Anti-TCF7L1 monoclonal antibody, clone FQS3142 (DCABH-2698) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Rabbit monoclonal to TCF7L1 Antigen Description Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. Immunogen Synthetic peptide corresponding to residues in Human TCF7L1 (UniProt Q9HCS4). Isotype IgG Source/Host Rabbit Species Reactivity Human Clone FQS3142 Purity Tissue culture supernatant Conjugate Unconjugated Applications WB, Flow Cyt Positive Control A431 and Human fetal small intestine lysates Format Liquid Size 100 μl Buffer pH: 7.40; Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA Preservative 0.01% Sodium Azide Storage Store at -20°C. Stable for 12 months at -20°C GENE INFORMATION 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Gene Name TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) [ Homo sapiens ] Official Symbol TCF7L1 Synonyms TCF7L1; transcription factor 7-like 1 (T-cell specific, HMG-box); TCF3; transcription factor 7-like 1; HMG box transcription factor 3; TCF-3; Entrez Gene ID 83439 Protein Refseq NP_112573 UniProt ID Q9HCS4 Chromosome Location 2p11.2 Pathway Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Basal cell carcinoma, organism-specific biosystem; Function DNA binding; beta-catenin binding; chromatin binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.