Metastasis to the Appendix from Lung Adenocarcinoma Manifesting As Acute Appendicitis: a Case Report
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Appendix Cancer and Pseudomyxoma Peritonei (PMP) a Guide for People Affected by Cancer
Cancer information fact sheet Understanding Appendix Cancer and Pseudomyxoma Peritonei (PMP) A guide for people affected by cancer This fact sheet has been prepared What is appendix cancer? to help you understand more about Appendix cancer occurs when cells in the appendix appendix cancer and pseudomyxoma become abnormal and keep growing and form a peritonei (PMP). mass or lump called a tumour. Many people look for support after The type of cancer is defined by the particular being diagnosed with a cancer that cells that are affected and can be benign (non- is rare or less common than other cancerous) or malignant (cancerous). Malignant cancer types. This fact sheet includes tumours have the potential to spread to other information about how these cancers parts of the body through the blood stream or are diagnosed and treated, as well as lymph vessels and form another tumour at a where to go for additional information new site. This new tumour is known as secondary and support services. cancer or metastasis. Many people feel shocked and upset when told they have cancer. You may experience strong emotions The abdomen after a cancer diagnosis, especially if your cancer is rare or less common like appendix cancer or PMP. A feeling of being alone is usual with rare cancers, and you might be worried about how much is known about your type of cancer as well as how it will be managed. You may also be concerned about the cancer coming back after treatment. Linking into local support services (see last page) can help overcome feelings of isolation and will give you information that you may find useful. -
Carcinoid Tumor of Appendix: Review of Consecutive 5131 Appendectomy
J Surg Med. 2018;2(2):134-136. Research article DOI: 10.28982/josam.414055 Araştırma makalesi Carcinoid tumor of appendix: Review of consecutive 5131 appendectomy Apendiksin karsinoid tümörü: Ardışık 5131 apendektominin incelemesi İlyas Kudaş 1, Olgun Erdem 2, Ahmet Topçu 2, Abdullah Şişik 2 1 Department of General Surgery, Abstract Tekman State Hospital, Erzurum, Aim: Appendiceal carcinoid tumor (neuroendocrine tumor) is rarely seen, and it is frequently found incidentally Turkey after evaluation of appendectomy specimen. Histopathologically, the appendiceal carcinoid tumor is usually the 2 Department of General Surgery, University of Health Science, Umraniye type of enterochromafine cell and stems from a sub-epithelial cell population that differs from the Education and Research Hospital, neuroendocrine tumor in other regions. Although it is often detected in appendectomy, appendiceal one is the Istanbul, Turkey most common type of primary malignant lesion and is detected in 0.3-0.9% of patients with appendectomy. In this study, it is intended to present an appendix carcinoid tumor series that is diagnosed incidentally after appendectomy. Methods: 5131 appendectomy that was performed between years of 2009 and 2017 constituted the study universe. 35 (0.68%) patients diagnosed with carcinoid tumors were evaluated in the histopathological examination. The patients were recorded in terms of demographic data, clinical status, histopathology and surgical reports. Additional operations and follow-up data were noted. Results: 21 of the 35 patients with appendiceal carcinoid tumors were males, and 14 were women. Male/Female ratio was 1.5. The mean age of the patients was 27.3±11.0. There was no difference in terms of gender and age with other appendectomy patients who diagnosed non-tumor (p=0.476 and p=0.413, respectively). -
Integrated Clinico-Molecular Profiling of Appendiceal Adenocarcinoma
www.nature.com/bjc ARTICLE Molecular Diagnostics Integrated clinico-molecular profiling of appendiceal adenocarcinoma reveals a unique grade-driven entity distinct from colorectal cancer Kanwal Raghav 1, John P. Shen1, Alexandre A. Jácome1, Jennifer L. Guerra1, Christopher P. Scally2, Melissa W. Taggart3, Wai C. Foo3, Aurelio Matamoros4, Kenna R. Shaw5, Keith Fournier2, Michael J. Overman1 and Cathy Eng1 BACKGROUND: Appendiceal adenocarcinoma (AA) is an orphan disease with unique clinical attributes but often treated as colorectal cancer (CRC). Understanding key molecular differences between AA and CRC is critical. METHODS: We performed retrospective analyses of AA patients (N = 266) with tumour and/or blood next-generation sequencing (NGS) (2013–2018) with in-depth clinicopathological annotation. Overall survival (OS) was examined. For comparison, CRC cohorts annotated for sidedness, consensus molecular subtypes (CMS) and mutations (N = 3283) were used. RESULTS: Blood-NGS identified less RAS/GNAS mutations compared to tissue-NGS (4.2% vs. 60.9%, P < 0.0001) and showed poor concordance with tissue for well-/moderately differentiated tumours. RAS (56.2%), GNAS (28.1%) and TP53 (26.9%) were most frequent mutations. Well/moderately differentiated tumours harboured more RAS (69.2%/64.0% vs. 40.5%) and GNAS (48.7%/32.0% vs. 10.1%) while moderate/poorly differentiated tumours had more TP53 (26.0%/27.8% vs. 7.7%) mutations. Appendiceal adenocarcinoma (compared to CRC) harboured significantly fewer APC (9.1% vs. 55.4%) and TP53 (26.9% vs. 67.5%) and more GNAS mutations (28.1% vs. 2.0%) (P < 0.0001). Appendiceal adenocarcinoma mutation profile did not resemble either right-sided CRC or any of the four CMS in CRC. -
Common Surgical Diseases.Pdf
Common Surgical Diseases Second Edition Common Surgical Diseases An Algorithmic Approach to Problem Solving Second Edition Edited by Jonathan A. Myers, MD Assistant Professor of Surgery Director, Undergraduate Surgical Education Rush Medical College of Rush University Rush University Medical Center Chicago, IL 60612, USA Keith W. Millikan, MD Professor of Surgery Associate Dean, Surgical Sciences and Services Rush Medical College of Rush University Rush University Medical Center Chicago, IL 60612, USA Theodore J. Saclarides, MD Professor of Surgery Head, Section of Colon and Rectal Surgery Rush Medical College of Rush University Rush University Medical Center Chicago, IL 60612, USA Jonathan A. Myers, MD Keith W. Millikan, MD Assistant Professor of Surgery Professor of Surgery Director, Undergraduate Surgical Education Associate Dean, Surgical Sciences and Services Rush Medical College of Rush University Rush Medical College of Rush University Rush University Medical Center Rush University Medical Center Chicago, IL 60612, USA Chicago, IL 60612, USA Theodore J. Saclarides, MD Professor of Surgery Head, Section of Colon and Rectal Surgery Rush Medical College of Rush University Rush University Medical Center Chicago, IL 60612, USA ISBN 978-0-387-75245-7 e-ISBN 978-0-387-75246-4 Library of Congress Control Number: 2007937163 © 2008 Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. -
Intraperitoneal Chemotherapy for Peritoneal Metastases: Technical Innovations, Preclinical and Clinical Advances and Future Perspectives
biology Review Intraperitoneal Chemotherapy for Peritoneal Metastases: Technical Innovations, Preclinical and Clinical Advances and Future Perspectives Niki Christou 1,2,3,* , Clément Auger 3 , Serge Battu 3, Fabrice Lalloué 3 , Marie-Odile Jauberteau-Marchan 3, Céline Hervieu 3 , Mireille Verdier 3 and Muriel Mathonnet 1,3 1 Service de Chirurgie Digestive, Endocrinienne et Générale, CHU de Limoges, Avenue Martin Luther King, 87042 Limoges CEDEX, France; [email protected] 2 Department of Visceral Surgery, Geneva University Hospitals and Medical School, Geneva, Rue Gabrielle Perret-Gentil 4, 1205 Geneva, Switzerland 3 Laboratoire EA 3842, CAPtuR, Contrôle de l’Activation Cellulaire, Progression Tumorale et Résistance Thérapeutique, Faculté de Médecine, 2 rue du Docteur Marcland, 87025 Limoges CEDEX, France; [email protected] (C.A.); [email protected] (S.B.); [email protected] (F.L.); [email protected] (M.-O.J.-M.); [email protected] (C.H.); [email protected] (M.V.) * Correspondence: [email protected]; Tel.: +33-684-569-392 Simple Summary: The aim of this review is to emphazise the evolution of intraperitoneal chemother- apy for peritoneal metastasis. Over the last past decade, both delivery modes and conditions concerning hyperthermic intra-abdominal chemotherapy have evolved aiming at improving global and recurrence-free survival of malignant peritoneal diseases. We are waiting now more large Citation: Christou, N.; Auger, C.; randomized controlled trials to demonstrate the efficacy of such treatments. Battu, S.; Lalloué, F.; Jauberteau-Marchan, M.-O.; Hervieu, Abstract: (1) Background: Tumors of the peritoneal serosa are called peritoneal carcinosis. Their C.; Verdier, M.; Mathonnet, M. origin may be primary by primitive involvement of the peritoneum (peritoneal pseudomyxoma, Intraperitoneal Chemotherapy for peritoneal mesothelioma, etc.). -
Transport Tijdens Intraperitoneale Chemotherapie Modeling of Drug
Modelleren van geneesmiddelenverdeling en -transport tijdens intraperitoneale chemotherapie Modeling of Drug Delivery and Transport during Intraperitoneal Chemotherapy Margo Steuperaert Promotoren: prof. dr. ir. P. Segers, prof. dr. W. Ceelen, prof. dr. ir. C. Debbaut Proefschrift ingediend tot het behalen van de graad van Doctor in de ingenieurswetenschappen: biomedische ingenieurstechnieken Vakgroep Elektronica en Informatiesystemen Voorzitter: prof. dr. ir. K. De Bosschere Faculteit Ingenieurswetenschappen en Architectuur Academiejaar 2019 - 2020 ISBN 978-94-6355-307-0 NUR 954 Wettelijk depot: D/2019/10.500/115 Supervisors: Prof. Dr. Ir. Patrick Segers Prof. Dr. Wim Ceelen Prof. Dr. Ir. Charlotte Debbaut Research lab: Institute Biomedical Technology Biofluid, Tissue and solid Mechanics for medical applications (bio- MMeda) Ghent University Corneel Heymanslaan 10 - blok B (entrance 36) B-9000 Gent, Belgium Members of the exam committee: Chairman: prof. Dr. Ir. Patrick De Baets Faculty of Engineering and Architecture, UGent Secretary: Prof. Dr. Christian Vanhove Faculty of Engineering and Architecture, UGent Reading committee: Prof. Dr. Christian Vanhove Faculty of Engineering and Architecture, UGent Prof. Dr. Katrien Remaut Faculty of Pharmaceutics, UGent Prof. Dr. Ir. Pascal Verdonck Faculty of Engineering and Architecture, UGent Prof. Dr. Ir. Geraldine Heynderickx Faculty of Engineering and Architecture, UGent Department of Medical Physics, Dr. Steven Sourbron University of Leeds (UK) This research was supported by the FWO grant: G012513N (Integrated Dy- namic Functional Imaging and Numerical Simulation of Mass Transport for the Assessment of Intraperitoneal Chemotherapy for Carcinomatosis) TABLEOF CONTENTS Table of Contents vii List of Figures xi List of Tables xiii Abbreviations and Symbols xv Samenvatting xix Summary xxvii Introduction and Problem Statement xxxiii I Introduction, background and goal of this dissertation 1 1 Anatomy and physiology of the peritoneum 3 1.1 Macroscopic anatomy . -
Molecular Profiling of Appendiceal Adenocarcinoma and Comparison with Right-Sided and Left-Sided Colorectal Cancer
Author Manuscript Published OnlineFirst on January 28, 2019; DOI: 10.1158/1078-0432.CCR-18-3388 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. R Tokunaga et al. Molecular profiling of appendiceal adenocarcinoma. Page 1 Research Article: Translational Cancer Mechanisms and Therapy Molecular profiling of appendiceal adenocarcinoma and comparison with right-sided and left-sided colorectal cancer Ryuma Tokunaga1*, Joanne Xiu2, Curtis Johnston2, Richard M. Goldberg3, Philip A. Philip4, Andreas Seeber5, Madiha Naseem1, Jae Ho Lo1, Hiroyuki Arai1, Francesca Battaglin1, Alberto Puccini1, Martin D. Berger1, Shivani Soni1, Wu Zhang1, Jimmy J. Hwang6, Anthony F. Shields4, John L. Marshall7, Hideo Baba8, W. Michael Korn2, Heinz-Josef Lenz1 1Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA. 2Caris Life Sciences, Phoenix, USA 3West Virginia University Cancer Institute, Morgantown, USA 4Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, USA 5Department of Haematology and Oncology, Innsbruck Medical University, Innsbruck, Austria 6Levine Cancer Institute, Carolinas HealthCare System, Charlotte, USA 7Ruesch Center for The Cure of Gastrointestinal Cancers, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA 8Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan Running title: Molecular profiling of appendiceal adenocarcinoma Keywords: appendiceal adenocarcinoma; right-sided colorectal cancer; left-sided colorectal cancer; molecular profiling; mutation Funding: This work was supported by the Uehara Memorial Foundation, the National Cancer Institute (grant number P30CA014089), Dhont Family Foundation, San Pedro Peninsula Cancer Guild, and Daniel Butler Research Fund. Downloaded from clincancerres.aacrjournals.org on September 24, 2021. -
Vigilance for Medical Products of Human Origin
Annex I – Taxonomy tables used to classify occurrences in a structured way. Adverse Occurrence type taxonomy ADVERSE OCCURRENCE TAXONOMY LEVEL 1 LEVEL 2 LEVEL 3 LEVEL 4 LEVEL 1 LEVEL 2 LEVEL 3 LEVEL 4 Adenovirus Ehrlichia Arenavirus Elizabethkingia BK virus (BKV) Enterobacter Colorado tick fever virus Enterococcus Cytomegalovirus (CMV) Escherichia Dengue virus (DENV) Hafnia Enterovirus Klebsiella Epstein-Barr Virus (EBV) Legionella Hepatitis A Virus (HAV) Listeria Hepatitis B Virus (HBV) Morganella Hepatitis C Virus (HCV) Mycobacterium Hepatitis E virus (HEV) Mycoplasma Human Herpes Virus 6 (HHV-6) Oerskovia Human Herpes Virus 8 (HHV-8) Orientia Human immunodeficiency virus (HIV) Prevotella Human papillomavirus (HPV) Propionibacterium Herpes simplex virus (HSV) Proteus Viral Human T-lymphotropic Virus (HTLV) Bacterial Providencia Influenza virus Pseudomonas Harm to a Infection JC virus Harm to a recipient Infection Psychrobacter recipient Lymphocytic choriomeningitis virus (LCMV) Richettsia Parvovirus B19 Salmonella Rabies virus Serratia Ross River virus Staphylococcus Saint Louis encephalitis virus Stenotrophomonas Tick-borne encephalitis virus Streptococcus Zika Virus (ZIKV) Treponema West Nile virus (WNV) Veillonella Acinetobacter Yersinia Alcaligenes Acremonium Anaplasma Apophysomyces Bacillus Arthrographis Bacteroides Aspergillus Bacterial Bartonella Candida Fungal Brucella Coccidioides Cardiobacterium Cryptococcus Chlamydia Encephalitozoon Citrobacter Histoplasma Clostridium Paecilomyces 1 ADVERSE OCCURRENCE TAXONOMY LEVEL 1 LEVEL -
Appendix Cancer PMP Fact Sheet
A P P E N D I X C A N C E R A N D P S E U D O M Y X O M A P E R I T O N E I F A C T S H E E T O V E R V I E W O F A P P E N D I X C A N C E R & P S E U D O M Y X O M A P E R I T O N E I ( P M P ) Appendix cancer starts with a tumor in the cells of the appendix. There are many different types of tumors: (1) low-grade mucinous neoplasm of the appendix (LAMN), (2) high-grade mucinous neoplasm of the appendix (HAMN), (3) goblet cell carcinoid (defined by a unique combination of two types of cancer cells – neuroendocrine [carcinoid] and epithelial [adenocarcinoma]), (4) adenocarcinoma, further classified as: (a) well-differentiated, (b) moderately-differentiated, (c) poorly-differentiated and (d) signet ring cell (SRC). Appendiceal tumors frequently spread inside the abdominal cavity. Depending on the type of tumor, this can lead to a condition called peritoneal carcinomatosis or peritoneal surface malignancy. Pseudomyxoma peritonei (PMP) is the progressive accumulation of mucus-secreting or mucinous tumor cells within the abdomen and pelvis after an appendiceal tumor bursts through the wall and spreads mucinous cells throughout the surrounding surfaces. As mucinous tumor cells accumulate, the abdominal area becomes swollen and digestive function becomes impaired. In very rare cases, pseudomyxoma peritonei can arise from tumors located in organs other than the appendix, but the vast majority arise from appendiceal tumors. -
Cancers of the Appendix: Review of the Literatures
International Scholarly Research Network ISRN Oncology Volume 2011, Article ID 728579, 6 pages doi:10.5402/2011/728579 Review Article Cancers of the Appendix: Review of the Literatures Carl Ruoff,1 Louay Hanna,2 Wanqing Zhi, 2 Ghulamullah Shahzad,2 Vladimir Gotlieb,2 and Muhammad Wasif Saif3 1 New York Hospital Medical Center of Queens, Flushing, NY 11355, USA 2 Nassau University Medical Center and North Shore LIJ Health System, East Meadow, NY 11554, USA 3 Division of Hematology/Oncology, College of Physicians and Surgeons, Columbia University, New York, NY, USA Correspondence should be addressed to Ghulamullah Shahzad, [email protected] and Vladimir Gotlieb, [email protected] Received 24 May 2011; Accepted 26 June 2011 Academic Editor: Y. Akiyama Copyright © 2011 Carl Ruoff et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancers of the appendix are rare. Most of them are found accidentally on appendectomies performed for appendicitis. When reviewed, majority of the tumors were carcinoid, adenoma, and lymphoma. Adenocarcinomas of appendix are only 0.08% of all cancers and the treatment remains controversial. Here we are reporting a 46-year-old male presented with symptoms of appendicitis, diagnosed with adenocarcinoma of the appendix. The patient was treated with appendectomy and refused further surgical intervention to complete hemicolectomy. Up to date, he remains asymptomatic. We performed literature review of the tumors of the appendix. Most of the benign conditions are treated with surgery alone. Lymphomas require CHOP- like chemotherapy and carcinoid syndrome treatment with somatostatin analogues. -
Us 2018 / 0305689 A1
US 20180305689A1 ( 19 ) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2018 /0305689 A1 Sætrom et al. ( 43 ) Pub . Date: Oct. 25 , 2018 ( 54 ) SARNA COMPOSITIONS AND METHODS OF plication No . 62 /150 , 895 , filed on Apr. 22 , 2015 , USE provisional application No . 62/ 150 ,904 , filed on Apr. 22 , 2015 , provisional application No. 62 / 150 , 908 , (71 ) Applicant: MINA THERAPEUTICS LIMITED , filed on Apr. 22 , 2015 , provisional application No. LONDON (GB ) 62 / 150 , 900 , filed on Apr. 22 , 2015 . (72 ) Inventors : Pål Sætrom , Trondheim (NO ) ; Endre Publication Classification Bakken Stovner , Trondheim (NO ) (51 ) Int . CI. C12N 15 / 113 (2006 .01 ) (21 ) Appl. No. : 15 /568 , 046 (52 ) U . S . CI. (22 ) PCT Filed : Apr. 21 , 2016 CPC .. .. .. C12N 15 / 113 ( 2013 .01 ) ; C12N 2310 / 34 ( 2013. 01 ) ; C12N 2310 /14 (2013 . 01 ) ; C12N ( 86 ) PCT No .: PCT/ GB2016 /051116 2310 / 11 (2013 .01 ) $ 371 ( c ) ( 1 ) , ( 2 ) Date : Oct . 20 , 2017 (57 ) ABSTRACT The invention relates to oligonucleotides , e . g . , saRNAS Related U . S . Application Data useful in upregulating the expression of a target gene and (60 ) Provisional application No . 62 / 150 ,892 , filed on Apr. therapeutic compositions comprising such oligonucleotides . 22 , 2015 , provisional application No . 62 / 150 ,893 , Methods of using the oligonucleotides and the therapeutic filed on Apr. 22 , 2015 , provisional application No . compositions are also provided . 62 / 150 ,897 , filed on Apr. 22 , 2015 , provisional ap Specification includes a Sequence Listing . SARNA sense strand (Fessenger 3 ' SARNA antisense strand (Guide ) Mathew, Si Target antisense RNA transcript, e . g . NAT Target Coding strand Gene Transcription start site ( T55 ) TY{ { ? ? Targeted Target transcript , e . -
Mucinous Epithelial Neoplasms of the Appendix and Pseudomyxoma Peritonei Joseph Misdraji
Modern Pathology (2015) 28, S67–S79 & 2015 USCAP, Inc. All rights reserved 0893-3952/15 $32.00 S67 Mucinous epithelial neoplasms of the appendix and pseudomyxoma peritonei Joseph Misdraji Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA The classification of appendiceal mucinous neoplasms has been controversial, largely focused on a particular subset of low-grade mucinous tumors that, despite their innocuous appearance, can disseminate to the peritoneal cavity as pseudomyxoma peritonei (PMP). Recent WHO classification of these tumors as low-grade appendiceal mucinous neoplasms acknowledges their unique morphologic appearance and biologic behavior. Still, debate about the use of this term and its parameters continues to impede the adoption of consensus classification for appendiceal mucinous neoplasms. The classification of PMP has also been the subject of debate, with international authorities advocating for the use of malignant terminology to describe all grades of PMP, even though some authorities consider low-grade PMP to be dissemination of adenomatous epithelium in the peritoneum. Recent data also emphasize the importance of histologic grade of the peritoneal tumors in defining prognosis of these patients. Modern Pathology (2015) 28, S67–S79; doi:10.1038/modpathol.2014.129 Appendiceal mucinous tumors include a spectrum biology, and management of mucinous appendiceal of tumors, but within that spectrum is a fascinating tumors with an emphasis on low-grade tumors. low-grade tumor that has been the subject of Their differential diagnosis, natural history, and considerable debate. These tumors challenge our management are reviewed. In addition, entities very definition of malignancy and force us to commonly mistaken for appendiceal neoplasia will consider whether biology, morphology, or both be addressed.