout college, Folkman had the oppor- By Patricia K. Donahoe tunity to learn surgical skills and published a paper about liver cooling in the journal Surgery. He was accepted at Harvard Medical School in 1953 and worked in the laboratories of Robert E. Gross, from whom he learned the “obsessive perseverance” required for his future life as a surgeon scientist. Folkman also helped to develop a heart-lung bubble oxygenator, which was initially used for repair of ventricular septal defects, and he designed a prototype transistorized pacemaker with Massachusetts Institute of Technology graduate student Fred Vanderschmidt. The heart lung machine and the pacemaker, though perfected in other laboratories, provided the tools to realize Gross’s dream of innovating and making cardiac surgery routine for infants and children (Cooke 2001). -
The Vision of One Special Patient
THE NEWSLETTER OF THE HARVARD MEDICAL SCHOOL D epartment of Ophthalmology EyewitnessSPECIAL GRADUATION IssUE SPRING/SUMMER 2011 #17 NOTES FROM THE CHAIR procedures. As a graphic artist his visual The Vision of perception was particularly precious to him, and he certainly mourned its One Special Patient loss. However, he set out to find ways s an ophthalmologist specializing to adapt. A in blinding retinal diseases such as Rob moved into a senior independent age-related macular degeneration (AMD), living facility so that he wouldn’t spend I have always believed in life-long learning all of his energy managing day-to-day through journal articles, professional living. He discovered that many others societies, and the probing questions of our in the facility had vision problems and brilliant trainees. But it is from my patients developed a program of lectures and that I learn what no seminar or publication Dr. Joan Miller with Seymour Robins an exhibition by vendors of visual aids can teach: how they cope day-to-day with in 2008. Photo by Don Victor and equipment. He started to write the trappings of their disease, what they about living with macular degeneration, lose (and sometimes gain) along the way, how medical sharing his witty anecdotes in his prose. With his treatment affects their vision and their lives, and how they observational skills heightened by his training as a graphic often transcend the challenges of visual disability. artist, Rob fastidiously documented his altered visual Seymour “Rob” Robins was a remarkable individual and perceptions. In 2005, he published Vision Junkie: Essays a patient of mine from 1999 until his recent death at and Other Writings from the Parallel World of the Legally age 97. -
Image of the Month the Human Choroid, Reconstructed in 3D
APRIL 2016 # 29 Image of the Month Upfront Profession Sitting Down With The human choroid, Growing your own Benchmarking your practice Amar Agarwal, Chairman of reconstructed in 3D crystalline lens against your peers Dr Agarwal’s Eye Hospital 03 08 – 10 60 – 64 66 – 67 www.theophthalmologist.com DUAL-SEGMENT PUMP TECHNOLOGY + Precise fluidics + Pulsatile-free + Quick vacuum rise + Versatile performance PERFORMANCE IN EVERY DETAIL Superior chamber stability through superior engineering.†,1,2 That’s the Centurion® Effect. Active Fluidics™ Technology • Helps to Maintain Chamber Stability: Detects and compensates to help provide superior chamber stability3 compared to INFINITI®4 • Less Surge: Less surge at any tested vacuum level3,5 • More Consistent IOP4 : Up to 80% less surge area3,5 Contact your Alcon representative to schedule a demonstration and experience the Centurion® Effect for yourself. †As compared to the INFINITI® Vision System, bottle gravity system. 1. Lorente R, Fanney D, Injev V, Sharif-Kashani P. Quantification of occlusion break surge in peristaltic-based phacoemulsification systems. ASCRS-ASOA Symposium and Congress; April 25-29, 2014; Boston, USA.2. Nicoli M, Miller K, Dimalanta R, Loke D; Jules Stein Eye Institute, UCLA. IOP Stability Measurement and Comparison Between Gravity-Fed and Actively Controlled Phacoemulsification Systems. 2014. 3. Sharif-Kashani P, Fanney D, Injev V. Comparison of occlusion break responses and vacuum rise times of phacoemulsification systems. BMC Ophthalmol. 2014;14:96. 4. Nicoli CM, Dimalanta R, Miller K. Experimental anterior chamber maintenance in active versus passive phacoemulsification fluidics systems. J Cataract Refract Surg. 2016;42(1):157-162. 5. Alcon data on file.