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Oral Manifestations of Hepatitis C Virus

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Oral Manifestations of Hepatitis C Virus http://dx.doi.org/10.5272/jimab.2013194.377 ISSN: 1312-773X (Online) Journal of IMAB - Annual Proceeding (Scientific Papers) 2013, vol. 19, issue 4 ORAL MANIFESTATIONS OF HEPATITIS C VIRUS Vladimir E. Panov Department of Conservative dentistry and oral pathology, Faculty of Dental Medicine, Medical University, Varna, Bulgaria SUMMARY: The DMFT index differed significantly between Hepatitis C virus (HCV) infection is a serious public hepatitis C and general patients. The number of decayed and health problem. New infections continue to occur, and missing teeth was greater in those infected with hepatitis C morbidity and mortality are increasing. The date reported that for all patients aged between 25 and 50 years. Although there 3% of infected world populations are affected. was no significant difference in CPITN categories for subjects Morbidity associated with hepatitis C virus infection evaluated, a marked trend for poor periodontal health was can involve a variety of extrahepatic conditions including the noted for those individuals with hepatitis C. Social impact was oral region. Some of the oral manifestation are oral disease significantly affected with 71 per cent of hepatitis C subjects like lichen planus and Sjögren-like sialadenitis, other affects reporting painful aching in the mouth and 56 per cent having the dental status, and side effect of the virus therapy. The aim difficulty in relaxing (4). of this review is to summarize the oral sings, accompanying Cases with periodontal disease showed higher hepatitis c virus. percentages of hepatitis exposure (hepex; anti HCV and/or anti HBc) and significantly higher anti HCV seropositivity Key words: hepatitis C, oral manifestation than the controls (26% and 13% versus 22% and 8%, respectively). Furthermore, cases with periodontal disease INTRODUCTION: showed higher detectability rate of HBsAg, anti HBc, anti Hepatitis C virus (HCV) infection is widespread with HCV or both anti HCV and/or anti HBc in whole unstimulated an estimated 3% of infected world population. Acute infection saliva than the controls (100% vs 66.7%, 50% vs 23.5%, is usually mild but chronicity develops in as many as 80% of 23.1% vs 0.0% and 42.3% vs 18.2%, respectively). patients, of whom at least 20% will eventually develop Periodontal disease, severity of bleeding and bad oral hygiene cirrhosis. Morbidity associated with HCV infection is due not were associated with the risk of hepatitis infection and with only to the sequelae of chronic liver disease, but also to a the detectability of hepatitis markers in the whole saliva (6). variety of extraheaptic manifestations (EHM) in 74% of all HCV-infected individuals. Some of the most frequently Lichen Planus reported EHM of HCV infection involves the oral region Lichen planus (LP) is a chronic mucocutaneous disease predominantly or exclusively (12). more commonly seen in middle-aged women and affecting up to 1-2% of the population. There is some evidence of an Uncommon oral signs association between HCV and oral lichen planus (OLP); The oral cavity can reflect liver dysfunction in the form however, this varies by region. OLP is often bilateral and of mucosal membrane jaundice, bleeding disorders, petechiae, typically presents as a mixture of clinical subtypes that increased vulnerability to bruising, gingivitis, gingival characteristically bear fine white striations known as bleeding (even in response to minimum trauma), foetor Wickham’s striae(1). Epidemiological data suggest that LP hepaticus (a characteristic odor of advanced liver disease), may be significantly associated with HCV infection, mainly cheilitis, smooth and atrophic tongue, xerostomia, bruxism, in Southern Europe and Japan (3). crusted perioral rash, oral soreness (11). All of these reported The reticular form has a lacy pattern of white lines manifestation and symptoms are uncommon oral signs and can while the papular type consists of small raised areas. The be seen also in other systemic disease. plaque-like variant appears similar to a leukoplakia. The atrophic form presents with erythematous patches. The erosive Dental Complications variant appears deep red in colour while the ulcerative type The date according dental status reveal that people appears as irregular and often large ulcerations. Bullous type with hepatitis C are prone to tooth decay, suffer loss of self- is extremely rare and often presents as either erosive or esteem due to poor oral aesthetics and have difficulty with ulcerative due to ruptured bullae. If affected on the gingivae, diet due to poor oral health, all leading to a compromised it often appears as erythematous and is called desquamative quality of life (4, 11). gingivitis. HCV seropositivity in the OLP patients was / J of IMAB. 2013, vol. 19, issue 4/ http://www.journal-imab-bg.org 377 significantly higher than in the healthy blood donors (15). antibody in patients with oral cancer, but this difference However, no relation was found between this disappeared when the data were adjusted for age(14). Oral association and a specific clinical form of the disease. Due verrucous and squamous cell carcinomas have been reported to the higher occurrence of HCV seropositivity in OLP in HCV infected patients with OLP (3, 9) and positive and patients, it is suggested that all Israeli patients diagnosed with negative HCV-RNA strands have been detected both in oral OLP be regularly screened for HCV antibodies (15). Common cancer tissues (9). symptoms are of burning or oral pain, especially with acidic However, HCV is a common cause of liver cirrhosis or spicy foods. Symptoms are often irrespective of the clinical which may represent itself an independent risk factor for the presentation(1). A possible link between hepatitis viruses and development of oral cancer (13). On the other hand, LP has been suggested by the fact that LP has been frequently potentially oral premalignant lesions such as leukoplakia and associated with chronic liver disease (CLD) in Mediterranean oral epithelial dysplasia are not associated with HCV infection but not in northern European patients (3). (3, 8). Data suggest that HCV but not HBV infection is a risk factor for oral cavity cancer Sjogren’s Syndrome, Sjögren-like Sialadenitis It is known that HCV affects the salivary glands but Side Effects of HCV Treatment the exact nature of this effect is yet to be fully understood. HCV treatment is generally well tolerated. However, Hepatitis C virus is thought to cause a syndrome with features current therapy is associated with a range of side effects, similar to Sjogren’s Sydnrome (SS) in a proportion of infected which in some are severe enough to lead to treatment individuals. It has been proposed HCV may lead to the cessation. These include more commonly experienced side development of SS; however, this link is contentious (2). effects such as irritability, dermatitis skin, hair loss, anorexia, It is unclear if the virus may cause a disease mimicking nausea, headaches, fever, myalgia, neutropaenia, primary SS or if HCV is directly responsible for the thrombocytopaenia, and anaemia. Less common side effects development of SS in a specific subset of patients. Notably, include those such as psychiatric disorders, diabetes, and some patients may present a triple association between HCV, thyroid dysfunction (2). SS-like sialadenitis and SG lymphoma and the virus may be Reported oral side effects after interferon and ribavirin involved in the lymphomagenesis. The risk of having a NHL treatment include gingival bleeding, gingival swelling, is particularly high in patients with MC. Little attention has toothache, gingivitis, periodontitis, dental caries, cheilitis, been paid to the effects of anti-HCV treatment on sialadenitis taste changes, dry mouth, glossitis, glossalgia, perioral or lymphoma development and specific trials are clearly parasthesia, oral pain, oral mucosal damage, oral lichen warranted (2). planus, oral haemorrhage, dry lips and bulla of the lips (2). Dentists should be aware that hyperpigmentation of the Xerostomia tongue can be obtained from the treatment of hepatitis C with Studies have shown that there is an increased incidence interferon-alpha and ribavirin combination therapy (11). of dry mouth in patients with HCV infection, especially those patients on antidepressants, in addition to the known effects Other diseases and variations of normality of HCV on salivary glands. Saliva has many roles including: The exact way HCV infection leads to the development lubrication, cleaning, buffering, remineralisation, moisturising, of lymphoma is not clear but multiple mechanisms have been immunological defence against bacteria and initiation of reported. Two cases of pemphigus vulgaris and paraneoplastic digestion (2). associated with chronic HCV infection and involving the oral Salivary depletion may result in: dental caries, altered cavity have been published. The PV case was supposed to be taste, burning sensation in the mouth, candidiasis, halitosis, caused by IFN therapy but this is a very rare occurrence difficulty chewing, swallowing and talking, difficulty wearing according to the available data. The possibility that Behcet’s dentures, dry mouth and lips, sialadenitis. Salivary flow was disease is an HCV associated disorder was first suggested in reduced in 50 per cent of hepatitis C infected subjects (1). 1995 (3). Leukoplakia was present in 28 cases from 215 patients with chronic hepatitis C (13%). Variations of Oral carcinoma normality were observed in 173 patients (80.5%).
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