Early Predictors of Traumatic Glaucoma After Closed Globe Injury Trabecular Pigmentation, Widened Angle Recess, and Higher Baseline Intraocular Pressure
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CLINICAL SCIENCES Early Predictors of Traumatic Glaucoma After Closed Globe Injury Trabecular Pigmentation, Widened Angle Recess, and Higher Baseline Intraocular Pressure Ramanjit Sihota, MD, FRCS; Sunil Kumar, MD; Viney Gupta, MD; Tanuj Dada, MD; Seema Kashyap, MD; Rajpal Insan, MD; Geetha Srinivasan, MS Objective: To prospectively analyze the clinical and ul- glaucoma showed evidence of cyclodialysis, compared trasonographic biomicroscopy (UBM) features in eyes with 7 eyes with glaucoma (P=.001). The relative risk with closed globe injury, at the initial examination, that of developing traumatic glaucoma was also significantly would predict the occurrence of chronic traumatic glau- higher with hyphema, elevated baseline IOP, angle re- coma during a 6-month follow-up. cession of more than 180°, lens displacement, and wider angles on UBM. Methods: Forty consecutive eyes with closed globe in- jury and a chronically elevated intraocular pressure (IOP) Conclusions: Clinically, the presence of increased pig- of at least 21 mm Hg for a minimum of 3 months were mentation at the angle, elevated baseline IOP, hy- diagnosed as having traumatic glaucoma and compared phema, lens displacement, and angle recession of more with 52 eyes with closed globe injury and no evidence than 180° were significantly associated with the occur- of glaucoma. rence of chronic glaucoma after closed globe injury. On UBM findings, a wider angle and the absence of cyclo- Results: The median grade of trabecular pigmentation dialysis were significant predictors for the subsequent de- on gonioscopy in eyes with traumatic glaucoma was 3 velopment of traumatic glaucoma. compared with 2 in eyes without glaucoma (P=.001). On UBM findings, 18 eyes with closed globe injury without Arch Ophthalmol. 2008;126(7):921-926 RAUMA IS A COMMON CAUSE damage such as angle recession. The aim of of ocular morbidity and oc- this study was to evaluate eyes prospec- curs most often during tively with closed globe injury from the ini- childhood or in young tial examination, to identify early ocular adults.1,2 Glaucoma after findings that could be significantly associ- Tclosed globe injury is a major concern be- ated with the development of a chronic trau- cause many cases may go unnoticed and, matic glaucoma, and to compare clinical and without close follow-up, are diagnosed ultrasonographic biomicroscopy (UBM) many years later as having irreversible findings in eyes that developed and did not glaucomatous optic nerve damage.3,4 Two develop chronic glaucoma. peak incidences of glaucoma after trauma have been reported, less then 1 year and METHODS at least 10 years after trauma.5 A 3.4% in- cidence of glaucoma after ocular contu- Consecutive patients initially seeking treat- sion has been reported during a 6-month ment in the ophthalmic casualty department follow-up6 and up to 10% during the 10 after concussive closed globe injury during a Author Affiliation: Glaucoma years after trauma.7 1-year period were included for evaluation. De- Research Facility and Clinical Retrospective studies have identified ocu- tails of the ocular injury—mode of injury, time Services (Drs Sihota, Kumar, lar features commonly seen in eyes with from trauma to initial visit, and route, dose, and Gupta, Dada, Insan, and traumatic glaucoma, such as poor baseline duration of therapy—were recorded. Prior ocu- Srinivasan) and Department of lar problems and a family history of glaucoma Ocular Pathology (Dr Kashyap), visual acuity, hyphema, an angle recession were also noted. Informed consent was ob- Dr Rajendra Prasad Centre for of more than 180°, traumatic cataracts, dis- tained from all patients in accordance with the 3,6 Ophthalmic Sciences, All India placement of the lens, and iris injuries. Declaration of Helsinki. Institute of Medical Sciences, However, only a few eyes develop glau- A thorough ocular examination of both New Delhi, India. coma, despite the presence of traumatic eyes was performed, including best corrected (REPRINTED) ARCH OPHTHALMOL / VOL 126 (NO. 7), JULY 2008 WWW.ARCHOPHTHALMOL.COM 921 ©2008 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/26/2021 diagnosed as having a traumatic glaucoma. In the absence of Table 1. Demographic Data of 92 Patients such a chronically elevated IOP or evidence of glaucomatous With Closed Globe Injury optic neuropathy, eyes were diagnosed as having only a closed globe injury without glaucoma. Closed Globe Histopathological evaluation of the trabeculectomy speci- Injury Without Traumatic mens was performed in eyes that underwent filtering surgery. Glaucoma Glaucoma We used SPSS statistical software, version 10.0 (SPSS Inc, Characteristic (n = 52) (n = 40) P Value Chicago, Illinois) for comparing the variables between glau- Age, mean (SD), y 22.4 (11.0) 19.4 (9.5) .74 comatous and control eyes. A binary logistic regression analy- Sex, No. M:F 49:3 37:3 .90 sis was used to determine the relative risk of developing glau- Trauma to presentation interval, 10.8 (15.1) 9.5 (5.9) .59 coma, as evidenced by baseline clinical features and UBM mean (SD), d findings. A PϽ.05 was considered statistically significant. Un- Type of trauma, No. (%) less otherwise indicated, data are expressed as mean (SD). Cricket ball 23 (44) 17 (43) .77 Firecracker 9 (17) 8 (20) .90 Wooden stick 10 (19) 7 (18) .85 RESULTS Other 10 (19) 8 (20) .88 We reviewed 121 eyes of 121 consecutive patients older than 10 years who had had a recent closed globe injury. visual acuity, slitlamp biomicroscopic examination, fundus Ninety-two patients fulfilled inclusion criteria for the study examination with a ϩ90-diopter lens, and indirect ophthal- after exclusion of 13 patients younger than 10 years, moscopy without indentation. Intraocular pressure (IOP) 5 with pseudophakia, and 1 who had undergone a re- measurements on at least 3 occasions were recorded by means cent vitreoretinal surgery. of applanation tonometry. The zone of injury was recorded Forty of the 92 patients (43%) had a persistent eleva- and classified according to the location.8 Zone 1 injuries were tion of IOP (Ն21 mm Hg) for at least 3 months, ie, trau- superficial injuries limited to the bulbar conjunctiva, sclera, matic glaucoma. The remaining 52 patients (57%) had or cornea, including corneal abrasion and subconjunctival an IOP consistently less than 21 mm Hg, with no evi- hemorrhage. Zone 2 injuries involved structures in the ante- dence of glaucomatous optic neuropathy; these patients rior segment up to and including the lens apparatus, the lens constituted the closed globe injury group. Demo- zonules, and the pars plicata. Zone 3 injuries were posterior injuries involving the pars plana, choroid, retina, vitreous, or graphic data are presented in Table 1. optic nerve. When we classified the closed globe injury group with- Patients older than 10 years who were cooperative during out glaucoma by the zone of injury, 22 (42%) had a zone the UBM and gonioscopic examinations were included in the 1 injury; 20 (38%) had a zone 2 injury; and 10 (19%) study. Exclusion criteria were an open globe injury, primary had a zone 3 injury. The respective numbers in the trau- glaucoma or other preexisting cause of secondary glaucoma, matic glaucoma group were 1 (3%), 21 (53%), and 18 and a history of ocular surgery or laser therapy. (45%) (P=.01). Four weeks after the trauma, gonioscopy with 360° gonio- Ocular findings are listed in Table 2. Hyphema, base- photography and UBM (UBM P-40; Paradigm Medical Indus- line IOP, trabecular pigmentation, angle recession, and tries, Salt Lake City, Utah) were performed by an experienced lens displacement were statistically more frequent in the glaucomatologist (V.G.) who was masked to the patient’s his- tory and final diagnosis. On gonioscopic findings, the circum- traumatic glaucoma group. Four patients with trau- ferential extent of angle recession and cyclodialysis were noted matic glaucoma had a recurrence of bleeding within and pigmentation was graded as 0 (no pigmentation), 1 (faint), 5 days of the trauma, compared with none of the pa- 2 (average), 3 (heavy), or 4 (very heavy).6 tients with a closed globe injury. Ultrasonographic biomicroscopy images were obtained ra- A mean baseline IOP of 17.3 (5.0) mm Hg was re- dially every clock hour to find angle recession, cyclodialysis, corded in the closed globe injury group and 35.2 (12.8) iridodialysis, and lenticular subluxation or dislocation. The an- mm Hg in the traumatic glaucoma group (P=.001). Go- terior chamber depth, superior and inferior angle measure- nioscopic examination of the closed globe injury group ment in degrees, angle opening distance at 250 and 500 µm, revealed that 24 eyes had a normal angle structure. In and angle recess area were measured at the widest angle, with 1 eye, a cyclodialysis cleft was noted, associated with angle note of any other anterior segment abnormalities. All patients were followed up every month for 6 months and recession. Of the remaining 27 eyes, 22 had angle reces- as appropriate thereafter. At each visit, best corrected visual acu- sion of less than 180°; 3, of 180° to 270°; and 2, of more ity, applanation tonometry, and thorough anterior and poste- than 270°. On UBM examination, results showed that rior segment evaluations were performed. Humphrey field analy- 22 eyes had a normal angle; 23, an angle recession of less sis with a 30-2 SITA standard visual field (Humphrey Systems, than 180°; 5, an angle recession of 180° to 270°; Dublin, California) was recorded in patients with a best cor- and 2, an angle recession of more than 270° (Figure 1). rected visual acuity of more than 6/60. In the presence of a hy- In the traumatic glaucoma group, gonioscopic find- phema, patients underwent evaluation more frequently to moni- ings revealed that 3 eyes had normal angles, whereas 37 tor the IOP and corneal status.