Anti-TCF7L1 Monoclonal Antibody, Clone FQS3142 (DCABH-2698) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-TCF7L1 monoclonal antibody, clone FQS3142 (DCABH-2698) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit monoclonal to TCF7L1

Antigen Description Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.

Immunogen Synthetic peptide corresponding to residues in Human TCF7L1 (UniProt Q9HCS4).

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Clone FQS3142

Purity Tissue culture supernatant

Conjugate Unconjugated

Applications WB, Flow Cyt

Positive Control A431 and Human fetal small intestine lysates

Format Liquid

Size 100 μl

Buffer pH: 7.40; Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA

Preservative 0.01% Sodium Azide

Storage Store at -20°C. Stable for 12 months at -20°C

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol TCF7L1

Synonyms TCF7L1; transcription factor 7-like 1 (T-cell specific, HMG-box); TCF3; transcription factor 7-like 1; HMG box transcription factor 3; TCF-3;

Entrez Gene ID 83439

Protein Refseq NP_112573

UniProt ID Q9HCS4

Chromosome Location 2p11.2

Pathway Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Basal cell carcinoma, organism-specific biosystem;

Function DNA binding; beta-catenin binding; chromatin binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]