Fall 2014 Gluten Free New England
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Celiac Disease and Nonceliac Gluten Sensitivitya Review
Clinical Review & Education JAMA | Review Celiac Disease and Nonceliac Gluten Sensitivity A Review Maureen M. Leonard, MD, MMSc; Anna Sapone, MD, PhD; Carlo Catassi, MD, MPH; Alessio Fasano, MD CME Quiz at IMPORTANCE The prevalence of gluten-related disorders is rising, and increasing numbers of jamanetwork.com/learning individuals are empirically trying a gluten-free diet for a variety of signs and symptoms. This review aims to present current evidence regarding screening, diagnosis, and treatment for celiac disease and nonceliac gluten sensitivity. OBSERVATIONS Celiac disease is a gluten-induced immune-mediated enteropathy characterized by a specific genetic genotype (HLA-DQ2 and HLA-DQ8 genes) and autoantibodies (antitissue transglutaminase and antiendomysial). Although the inflammatory process specifically targets the intestinal mucosa, patients may present with gastrointestinal signs or symptoms, extraintestinal signs or symptoms, or both, Author Affiliations: Center for Celiac suggesting that celiac disease is a systemic disease. Nonceliac gluten sensitivity Research and Treatment, Division of is diagnosed in individuals who do not have celiac disease or wheat allergy but who Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for have intestinal symptoms, extraintestinal symptoms, or both, related to ingestion Children, Boston, Massachusetts of gluten-containing grains, with symptomatic improvement on their withdrawal. The (Leonard, Sapone, Catassi, Fasano); clinical variability and the lack of validated biomarkers for nonceliac gluten sensitivity make Celiac Research Program, Harvard establishing the prevalence, reaching a diagnosis, and further study of this condition Medical School, Boston, Massachusetts (Leonard, Sapone, difficult. Nevertheless, it is possible to differentiate specific gluten-related disorders from Catassi, Fasano); Shire, Lexington, other conditions, based on currently available investigations and algorithms. -
Faded Memories
Faded Memories Life and Times of a Macedonian Villager 1 The COVER PAGE is a photograph of Lerin, the main township near the villages in which many of my family ancestors lived and regularly visited. 2 ACKNOWLEGEMENTS This publication is essentially an autobiography of the life and times of my father, John Christos Vellios, Jovan Risto Numeff. It records his recollections, the faded memories, passed down over the years, about his family ancestors and the times in which they lived. My father personally knew many of the people whom he introduces to his readers and was aware of more distant ancestors from listening to the stories passed on about them over the succeeding generations. His story therefore reinforces the integrity of oral history which has been used since ancient times, by various cultures, to recall the past in the absence of written, documentary evidence. This publication honours the memory of my father’s family ancestors and more generally acknowledges the resilience of the Macedonian people, who destined to live, seemingly forever under foreign subjugation, refused to deny their heritage in the face of intense political oppression and on-going cultural discrimination. This account of life and times of a Macedonian villager would not have been possible without the support and well-wishes of members of his family and friends whose own recollections have enriched my father’s narrative. I convey my deepest gratitude for the contributions my father’s brothers, my uncles Sam, Norm and Steve and to his nephew Phillip (dec), who so enthusiastically supported the publication of my father’s story and contributed on behalf of my father’s eldest brother Tom (dec) and his family. -
Food Allergy and Sensitivity Test (FAST) Results Fast Track to Wellness
Food Allergy and Sensitivity Test (FAST) Results Fast Track To Wellness Infinite Allergy Labs | 3885 Crestwood Parkway Ste 550, Duluth, Georgia 30096 | 1-833-FOODALLERGY The information in this guide will help you to understand the Infinite Allergy Labs Food Allergy and Sensitivity Panel (FAST), and how to best utilize your results. Why Food Testing Matters: Many people realize that they are having issues with food and can tell something in their diet is affecting them. They are often led to allergy testing and may find some answers but not the entire solution. Allergy testing is useful, but only looks at one way we react to foods. Allergy testing measures an immune response known as IgE. Our body can be inflamed in different ways, not only from IgE, but Total IgG, IgG4, and complement. A diet that minimizes foods that provoke these responses will decrease many types of inflammation and symptoms and is foundational to wellness. When we are eating the least inflammatory diet, individualized to our body, we are optimizing our chance for health. Inflammation can be due to certain foods specific to each individual and is at the heart of many conditions that are detrimental to health and quality of life. Considering that the surface area of our intestines is almost the size of a football field, controlling even a small amount of this inflammation, provides huge benefits to health. Research continues to emerge regarding the consequences of inflammation in our gut and how foods trigger an inflammatory process. As inflammation decreases, the intestinal lining or “gut” begins to heal. -
NIH Public Access Author Manuscript Psychiatr Q
NIH Public Access Author Manuscript Psychiatr Q. Author manuscript; available in PMC 2013 May 02. NIH-PA Author ManuscriptPublished NIH-PA Author Manuscript in final edited NIH-PA Author Manuscript form as: Psychiatr Q. 2012 March ; 83(1): 91–102. doi:10.1007/s11126-011-9186-y. Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten Sensitivity Jessica R. Jackson, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Box 21247, Baltimore, MD 21228, USA William W. Eaton, Johns Hopkins School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA Nicola G. Cascella, Johns Hopkins School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA Alessio Fasano, and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD, USA Deanna L. Kelly Maryland Psychiatric Research Center, University of Maryland School of Medicine, Box 21247, Baltimore, MD 21228, USA Deanna L. Kelly: [email protected] Abstract Celiac Disease (CD) is an immune-mediated disease dependent on gluten (a protein present in wheat, rye or barley) that occurs in about 1% of the population and is generally characterized by gastrointestinal complaints. More recently the understanding and knowledge of gluten sensitivity (GS), has emerged as an illness distinct from celiac disease with an estimated prevalence 6 times that of CD. Gluten sensitive people do not have villous atrophy or antibodies that are present in celiac disease, but rather they can test positive for antibodies to gliadin. Both CD and GS may present with a variety of neurologic and psychiatric co-morbidities, however, extraintestinal symptoms may be the prime presentation in those with GS. -
Tempters and Gluten-Free Diet
nutrients Editorial Tempters and Gluten-Free Diet Carlo Catassi 1,* and Alessio Fasano 2,* 1 Department of Pediatrics, Università Politecnica delle Marche, Ancona 60121, Italy 2 Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Boston, MA 02129, USA * Correspondence: [email protected] (C.C.); [email protected] (A.F.); Tel.: +39-071-596-2364 (C.C.); +1-617-726-1450 (A.F.) Received: 16 November 2016; Accepted: 25 November 2016; Published: 3 December 2016 To the tempter that came to Him and said, “If You are the Son of God, tell these stones to become bread”. Jesus replied “It is written: man shall not live on bread alone ... ” (Matthew 4:4). Nowadays, many people, particularly in the Western world, have gone well beyond that holy recommendation. In a 2014 US Consumer Reports survey, 63% of participants said they felt that avoiding bread and other gluten-containing food would improve their physical or mental health. Moreover, in a 2015 Gallup Poll, 21% of Americans reported they tried to include gluten-free foods in their diet. The “fall” of gluten might be related to the increased awareness of gluten-related disorders and the recent surge of prevalence of celiac disease (CD) and non-celiac gluten sensitivity (NCGS). This trend could still be on the rise, particularly in areas of the world undergoing a progressive “Westernization” of the diet, as suggested here by Peña and coworkers who note that the diet of people living in Central America is shifting from a maize- to a wheat-based diet [1]. Not surprisingly in Mexico Ontiveros et al. -
A Taste of Macedonia
A Taste of Macedonia Traditional Macedonian Recipes Macedonian Australian Welfare Association of Sydney Inc. Acknowledgments Macedonian Australian Welfare Association of Sydney Inc. (MAWA) would like to acknowledge the Macedonia FAQ (frequently asked questions) website where these recipes were compiled. MAWA would also like to thank and acknowledge “Multicultural Recipes for Every Day” published by St. George (Multicultural Day Care Program) Migrant Resource Centre. Aim Now in its second printing this Macedonian recipe book has been complied with a view to providing culturally appropriate menu options to aged care services. It was been published in the hopes that the cultural identify of Macedonian people in residential aged care and aged care services in the Sydney area is maintained and encouraged. Table of Contents Appetizers, Bread and Salad Ajvar (Relish Dip) ……………………………….………………………………… 6 Leb (Bread) …………………………………………………………………………. 7 Turshija (Jernikitz Peppers) …………………………………………………… 8 Shopska Salata (Shopska Salad) ……….…………………………………… 9 Tarator (Cucumber Yoghurt Salad) ……………………………………….. 10 Turkish Coffee (Macedonian Espresso) ……………….………………….. 11 Main Courses Tava so Oriz (Macedonian Chicken Stew) …….….……………………… 13 Kjebapchinja (Macedonian Sausages) ……………………………………… 14 Kjoftinja (Meatballs) …………………………………………………………….. 15 Musaka ………………………………………………………………………………. 16 Muchkalica from Shar Planina ……………………………………………….. 17 Pastrmajlija (Macedonian Pizza) ……………………………………………. 18 Pecheno Jagne so Zelka (Steamed Lamb with Cabbage) …………. 19 Polneti Piperki -
Gluten Sensitivity: Real Or Not (People Shall Not Live by Bread Alone..)
9/17/2013 Gluten Sensitivity: Real or Not (People Shall Not Live by Bread Alone..) Alessio Fasano, M.D. Mucosal Immunology and Biology Research Center And Center for Celiac Research Massachusetts General Hospital, Boston MA – U.S.A. Conflict of Interest In the past 12 months, I have had the following relevant financial relationships with the following manufacturer of any commercial product(s) and/or provider(s) of commercial services discussed in this CME activity: ALBA THERAPEUTICS, CO-FOUNDER AND STOCK HOLDER I will not discuss any product from Alba Therapeutics in my presentation. I do not intend to discuss an unapproved or investigative use of a commercial product or device in my presentation. NEWS #1: Why Gluten is Toxic 1 9/17/2013 Dietary Factors The Grass Family - (GRAMINEAE) Subfamily Festucoideae Tribe Hordeae Oryzeae Zizaneae Aveneae Festuceaea Chlorideae Wheat rice wild rice oat finger millet teff Years rye 2.5 M 2009 The Human race appears on the face of hearth barley 10,000 Change from nomadic to settled life style Diet Fruits, nuts, tubers Occasional meat Advent of agriculture Development of gluten containing grains Grain Evolution + T. turgidum AABB Aegilops tauschii DD T. aestivum AABBDD 28 chromosomes 14 chromosomes 42 chromosomes 100,000 genes 50,000 genes 150,000 genes THE GRAINS IN THE PAST WERE DIFFERENT FROM THE CURRENT GRAINS Pieter Bruegel, 1565 2 9/17/2013 What is so Special About Gluten? Gliadin Glutenin Gluten (gliadin+glutenin) Mapping of -gliadin motifs exerting cytotoxic activity (red), immunomodulatory activity (light green), zonulin release and gut permeating activity (blue) and CXCR3- dependent IL8 release in CD patients (dark green). -
Microbiota and Metabolomic Patterns in the Breast Milk of Subjects with Celiac Disease on a Gluten-Free Diet
nutrients Article Microbiota and Metabolomic Patterns in the Breast Milk of Subjects with Celiac Disease on a Gluten-Free Diet Katherine L. Olshan 1,2,3,4, Ali R. Zomorrodi 1,2,3,4, Meritxell Pujolassos 5 , Jacopo Troisi 5,6,7 , Nayeim Khan 8, Brian Fanelli 8, Victoria Kenyon 2,4, Alessio Fasano 1,2,3,4,6 and Maureen M. Leonard 1,2,3,4,* 1 Division of Pediatric Gastroenterology and Nutrition, MassGeneral Hospital for Children, Harvard Medical School, Boston, MA 02114, USA; [email protected] (K.L.O.); [email protected] (A.R.Z.); [email protected] (A.F.) 2 Mucosal Immunology and Biology Research Center, MassGeneral Hospital for Children, Boston, MA 02129, USA; [email protected] 3 Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA 02115, USA 4 Celiac Research Program, Harvard Medical School, Boston, MA 02115, USA 5 Theoreo srl, University of Salerno, 84084 Salerno, Italy; [email protected] (M.P.); [email protected] (J.T.) 6 Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, 84084 Salerno, Italy 7 European Biomedical Research Institute of Salerno (EBRIS), Via S. De Renzi, 50, 84125 Salerno, Italy 8 CosmosID Inc., Rockville, MD 20850, USA; [email protected] (N.K.); [email protected] (B.F.) * Correspondence: [email protected] Abstract: The intestinal microbiome may trigger celiac disease (CD) in individuals with a genetic disposition when exposed to dietary gluten. Research demonstrates that nutrition during infancy Citation: Olshan, K.L.; Zomorrodi, is crucial to the intestinal microbiome engraftment. -
Preschool Curriculum Framework Vol. 2
California Preschool Curriculum Framework Volume 2 CALIFORNIA DEPARTMENT OF EDUCATION • SACRAMENTO, 2011 California � Preschool Curriculum � Framework � Volume 2 Visual and Performing Arts � Physical Development � Health � Publishing Information The California Preschool Curriculum Framework, Volume 2, was developed by the Child Development Division, California Depart- ment of Education. This publication was edited by Faye Ong and John McLean, working in cooperation with Laura Bridges, Consultant. It was designed and prepared for printing by the staff of CDE Press, with the cover and interior design created by Cheryl McDonald. It was published by the Department of Education, 1430 N Street, Sacramento, CA 95814-5901. It was distributed under the provisions of the Library Distribution Act and Government Code Section 11096. © 2011 by the California Department of Education All rights reserved ISBN 978-0-8011-1716-9 Ordering Information Copies of this publication are available for purchase from the California Department of Education. For prices and ordering information, please visit the Department Web site at http://www. cde.ca.gov/re/pn/rc or call the CDE Press Sales Office at 1-800- 995-4099. Notice The guidance in the California Preschool Curriculum Framework, Volume 2, is not binding on local educational agencies or other en- tities. Except for the statutes, regulations, and court decisions that are referenced herein, the document is exemplary, and compliance with it is not mandatory. (See Education Code Section 33308.5.) Contents � A Message from the State Superintendent Dance ....................................................... 101 � of Public Instruction ................................. v � 1.0 Notice, Respond, and Engage ........... 103 � Acknowledgments ........................................vii � 2.0 Develop Skills in Dance .................. -
Non-Celiac Gluten Sensitivity: the New Frontier of Gluten Related Disorders
Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Catassi, C., J. C. Bai, B. Bonaz, G. Bouma, A. Calabrò, A. Carroccio, G. Castillejo, et al. 2013. “Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders.” Nutrients 5 (10): 3839-3853. doi:10.3390/nu5103839. http://dx.doi.org/10.3390/nu5103839. Published Version doi:10.3390/nu5103839 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879062 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Nutrients 2013, 5, 3839-3853; doi:10.3390/nu5103839 OPEN ACCESS nutrients ISSN 2072-6643 www.mdpi.com/journal/nutrients Review Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders Carlo Catassi 1, Julio C. Bai 2, Bruno Bonaz 3, Gerd Bouma 4, Antonio Calabrò 5, Antonio Carroccio 6, Gemma Castillejo 7, Carolina Ciacci 8, Fernanda Cristofori 9, Jernej Dolinsek 10, Ruggiero Francavilla 9, Luca Elli 11, Peter Green 12, Wolfgang Holtmeier 13, Peter Koehler 14, Sibylle Koletzko 15, Christof Meinhold 16, David Sanders 17, Michael Schumann 18, Detlef Schuppan 19,20, Reiner Ullrich 18, Andreas Vécsei 21, Umberto Volta 22, Victor Zevallos 19, Anna Sapone 23 and Alessio Fasano 24,* 1 Department of Pediatrics, Università Politecnica delle Marche, Ancona 60121, Italy; E-Mail: [email protected] 2 Departamento de Medicina, Hospital de Gastroenterología “Dr. -
Role of Zonulin-Mediated Gut Permeability in the Pathogenesis of Some Chronic Inflammatory Diseases [Version 1; Peer Review: 3 Approved] Alessio Fasano 1,2
F1000Research 2020, 9(F1000 Faculty Rev):69 Last updated: 24 FEB 2020 REVIEW All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases [version 1; peer review: 3 approved] Alessio Fasano 1,2 1Mucosal Immunology and Biology Research Center, Center for Celiac Research and Treatment and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, Massachusetts, USA 2European Biomedical Research Institute of Salerno, Salerno, Italy First published: 31 Jan 2020, 9(F1000 Faculty Rev):69 ( Open Peer Review v1 https://doi.org/10.12688/f1000research.20510.1) Latest published: 31 Jan 2020, 9(F1000 Faculty Rev):69 ( https://doi.org/10.12688/f1000research.20510.1) Reviewer Status Abstract Invited Reviewers Improved hygiene leading to reduced exposure to microorganisms has 1 2 3 been implicated as one possible cause for the recent “epidemic” of chronic inflammatory diseases (CIDs) in industrialized countries. That is the version 1 essence of the hygiene hypothesis that argues that rising incidence of CIDs 31 Jan 2020 may be, at least in part, the result of lifestyle and environmental changes that have made us too “clean” for our own good, so causing changes in our microbiota. Apart from genetic makeup and exposure to environmental triggers, inappropriate increase in intestinal permeability (which may be F1000 Faculty Reviews are written by members of influenced by the composition of the gut microbiota), a “hyper-belligerent” the prestigious F1000 Faculty. They are immune system responsible for the tolerance–immune response balance, commissioned and are peer reviewed before and the composition of gut microbiome and its epigenetic influence on the publication to ensure that the final, published version host genomic expression have been identified as three additional elements in causing CIDs. -
Click on Alessio Fasano MD Webinar Description Page
11/5/2018 COPE WEBINAR SERIES FOR HEALTH PROFESSIONALS November 5, 2018 Gluten-Related Disorders: How to Distinguish Facts from Fantasies Moderator: Lisa Diewald MS, RD, LDN Program Manager MacDonald Center for Obesity Prevention and Education Nursing Education Continuing Education Programming Research FINDING SLIDES FOR TODAY’S WEBINAR www.villanova.edu/COPE Click on Alessio Fasano MD webinar description page DID YOU USE YOUR PHONE TO ACCESS THE WEBINAR? If you are calling in today rather than using your computer to log on, and need CE credit, please email [email protected] and provide your name so we can send your certificate. 1 11/5/2018 OBJECTIVES 1.Recognize the differences between celiac disease, non-celiac gluten sensitivity and wheat allergy. 2.Discuss the epidemiology of celiac disease and why prevalence is increasing 3.Identify the role of the gut microbiome and intestinal permeability in autoimmune disease CE DETAILS • Villanova University College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center Commission on Accreditation • Villanova University College of Nursing Continuing Education/COPE is a Continuing Professional Education (CPE) Accredited Provider with the Commission on Dietetic Registration • The American College of Sports Medicine’s Professional Education Committee certifies that Villanova University College of Nursing Continuing Education, Center for Obesity Prevention and Education (COPE) meets the criteria for official ACSM Approved Provider status