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Stacey Jill Sukoff Rizzo Home Addres University of Pittsburgh School of Medicine CURRICULUM VITAE 2020 BIOGRAPHICAL Name: Stacey Jill Sukoff Rizzo Home Address: 2574 Corteland Drive Business Address: 100 Technology Drive Pittsburgh, PA 15241 556 Bridgeside Point I Home Phone: 1-860-772-7522 Pittsburgh, PA 15219 Email: [email protected] Business Phone: 1-412-383-3719 EDUCATION and TRAINING UNDERGRADUATE 1991-1995 Rutgers University, B.S. 1995 Animal Sciences New Brunswick, NJ, USA GRADUATE 2008-2012 University College Ph.D. 2012 Neuroscience London, United Kingdom Advisor: Stephen J. Moss, Ph.D. APPOINTMENTS and POSITIONS ACADEMIC 2019- Present Department of Neurobiology Associate Professor Department of Medicine – Aging Institute University of Pittsburgh Pittsburgh, PA USA Preclinical Phenotyping Core Director University of Pittsburgh Pittsburgh, PA USA NON-ACADEMIC 2014-2019 The Jackson Laboratory Associate Director, Center Bar Harbor, Maine, USA for Biometric Analysis Director, Mouse Neurobehavioral Phenotyping Facility 1 2011-2014 Pfizer Neuroscience Research Principle Research Scientist Cambridge, MA, USA 2010-2011 Pfizer Neuroscience Research Senior Research Scientist Groton, MA, USA 2003-2010 Wyeth Discovery Neuroscience Research Senior Research Scientist Princeton, NJ, USA 2001-2003 Aventis Pharmaceuticals Scientist Bridgewater, NJ, USA 1999-2001 Merck Research Laboratories Staff Biologist San Diego, CA, USA 1996-1999 Wyeth-Ayerst Research Scientist Princeton, NJ, USA 1995-1996 The Wistar Institute Research Technician Philadelphia, PA, USA MEMBERSHIP in PROFESSIONAL and SCIENTIFIC SOCIETIES Society for Neuroscience (SFN) 1996-present New York Academy of Sciences 2007-2010 International Behavioural and Neural Genetics Society (IBANGS) 2014-2016 International Behavioral Neuroscience Society (IBNS) 2015-present HONORS Aventis Achievement Award 2002 Wyeth peer nominated achievement awards 2004,2005,2007 Wyeth Discovery Research Annual Meeting Oral Presentation Award 2005 Wyeth “Research Scientist of the Year” Award 2006 PUBLICATIONS PEER REVIEWED REFEREED ARTICLES 1. Welmaker, G. S., Nelson, J. A., Sabalski, A. L., Potoski, J. R., Graziano, D., Kagan, M., Coupet, J., Dunlop, J., Mazandarani, H., Rosenzweig-Lipson, S., Sukoff, S., and Zhang, Y. Synthesis and 5- Hydroxytryptamine (5-HT) Activity of 2,3,4,4a-Tetrahydro-1H-Pyrazino[1,2-a]Quinoxalin-5- (6H)Ones and 2,3,4,4a,5,6-Hexahydro-1H-Pyrazino[1,2-a]Quinoxalines. Bioorganic & Medicinal Chemistry Letters, 2000, 10(17). 2 2. Brodkin, J., Busse, C., Sukoff, S. J., and Varney, M. A. Anxiolytic-like activity of the mGluR5 antagonist MPEP. A comparison with Diazepam and Buspirone. Pharmacology, Biochemistry, and Behavior, 2002 September; 73 (2): 359-366. 3. Maynard, K. I., Sukoff, S.J., Ji, Z., Wettstein, J.G., and Black, M.D. The acoustic startle reflex in Sprague-Dawley rats is altered by permanent middle cerebral artery occlusion.” Brain Research, 2005, 1032: 44-49. 4. Dunlop J, Sabb AL, Mazandarani H, Zhang J, Kalgaonker S, Shukhina E, Sukoff S, Vogel RL, Stack G, Schechter L, Harrison BL, and Rosenzweig-Lipson S. WAY-163909 ((7bR,10aR)-1,2,3,4,8,9,10,10a- octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole); A Novel 5-HT2C Receptor Selective Agonist with Anorectic Activity. Journal of Pharmacol Exp Ther 2005 May;313(2):862-9. 5. Childers WE Jr., Abou-Gharbia MA, Kelly MG, Andree TH, Harrison BL, Ho DM, Hornby G, Huryn DM, Potestio L, Rosenzweig-Lipson SJ, Schmid J, Smith DL., Sukoff SJ, Zhang G, and Schechter L.E. Synthesis and Biological Evaluation of Benzodioxanylpiperazine Derivatives as Potent Serotonin 5-HT1A Antagonists: The Discovery Lecozatan. J. Med. Chem 2005 May 19; 48(10): 3467-70. 6. Brandt, M.R., Cummons, T., Sukoff, S.J., Potestio, L., and Rosenzweig-Lipson, S. Effects of the NMDA receptor antagonist perzinfotel (EAA-090) on chemically-induced thermal hypersensitivity. Journal of Pharmacology and Experimental Therapeutics 313(3):1379-1386, 2005 Jun. 7. Schechter LE, Smith DL, Rosenzweig-Lipson S, Sukoff SJ, Dawson LA, Marquis K, Jones D, Piesla M, Andree T, Nawoschik S, Harder JA, Womack MD, Buccafusco J, Terry AV, Hoebel B, Rada P, Kelly M, Abou-Gharbia M, Barrett JE, Childers W. Lecozotan (SRA-333): A selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Journal of Pharmacology & Experimental Therapeutics 314(3):1274-1289, 2005 Sep. 8. Ring RH, Malberg JE, Potestio L, Ping J, Boikess S, Luo B, Schechter LE, Rizzo S, Rahman Z, Rosenzweig-Lipson S. Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications. Psychopharmacology 185(2):218-225, 2006 Apr. 9. Rosenzweig-Lipson S, Sabb A, Stack G, Mitchell P, Lucki I, Malberg JE, Grauer S, Brennan J, Cryan JF, Sukoff Rizzo SJ, Dunlop J, Barrett JE, Marquis KL. Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents. Psychopharmacology 192(2):159-170, 2007 Jun. 10. Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender C, Nieuwenhuijsen BW, Ring RH, Rosenzweig-Lipson S, Beyer CE. Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon. Neuropeptides 41(5):307-320, 2007 Oct. 11. Malberg J, Platt B, Sukoff Rizzo SJ, Lucki I, Schechter L, Rosenzweig-Lipson S. Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects. Neuropsychopharmacology 32(11):2360-2368, 2007 Nov. 12. Sukoff Rizzo SJ, Schechter LE, Rosenzweig-Lipson S. A novel approach for predicting antidepressant-induced sexual dysfunction in rats. Psychopharmacology 195(4):459-467, 2008 Jan. 13. Leonard SK, Dwyer JM, Sukoff Rizzo SJ, Platt B, Logue SF, Neal SJ, Malberg JE, Beyer CE, Schechter LE, Rosenzweig-Lipson S, Ring, RH. Pharmacology of Neuropeptide S in mice: therapeutic relevance to anxiety disorders. Psychopharmacology 197(4):601-11, 2008 May. 3 14. Dwyer JM, Rizzo SJ, Neal SJ, Lin Q, Jow F, Arias RL, Rosenzweig-Lipson S, Dunlop J, Beyer CE. Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models. Psychopharmacology (Berl). 2009 Mar;203(1):41-52. 15. Sukoff Rizzo SJ, Pulicicchio C, Malberg JE, Andree TH, Stack GP, Hughes ZA, Schechter LE, Rosenzweig-Lipson S. 5-HT1A receptor antagonism reverses and prevents fluoxetine-induced sexual dysfunction in rats. Int J Neuropsychopharmacol. 2009 Sep;12(8):1045-53. 16. Ring RH, Schechter LE, Leonard SK, Dwyer JM, Platt BJ, Graf R, Grauer S, Pulicicchio C, Resnick L, Rahman Z, Sukoff Rizzo SJ, Luo B, Beyer CE, Logue SF, Marquis KL, Hughes ZA, Rosenzweig-Lipson S. Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist. Neuropharmacology. 2010 Jan;58(1):69-77. 17. Kelly MP, Logue SF, Brennan J, Day JP, Lakkaraju S, Jiang L, Zhong X, Tam M, Sukoff Rizzo SJ, Platt BJ, Dwyer JM, Neal S, Pulito VL, Agostino MJ, Grauer SM, Navarra RL, Kelley C, Comery TA, Murrills RJ, Houslay MD, Brandon NJ. Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8457-62. 18. Childers WE Jr, Havran LM, Asselin M, Bicksler JJ, Chong DC, Grosu GT, Shen Z, Abou-Gharbia MA, Bach AC 3rd, Harrison BL, Kagan N, Kleintop T, Magolda R, Marathias V, Robichaud AJ, Sabb AL, Zhang MY, Andree TH, Aschmies SH, Beyer C, Comery TA, Day M, Grauer SM, Hughes ZA, Rosenzweig-Lipson S, Platt B, Pulicicchio C, Smith DE, Sukoff-Rizzo SJ, Sullivan KM, Adedoyin A, Huselton C, Hirst WD. The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists. J Med Chem. 2010 May 27;53(10):4066-84. 19. Dwyer JM, Platt BJ, Rizzo SJ, Pulicicchio CM, Wantuch C, Zhang MY, Cummons T, Leventhal L, Bender CN, Zhang J, Kowal D, Lu S, Rajarao SJ, Smith DL, Shilling AD, Wang J, Butera J, Resnick L, Rosenzweig-Lipson S, Schechter LE, Beyer CE. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. Int J Neuropsychopharmacol. 2010 Oct;13(9):1193-205. 20. Gilbert AM, Bursavich MG, Lombardi S, Adedoyin A, Dwyer JM, Hughes Z, Kern JC, Khawaja X, Rosenzweig-Lipson S, Moore WJ, Neal SJ, Olsen M, Rizzo SJ, Springer D. 3-(Pyridin-2-yl- ethynyl)benzamide metabotropic glutamate receptor 5 negative allosteric modulators: hit to lead studies. Bioorg Med Chem Lett. 2011 Jan 1;21(1):195-9. 21. Sukoff Rizzo SJ, Leonard SK, Gilbert A, Dollings P, Smith DL, Zhang MY, Di L, Platt BJ, Neal S, Dwyer JM, Bender CN, Zhang J, Lock T, Kowal D, Kramer A, Randall A, Huselton C, Vishwanathan K, Tse SY, Butera J, Ring RH, Rosenzweig-Lipson S, Hughes ZA, Dunlop J. The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? J Pharmacol Exp Ther. 2011 Jul;338(1):345-52. 22. Hughes ZA, Neal SJ, Smith DL, Sukoff Rizzo SJ, Pulicicchio CM, Lotarski S, Lu S, Dwyer JM, Brennan J, Olsen M, Bender CN, Kouranova E, Andree TH, Harrison JE, Whiteside GT, Springer D, O'Neil SV, Leonard SK, Schechter LE, Dunlop J, Rosenzweig-Lipson S, Ring RH. Negative allosteric modulation of metabolic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression. Neuropharmacology. 2013; 66:202-14. 23. Silverman JL, Smith DG, Rizzo SJ, Karras MN, Turner SM, Tolu SS, Bryce DK, Smith DL, Fonseca K, Ring RH, Crawley JN. Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. Sci Transl Med. 2012 Apr 25;4(131):131ra51. 4 24. Sukoff Rizzo SJ, Neal SJ, Hughes ZA, Beyna M, Rosenzweig-Lipson S, Brandon NJ, and Moss SJ. Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes.
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