DOCSLIB.ORG

Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis Journal of Diabetes Research Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis Guest Editors: Shirong Zheng, David W. Powell, Feng Zheng, Phillip Kantharidis, and Luigi Gnudi Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis Journal of Diabetes Research Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis Guest Editors: Shirong Zheng, David W.Powell, Feng Zheng, Phillip Kantharidis, and Luigi Gnudi Copyright © 2016 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Journal of Diabetes Research.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Steven F Abcouwer, USA Thomas Haak, Germany Ulrike Rothe, Germany Reza Abdi, USA Thomas J. Hawke, Canada Toralph Ruge, Sweden Abdelaziz Amrani, Canada Ole Kristian Hejlesen, Denmark Christoph H. Saely, Austria Giovanni Annuzzi, Italy Dario Iafusco, Italy Ponnusamy Saravanan, UK Jean L. Ardilouze, Canada Konstantinos Kantartzis, Germany Toshiyasu Sasaoka, Japan Evan Atlantis, Australia Daisuke Koya, Japan Andrea Scaramuzza, Italy Fabrizio Barbetti, Italy Frida Leonetti, Italy Yael Segev, Israel Irene D. Blackberry, Australia Sandra MacRury, UK Suat Simsek, Netherlands Simona Bo, Italy Afshan Malik, UK Eirik Søfteland, Norway Sihem Boudina, USA Roberto Mallone, France Marco Songini, Italy NormandG.Boulé,Canada Raffaele Marfella, Italy Harald Sourij, Austria Monica Bullo, Spain Carlos Martinez Salgado, Spain Janet H. Southerland, USA Stefania Camastra, Italy Lucy Marzban, Canada Kimber Stanhope, USA Norman Cameron, UK Raffaella Mastrocola, Italy David Strain, UK Ilaria Campesi, Italy David Meyre, Canada Kiyoshi Suzuma, Japan Riccardo Candido, Italy Maria G. Montez, USA Giovanni Targher, Italy Brunella Capaldo, Italy Stephan Morbach, Germany Patrizio Tatti, Italy Danila Capoccia, Italy Jiro Nakamura, Japan Farook Thameem, USA Sergiu Catrina, Sweden Monica Nannipieri, Italy Michael J. Theodorakis, UK Subrata Chakrabarti, Canada Pratibha V. Nerurkar, USA Peter Thule, USA Munmun Chattopadhyay, USA Monika A. Niewczas, USA Ronald G. Tilton, USA Eusebio Chiefari, Italy Mitsuhiko Noda, Japan Andrea Tura, Italy Secundino Cigarran, Spain Francisco Javier Nóvoa, Spain Ruben Varela-Calvino, Spain Kim Connelly, Canada Craig S. Nunemaker, USA Christian Wadsack, Austria Laurent Crenier, Belgium Hiroshi Okamoto, Japan Matthias Weck, Germany Christophe De Block, Belgium Ike S. Okosun, USA Geoff Werstuck, Canada Devon A. Dobrosielski, USA Fernando Ovalle, USA Per Westermark, Sweden Francesco Dotta, Italy Jun Panee, USA Jennifer Wilkinson-Berka, Australia Khalid M. Elased, USA Cesare Patrone, Sweden Dane K. Wukich, USA Ulf J. Eriksson, Sweden Subramaniam Pennathur, USA Daisuke Yabe, Japan Paolo Fiorina, USA Marcus Pezzolesi, USA Kazuya Yamagata, Japan Andrea Flex, Italy Andreas Pfützner, Germany Shi Fang Yan, USA Daniela Foti, Italy Rodica Pop-Busui, USA Mark A. Yorek, USA Georgia Fousteri, Italy Bernard Portha, France Liping Yu, USA Maria Pia Francescato, Italy Ed Randell, Canada David Zangen, Israel Pedro M. Geraldes, Canada Jordi Lluis Reverter, Spain Thomas J. Zgonis, USA Margalit D. Goldfracht, Israel Ute Christine Rogner, France Dan Ziegler, Germany Contents Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis Shirong Zheng, David W. Powell, Feng Zheng, Phillip Kantharidis, and Luigi Gnudi Volume 2016, Article ID 5241549, 2 pages Influence of Acute High Glucose on Protein Abundance Changes in Murine Glomerular Mesangial Cells Michelle T. Barati, James C. Gould, Sarah A. Salyer, Susan Isaacs, Daniel W. Wilkey, and Michael L. Merchant Volume 2016, Article ID 3537863, 11 pages Immune Cells and Inflammation in Diabetic Nephropathy Zihan Zheng and Feng Zheng Volume 2016, Article ID 1841690, 10 pages Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice Shirong Zheng, Susan Coventry, Lu Cai, David W. Powell, Venkatakrishna R. Jala, Bodduluri Haribabu, and Paul N. Epstein Volume 2016, Article ID 5362506, 11 pages A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications Francesca Conserva, Loreto Gesualdo, and Massimo Papale Volume 2016, Article ID 7934504, 23 pages Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus Caroline Pereira Domingueti, Rodrigo Bastos Fóscolo, Janice Sepúlveda Reis, Fernanda Magalhães Freire Campos, Luci Maria S. Dusse, Maria das Graças Carvalho, Karina Braga Gomes, and Ana Paula Fernandes Volume 2016, Article ID 2315260, 8 pages Review of Herbal Traditional Chinese Medicine for the Treatment of Diabetic Nephropathy Guang-dong Sun, Chao-yuan Li, Wen-peng Cui, Qiao-yan Guo, Chang-qing Dong, Hong-bin Zou, Shu-jun Liu, Wen-peng Dong, and Li-ning Miao Volume 2016, Article ID 5749857, 18 pages Hindawi Publishing Corporation Journal of Diabetes Research Volume 2016, Article ID 5241549, 2 pages http://dx.doi.org/10.1155/2016/5241549 Editorial Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis Shirong Zheng,1 David W. Powell,2 Feng Zheng,3 Phillip Kantharidis,4 and Luigi Gnudi5 1 Department of Cardiovascular and Thoracic Surgery, Cardiovascular Innovation Institute, University of Louisville, Louisville, KY 40202, USA 2Department of Medicine and Division of Nephrology and Hypertension, School of Medicine, University of Louisville, Louisville, KY 40202, USA 3Department of Nephrology, The Second Hospital and Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China 4JDRF Danielle Alberti Memorial Centre for Diabetes Complications, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia 5Cardiovascular Division, School of Life Science & Medicine, King’s College London, Department of Diabetes and Endocrinology, Guy’s Hospital, London SE1 9RT, UK Correspondence should be addressed to Shirong Zheng; [email protected] Received 17 December 2015; Accepted 17 December 2015 Copyright © 2016 Shirong Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Diabetic nephropathy (DN) is a serious complication of dia- the renal expression of decoy chemokine receptor ACKR2 betes; it initially manifests with microalbuminuria and pro- in DN patients and renal protection in diabetic mice with gresses towards end-stage renal failure. Sustained diabetes- ACKR2 gene knockout, revealing the unexpected negative related metabolic and haemodynamic perturbations can role of ACKR2 in diabetic kidney disease. Association of induce subclinical low-grade renal inflammation and drive haemostatic and inflammatory biomarkers with nephropathy kidney from repair response to damage process, eventually in type I diabetic patients is shown by C. P.Domingueti et al., torenalfibrosis.Inthisspecialissue,weincludearticles indicating potential therapeutic targets for DN. regarding inflammation, Chinese herbs, and systems biol- ogy to present up-to-date information on immune cells, (2) Chinese Medicine. Herbs are major form of therapy in chemokine receptor, and biomarkers in DN, displaying com- traditional Chinese medicine. Their value has been illustrated bined therapy in treatment of DN and highlighting the by the discovery of artemisinin [1], a drug saving millions effective approach in exploring genetic susceptibility of DN. of lives from malaria, derived from an active ingredient of Chinese herb. Chinese medicine is part of the treatment used (1) Inflammation. Despite the broad themes covered by this againstDNinChina.InreviewbyG.Sunetal.,over20recipes special issue, all articles focus on a common theme: immune of herb medicine and 30 single herbs or monomers are sum- cells and inflammation. Hyperglycemia and oxidative stress, marized. These therapies have showed efficacy at improving as well as albuminuria per se, can lead the immune and albuminuria and inflammation in diabetic patients. Ongoing inflammatory cells to infiltrate into kidney and release proin- research programs focus on identifying the effective com- flammatory cytokines. This inflammatory “repair process” ponent(s) contained in the most promising herbs with the revertstoandmanifestsasa“chronicunfavorableprocess” ultimate aim of developing safe and novel compounds for the that eventually leads to the disease phenotype (renal fibrosis). treatment of DN. ThereviewarticlebyZ.ZhengandF.Zhengsummarizesthe role of immune cells and inflammation in DN, highlighting (3) Systems Biology. As defined by NIH, systems biology the contribution of APC cells, T-helper cells, and tubular is an approach used in biomedical research to understand epithelial cells to the inflammation. S. Zheng et al. reported the “bigger picture”—be it at the level of the organism, 2 Journal of Diabetes Research tissue, or cell—to reconstruct the biology from huge volumes data using computational and mathematical methods. This is in stark contrast to decades of reductionist biology, which involved taking the pieces apart in order to understand the biology [2]. As technology advances, genomics, proteomics, and metabolomics become reliable, affordable, and readily available to explore the molecular profiles of human disease.
Load more

Recommended publications
  • Thirty-Third Sunday in Ordinary Time NOVEMBER 15 2020
    Thirty-third Sunday in ordinary time NOVEMBER 15 2020 WELCOME Mass AT T H E CAT H E D R A L Daily 12:05pm and Sunday Masses have resumed. All Masses are limited capacity. 7am Daily Masses have NOT resumed. Saturday, Nov 14 12:05pm Daily Mass—Church † Donald & Mary Lintner 4:30pm Sunday Vigil Mass—Church † Elmer & Mildred Lintner Sunday, Nov 15 10:00am Sunday Mass—Church (televised|live‐streamed) ALS Interpretaon † Ted Hauser 12:00pm Misa Dominical en Español—Iglesia Familia Parroquial 5:30pm Sunday Mass—Church † Sam Macaluso 7:30pm Sunday Contemplave Mass—Church † Fr. Dennis Morrow Monday, Nov 16 12:05pm Daily Mass—Church † James Philips Oleck Tuesday, Nov 17 12:05pm Daily Mass—Church Int. Gabriela Cochrane Wednesday, Nov 18 12:05pm Daily Mass—Church Int. Orlando & Enid Benedict Thursday, Nov 19 12:05pm Daily Mass—Church Int. Andrea Creswick Friday, Nov 20 12:05pm Daily Mass—Church Int. Novakoski family Saturday, Nov 21 12:05pm Daily Mass—Church 4:30pm Sunday Vigil Mass—Church † Joseph & Catherine Wojkowski Sunday, Nov 22 10:00am Sunday Mass—Church (televised|live‐streamed) ALS Interpretaon † Don Jandernoa 12:00pm Misa Dominical en Español—Iglesia Familia Parroquial 5:30pm Sunday Mass—Church † Samantha Pas 7:30pm Sunday Contemplave Mass—Church † Michael Monica & † Gregory Monica Confession schedule: Weekdays Confessions follow 12:05pm Mass Saturdays Confessions 11‐11:45am in Chapel God bless, (or by appointment) Very Rev. René Constanza, CSP Rector Watch Sunday 10am Mass Online page 2 Go to grdiocese.org or the Cathedral’s Facebook page Scripture Reading..
    [Show full text]
  • Recovery from Disorders of Consciousness: Mechanisms, Prognosis and Emerging Therapies
    REVIEWS Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies Brian L. Edlow 1,2, Jan Claassen3, Nicholas D. Schiff4 and David M. Greer 5 ✉ Abstract | Substantial progress has been made over the past two decades in detecting, predicting and promoting recovery of consciousness in patients with disorders of consciousness (DoC) caused by severe brain injuries. Advanced neuroimaging and electrophysiological techniques have revealed new insights into the biological mechanisms underlying recovery of consciousness and have enabled the identification of preserved brain networks in patients who seem unresponsive, thus raising hope for more accurate diagnosis and prognosis. Emerging evidence suggests that covert consciousness, or cognitive motor dissociation (CMD), is present in up to 15–20% of patients with DoC and that detection of CMD in the intensive care unit can predict functional recovery at 1 year post injury. Although fundamental questions remain about which patients with DoC have the potential for recovery, novel pharmacological and electrophysiological therapies have shown the potential to reactivate injured neural networks and promote re-emergence of consciousness. In this Review, we focus on mechanisms of recovery from DoC in the acute and subacute-to-chronic stages, and we discuss recent progress in detecting and predicting recovery of consciousness. We also describe the developments in pharmacological and electro- physiological therapies that are creating new opportunities to improve the lives of patients with DoC. Disorders of consciousness (DoC) are characterized In this Review, we discuss mechanisms of recovery by alterations in arousal and/or awareness, and com- from DoC and prognostication of outcome, as well as 1Center for Neurotechnology mon causes of DoC include cardiac arrest, traumatic emerging treatments for patients along the entire tempo- and Neurorecovery, brain injury (TBI), intracerebral haemorrhage and ral continuum of DoC.
    [Show full text]
  • Sharyn Gersh for Every Project We Do
    "There's a reason we keep going back to Sharyn Gersh for every project we do. SHARYN GERSH She's the best music editor in the business. Her creativity, speed, and I-can-make-this-work attitude have made her invaluable to us. President/CEO We can't imagine working with anyone else." Co-Owner -- Michelle & Robert King, Creator-Exec Producers of The Good Fight & The Good Wife AWARDS 2016 Golden Reel Award Best Sound Editing In Television Long Form Music: “Teen Beach 2” 2012 Golden Reel Award Best Sound Editing In Television Episodic Music: “Raising Hope: Prodigy” 2003 Golden Reel Award [email protected] Best Sound Editing In Television Episodic Music: “American Dreams: Cold Snap” 2001 Emmy Outstanding Sound Editing For A Series: 818-730-6973 “ER: The Crossing” 2001 Golden Reel Award Best Sound Editing In Television Episodic Music: “Ally McBeal: The Musical, Almost” www.createharmonymedia.com 1999 Emmy Outstanding Sound Editing For A Series: “ER: The Storm, Pt 2” (for full list of nominations go to IMDB: Sharyn Gersh, Sharyn Tylk-Gersh) Billing Address: 1837 N Niagara St SELECTED PROJECTS Burbank, CA 91505 Titles Composers “Evil” David Buckley “Dare Me” Jonathan Sanford “The Good Fight” David Buckley Office Address: “Whiskey Cavalier” Harry Gregson-Williams 1119 S. Flower St “American Woman” John Swihart Burbank, CA 91506 “Trial & Error” John Swihart “Life Sentence” Waz & Jamie Jackson “Youth & Consequences” Waz & Jamie Jackson “Braindead” David Buckley “The Good Wife” David Buckley fb.me/CreateHarmonyMedia “Kingdom” Tyler Bates “Betrayal” BT “Harry’s Law” Transcenders “Playboy Club” David Schwartz & Transcenders linkedin.com/in/sharyn-gersh “Raising Hope” Danny Lux & Matt Moriano linkedin.com/company/createharmony “Terriers” Robert Duncan “ER” Marty Davich “My Name Is Earl” Danny Lux “Ally McBeal” Danny Lux “The Practice” Stewart Levin (for full list of credits go to IMDB: Sharyn Gersh, Sharyn Tylk-Gersh) .
    [Show full text]
  • A8 TV TUESDAY [8-8].Indd
    8B TIMES-TRIBUNE / TUESDAY, APRIL 3, 2012 OF INTEREST/ENTERTAINMENT TUESDAY PRIME TIME APRIL 3, 2012 6:00 6:30 7:00 7:30 8:00 8:30 9:00 9:30 10:00 10:30 11:00 11:30 Local students attend BROADCAST ABC & WATE 6 ABC World News & Judge Judy & Judge Last Man Stand- (:31) Cougar Dancing With the Stars (N) ’ (:01) Body of Proof “Going Viral” & WATE 6 (:35) Nightline News at 6 With Diane Saw- D Entertain- Judy Å ing (N) ’ Å Town (N) ’ Å (Live) Å Searching for the source of the virus. News at 11 (N) Å WATE & D ABC 36 yer (N) Å ment Tonight D The Insider (N) ’ (Part 2 of 2) Å D ABC 36 WTVQ D News at 6 (N) Å News at 11 state 4-H Teen Summit CBS Y News CBS Evening Y Simply the Y The King of NCIS “Engaged, Part 1” The team NCIS: Los Angeles “Sacrifice” A drug Unforgettable “Lost Things” A public Y 57 Mountain (:35) Late Show ( Local 8 News News With Scott Law Queens investigates a plane crash. ’ (Part 1 cartel linked a terrorist. ’ Å (DVS) defender is murdered. ’ Å News With David Let- WYMT Y ; Newsfirst at Pelley (N) ’ Å ( Entertain- ( The Andy of 2) Å (DVS) ( WVLT Local terman (N) ’ Å WVLT ( 6:00pm ment Tonight Griffith Show 8 News WKYT ; ; Wheel of ; Jeopardy! ; 27 Newsfirst Fortune (N) NBC 2 LEX 18 News NBC Nightly 2 LEX 18 2 Access Hol- The Biggest Loser The contestants The Voice “Live Results, 4 Go Home” Fashion Star “High-End Appeal; 2 LEX 18 News (:35) The Tonight at 6 (N) Å News (N) ’ Å NEWS lywood receive makeovers.
    [Show full text]
  • RAISING HOPE "Shelley's in Love."
    RAISING HOPE "Shelley's In Love." Written by Jennifer Rose Bellis 566 1/2 W Brady Street. Butler, PA 16001 (724) 679 7900 [email protected] ACT ONE FADE IN: INT. HOWDY’S MARKET - EVENING FRANK and JIMMY stand by the Deli case. JIMMY You should come over tonight. Sabrina is going to Shelley’s for a girl’s night. FRANK Sorry, Dude. Can’t tonight. I’m busy. JIMMY What do you have “hot date”? FRANK Nah, Man. I’m helping my Uncle out with something. JIMMY Okay, some other time then. Jimmy and Frank close up the store. CUT TO: INT. SHELLEY’S APARTMENT - BEDROOM - NIGHT SHELLEY sits in front of her computer wearing a horse mask. On the screen, a man in a baby face mask. SHELLEY I can’t wait till tomorrow. BABY FACE I hope you not an ugo. Shelley laughs. The doorbell RINGS. 2 SHELLEY I have to go. I’ll see you tomorrow. BABY FACE Bye. Shelley leaves the room and makes her way to the door. INT. SHELLEY’S APARTMENT - LIVING ROOM - MOMENTS LATER Shelley answers the door. SABRINA comes in. SHELLEY I’m glad you could come over. I have big news. SABRINA What’s the big news? SHELLEY I’m finally going to meet Baby Face. SABRINA The weird guy that you have been talking to online. SHELLEY Yeah. We are going to meet tomorrow night. Sabrina sits on the couch. Shelley goes to the kitchen and brings back Marguerites. She hands one to Sabrina and sits on the chair beside the couch.
    [Show full text]
  • Pastor of Northern Virginia Mission Church Reflects on 15 Years Of
    Pastor of northern Virginia mission church reflects on 15 years of raising hope for the ‘least of these’ n1995, after nearly two decades of prostitutes and sinners into his working with Sojourners and the inner circle. When criticized for Iinner-city poor of Washington, D.C., eating with them, he replied, “It Bishop Tom Stockton appointed me to is not the healthy who need a explore starting a church among the doctor, but the sick. But go and poor and marginalized living along the learn what this means: ‘I desire Route One Corridor south of Alexan- mercy, not sacrifice.’ For I have dria. In June 1996, Doug Dillard, the not come to call the righteous, Alexandria District superintendent, and but sinners” (Matthew 9:12-12). I chartered a new congregation in the If Jesus invited the most dis- community room of the West Ford pub- reputable members of society to lic housing project. We had 11 members become his disciples, can we do and named this congregation Rising any less? The gospel is both chal- Hope United Methodist Mission Church. lenging and life-changing. Our mission has always been to bring the power of Christ and the support of the church to the least, the lost, the lone- (Above, L-R) Aceline Bapthelus, ly and the left out of our community. As Deborah Johnson and Dwayne a result we have drawn our membership Sands prepare meals for the from the many homeless, formerly home- impoverished. (Left, L-R) Mauri less, disabled and working poor members Bishop (Wesley Seminary of our community as well as a number of student) assists Pastor Keary middle-class families called to serve God Kincannon in serving Holy among the least of these.
    [Show full text]
  • 2010 Annual Report
    2010 ANNUAL REPORT Table of Contents Letter from the President & CEO ......................................................................................................................5 About The Paley Center for Media ................................................................................................................... 7 Board Lists Board of Trustees ........................................................................................................................................8 Los Angeles Board of Governors ................................................................................................................ 10 Media Council Board of Governors ..............................................................................................................12 Public Programs Media As Community Events ......................................................................................................................14 INSIDEMEDIA Events .................................................................................................................................14 PALEYDOCFEST ......................................................................................................................................20 PALEYFEST: Fall TV Preview Parties ...........................................................................................................21 PALEYFEST: William S. Paley Television Festival ......................................................................................... 22 Robert M.
    [Show full text]
  • 715-479-5752 • Siding Garages • Plumbing • Electrical • Heavy Equipment Operation • Roofing Remodeling • Roofing DAN’S DOCK 2255 Hwy
    PAID ECRWSS Eagle River PRSRT STD PRSRT U.S. Postage Permit No. 13 POSTAL PATRON POSTAL Saturday, Saturday, Sept. 20, 2014 20, Sept. (715) 479-4421 sidency restrictions apply. See dealer for details. ome customers will not qualify. Take delivery by 09-30-2014. AND THE THREE LAKES NEWS THE AND A SPECIAL SECTION OF THE VILAS COUNTY NEWS-REVIEW THE VILAS COUNTY SECTION OF SPECIAL A NORTH WOODS NORTH THE PAUL BUNYAN OF NORTH WOODS ADVERTISING WOODS OF NORTH BUNYAN THE PAUL Residency restrictions apply. See dealer for details. Not available with finance or lease offers. Take delivery by 09-30-2014. Re © Eagle River 1.0% APR for 60 months qualified buyers. Monthly payment is $16.67 every $1,000 you finance. Example down payment: 18%. S Publications, Inc. 1972 Inc. Publications, 715-479-442 Fax 715-479-6242 P.O. Box 1929 Eagle River, WI 54521 $11 – 25 words or less (one time). Additional word 30¢, payable in advance. Visa/MasterCard/ CLASSIFIEDS Discover ————————————————— ————————————————— MISCELLANEOUS FOR SALE: Energy King wood-burn- ————————————————— ing, hot-water furnace, $300. (715) 479- ARE YOU NEW TO THE EAGLE RIV- 1620. 1p-9449-28 ER, THREE LAKES, PHELPS, ————————————————— CONOVER, LAND O’ LAKES AND ST. LOG JAMBOREE: Ewen, Mich., Sept. GERMAIN AREA? Call Nicolet Wel- 26 & 27, entertainment & yard sales. come Service, at 1-(800) 513-1350. 1p-9456-28 Also Bundles of Joy baby packet for ————————————————— newborns to three months. 7315-tfc FOR SALE: 60,000-Btu propane fur- ————————————————— nace, top-side heat supply, electronic PERMANENT SUSPENDED OVER- ignitor, good condition, almost like new.
    [Show full text]
  • 2016 Raising Hope Auction Catalog
    2016 Raising Hope Auction Catalog Table of Contents Page Section 3 ONLINE ONLY 9 Edibles 12 Children’s Corner 15 Accessories, Clothing and Jewelry 17 Home and Family 20 Sports Fever 22 Getaways and Day Trips 27 Pampering, Spa and Fitness 29 Big Night Out: Shows and Events 33 Big Night Out: Wine and Dine The Fine Print FORMAT This auction consists of two sections, ONLINE ONLY, and SILENT ITEMS WITH PRE-BIDDING. Online Only items will be sold in an online auction www.biddingowl.com/HopeCenteratPullen ending June 4th and will NOT be available for bidding at the June 5th brunch event. Silent Items will be available for bidding through www.biddingowl.com/HopeCenteratPullen until Saturday, June 4th at noon. We will then take the highest bid on each silent item at noon on June 4th and transfer it to the paper bid sheets we will be using Sunday, June 5th where they will serve as the first bid during the event. ITEM PAYMENT AND PICKUP FOR ITEMS For payment and pickup of an Online Only item, you have two options. 1) You may pay and pick up the item at the Raising Hope Brunch on Sunday, June 5th at 12:30 PM (Tickets can be purchased at www.hopecenteratpullen.org. 2) You may also pay and pick up the item(s) anytime between Monday, June 6th and Monday, June 12th at The Hope Center, 1801 Hillsborough Street, Raleigh. Normal business hours are 9AM – 5PM. You may call Jeanne Lawson at 919-961-3811 for more information. If you bid on a Silent Item and you are the winning bid at the event but not in attendance, we will contact you on Monday, June 6th to coordinate payment and pickup of the item.
    [Show full text]
  • Raising Hope Show Your Leadership
    WE NEED YOUR SUPPORT As COVID-19 continues to spread without discrimination across the country, cancer patients are more vulnerable than ever, as they face unique clinical, social, and financial disadvantages. In these challenging times, cancer patients look to the Society as a trusted partner, and it's essential for us to deliver targeted, local emergency response to meet their specific needs. Typically, during our Galas and Balls, generous supporters would raise their paddles high to fund our mission. Now, we humbly ask you to raise your hands virtually in support of the following efforts: FUND THE NEED: KEY PRIORITIES RAISING HOPE $500 $1,000 $2,500 MISSION PADDLE RAISE Personal Health Manager Cancer Prevention Study 3 Reach to Recovery could help patients keep could help researchers could provide approximately 40 July 15 -September 15, 2020 track of important information better understand the many factors peer support sessions for breast and documents related to that cause or prevent cancer, cancer patients who are paired treatment, and appointments. including the future impact of with fellow survivor mentors. COVID-19. IMPACT OF COVID-19 In a recent survey we administered to thousands of cancer patients and survivors, 87% of those surveyed reported negative impacts on their care due to COVID-19. The situation is getting worse, not better, for cancer patients during this pandemic. $5,000 $10,000 $25,000 Hope Lodge for Healthcare 24/7 Cancer Helpline Cutting-Edge Research could cover operating costs for could pay for about 300 calls to could be a significant 100 rooms per night of free provide support and reduce investment in upcoming cancer SHOW YOUR lodging for first line responders isolation.
    [Show full text]
  • Escape to Margaritaville
    Media Contacts: Marketing (605) 731-2313 | (605) 731-2367 | [email protected] FOR IMMEDIATE RELEASE “IT WILL KNOCK YOUR FLIP-FLOPS OFF! THIS IS WHAT ESCAPISM IS ALL ABOUT.” — Entertainment Weekly JIMMY BUFFETT’S ESCAPE TO MARGARITAVILLE BROADWAY RETURNS TO SIOUX FALLS WITH THE HIT MUSICAL COMEDY SEPTEMBER 7-9 Sioux Falls, SD (8/30/2021) – Plan your escape to the new musical about the choices we make – and the people we become – once we’ve had a change in latitude. Jimmy Buffett’s ESCAPE TO MARGARITAVILLE will take the Washington Pavilion stage with three performances September 7-9. Tickets are available now for this tropical performance. “After more than a year and a half without touring musicals, our team absolutely cannot wait to welcome Broadway back to South Dakota,” said CEO Darrin Smith. “We simply could not ask for a better show to kick off a great 2021-22 Pavilion Performance Series. This show is like a big party on the stage, and I personally can’t wait to see it.” Sioux Falls is the second stop on a 20-city, 12-week tour of the popular feel-good musical comedy. ESCAPE TO MARGARITAVILLE tells the original story of two best friends escaping to an island vacation. Their lives are soon changed forever as they meet fun-loving islanders and learn the meaning of true love. Get ready for a hilarious and heartwarming musical with the most unforgettable songs from one of music’s greatest storytellers including “Fins,” “Volcano” and “Cheeseburger in Paradise.” USA Today calls it “A little slice of paradise!” and Entertainment Weekly raves, ““It will knock your flip-flops off!” “The pandemic reminded us of the power of theatre and the joy of experiencing it live, together.
    [Show full text]
  • NETFLIX – CATALOGO USA 20 Dicembre 2015 1. 009-1: the End Of
    NETFLIX – CATALOGO USA 20 dicembre 2015 1. 009-1: The End of the Beginning (2013) , 85 imdb 2. 1,000 Times Good Night (2013) , 117 imdb 3. 1000 to 1: The Cory Weissman Story (2014) , 98 imdbAvailable in HD on your TV 4. 1001 Grams (2014) , 90 imdb 5. 100 Bloody Acres (2012) , 1hr 30m imdbAvailable in HD on your TV 6. 10.0 Earthquake (2014) , 87 imdb 7. 100 Ghost Street: Richard Speck (2012) , 1hr 23m imdbAvailable in HD on your TV 8. 100, The - Season 1 (2014) 4.3, 1 Season imdbClosed Captions: [ Available in HD on your TV 9. 100, The - Season 2 (2014) , 41 imdbAvailable in HD on your TV 10. 101 Dalmatians (1996) 3.6, 1hr 42m imdbClosed Captions: [ 11. 10 Questions for the Dalai Lama (2006) 3.9, 1hr 27m imdbClosed Captions: [ 12. 10 Rules for Sleeping Around (2013) , 1hr 34m imdbAvailable in HD on your TV 13. 11 Blocks (2015) , 78 imdb 14. 12/12/12 (2012) 2.4, 1hr 25m imdbClosed Captions: [ Available in HD on your TV 15. 12 Dates of Christmas (2011) 3.8, 1hr 26m imdbClosed Captions: [ Available in HD on your TV 16. 12 Horas 2 Minutos (2012) , 70 imdb 17. 12 Segundos (2013) , 85 imdb 18. 13 Assassins (2010) , 2hr 5m imdbAvailable in HD on your TV 19. 13 Going on 30 (2004) 3.5, 1hr 37m imdbClosed Captions: [ Available in HD on your TV 20. 13 Sins (2014) 3.6, 1hr 32m imdbClosed Captions: [ Available in HD on your TV 21. 14 Blades (2010) , 113 imdbAvailable in HD on your TV 22.
    [Show full text]