biology Review Intraperitoneal Chemotherapy for Peritoneal Metastases: Technical Innovations, Preclinical and Clinical Advances and Future Perspectives Niki Christou 1,2,3,* , Clément Auger 3 , Serge Battu 3, Fabrice Lalloué 3 , Marie-Odile Jauberteau-Marchan 3, Céline Hervieu 3 , Mireille Verdier 3 and Muriel Mathonnet 1,3 1 Service de Chirurgie Digestive, Endocrinienne et Générale, CHU de Limoges, Avenue Martin Luther King, 87042 Limoges CEDEX, France;
[email protected] 2 Department of Visceral Surgery, Geneva University Hospitals and Medical School, Geneva, Rue Gabrielle Perret-Gentil 4, 1205 Geneva, Switzerland 3 Laboratoire EA 3842, CAPtuR, Contrôle de l’Activation Cellulaire, Progression Tumorale et Résistance Thérapeutique, Faculté de Médecine, 2 rue du Docteur Marcland, 87025 Limoges CEDEX, France;
[email protected] (C.A.);
[email protected] (S.B.);
[email protected] (F.L.);
[email protected] (M.-O.J.-M.);
[email protected] (C.H.);
[email protected] (M.V.) * Correspondence:
[email protected]; Tel.: +33-684-569-392 Simple Summary: The aim of this review is to emphazise the evolution of intraperitoneal chemother- apy for peritoneal metastasis. Over the last past decade, both delivery modes and conditions concerning hyperthermic intra-abdominal chemotherapy have evolved aiming at improving global and recurrence-free survival of malignant peritoneal diseases. We are waiting now more large Citation: Christou, N.; Auger, C.; randomized controlled trials to demonstrate the efficacy of such treatments. Battu, S.; Lalloué, F.; Jauberteau-Marchan, M.-O.; Hervieu, Abstract: (1) Background: Tumors of the peritoneal serosa are called peritoneal carcinosis. Their C.; Verdier, M.; Mathonnet, M. origin may be primary by primitive involvement of the peritoneum (peritoneal pseudomyxoma, Intraperitoneal Chemotherapy for peritoneal mesothelioma, etc.).