Planta Medica Journal of Medicinal Plant and Natural Product Research
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www.thieme.de/fz/plantamedica l www.thieme-connect.com/ejournals Planta Medica Journal of Medicinal Plant and Natural Product Research Editor-in-Chief Advisory Board Publishers Luc Pieters, Antwerp, Belgium Georg Thieme Verlag KG John T. Arnason, Ottawa, Canada Stuttgart · New York Yoshinori Asakawa, Tokushima, Japan Rüdigerstraße 14 Senior Editor Lars Bohlin, Uppsala, Sweden D-70469 Stuttgart Adolf Nahrstedt, Münster, Germany Mark S. Butler, S. Lucia, Australia Postfach 30 11 20 João Batista Calixto, Florianopolis, Brazil D-70451 Stuttgart Claus Cornett, Copenhagen, Denmark Review Editor Hartmut Derendorf, Gainesville, USA Thieme Publishers Matthias Hamburger, Basel, Switzerland Alfonso Garcia-Piñeres, Frederick MD, USA 333 Seventh Avenue Jürg Gertsch, Zürich, Switzerland New York, NY 10001, USA Simon Gibbons, London, UK www.thieme.com Editors De-An Guo, Shanghai, China Rudolf Bauer, Graz, Austria Andreas Hensel, Münster, Germany Veronika Butterweck, Muttenz, Kurt Hostettmann, Geneva, Switzerland Switzerland Peter J. Houghton, London, UK Thomas Efferth, Mainz, Germany Ikhlas Khan, Oxford MS, USA Irmgard Merfort, Freiburg, Germany Jinwoong Kim, Seoul, Korea Hermann Stuppner, Innsbruck, Austria Wolfgang Kreis, Erlangen, Germany Yang-Chang Wu, Taichung, Taiwan Roberto Maffei Facino, Milan, Italy Andrew Marston, Bloemfontein, South Africa Editorial Offices Matthias Melzig, Berlin, Germany Claudia Schärer, Basel, Switzerland Eduardo Munoz, Cordoba, Spain Tess De Bruyne, Antwerp, Belgium Nicholas H. Oberlies, Greensboro NC, USA Nigel B. Perry, Dunedin, New Zealand Joseph Pfeilschifter, Frankfurt, Germany Peter Proksch, Düsseldorf, Germany Jose-Luis Rios, Valencia, Spain Kurt Schmidt, Graz, Austria Thomas Schmidt, Münster, Germany Thomas Simmet, Ulm, Germany Leandros Skaltsounis, Athens, Greece Han-Dong Sun, Kunming, China Ping-Jyun Sung, Pingtung, Taiwan Deniz Tasdemir, Galway, Ireland Arnold Vlietinck, Antwerp, Belgium Günther Vollmer, Dresden, Germany Heikki Vuorela, Helsinki, Finland Jean-Luc Wolfender, Geneva, Switzerland Yang Ye, Shanghai, China www.thieme-connect.de/ejournals | www.thieme.de/fz/plantamedica Planta Medica July 2012 · Page 1027 – 1310 · Volume 78 11 · 2012 1027 Editorial 1114 Topic F: Herbal Products/Botanicals: Ethnobotanical Approaches 1134 Topic G: Innovative Approaches – Misc. 1028 Invited Lectures 1137 Topic H: Metabolism, PK and Safety 1143 Topic I: Natural Products Discovery: Marine, Microbes, 1044 Contributed Lectures Plants and other 1249 Topic J: Natural Products Technology: Analytical 1062 Award Lectures Chemistry, Isolation/Chromatography, Structure De- termination and other 1283 Topic K: Synthetic Approaches 1064 Poster 1286 Topic L: Other 1064 Topic A: Biodiversity 1067 Topic B: Biosynthesis 1293 Authors’ Index 1070 Topic C: Chemical Ecology/Symbiosis 1072 Topic D: Drug Discovery: Medicinal Chemistry, Pharmacology, Screening and other III Masthead 1112 Topic E: Genomic Approaches " Cover picture: New York midtown skyline over the Hudson River, Ó Fotosearch.com Editorial 1027 2012 International Congress on Natural Products Research “Global Change, Natural Products and Human Health” Date/Location: July 28 – August 1, 2012, New York City Chairmen: Guy T. Carter, Scientific Organizing Committee Edward Kennelly, Local Organizing Committee Issue Editor: Mark O’Neil-Johnson Dear Colleagues, ICNPR 2012, the 8th joint meeting sponsored by the American Society of Pharmacognosy (ASP), and ]sister societies from Europe: the Italian Society of Pharmacognosy (SIF), the Society for Medicinal Plant and Natural Products Research (GA), the Phytochemical Society of Europe (PSE) and the French Speaking Society of Pharmacognosy (AFERP), has been organized this year in New York. As Chairs of the Local and Scientific Organizing Committees, it is our pleasure to welcome you to New York. We are delighted by the response that was forthcoming for contributions to this Congress. We received nearly 1300 abstracts from scientists representing 64 countries from across the globe. The master plan for our scientific program includes plenary sessions each morning of the Congress primarily dedicated to prestigious Award lectures and a celebration of the publication of the 75th Volume of the Journal of Natural Products. Except for Sunday these lectures are followed by parallel symposia dedicated to specialized areas of natural products research. The afternoons are devoted to contributed papers, with oral sessions launched by prominent scientists followed by extensive poster sessions arranged by topic areas. Sunday afternoon features a visit to the New York Botanical Garden for a chance to see the extensive collection in a relaxed and unhurried private showing. The scientific program remains faithful to the traditional areas of interest to the sponsoring Societies, natural products discovery and analyses, while providing glimpses into specialized areas with strong natural products connections: Chemistry of Symbiosis, Genome Mining and Drug Discovery. We would like to thank all of the members of the Local and Scientific Organizing Committees (listed below), for their enthusiastic contributions. We are particularly indebted to Dr. Mark O'Neil-Johnson for his efforts in gathering and editing these abstracts, which provide a foundation for the scientific discourse that will unfold during this Congress. Edward Kennelly Chair, Local Organizing Committee Guy T. Carter Chair, Scientific Organizing Committee Planta Med 2012; 78: 1027–1310 Georg Thieme Verlag KG Stuttgart · New York · ISSN 0032-0943 1028 Abstracts | 8th Joint Meeting of AFERP, ASP, GA, PSE & SIF | July 28 – August 1, 2012, New York City Invited Lectures Biodiversity of marine invertebrates, the benefits from their “biodiscovery” and how much do we Chemical diversity in the plant world: Why can’t IL3 still not know? we find more plant derived drugs? Hooper JNA IL1 Miller JS Biodiversity & Geosciences Programs, Queensland Museum, The New York Botanical Garden, 200 Southern Blvd., Bronx, PO Box 3300, South Brisbane, QLD 4101 Australia and Eskitis NY 10458, U.S.A. Institute for Cell & Molecular Therapies, Griffith University The natural world has long been a rich source of medicinally useful While only about 50% of all new approved drugs were derived directly compounds, yet many large scale discovery efforts in the later part of from natural sources over the past 30 years, natural products (NPs) the 20th century yielded far fewer useful discoveries than had been continue to deliver unique structural diversity, with marine inverte- anticipated. At the same time, only a small percentage of plant species brates being a significant source of these (as evidenced by ~10,000 NPs have been evaluated against a limited number of possible therapeutic discovered from marine invertebrates over this period). However, it has targets. The scope of plant diversity is reviewed and it is estimated that been estimated that these discoveries come from less than 10% of the there are perhaps close to 400,000 species of plants. Study of a small world’s (metazoan) biodiversity, and therefore many more useful natur- percentage of these species have yielded more than 100 medically useful al lead compounds predictably await discovery. This is the ’Promise of compounds. Extrapolating from the numbers of plant species that were Biodiversity’, but how do we know it has any credence, what is the scope likely studied to discover these compounds it is concluded that there are and distribution of the major constituent taxa, how well do we know at least 500, and possibly many more, medically useful novel biochem- these, and what threatens their existence – and hence the validity of this ical compounds that remain to be discovered in plants. The reasons that promise as a source for new bioactivity discoveries as potential sources efforts of the late 20th century were not more successful are reviewed of new drugs (marine genetic resources, or MGRs)? This presentation and possible alternative approaches suggested. gives an overview of the major groups of marine invertebrates that have shown most bioactivity (basal metazoan, eumetazoan and deuterostome bilaterians), and uses some local examples of new NPs that have also Biological and chemical diversity among revealed substantial new knowledge about marine invertebrate species. rainforest endophytes The scope of marine species diversity in both taxonomic and geographic IL2 Strobel SA spaces shows unequivocally huge potential, but currently faces equally Department of Molecular Biophysics and Biochemistry, Yale huge challenges under the shadow of the ’taxonomic impediment’. This University, New Haven, CT 06520 impediment includes the competing goals of achieving better, more substantial knowledge of these taxa and their unique chemical profiles, Biological and chemical diversity is an accessible entry point for novice versus the diminishing taxonomic expertise capable of achieving this, students to make original observations about the natural world and to the natural and anthropogenically induced threats facing the survival of become engaged in the excitement of the scientific process. For the past this biodiversity, and further exacerbated by the "uncertainty principle" six years we have taught the course Rainforest Expedition and Labora- that highlights the great divide between the presently ’known’, the cur- tory (REAL) with the goal of providing an inquiry-based educational rently ’unknown’, and the ’unknowable’ (the latter highly technologi- program that gives