Protein Cell https://doi.org/10.1007/s13238-019-0629-9 Protein & Cell RESEARCH ARTICLE PCGF6 regulates stem cell pluripotency as a transcription activator via super-enhancer dependent chromatin interactions Xiaona Huang1,2,3,4 , Chao Wei1,2,3,4, Fenjie Li1,2,3,4, Lumeng Jia5, Pengguihang Zeng1,2,3, Jiahe Li1,2,3, Jin Tan1,2,3, Tuanfeng Sun1,2,3, Shaoshuai Jiang1,2,3, Jia Wang1,2,3, Xiuxiao Tang1,2,3, Qingquan Zhao1,2,3, Bin Liu6, Limin Rong6, Cheng Li5, Junjun Ding1,2,3,4,7& 1 RNA Biomedical Institute, Sun Yat-Sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China 2 Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Cell Education, Sun Yat-Sen University, Guangzhou 510080, China & 3 Department of Cell Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China 4 Program in Stem Cell and Regenerative Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China 5 Center for Bioinformatics, School of Life Sciences, Peking University, Beijing 100871, China 6 Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China Protein 7 Department of Histology and Embryology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China & Correspondence:
[email protected] (J. Ding) Received January 18, 2019 Accepted April 15, 2019 ABSTRACT pluripotency, and provide a research basis for the ther- apeutic application of pluripotent stem cells.