Kanazawa Medical University Research Activities and Publications
VOL.29 2017
Kanazawa Medical University I N D E X
Code DepaertmentPage Code Depaertment Page
Basic Medical Science 0475 Department of Otorhinolaryngology ・・・・・・75 0100 Department of Anatomy Ⅰ ・・・・・・1 0485 Department of Head and Neck Surgery ・・・・・・77 0110 Department of Anatomy Ⅱ ・・・・・・2 0490 Department of Dermatology ・・・・・・79 0120 Department of Physiology Ⅰ ・・・・・・3 0500 Department of Urology ・・・・・・81 0130 Department of Physiology Ⅱ ・・・・・・4 0510 Department of Obstetrics and Gynecology ・・・・・・82 0140 Department of Biochemistry Ⅰ ・・・・・・6 0520 Department of Anesthesiology and 0150 Department of Biochemistry Ⅱ ・・・・・・7 Perioperative Medicine ・・・・・・84 0160 Department of Pharmacology ・・・・・・8 0540 Department of Physical and Rehabilitation 0170 Department of Pathology Ⅰ ・・・・・・9 Medicine ・・・・・・86 0180 Department of Pathology Ⅱ ・・・・・・11 0550 Department of Emergency Medicine ・・・・・・87 0190 Department of Microbiology ・・・・・・12 0570 Department of Community Medicine ・・・・・・88 0200 Department of Immunology ・・・・・・13 0575 Department of Gastroenterological Endoscopy ・・・・・・90 0210 Department of Medical Zoology ・・・・・・14 0577 Department of Cardiovascular Intervention ・・・・・・92 0220 Department of Pathology and Laboratory 0580 Department of Oral and Maxillofacial Surgery ・・・・・・93 edicine ・・・・・・15 0590 Department of Regenerative Medicine ・・・・・・95 0230 Department of Social and Environmental Medicine ・・・・・・17 School of Nursing 0240 Department of Epidemiology and Public Heaｌｔｈ ・・・・・・19 8010 Fundamental Nursing ・・・・・・96 0250 Department of Legal Medicine ・・・・・・22 8040 Maternity Nursing・Midwifery ・・・・・・97 0260 Department of Medical Education ・・・・・・23 8050 Pediatric Nursing ・・・・・・98 8060 Adult Nursing ・・・・・・99 Clinical Medicine 8070 Gerontological Nursing ・・・・・・100 0300 Department of Cardiology ・・・・・・24 8080 Community Health Nursing ・・・・・・101 0310 Department of Respiratory Medicine ・・・・・・26 8085 Psychiatric and Mental Health Nursing ・・・・・・102 0320 Department of Gastroenterology ・・・・・・28 8090 Home Care Nursing ・・・・・・103 0325 Department of Hepatology ・・・・・・30 8100 Medical Science ・・・・・・104 0330 Department of Nephrology ・・・・・・32 0340 Department of Diabetology and Endocrinology ・・・・・・34 Department of General Education 0350 Department of Hematology and Immunology ・・・・・・37 8610 Natural Science ・・・・・・106 0360 Department of Neurology ・・・・・・40 8620 Human Science ・・・・・・108 0363 Department of Medical Oncology ・・・・・・42 0366 Department of Infectious Diseases ・・・・・・44 University Hospital 0368 Department of General Internal Medicine ・・・・・・46 0675 Health Evaluation Center ・・・・・・110 0370 Department of Geriatric Medicine ・・・・・・48 0380 Department of Pediatrics ・・・・・・49 Medical Research Institute 0390 Department of Neuropsychiatry ・・・・・・51 7100 Department of Life Science ・・・・・・113 0400 Department of Radiology ・・・・・・54 7200 Department of Advanced Medicine ・・・・・・116 0412 Department of Cardiovascular Surgery ・・・・・・56 7310 Division of Innovative Research ・・・・・・117 0415 Department of Thoracic Surgery ・・・・・・57 7320 Division of Vision Research for Environmental 0420 Department of General and Digestive Surgery ・・・・・・60 Health ・・・・・・120 0430 Department of Orthopedics Surgery ・・・・・・62 7340 Division of Anticipatory Molecular Food Science 0440 Department of Neurosurgery ・・・・・・65 and echnology ・・・・・・125 0450 Department of Plastic and Reconstructive 7350 Division of Systems Bioscience for Drug Surgery ・・・・・・67 Discovery Based on Intrinsically Disordered 0460 Department of Pediatric Surgery ・・・・・・69 Proteins ・・・・・・128 0470 Department of Ophthalmology ・・・・・・71 7400 Research Support Cente ・・・・・・129 Code DepaertmentPage Code Depaertment Page
Himi Municipal Hospital 9100 Himi Municipal Hospital ・・・・・・131
Basic Medical Science
0100 Department of Anatomy Ⅰ
Faculty
Title Name Field of Specialization Professor HATTA Toshihisa developmental biology, neuroscience Professor HIGASHI Nobuaki macroscopic anatomy, embryology Associate Professor SAKATA Hiromi Developmental toxicology Senior Assistant Professor SHIMADA Hiroki Medical science of free radical Assistant Professor TSUKADA Tsuyoshi Developmental biology, Neuroscience, Neurosurgery
Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant, apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry, human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide, scavenger, VDAC, anomaly of muscles and blood vessels
Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine network. 2. Cytochemical study of the cytotoxicity by reactive oxygen species. 3. Biological functions of VDAC family proteins. 4. Macroscopic studies on the variations of muscles and blodd vessels. 5. Comparative anatomical studies on the brain evolution
Publications
Originals 0100B001 Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura:JunB regulates angiogenesis and
neurovascular parallel alignment in mouse embryonic skin, Jonal of Cell Science, 130:5;916-926, 2017.
0100B002 (Akai Takuya), Hatta Toshihisa, Shimada Hiroki, Mizuki Keiji, Kudo Nae, Hatta Taizo, Otani Hiroki:Extracranial outflow of particles solved in cerebrospinal fluid: Fluorescein injection study, Congenital Anomalies, 58:93-98,
2017.
- 1 - 0110 Department of Anatomy Ⅱ
Faculty
Title Name Field of Specialization Professor HONMA Satoru gross anatomy Associate Professor ITO Tetsufumi neuroanatomy Senior Assistant Professor YASUTAKA Satoru gross anatomy Assistant Professor KOMINAMI Rieko neuroanatomy
Keywords of Research
arthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, ontogenesis, immunohistochemistry, electron microscopy, hippocampus, reconstruction, electron microscopy, vascularization, Neuroanatomy, FIB/SEM, BMI, gustatory
Outline of Research
Theme of researches 1)Human gross anatomy 2)Neural network of the basal ganglia 3)Circuit of gustatory in the central nervous system 4)Tissue reconstruction and vascularization of human hippocampus
Publications
Originals 0110B001 (Morita N), Ito T, Hasegawa RP, Murase K:Development of Functional Interlaminar Pathways in the Mouse Superior Colliculus Revealed by Optical Imaging with Axonal Labeling, Journal of Biosciences and Medicines,
5:8;11-35, 2017.
0110B002 (Mitsuhiro Matsuo), Satoru Honma, Takahiro Sonomura, Mitsuaki Yamazaki:Clinical anatomy of the cephalic vein
for safe performance of venipuncture, JA Clinical Reports, 3:50, 2017.
0110B003 (Mamoru Uemura), Takamitsu Arakawa, Reiko Kominami, Satoru Honma, Akimichi Takemura:Identification of the optimal method for removing the capsule from the acinus of the rat's mandibular glands when preparing specimens
for superficical morphology examination, Okajimas Folia Anat.Jpｎ., 94:3;109-113, 2017.
- 2 - 0120 Department of Physiology Ⅰ
Faculty
Title Name Field of Specialization Professor KATO Nobuo Brain Science Senior Assistant Professor ONO Munenori Neuroscience Senior Assistant Professor TAJIMA Nobuyoshi molecular physiology
Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, field potential, propagating signal, horizontal propagation, oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording, intracellular staining, Neuroethology, Behavioral test battery, BK channel
Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not a mere stardust. A single neuron integrates many inputs thereunto, so as to determine whether the output signal is released or not. Neurons are connected to each other by synapses to build neuron network, which underlies brain function. Our primary research interest is to elucidate, in molecular terms, how one or more neurons are able to regulate neuron excitability and synaptic efficiency. In particular, we are interested in studying in vitro how the versatile intracellular messenger calcium ion mediates a number of signals differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability.
Publications
Originals 0120B001 Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura:JunB regulates angiogenesis and
neurovascular parallel alignment in mouse embryonic skin, Jonal of Cell Science, 130:5;916-926, 2017.
0120B002 Xianwen Luo, Yuan Shui, Furong Wang, Ryo Yamamoto, Nobuo Kato:Impaired retention of depression-like
behavior in a mouse model of Alzheimer's disease, IBRO Reports, 2:81-86, 2017.
0120B003 Munenori Ono, Deborah C Bishop, Douglas L Oliver:Identified GABAergic and Glutamatergic Neurons in the Mouse Inferior Colliculus Share Similar Response Properties, The Journal of Neuroscience, 37:37;8952-8964, 2017.
Presentations at Conference
International Conference (Presentations) 0120I001 Ono M, Bishop DC, Oliver DL:Neuronal Sensitivity to the Interaural Time Difference, The 2nd International
Symposium on the Science of Mental Time, Nara, 2017.09.
- 3 - 0130 Department of Physiology Ⅱ
Faculty
Title Name Field of Specialization SHIBAMOTO Professor Circulatory Physiology Toshishige Professor KURATA Yasutaka Cardiac Electrophysiology Associate Professor TANIDA Mamoru Circulatory Physiology Assistant Professor KUDA Yuｈichi Circulatory Physiology
Keywords of Research
physiology, circulatory shock, systemic anaphylaxis, pulmonary circulation, pulmonary edema, cardiac electrophysiology, ion channels, pacemaker mechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics, computer simulation, sympathetic nervous system, smooth muscle, vascular electrophysiology, artery, vein
Outline of Research
Our works widely cover the area of cardiovascular physiology and autonomic nervous system. We are particularly interested in the mechanisms of regulations of organ circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity and arrhythmias as well as their regulations. We also explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, the possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers, and dynamical mechanisms of early afterdepolarizations in long QT syndrome. We also aim to elucidate the central mechanisms for autonomic regulations of appetite-related hormones and circulatory shock.
Publications
Originals 0130B001 Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T:Mouse Anaphylactic Hypotension Is Characterized by Initial Baroreflex Independent Renal Sympathoinhibition Followed by
Sustained Renal Sympathoexcitation., Frontiers in Physiology, 8:669, 2017.
0130B002 Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T:Biphasic Renal
Sympathetic Response to Hemorrhagic Hypotension in Mice., Shock, 48:5;576-582, 2017.
0130B003 Kuda Y, Shibamoto T, Yang W, Zhang T, Tanida M, Kurata Y:Blockade of β2-adrenoceptor, rather than β1- adrenoceptor, deteriorates cardiac anaphylaxis in isolated blood-perfused rat hearts., Cardiol J, 24:4;403-408,
2017.
0130B004 Kurata Y, Tsumoto K, Hayashi K, Hisatome I, Tanida M, Kuda Y, Shibamoto T:Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical
models., Am J Physiol Heart Circ Physiol, 312:1;H106-H127, 2017.
0130B005 (Tsumoto K), Kurata Y, Furutani K, Kurachi Y:Hysteretic dynamics of multi-stable early afterdepolarisations with repolarisation reserve attenuation: a potential dynamical mechanism for cardiac arrhythmias., Sci Rep, 7:1;10771,
2017.
- 4 - 0130B006 (Ohnohara T), Hisatome I, Kurata Y, Li P, Notsu T, Morikawa K, Otani N, Yoshida A, Iitsuka K, Kato M, Miake J, Ninomiya H, Higaki K, Shirayoshi Y, Nishihara T, Itoh T, Nakamura Y, Nishimura M:Molecular mechanism underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells., J Arrhythm,
33:3;226-233, 2017.
0130B007 (Ikeda N), Nakazawa N, Kurata Y, Yaura H, Taufiq F, Minato H, Yoshida A, Ninomiya H, Nakayama Y, Kuwabara M, Shirayoshi Y, Hisatome I:Tbx18-positive cells differentiated from murine ES cells serve as proepicardial
progenitors to give rise to vascular smooth muscle cells and fibroblasts., Biomed Res, 38:4;229-238, 2017.
0130B008 (Ho YY), Nakato J, Mizushige T, Kanamoto R, Tanida M, Akiduki S, Ohinata K:l-Ornithine stimulates growth
hormone release in a manner dependent on the ghrelin system., Food Funct, 8:6;2110-2114, 2017.
0130B009 (Yamamoto N), Shibata M, Ishikuro R, Tanida M, Taniguchi Y, Ikeda-Matsuo Y, Sobue K:Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through
activation of ERK and PI3K pathways., Neuroscience, 362:70-78, 2017.
Presentations at Conference
International Conference (Presentations) 0130I001 Tanida M, Shibamoto T:Biphasic response of renal sympathetic nerve to hemorrhagic shock in anesthetized mice.,
The 40th Annual Conference on Shock, Florida, 2017.
0130I002 Shibamoto T, Yang W, Kuda Y, Zhang T, Tanida M, Kurata Y:β2-adrenoceptor blockade augments anaphylaxis- induced increase in pulmonary vascular permeability in anesthetized mice., European Respiratory Society
International Congress 2017, Milan, 2017.
0130I003 Shibamoto T, Wang M, Kuda Y, Zhang T, Yang W, Tanida M, Kurata Y:Systemic hypertension-induced left atrial pressure elevation accounts for the pathogenesis of neurogenic pulmonary edema in anesthetized rats., The 22nd
Asian Pacific Society of Respirology Congress 2017, Sydney, 2017.
- 5 - 0140 Department of Biochemistry Ⅰ
Faculty
Title Name Field of Specialization Professor IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins Assistant Professor SAKASAI Ryo DNA damage response induced by anti-cancer drugs Assistant Professor SUNATANI Yumi Function of DNA damage repair protein Assistant Professor MATSUI Tadashi Molecular biology, DNA repair, p53-binding proteins
Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction
Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2, that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 in cellular responses to DNA DSBs.
Publications
Originals 0140B001 Ryo Sakasai, Mayu Isono, Mitsuo Wakasugi, Mitsumasa Hashimoto, Yumi Sunatani, Tadashi Matsui, Atsushi Shibata, Tsukasa Matsunaga, Kuniyoshi Iwabuchi:Aquarius is required for proper CtIP expression and homologous recombination repair, SCIENTIFIC REPORTS, 7:13808, 2017.
- 6 - 0150 Department of Biochemistry Ⅱ
Faculty
Title Name Field of Specialization Professor YONEKURA Hideto Molecular mechanisms of angiogenesis, Alternative mRNA processing Senior Assistant Professor IKEDA Takayuki Molecular mechanisms of angiogenesis, Alternative mRNA processing Assistant Professor YOSHITOMI Yasuo Molecular mechanisms of angiogenesis and vasculogenesis TAKATSUJI-SAITO Assistant Professor neuroscience, molecular biology, regenerative medicine Hidehito
Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor, cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications, endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing, centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen receptor,
Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing 2. Cellular and molecular mechanisms in angiogenesis 3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction 4. Molecular mechanisms in development of diabetic vascular complications
Publications
Originals 0150B001 Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura:JunB regulates angiogenesis and
neurovascular parallel alignment in mouse embryonic skin, Journal of Cell Science, 130:5;916-926, 2017.
0150B002 Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata, Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.
Presentations at Conference
International Conference (Symposium) 0150H001 (Y.Yamada), K.Sakai, Y.Chiba, B.Hev, D.Mahboubi, CraigRhodes, Y.Yoshitomi, S. Fukumoto, T.Nakamura: Epiprofin is a multi-functional factor essential to promote dental epithelial stem cell commitment to the ameloblast lineage and its proliferation and differentiation, The 2017 Japan-NIH joint Symposium on Advances in Biomedical
Research and Disease, Sendai, 2017.
- 7 - 0160 Department of Pharmacology
Faculty
Title Name Field of Specialization Kinetics of NO(nitric oxide)-related compounds in cardiovascular Professor ISHIBASHI Takaharu system Electrophysiological and pharmacological study of excitable and non- Professor NISHIO Matomo excitable cells, Pharmocology of cardiovascular drugs Electrophysiology and behavioural pharmacology in central and Associate Professor MASUOKA Takayoshi periphenal nervous system Senior Assistant Professor TAWA Masashi Cardiovascular pharmacology
Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, Ca2+ imaging, coronary circulation, nitric oxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug, proliferation, cell biology, hippocampal synapses, muscarinic acetylcholine receptor, peripheral sensory neuron, autonomic neuron, central nervous system, metabotropic glutamate receptor, receptorology,
Outline of Research
1 Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells 2 Signaling mechanisms of bioactive substances 3 Electropharmacology of the drugs acting on the cardiovascular system 4 Pharmacological study of the ischemic cardiomyocytes 5 Kinetics of NO(nitric oxide)-related compounds in cardiovascular system 6 Pharmacological and electrophysiclogical studies on the neurophysiological mechanisms of memory and pain regulation
Publications
Originals 0160B001 Masuoka Takayoshi, Kudo Makiko, Yamashita Yuka, Yoshida Junko, Imaizumi Noriko, Muramatsu Ikunobu, Nishio Matomo, Ishibashi Takaharu:TRPA1 Channels Modify TRPV1-Mediated Current Responses in Dorsal Root
Ganglion Neurons, FRONTIERS IN PHYSIOLOGY, 8:1-9, 2017.
0160B002 Muramatsu Ikunobu, Uwada Junsuke, Masuoka Takayoshi, Yoshiki Hatsumi, Sada Kiyonao, Lee Kung-Shing, Nishio Matomo, Ishibashi Takaharu, Taniguchi Takanobu:Regulation of synaptic acetylcholine concentrations by acetylcholine transport in rat striatal cholinergic transmission, JOURNAL OF NEUROCHEMISTRY, 143:1;76-86,
2017.
- 8 - 0170 Department of PathologyⅠ
Faculty
Title Name Field of Specialization Professor KIYOKAWA Etsuko Experimental Pathology, Fluorescent Imaging Senior Assistant Professor HIRATA Eishu Tumour cell biology, Neurosurgery Assistant Professor ICHIKAWA Takehiko Fluorescent Imaging Assistant Professor KOBAYASHI Ryosuke Reproductive medicine
Keywords of Research
in vivo imaging, FRET, polarity, cancer, lens epithelial cell, sphingomyelin, epithelial regeneration,
Outline of Research
We observed signal transduction pathways in mice and cells expressing FRET biosensors, to understand cancer development and invasion/metastasis, and epithelial regeneration.We also develop the system to manipulate cell signaling to understand the molecular mechanisms for morphology Focusing on the lens epithelial cells, we are now investigating roles of DOCK5, an activator for Rac1, in the epithelial morphology and maintenance.
Publications
Originals 0170B001 E.Kubo, S.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, Dhirendra P.Singh:FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity., Journal of Cellular and Molecular Medicine,
21:5;916-928, 2017.
0170B002 Haruna Takeda, Etsuko Kiyokawa:Activation of Erk in ileal epithelial cells engaged in ischemic-injury repair,
Scientific Reports, 7:16469, 2017.
0170B003 (Asako Sasahara), Kana Tominaga, Tatsunori Nishimura, Masao Yano, Etsuko Kiyokawa, Miki Noguchi, Masakuni Noguchi, Hajime Kanauchi, Toshihisa Ogawa, Hiroshi Minato, Keiichiro Tada, Yasuyuki Seto, Arinobu Tojo, Noriko Gotoh:An autocrine / paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of
breast cancer stem-like cells, Oncotarget, 8:15;24869-24881, 2017.
0170B004 Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation of
multiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.
Reviews 0170C001 Hirata E, Sahai E:Tumor Microenvironment and Differential Responses to Therapy., Cold Spring Harbor
Perspectives in Medicine, 7:a026781, 2017.
Presentations at Conference
International Conference (Presentations) 0170I001 Naoko Shibata, Shinsuke Shibata, Teppei Shibata, Etsuko Kiyokawa, Hiroshi Sasaki, Eri Kubo:Comparison of gene expression profiles in human pterygium and UV-induced gene expressions in human conjunctival epithelium, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.
- 9 - 0170I002 Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P. Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.
0170I003 Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi Sasaki, Eri Kubo:Konck-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.
- 10 - 0180 Department of PathologyⅡ
Faculty
Title Name Field of Specialization Professor UEDA Yoshimichi Bone and soft tissue tumor, Pulmonary pathology Associate Professor SATO Katsuaki Diagnostic pathology of tumor Assistant Professor SHIMASAKI Miyako molecular pathology of the lung cancer
Keywords of Research
lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic histopathology, phospholipid, regeneration of cartilage, steroid induced femoral neuritis, mesenchymal stem cell, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB
Outline of Research
1. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelial- mesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene network/pathway analysis. 2. Molecular pathological diagnosis by FISH using probes origination from BAC clones and RT-PCR methods. 3. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM degradation and matrix metalloproteinases.
Publications
Originals 0180B001 (Kotaro Higashi), Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki, Yuka Nakamura, Manabu Oguchi, Tsutomu Takegami, Naoto Watanabe:High FDG uptake on PET is associated with negative cell-to-cell adhesion
molecule E-cadherin expression in lung adenocarcinoma, Annals of nuclear medicine, 31:590-595, 2017.
0180B002 Toru Ichiseki, Shusuke Ueda, Yoshimichi Ueda, Masanobu Tuchiya, Ayumi Kaneuji, Norio Kawahara:Involvement of necroptosis, a newly recognized cell death type, in steroid-induced osteonecrosis in a rabbit model, International
journal of medical sciences, 14:110-114, 2017.
0180B003 Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Yoshimichi Ueda, Masanobu Tsuchiya, Ayumi Kaneuji, Norio Kawahara:Prevention of glucocorticoid-associated osteonecrosis by intravenous administration of mesenchymal
stem cells in a rabbit model, BMC musculoskeletal disorders, 18:480, 2017.
Reviews 0180C001 Katsuo Usuda, Takuma Matsui, Nozomu Motono, Yuichiro Machida, Munetaka Matoba, Hisao Tonami, Yoshimichi Ueda, Hidetaka Uramoto:Diagnostic benefits and prospects of diffusion-weighted magnetic resonance imaging
(DWI) for thoracic tumor, The Journal of the Japanese Association for Chest Surgery, 6:5;305-311, 2017.
Case Reports 0180D001 Keiji Fujimoto, Masaru Nakagawa, Katsuaki Sato, Tatsuro Tanaka, Nobuhiko Miyatake, Keita Yamazaki, Yuko Tsuruyama, Yuki Okushi, Kazuaki Okino, Kiyotaka Mukai, Katsuhito Miyazawa, Hitoshi Yokoyama:A patient with tuberous sclerosis in whom dialysis was introduced due to hemorrhaging from oncocytic papillary renal cell
carcinoma, Journal of Japanese Society for Dialysis Therapy, 50:93-100, 2017.
- 11 - 0190 Department of Microbiology
Faculty
Title Name Field of Specialization Professor HIGUCHI Masaya Virology, Hematology, Oncology, Cellular biology Associate Professor HIMEDA Toshiki Neurovirology Assistant Professor OKUWA Takako Neurovirology Assistant Professor UTANI Koh-ichi Cellular biology
Keywords of Research
Ubiquitin specific peptidase 10, Theiler’s virus, Saffold virus,
Outline of Research
Functional analysis of the deubiquitinating enzyme USP10 in stress response and innate immunity. Mechanism of persistent infection and pathogenesis of Theilovirus (Theiler's virus and Saffold virus).
Publications
Originals 0190B001 Okuwa Takako, Sasaki Yutaka, Matsuzaki Yoko, Himeda Toshiki, Yoshino Naoto, Hongo Seiji, Ohara Yoshiro, Muraki Yasushi:The epitope sequence of S16, a monoclonal antibody against influenza C virus hemagglutinin-
esterase fusion glycoprotein, FUTURE VIROLOGY, 12:3;93-101, 2017.
Reviews 0190C001 Masaya Higuchi:Regulation of intracellular stress responses by the pleiotropic deubiquitinase USP10, Journal of
Kanazawa Medical University, 42:2;41-47, 2017.
Short Communications 0190E001 (Ito Hisato), Miyagaki Satoshi, Sakaue Satoshi, Matsui Fumihiro, Katsumi Yoshiki, Otabe Osamu, Torii Jun, Itagaki Tsutomu, Himeda Toshiki, Okuwa Takako, Ohara Yoshiro:Saffold Cardiovirus Infection in a 2-Year-Old Boy with
Acute Pancreatitis, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 70:1;105-107, 2017.
- 12 - 0200 Department of Immunology
Faculty
Title Name Field of Specialization Professor ONAI Nobuyuki Professor(Additional Post) KOHNO Hiroyuki Experimental Pathology, Tumor immunology Senior Assistant Professor YABE-WADA Toshiki Immunology, Functional biochemistry, Structural biochemistry Assistant Professor MATSUBA Shintaro Immunological pharmacology
Keywords of Research
The origin, development, and function of mononuclear phagocytes, Dendritic cells, Monocytes/Macrophages, Allergic effector cells, Innate immune responses, Cytokines
Outline of Research
Our research is focused on the regulation mechanisms of various immune responses.In the years, we have characterized several proteins that are involved in cytokine trafficking and the regulation of serine protease activity using mouse models. Specific areas of interest include; The origin, development, and function of mononuclear phagocytes (dendritic cells, monocytes, and macrophages). The regulation of cytokine production from innate immune cells. The role of endogenous serine protease inhibitors in allergic effector cells.
Publications
Originals 0200B001 S.Matsuba, T.Yabe-Wada, K.Takeda, T.Sato, M.Suyama, T.Takai, T. Kikuchi, T. Nukiwa, A.Nakamura: Identification of Secretory Leukoprotease Inhibitor As an Endogenous Negative Regulator in Allergic Effector Cells,
FRONTIERS IN IMMUNOLOGY, 8:1538, 2017.
0200B002 Nobuyuki Onai, Jumpei Asano, Rumiko Kurosaki, Shoko Kuroda, Toshiaki Ohteki:Flexible fate commitment of E2- 2high common DC progenitors implies tuning in tissue microenvironments, International Immunology, 29:10;443-
456, 2017.
Presentations at Conference
International Conference (Presentations) 0200I001 Toshiki Yabe-Wada, Shintaro Matsuba, Kazuya Takeda, Akira Nakamura, Caroline C Philpott, Nobuyuki Onai:Involvement of poly-rC binding proteins in posttranscriptional regulation of Sortilin, the cytokine trafficking
mediator, The 5th Annual Meeting of the International Cytokine and Interferon Society, Kanazawa, 2017.
0200I002 Nobuyuki Onai, Toshiaki Ohteki:Identification of Flt3-ligand producing cells by generating Flt3-ligand mCherry
reporter mouse, 5th Annual Meeting of the international Cytokine and Interferon Society, Kanazawa, 2017.10.
- 13 - 0210 Department of Medical Zoology
Faculty
Title Name Field of Specialization Associate Professor MURAKAMI Manabu Infection-mediated arthropod Senior Assistant Professor OIKAWA Yosaburo diagnosis of parasitic disease, tick-borne disease
Keywords of Research
parasite, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating antigen, excretory/secretory products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba, atopic dermatitis, mite, Myobia musculi, Leptotrombidium, Japanese encephalitis Virus, mosquito, Culex tritaeniorhynchus, Culex tritaeniorhynchus, Aedes albopictus
Outline of Research
The main subjects of our department are as follows: 1.Development of immunological and molecular biological diagnosis of parasitic diseases. 2.Epidemiological research of tick-born diseases in the Noto Peninsula,Ishikawa Prefect. 3.Investigation of mosquito situation around the pigpen in Ishikawa prefecture, and JE virus distribution.
Publications
Originals 0210B001 Murakami Manabu, Hori Kiyoe, Kitagawa Yoko, Oikawa Yosaburo, Kamimura Kiyoshi, Takagemi Tsutomu:An Ecological Survey of Mosquitoes and the Distribution of Japanese Encephalitis Virus in Ishikawa Prefecture, Japan,
between 2010 and 2014, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 70:4;362-367, 2017.
0210B002 Iwabu-Itoh Yukie, Bazartseren Boldbaatar, Naranbaatar Oyunnomin, Yondonjamts Enkhmandakh, Furuno Kiwa, Lee Kyunglee, Sato Kozue, Kawabata Hiroki, Takada Nobuhiro, Andoh Masako, Kajita Hiroko, Oikawa Yosaburo, Nakao Minoru, Ohnishi Makoto, Watarai Masahisa, Shimoda Hiroshi, Maeda Ken, Takano Ai:Tick surveillance for Borrelia miyamotoi and phylogenetic analysis of isolates in Mongolia and Japan., Ticks and Tick-borne Diseases,
8:6;850-857, 2017.
Others
0210F001 (Shin-ichi Hiramatsu), Yosaburo Oikawa:Records of ticks in Kaga area, Ishikawa Prefecture, 43:29-32, 2017.
- 14 - 0220 Department of Pathology and Laboratory Medicine
Faculty
Title Name Field of Specialization Surgical pathology, Pathological study of head and neck, lung, Professor MINATO Hiroshi mediastinum, and pleura Senior Assistant Professor KUROSE Nozomu surgical pathology, molecular pathology Senior Assistant Professor NAKADA Satoko surgical pathology Assistant Professor KOBAYASHI Eriko surgical pathology, molecular pathology Assistant Professor SHIOYA Akihiro Surgical pathology Assistant Professor AIKAWA Akane Surgical pathology
Keywords of Research
pathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood gas analysis, pulmonary function test, pulmonary pathology, lung, mediastinum, and pleura, head and neck, salivary gland
Outline of Research
Since atherosclerosis and its complications account for approximately up to 30% of cause of human death in the whole world, it is very critical to overcome this issue from the economical as well as medical aspects. I first focused on the histopathological viewpoints that the initiation to progression of atherosclerosis basically depends on inflammatory response. In order to elucidate its mechanism, I have thoroughly performed the in vivo experiments together with the extensively morphological to biochemical and molecular analyses from the wide view, by using various genetically modified animal models of mice or rabbits. Furthermore, I recently aim to multidimensionally and comprehensively re-evaluate these chronic inflammatory diseases including some kinds of malignancy, via overlooking the entity of metabolic syndrome, manifesting as not only atherosclerosis but diabetes mellitus (DM) or non-alcoholic steatohepatitis (NASH).
Publications
Originals 0220B001 Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki, Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose, Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.
Case Reports 0220D001 Mizuno Takuro, Kiyosawa Jun, Fukuda Akihiro, Watanabe Seiji, Kurose Nozomu, Nojima Takayuki, Kanda Tsugiyasu:Infective endocarditis following tumor necrosis factor-α antagonist therapy for management of psoriatic erythroderma: a case report., Journal of medical case reports, 11:1;35, 2017.
Short Communications 0220E001 Yuzo Shimode, Hiroyuki Tsuji, Takahiro Fukuhara, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda, Kentaro Yamada, Kazuhiro Kishimoto, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takayuki Nojima, Hiromi Takeuchi:Examination of Selective Low-pressure Fine Needle Aspiration Cytology Under Ultrasound Guidance,
YONAGO ACTA MEDICA, 60:3;209-212, 2017.
- 15 - Presentations at Conference
International Conference (Symposium) 0220H001 Yuzo Shimode, Hiroyuki Tsuji, Kazuhiro Kishimoto, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda, Kentaro Yamada, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takahiro Fukuhara:Examination of selective low- pressure fine needle aspiration cytology under ultrasound guidance, 2nd Congress of Asia-Pacific Society of
Thyroid Surgery, Naha, 2017.11.
International Conference (Presentations) 0220I001 A.Hiroguchi, Y.Osaka, J.Sakamoto, T.Shibata, H.Minato, T.Sasagawa:Identification of HPV infection type for
Squamous cell carcinoma, 31th International Papillomavirus Conference, Capetown, 2017.02.
0220I002 Seiko Miura, Nobuhiko.Ueda, Toshio.Onishi, Yasuto.Tomita, Hideto.Fujita, Shinichi.Kinami, Yasuharu.Nakano, Takeo.Kosaka, Akane.Aikawa, Hiroshi.Minato, Takayuki.Nojima:Multilocular cystic intrahepatic cholangiocarcinoma:A case report, Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato- Pancreato-Billiary Associaion. The 29th Meeting of Japanese Society of Hepato-Billiary-Pancreatic Surgery, Yokohama, 2017.06.
0220I003 Nobuhiko Ueda, Seiko Miura, Yasuto Tomita, Toshio Onishi, Hideto Fujita, Shinichi Kinami, Yasuharu Nakano, Takeo Kosaka, Akane Aikawa, Hiroshi Minato, Takayuki Nojima:Surgical management of intraducyal papillary mucinous neoplasms, Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Billiary
Associaion. The 29th Meeting of Japanese Society of Hepato-Billiary-Pancreatic Surgery, Yokohama, 2017.06.
- 16 - 0230 Department of Social and Environmental Medicine
Faculty
Title Name Field of Specialization Professor ISHIZAKI Masao Occupational Health, Job stress Associate Professor SAKURAI Masaru Cardiovascular epidemiology, preventive cardiology Assistant Professor HORI Kaori Pediatirc cardiology
Keywords of Research
occupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work, work time
Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies for health promotion
Publications
Originals 0230B001 (Koshi Nakamura), Masaru Sakurai, Yuko Morikawa, Shin-ya Nagasawa, Katsuyuki Miura, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Motoko Nakashikma, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Serum ferritin, insulin resistance, and β-cell dysfunction: a prospective study in normoglycemic Japanese men, Experimental and
clinical endocrinology & diabetes, 125:1;12-20, 2017.
0230B002 M.Sakurai, K.Yoshita, K.Nakamura, K.Miura, T.Takamura, S-Y.Nagasawa, Y.Morikawa, T.Kido, Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, M.Ishizaki, H.Nakagawa:Skipping breakfast and 5-year changes in body mass
index and waist circumference in Japanese men and women, Obesity Science & Practice, 3:2;162-170, 2017.
0230B003 (Hirokazu Kakuda), Junji Kobayashi, Masaru Sakurai, Masahiro Kakuda, Noboru Takekoshi:The effect of tofogliflozin treatment on postprandial glucose and lipid metabolism in Japanese men with type 2 diabetes: A pilot
study, Journal of clinical medicine research, 9:5;403-409, 2017.
0230B004 (Rie Oka), Kyoko Shibata, Masaru Sakurai, Mitsuhiro Kometani, Masakazu Yamagishi, Kenichi Yoshimura, Takashi Yoneda:Trajectories of postload plasma glucose in the development of type 2 diabetes in Japanese adults, Journal
of Diabetes Research, 2017:5307523, 2017.
0230B005 (Toshinari Takamura), Yuki Kita, Masatoshi Nakagen, Masaru Sakurai, Yuki Isobe, Yumie Takeshita, Kohzo Kawai, Takeshi Urabe, Shuichi Kaneko:Weight-adjusted lean body mass and calf circumference are protective against
obesity-associated insulin resistance and metabolic abnormalities, Heliyon, 3:7;e00347, 2017.
0230B006 (Kazuhiro Nogawa), Masaru Sakurai, Masao Ishizaki, Teruhiko Kido, Hideaki Nakagawa, Yasushi Suwazono: Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark
dose analysis, Journal of Applied Toxicology, 37:8;962-966, 2017.
0230B007 K.Kawaura, T.Itoh, K.Hamada, H.Kitakata, S.Azukisawa, H.Okamura, S.Urashima, M.Sakurai, M.Ishizaki:Selection of Methods for Percutaneous Endoscopic Gastrostomy(PEG)that is more Safety and Useful Techniques on the
Patients., CLINICAL INVESTIGATION, 7:3;111-118, 2017.
0230B008 (Hirokazu Kakuda), Junji Kobayashi, Masaru Sakurai, Noboru Takekoshi:The Effects of Tofogliflozin on Glucose
Metabolism and Uric Acid, Progress in Medicine, 37:10;1219-1223, 2017.
- 17 - Presentations at Conference
International Conference (Presentations) 0230I001 Shinya Nagasawa, Katsuyuki Miura, Masaru Sakurai, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yasushi Suwazono, Kazuhiro Nogawa, Hideaki Nakagawa:Longitudinal association between body weight change and 6-year change of blood pressure in Japanese men, EPI|LIFESTYLE2017, Portland, 2017.03.
- 18 - 0240 Department of Epidemiology and Public Health
Faculty
Title Name Field of Specialization Professor NISHINO Yoshikazu Epidemiology of cancer, preventive medicine Environmental epidemiology, Environmental health sciences, Professor NISHIJO Muneko Epidemiology of cadmium pollution Professor(Additional Post) MORIKAWA Yuko Cardiovascular epidemiology, occupational medicine Senior Assistant Professor NAGASAWA Shinya Cardiovascular epidemiology, preventive cardiology
Keywords of Research
epidemiology, public health, cancer, hypertension, diabetes mellitus, screening, shift work, nutrition, calcium, stress, smoking, insulin resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease, cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide, community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin
Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases Environmental Epidemiology Epidemiology of Occupation-related Diseases Epidemiology of Congenital Anomalies Epidemiology of Interactable Diseases Clinical Epidemiology
Publications
Originals 0240B001 (Keiko Kubo), Kazuhiro Nogawa, Teruhiko Kido, Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono:Estimation of Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants of an Environmentally Exposed River Basin in Japan, Risk analysis : an official publication of the Society for Risk
Analysis, 37:1;20-26, 2017.
0240B002 (Koshi Nakamura), Masaru Sakurai, Yuko Morikawa, Shin-ya Nagasawa, Katsuyuki Miura, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Motoko Nakashikma, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Serum ferritin, insulin resistance, and β-cell dysfunction: a prospective study in normoglycemic Japanese men, Experimental and
clinical endocrinology & diabetes, 125:1;12-20, 2017.
0240B003 M.Sakurai, K.Yoshita, K.Nakamura, K.Miura, T.Takamura, S-Y.Nagasawa, Y.Morikawa, T.Kido, Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, M.Ishizaki, H.Nakagawa:Skipping breakfast and 5-year changes in body mass
index and waist circumference in Japanese men and women, Obesity Science & Practice, 3:2;162-170, 2017.
0240B004 (Amartuvshin Bor), Muneko Nishijo, Hiroshi Nishimaru, Tomoya Nakamura, Nghi Ngoc Tran, Quang Van Le, Yusaku Takamura, Jumpei Matsumoto, Yoshikazu Nishino, Hisao Nishijo:Effects of high fat diet and perinatal dioxin exposure on development of body size and expression of platelet-derived growth factor receptor beta in the rat
brain, Journal of Intergrative Neuroscience, 16:4;453-470, 2017.
0240B005 (Junya Sado), Tetsuhisa Kitamura, Yuri Kitamura, Ling Zha, Rong Liu, Tomotaka Sobue, Yoshikazu Nishino, Hideo Tanaka, Tomio Nakayama, Ichiro Tsuji, Hidemi Ito, Takaichiro Suzuki, Kota Katanoda, Suketami Tominaga, for the Three-Prefecture Cohort Studu Group:Rationale, design, and profile of the Three-Prefecture Cohort in Japan: A
15-year follow-up, Journal of Epidemiology, 27:4;193-199, 2017.
- 19 - 0240B006 (Yoichiro Kakugawa), Hiroshi Tada, Masaaki Kawai, Takashi Suzuki, Yoshikazu Nishino, Seiki Kanemura, Takanori Ishida, Noriaki Ohuchi, Yuko Minami:Associations of obesity and physical activity with serum and intratumoral sex steroid hormone levels among postmenopausal women with breast cancer:analysis of paired serum and tumor tissue
samples, Breast Cancer Res Treat, 162:1;115-125, 2017.
0240B007 (K.Sugiyama), Y.Sugawara, Y.Tomata, Y.Nishino, A.Fukao, I.Tsuji:The association between coffee consumption and bladder cancer incidence in a pooled analysis of the Miyagi Cohort Study and Ohsaki Cohort Study., European
journal of cancer prevention, 26:2;125-130, 2017.
0240B008 Muneko Nishijo, Kowit Nambunmee, Dhitiwass Suvagandha, Witaya Swaddiwudhipong, Werawan Ruangyuttikarn, Yoshikazu Nishino:Gender-specific impact of cadmium exposure on bone metabolism in older people living in a cadmium-polluted area in Thailand, International Journal of Envitronmental Research and Publich Health, 14:4;401,
2017.
0240B009 Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro Kawano,Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki, Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose, Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.
0240B010 Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Teruhiko Kido:Causes of death in patients with Itai-itai disease suffering from severe chronic cadmium poisoning: a nested case-control analysis of a
follow-up study in Japan, BMJ Open, 7:7;e015694, 2017.
0240B011 (Hirata Takumi), Sugiyama Daisuke, Nagasawa Shin-Ya, Murakami Yoshitaka, Saitoh Shigeyuki, Okayama Akira, Iso Hiroyasu, Irie Fujiko, Sairenchi Toshimi, Miyamoto Yoshihiro, Yamada Michiko, Ishikawa Shizukiyo, Miura Katsuyuki, Ueshima Hirotsugu, Okamura Tomonori:A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan., European journal of epidemiology,
32:547-557, 2017.
0240B012 (H.Nakagawa), H.Ito, S.Hosono, I.Oze, H.Mikami, M.Hattori, Y.Nishino, H.Sugiyama, K.Nakata, H.Tanaka: Changes in trends in colorectal cancer incidence rate by anatomic site between 1978 and 2004 in Japan., European
journal of cancer prevention, 26:4;269-276, 2017.
0240B013 (Xian Liang Sun), Teruhiko.Kido, Seijiro.Honma, Eitetsu.Koh, Rie.Okamoto, Ho Dung Manh, Shoko.;Maruzeni, Muneko.Nishijo, Hideaki.Nakagawa, , Takeshi.Nakano, Takumi.Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le Ke Son:The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in
Vietnamese men, Science of the Total Environment, 595:842-848, 2017.
0240B014 (Kishi Reiko), Zhang Jun Jim, Ha Eun-Hee, Chen Pau-Chung, Tian Ying, Xia Yankai, Tsuchiya Kenji J, Nakai Kunihiko, Kim Sungkyoon, Hong Soo-Jong, Hong Yun-Chul, Lee Jeong-Rim, Jan Mohamed Hamid Jan B, Parajuli Rajendra Prasad, Adair Linda S, Chong Yap Seng, Guo Yue Leon, Wang Shu-Li, Muneko Nishijo, Kido Teruhiko, Tai Pham-The, Nandasena Sumal:Birth Cohort Consortium of Asia: Current and Future Perspectives,
Epidemiology (Cambridge, Mass.), 28:Suppl 1;19-34, 2017.
0240B015 (J.Sado), T.Kitamura, Y.Kitamura, T.Sobue, Y.Nishino, H.Tanaka, T.Nakayama, I.Tsuji, H.Ito, T.Suzuki, K.Katanoda, S.Tominaga, Three-Prefecture Cohort Study Group:Association between coffee consumption and all-
sites cancer incidence and mortality, Cancer Science, 108:10;2079-2087, 2017.
0240B016 (Kathryn Demanelis), Shama Virani, Justin A. Colacino, Niladri Basu, Muneko Nishijo, Werawan Ruangyuttikarn, Witaya Swaddiwudhipong, Kowit Nambunmee, Laura S. Rozek: Cadmium exposure and age-associated DNA methylation changes in non-smoking women from northern Thailand, Environmental Epigenetics, 3:2;dvx006, 2017.
- 20 - Presentations at Conference
International Conference (Presentations) 0240I001 Shinya Nagasawa, Katsuyuki Miura, Masaru Sakurai, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yasushi Suwazono, Kazuhiro Nogawa, Hideaki Nakagawa:Longitudinal association between body weight change and 6-year
change of blood pressure in Japanese men, EPI|LIFESTYLE2017, Portland, 2017.03.
0240I002 Muneko Nishijo, Hideaki Nakagawa, Kazuhiro Nogawa, Yasushi, Suwazono, Teruhiko Kido:Cancer mortality of residents living in the cadmium-polluted Jinzu River basin in Toyama,Japan, 14th International Conference on the
Biogeochemistry of Trace Elements, Zurich, 2017.07.
0240I003 Natsuko Hatsusaka, Hisanori Miyashita, Naoki Tanimura, Yoshikazu Nishino, Eri Kubo, Hiroshi Sasaki:Ocular UV
exposure and cataract risk in highly myopic eyes, International Conference on the Lens, Kona, 2017.12.
- 21 - 0250 Department of Legal Medicine
Faculty
Title Name Field of Specialization Professor MIZUKAMI Hajime Legal Medicine,Forensic pathology,DNA polymorphism KOBAYASHI Assistant Professor Legal medicine,DNA polymorphism Masamune Assistant Professor TAKESHITA Hiroshi Legal medicine,Forensic pathology
Keywords of Research
drug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K,
Outline of Research
Mechanism of methamphetamine abuse Immunohistochemical analysis of brain damage in foreusic autopy cases Application of proteinase K for diatome detection in the diagnosis of drowning
Publications
Originals 0250B001 Hara Shuichi, Kobayash Masamune, Kuriiwa Fumi, Kurosaki Kunihiko, Mizukami Hajime:Gene expression in rat
striatum following carbon monoxide poisoning, Genomics data, 12:74-75, 2017.
- 22 - 0260 Department of Medical Education
Faculty
Title Name Field of Specialization medical education, clinical neurology, clinical sleep medicine, Professor HORI Ariyuki neurophysiology, medical informatics, problem-based learning Senior Assistant Professor TAKAMURA Akiteru Comunity-based Medical Education, Simulated education medical informatics, electronic medical record system, medical Senior Assistant Professor KURODA Naohiro educatin
Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL,
Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training course before medical practice, management of medical informatics, practical training course using simulators, developing new assessment for students’ practice, and providing new educational environment using e-shyllabi.
Publications
Originals 0260B001 Takamura Akiteru, Ito Sayori, Maruyama Kaori, Ryo Yusuke, Saito Manami, Fujimura Shuhei, Ishiura Yuna, Hori Ariyuki:Quality of basic life support education and automated external defibrillator setting in schools in Ishikawa,
Japan, PEDIATRICS INTERNATIONAL, 59:3;352-356, 2017.
0260B002 Takamura Akiteru, Misaki Hidekazu, Takemura Yousuke, Community and Interns' Perspectives on Community-
Participatory Medical Education: From Passive to Active Participation, Family medicine, 49:7;507-513, 2017.
Reviews 0260C001 A.Takamura, M.Matsumoto, S.Ishikawa.:Rural Health in Japan: Past and future., Rural and Remote Health,
17:4;4521, 2017.
Case Reports 0260D001 Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda:Gastroenteritis in Japanese Females Caused by Shigella flexneri without Definite. Infection Route: A Case Report and Mini-Review of Literature, Journal Clinical Case Reports,
7:9;10001021, 2017.
0260D002 A.Takamura, R.Sangen, Y.Furumura, D.Usuda, Y.Kasamaki, T.Kanda:Diagnosis of myxedema coma complicated by
renal failure: a case report, Clinical Case Reports, 5:4;399-402, 2017.
0260D003 Akiteru Takamura, Ariyuki Hori:Recurrent Translent Perivascular Inflammation of the Carotid artery syndrome with temporary carotid plaque on ultrasonography: a case report, Clinical Case Reports, 5:11;1847-1851, 2017.
- 23 -
Clinical Medicine
0300 Department of Cardiology
Faculty
Title Name Field of Specialization Professor KAJINAMI Kouji Atherosclerosis, lipid metabolism Associate Professor KAWAI Yasuyuki Ischemic heart disease, Coronary intervention Associate Professor AKAO Hironobu Ischemic heart disease, Coronary intervention Associate Professor FUJIOKA Nakaba Arrhythmia, Catheter ablation Associate Professor TSUCHIYA Taketsugu Ischemic heart disease, Coronary intervention (Additional Post) Senior Assistant Professor WAKASA Minoru Heart failure Assistant Professor AOKI Hirofumi Heart failure Assistant Professor SAITO Ryuhei Ischemic heart disease, Coronary intervention Assistant Professor TAKEDA Kenji Molecular Biology Assistant Professor WATANABE Makoto Ischemic heart disease, Coronary intervention FUJIBAYASHI Assistant Professor Arrhythmia, Catheter ablation Kousuke Assistant Professor TAKANO Shintaro Arrhythmai, Catheter ablation Assistant Professor TAKAMURA Takaaki Ischemic heart disease, Coronary intervention Assistant Professor ISHIDA Ryoko Ischemic heart disease, Coronary intervention (Additional Post) Assistant Professor KITAGAWA Katsuhide Ischemic heart disease, Coronary intervention (Additional Post)
Keywords of Research
heart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease, autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT, myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP, microvascular angina, gene polymorphism, circadian variation
Outline of Research
1 Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases 2 Development of new therapeutics using the gene expression modification or the stem cell research technique 3 Visualization and quantification of the biological signal in cardiovascular system
- 24 - Publications
Originals 0300B001 Kamioka Norihiko, Soga Yoshimitsu, Kuramitsu Shoichi, Iida Osamu, Hirano Keisuke, Suzuki Kenji, Kawasaki Daizo, Yamaoka Terutoshi, Suematsu Nobuhiro, Shintani Yoshiaki, Miyashita Yusuke, Takahashi Hiroki, Tsuchiya Taketsugu, Shinozaki Norihiko, Okazaki Shinya, Ando Kenji:Clinical outcomes of balloon angioplasty alone versus nitinol stent implantation in patients with small femoropopliteal artery disease: Observations from the Retrospective Multicenter Analysis for Femoropopliteal Stenting (REAL-FP), Catheterization and cardiovascular
interventions, 90:5;790-797, 2017.
0300B002 (K.Suzuki), Y.Mizutani, Y.Soga, O.Iida, D.Kawasaki, Y.Yamauchi, K.Hirano, R.Koshida, D.Kamoi, J.Tazaki, M.Higashitani, Y.Shintani, T.Yamaoka, S.Okazaki, N.Suematsu, T.Tsuchiya, Y.Miyashita, N.Shinozaki, H.Takahashi, N.Inoue:Efficacy and Safety of Endovascular Therapy for Aortoiliac TASC D Lesions., Angiology,
68:1;67-73, 2017.
0300B003 M.Watanabe, Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi, T.Tsuchiya, H.Nakanishi, K.Saito, M.Takeuchi, K.Kajinami:Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived
advanced glycation end products., Journal of cardiology, 69:4;625-631, 2017.
0300B004 Takamura Taka-aki, Tsuchiya Taketsugu, Oda Minako, Watanabe Makoto, Saito Ryuhei, Sato-Ishida Ryoko, Akao Hironobu, Kawai Yasuyuki, Kitayama Michihiko, Kajinami Kouji:Circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) as a novel predictor of clinical outcome after endovascular therapy in patients with
peripheral artery disease (PAD), ATHEROSCLEROSIS, 263:192-197, 2017.
0300B005 Tanabe Nobuhiro, Ikeda Satoshi, Tahara Nobuhiro, Fukuda Keiichi, Hatano Masaru, Ito Hiroshi, Nakayama Tomotaka, Anzai Toshihisa, Hashimoto Akiyoshi, Inoue Teruo, Kajinami Kouji, Kihara Yasuki, Kinoshita Hideyuki, Kuwahara Koichiro, Murohara Toyoaki, Okazaki Osamu, Sakai Satoshi, Satoh Toru, Takeda Yutaka, Takeishi Yasuchika, Taniguchi Mitsugu, Watanabe Hiroshi, Yamamoto Takeshi, Yamauchi-Takihara Keiko, Yoshioka Koichiro, Sasayama Shigetake:Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension, CIRCULATION JOURNAL,
81:9;1360-1367, 2017.
0300B006 Soga Yoshimitsu, Takahara Mitsuyoshi, Iida Osamu, Yamauchi Yasutaka, Hirano Keisuke, Fukunaga Masashi, Zen Kan, Suzuki Kenji, Shintani Yoshiaki, Miyashita Yusuke, Tsuchiya Taketsugu, Yamaoka Terutoshi, Ando Kenji: Efficacy of CilostAzol for Below-the-Knee Artery Disease after Balloon AnGioplasty in PatiEnts with Severe Limb Ischemia (CABBAGE Trial), Annals of vascular surgery, 45:22-28, 2017.
- 25 - 0310 Department of Respiratory Medicine
Faculty
Title Name Field of Specialization Professor TOGA Hirohisa clinical respiratory medicine, sleep disordered breathing Professor OSANAI Kazuhiro lung cell and molecular biology, COPD Professor ISHIZAKI Takeshi Pulmonary circulation Associate Professor MIZUNO Shiro lung cell and molecular biology，COPD Associate Professor IGUCHI Masaharu Respiratory Medicine (Additional Post) Senior Assistant Professor OIKAWA Taku clinical respiratory medicine, lung cancer Senior Assistant Professor NAKAGAWA Ken clinical respiratory medicine, lung cancer Assistant Professor FUJIMOTO Yuki clinical respiratory medicine Assistant Professor KOJIMA Koji clinical respiratory medicine Assistant Professor SAITO Masatoshi clinical respiratory medicine, sleep，sleep disordered breathing Assistant Professor TAKAHARA Yutaka clinical respiratory medicine Assistant Professor KAMEDA Mari clinical respiratory medicine Assistant Professor SHINOMIYA Shohei clinical respiratory medicine Assistant Professor KATO Ryo chronic obstructive pulmonary disease
Keywords of Research
acute lung injury, cytokine, nitoric oxide, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic reflection technique, lung cancer, apoptosis
Outline of Research
1. Pathogenesis and therapy of acute lung injury 2. Cell biology of pulmonary alveolar epithelium 3. Pathogenesis and therapy of sleep-disordered breathing 4. Cell biology of lung cancer cells
Publications
Originals 0310B001 Kazuhiro Osanai, Keisuke Nakase, Takashi Sakuma, Kazuaki Nishiki, Masafumi Nojiri, Ryo Kato, Masatoshi Saito, Yuki Fujimoto, Shiro Mizuno, Hirohisa Toga:Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant
lung surfactant homeostasis in Ruby rats, Respiratory Research, 18:70, 2017.
0310B002 Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki, Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose, Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.
- 26 - 0310B003 Shiro Mizuno, Takeshi Ishizaki, Maiko Kadowaki, Masaya Akai, Kohei Shiozaki, Masaharu Iguchi, Taku Oikawa, Ken Nakagawa, Kazuhiro Osanai, Hirohisa Toga, Jose Gomez-Arroyo, Donatas Kraskauskas, Carlyne D Cool, Herman J Bogaard, Norbert F voelkel:p53 Signaling Pathway Polymorphisms Associated With Emphysematous
Changes in Patients With COPD, CHEST, 152:1;58-69, 2017.
Case Reports 0310D001 Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda:Gastroenteritis in Japanese Females Caused by Shigella flexneri without Definite. Infection Route: A Case Report and Mini-Review of Literature, Journal Clinical Case Reports,
7:9;10001021, 2017.
0310D002 Yutaka Takahara, Ryo Kato, Ken Nakagawa, Shiro Mizuno, Kazuhiro Osanai, Hirohisa Toga:A case of pulmonary arteriovenous malformation having difficulty in differential diagnosis of the hemoptysis during each menstrual
period, Annals of the Japanese Respiratory Society, 6:3;215-219, 2017.
Presentations at Conference
International Conference (Presentations) 0310I001 K.Nishiki, S.mizuno, M.Nojiri, T.Oikawa, K.Nakagawa,K.Osanai, T.Ishizaki, H.Toga:Serum Creatinine Levels Referenced By Cystatin C Are Ａssociated With Disease Severity In Patients With COPD, American Thoracic
Society 2017 International Conference, Washington,D.C., 2017.05.
0310I002 M.Nojiri, S.Mizuno, T.Oikawa, K.Nakagawa, K.Osanai, T.Ishizaki, H.Toga:Effect Of Emphysema Heterogeneity And Adrb2 Polymorphisms On Bronchodilator Response In Patients With COPD, American Thoracic Society 2017
International Conference, Washington,D.C., 2017.05.
0310I003 K.Osanai, M.Zhou, T.Sakuma, K.Nakase, M.Nojiri, S.Mizuno, H.Toga:Exogenous Expression of Lysophosphatidylcholine Acyltransferase 1 Attenuates Oleic Acid-induced Acute Lung Injury in Rats, FASEB
Science Research Conference, New Orleans, 2017.08.
- 27 - 0320 Department of Gastroenterology
Faculty
Title Name Field of Specialization Professor ARISAWA Tomiyasu Gastro-intestinal disorders NAKAMURA Associate Professor Endoscopic thcrapy of early gastric cancer Masakatsu Associate Professor SHIMASAKI Takeo Molecular Oncology, Pancreatic cancer , tissue engineering． (Additional Post) Senior Assistant Professor OTSUKA Toshimi Clinico-pathological study of nonalcoholic steatohepatitis Senior Assistant Professor HAYASHI Ranji Inflammatory Bowel Disease Assistant Professor NOMURA Tomoe Gastro-intestinal disorders Assistant Professor OOTA Masafumi Gastro-intestinal disorders
Keywords of Research
alcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholic steatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment, treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis
Outline of Research
1 Basic and clinical study of digestive disease ①Treatment for esophageal and gastric varices associated with portal hypertension ②Endoscopic treatment for early cancer of the esophagus, stomach and colon ③Hepatic support system for severe alcoholic hepatitis ④Clinical feature and treatment for nonalcoholic steatohepatitis 2 Experimental study of alcoholic organ injury ①Pathogenesis and treatment for alcoholic hepatitis ②Pathogenesis of hepatic fibrosis induced by alcohol ③Effect of alcohol on chemical carcinogenesis of the liver ④Pathogenesis for nonalcoholic steatohepatitis
Publications
Originals 0320B001 Toshikuni Nobuyuki, Tsuchishima Mutsumi, Fukumura Atsushi, Arisawa Tomiyasu, Tsutsumi Mikihiro:Associations of Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic and
Nonalcoholic Steatohepatitis, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2017:9127847, 2017.
0320B002 Arisawa Tomiyasu, Nakamura Masakatsu, Otsuka Toshimi, Jing Wu, Sakurai Naoko, Takano Hikaru, Hayashi Tasuku, Ota Masafumi, Nomura Tomoe, Hayashi Ranji, Shimasaki Takeo, Tahara Tomomitsu, Shibata Tomoyuki: Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative
colitis in Japan, WORLD JOURNAL OF GASTROENTEROLOGY, 23:29;5364-5370, 2017.
- 28 - Presentations at Conference
International Conference (Symposium)
0320H001 Tomiyasu Arisawa:Genetic alterations in FD patients, ANMA&JSNM Joint Meeting 2017, Osaka, 2017.03.
International Conference (Presentations) 0320I001 Tomiyasu Arisawa, Hikaru Takano, Tasuku Hayashi, Wu Jing, Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Toshimi Otsuka, Takeo Shimasaki, Masakatsu Nakamura:THE PRE-MICRORNA938,TARGETING 1L-17L 3'- UTR,GENE POLYMORPHISMS IS ASSOCIATED WITH THE RISK FOR DAP-KINASE HYPERMETHYLATION
IN HP INFECTED JAPANESE SUBJECTS, DDW2017, Chicago, 2017.05.
- 29 - 0325 Department of Hepatology
Faculty
Title Name Field of Specialization TSUCHISHIMA Professor Anti-viral therapy of viral hepatitis Mutsumi Professor TSUTSUMI Mikihiro Mechanism of alcoholic liver disease Associate Professor TOSHIKUNI Nobuyuki Interventional therapy for hepatocellular carcinoma Associate Professor SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer Associate Professor OZAKI Kazuaki Mechanism of portal hypertention in alcoholic liver injury Senior Assistant Professor JOSEPH George Mechanism of hepatic fibrosis Senior Assistant Professor HAYASHI Nobuhiko Mechanism of nonalcoholic fatty liver disease Senior Assistant Professor SAITO Takashi Treament for metabolic syndrome Senior Assistant Professor FUKUMURA Atsushi Etiology and clinical feature of acute hepatitis Assistant Professor MATSUE Yasuhiro Mechanism of liver cancer Assistant Professor MINATO Takahiro Mechanism of non-alcoholic steatohepatitis
Keywords of Research
alcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholic steatohepatitis, FLS-ob mouse, metabolic syndrome, insulin resistance, leptin, adiponectin, oxidative stress, anti-oxidative enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therary, chronic type B hepatitis, anti-viral treatment, treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis, regenerative medicine, stem cell, adipose tissue
Outline of Research
1 Basic and clinical study of digestive disease (1)Treatment for esophageal and gastric varices associated with portal hypertension (2)Hepatic support system for severe alcoholic hepatitis (3)Clinical feature and treatment for nonalcoholic steatohepatitis 2 Experimental study of alcoholic organ injury (1)Pathogenesis and treatment for alcoholic hepatitis (2)Pathogenesis of hepatic fibrosis induced by alcohol (3)Effect of alcohol on chemical carcinogenesis of the liver 3 Pathogenesis for nonalcoholic steatohepatitis 4 Regenerative medicine (1)Regenerative of hepatic cell (2)Regenerative of mucosa on esophagus and stomach (3)Development of sheet for stem cell
- 30 - Publications
Originals 0325B001 Toshikuni Nobuyuki, Tsuchishima Mutsumi, Fukumura Atsushi, Arisawa Tomiyasu, Tsutsumi Mikihiro:Associations of Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic and
Nonalcoholic Steatohepatitis, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2017:9127847, 2017.
0325B002 Toshikuni Nobuyuki:Therapy with Direct-Acting Antiviral Agents for Hepatitis C-Related Liver Cirrhosis, GUT
AND LIVER, 11:3;335-348, 2017.
0325B003 Toshikuni Nobuyuki, Matsue Yasuhiro, Ozaki Kazuaki, Yamada Kaho, Hayashi Nobuhiko, Tsuchishima Mutsumi, Tsutsumi Mikihiro:An image fusion system for estimating the therapeutic effects of radiofrequency ablation on
hepatocellular carcinoma, RADIOLOGY AND ONCOLOGY, 51:3;263-269, 2017.
0325B004 George Joseph, Tsutsumi Mikihiro, Tsuchishima Mutsumi:MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice, JOURNAL OF CELLULAR AND
MOLECULAR MEDICINE, 21:12;3821-3835, 2017.
Reviews 0325C001 Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi:Toxic AGE
(TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD, Nutrients, 9:634, 2017.
Presentations at Conference
International Conference (Presentations) 0325I001 J.George, N.Hayashi, T.Saito, K.Ozaki, N.Toshikuni, M.Tsuchishima, M.Tsutsumi:Nanovesicle mediated delivery of combination of anticancer agents effectively induced cell death in Hepatocellular carcinoma cell lines, International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver,
Amsterdam, 2017.04.
0325I002 Joseph George, Nobuhiko Hayashi, Takashi Saito, Kazuaki Ozaki, Nobuyuki Toshikuni, Mutsumi Tsuchishima, Mikihiro Tsutsumi:Deletion of survivin sensitize human hepatocellular carcinoma cells to low dose of doxorubicin
and induce apoptosis, AACR Annual Meeting 2017, Washington,D.C., 2017.04.
0325I003 Nobuyuki Toshikuni, Yasuhiro Matsue, Kazuaki Ozaki, Nobuhiko Hayashi, Mutsumi Tsuchishima, Mikihiro Tsutsumi:Real-Time Image fusion for estimating the therapeutic effects of radiofrequency ablation on hepatocellular carcinoma, Digestive Disease Week 2017, Chicago, 2017.05.
0325I004 Kaori Kinoshita, Nobuyuki Toshikuni, Mutsumi Tsuchishima, Mikihiro Tsutsumi:The effects of moderate drinking
on liver fibrosis progression in subjects with fatty liver disease, Digestive Disease Week 2017, Chicago, 2017.05.
0325I005 Joseph George, Nobuhiko Hayashi, Mutsumi Tsuchishima, Mikihiro Tsutsumi:Inhibition of γ-Glutamyl transpeptidase attenuates hepatic ischemia-reperfusion injury in rats, Digestive Disease Week 2017, Chicago,
2017.05.
- 31 - 0330 Department of Nephrology
Faculty
Title Name Field of Specialization Clinicopathological study of nephritic and nephrotic syndrome, Professor YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renal transplantation Senior Assistant Professor YAMAYA Hideki Clinical nephrology Senior Assistant Professor ADACHI Hiroki Clinical nephrology Senior Assistant Professor FUJIMOTO Keiji Clinical nephrology Assistant Professor IMURA Junko Clinical nephrology CHIKAZAWA Assistant Professor Clinical nephrology Yoshihiro Assistant Professor NAKAGAWA Masaru Clinical nephrology Assistant Professor MATSUI Yuki Clinical nephrology Assistant Professor HAYASHI Norifumi Clinical nephrology Assistant Professor OKINO Kazuaki Clinical nephrology Assistant Professor MUKAI Kiyotaka Clinical nephrology Assistant Professor OKUSHI Yuki Clinical nephrology Assistant Professor OKADA Keiichirou Assistant Professor NAKAYAMA Kanae MATSUURA Assistant Professor Toshikazu Assistant Professor KUBO Yukimi
Keywords of Research
acquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype, metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation, hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure, survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD
Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases (CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population. As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal works of various research fields.
- 32 - Publications
Originals 0330B001 (Saito T), Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S, Sasatomi Y, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y:Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous
nephropathy with steroid-resistant nephrotic syndrome, Clinical and Experimental Nephrology, 21:961-970, 2017.
0330B002 (Hiromura K), Ikeuchi H, Kayakabe K, Sugiyama H, Nagata M, Sato H, Yokoyama H, Nojima Y:Clinical and histological features of lupus nephritis in Japan: A cross-sectional analysis of the Japan Renal Biopsy Registry (J-
RBR), Nephrology (Carlton), 22:885-891, 2017.
0330B003 (Nishi S), Muso E, Shimizu A, Sugiyama H, Yokoyama H, Ando Y, Goto S, Fujii H:A clinical evaluation of renal amyloidosis in the Japan renal biopsy registry: a cross-sectional study, Clinical and Experimental Nephrology,
21:624-632, 2017.
0330B004 (Uemura O), Yokoyama H, Ishikura K, Gotoh Y, Sato H, Sugiyama H, Honda M, Matsuo S:Performance in adolescents of the two Japanese serum creatinine based estimated glomerular filtration rate equations, for adults and paediatric patients: A study of the Japan Renal Biopsy Registry and Japan Kidney Disease Registry from 2007
to 2013, Nephrology (Carlton), 22:494-497, 2017.
0330B005 Okushi Y, Okino K, Mukai K, Matsui Y, Hayashi N, Fujimoto K, Adachi H, Yamaya H, Yokoyama H:Circulating and renal expression of HLA-G prevented chronic renal allograft dysfunction in Japanese recipients, Clinical and
Experimental Nephrology, 21:932-940, 2017.
0330B006 K.Okino, Y.Okushi, K.Mukai, Y.Matsui, N.Hayashi, K.Fujimoto, H.Adachi, H.Yamaya:The long-term outcomes of hepatitis C virus core antigen-positive Japanese renal allograft recipients, Clinical and Experimental Nephrology,
21:1113-1123, 2017.
0330B007 (Ichikawa K), Konta T, Sato H, Ueda Y, Yokoyama H:The clinical and pathological characteristics of nephropathies in connective tissue diseases in the Japan Renal Biopsy Registry (J-RBR), Clinical and Experimental Nephrology,
21:1024-1029, 2017.
Case Reports 0330D001 Keiji Fujimoto, Masaru Nakagawa, Katsuaki Sato, Tatsuro Tanaka, Nobuhiko Miyatake, Keita Yamazaki, Yuko Tsuruyama, Yuki Okushi, Kazuaki Okino, Kiyotaka Mukai, Katsuhito Miyazawa, Hitoshi Yokoyama:A patient with tuberous sclerosis in whom dialysis was introduced due to hemorrhaging from oncocytic papillary renal cell
carcinoma, Journal of Japanese Society for Dialysis Therapy, 50:93-100, 2017.
Presentations at Conference
International Conference (Presentations) 0330I001 N.Hayashi, Y.Matsui, K.Fujimoto, H.Adachi, H.Yamaya, H.Yokoyama:Clinical impact of glomerular mannose- binding lectin deposition in intrinsic antigen-related membranous nephropathy, The Annual of American Sociey of
Nephrology, 2017.
- 33 - 0340 Department of Diabetology and Endocrinology
Faculty
Title Name Field of Specialization Professor KOYA Daisuke diabetes, hypertension, obesity, aging Associate Professor NAKAGAWA Atsushi diabetes, pituitary diseases Associate Professor KANASAKI Keizo diabetes, hypertenstion, obesity, preeclampsia Associate Professor KITADA Munehiro diabetes, diabetical renal disease, hypertension Senior Assistant Professor KONISHI Kazunori diabetes, hypertenstion, arteriosclerotic disease Assistant Professor WATANABE Ai diabetes Assistant Professor NITTA Kyouko diabetes
Keywords of Research
diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa, transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring, hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial gene mutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy
Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stress- induced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1 under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic complications. Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on the metabolic syndrome and blood pressure pattern to find out the participation of adiponectin. We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose homeostasis.
Books
0340A001 Daisuke Koya:Capter3 Patient assessment and diagnosis, Managing diabetic nephropathies in clinical practice, 47-
56, Adis, Cham, 2017.
Publications
Originals 0340B001 (Yasuhiro Onogi), Tsutomu Wada, Chie Kamiya, Kento Inata, Takatoshi Matsuzawa, Yuka Inaba, Kumi Kimura, Hiroshi Inoue, Seiji Yamamoto, Yoko Ishii, Daisuke Koya, Hiroshi Tsuneki, Masakiyo Sasahara, Toshiyasu Sasaoka:PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-
Induced Obesity, Diabetes, 66:4;1008-1021, 2017.
- 34 - 0340B002 (Shigehiro Katayama), Daishiro Yamada, Mikihiro Nakayama, Takashi Yamada, Masafumi Myoishi, Masaharu Kato, Christina Nowack, Peter Kolkhof, Yoshimitsu Yamasaki, on behalf of the ARTS-DN Japan Study Group:A randomized controlled study of finerenone versus placebo in Japanese patients with type 2 diabetes mellitus and
diabetic nephropathy, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 31:4;758-765, 2017.
0340B003 Hiroki Ito, Atsushi Nakagawa, Daisuke Koya:Reduced incretin effect in type 2 diabetes is mainly attributable to impaired glucose responsiveness of β-cells: evaluation via an oral sugar load under a hyperglycemic clamp, Journal
of Kanazawa Medical University, 42:1;7-16, 2017.
0340B004 Norikazu Ueki, Keizo Kanasaki, Megumi Kanasaki, Satoru Takeda, Daisuke Koya:Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II, Hypertension, 69:6;1156-
1164, 2017.
0340B005 Munehiro Kitada, Shin-ichi Tsuda, Kazunori Konishi, Ai Takeda-Watanabe, Mizue Fujii, Keizo Kanasaki, Makoto Nishizawa, Atsushi Nakagawa, Daisuke Koya:Anagliptin ameliorates albuminuria and urinary liver-type fatty acid- binding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent
manner, BMJ open diabetes research & care, 5:1;e000391, 2017.
0340B006 Jinpeng Li, Sen Shi, Swayam Prakash Srivastava, Munehiro Kitada, Takako Nagai, Kyoko Nitta, Miyuki Kohno, Keizo Kanasaki, Daisuke Koya:FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N- acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway, CELL DEATH & DISEASE, 8:e2965,
2017.
0340B007 Megumi Kanasaki, Swayam Prakash Srivastava, Fan Yang, Ling Xu, Sumiyo Kudoh, Munehiro Kitada, Norikazu Ueki, Hyoh Kim, Jinpeng Li, Satoru Takeda, Keizo Kanasaki, Daisuke Koya:Deficiency in catechol-o- methyltransferase is linked to a disruption of glucose homeostasis in mice, SCIENTIFIC REPORTS, 7:1;7927, 2017.
0340B008 Munehiro Kitada, Yoshio Ogura, Hiroko Maruki-Uchida, Masahiko Sai, Taeko Suzuki, Keizo Kanasaki, Yuna Hara, Hiromi Seto, Yuka Kuroshima, Itaru Monno, Daisuke Koya:The Effect of Piceatannol from Passion Fruit (Passiflora
edulis) Seeds on Metabolic Health in Humans, NUTRIENTS, 9:10;1142, 2017.
0340B009 (Per-Henrik Groop), Mark E Cooper, Vlado Perkovic, Berthold Hocher, Keizo Kanasaki, Masakazu Haneda, Guntram Schernthaner, Kumar Sharma, Robert C Stanton, Robert Toto, Jessica Cescutti, Maud Gordat, Thomas Meinicke, Audrey Koitka-Weber, Sandra Thiemann, Maximilian von Eynatten:Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: the randomized MARLINA-
T2D trial, DIABETES OBESITY & METABOLISM, 19:11;1610-1619, 2017.
0340B010 Munehiro Kitada, Yoshio Ogura, Taeko Suzuki, Itaru Monnno, Keizo Kanasaki, Ai Watanabe, Daisuke Koya:Cyclic and intermittent very low-protein diet can have beneficial effects against advanced diabetic nephropathy in Wistar
fatty (fa/fa) rats, an animal model of type 2 diabetes and obesity, NEPHROLOGY, 22:12;1030-1034, 2017.
0340B011 (Tsutomu Wada), Akari Ishikawa, Eri Watanabe, Yuto Nakamura, Yusuke Aruga, Hayate Hasegawa, Yasuhiro Onogi, Hiroe Honda, Yoshinori Nagai, Kiyoshi Takatsu, Yoko Ishii, Masakiyo Sasahara, Daisuke Koya, Hiroshi Tsuneki, Toshiyasu Sasaoka:Eplerenone prevented obesity-induced inflammasome activation and glucose
intolerance, JOURNAL OF ENDOCRINOLOGY, 235:3;179-191, 2017.
Reviews 0340C001 Yuta Takagaki, Daisuke Koya, Keizo Kanasaki:Dipeptidyl peptidase-4 inhibition and renoprotection: the role of
antifibrotic effects, CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 26:1;56-66, 2017.
0340C002 Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koya:Regulating Autophagy as a Therapeutic Target for
Diabetic Nephropathy, Current diabetes reports, 17:7;53, 2017.
0340C003 Keizo Kanasaki:DKD in elderly population, 75:11;1724-1732, 2017.
Short Communications 0340E001 Daisuke Koya:Impact of empagliflozin on diabetic kidney disease, JOURNAL OF DIABETES INVESTIGATION,
8:5;658-660, 2017.
- 35 - Presentations at Conference
International Conference (Key Note Lecture)
0340G001 Daisuke Koya:Luseogliflozin in T2DM manegement, Diabetes Asia 2017, Kuala Lumpur, 2017.
International Conference (Symposium) 0340H001 Yuta Takagaki, Keizo Kanasaki, Makoto Kato, Daisuke Koya:Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice, 2017 Asia Islet Biology & Incretin Symposium (AASD Affiliated
Symposium), Seoul, 2017.03.
0340H002 Keizo Kanasaki:Symposium II The pathological role of endothelial DPP-4 in diabetic kidney fibrosis, 2017 Asia Islet
Biology & Incretin Symposium (AASD Affiliated Symposium), Seoul, 2017.03.
0340H003 Daisuke Koya:Symposium 1 Autophagy & diabetes Autophagy protects against kidney injury related to aging, obesity and diabetes, 3rd Korea-Japan Diabetes Forum in conjunction with 30th Spring Congress of Korean
Diabetes Association, Busan, 2017.05.
0340H004 Daisuke Koya:Nutrition, inflammation & metabolism Beneficial effects of calorie restriction and protein dilution,
The 37th Annual Meeting of the Korean Society of Nephrology (KSN2017), Seoul, 2017.05.
0340H005 Daisuke Koya:Experience in diabetes management across countries A truly Asian real world evidence of SGLT2i,
Diabetes Asia 2017, Kuala Lumpur, 2017.10.
International Conference (Presentations) 0340I001 Y.Takagaki, S.M.Lee, D.Zha, K.Kanasaki, D.Koya:Atg5 deficiency in endothelial cells contributes to the development of IL-6 dependent endothelial to mesenchymal transition and kidney fibrosis, 53rd Annual Meeting of
the European Association for the Study of Diabetes (EASD 2017), Lisbon, 2017.
0340I002 O.Tachibana, Y.Hayashi, Y.Sasagawa, S.Takada, A.Tamase, S.Shiraga, K.Okamoto, A.Nakagawa, D.Koya, M.Nakada,H. Iiduka:The efficacy of intra-operative topical dexamethasone administration on the prevention of Rathke cleft cyst re-accumulation and recurrence, The 1st meeting of Japan-China Neurosurgery Alliance, The 9th
Neurosurgery Conference of China and Japan, Zhengzhou Dengfeng, 2017.
- 36 - 0350 Department of Hematology and Immunology
Faculty
Title Name Field of Specialization Professor MASAKI Yasufumi Hematology and Immunology, Transfusion Medicine Professor OKAZAKI Toshiro Hematology and Immunology, Hematology/Oncology FUKUSHIMA Professor Hematology and Immunology, Clinical Parmacology Toshihiro Professor KAWABATA Hiroshi Hematology, Iron metabolizm Associate Professor FUJITA Yoshimasa Rheumatology, Immunology Senior Assistant Professor KAWANAMI Takafumi Hematology and Immunology Senior Assistant Professor SAKAI Tomoyuki Hematology and Immunology Assistant Professor FUJIMOTO Shino Hematology and Immunology Assistant Professor HASHIZUME Chieko Hematology and Immunology Assistant Professor NAGAYA Shingo Hematology and Immunology
Keywords of Research
Sjogren's syndrome, malignant lymphoma, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, rheumatoid arthritis, systemic lupus erythematosus, TAFRO syndrome, Cattleman's disease, IgG4-related disease, proteomics, leptin, follicular dendritic cell,regeneration therapy
Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic research in the fields of Hematology and Immunology. 1, Clinico-pathological study of a new disease entity; TAFRO syndrome. 2, Pathophysiological analysis of IgG4-related disease. (1) Evaluation of CD14+cells in lymphoid follicle. (2) Proteomics analysis. (3) Lipid mediators and those balance . 3, Analysis of Leptin in patients with systemic autoimmune disorders. 4, Evaluation and regeneration therapy of salivary gland tissue in Sjogren's syndrome. 5, Clinical study for patients with intractable aggressive lymphomas. 6, Analysis of iron metabolism in hematological disorders.
Publications
Originals 0350B001 (Takaya Komori), Toshiaki Kogame, Takashi Nomura, Yo Kaku, Yuichiro Endo, Chiyuki Ueshima, Masahiro Hirata, Tatsuki R.Kataoka, Hiroshi Kawabata, Kenji Kabashima:Maculopapular rash during a nadir period in a patient with
acute myeloid leukaemia, European Journal of Dermatology, 27:3;316-317, 2017.
0350B002 (S.Sakamoto), H.Kawabata, J.Kanda, T.Uchiyama, C.Mizumoto, T.Kitano, T.Kondo, M.Hishizawa, N.Tomosugi, A.Takaori-Kondo:High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet
engraftment after allogeneic hematopoietic stem cell transplantation., Cancer medicine, 6:1;120-128, 2017.
- 37 - 0350B003 Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki, Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose, Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.
0350B004 (Katsuhiro Miura), Jun Konishi, Takaaki Miyake, Masanori Makita, Atsuko Hojo, Yasufumi Masaki, Masatoshi Uno, Jun Ozaki, Chikamasa Yoshida, Daigo Niiya, Koichi Kitazume, Yoshinobu Maeda, Jun Takizawa, Rika Sakai, Tomofumi Yano, Kazuhiko Yamamoto, Kazutaka Sunami, Yasushi Hiramatsu, Kazutoshi Aoyama, Hideki Tsujimura, Jun Murakami, Yoshihiro Hatta, Masatoshi Kanno:A host-dependent prognostic model for elderly patients with
diffuse large B-cell lymphoma, The Oncologist, 22:5;554-560, 2017.
0350B005 Hiroshi Kawabata, Kaoru Tohyama, Akira Matsuda, Kayano Araseki, Tomoko Hata, Takahiro Suzuki, Hidekazu Kayano, Kei Shimbo, Yuji Zaike, Kensuke Usuki, Shigeru Chiba, Takayuki Ishikawa, Nobuyoshi Arima, Masaharu Nogawa, Akiko Ohta, Yasushi Miyazaki, Kinuko Mitani, Keiya Ozawa, Shunya Arai, Mineo Kurokawa, Akifumi Takaori-Kondo, The Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes: Validation of the revised international prognostic scoring system in patients with myelodysplastic syndrome in
Japan: results from a prospective multicenter registry, International journal of hematology, 106:375-384, 2017.
0350B006 (Yoshinobu Maeda), Hisakazu Nishimori, Isao Yoshida, Hasushi Hiramatsu, Masatosh Uno, Yasufumi Masaki, Kazutaka Sunami, Taro Masunari, Yuichiro Nawa, Hiromichi Yamane, Hiroshi Gomyo, Tsutomu Takahashi, Tomofumi Yano, Keitaro Matsuo, Koichi Ohshima, Shigeo Nakamura, Tadashi Yoshino, Mitsune Tanimoto: Dose-abjusted EPOCH chemotherapy for untreated peripheral T-cell lymphomas: a multicenter phase Ⅱ trial of
West-JHOG PTCL0707, Haematologica, 102:12;2097-2103, 2017.
0350B007 Toshio Ohnishi, Chieko Hashizume, Makoto Taniguchi, Hidehiro Furumoto, Jia Han, Rongfen Gao, Shinichi Kinami, Takeo Kosaka, Toshiro Okazaki:Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer, The Faseb Journal, 31:9;3816-3830, 2017.
Reviews 0350C001 (Junithci Kitazawa), Yoshiko Tamai, Hiroshi Fujita, Shigeyoshi Makino, Yasufumi Masaki, Eijiro Omoto, Hidetaka Oda, Hiroshi Nakamura, Toshihiko Futagi, Yuu Kuroda, Naoki Tachibana, Masanori Matsumoto, Tadashi
Matsushita:Red cell transfusion in home, Japanese Journal of Transfusion and Cell Therapy, 63:5;664-773, 2017.
0350C002 (Tomohiro Koga), Shino Fujimoto, Astushi Kawakami, Hiroshi Kawabata, Yasufumi Masaki, Tadamitsu Kishimoto Kazuyuki Yoshizaki:Therapeutic outlook for Castleman's disease: prospects for the next decade, EXPERT
OPINION ON ORPHAN DRUGS, 5:8;633-640, 2017.
0350C003 Yoshimasa Fujita:Leptin and autoimmune disease, Japanese Journal of Clinical Immunology, 40:3;155-159, 2017.
0350C004 Yasufumi Masaki, Shino Fujimoto, Haruka Kawanami-Iwao, Tomoyuki Sakai, Takafumi Kawanami, Yopshimasa Fujita, Hiroshi Kawabata, Toshihiro Fukushima:The treatment strategy of IgG4-related disease - from the result of
prospective clinical study -, 29:2;140-146, 2017.
0350C005 Hiroshi Kawabata:Progress in iron metabolism research, Rinsho Ketsueki, 58:10;1864-1871, 2017.
Case Reports 0350D001 Shino Fujimoto, Hiroshi Kawabata, Nozomu Kurose, Haruka Kawanami-Iwao, Tomoyuki Sakai, Takafumi Kawanami, Yoshimasa Fujita, Toshihiro Fukushima, Yasufumi Masaki: Sjögren's syndrome manifesting as clinicopathological features of TAFRO syndrome, Medicine, 96;e9220,2017. 0350D002 (Toshimitsu Ueki), Masaru Nasu, Hiroko Kaiume, Yuki Hiroshima, Masahiko Sumi, Masahide Watanabe, Dai Inoue, Yasufumi Masaki, Yasuharu Sato, Masaru Kojima, Hikaru Kobayashi:Multicentric Castleman's disease with multiple
hepatic mass lesions mimicking malignant liver tumors, Rinsho Ketsueki, 58:6;630-636, 2017.
Short Communications 0350E001 Hiroshi Kawabata:Overview, Rinsho Ketsueki, 58:4;327-328, 2017.
- 38 - Others 0350F001 (Yataro Yoshida), Tatsuya Katsurada, Yukiharu Nakabou, Hiroshi Kawabata:Efficacy of interferon-alpha in essential
thrombocythemia during pregnancy, Annals of Hematology, 96:877-878, 2017.
Presentations at Conference
International Conference (Key Note Lecture) 0350G001 Toshiro Okazaki:Inhibition of acute colitis and hepatic infiltration malignant cells by SMS2 deficiency, Key note
speaker at 8th international Ceramide Conference, New York, 2017.05.
0350G002 Toshiro Okazaki, Chieko Hashizume, Makoto Taniguchi, Takeo Kosaka:Role of sphingomyeline synthase 2 (SMS2) in murine colitis and colon cancer, 3rd International Conference on New Horizons of Basic nd Applied Science,
Hurghada, 2017.08.
0350G003 Toshiro Okazaki:Ceramid increase by deficiency of sphingomyelin synthase (SMS) 2 suppressed murine acute colitis and colon cancer initiation through cytokine/chemokine inhibition, Bioactive Lipids in Cancer,Inflammation
&Related Diseases, 15th international conference, Puerto Vallarta, Mexico, 2017.10.
- 39 - 0360 Department of Neurology
Faculty
Title Name Field of Specialization Professor MATSUI Makoto Clinical neurology, Neuroimmunology, Clinical Immunology Associate Professor NAGAYAMA Shigemi Clinical neurology, Neuroimmunology Associate Professor SANADA Mitsuru Clinical neurology, Neurophysiology Senior Assistant Professor NAKANISHI Megumi Clinical neurology, Neuroimmunology Assistant Professor FUJITA Michiyo Clinical neurology Assistant Professor OONO Miki Clinical neurology
Keywords of Research
clinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes, autoantibody, neuroimmunology, neuroinfection, experimental autoimmune encephalomyelitis,
Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animal models, which have been established due to recent advances in basic immunology.
Publications
Originals 0360B001 (Shigeaki Suzuki), Nobuhisa Ishikawa, Fumie Konoeda, Nobuhiko Seki, Satoshi Fukushima, Kikuko Takahashi, Hisashi Uhara, Yoshikazu Hasegawa, Shinichiro Inomata, Yasushi Otani, Kenji Yokota, Takashi Hirose, Ryo Tanaka, Norihiro Suzuki, Makoto Matsui:Nivolumab-related myasthenia gravis with myositis and myocarditis in
Japan, Neurology, 89:1127-1134, 2017.
0360B002 (Yuko Yamagishi), Hidekazu Suzuki, Masahiro Sonoo, Satoshi Kuwabara, Takanori Yokota, Kyoichi Nomura, Atsuro Chiba, Ryuji Kaji, Takashi Kanda, Kenishi Kaida, Shu-ichi Ikeda, Tatsuro Mutoh, Ryo Yamazaki, Hiroshi Takashima, Makoto Matsui, Kazutoshi Nishiyama, Gen Sobue, Susumu Kusunoki:Markers for Guillain-Barre
syndrome with poor prognosis:a multi-center stydy, Journal of the Peripheral Nervous System, 22:433-439, 2017.
0360B003 (Masaaki Niino), Toshiyuki Fukazawa, Jun-ichi Kira, Tatsusada Okuno, Masahiro Mori, Nobuo Sanjyo, Takashi Ohashi, Hikoaki Fukaura, Juichi Fujimori, Yuko Shimizu, Nobuhiro Mifune, Yusei Miyazaki, Eri Takahashi, Seiji Kikuchi, Dawn Langdon, RaIph HB Benedict, Makoto Matsui:Validation of the Brief International Cognitive Assessment for Multiple Selerosis in Japan, Multiple Sclerosis Journal Experimental ,Translational Clinical,
3:4;2055217317748972, 2017.
Reviews 0360C001 Makoto Matsui:How to use the new 2017 Japanese guidelines for multiple sclerosis and neuromyelitis optica,
Clinical and Experimental Neuroimmunology, 8:351-360, 2017.
0360C002 Mitsuru Sanada:Vascular endothelial function test, The Autonomic Nervous System, 54:234-237, 2017.
- 40 - Case Reports 0360D001 Megumi Nakanishi, Nobuaki Uchida, Ukichiro Kawai, Miki Oono, Michiyo Fujita-Nakata, Mitsuru Sanada, Shigemi Nagayama, Makoto Matsui:A case of Mumps Virus Reinfection Manifesting as Severe Meningitis that Mimicked
Tuberculous Meningitis, Journal of Neuroinfectious Diseases, 8:2, 2017.
- 41 - 0363 Department of Medical Oncology
Faculty
Title Name Field of Specialization Professor MOTOO Yoshiharu Medical Oncology, Tumor Cell Biology, Gastroenterology Professor YASUMOTO Kazuo Gastric cancer, Cancerous peritonitis molecular target therapy Senior Assistant Professor HISAMURA Kazuho Social Work, Social Welfare, Psycho-Oncology Assistant Professor KASAI Suguru Medical Oncology
Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology,
Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperating with Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include the metabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the discovery of new molecular markers for pancreatic cancer.
Publications
Originals 0363B001 Ippei Chikazawa, Shinya Inoue, Yusuke Nakazawa, Dan Nakai, Nobuyo Morita, Tatsuro Tanaka, Yoshiharu Motoo, Katsuhito Miyazawa:Clinical study on the efficacy and continuous docetaxel based chemotherapy treatment for
castration-resistant prostate cancer, 63:9;351-357, 2017.
0363B002 (Keiko Yukawa), Hirono Ishikawa, Yoshihiko Yamazaki, Jimpei Misawa, Kiichiro Tsutani, Ichiro Arai, Yoshiharu Motoo, Takahiro Kiuchi:Economic burden and mental distress in using complementary and alternative medicine, and formal supports by medical professional of japanese patients with chronic diseases, Japanese Pharmacology & Therapeutics, 45:3;345-355, 2017.
0363B003 Y Motoo, T Hakamatsuka, N Kawahara, I AraiI, K Tsutani:Standards of reporting Kampo products (STORK) in
research articles, Journal of Integrative Medicine, 15:3;182-185, 2017.
0363B004 (Suzuki Toshiaki), Yamamoto Ayano, Ohsawa Masahiro, Motoo Yoshiharu, Mizukami Hajime, Makino Toshiaki: Effect of ninjin'yoeito and ginseng extracts on oxaliplatin-induced neuropathies in mice, Journal of Natural
Medicines, 71:4;757-764, 2017.
0363B005 Yuko Matsui, Ryoko Murayama, Hidenori Tanabe, Makoto Oe, Yoshiharu Motoo, Takanori Wagatsuma, Michiko Michibuchi, Sachiko Kinosita, Keiko Sakai, Chizuko Konya, Junko Sugama, Hiromi Sanada:Evaluation of the predictive validity of thermography in identifying extravasation with intravenous chemotherapy infusions, Journal of
Infusion Nursing, 40:6;367-374, 2017.
0363B006 (Kita Kenji), Arai Sachiko, Nishiyama Akihiro, Taniguchi Hirokazu, Fukuda Koji, Wang Rong, Yamada Tadaaki, Takeuchi Shinji, Tange Shoichiro, Tajima Atsushi, Nakada Mitsutoshi, Yasumoto Kazuo, Motoo Yoshiharu, Murakami Takashi, Yano Seiji:In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of
targeted drugs, Cancer Medicine, 6:12;2972-2983, 2017.
- 42 - Reviews 0363C001 Yoshiharu Motoo:Gastrointestinal adverse effects and their management in molecular targeting therapy, Nippon
Rinsho, 75:9;1425-1429, 2017.
Case Reports 0363D001 Nobuhiko Ueda, Yoritaka Fujii, Seiko Miura, Jun Fujita, Yasuto Tomita, Toshio Ohnishi, Hideto Fujita, Shinichi Kinami, Kazuhiko Omote, Yasuharu Nakano, Takeo Kosaka, Yoshiharu Motoo:Long-term survival due to combination therapy in a patient with locally advanced body-tall pancreatic cancer, Japanese Journal of Cancer and
Chemotherapy, 44:12;1373-1375, 2017.
Presentations at Conference
International Conference (Symposium) 0363H001 Y Motoo:Standards of Reporting Kampo Products (STORK) in research articles., The 4th International Symposium
of Japanese Kampo Medicine (ISJKM), Berlin, 2017.05.
0363H002 Y Motoo:Chemotherapy Support Team (CST) and Kampo, 12th International Congress of Complementary Medicine
and Research (ICCMR), Berlin, 2017.05.
International Conference (Presentations) 0363I001 K Yasumoto, A Kawashima:The characteristics of cancer stroma in the development of scirrhous gastric cancer,
The 5th Annual Meeting of the International Cytokine & Interferon Society "Cytokine 2017", Kanazawa, 2017.10.
- 43 - 0366 Department of Infectious Diseases
Faculty
Title Name Field of Specialization Professor IINUMA Yoshitsugu Clinical Infectious Diseases, Infection Control and Prevention Associate Professor KAWAI Yasuhiro Clinical Infectious Diseases, Infection Control and Prevention Assistant Professor USUDA Daisuke Clinical Infectious Diseases, Infection Control and Prevention
Keywords of Research
Infectious diseases, Antimicrobial drug resistance, Immunocompromised host, Acid-fast bacilli, Antimicrobial drugs,
Outline of Research
1. Antimicrobial drug resistant bacilli infections 2. Infectious diseases in severe immunocompromised host 3. Acid-fast bacilli infections 4. Appropriate use of antimicrobial drugs
Publications
Originals 0366B001 Noda Yoko, Iinuma Yoshitsugu, Usuda Daisuke, Taga Mitsutoshi, Shinmachi Miyuki, Maeda Kazumi, Maeno Toshiko:Revising the Hygiene Maintenance of Urine Disposal Facilitated the Appropriate Indication of Urine Collection, Japanese Journal of Environmental Infections, 32:1;23-28, 2017.
0366B002 Aya Hashimoto, Yoshi Tanaka, Masami Matsumoto, Katsuhiro Nagata, Shizuyo Nakagawa, Yoshitame Yanaida, Yoshitsugu Iinuma:Evaluation of fully automated urine particle analyzer sysmex UF-5000, Japanese Journal of
Medical Technology, 66:3;255-265, 2017.
0366B003 Kawamura Kae, Iinuma Yoshitsugu, Usuda Daisuke, Hashimoto Aya, Matsumoto Masami, Tanaka Yoshi:Evaluation of automated urine particle analyzer, UF-5000, as a screening tool to identify Gram stainability of urinal pathogens, Japanese Journal of Medical Technology, 66:5;516-523, 2017.
0366B004 Y.Tanaka, M.Matsumoto, M.Yasui, R.Hokama, H.Takehara, Y.Itose, Y.Iinuma:Performance Evaluation of the Semi-
Automated Urine Chemistry Analyzer UC-1000, Sysmex Journal International, 27:1, 2017.
Reviews
0366C001 Yoshitsugu Iinuma:Infection prevention medical fees and microbiology laboratory, 63:10;255-261, 2017.
Case Reports 0366D001 Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda:Gastroenteritis in Japanese Females Caused by Shigella flexneri without Definite. Infection Route: A Case Report and Mini-Review of Literature, Journal Clinical Case Reports,
7:9;10001021, 2017.
0366D002 A.Takamura, R.Sangen, Y.Furumura, D.Usuda, Y.Kasamaki, T.Kanda:Diagnosis of myxedema coma complicated by
renal failure: a case report, Clinical Case Reports, 5:4;399-402, 2017.
0366D003 Daisuke Usuda, Masahisa Arahata, Kento Takeshima, Ryusho Sangen, Akiteru Takamura, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma, Tsugiyasu Kanda:A Case of Diffuse Large B-Cell Lymphoma Mimicking Primary
Effusion Lymphoma-Like Lymphoma, Case Reports in Oncology, 10:1013-1022, 2017.
- 44 - Others
0366F001 Yoshitsugu Iinuma:Occupational Health Program in Clinical Laboratory, Rinsho Byori, 65:4;419-423, 2017.
0366F002 Yoshitsugu Iinuma:Practical Use of Biomarkers for Supporting Diagnosis and Treatment of Infectious Diseases,
Rinsho Byori, 65:4;419-423, 2017.
- 45 - 0368 Department of General Internal Medicine
Faculty
Title Name Field of Specialization Lifestyle-related disease, Diabetes, Laboratory medicine, General Professor KOBAYASHI Junji medicine Professor FURUTA Hisakazu Sleep-wake disorders Associate Professor AKAZAWA Sumiyo gender specific medicine, hypertension, molecular biology Associate Professor UENISHI Hiroaki Cardiovascular Medicine Associate Professor TSUDA Ryosuke Exercise physiology, Pedagogy of physical education (Additional Post) Senior Assistant Professor MORIYA Junji General medicine, Kampo medicine Assistant Professor SAWADA Mio Kanpo medicine, Women medical care Assistant Professor YAMASAKI Naruhiro
Keywords of Research
neurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection
Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.
Publications
Originals 0368B001 (Hirokazu Kakuda), Junji Kobayashi, Masaru Sakurai, Masahiro Kakuda, Noboru Takekoshi:The effect of tofogliflozin treatment on postprandial glucose and lipid metabolism in Japanese men with type 2 diabetes: A pilot
study, Journal of clinical medicine research, 9:5;403-409, 2017.
0368B002 (Nobuyoshi Ishiyama), Kouji Sakamaki, Younosuke Shimomura, Kazuhiko Kotani, Kokoro Tsuzaki, Naoki Sakane, Kazuya Miyashita, Isao Fukamachi, Junji Kobayasi, Kimber L Stanhope, Peter J Havel, Keiko Kamachi, Akira Tanaka, Yoshiharu Tokita, Tethuo Machida, Masami Murakami, Katsuyuki Nakajima:Lipoprotein lipase dose not
increase significantly in the postprandisl plasma, Clinica Chimica Acta, 464:204-210, 2017.
0368B003 (Hayato Tada), Masaaki Kawashiri, Atsushi Nohara, Akihiro Inazu, Junji Kobayasi, Kenji Yasuda, Hiroshi Mabuchi, Masakazu Yamagishi, Kenshi Hayashi:Lipid Management in a Japanese Community:Attainment Rete of Target Set by the Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases
2012, Journal of atherosclerosis and thrombosis, 24:338-345, 2017.
0368B004 (Kazuya Miyashita), Katsuyuki Nakajima, Isamu Fukamachi, Yuji Murada, Takafumi Koga, Yohnosuke Shimomura, Tetsuyo Machida, Masami Murakami, Junji Kobayasi:A new enzyme-linked immunosorbent assay system for human
serum hepatic triglyceride lipase, JOURNAL OF LIPID RESEARCH, 58:1591-1597, 2017.
0368B005 Hirokazu Kakuda, Junji Kobayashi, Masaru Sakurai, Noboru Takekoshi:The Effects of Tofogliflozin on Glucose
Metabolism and Uric Acid, Progress in Medicine, 37:10;1219-1223, 2017.
- 46 - Reviews 0368C001 (Katsuyuki Nakajima), Yoshiharu Tokita, Koji Sakamaki, Younosuke Shimomura, Junji Kobayasi, Keiko Kamachi, Akira Tanaka, Kimber L Stanhope, Peter J Havel, Tao Wang, Tetsuo Machida, Masami Murakami:Triglyceride content in remnant lipoproteins is significantiy increased after food intake and is associated with plasma lipoprotein
lipase, Clinica Chimica Acta, 23:29;5364-5370, 2017.
Presentations at Conference
International Conference (Presentations) 0368I001 Ryosuke Tsuda:Results of a soccer teaching program intended to help students improve and acquire knowledge of
physical fitness, The 22nd annual Congress of the European College of Sport Science (ECSS), Essen, 2017.07.
- 47 - 0370 Department of Geriatric Medicine
Faculty
Title Name Field of Specialization Geriatrics, Hypertension, Calcium Metabolism, Dementia, Professor MORIMOTO Shigeto Osteoporosis Professor NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis Professor(Additional Post) IWAI Kunimitsu Geriatrics, Circulation, Cell Biology, Cardiology Associate Professor OKURO Masashi Geriatrics, Circulation, Hypertension, Atherosclerosis Senior Assistant Professor IRITANI Osamu Geriatrics, Circulation Assistant Professor MORITA Takuro Geriatrics, Circulation Assistant Professor YANO Hiroshi Geriatrics, Circulation Assistant Professor OKUNO Tazuo Geriatrics, Circulation Assistant Professor HIMENO Taro Geriatrics, Circulation HIGASHIKAWA Assistant Professor Gerontology Toshihiro
Keywords of Research
elderly, cardiac function, pneumoia, frailty, stroke, hypertension, antihypertensive treatment, isolated systolic hypertension, nutrition, dysphagia, diabetes mellitus, cardiac disease, atherosclerosis, dementia, depression, Hasegawa’s dementia scale, mini-mental state examination, eicosapentaenoic acid, osteoporosis,
Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acute diseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and of elderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using culture of arterial cells.
Publications
Originals 0370B001 Okuno Tazuo, Watanabe Keisuke, Nakajima Kumie, Iritani Osamu, Yano Hiroshi, Morita Takuro, Himeno Taroh, Igarashi Yuta, Okuro Masashi, Morimoto Shigeto:Major electrocardiographic abnormality predicts support/care- need certification and/or death in community-dwelling older adults with no history of cardiovascular disease.,
Geriatrics & gerontology international, 17:1967-1976, 2017.
0370B002 Morita Takuro, Okuno Tazuo, Himeno Taroh, Watanabe Keisuke, Nakajima Kumie, Koizumi Yumi, Yano Hiroshi, Iritani Osamu, Okuro Masashi, Morimoto Shigeto:Glycemic control and disability-free survival in hypoglycemic agent-treated community-dwelling older patients with type 2 diabetes mellitus., Geriatrics & gerontology
international, 17:1858-1865, 2017.
- 48 - 0380 Department of Pediatrics
Faculty
Title Name Field of Specialization Professor SAIKAWA Yutaka Pediatric hematology, Pediatric oncology NAKAMURA Associate Professor Pediatric cardiology Tsuneyuki Pediatric endocrinology, Pediatric metabolism, Inborn errors of Senior Assistant Professor ITOH Masatsune metabolism Infectionus disease in children, Moleculer biology, Child neurology, Senior Assistant Professor SATO Hitoshi Inborn errors of metabolism Senior Assistant Professor FUJIKI Takuma Pediatric Nephrology Senior Assistant Professor OKADA Naoki Pediatric hematology, Pediatric oncology Senior Assistant Professor KOBAYASHI Azusa Neonatology Senior Assistant Professor NAKAMURA Toshimi Pediatric allergy, Pediatric immunology Assistant Professor AKITA Chisato Pediatric cardiology Assistant Professor OGURI Masato Pediatric cardiology. Assistant Professor IKENO Kanjyu Child neurology Assistant Professor KITTAKA Yuko Pediatric allergy, Pediatric endocrinology Assistant Professor OKAMOTO Nobuhiro Pediatric cardiology Assistant Professor TOKI Shin Pediatric allergy Assistant Professor SHIMIZU Yo Fetology Assistant Professor FUJISAWA Reiko Pediatric hematology, Pediatric oncology
Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism, leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood,
Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.
Publications
Originals 0380B001 (Hideo Sasai), Yuka Aoyama, Hiroki Otsuka, Elsayed Abdelkreem, Yasuhiro Naiki, Mitsuru Kubota, Yuji Sekine, Masatsune Itoh, Mina Nakama, Hidenori Ohnishi, Ryoji Fujiki, Osamu Ohara, Toshiyuki Fukao:Heterozygous carriers of succinyl-CoA:3-oxoacid CoA transferase deficiency can develop severe ketoacidosis, Journal of
Inherited Metabolic Disease, 40:845-852, 2017.
- 49 - Case Reports 0380D001 Masatsune Itoh, Yutaka Saikawa:A novel MEN1 mutation in a Japanese adolescent with multiple endocrine
neoplasia type 1, Clinical pediatric endocrinology, 26:25-28, 2017.
0380D002 Chisato Akita, Yutaka Saikawa:Gastric Gyri - Pediatric Menetrier’s Disease, The New England Journal of
Medicine, 376:8;774, 2017.
0380D003 Shin Toki, Masatsune Itoh, Nobuhiro Okamoto, Azusa Kobayashi, Kentaro Yamada, Yuzo Shimode, Hiroyuki Tsuji, Takeo Shibata, Toshiyuki Sasagawa, Yutaka Saikawa:Multidisciplinary management of multiple endocrine neoplasia
type 1 during pregnancy, 53:3;905-908, 2017.
0380D004 Chisato Akita, Naoki Okada, Hitoshi Sato, Mondo Kuruda, Akihiro Yachie, Yutaka Saikawa:Eary biological markers
and cytokine profiles in a case of hemorrhagic shock and encephalopathy syndrome, 16:3;474-478, 2017.
Presentations at Conference
International Conference (Presentations) 0380I001 Hitoshi Sato, Atsushi Ishii, Chisato Akita, Kanju Ikeno, Yo Niida, Sawako Yamazaki, Shinichi Hirose, Hiroaki Kakinuma, Yutaka Saikawa:A case with severe recurrent attacks of hemiplegic migraine mimicking acute
encephalopathy, 14th Asian and Oceanian Congress of Child Neurology, Fukuoka, 2017.05.
- 50 - 0390 Department of Neuropsychiatry
Faculty
Title Name Field of Specialization Cognitive neurosciences, Neuropsychology, Neuroimaging, Professor KAWASAKI Yasuhiro Psychopharmacology, Neurophysiology Associate Professor UEHARA Takashi Neuropharmacology Senior Assistant Professor WATANABE Kenichiro Neuropsychology, Neuropharmacology Psychiatry, Genetics, Neuropsychopharmacology, Biological Senior Assistant Professor OHI Kazutaka Psychiatry, Imaging Senior Assistant Professor KITAMOTO Fukumi Psychotherapy, Clinical Psychology Assistant Professor NITTA Yusuke Consultation liaison psychiatry Assistant Professor HASHIMOTO Reiko Psychotherapy, Clinical Psychology Assistant Professor KIHARA Hiroaki Brain imaging,，Schizophrenia Assistant Professor SHIMADA Takamitsu Brain imaging,，Schizophrenia Assistant Professor OKUBO Hiroaki Psychiatry, Neurophysiology Assistant Professor YASUYAMA Toshiki
Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict, anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma, attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging, rTMS
Outline of Research
1.Study on regional identification of brain language areas by functional MRI―application for surgical therapy of epilepsy 2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT 3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal experiments 4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia 5.Clinical study on psychiatric disturbance in epilepsy 6.Study on cognitive-behavioural therapy for obsessive compulsive disorder 7.Study on music therapy for dementia 8.Study on repetitive transcranial magnetic stumilation for depression
Publications
Originals 0390B001 Ohi Kazutaka, Shimada Takamitsu, Nemoto Kiyotaka, Kataoka Yuzuru, Yasuyama Toshiki, Kimura Kohei, Okubo Hiroaki, Uehara Takashi, Kawasaki Yasuhiro:Cognitive clustering in schizophrenia patients, their first-degree relatives and healthy subjects is associated with anterior cingulate cortex volume, NeuroImage. Clinical, 16:248-
256, 2017.
0390B002 K.Ohi, T.Shimada, Ｔ.Yasuyama, H.Kihara, T.Uehara, Y.Kawasaki:Variability of 128 schizophrenia-associated gene
variants across distinct ethnic populations, Translational Psychiatry, 7:1-6, 2017.
- 51 - 0390B003 T.Yasuyama, K.Ohi, T.Shimada, T.Uehara, Y.Kawasaki:Differences in social functioning among patients with major psychiatric disorders: Interpersonal communication is impaired in patients with schizophrenia and correlates with
an increase in schizotypal traits., Psychiatry research, 249:30-34, 2017.
0390B004 Y.Ryo, M.Takeuchi, N.Ueda, K.Ohi, H.Kihara, T.Shimada, T.Uehara, Y.Kawasaki:Olfactory function in
neuropsychiatric disorders, PSYCHIATRY RESEARCH, 252:175-179, 2017.
0390B005 K.Ohi, T.Shimada, H.Kihara, T.Yasuyama, K.Sawai, Y.Matsuda, K,Oshima, H.Okubo, Y.Nitta, T.Uehara, Y.Kawasaki:Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared
Spectroscopy (NIRS) Study, Scientific Reports, 7:44268, 2017.
0390B006 (T.Omi), H.Ito, K.Riku, K.Kanai, H.Takada, S.Fujimi, H.Matsunaga, K.Ohi:Possible factors influencing the duration of hospital stay in patients with psychiatric disorders attempting suicide by jumping, BMC Psychiatry,
17:1;99, 2017.
0390B007 Ohi Kazutaka, Shimada Takamitsu, Yasuyama Toshiki, Kimura Kohei, Uehara Takashi, Kawasaki Yasuhiro:Spatial and temporal expression patterns of genes around nine neuroticism-associated loci, PROGRESS IN NEURO-
PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 77:164-171, 2017.
0390B008 Naoki Hashimoto, Yoichi M. Ito, Naohiro Okada, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Noriko Kudo, Ariyoshi Takemura, Shuraku Son, Hisashi Narita, Maeri Yamamoto, Khin Khin Tha, Asuka Katsuki, Kazutaka Ohi, Fumio Yamashita, Shinsuke Koike, Tsutomu Takahashi, Kiyotaka Nemoto, Masaki Fukunaga, Toshiaki Onitsuka, Yoshiyuki Watanabe, Hidenori Yamasue, Michio Suzuki, Kiyoto Kasai, Ichiro Kusumi, Ryota Hashimoto, for COCORO:The effect of duration of illness and antipsychotics on subcortical volumes in
schizophrenia: Analysis of 778 subjects, NeuroImage. Clinical., 17:563-569, 2017.
0390B009 Ohi Kazutaka, Sumiyoshi Chika, Fujino Haruo, Yasuda Yuka, Yamamori Hidenaga, Fujimoto Michiko, Sumiyoshi Tomiki, Hashimoto Ryota:A Brief Assessment of intelligence Decline in Schizophrenia As Represented by the
Difference between Current and Premorbid intellectual Quotient, FRONTIERS IN PSYCHIATRY, 8:293, 2017.
Case Reports 0390D001 Masao Ogawa, Michiko Michibuchi, Takanori Wagatsuma, Mikako Nishikawa, Yasuhiro Kawasaki, Hideaki Tsuchida, Kanako Teraguchi:A Case Whose Delirium Improved with Discontinuation of Continuous Deep Sedation
Initiated for Refractory Delirium at the End Stage of Cancer, Palliative Care Research, 12:1;501-505, 2017.
0390D002 Ohi Kazutaka, Kuwata Aki, Shimada Takamitsu, Yasuyama Toshiki, Nitta Yusuke, Uehara Takashi, Kawasaki Yasuhiro:Response to benzodiazepines and the clinical course in malignant catatonia associated with schizophrenia: A case report., Medicine, 96:16;e6566, 2017.
Presentations at Conference
International Conference (Presentations) 0390I001 K.Ohi, T.Shimada, T.Yasuyama, T.Uehara, Y.Kawasaki:Variability of 128 Schizophrenia-Associated Gene Variants
across Distinct Ethnic Populations, 5thAsian College of Neuropsychopharmacology 2017, Bali, 2017.04.
0390I002 T.Shimada:Differences in social functioning among patients with major psychiatric disorders: Interpersonal communication is impaired in patients with schizophrenia and correlates with an increase in schizotypal traits,
5thAsian College of Neuropsychopharmacology 2017, Bali, 2017.04.
0390I003 T.Shimada, K.Ohi, T.Yasuyama, T.Uehara, Y.Kawasaki:Differences in social functioning among patients with major psychiatric disorders: Interpersonal communication is impaired in patients with schizophrenia and correlates with
an increase in schizotypal traits, 13th World Congress of Biological Psychiatry, Copenhagen, 2017.06.
0390I004 K.Ohi, T.Shimada, T.Yasuyama, K.Sawai, K.Oshima, H.Okubo, Y.Nitta, T.Uehara, Y.Kawasaki:Impact of familial loading on prefrontal activation in major psychiatric disorders: A Near-Infrared Spectroscopy (NIRS) study , 13th
World Congress of Biological Psychiatry, Copenhagen, 2017.06.
0390I005 K.Ohi, T.Shimada, T.Yasuyama, T.Uehara, Y,Kawasaki:Variability of 128 Schizophrenia-Associated Gene Variants
across Distinct Ethnic Populations., 13th World Congress of Biological Psychiatry, copenhagen, 2017.06.
- 52 - 0390I006 Y. Kawasaki, K. Ohi, T. Shimada, T. Uehara, Y. Nitta, H. Kihara, H. Okubo:Investigation of disturbed functional connectivity related to mental disorders using independent component analysis., International Conference on Basic
and Clinical Multimodal Imaging, Bern, 2017.08.
- 53 - 0400 Department of Radiology
Faculty
Title Name Field of Specialization Professor MATOBA Munetaka Interventional Radiology, Diagnostic Imaging、Radiation therapy Professor WATANABE Naoto Nuclear Medicine Professor TONAMI Hisao Head and Neck Radiology, MRI Diagnosis Senior Assistant Professor TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging Senior Assistant Professor DOAI Mariko Diagnostic Imaging Assistant Professor OTA Kiyotaka Radiation Therapy，Nuclear Medicine Assistant Professor KONDO Tamaki Diagnostic Imaging Assistant Professor TSUCHIYA Naoko Diagnostic Imaging Assistant Professor TOYOTA Ichiro Diagnostic Imaging Assistant Professor OISO Kazumasa Diagnostic Imaging Assistant Professor NAKAJIMA Kento Diagnostic Imaging
Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery, brachitherapy, PEI, Sjogren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic stent, contrast medium,
Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy and Transarterial Embolization using MD-CT, MRI and MRS. 2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET. 3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy Planning System. 4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.
Publications
Originals 0400B001 Shiga Hideaki, Taki Junichi, Okuda Koichi, Watanabe Naoto, Tonami Hisao, Nakagawa Hideaki, Kinuya Seigo, Miwa Takaki:Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients
with idiopathic olfactory dysfunction., Scientific reports, 7:1;3581, 2017.
0400B002 Masataka Kitadate, Ichiro Toyota, Munetaka Matoba, Hisao Tonami:"Gun grip"Central venous puncture method,
Journal of Kanazawa Medical University, 42:1-6, 2017.
0400B003 Tsuchiya Naoko, Doai Mariko, Usuda Katsuo, Uramoto Hidetaka, Tonami Hisao:Non-small cell lung cancer: Whole-lesion histogram analysis of the apparent diffusion coefficient for assessment of tumor grade, lymphovascular
invasion and pleural invasion., PloS one, 12:2;e0172433, 2017.
0400B004 (Kotaro Higashi), Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki , Yuka Nakamura, Manabu Oguchi, Tsutomu Takegami, Naoto Watanabe.:High FDG uptake on PET is associated with negative cell-to-cell adhesion
molecule E-cadherin expression in lung adenocarcinoma., Annals of nuclear medicine, 31:590-595, 2017.
- 54 - 0400B005 Usuda Katsuo, Funazaki Aika, Maeda Ryo, Sekimura Atsushi, Motono Nozomu, Matoba Munetaka, Uramoto Hidetaka:Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging for
Primary Lung Cancer, Annals of Thoracic and Cardiovascular Surgery, 23:6;275-280, 2017.
0400B006 Y.Nakano, M.Noguchi, M.Yokoi-Noguchi, Y.Ohno, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of 18F-FDG-PET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients.,
Breast cancer, 24:1;121-127, 2017.
0400B007 Matoba Munetaka, Tuji Hiroyuki, Shimode Yuzo, Kondo Tamaki, Oota Kiyotaka, Tonami Hisao:The role of changes in maximum standardized uptake value of FDG PET-CT for post-treatment surveillance in patients with head and neck squamous cell carcinoma treated with chemoradiotherapy: preliminary findings, BRITISH JOURNAL
OF RADIOLOGY, 90:20150404, 2017.
Reviews 0400C001 Katsuo Usuda, Takuma Matsui, Nozomu Motono, Yuichiro Machida, Munetaka Matoba, Hisao Tonami, Yoshimichi Ueda, Hidetaka Uramoto:Diagnostic benefits and prospects of diffusion-weighted magnetic resonance imaging (DWI) for thoracic tumor, The Journal of the Japanese Association for Chest Surgery, 6:5;305-311, 2017.
Presentations at Conference
International Conference (Presentations) 0400I001 Hideaki Shiga, Junichi Taki, Koichi Okuda, Naoto Watanabe, Hisao Tonami, Seigo Kinuya, Takaki Miwa: Correlation of thallium olfactory transport and olfactory bulb volume in patients with olfactory impairment after upper respiratory infection, AChemS 39th Annual Meeting 2017, Florida, 2017.04.
0400I002 Katsuo Usuda, Nozomu Motono, Makoto Tanaka, Yuichiro Machida, Takuma Matsui, Munetaka Matoba, Hidetaka Uramoto:Diagnostic performance of diffusion weighted imaging for multiple hilar and mediastinal lymph nodes FDG
accumulation, BIT's 10th Annual World CANCER Congress-2017, Barcelona, 2017.05.
0400I003 H.Nagata, M.Matoba, M.Doai, T.Takahashi, Y.Ishida, M.Kawashima, H.Tonami:New Method for Diagnosing Metastatic Cervical Lymph Nodes With Head And Neck Squamous Cell Carcinoma Using Third-Generation Dual- Energy CT, The 103nd Scientific Assembly & Annual Meeting of the Radiological Society of North America Annual
Meeting, Chicago, 2017.11.
0400I004 M.Doai, N.Tsuchiya, H.Tonami, K.Usuda, H.Uramoto, M.Matoba:Whole-lesion evaluation of lung adenocarcinoma for predicting pathological grade:Comparative study between histogram Parameters of ADC on DWI,and MTV as well as TLG on 18F-FDG PET/CT, The 103nd Scientific Assembly & Annual Meeting of the Radiological Society
of North America Annual Meeting, Chicago, 2017.11.
- 55 - 0412 Department of Cardiovascular Surgery
Faculty
Title Name Field of Specialization Professor SAKAMOTO Shigeru Cardiovascular Surgery Professor SHIKATA Hiroo Vascular Surgery Associate Professor NAGAYOSHI Yasuhiro Cardiovascular Surgery Associate Professor ISHIMARU Kazuhiko Pedeatric Cardiovascular Surgery Senior Assistant Professor NOGUCHI Yasuhisa Vascular Surgery Assistant Professor ARAKI Kanta Pediatric Cardiovascular Surgery Assistant Professor SAKAMOTO Daisuke Cardiovascular Surgery Assistant Professor TANAKA Hirokazu Cardiovascular Surgery Assistant Professor TSUCHIYA Hirokazu Vascular Surgery
Keywords of Research
cardiovascular Surgery, Ischemic Heart Surgery, Valuvlar heart Surgery, ASO, TAO, TEVAR, EVAR, Left and Right ventricular assist system (L & R VAS), Cardiac surgery for severe heart failure, Raser surgery, CABG, OPCAB, Dor'S operation, IABP , PCPS, Batista's operation, Pacemaker implantation, Adult cardiac surgery, Pediatric cardiac srugery
- 56 - 0415 Department of Thoracic Surgery
Faculty
Title Name Field of Specialization Professor URAMOTO Hidetaka Thoracic Surgery,Video assisted thoracoscopic surgery,Lung Cancer thoracic surgery, video assisted thoracoscopic surgery, lung cancer, Professor USUDA Katsuo mediastinal tumor, early lung cancer, interventional bronchology, clinical cytology Assistant Professor MACHIDA Yuichiro thoracic surgery, lung cancer, pulmonary circulation Assistant Professor MOTONO Nozomu thoracic surgery, lung cancer, pulmonary circulation Assistant Professor MATSUI Takuma thoracic surgery, lung cancer Assistant Professor SEKIMURA Atsushi thoracic surgery, lung cancer Assistant Professor MAEDA Ryo thoracic surgery, lung cancer Assistant Professor FUNASAKI Aika thoracic surgery, lung cancer
Keywords of Research
thoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy, lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax
Outline of Research
Lung tumor 1. Screening test for lung cancer 2. Virtual bronchoscopy 3. Ion channel on cancer cells 4. Chemotherapy 5. Surgical treatment 6. Video assisted thoracoscopic surgery (VATS)
Mediastinal and pleural tumors 1. FDG-PET for mediastinal tumor 2. VATS 3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury 1. Perioperative lung injury 2. Beta-agonist and antagonist therapy 3. Ischemia reperfusion lung injury 4. Aspiration lung injury 5. RAGE mice
New instruments 1. Bronchoscopy 2. Thoracoscopy
- 57 - Publications
Originals 0415B001 Tsuchiya Naoko, Doai Mariko, Usuda Katsuo, Uramoto Hidetaka, Tonami Hisao:Non-small cell lung cancer: Whole-lesion histogram analysis of the apparent diffusion coefficient for assessment of tumor grade, lymphovascular
invasion and pleural invasion., PloS one, 12:2;e0172433, 2017.
0415B002 Usuda Katsuo, Funazaki Aika;, Maeda Ryo, Sekimura Atsushi, Motono Nozomu, Matoba Munetaka, Uramoto Hidetaka:Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging for
Primary Lung Cancer, Annals of Thoracic and Cardiovascular Surgery, 23:6;275-280, 2017.
0415B003 (Hajime Kikuchi), Jun Sakakibara-Konishi, Megumi Furuta, Hiroshi Yokouchi, Hiroshi Nishihara, Shigeo Yamazaki, Shigeo Yamazaki, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita, Kei Takamura, Tetsuya Kojima, Toshiyuki Harada, Mitsunori Higuchi, Osamu Honjo, Yoshinori Minami, Naomi Watanabe, Satoshi Oizumi, Hiroyuki Suzuki, Takashi Ishida, Hirotoshi Dosaka-Akita, Hiroshi Isobe, Mitsuru Munakata, Masaharu Nishimura:Expression of notch1 and numb in small cell lung cancer, Oncotarget, 2:1-11,
2017.
0415B004 Yuki Nakajima, Yoshihito Iijima, Hiroyasu Kinoshita, Hirohiko Akiyama, Takeshi Beppu, Hidetaka Uramoto, Tomomi Hirata:Surgical Treatment for Pulmonary Metastasis of Head and Neck Cancer: Study of 58 Cases., Annals
of thoracic and cardiovascular surgery, 23:4;169-174, 2017.
0415B005 (Gemmill Robert M), Nasarre Patrick, Nair-Menon Joyce, Cappuzzo Federico, Landi Lorenza, D'Incecco Armida, Uramoto Hidetaka, Yoshida Takeshi, Haura Eric B, Armeson Kent, Drabkin Harry A:The neuropilin 2 isoform
NRP2b uniquely supports TGF beta-mediated progression in lung cancer, Science signaling, 10:462;1-11, 2017.
0415B006 Motono Nozomu, Matsui Takuma, Machida Yuichiro, Usuda Katsuo, Uramoto Hidetaka:Prognostic significance of
histologic subtype in pStage I lung adenocarcinoma., Medical oncology, 34:6;2-6, 2017.
0415B007 Yamamoto Gou, Kikuchi Mari, Kobayashi Shiho, Arai Yoshiko, Fujiyoshi Kenji, Wakatsuki Tomokazu, Kakuta Miho, Yamane Yuki, Iijima Yoshihito, Mizutani Hideaki, Nakajima Yuki, Sudo Junko, Kinoshita Hiroyasu, Kurimoto Futoshi, Akiyama Hirohiko, Uramoto Hidetaka, Sakai Hiroshi, Akagi Yoshito, Akagi Kiwamu:Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation
sequencing, INTERNATIONAL JOURNAL OF ONCOLOGY, 50:5;1579-1589, 2017.
0415B008 Usuda Katsuo, Maeda Sumiko, Motomo Nozomu, Tanaka Makoto, Ueno Masakatsu, Machida Yuichiro, Sagawa Motoyasu, Uramoto Hidetaka:Pulmonary Function After Lobectomy: Video-Assisted Thoracoscopic Surgery
Versus Muscle-Sparing Mini-thoracotomy, INDIAN JOURNAL OF SURGERY, 79:6;504-509, 2017.
0415B009 Matsumura Yuki, Suzuki Hiroyuki, Ohira Tetsuya, Shiono Satoshi, Abe Jiro, Sagawa Motoyasu, Sakurada Akira, Katahira Masato, Machida Yuichiro, Takahashi Satomi, Okada Yoshinori:Matched-pair analysis of a multi- institutional cohort reveals that epidermal growth factor receptor mutation is not a risk factor for postoperative
recurrence of lung adenocarcinoma., Lung cancer, 114:23-30, 2017.
Reviews 0415C001 Katsuo Usuda, Takuma Matsui, Nozomu Motono, Yuichiro Machida, Munetaka Matoba, Hisao Tonami, Yoshimichi Ueda, Hidetaka Uramoto:Diagnostic benefits and prospects of diffusion-weighted magnetic resonance imaging
(DWI) for thoracic tumor, The Journal of the Japanese Association for Chest Surgery, 6:5;305-311, 2017.
Case Reports 0415D001 Machida Yuichiro, Motono Nozomu, Matsui Takuma, Usuda Katsuo, Uramoto Hidetaka:Successful endovascular coil embolization in an elder and asymptomatic case of anomalous systemic arterial supply to the normal basal
segment, International journal of surgery case reports, 34:103-105, 2017.
0415D002 (Iijima Yoshihito), Kinoshita Hiroyasu, Nakajima Yuki, Akiyama Hirohiko, Uramoto Hidetaka, Hirata Tomomi, Isolated solitary lung metastasis 12 years after radical prostatectomy for prostate cancer without elevation of the serum prostate-specific antigen level, The Journal of the Japanese Association for Chest Surgery, 31:5;648-652,
2017.
- 58 - 0415D003 Atsushi Sekimura, Takashi Yoshimatsu, Naoki Yamashita, Hanae Higa, Takeaki Miyata, Daigo Kawano, Tetsuya So, Hidetaka Uramoto:Prediction of Pleural Adherence Area Used by Ultrasound Sonography, The Japanese Journal of
Thoracic Surgery, 70:10;819-821, 2017.
0415D004 Matsui Takuma, Motono Nozomu, Machida Yuichiro, Usuda Katsuo, Uramoto Hidetaka:A case of primary myoepithelial carcinoma of lung that was difficult to diagnose preoperatively, The Journal of the Japanese
Association for Chest Surgery, 31:5;633-637, 2017.
0415D005 Nozomu Motono, Aika Funasaki, Astushi Sekimura, Katsuo Usuda, Masahito Kawaguchi, Norio Kawahara, Hidetaka Uramoto:Dividing the procedures into lobectomy and vertebrectomy for large lung cancer invading the spine, Journal of Cancer Science and Research, 3:S1, 2017.
Presentations at Conference
International Conference (Presentations) 0415I001 Katsuo Usuda, Nozomu Motono, Makoto Tanaka, Yuichiro Machida, Takuma Matsui, Munetaka Matoba, Hidetaka Uramoto:Diagnostic performance of diffusion weighted imaging for multiple hilar and mediastinal lymph nodes FDG
accumulation, BIT's 10th Annual World CANCER Congress-2017, Barcelona, 2017.
0415I002 Nozomu Motono:Sphingosine kinase1(SPHK1)promoters proliferation and surnival in non-small cell lung cancer,
IASLC 18TH World conference on lung cancer, Yokohama, 2017.
0415I003 M.Doai, N.Tsuchiya, H.Tonami, K.Usuda, H.Uramoto, M.Matoba:Whole-lesion evaluation of lung adenocarcinoma for predicting pathological grade:Comparative study between histogram Parameters of ADC on DWI,and MTV as well as TLG on 18F-FDG PET/CT., The 103nd Scientific Assembly & Annual Meeting of the Radiological Society
of North America Annual Meeting, Chicago, 2017.11.
- 59 - 0420 Department of General and Digestive Surgery
Faculty
Title Name Field of Specialization Professor KOSAKA Takeo Surgical treatment of gastric cancer Professor UEDA Nobuhiko Surgical treatment of hepatobiliary and pancreatic disease Professor NOGUCHI Masakuni Surgery of breast cancer Associate Professor KINAMI Shinichi Surgical treatment of gastric cancer Associate Professor NAKANO Yasuharu Surgery of breast cancer Senior Assistant Professor FUJITA Hideto Surgical treatment of gastric cancer, Senior Assistant Professor NOGUCHI Miki Surgery of breast cancer Assistant Professor ONISHI Toshio Surgery of Digestive Diseases Assistant Professor ONO Yukako Surgery of Digestive Diseases, Surgical treatment of breast cancer Assistant Professor KAIDA Daisuke Surgery of Digestive Diseases Assistant Professor TOMITA Yasuto Surgery of Digestive Diseases Assistant Professor MORIOKA Emi Surgery of Digestive Diseases Assistant Professor FUJITA Jun Surgery of Digestive Diseases Assistant Professor MIURA Seiko Assistant Professor FUJII Yoritaka
Keywords of Research
pancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of the laparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization, functional preserving operation, education and training, engineering and robotics,
Outline of Research
1 Advanced surgery for gastrointrestinal cancer 2 Biomarker of gastrointestinal cancer 3 Gastrointestinal reconstruction and its evaluation 4 Function saving cancer surgery 5 Minimally invasive cancer treatment 6 Tailored cancer chemotherapy
Publications
Originals 0420B001 Y.Nakano, M.Noguchi, M.Yokoi-Noguchi, Y.Ohno, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of 18F-FDG-PET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients.,
Breast cancer, 24:1;121-127, 2017.
- 60 - 0420B002 (Masazumi Takahashi), Masanori Terashima, Hiroshi Kawahira, Eishi Nagai, Yoshikazu Uenosono, Shinichi Kinami, Yasuhiro Nagata, Masashi Yoshida, Keishiro Aoyagi, Yasuhiro Kodera, Koji Nakada:Quality of life after total vs disital gastrectomy with Roux-en-Y reconstruction: Use of the postgatrectomy syndrome assessment scale-45,
World Journal of Gastroenterology, 23:11;2068-2076, 2017.
0420B003 (Asako Sasahara), Kana Tominaga, Tatsunori Nishimura, Masao Yano, Etsuko Kiyokawa, Miki Noguchi, Masakuni Noguchi, Hajime Kanauchi, Toshihisa Ogawa, Hiroshi Minato, Keiichiro Tada, Yasuyuki Seto, Arinobu Tojo, Noriko Gotoh:An autocrine / paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of
breast cancer stem-like cells, Oncotarget, 8:15;24869-24881, 2017.
0420B004 Toshio Ohnishi, Shinici Kinami, Yoritaka Fujii, Seiko Miura, Jun Fujita, Daisuke Kaida, Yasuto Tomita, Hideto Fujita, Yasuharu Nakano, Nobuhiko Ueda, Takeo Kosaka:Prognosis of conversion gatrectomy cases for stage Ⅳ
gastric cancer, Japanese Journal of Cancer and Chemotherapy, 44:12;1799-1801, 2017.
0420B005 Toshio Ohnishi, Chieko Hashizume, Makoto Taniguchi, Hidehiro Furumoto, Jia Han, Rongfen Gao, Shinichi Kinami, Takeo Kosaka, Toshiro Okazaki:Sphingomyelin synthase 2 deficiency inhibits the induction of murine
colitis-associated colon cancer, The Faseb Journal, 31:9;3816-3830, 2017.
0420B006 Shinich Kinami, Toshio Ohnishi, Yoritaka Fujii, Seiko Miura, Jun Fujita, Yasuto Tomita, Hideto Fujita, Nobuhiko Ueda, Yasuharu Nakano, Takeo Kosaka:ICG fluorescence sentinel node biopsy for early gastric cancer, Japanese Journal of Lymphology, 40:2;107-112, 2017.
Reviews 0420C001 Shinichi Kinami, Takeo Kosaka:Laparoscopic sentinel node navigation surgery for early gastric cancer,
Translational Gastroenterology and Hepatology, 2:42, 2017.
Case Reports 0420D001 Toshio Onishi, Shinichi Kinami, Yasuto Tomita, Hideto Fujita, Nobuhiko Ueda, Takeo Kosaka:Desmoid-type fibromatosis after laparoscopic endoscopic co-operative surgery for a gastrointestinal stromal tumor of stomach -
A case report -, Journal of Japan Surgical Association, 78:5;988-993, 2017.
0420D002 Seiko Miura, Nobuhiko Ueda, Hideto Fujita, Shinichi Kinami, Yasuharu Nakano, Takeo Kosaka, Noriaki Sakata, Ryouhei Nishino:A case unresectable gastric cancer with multiple metastases responding to chemotherapy,
Japanese Journal of Cancer and Chemotherapy, 44:12;1781-1783, 2017.
0420D003 Nobuhiko Ueda, Yoritaka Fujii, Seiko Miura, Jun Fujita, Yasuto Tomita, Toshio Ohnishi, Hideto Fujita, Shinichi Kinami, Kazuhiko Omote, Yasuharu Nakano, Takeo Kosaka, Yoshiharu Motoo:Long-term survival due to combination therapy in a patient with locally advanced body-tall pancreatic cancer, Japanese Journal of Cancer and
Chemotherapy, 44:12;1373-1375, 2017.
Presentations at Conference
International Conference (Key Note Lecture) 0420G001 Toshiro Okazaki, Chieko Hashizume, Makoto Taniguchi, Takeo Kosaka:Role of sphingomyeline synthase 2 (SMS2) in murine colitis and colon cancer, 3rd International Conference on New Horizons of Basic nd Applied Science,
Hurghada, 2017.08.
International Conference (Presentations) 0420I001 Seiko Miura, Nobuhiko Ueda, Toshio Onishi, Yasuto Tomita, Hideto Fujita, Shinichi Kinami, Yasuharu Nakano, Takeo Kosaka, Akane Aikawa, Hiroshi Minato, Takayuki Nojima:Multilocular cystic intrahepatic cholangiocarcinoma : A case report, Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato- Pancreato-Billiary Associaion. The 29th Meeting of Japanese Society of Hepato-Billiary-Pancreatic Surgery, Yokohama, 2017.06.
0420I002 Nobuhiko Ueda, Seiko Miura, Yasuto Tomita, Toshio Onishi, Hideto Fujita, Shinichi Kinami, Yasuharu Nakano, Takeo Kosaka, Akane Aikawa, Hiroshi Minato, Takayuki Nojima:Surgical management of intraducyal papillary mucinous neoplasms, Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Billiary
Associaion. The 29th Meeting of Japanese Society of Hepato-Billiary-Pancreatic Surgery, Yokohama, 2017.06.
- 61 - 0430 Department of Orthopaedic Surgery
Faculty
Title Name Field of Specialization Professor KAWAHARA Norio Spinal surgery Professor KANEUJI Ayumi Hip and Knee surgery, Sports medicine Professor MATSUMOTO Tadami Hip surgery Associate Professor ICHISEKI Toru Hip surgery, Shoulder surgery Senior Assistant Professor FUKUI Kiyokazu Hip surgery Senior Assistant Professor HIROMURA Kentaro Trauma KAWAGUCHI Senior Assistant Professor Spinal surgery Masahito Assistant Professor ORITA Yugo Spinal surgery, orthopaedic surgery Assistant Professor TAKAHASHI Eiji Hip surgery Assistant Professor TACHI Yoshiyuki Spinal surgery Assistant Professor SHIMIZU Yoshiaki Spinal surgery Assistant Professor UEDA Shusuke Hip surgery Assistant Professor TSUDA Ryoji Hip surgery Assistant Professor SOMA Daisuke orthopadeic Surgery YONEZAWA Assistant Professor Spinal surgery, orthopaedic surgery Katsutaka Assistant Professor KANEKO Seiji Hip surgery
Keywords of Research
herniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor, coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft, patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbar interbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture, humeral shaft fracture, osteonecrosis, implant coating.
Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we are researching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced osteonecrosis of femoral head to prevent the occurrence of the disease. Furthermore, we perform a study to make antibacterial implant to prevent SSI. We confirmed that fluoride added DLC coating does not have cytotoxicity, and its bactericidal effect for staphylococcus aureus and E.coli. We are going to continue this study for manufacture.
- 62 - Publications
Originals 0430B001 Toru Ichiseki, Shusuke Ueda, Yoshimichi Ueda, Masanobu Tuchiya, Ayumi Kaneuji, Norio Kawahara:Involvement of necroptosis, a newly recognized cell death type, in steroid-induced osteonecrosis in a rabbit model, International
journal of medical sciences, 14:110-114, 2017.
0430B002 (Kensei Yoshimoto), Yasuharu Nakashima, Shigeo Aota, Ayumi Kaneuji, Kiyokazu Fukui, Kazuo Hirakawa, Nariaki Nakura, Koichi Kinoshita, Masatoshi Naito, Yukihide Iwamoto:Re-dislocation after revision total hip arthroplasty
for recurrent dislocation: a multicentre study, International orthopaedics, 41:253-258, 2017.
0430B003 Eiji Takahashi, Ayumi Kaneuji, Ryoji Tsuda, Yuhei Numata, Toru Ichiseki, Kiyokazu Fukui, Norio Kawahara:The influence of cement thickness on stem subsidence and cement creep in a collarless polished tapered stem: When
are thick cement mantles detrimental?, Bone & joint research, 6:351-357, 2017.
0430B004 (A.Amelot), L.Balabaud, D.Choi, Z.Fox, HA.Crockard, T.Albert, CM.Arts, JM.Buchowski, C.Bunger, CK.Chung, MH.Coppes, B.Depreitere, MG.Fehlings, J.Harrop, N.Kawahara, ES.Kim, CS.Lee, Y.Leung, ZJ.Liu, JA.Martin- Benlloch, EM.Massicotte, B.Meyer, FC.Oner, W.Peul, N.Quraishi, Y.Tokuhashi, K.Tomita, C.Ulbricht, JJ.Verlaan, M.Wang, C.Mazel:Surgery for metastatic spine tumors in the elderly. Advanced age is not a contraindication to
surgery!, The spine journal, 17:759-767, 2017.
0430B005 (Kyoko Kondo), Seiya Jingushi, Satoko Ohfuji, Muroto Sofue, Moritoshi Itoman, Tadami Matsumoto, Yoshiki Hamada, Hiroyuki Shindo, Yoshio Takatori, Harumoto Yamada, Yuji Yasunaga, Hiroshi Ito, Satoshi Mori, Ichiro Owan, Genji Fujii, Hirotsugu Ohashi, Wakaba Fukushima, Akiko Maeda, Miki Inui, Shinji Takahashi, Yoshio Hirota :Factors associated with functional limitations in the daily living activities of Japanese hip osteoarthritis patients, International journal of rheumatic diseases, 20:1372-1382, 2017.
0430B006 (Kazuhiro Shintani), Takuya Kobayashi, Masahito Kawaguchi, Norio Kawahara, Ayumi Kaneuji:Causes of high osteoconductivity of 3D honeycomb artificial footing material with DLC coating, Japanese Journal of Clinical
Biomechanics, 38:213-218, 2017.
0430B007 (Hideaki Kawakami), Katsutaka Yonezawa, Kazuhiro Shintani, Norio Kakawaha:Study on application of si3n4-hbn
ceramics to the vertebral body, Japanese Journal of Clinical Biomechanics, 38:207-211, 2017.
0430B008 Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Yoshimichi Ueda, Masanobu Tsuchiya, Ayumi Kaneuji, Norio Kawahara:Prevention of glucocorticoid-associated osteonecrosis by intravenous administration of mesenchymal
stem cells in a rabbit model, BMC musculoskeletal disorders, 18:480, 2017.
0430B009 (Yuma Sakamoto), Takuaki Yamamoto, Nobuhiko Sugano, Daisuke Takahashi, Toshiyuki Watanabe, Takashi Atsumi, Junichi Nakamura, Yukiharu Hasegawa, Koichi Akashi, Ichiei Narita, Takeshi Miyamoto, Tsutomu Takeuchi, Katsunori Ikari, Koichi Amano, Atsuhiro Fujie, Toshikazu Kubo, Yoshifumi Tada, Ayumi Kaneuji, Hiroaki Nakamura, Tomoya Miyamura, Tamon Kabata, Ken Yamaji, Takahiro Okawa, Akihiro Sudo, Kenji Ohzono, Yoshiya Tanaka, Yuji Yasunaga, Shuichi Matsuda, Yuuki Imai, Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head, Masato Akiyama, Michiaki Kubo, Yoichiro Kamatani, Yukihide Iwamoto, Shiro Ikegawa:Genome-wide association study of idiopathic osteonecrosis of the femoral head, Scientific reports,
7:15035, 2017.
Case Reports 0430D001 Toru Ichiseki, Shusuke Ueda, Ayumi Kaneuji, Norio Kawahara:Massive tear of an ossified supraspinatus tendon: a case report and review of the literature, International journal of clinical and experimental medicine, 10:1429-1433,
2017.
0430D002 Norio Kawahara, Hidetaka Uramoto:Dividing the procedures into lobectomy and vertebrectomy for large lung
cancer invading the spine, Journal of Lung Cancer Diagnosis & Treatment, 2:4;118, 2017.
0430D003 Nozomu Motono, Aika Funasaki, Astushi Sekimura, Katsuo Usuda, Masahito Kawaguchi, Norio Kawahara, Hidetaka Uramoto:Dividing the procedures into lobectomy and vertebrectomy for large lung cancer invading the spine, Journal of Cancer Science and Research, 3:S1, 2017.
- 63 -
Presentations at Conference
International Conference (Key Note Lecture) 0430G001 Norio Kawahara:Surgery for spinal metastasis from RCC, 16th Korean Spine Oncology Research Society, Seoul,
2017.08.
0430G002 Norio Kawahara:Total en-bloc spondylectomy of the lumbar spine, 16th Korean Spine Oncology Research Society,
Seoul, 2017.08.
0430G003 Norio Kawahara:TES in special focus into the lumbar spine, AOSpine Principles Course in Management of
Vertebral Tumors, Manila, 2017.11.
0430G004 Norio Kawahara:Reconstruction/fixation and fusion techniques after en bloc resection, AOSpine Principles Course
in Management of Vertebral Tumors, Manila, 2017.11.
0430G005 Norio Kawahara:Soft tissue and wound reconstruction techniques in spinal tumor surgery, AOSpine Principles
Course in Management of Vertebral Tumors, Manila, 2017.11.
International Conference (Symposium) 0430H001 Ayumi Kaneuji, Kiyokazu Fukui, Toru Ichiseki, Norio Kawahara:Total hip arthroplasty after rotational acetabular
osteotomy, 2017 ICJR Japan (International Congress for Joint Reconstruction), Tokyo, 2017.04.
International Conference (Presentations) 0430I001 (CR.Bragdon), CJ.Barr, CS.Nielsen, D.Berry, CJ.Della Valle, K.Garvin, PE.Johansson, J.Clohisy, A.Kaneuji, H.Malchau:Minimum 10-13 year multi-center study of THA with highly cross-linked polyethylene and ceramic or
cobalt chrome femoral heads, The 2017 AAHKS Annual Meeting, Dallas, 2017.11.
- 64 - 0440 Department of Neurosurgery
Faculty
Title Name Field of Specialization Professor IIZUKA Hideaki spinal disease, brain tumor, peripheral nerve disease Professor TACHIBANA Osamu brain tumor, hypothalamic and pituitary tumor Professor TAKADA Hisashi cerebrovascular disease，endovascular therapy Senior Assistant Professor OKAMOTO Kazuya brain tumor, stereotactic radiosurgery Senior Assistant Professor SIRAGA Syunsuke cerebrovascular disease Assistant Professor TAMASE Akira spinal disease Assistant Professor TSUKADA Tsuyoshi General Neurosurgery (Additional Post)
Keywords of Research
brain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm, arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery, spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia, spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral ischemia
Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, the researchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies. 1. Brain tumor 1) development of tumor differentiation induction therapy for malignant gliomas 2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study) 3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classification and protein expression study) 4) radiological diagnosis of cystic pituitary tumors 5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease 1) disclose the cord degeneration mechanism by spinal cord compression model 2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease 1) disclose the molecular biological mechanism for acquisition of cerebral ischemia
4. Head injury 1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly 1) treatment of hydrocephalus in fetus model 2) disclose the responsible gene and surgical treatment for craniosynostosis
- 65 - Publications
Originals 0440B001 (Y.Sasagawa), Y.Hayashi, O.Tachibana, M.Oishi, I.Fukui, H.Iizuka, M.Nakada:Clinical characteristics of acromegalic patients with empty sella and their outcomes following transsphenoidal surgery, Pituitary, 20:4;403-
408, 2017.
0440B002 (I.Fukui), Y.Hayashi, D.Kita, Y.Sasagawa, M.Oishi, O.Tachibana, M.Nakada:Significant Improvement in Chronic Persistent Headaches Caused by Small Rathke Cleft Cysts After Transsphenoidal Surgery, World Neurosurgery,
99:362-368, 2017.
0440B003 (Y.Hayashi), Y.Sasagawa, D.Kita, I.Fukui, M.Oishi, O.Tachibana, F.Ueda, M.Nakada:Contribution of sellar dura integrity to symptom manifestation in pituitary adenomas with intratumoral hemorrhage, Pituitary, 20:5;531-538,
2017.
0440B004 (Y.Hayashi), D.Kita, I.Fukui, Y.Sasagawa, M.Oishi, O.Tachibana, F.Ueda, M.Nakada:Preoperative Evaluation of the Interface Between Tuberculum Sellae Meningioma and the Optic Nerves on Fast Imaging with Steady-State Acquisition for Extended Endoscopic Endonasal Transsphenoidal Surgery, World Neurosurgery, 103:153-160,
2017.
Presentations at Conference
International Conference (Presentations) 0440I001 O.Tachibana, Y.Hayashi, Y.Sasagawa, S.Takada ,A.Tamase, S.Shiraga, K.Okamoto, A.Nakagawa, D.Koya, M.Nakada,H. Iiduka:The efficacy of intra-operative topical dexamethasone administration on the prevention of Rathke cleft cyst re-accumulation and recurrence, The 1st meeting of Japan-China Neurosurgery Alliance, The 9th Neurosurgery Conference of China and Japan, Zhengzhou Dengfeng, 2017.
- 66 - 0450 Department of Plastic and Reconstructive Surgery
Faculty
Title Name Field of Specialization Professor SHIMADA Kenichi Plastic and Reconstructive Surgery Professor KAWAKAMI Shigehiko Plastic and Reconstructive Surgery Associate Professor KISHIBE Miyuki Plastic and Reconstructive Surgery YAMASHITA Senior Assistant Professor Plastic and Reconstructive Surgery Masanobu Senior Assistant Professor YAMASHITA Akiko Plastic and Reconstructive Surgery Senior Assistant Professor MIYANAGA Toru Plastic and Reconstructive Surgery Assistant Professor YAMAMOTO Yasunori Plastic and Reconstructive Surgery Assistant Professor KADOHIRA Mitsuhiro Plastic and Reconstructive Surgery Assistant Professor KANEKO Takayoshi Plastic and Reconstructive Surgery Assistant Professor SUGISHITA Kazuyuki Plastic and Reconstructive Surgery Assistant Professor DAIZO Haruhisa Plastic and Reconstructive Surgery Assistant Professor NISHIBU Yasuhiro Plastic and Reconstructive Surgery Assistant Professor HIMI Yuji Plastic and Reconstructive Surgery Assistant Professor YAGISHITA Mikio Plastic and Reconstructive Surgery Assistant Professor SAKAGAMI Akihiko Plastic and Reconstructive Surgery Assistant Professor YONEZAWA Minami Assistant Professor KAWAMURA Ryo Assistant Professor TAKEMURA Tomoko Assistant Professor MAKIMOTO Kazuhiko Assistant Professor MORIMOTO Yayoi Assistant Professor IGAWA Yuichi
Keywords of Research
fibroblast, FGF receptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocyte, wound healing, craniofacial surgery, zygoma, cleft lip, cleft palate, microtia, tissue expansion, crainofacial cleft, front-orbital advancement, microsurgery, free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in congenital anomaly
Outline of Research
1) Wound healing Promoting effects of wound dressings or drugs in wound healing process are studied clinicaly. 2) Tissue engineering Regeneration of the skin and subcutaneous tissue using artificial materials are studied clinicaly and experimentally 3) Cranio-maxillo-facial surgery New operative procedures in cranio-maxillo-facial fields are attempted to develope.
- 67 - Publications
Originals 0450B001 Mikio Yagishita, Haruhisa Daizo, Toru Miyanaga, Kenichi Shimada:Donor Site Morbidity in Cross Finger Flaps, J
Jpn Soc Surg Hand, 34:3;400-404, 2017.
0450B002 Toru Miyanaga, Kenichi Shimada, Miyuki Kishibe, Masanobu Yamashita, Akiko Yamashita:The Double Volar Flap Technique for Aesthetic Repair of Syndactyly and Polysyndactyly of Toe without Skin Grafting, PLASTIC AND
RECONSTRUCTIVE SURGERY, 5:4;e1293, 2017.
- 68 - 0460 Department of Pediatric Surgery
Faculty
Title Name Field of Specialization Professor KOHNO Miyuki Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy Senior Assistant Professor YOSHIZAKI Hisayoshi Pediatric surgery Senior Assistant Professor YASUI Yoshitomo Pediatric surgery Assistant Professor KUWAHARA Tsuyoshi Pediatric surgery Assistant Professor SATOMI Miwa Pediatric surgery SHIRONOMAE Assistant Professor Pediatric surgery Tsubasa
Keywords of Research
inguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriary atresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastro- esophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor, pediatric urology, phimosis, intestinal stoma,
Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia. The importance of rectal branch to induce high amplitude propagated colonic contraction. Clinical study of pediatric endoscopic surgery. Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.
Publications
Originals 0460B001 (M.Sato), Y.Hamada, M.Kohno, K.Ise, K.Uchida, H.Ogata, H.Masuyama, Y.Morotomi, M. Yasufuku, M.Wada:
Neonatal gastrointestinal perforation in Japan: a nationwide survey., Pediatr Surg Int, 33:33-41, 2017.
0460B002 Tsubasa Shironomae, Miyuki Kohno, Shoichi Nishida, Miwa Satomi, Tsuyoshi Kuwahara, Yoshitomo Yasui: Endoscopic Marsupialization of a Laryngeal Cyst in a Neonate: A Case Report, Journal of the Japanese Society of
Pediatric Surgeons, 53:911-915, 2017.
0460B003 Y.Yasui, S.Nishida, T.Shironomae, M.Satomi, T.Kuwahara, M.Kohno:Surgical approach for fecal incontinence with a patulous anus after transanal pull-through for Hirschsprung disease, Journal of pediatric surgery, 52:6;1070-
1075, 2017.
0460B004 Jinpeng Li, Sen Shi, Swayam Prakash Srivastava, Munehiro Kitada, Takako Nagai, Kyoko Nitta, Miyuki Kohno, Keizo Kanasaki, Daisuke Koya:FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N- acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway, CELL DEATH & DISEASE, 8:e2965,
2017.
0460B005 Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation of
multiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.
- 69 - Case Reports 0460D001 Tsubasa Shironomae, Miyuki Kohno, Shoichi Nishida, Miwa Satomi, Tsuyoshi Kuwahara, Yoshitomo Yasui:TWO
PEDIATRIC CASES OF ECTOPIC ADRENAL TISSUE IN THE SPERMATIC CORD, 26:1;73-75, 2017.
0460D002 Tsubasa Shironomae, Miyuki Kohno, Shoichi Nishida, Miwa Satomi, Tsuyoshi Kuwahara, Yoshitomo Yasui:
Endoscopic Marsupialization of a Laryngeal Cyst in a Neonate: A Case Report, 53:911-915, 2017.
0460D003 Y.Yasui, M.Kohno, S.Nishida, T.Shironomae, M.Satomi, T.Kuwahara, S.Takahashi, Y.Niida:Cartilage-hair hypoplasia associated with isolated hypoganglionosis: A case report, CONGENITAL ANOMALIES, 57:1;32-34,
2017.
- 70 - 0470 Department of Ophthalmology
Faculty
Title Name Field of Specialization cataract, epidemiology, uveitis, electromagnetic ocular injury, Professor SASAKI Hiroshi ultraviolet Professor KUBO Eri cataract, oxidative stress and eye disease, diabetic eye complication cataract, ophthalmological optics, electromagnetic ocular injury, Professor(Additional Post) KOJIMA Masami epidemiology Associate Professor FUKUDA Masamichi ocular pharmacology, intraocular, penetration Senior Assistant Professor KAWAKAMI Yutaka cataract Senior Assistant Professor SHIBATA Shinsuke cataract, ophthalmology, oxidative stress and eye disease Senior Assistant Professor SHIBATA Naoko cataract, ophthalmology, oxidative stress and eye disease Assistant Professor ARIMOTO Atsushi macular degeneration Assistant Professor OSADA Hiromi cataract, ophthalmology, macular degeneration Assistant Professor HATSUSAKA Natsuko ophthalmological optics, epidemiology, ultraviolet Assistant Professor FUJITA Nobuyuki uveitis Assistant Professor SHIBATA Teppei cataract, oxidative stress and eye disease Assistant Professor MIYASHITA Hisanori cataract, epidemiology
Keywords of Research
proteomics, cataract classification, corneal epithelium, crystalline lens, dry eye, glaucoma, image analysis, lens sectioning technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UV- dosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herpetic keratitis, intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional image, V-E, intraocular lens(IOL), cell culture
Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places (Ishikawa and Kagoshima, Japan, Singapore, Iceland, China and Tanzania). These studies have included prevalence, incidence and risk factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked on image analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visual performance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animal models and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases is also underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method for measuring corneal damage in vivo are all being investigated.
- 71 - Publications
Originals 0470B001 (Noriaki Nagai), Yu Mano, Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:Amyloid β1-43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients, Investigative Ophthalmology & Visual Science,
58:3294-3302, 2017.
0470B002 Hiroshi Sasaki:Primary and secondary preventions of cataracts, Rinsho Ganka, 71:1;52-60, 2017.
0470B003 (Noriaki Nagai), Yoshimasa Ito, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:A positive feedback loop between nitric oxide and amyloid β(1-42) accelerates mitochondrial damage in human lens epithelial cells, Toxicology, 381:19-
30, 2017.
0470B004 E.Kubo, S.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, Dhirendra P.Singh:FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity., Journal of Cellular and Molecular Medicine,
21:5;916-928, 2017.
0470B005 (Koji Kitazawa), Chie Sotozono, Noriko Koizumi, Kenji Nagata, Tsutomu Inatomi, Hiroshi Sasaki, Shigeru Kinoshita:Safety of anterior chamber paracentesis using a 30-gauge needle integrated with a specially designed
disposable pipette, British Journal Of Ophthalmology, 101:548-550, 2017.
0470B006 (Norihiro Mita), Hiroshi Sasaki, Kazutaka Kani, Akio Tabuchi, Heihachiro Hara:Multiple comparisons in two-factor testing of psychophysical thresholds by the delta test method, Communications in statistics-simulation and
computation, 46:1;669-678, 2017.
0470B007 (Bhavana Chhunchha), Eri Kubo, Nigar Fatma, Dhirendra P Singh:Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation,
Cell Death and Disease, 8:e2525;1, 2017.
0470B008 Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P. Singh:Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, Scientific reports,
7:14130, 2017.
0470B009 Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation of
multiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.
0470B010 (Toshiyuki Hayashida), Hiroshi Sasaki, Nobuyuki Hamada, Hideo Tatsuzaki, Natsuko Hatsusaka, Keiichi Akahane, Sumi Yokoyama:Issues behind Radiation Management of Workers at Fukushima Nuclear Power Plant of Tokyo Electric Power Company -From the Viewpoint of Radiation Exposure of the Ocular Lens and the Biological Effects
to the Lens-, Japanese Journal of Health Physics, 52:2;88-99, 2017.
Case Reports 0470D001 Nobuyuki Fujita, Teppei Shibata, Masamichi Fukuda, Kazuyuki Sasaki, Hiroshi Sasaki:An ease ｗith successful treatment of the endogenous endophthalmitis caused by Streptococcus anginosus endocarditis, Folia Japanica de
Ophthalmologica Clinica, 10:12;1007-1010, 2017.
Presentations at Conference
International Conference (Symposium) 0470H001 Masami Kojima:Acute ocular injuries caused by 40, 75, 95 GHz millimeter wave exposure, BioEM, Hangzhou,
2017.
International Conference (Presentations) 0470I001 Hiroshi Sasaki, Natsuko Hatsusaka, Hisanori Miyashita, Naoko Shibata, Yusuke Seki, Teppei Shibata, Hiromi Osada, Hidetoshi Ishida, Masami Kojima Eri Kubo:Crystalline lens change peculiar to diabetes, The Association for
Research in Vision and Ophthalmology, Baltimore, 2017.
- 72 - 0470I002 Hisanori Miyashita, Natsuko Hatsusaka, Yusuke Seki, Aya Nakano, Masami Kojima, Yutaka Kawakami, Eri Kubo, Hiroshi Sasaki:Influence of ocular UV exposure on risk of cataract in Chinese, The Association for Research in
Vision and Ophthalmology, Baltimore, 2017.
0470I003 Eri Kubo, Shinsuke Shibata, Teppei Shibata, Naoki Tanimura, Dhirendra P. Singh, Hiroshi Sasaki:FGF2-mediated induction of microRNA29c and its regulation of Tropomyosin, The Association for Research in Vision and
Ophthalmology, Baltimore, 2017.
0470I004 Shinsuke Shibata, Naoko Shibata, Teppei Shibata, Naoki Tanimura, Hiroshi Sasaki, Eri Kubo:Effects of proteoglycan decorin on lens epithelial cells, The Association for Research in Vision and Ophthalmology,
Baltimore, 2017.
0470I005 Naoko Shibata, Shinsuke Shibata, Teppei Shibata, Etsuko Kiyokawa, Hiroshi Sasaki, Eri Kubo:Comparison of gene expression profiles in human pterygium and UV-induced gene expressions in human conjunctival epithelium, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.
0470I006 Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P. Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.
0470I007 Hidetoshi Ishida, Norihiro Mita, Eri Kubo, Mai Kita, Aya Nakano, Yuuki Ukai, Ayako Okamoto, Naoko Shibata, Eri Kubo, Hiroshi Sasaki:Comparison of the postoperative stability of the three types of single-piece intraocular
lenses, The Association for Research in Vision and Ophthalmology, Baltimore, 2017.
0470I008 Eri Shibuya, Mai Sasaki, Norihiro Mita, Ayako Okamoto, Mai Kita, Hiromi Osada, Naoko Shibata, Yoriko Takahashi, Eri Kubo, Hiroshi Sasaki:Posterior capsular wrinkle in eyes with 2 types of 1-piece intraocular lens,
The Association for Research in Vision and Ophthalmology, Baltimore, 2017.
0470I009 (Bhavana Chhunchha), Eri Kubo, Hiroshi Sasaki, Dhirendra P. Singh:Switching of redox signaling by sulforaphane determines lens epithelial cells fate by hormetic mechanisms involving Prdx6/Nrf2 and Klf9 pathways, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.
0470I010 (Dhirendra P Singh), Bhavana Chhunchha, Prerna Singh, W Daniei Stamer, Eri Kubo:Stabilization of Prdx6 activity by targeted mutation of sumoylation sites protects trabecular meshwork cells from oxidative damage, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.05.
0470I011 (Yukihisa Suzuki), Masami Kojima, Maya Mizuno,Tsutomu Okuno, Masao Taki, J Chakarothai, Kensuke Sasaki, Kanako Wake, Souichi Watanabe, Hiroshi Sasaki:Estimation of the thresholds for corneal epithelium damage induced by millimeter-wave electromagnetic field exposure with a mathematical model based on CEM43℃
criterion, 32nd URSI GASS, Montreal, 2017.08.
0470I012 Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki:CREATING A SHORT- TERM STABLE ENVIRONMENT FOR RABBITS IN A CARGO VAN, 68th AALAS National Meeting, Austin,
2017.10.
0470I013 Hiroshi Sasaki, Ayako Okamoto, Naoko Shibata, Eri Shibuya, Norihiro Mita, Hidetoshi Ishida, Eri Kubo:Influence on toric intraocular lems axis by incision misalignment:a simulation study, European Society of Cataract &
Refractive Surgens, Lisbon, 2017.
0470I014 Masami Kojima, Yukihisa Suzuki, Kensuke Sasaki, Hiroshi Sasaki:Microwave radiation cataract, International
Conference on the Lens, Kona, 2017.
0470I015 Hisanori Miyashita, Natsuko Hatsusaka, Hiromi Osada, Teppei Shibata, Yusuke Seki, Yutaka Kawakami, Masami Kojima, Eri Kubo, Hiroshi Sasaki:Risk of five types of cataract in eyes with pseudoexfoliation syndrome,
International Conference on the Lens, Kona, 2017.
0470I016 Shinsuke Shibata, Naoko Shibata, Teppei Shibata, Hiroshi Sasaki, Eri Kubo:Expression of decorin, and its relation
to posterior capsular opacification, International Conference on the Lens, kona, 2017.
0470I017 Natsuko Hatsusaka, Hisanori Miyashita, Naoki Tanimura, Yoshikazu Nishino, Eri Kubo, Hiroshi Sasaki:Ocular UV
exposure and cataract risk in highly myopic eyes, International Conference on the Lens, Kona, 2017.
- 73 - 0470I018 Norihiro Mita, Aya Nakano, Yuuki Ukai, Ayako Takayama, Eri Sibuya, Mai Kita, Hiromi Osada, Hisanori Miyashita, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:Analysis of transparent lens formation in mid-and old-age by anterior
segment OCT, International Conference on the Lens, Kona, 2017.
0470I019 Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P Singh:Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, International
Conference on the Lens, Kona, 2017.
0470I020 Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi Sasaki, Eri Kubo:Knock-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.
- 74 - 0475 Department of Otorhinolaryngology
Faculty
Title Name Field of Specialization Professor MIWA Takaki Otorhinolaryngology, Head and Neck Surgery Associate Professor SHIGA Hideaki Rhinology, Olfactory disorders Senior Assistant Professor MIYAZAWA Toru Otorhinolaryngology, Otology Senior Assistant Professor YAO Toru Otology, Rhinology Senior Assistant Professor SAKAI Aya Sleep apnea syndrome Assistant Professor KINOSHITA Yuko Otorhinolaryngology Assistant Professor YAMAMOTO Junpei General otorhinolaryngology, Olfactory disorders Assistant Professor NODA Takuya General otorhinolaryngology Assistant Professor YAMADA Kentaro General otorhinolaryngology Assistant Professor INAGAKI Shingo General otorhinolaryngology Assistant Professor HARITA Masayuki General otorhinolaryngology
Keywords of Research
olfactory disorder, molecular imaging, virtual education for endoscopic nasal surgery, navigation surgery, audiology, sleep apnea & snoar surgery
Outline of Research
Basic and clinical research for diagnosis and treatment of olfactory disorders(Miwa, Shiga, Yao, Yamamoto, Yamada, Noda, Harita) New educational system for endoscopic sinus surgery(Miwa , Shiga, Yao) Clinical research for snoar and sleep apnea(Miwa, Sakai)
Publications
Originals 0475B001 Shiga Hideaki, Taki Junichi, Okuda Koichi, Watanabe Naoto, Tonami Hisao, Nakagawa Hideaki, Kinuya Seigo, Miwa Takaki:Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients
with idiopathic olfactory dysfunction., Scientific reports, 7:1;3581, 2017.
Reviews 0475C001 Noda Takuya, Tsuji Hiroyuki:Prevention of Frey's Syndrome Following a Parotid Gland Surgery with a Platysma
Flap, Practica Oto-Rhino-Laryngologica, 110:1;4-5, 2017.
Case Reports 0475D001 Shin Toki, Masatsune Itoh, Nobuhiro Okamoto, Azusa Kobayashi, Kentaro Yamada, Yuzo Shimode, Hiroyuki Tsuji, Takeo Shibata, Toshiyuki Sasagawa, Yutaka Saikawa:Multidisciplinary management of multiple endocrine neoplasia
type 1 during pregnancy, 53:3;905-908, 2017.
- 75 - Short Communications 0475E001 Yuzo Shimode, Hiroyuki Tsuji, Takahiro Fukuhara, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda, Kentaro Yamada, Kazuhiro Kishimoto, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takayuki Nojima, Hiromi Takeuchi:Examination of Selective Low-pressure Fine Needle Aspiration Cytology Under Ultrasound Guidance,
YONAGO ACTA MEDICA, 60:3;209-212, 2017.
Others 0475F001 (T.Hummel), K.L.Whitcroft, P.Andrews, A.Altundag, C.Cinghi, R.M.Costanzo, M.Damm, J.Frasnelli, H.Gudziol, N.Gupta, A.Haehner, E.Holbrook, S.C.Hong, D.Hornung, K.B.Hüttenbrink, R.Kamel, M.Kobayashi, I.Konstantinidis, B.N.Landis, D.A.Leopold, A.Macchi, T.Miwa, R.Moesges, J.Mullol, C.A.Mueller, G.Ottaviano, G.C.Passali, C.Philpott, J.M.Pinto, V.J.Ramakrishnan, P.Rombaux, Y.Roth, R.A.Schlosser, B.Shu, G.Soler, P.Stjärne, B.A.Stuck, J.Vodicka, A.Welge-Luessen:Position paper on olfactory dysfunction, RHINOLOGY, 54:1-
30, 2017.
Presentations at Conference
International Conference (Key Note Lecture) 0475G001 Takaki Miwa:Treatment of post-infectious olfactory dysfunction, International congress of ORL-HNS2017, Seoul, 2017.04. International Conference (Symposium)
0475H001 Takaki Miwa:How to set up a smell clinic, Rhinology world congress - Hong Kong 2017, Hong Kong, 2017.08.
0475H002 Takaki Miwa:Treatment of postinfectious olfactory dysfunction, Rhinology world congress - Hong Kong 2017, Hong
Kong, 2017.09.
0475H003 Hideaki Shiga:Thallium-201 based "olfacto-scintigraphy" for traumatic smell loss patients, Rhinology world
congress - Hong Kong 2017, Hong Kong, 2017.09.
0475H004 Yuzo Shimode, Hiroyuki Tsuji, Kazuhiro Kishimoto, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda, Kentaro Yamada, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takahiro Fukuhara:Examination of selective low- pressure fine needle aspiration cytology under ultrasound guidance, 2nd Congress of Asia-Pacific Society of
Thyroid Surgery, Naha, 2017.11.
International Conference (Presentations) 0475I001 Hideaki Shiga, Junichi Taki, Koichi Okuda, Naoto Watanabe, Hisao Tonami, Seigo Kinuya, Takaki Miwa: Correlation of thallium olfactory transport and olfactory bulb volume in patients with olfactory impairment after
upper respiratory infection, AChemS 39th Annual Meeting 2017, Florida, 2017.04.
0475I002 Takuya Noda, Hideaki Shiga, Kentaro Yamada, Hideaki Ninomiya, Takaki Miwa:Effects of herbal medicine on
regeneration of olfactory neurons in mice, Rhinology world congress - Hong Kong 2017, Hong Kong, 2017.09.
0475I003 Kentaro Yamada, Hideaki Shiga, Takuya Noda, Takaki Miwa, Hideaki Ninomiya:Effects of ovariecotmy on
regeneration of olfactory neuron in mice, Rhinology world congress - Hong Kong 2017, Hong Kong, 2017.09.
- 76 - 0485 Department of Head and Neck Surgery
Faculty
Title Name Field of Specialization Professor TSUJI Hiroyuki Head and neck oncology, Head and neck surgery Senior Assistant Professor SHIMODE Yuzo Head and neck oncology, surgery, Thyroid gland tumor research Assistant Professor KISHIMOTO Kazuhiro Head and neck surgery Assistant Professor KAWAKAMI Osamu Head and neck surgery
Keywords of Research
head and neck cancer, deglutition functional disorder, lymph node dissection, thyroid papillary carcinoma, fine needle aspiration cytology, chemoradiotherapy
Outline of Research
Development of surgical procedure for severe dysphagia (Tsuji, Shimode) New system for fine needle aspiration cytology in the medical equipment field by industry-academia-government cooperation (Tsuji, Shimode) Clinical study of cervical lymph node metastasis from thyroid carcinoma and the applicate of neck dissection (Tsuji, Shimode) Clinical study to evaluate response to chemoradiotherapy in lymph node metastasis (Tsuji, Shimode)
Publications
Originals 0485B001 Matoba Munetaka, Tuji Hiroyuki, Shimode Yuzo, Kondo Tamaki, Oota Kiyotaka, Tonami Hisao:The role of changes in maximum standardized uptake value of FDG PET-CT for post-treatment surveillance in patients with head and neck squamous cell carcinoma treated with chemoradiotherapy: preliminary findings, BRITISH JOURNAL
OF RADIOLOGY, 90:20150404, 2017.
Reviews 0485C001 Noda Takuya, Tsuji Hiroyuki:Prevention of Frey's Syndrome Following a Parotid Gland Surgery with a Platysma
Flap, Practica Oto-Rhino-Laryngologica, 110:1;4-5, 2017.
Case Reports 0485D001 Shin Toki, Masatsune Itoh, Nobuhiro Okamoto, Azusa Kobayashi, Kentaro Yamada, Yuzo Shimode, Hiroyuki Tsuji, Takeo Shibata, Toshiyuki Sasagawa, Yutaka Saikawa:Multidisciplinary management of multiple endocrine neoplasia
type 1 during pregnancy, 53:3;905-908, 2017.
Short Communications 0485E001 Yuzo Shimode, Hiroyuki Tsuji, Takahiro Fukuhara, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda, Kentaro Yamada, Kazuhiro Kishimoto, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takayuki Nojima, Hiromi Takeuchi:Examination of Selective Low-pressure Fine Needle Aspiration Cytology Under Ultrasound Guidance,
YONAGO ACTA MEDICA, 60:3;209-212, 2017.
- 77 - Presentations at Conference
International Conference (Symposium) 0485H001 Yuzo Shimode, Hiroyuki Tsuji, Kazuhiro Kishimoto, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda, Kentaro Yamada, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takahiro Fukuhara:Examination of selective low- pressure fine needle aspiration cytology under ultrasound guidance, 2nd Congress of Asia-Pacific Society of
Thyroid Surgery, Naha, 2017.11.
0485H002 Yuzo Shimode:Ultrasonography and FNA/Core needle biopsy, 2nd Congress of Asia-Pacific Society of Thyroid
Surgery, Naha, 2017.11.
- 78 - 0490 Department of Dermatology
Faculty
Title Name Field of Specialization Professor MOCHIZUKI Takashi Medical mycology, Dermatomycosis Associate Professor NISHIBU Akiko Immunology Senior Assistant Professor TAKEDA Kiminobu Medical mycology Senior Assistant Professor FUJII Toshiki Dermatopathology Assistant Professor ANZAWA Kazushi Medical mycology Assistant Professor USHIGAMI Tsuyoshi Medical mycology Assistant Professor HATTA Jyunko Image analysis Associate Professor WATANABE Seiji Medical mycology
Keywords of Research
fungi, dermatophytes, Candida speｃies, Sporothrix species, dematiaceous fungi, mitochondrial DNA, ribosomal DNA, phylogeny, taxonomy, molecular epidemiology, molecular typing, electron microscopy, dermatopathology, skin tumor, immunopathology, immunology, Langerhans cell,
Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology. We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data. We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to the epidemics. In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose the phylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understand those species as they are. In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical type of decubitus after surgical operations.
Publications
Originals 0490B001 S.Watanabe, K.Anzawa, T.Mochizuki:High prevalence of superficial white onychomycosis by Trichophyton
interdigitale in a Japanese nurcing home with a geriatric hospital., Mycoses, 60:634-637, 2017.
0490B002 (Tomoyuki Iwanaga), Tsuyoshi Ushigami, Kazushi Anzawa, Takashi Mochizuki:Pathogenic dermatophytes survive in
nail lesions during oral terbinafine treatment for tinea unguium, Mycopathologia, 182:673-679, 2017.
0490B003 T.Ushigami, K.Anzawa, T.Mochizuki:Molecular typing using polymorphisms of the polyketide synthase gene (PKS1)
of strains in Japan morphologically identified as Fonsecaea pedrosoi., The Journal of Dermatology, 44:36-42, 2017.
0490B004 J.Watanabe, K.Anzawa, T.Mochizuki:Molecular epidemiology of Japanese isolates of Microsporum canis based on
multilocus microsatellite typing fragment analysis, Japanese Journal of Infectious Diseases, 70:544-548, 2017.
- 79 - Reviews 0490C001 T. Mochizuki, K. Takeda, K. Anzawa.:Molecular markers useful for intraspecies subtyping and strain differentiation
of dermatophytes., Mycopathologia, 182:57-65, 2017.
Case Reports 0490D001 Tomoko Sakamoto, Asuka Kitayama, Takashi Mochizuki:A case of reticulohistiocytic granuloma, Practical
Dermatology, 39:163-166, 2017.
0490D002 (G.Tsuji), K.Takei, M.Takahara, T.Matsuda, T.Nakahara, K.Anzawa, T.Mochizuki, M.Furue, H.Uchi:Simultaneous
onset of sporotrichosis in mother and daughter., The Journal of Dermatology, 44:1068-1069, 2017.
0490D003 (A.Ito), N.Yamada, N.Tanaka, J.Kurai, K.Anzawa, T.Mochizuki, O.Yamamoto:Concurrent double fungal infections of the skin caused by Phialemoniopsis endophytica and Exophiala jeanselmei in a patient with microscopic
polyangitis, Acta Dermato-Venereologica, 97:1142-1144, 2017.
0490D004 (Y.Kawakami), S.Hirano, S.Mistui, M.Kuyama, A.Nishibu, K.Anzawa, T.Mochizuki:Case of inflammatory tinea corporis affecting the dorsal surface of the thumb in a nail salon technician, The Journal of Dermatology, 44:e294-
e295, 2017.
0490D005 Seiji Watanabe, Kazushi Anzawa, Takashi Mochizuki:Case of mycotic cyst caused by Scedosporium apiospermum developed liver dysfunction following administration of voriconazole, The Journal of Dermatology, 44:e296-e297,
2017.
Short Communications 0490E001 J Hatta, T Mochizuki:Successful treatment of plantar warts with topical glycolic acid, The Journal of Dermatology,
44:e134-e135, 2017.
- 80 - 0500 Department of Urology
Faculty
Title Name Field of Specialization Professor MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer Professor TANAKA Tatsuro kidney transplantation, endourology Professor SUZUKI Koji kidney stone disease, kidney transplantation, hyperparathyroidism Senior Assistant Professor CHIKAZAWA Ippei general urology Senior Assistant Professor MORITA Nobuyo general urology Assistant Professor SUGA Koudai general urology Assistant Professor INOUE Shinya general urology Assistant Professor NAKAZAWA Yusuke general urology Assistant Professor FUKUDA Yuko USHIMOTO Assistant Professor Chiharuko
Keywords of Research
chronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acute rejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate, crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer, bladder cancer, p53, urinary incontinence,
Outline of Research
clinical research on renal transplantation,mechanism of urolithiasis
Publications
Originals 0500B001 Ippei Chikazawa, Shinya Inoue, Yusuke Nakazawa, Dan Nakai, Nobuyo Morita, Tatsuro Tanaka, Yoshiharu Motoo, Katsuhito.Miyazawa:Clinical study on the efficacy and continuous docetaxel based chemotherapy treatment for
castration-resistant prostate cancer, 63:9;351-357, 2017.
0500B002 (Igor Sorokin), Charalampos Mamoulakis, Katsuhito Miyazawa, Allen Rodgers, Jamsheer Talati, Yair Lotan:
Epidemiology of stone disease across the world, World Journal of Urology, 35:1301-1320, 2017.
Case Reports 0500D001 Keiji Fujimoto, Masaru Nakagawa, Katsuaki Sato, Tatsuro Tanaka, Nobuhiko Miyatake, Keita Yamazaki, Yuko Tsuruyama, Yuki Okushi, Kazuaki Okino, Kiyotaka Mukai, Katsuhito Miyazawa, Hitoshi Yokoyama:A patient with tuberous sclerosis in whom dialysis was introduced due to hemorrhaging from oncocytic papillary renal cell
carcinoma, Journal of Japanese Society for Dialysis Therapy, 50:93-100, 2017.
- 81 - 0510 Department of Obstetrics and Gynecology
Faculty
Title Name Field of Specialization Gynecologic Pathology, Tumor Virology, Sexually Transmitted Professor SASAGAWA Toshiyuki Infection Research, Immunology Associate Professor TAKAKURA Masahiro gynecologic oncology, perinatal medicine Senior Assistant Professor TAKAGI Hiroaki perinatal medicine, reproductive medicine, gynecologic oncology Senior Assistant Professor FUJITA Satoko perinatal medicine, reproductive medicine (Additional Post) Assistant Professor SHIBATA Takeo perinatal medicine,reproductive medicine Assistant Professor OSAKA Yasuhiro perinatal medicine Assistant Professor SAKAMOTO Jinichi perinatal medicine, reproductive medicine
Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation, postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition and metabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms, mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis
Outline of Research
Publications
Originals 0510B001 T.Shibata, J.Sakamoto, Y.Osaka, N.Neyatani, S.Fujita, Y.Oka, T.akagi, H.Mori, H.Fujita, Y.Tanaka, T.Sasagawa: Myeloperoxidase in blood neutrophils during normal and abnormal menstrual cycles in women ofreproductive age,
Int J Lab Hematol, 39:169-174, 2017.
- 82 - 0510B002 M.Takahashi P.Mohan K.Mukai Y.Takeda T.Matsumoto K.Matsumura M.Takakura H.Arai T.Taguchi S.Maenosono: Magnetic Separation of Autophagosomes from Mammalian Cells Using Magnetic–Plasmonic Hybrid Nanobeads, ACS
Omega, 2:4929-4937, 2017.
Case Reports 0510D001 Shin Toki, Masatsune Itoh, Nobuhiro Okamoto, Azusa Kobayashi, Kentaro Yamada, Yuzo Shimode, Hiroyuki Tsuji, Takeo Shibata, Toshiyuki Sasagawa, Yutaka Saikawa:Multidisciplinary management of multiple endocrine neoplasia
type 1 during pregnancy, 53:3;905-908, 2017.
Presentations at Conference
International Conference (Presentations) 0510I001 T.Sasagawa, Y.Osaka, J. Sakamoto, T.Shibata, A.Hiroguchi, S.Fujita, H.Takagi, T.Maehama:Effectiveness of a novel ablation therapy using phenol for cervical or vaginal intraepithelial neoplasia (CIN/ VAIN), 31th International
Papillomavirus Conferenc, Capetown, 2017.02.
0510I002 A.Hiroguchi, Y.Osaka, J.Sakamoto, T.Shibata, H.Minato, T.Sasagawa:Identification of HPV infection type for
Squamous cell carcinoma, 31th International Papillomavirus Conference, Capetown, 2017.02.
0510I003 T.Sasagawa, J.Sakamoto, Y.Osaka, T.Shibata, S.Fujita, M.Takakura, H.Takagi:A new ablation therapy using liquid phenol for cervical and vaginal squamous intraepithelial lesions (SILs) , AOGIN 2017 Tokyo Meeting, Tokyo,
2017.10.
- 83 - 0520 Department of Anesthesiology and Perioperative Medicine
Faculty
Title Name Field of Specialization Professor TSUCHIDA Hideaki Cardiovascular effects of anesthetics Senior Assistant Professor OGAWA Masao Clinical anesthesia, Palliative medicine Senior Assistant Professor KIDA Hiromasa Clinical anesthesia, Pediatric anesthesia, Shock Senior Assistant Professor HONMA Keiko Clinical anesthesia, Palliative medicine Assistant Professor ARAKI Hideharu Clinical anesthesia Assistant Professor TAKANO Mami Clinical anesthesia Assistant Professor TANAKA Yasunori Clinical anesthesia Assistant Professor TAKAHARA Asami Clinical anesthesia Assistant Professor KANEKO Yuriko Clinical anesthesia Assistant Professor MORIKAWA Takanori Clinical anesthesia Assistant Professor YAMAOKA Yuko Clinical anesthesia, Palliative medicine Assistant Professor UEDA Keiko Clinical anesthesia Assistant Professor MATUBA Sho Clinical anesthesia Assistant Professor MIYAJIMA Saki Clinical anesthesia Assistant Professor OGAWA Miho Clinical anesthesia
Keywords of Research
anesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care, postoperative pain relief, sepsis, inducible nitric oxide synthase, nitric oxide
Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics in perioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics and prognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined the effects of septic shock on vasoreactivity in the rat thoracic aorta or the mesenteric arteriole.
Publications
Reviews 0520C001 Hideaki Tsuchida:The Reason the Japanese Society for Geriatric Anesthesia Initiated a Certification System,
Journal of Clinical Anesthesia (Japan), 41:6;854-856, 2017.
Case Reports 0520D001 Akiko Hiramatsu, Hiromasa Kida, Hideaki Tsuchida:Elective Surgery was Postponed in a Patient with Hematopoietic Malignancy due to Bleeding from the Insertion Site of an Epidural Catheter: A Case Report, The
Japanese Journal of Anesthesiology, 66:1;62-64, 2017.
- 84 - 0520D002 Masao Ogawa, Michiko Michibuchi Takanori Wagatsuma, Mikako Nishikawa, Yasuhiro Kawasaki, Hideaki Tsuchida, Kanako Teraguchi:A Case Whose Delirium Improved with Discontinuation of Continuous Deep Sedation Initiated
for Refractory Delirium at the End Stage of Cancer, Palliative Care Research, 12:1;501-505, 2017.
0520D003 Masao Ogawa, Hideaki Tsuchida:Effective treatment of glossopharyngeal neuralgia using steroid pulse therapy: a
case report, Journal of Japan Society of Pain Clinicians, 24:4;336-340, 2017.
Presentations at Conference
International Conference (Symposium) 0520H001 Masao Ogawa:Kampo Case Reporting in the Era of Evidence-based Medicine, World Congress for Integrative
Medicine and Health 2017, Berlin, 2017.
International Conference (Presentations) 0520I001 T.Morikawa, H.Tsuchida:Effects of ischemic preconditioning on tourniquet-induced reperfusion injury in
gastrocnemius muscles of rats, Annual Meeting of the American Society of Anesthesiolosits, Boston, 2017.
- 85 - 0540 Department of Physical and Rehabilitation Medicine
Faculty
Title Name Field of Specialization rehabilitation medicine, osteoporosis, disuse syndrome, higher brain Professor KAGECHIKA Kenji dysfunction Assistant Professor TORIGOE Keiichiro general neurosurgery
Keywords of Research
gait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neck fracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL,
Outline of Research
1)Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during walking cycle. 2)For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patient with osteoarthritis of the hip who underwent hip surgery． 3)We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about the outcome, then to improve this clinical pathway, for the patient to return home with satisfaction. 4)We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination of swallowing. Secondly, we are going to establish the standard of indication for swallowing training.
Publications
Originals 0540B001 Fumio Nogata, Yoko Kawamura, Taro Goto, Yasunai Yokota, William R.Walsh, Kenji Kagechika:Stiffness Estimation from Arterial Wall Vibration and its Application, International Journal of Computer and Information
Technology, 6:1;7-13, 2017.
0540B002 Keisuke Irie, Hirokatsu Iseki, Satomi Okamoto, Seiji Nisimura, Akio Kobe, Kenji Kagechika:Validity and
responsiveness of the Simple Test for Evaluating Hand Function, Hand Therapy, 30:1-6, 2017.
Case Reports 0540D001 Yasutaka Takagi, Hiroshi Yamada, Hidefumi Ebara, Hiroyuki Hayashi, Takeshi Iwanaga, Kengo Shimozaki, Yoshiyuki Kitano, Kagechika, Hiroyuki Tsuchiya:Thoracic spondylolisthesis and spinal cord compression in diffuse
idiopathic skeletal hyperostosis:a case report, Jornal of Medical Case Reports, 11:90, 2017.
Presentations at Conference
International Conference (Presentations) 0540I001 K.Kagechika:Validity and responsiveness of the Simple Test for Evaluating Hand Function, APFSSH 2017, Cebu,
2017.
- 86 - 0550 Department of Emergency Medicine
Faculty
Title Name Field of Specialization Professor WATOH Yukihiro Emergency, Emergency medical syctem, Disaster Medicine Senior Assistant Professor MASHIBA Satoru Emergency, Anaphylaxis Assistant Professor MURASAKA Kenshi Emergency, Neurosurgery Assistant Professor MORITA Hideki Emergency Assistant Professor WATANABE Atsushi Emergency Assistant Professor USHIMOTO Tomoyuki Emergency
Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care,
Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.
- 87 - 0570 Community Medicine
Faculty
Title Name Field of Specialization Professor KANDA Tsugiyasu Cardiovascular distase, Diabetes Mellitus, Mental distase Field of Specialization, Cardiology, General Practice, Professor KASAMAKI Yuji Electrocardiology, Arrhythmia, Echocardiography Senior Assistant Professor Community-based Medical Education，Community Medicine，General TAKAMURA Akiteru (Additional Post) Practice，General Paediatrics Assistant Professor USUDA Daisuke General Medicine (Additional Post)
Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy,
Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinical field. 1. The treatment of heart failure with myocarditis in an animal model. 2. The treatment trial of cytokine regulation in the atherosclerosis. 3. The cytokine treatment against chronic fatigue syndrome.
Publications
Originals 0570B001 Noda Yoko, Iinuma Yoshitsugu, Usuda Daisuke, Taga Mitsutoshi, Shinmachi Miyuki, Maeda Kazumi, Maeno Toshiko:Revising the Hygiene Maintenance of Urine Disposal Facilitated the Appropriate Indication of Urine
Collection, Japanese Journal of Environmental Infections, 32:1;23-28, 2017.
0570B002 Kawamura Kae, Iinuma Yoshitsugu, Usuda Daisuke, Hashimoto Aya, Matsumoto Masami, Tanaka Yoshi:Evaluation of automated urine particle analyzer, UF-5000, as a screening tool to identify Gram stainability of urinal
pathogens, Japanese Journal of Medical Technology, 66:5;516-523, 2017.
0570B003 Takamura Akiteru, Ito Sayori, Maruyama Kaori, Ryo Yusuke, Saito Manami, Fujimura Shuhei, Ishiura Yuna, Hori Ariyuki:Quality of basic life support education and automated external defibrillator setting in schools in Ishikawa,
Japan, PEDIATRICS INTERNATIONAL, 59:3;352-356, 2017.
0570B004 Takamura Akiteru, Misaki Hidekazu, Takemura Yousuke:Community and Interns' Perspectives on Community-
Participatory Medical Education: From Passive to Active Participation., Family medicine, 49:7;507-513, 2017.
Reviews 0570C001 A.Takamura, M.Matsumoto, S.Ishikawa:Rural Health in Japan: Past and future., Rural and Remote Health,
17:4;4521-, 2017.
Case Reports 0570D001 Mizuno Takuro, Kiyosawa Jun, Fukuda Akihiro, Watanabe Seiji, Kurose Nozomu, Nojima Takayuki, Kanda Tsugiyasu:Infective endocarditis following tumor necrosis factor-α antagonist therapy for management of psoriatic erythroderma: a case report, Journal of medical case reports, 11:1;35, 2017.
- 88 - 0570D002 Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda:Gastroenteritis in Japanese Females Caused by Shigella flexneri without Definite. Infection Route: A Case Report and Mini-Review of Literature, Journal Clinical Case Reports,
7:9;10001021, 2017.
0570D003 A.Takamura, R.Sangen, Y.Furumura, D.Usuda, Y.Kasamaki, T.Kanda:Diagnosis of myxedema coma complicated by
renal failure: a case report, Clinical Case Reports, 5:4;399-402, 2017.
0570D004 Akiteru Takamura, Ariyuki Hori:Recurrent Translent Perivascular Inflammation of the Carotid artery syndrome
with temporary carotid plaque on ultrasonography: a case report, Clinical Case Reports, 5:11;1847-1851, 2017.
0570D005 Daisuke Usuda, Masahisa Arahata, Kento Takeshima, Ryusho Sangen, Akiteru Takamura, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma, Tsugiyasu Kanda:A Case of Diffuse Large B-Cell Lymphoma Mimicking Primary
Effusion Lymphoma-Like Lymphoma, Case Reports in Oncology, 10:1013-1022, 2017.
- 89 - 0575 Department of Gastroenterological Endoscopy
Faculty
Title Name Field of Specialization Diagnosis for esophagus, gastro-intestine, colon, liver & bileduct Professor ITO Tohru disease. Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Professor URASHIMA Sachio Diagnosis for esophagus, Hepato-biliary-pancreatic treatment Diagnosis for esophagus, gastro-intestine, colon, disease. Associate Professor KITAKATA Hidekazu Endoscopical treatment of its disease,especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Senior Assistant Professor KAWAURA Ken Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Senior Assistant Professor HAMADA Kazu Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Assistant Professor OKAMURA Hideyuki Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Assistant Professor AZUKISAWA Sadafumi Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Assistant Professor KOBAYASHI Rika Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer Diagnosis for esophagus, gastro-intestine, colon, disease. Assistant Professor KAMAI Junji Endoscopical treatment of its disease, especially, superficial type esophageal cancer, early gastric cancer, early colon cancer
Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR
Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon) 2.A study for endoscopical treat ment of early digestive organ cancer.(Esophagus,Stomach,Colon) 3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)
Publications
Original 0575B001 K.Kawaura, T.Itoh, K.Hamada, H.Kitakata, S.Azukisawa, H.Okamura, S.Urashima, M.Sakurai, M.Ishizaki:Selection of Methods for Percutaneous Endoscopic Gastrostomy(PEG)that is more Safety and Useful Techniques on the
Patients., CLINICAL INVESTIGATION, 7:3;111-118, 2017.
- 90 - Presentations at Conference
International Conference (Key Note Lecture) 0575G001 T.Ito:Standard Endoscopy Diagnosis & Treatment of Early Gastric Cancer in Japan, The 19th Japan-Russia
Endoscopy Symposium, ST PETERSBURG, 2017.
0575G002 T.Ito:Early Gastric Cancer Managiment:Japanese Experience, Yaroslavl Endoscopy Symposium 2017, Yaroslavl,
2017.
International Conference (Presentations) 0575I001 Tohru Itoh, Ken Kawaura, Kazu Hamada, Hidekazu Kitakata, Sadafumi Azukisawa, Rika.Kobayashi:Can the Percutaneous Endoscopic Gastrostomy(PEG)become the untrition care to change oral, ENDO2017, Ｈｙｄｅｒａｂａｄ,
2017.02.
- 91 - 0577 Department of Cardiovascular Intervention
Faculty
Title Name Field of Specialization Professor KITAYAMA Michihiko Ischemic heart disease, Coronary intervention Associate Professor TSUCHIYA Taketsugu Assistant Professor KITAGAWA Katsuhide
Publications
Originals 0577B001 Kamioka Norihiko, Soga Yoshimitsu, Kuramitsu Shoichi, Iida Osamu, Hirano Keisuke, Suzuki Kenji, Kawasaki Daizo, Yamaoka Terutoshi, Suematsu Nobuhiro, Shintani Yoshiaki, Miyashita Yusuke, Takahashi Hiroki, Tsuchiya Taketsugu, Shinozaki Norihiko, Okazaki Shinya, Ando Kenji:Clinical outcomes of balloon angioplasty alone versus nitinol stent implantation in patients with small femoropopliteal artery disease: Observations from the Retrospective Multicenter Analysis for Femoropopliteal Stenting (REAL-FP)., Catheterization and cardiovascular
interventions, 90:5;790-797, 2017.
0577B002 (K.Suzuki), Y.Mizutani, Y.Soga, O.Iida, D.Kawasaki, Y.Yamauchi, K.Hirano, R.Koshida, D.Kamoi, J.Tazaki, M.Higashitani, Y.Shintani, T.Yamaoka, S.Okazaki, N.Suematsu, T.Tsuchiya, Y.Miyashita, N.Shinozaki, H.Takahashi, N.Inoue:Efficacy and Safety of Endovascular Therapy for Aortoiliac TASC D Lesions., Angiology,
68:1;67-73, 2017.
0577B003 M.Watanabe, Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, M.Wakasa , R.Saito, H.Aoki, K.Fujibayashi, T.Tsuchiya, H.Nakanishi, K.Saito, M.Takeuchi, K.Kajinami:Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived
advanced glycation end products., Journal of cardiology, 69:4;625-631, 2017.
0577B004 Takamura Taka-aki, Tsuchiya Taketsugu, Oda Minako, Watanabe Makoto, Saito Ryuhei, Sato-Ishida Ryoko, Akao Hironobu, Kawai Yasuyuki, Kitayama Michihiko, Kajinami Kouji:Circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) as a novel predictor of clinical outcome after endovascular therapy in patients with
peripheral artery disease (PAD), ATHEROSCLEROSIS, 263:192-197, 2017.
0577B005 Soga Yoshimitsu, Takahara Mitsuyoshi, Iida Osamu, Yamauchi Yasutaka, Hirano Keisuke, Fukunaga Masashi, Zen Kan, Suzuki Kenji, Shintani Yoshiaki, Miyashita Yusuke, Tsuchiya Taketsugu, Yamaoka Terutoshi, Ando Kenji: Efficacy of CilostAzol for Below-the-Knee Artery Disease after Balloon AnGioplasty in PatiEnts with Severe Limb
Ischemia (CABBAGE Trial)., Annals of vascular surgery, 45:22-28, 2017.
- 92 - 0580 Department of Oral and Maxillofacial Surgery
Faculty
Title Name Field of Specialization oral and maxillofacial surgery, temporomandibular joint disorders, oral Professor SEGAMI Natsuki cancer, orthognathic surgery Associate Professor MATSUMOTO GouichiBone Regeneration, Biomaterials, Oral Cancer Associate Professor ISHIBASHI Hiroaki Oral tumor, Oral Pathology Associate Professor DEMURA Noboru orthodontics, stomatology Senior Assistant Professor KATO Takao Oral cavity, Kampo medicines, Dental pharmacology Assistant Professor KATO Koichiro Oral tumor Assistant Professor HASUMOTO Miho Orthodontics
Keywords of Research
stomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonance imaging, oral cancer, metastasis, orthognathic surgery, kampo medicines, dental pharmacology
Outline of Research
1. Basic and clinical research for disorders of temporomandibular joins. 2. Molecular biological research for growth and metastasis of tumors in oral region. 3. Pathophysiological research for abnormal development of oral and maxillofacial region. 4. Research for surgical orthognathics for jaw deformity. 5. Integration mechanisms of oral sensory information in the central nervous systems. 6. Studies on the pharmacological mechanism of Kampo medicine.
Books
0580A001 (Hiroshi Sakagami), Takao Kato, Kunihiko Fukuchi, Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima, Hirokazu Ohno, Masaji Yamamoto:Applicability of Licorice Extracts for Treatment of Oral Diseases, Evaluated by Simplified In Vitro Assay Systems with Oral Cells, Biological Activities and Action Mechanisms of Licorice
Ingredients (Hiroshi.Sakagami), 91-106, InTech, Croatia, 2017.
Publications
Originals 0580B001 (Naotoshi Sugimoto), Hiroaki Ishibashi, Hiroyuki Nakamura, Akihiro Yachie, Takako Ohno-shosaku:Hypoxia-
induced inhibition of the endocannabinoid system in glioblastoma cells, Oncology Reports, 38:3702-3708, 2017.
Case Reports 0580D001 Noboru.Demura, Miho.Hasumoto, Taichi.Demura:A Case of Orthodontic Treatment for a Patient with Occlusal
Abnormality Due to Epileptic Seizure, Journal of Dental and Oral Health, 3:090, 2017.
0580D002 Natsuki Segami:A Case of Ameloblastoma Recurred 25 Years after Surgery, Journal of Dentistry and Oral Biology,
2:1085, 2017.
- 93 - Presentations at Conference
International Conference (Key Note Lecture) 0580G001 Hiroaki Ishibashi:Inhibition of Acute Inflammation by Gene Therapy after Implant Placement, The 8th Conference
of Asian International Association of Dental Traumatology, Bangkok, 2017.11.
- 94 - 0590 Department of Regenerative Medicine
Faculty
Title Name Field of Specialization SHIMODAIRA Professor Regenerative Medicine Shigetaka Assistant Professor KOYA Terutsugu Regenerative Medicine
Keywords of Research
Dendritic cell-based vaccination, Cancer immunotherapy, Regenerative medicine using adipose tissue-derived stem cells, Genomic medicine
Outline of Research
Researchers of the Department of Regenerative Medicine are spearheading the era of personalized medicine by developing treatments that harness the power of immune cells and stem cells. •Clinical investigation using dendritic cell-based cancer vaccines in accordance with the Good Gene, Cellular, and Tissue- based Products Manufacturing Practice (GCTP) standards •Contribution to the development of regenerative medicine technology using adipose tissue-derive stem cells •Genomic Regenerative Medicine
Publications
Originals 0590B001 Terutsugu Koya, Ryu Yanagisawa, Yumiko Higuchi, Kenji Sano, Shigetaka Shimodaira:Interferon-α-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas LIgand Pathway-mediated Killer Activity,
SCIENTIFIC REPORTS, 7:42145, 2017.
0590B002 Koido S, Okamoto M , Kobayashi M, Shimodaira S, Sugiyama H:Significance of Wilms tumor 1 antigen as a canser
vaccine for pancreatic cancer, Discovery Medicine, 130:41-49, 2017.
Case Reports 0590D001 Sakai K, Shimodaira S, Maejima S, Sano K, Higuchi Y, Koya T, Sugiyama H, Hongo K:Clinical effect and immunological response in patients with advanced malignant glioma treated with WT1-pulsed dendritic cell-based
immunotherapy: A report of two cases., Interdisciplinary Neurosurgery, 9:24-29, 2017.
Presentations at Conference
International Conference (Presentations) 0590I001 Terutsugu Koya, Shigetaka Shimodaira:IFN-α inducible dendritic cells matured with OK-432 exhibit professional antigen-presentation and anti-tumor activity, 5th Annual Meeting of the International Cytokine & Interferon
Society, Kanazawa, 2017.10.
- 95 -
School of Nursing
8010 Fundamental Nursing
Faculty
Title Name Field of Specialization Professor SAKAI Keiko Nursing education , Nursing skills Professor TAKIUTI Takako Nursing history, Nursing skill Associate Professor MATSUI Yuko Nursing skill Senior Assistant Professor SUGIMORI Chiyoko Nursing skill Assistant Professor OKAYAMA Miki Patient education for diabetes Assistant Professor MIYANAGA Aiko Wound Care Nursing, Nursing skills
Keywords of Research
fundamental nursing, nursing skills, nursing education, communication skills, skin care, wound care
Outline of Research
1. Verification of nursing skills 2. Study of nursing education
Publications
Originals 8010B001 (Maiko Oya), Ryoko Murayama, Makoto Oe, Koichi Yabunaka, Hidenori Tanabe, Toshiaki Takahashi, Yuko Matsui, Eiko Otomo, Chieko Komiyama, Hiromi Sanada:Continuous thermographic observation may predict extravasation
in chemotherapy-treated patients, European Journal of Oncology Nursing, 28:56-61, 2017.
8010B002 Aiko Miyanaga:Transient Vascularization Promotes Proliferation and Cartilage-formation of Perichondrial
Progenitor Cells, 42:1;24-31, 2017.
8010B003 Yuko Matsui, Ryoko Murayama, Hidenori Tanabe, Makoto Oe, Yoshiharu Motoo, Takanori Wagatsuma, Michiko Michibuchi, Sachiko Kinosita, Keiko Sakai, Chizuko Konya, Junko Sugama, Hiromi Sanada:Evaluation of the predictive validity of thermography in identifying extravasation with intravenous chemotherapy infusions, Journal of
Infusion Nursing, 40:6;367-374, 2017.
- 96 - 8040 Maternity Nursing・Midwifery
Faculty
Title Name Field of Specialization Professor YANO Keiko Matenity Nursing, Midwifery Senior Assistant Professor BODA Hitomi Matenity Nursing，Midwifery Senior Assistant Professor IWATANI Kumiko Matenity Nursing，Midwifery Senior Assistant Professor YAMAZAKI Chisato Maternity Nursing, Midwifery
Keywords of Research
Practice, Pregnancy, Midwife, Maternity Nursing, perinatal, after childbirth, breastfeeding, parenting stress maternity Nursing, Mother and child nursing, Child care, Mother, Mother-child relation, Dioxin
Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care, Dioxin.
Presentations at Conference
International Conference (Presentations) 8040I001 K.Iwatani, K.Shimada, K.Kanamori, M.Izuhara, S.Yoshida:Analysis of the causes and strategies for preventing incidents occurring during skilled birth attendant training using an RCA approach, 20th East Asian Forum of
Nursing Scholars, Hong Kong, 2017.
8040I002 Chisato Yamazaki:Challenges of clinical recordings using electronic partograms in Japan, 31st ICM Triennial
Congress, Toronto, 2017.06.
8040I003 Keiko Yano, Maya Okuda, Sanfa Shin3, Xenia Fukuda, Yuki Mori, Kyoka Yuraku, Yoko Natsuyama, Rumi Okamoto, Yumi Kanbara,Chiharu Sugiyama, Mitsuyo Taniguchi:Implementation and Effectiveness of Adolescent Education Peer Support for University Students as Carried Out by Midwife Students, 31st ICM Triennial Congress,
Toronto, 2017.
- 97 - 8050 Pediatric Nursing
Faculty
Title Name Field of Specialization Senior Assistant Professor HASHI Shinobu Single mother, asthma, child, belief, parenting stress Prevention of Maltreatment, Family Nursing in Child＆Maternal Assistant Professor TERAI Takahiro Health Care Assistant Professor ISHII Kazumi personal hygiene care
Keywords of Research
school children, health promotion, families with a young child, child with a developmental disorder, rating scale for family's problem-solving ability, intervention program for families, maltreatment, abuse, assessment,
Outline of Research
1.Psychometric development of a rating scale for family’s problem-solving ability with a young child with a developmental disorder (FPAYCDD) 2.Study of the efficacy of a support program for families with a young child with a developmental disorder 3.Study of the efficacy of Lifestyle-improvement Program among Elementary School Children 4.Study of the system for carrying out abuse prevention
- 98 - 8060 Adult Nursing
Faculty
Title Name Field of Specialization Professor KONYA Chizuko Wound Care, Stoma care, Continence care Professor OBATA Mitsuko Critical care Associate Professor MURAKADO Naoko Chronic nursing，Diabetes nursing Senior Assistant Professor KINOSHITA Sachiko Wound Care, Stoma care, Continence care Senior Assistant Professor KITAMURA Yoshiko Cancer Nursing Assistant Professor ASANO Kimi Wound Care Assistant Professor Natsuko Yamada Critical Care
Keywords of Research
Wound care, Stoma care, Continence care, Cronic Disease Nursing, Cancer Nursing, Terminal Care, Critical Care
Outline of Research
Clinical Medical-Surgical Nursing.
Publications
Originals 8060B001 (Tamae Urai), Kimi Asano, Yukari Nakajima, Kanae Mukai, Toshio Nakatani:Effectiveness of using an ostomy skin
barrier/wafer as a splint to maintain the shapes of circular cutaneous wounds in obese mice, 15:2;57-61, 2017.
8060B002 Yuko Matsui, Ryoko Murayama, Hidenori Tanabe, Makoto Oe, Yoshiharu Motoo, Takanori Wagatsuma, Michiko Michibuchi, Sachiko Kinosita, Keiko Sakai, Chizuko Konya, Junko Sugama, Hiromi Sanada:Evaluation of the predictive validity of thermography in identifying extravasation with intravenous chemotherapy infusions, Journal of
Infusion Nursing, 40:6;367-374, 2017.
Reviews 8060C001 Chizuko Konya, Mizuho Endo, Junko Sugama:Improving the quality of care for peristomal skin disorders using
information and communications technology, Journal of Nursing Science and Engineering, 4:1;15-20, 2017.
Presentations at Conference
International Conference (Presentations) 8060I001 (E.Hirayama), Y.Kitamura:The nurses' structure of concern when providing care to patients who have been informed about cancer recurrence or metastasis in Japan, 14th Annual AAPINA National Conference, Honolulu,
2017.
- 99 - 8070 Gerontological Nursing
Faculty
Title Name Field of Specialization Professor HIRAMATSU Tomoko community/elderly nursing science Associate Professor KOIZUMI Yumi community/elderly nursing science Assistant Professor HASHIMOTO Tomoe community/elderly nursing science
Keywords of Research
gerontological nursing, tactile care, people with dementia and their families, menopausal women, elderly volunteers in the community, learning experience with reality, analyzing the learning effects, frailty in elderly community-dwelling, creation of personal plans for dementia, dementia enlightenment lecture, foot care, care workers, long-term care facilities, bathing care
Outline of Research
Effectiveness verification of tactile care interventions （for people with dementia and their families 、menopausal women, etc.）、Study of teaching methods Geriatric Nursing (improvement of teaching methods , analysis of learning effects , etc.)、 Association between hypertension status and the screening test for frailty in elderly community-dwelling、Thoughts on “Creation of personal plans for dementia” in the dementia enlightenment lecture for healthy elderly individuals、Foot care for the elderly、Study of bathing care in elderly long-term care facilities、Study on the cooperation of nurse and care worker
Publications
Originals 8070B001 Morita Takuro, Okuno Tazuo, Himeno Taroh, Watanabe Keisuke, Nakajima Kumie, Koizumi Yumi, Yano Hiroshi, Iritani Osamu, Okuro Masashi, Morimoto Shigeto:Glycemic control and disability-free survival in hypoglycemic agent-treated community-dwelling older patients with type 2 diabetes mellitus., Geriatrics & gerontology international, 17:1858-1865, 2017.
8070B002 (Shizuko Omote), Arisu Watanabe, Tomoko Hiramatsu, Emiko Saito, Masami Yokogawa, Rie Okamoto, Chiaki Sakakibara, Akie Ichimori, Kaoru Kyota, Keiko Tsukasaki:A foot-care program to facilitate self-care by the
elderly: a non-randomized intervention study, intervention study BMC Research Notes, 10:586, 2017.
Case Reports 8070D001 Tomoe Hashimoto, Yumi Koizumi, Yoko Iwamoto, Tomoko Hiramatsu:Analysis of nursing sutudent's report in experiential exercises for learning among elderly people with dementia, Journal of Japanese Society for Dementia
Care, 15:4;848-856, 2017.
Short Communications 8070E001 Tomoe Hashimoto, Kazuyo Kawasima:Investigation into the Actual Conditions of Bathing Care System in Long-
term Care Facilities, Journal of Japan Academy of Gerontological Nursing, 22:1;115-122, 2017.
- 100 - 8080 Public Health Nursing
Faculty
Title Name Field of Specialization Professor NAKASHIMA Motoko public health nursing School hygiene Industrial health Senior Assistant Professor IKEUCHI Satomi public health nursing Senior Assistant Professor NAKADA Yukari public health nursing
Keywords of Research
Public health nursing-care activity, Public health nursing education, Health promotion, activity of cmmunity organization, Non-smoking education, School hygiene, Industrial health,
Outline of Research
The Public Health nursing study field aims at the science-of-nursing research which can contribute to improvement in the residents of the area, especially the quality of a life of people with health disturbance, part of a drug abuse prevention program for junior high school student and health maintenance.
Presentations at Conference
International Conference (Presentations) 8080I001 (Yusuke Kurebayashi), Satomi Ikeuchi, Aiko Hamada:Does self-focus differ between psychiatric and general
nurses? A cross-sectional study, The 20th EAFONS, Hong Kong, 2017.
8080I002 (Tomomi Goda), Satomi Ikeuchi, Yusuke Kurebayashi, Aiko Hamada, Toshiyuki Kihara:The State of Career Support Needs for New Faculty Members for Nursing Programs in Universities in Japan, The3th Conference on Public Health in Asia, Hiroshima, 2017.
8080I003 Satomi Ikeuchi, Tomomi Goda, Yusuke Kurebayashi, Aiko Hamada, Toshiyuki Kihara:Fundamental Capabilities of New Faculty Members for Nursing Programs, The3th Conference on Public Health in Asia, Hiroshima, 2017.
8080I004 （Yusuke Kurebayashi）,Tomomi Goda, Satomi Ikeuchi , Aiko Hamada, Toshiyuki Kihara:Differences in Perceived Need for Sappot Among New Nursing Teachers Working in aJapanese Nursing College Based on the Years of Experience, The3th Conference on Public Health in Asia, Hiroshima, 2017.04.
- 101 - 8085 Psychiatric and Mental Health Nursing
Faculty
Title Name Field of Specialization Professor FUKASAWA Yuko Mental health, Psychiatric Nursing life-world led care, patient-nurse interrelationship, empathy, Senior Assistant Professor TANAKA Koji psychiatric and mental health nursing Reducing the use of coercive measures, Strength-based nursing for Senior Assistant Professor NAGAYAMA Yutaka psychiatric patients Assistant Professor ARAI Satomi Mental health nursing, Concordance
Keywords of Research
depression, suicide prevention, therapeutic nursing, narrative approach, life-world led care, patient-nurse interrelationship, empathy, psychiatric and mental health nursing, reducing the use of coercive measures, physical restraint, seclusion, Strengths model, Emotion Modulation Therapy
Outline of Research
The purpose of our study is to clarify the suicide prevention effect for the depression people by Narrative approach and Emotion Modulation Therapy(EMT). We are trｙing the effect of these methods as new therapeutic nursing for depression people between our nursing clinic in Japan and Griffth University clinic in Australia.
Presentations at Conference
International Conference (Key Note Lecture) 8085G001 Tanaka.K:Trauma and Recovery, The 8th Joint scientific Meeting 2017 between KMU and HUST-TMC, Wuhan,
2017.
- 102 - 8090 Home Care Nursing
Faculty
Title Name Field of Specialization Professor MAEDA Shuko home care, home health care nurse home care nursing, home care nursing teaching method, discharge Senior Assistant Professor KOHNO Yumiko support Assistant Professor NAKAI Hisao Home healthcare,Disaster Nursing,Care Management Assistant Professor FUKUDA Moriyoshi Nursing care of pressure uler，Home care
Keywords of Research
home healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education, education program, Psychiatric Disorder, Community besed Workshop, Recoverry"consept
Outline of Research
In this article, we syowed clearly that the Community besed Work shops for Persons with Psychiatric Disorder, where introduced Recoverry"consept prevent the exclusion and separation from the community as functioned of the psychatric service institution in the community. Practice and restructuring of the infection control edcation program for home visiting nurses
Presentations at Conference
International Conference (Presentations) 8090I001 Y Kohno, S Sakurai:Relationship between impulses and stress when providing daily care among care workers
working in group homes in Japan, The 20th EAFONS, Hong Kong, 2017.
- 103 - 8100 Medical Science
Faculty
Title Name Field of Specialization Professor IWAI Kunimitsu Geriatrics, Circulation, Cell Biology Professor KOHNO Hiroyuki Experimental Pathology, Tumor immunology Professor MORIKAWA Yuko Cardiovascular epidemiology, occupational medicine Study of Cataractogenesis mechanisms, Relation of the intraocular Professor KOJIMA Masami temperature during infrared exposure and environmental temperature
Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Kojima/electromagnetic radiation, M. Kojima/ultraviolet exposure, M. Kojima/infrared rays exposure
Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing vasodilators. M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays) exposure. K. Iwai:Role of the nuclear matrix associated proteins in the regulation of gene expression of the cardiovascular cells. Y.Morikawa:Epidemiology of work related disease, Social epidemiology
Publications
Originals 8100B001 (Koshi Nakamura), Masaru Sakurai, Yuko Morikawa, Shin-ya Nagasawa, Katsuyuki Miura, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Motoko Nakashikma, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Serum ferritin, insulin resistance, and β-cell dysfunction: a prospective study in normoglycemic Japanese men, Experimental and
clinical endocrinology & diabetes, 125:1;12-20, 2017.
8100B002 M.Sakurai, K.Yoshita, K.Nakamura, K.Miura, T.Takamura, S-Y.Nagasawa, Y.Morikawa, T.Kido, Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, M.Ishizaki, H.Nakagawa:Skipping breakfast and 5-year changes in body mass
index and waist circumference in Japanese men and women, Obesity Science & Practice, 3:2;162-170, 2017.
8100B003 Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki, Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose, Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.
Presentations at Conference
International Conference (Symposium) 8100H001 Masami Kojima:Acute ocular injuries caused by 40, 75, 95 GHz millimeter wave exposure, BioEM, Hangzhou,
2017.
- 104 - International Conference (Presentations) 8100I001 Shinya Nagasawa, Katsuyuki Miura, Masaru Sakurai, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yasushi Suwazono, Kazuhiro Nogawa, Hideaki Nakagawa:Longitudinal association between body weight change and 6-year
change of blood pressure in Japanese men, EPI|LIFESTYLE2017, Portland, 2017.03.
8100I002 Hiroshi Sasaki, Natsuko Hatsusaka, Hisanori Miyashita, Naoko Shibata, Yusuke Seki, Teppei Shibata, Hiromi Osada, Hidetoshi Ishida, Masami Kojima Eri Kubo:Crystalline lens change peculiar to diabetes, The Association for
Research in Vision and Ophthalmology, Baltimore, 2017.05.
8100I003 Hisanori Miyashita, Natsuko Hatsusaka, Yusuke Seki, Aya Nakano, Masami Kojima, Yutaka Kawakami, Eri Kubo, Hiroshi Sasaki:Influence of ocular UV exposure on risk of cataract in Chinese, The Association for Research in
Vision and Ophthalmology, Baltimore, 2017.05.
8100I004 (Yukihisa Suzuki), Masami Kojima, Maya Mizuno,Tsutomu Okuno, Masao Taki, J. Chakarothai, Kensuke Sasaki, Kanako Wake, Souichi Watanabe, Hiroshi Sasaki:Estimation of the thresholds for corneal epithelium damage induced by millimeter-wave electromagnetic field exposure with a mathematical model based on CEM43℃
criterion, 32nd URSI GASS, Montreal, 2017.08.
8100I005 Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki:CREATING A SHORT- TERM STABLE ENVIRONMENT FOR RABBITS IN A CARGO VAN, 68th AALAS National Meeting, Austin,
2017.10.
8100I006 Masami Kojima, Yukihisa Suzuki, Kensuke Sasaki, Hiroshi Sasaki:Microwave radiation cataract, International
Conference on the Lens, Kona, 2017.12.
8100I007 Hisanori Miyashita, Natsuko Hatsusaka, Hiromi Osada, Teppei Shibata, Yusuke Seki, Yutaka Kawakami, Masami Kojima, Eri Kubo, Hiroshi Sasaki:Risk of five types of cataract in eyes with pseudoexfoliation syndrome,
International Conference on the Lens, Kona, 2017.12.
- 105 -
Department of General Education
8610 Natural Sciences
Faculty
Title Name Field of Specialization Associate Professor SHOJI Hiroki Developmental Biology, Molecular Biology, Biochemistry HASHIMOTO Associate Professor Radiation Biology, Cell Biology Mitsumasa Associate Professor IIDA Yasuo Function algebra,Function space Senior Assistant Professor ARIKAWA Tomohiro Immunology, Developmental Biology Senior Assistant Professor OKUDA Koichi Fixed-quantity rating system in the heart nuclear medicine Senior Assistant Professor MAEDA Masayo Molecular oncology, Metastasis of Cancer Cells Senior Assistant Professor INOUE Tomoki Graph theory in toplogy
Keywords of Research
Bertrand curveMannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic fieldMannheim curve, Frenet frame, graph theory in topology, topological polyhedron, , Nuclear medicine Nuclear cardiology, Imaging, Image processingSPECT, DNA repair, 53BP1, NHEJ, HR, Ionizing Radiation, DNA double strand breaks (DSBs), Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2), , ultrastructure, pharynxspongemetamorphosis, immunoelectron microscopy, neurosynapsneurosecretory cell, lectin, galectinβ-galactoside, Xenopusdevelopment, placenta
Outline of Research
1)Functional analysis of Galectins a family of ・-galactosides binding proteins. a）Roles of Galectins in animal development. b）Roles of Galectins in the placentation and immune tolerance. Hashimoto:Function of DNA repair enzymes especially protection mechanisms against DNA double strand breaks induced ionizing radiation especially protection mechanisms against DNA double strand breaks induced ionizing radiation Okuda:The aim of our research is to develop a computer algorithm for the quantitative assessment of myocardial perfusion and sympathetic nerve activity in the nuclear cardiology. Inoue:We extend the Graph Theory and define a topologicalpolyhedron which coverd on closed surface of genus g. We give characterizations and example of the topological polyhedron. MAEDA:Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the ctivity of Rho family GTPases. Our studies have indicated that RhoGDIβLyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.Further investigation of the details of RhoGDIβ's role in cancer progression and metastasis is important. It will lead to a better treatment for cancer.
Publications
Originals 8610B001 Shiga Hideaki, Taki Junichi, Okuda Koichi, Watanabe Naoto, Tonami Hisao, Nakagawa Hideaki, Kinuya Seigo, Miwa Takaki:Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients
with idiopathic olfactory dysfunction., Scientific reports, 7:1;3581, 2017.
8610B002 Okuda Koichi, Nakajima Kenichi, Kikuchi Akihiro, Onoguchi Masahisa, Hashimoto Mitsumasa:Cardiac and Respiratory Motion-induced Artifact in Myocardial Perfusion SPECT, Annals of Nuclear Cardiology, 3:1;88-93,
2017.
- 106 - 8610B003 (Nakajima Kenichi), Kudo Takashi, Nakata Tomoaki, Kiso Keisuke, Kasai Tokuo, Taniguchi Yasuyo, Matsuo Shinro, Momose Mitsuru, Nakagawa Masayasu, Sarai Masayoshi, Hida Satoshi, Tanaka Hirokazu, Yokoyama Kunihiko, Okuda Koichi, Edenbrandt Lars:Diagnostic accuracy of an artificial neural network compared with statistical quantitation of myocardial perfusion images: a Japanese multicenter study., European journal of nuclear
medicine and molecular imaging, 44:13;2280-2289, 2017.
8610B004 (Kenichi Nakajima), Koichi Okuda:123I-meta-iodobenzylguanidine Sympathetic Nerve Function Indices Derived
from Planar Images, Annals of Nuclear Cardiology, 3:1;200-202, 2017.
8610B005 Konishi Takahiro, Nakajima Kenichi, Okuda Koichi, Yoneyama Hiroto, Matsuo Shinro, Shibutani Takayuki, Onoguchi Masahisa, Kinuya Seigo:IQ-SPECT for thallium-201 myocardial perfusion imaging: effect of normal
databases on quantification., Annals of nuclear medicine, 31:6;454-461, 2017.
8610B006 Okuda Koichi, Nakajima Kenichi:Normal Values and Gender Differences of Left Ventricular Functional Parameters
with CardioREPO Software, Annals of Nuclear Cardiology, 3:1;29-33, 2017.
8610B007 Yoneyama Hiroto, Shibutani Takayuki, Konishi Takahiro, Mizutani Asuka, Hashimoto Ryosuke, Onoguchi Masahisa, Okuda Koichi, Matsuo Shinro, Nakajima Kenichi, Kinuya Seigo:Validation of the Left Ventricular Ejection Fraction with the IQ•SPECT System in Small-Heart Patients., Journal of nuclear medicine technology,
45:3;201-207, 2017.
8610B008 Okuda Koichi, Nakajima Kenichi, Matsuo Shinro, Kashiwaya Soichiro, Yoneyama Hiroto, Shibutani Takayuki, Onoguchi Masahisa, Hashimoto Mitsumasa, Kinuya Seigo:Comparison of diagnostic performance of four software packages for phase dyssynchrony analysis in gated myocardial perfusion SPECT, EJNMMI RESEARCH, 7:27, 2017.
8610B009 (Nakajima Kenichi), Okuda Koichi, Matsuo Shinro, Kiso Keisuke, Kinuya Seigo, Garcia Ernest V:Comparison of phase dyssynchrony analysis using gated myocardial perfusion imaging with four software programs: Based on the Japanese Society of Nuclear Medicine working group normal database, JOURNAL OF NUCLEAR CARDIOLOGY,
24:2;611-621, 2017.
8610B010 Yoneyama Hiroto, Nakajima Kenichi, Okuda Koichi, Matsuo Shinro, Onoguchi Masahisa, Kinuya Seigo, Edenbrandt Lars:Reducing the small-heart effect in pediatric gated myocardial perfusion single-photon emission computed
tomography, JOURNAL OF NUCLEAR CARDIOLOGY, 24:4;1378-1388, 2017.
8610B011 Yasuo Iida:Bounded Subsets of Classes Mp(X) of Holomorphic Functions, Journal of Function Spaces,
2017:7260602, 2017.
8610B012 (Nakajima Kenichi), Okuda Koichi, Yokoyama Kunihiko,Yoneyama Tatsuya, Tsuji Shiro, Oda Hiroyuki, Yoshita Mitsuhiro, Kubota Koji:Cross calibration of I-123-meta-iodobenzylguanidine heart-to-mediastinum ratio with D-
SPECT planogram and Anger camera, ANNALS OF NUCLEAR MEDICINE, 31:8;605-615, 2017.
8610B013 Yasuo Iida:Bounded Subsets of Smirnov and Privalov Classes on the Upper Half Plane, International Journal of
Analysis, 2017:9134768, 2017.
Short Communications 8610E001 (Nakajima Kenichi), Okuda Koichi;Verberne Hein J:Phase dyssynchrony and (123)I-meta-iodobenzylguanidine innervation imaging towards standardization., Journal of nuclear cardiology : official publication of the American
Society of Nuclear Cardiology, 1-5, 2017.
Presentations at Conference
International Conference (Presentations) 8610I001 Hideaki Shiga, Junichi Taki, Koichi Okuda, Naoto Watanabe, Hisao Tonami, Seigo Kinuya, Takaki Miwa: Correlation of thallium olfactory transport and olfactory bulb volume in patients with olfactory impairment after upper respiratory infection, AChemS 39th Annual Meeting 2017, Florida, 2017.04.
- 107 - 8620 Human Sciences
Faculty
Title Name Field of Specialization Professor SHIBUYA Yoshiho English linguistics, Phonetics Professor HARA Akira Austria literature led by Hofmannsthal Associate Professor HONDA Kojiro Ethics of technology Associate Professor KOCHI Munehiro Interpretationen von Goethes Werken, Begriff von Bildung Associate Professor TSUDA Ryosuke Exercise physiology, Pedagogy of physical education Philosophy, ethics, philosophy, ethics and the education, research of Senior Assistant Professor KIKUCHI Takeshi the thing supporting life, health, life, philosophy of the minority Senior Assistant Professor IKENAKA Masami English Education Senior Assistant Professor CRAIG Woods English, Medical English BURKE STEVEN Senior Assistant Professor English Thomas Assistant Professor MURAKAMI Yusuke adapted physical activity
Keywords of Research
exercise prescription, lifestyle-related diseases, improvement of physical fitness, soccer, PE class, , end of the century, culture, the middle Ages, Modern times, Europe, , articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 researchlanguage acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration, suffering, humanity cross-cultural differences, cultural variation, NLP, Python programming language, medical Englishe-learning, , logic, metaphysics, form, content, predicate, category, deduction, induction, matterbeing, substance, definion, Phenomenology, Philosophy of Technology, Ethics of Technology, Engineering Ethics, Robo-ethics, Medical Ethics, Cognitive Science of Learning, History of Science, Philosophy of Science,
Outline of Research
Hara:In the German-language area from the end of the 19th century to the beginning of the 20th century many prominent intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the German- language area and furthermore in all Europe many prominent intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He almost spent the entirety of his life in Vienna but his influence reaches the whole spiritual world of modern Europe. I analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the German-language area and furthermore in all Europe. Kouchi:Das Europa im zweiten Halfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen mittelalterlichnen Denkweise zur neuen modernen wie sie der Historiker Reinharｔ Kosellecｋ die ？Sattelzeit“ nennt. Wie man sich damals mit dem Wechsel des Paradigmas auseinander setzte mochte ich im Fall vom deutschen Dichter Goethe untersuchen und in seinen Werken wie Romanen und Dramen zeigen mochte ich im Fall vom deutschen Dichter Goethe untersuchen und in seinen Werken wie Romanen und Dramen zeigen HONDA:It is inquiring about the ethics of technology. Tradition of knowledge" has considered the problem what kind of responsibility occurs why in possible one and the side which inherits knowledge again by the mainly phenomenological technique. Shibuya:Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here Japanese) influence the pronunciation of
- 108 - Japanese speakers of English is studied, Japanese) influence the pronunciation of Japanese speakers of English is studied. Burke:My most recent research interest has been the connection and power that extensive reading has on English acquisition for EFL students. Woods:Using computer software for natural language processing of the English found in medical articles to determine the most commonly used words forms and structures. Ikenaka:My research topic is how to utilize e-learning materials effectively to raise the motivation of students. Tsuda:Our research includes prevention of lifestyle-related diseases for middle aged and elderly persons. In addition our research focuses on improvement of physical fitness through soccer in PE classes for children.
Publications
Originals
8620B001 Kojiro Honda:Neo-Luddism in the 21st century -AI will cause a new labor issue, 44:1-10, 2017.
Presentations at Conference
International Conference (Presentations) 8620I001 Ryosuke Tsuda:Results of a soccer teaching program intended to help students improve and acquire knowledge of
physical fitness, The 22nd annual Congress of the European College of Sport Science (ECSS), Essen, 2017.
- 109 -
University Hospital
0675 Health Evaluation Center
Faculty
Title Name Field of Specialization Professor ASAJI Takayoshi Heartfailure Professor(Additional Post) ISHIZAKI Masao Occupational health, Epidemiology for cardiovascular disease Professor(Additional Post) NISHIJO Muneko Environmental epidemiology, epidemiology of cadmium pollution Professor(Additional Post) MORIKAWA Yuko Cardiovascular epidemiology, occupational medicine Associate Professor NAKANISHI Yumiko Preventive medicine Associate Professor SAKURAI Masaru Cardiovascular epidemiology, preventive cardiology (Additional Post) Senior Assistant Professor NAGASAWA Shinya Cardiovascular epidemiology, preventive cardiology (Additional Post) Assistant Professor ISHIDA Ryoko Ischemic heart disease, Coronary intervention Assistant Professor KAWANAMI Haruka Hematology and Immunology
Keywords of Research
health examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking, alcohol intake, life style, stress, dietary habits, nutrient intake, exercise
Outline of Research
Studies for improvement of total medical check system and method of health support.
Publications
Originals 0675B001 (Keiko Kubo), Kazuhiro Nogawa, Teruhiko Kido, Nishijo Muneko, Hideaki Nakagawa, Yasushi Suwazono:Estimation of Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants of an Environmentally Exposed River Basin in Japan, Risk analysis : an official publication of the Society for Risk
Analysis, 37:1;20-26, 2017.
0675B002 (Koshi Nakamura), Masaru Sakurai, Yuko Morikawa, Shin-ya Nagasawa, Katsuyuki Miura, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Motoko Nakashikma, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Serum ferritin, insulin resistance, and β-cell dysfunction: a prospective study in normoglycemic Japanese men, Experimental and
clinical endocrinology & diabetes, 125:1;12-20, 2017.
0675B003 M.Sakurai, K.Yoshita, K.Nakamura, K.Miura, T.Takamura, S-Y.Nagasawa, Y.Morikawa, T.Kido, Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, M.Ishizaki, H.Nakagawa:Skipping breakfast and 5-year changes in body mass
index and waist circumference in Japanese men and women, Obesity Science & Practice, 3:2;162-170, 2017.
0675B004 (Amartuvshin Bor), Muneko Nishijo, Hiroshi Nishimaru, Tomoya Nakamura, Nghi Ngoc Tran, Quang Van Le, Yusaku Takamura, Jumpei Matsumoto, Yoshikazu Nishino, Hisao Nishijo:Effects of high fat diet and perinatal dioxin exposure on development of body size and expression of platelet-derived growth factor receptor beta in the rat
brain, Journal of Intergrative Neuroscience, 16:4;453-470, 2017.
0675B005 (Hirokazu Kakuda), Junji Kobayashi, Masaru Sakurai, Masahiro Kakuda, Noboru Takekoshi:The effect of tofogliflozin treatment on postprandial glucose and lipid metabolism in Japanese men with type 2 diabetes: A pilot
study, Journal of clinical medicine research, 9:5;403-409, 2017.
- 110 - 0675B006 (Rie Oka), Kyoko Shibata, Masaru Sakurai, Mitsuhiro Kometani, Masakazu Yamagishi, Kenichi Yoshimura, Takashi Yoneda:Trajectories of postload plasma glucose in the development of type 2 diabetes in Japanese adults, Journal
of Diabetes Research, 2017:5307523, 2017.
0675B007 (Toshinari Takamura), Yuki Kita, Masatoshi Nakagen, Masaru Sakurai, Yuki Isobe, Yumie Takeshita, Kohzo Kawai, Takeshi Urabe, Shuichi Kaneko:Weight-adjusted lean body mass and calf circumference are protective against
obesity-associated insulin resistance and metabolic abnormalities, Heliyon, 3:7;e00347, 2017.
0675B008 Muneko Nishijo, Kowit Nambunmee, Dhitiwass Suvagandha, Witaya Swaddiwudhipong, Werawan Ruangyuttikarn, Yoshikazu Nishino:Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand, International Journal of Envitronmental Research and Publich Health,
14:4;401, 2017.
0675B009 Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki, Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose, Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.
0675B010 Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Teruhiko Kido:Causes of death in patients with Itai-itai disease suffering from severe chronic cadmium poisoning: a nested case-control analysis of a
follow-up study in Japan, BMJ Open, 7:7;e015694, 2017.
0675B011 (Hirata Takumi), Sugiyama Daisuke, Nagasawa Shin-Ya, Murakami Yoshitaka, Saitoh Shigeyuki, Okayama Akira, Iso Hiroyasu, Irie Fujiko, Sairenchi Toshimi, Miyamoto Yoshihiro, Yamada Michiko, Ishikawa Shizukiyo, Miura Katsuyuki, Ueshima Hirotsugu, Okamura Tomonori:A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan., European journal of epidemiology,
32:547-557, 2017.
0675B012 (Kazuhiro Nogawa), Masaru Sakurai, Masao Ishizaki, Teruhiko Kido, Hideaki Nakagawa, Yasushi Suwazono: Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark
dose analysis, Journal of Applied Toxicology, 37:8;962-966, 2017.
0675B013 Takamura Taka-aki, Tsuchiya Taketsugu, Oda Minako, Watanabe Makoto, Saito Ryuhei, Sato-Ishida Ryoko, Akao Hironobu, Kawai Yasuyuki, Kitayama Michihiko, Kajinami Kouji:Circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) as a novel predictor of clinical outcome after endovascular therapy in patients with
peripheral artery disease (PAD), ATHEROSCLEROSIS, 263:192-197, 2017.
0675B014 K.Kawaura, T.Itoh, K.Hamada, H.Kitakata, S.Azukisawa, H.Okamura, S.Urashima, M.Sakurai, M.Ishizaki:Selection of Methods for Percutaneous Endoscopic Gastrostomy(PEG)that is more Safety and Useful Techniques on the
Patients., CLINICAL INVESTIGATION, 7:3;111-118, 2017.
0675B015 (Xian Liang Sun), Teruhiko Kido, Seijiro Honma, Eitetsu Koh, Rie Okamoto, Ho Dung Manh, Shoko Maruzeni, Muneko Nishijo, Hideaki Nakagawa, Takeshi Nakano, Takumi Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le Ke Son:The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in
Vietnamese men, Science of the Total Environment, 595:842-848, 2017.
0675B016 (Kishi Reiko), Zhang Jun Jim, Ha Eun-Hee, Chen Pau-Chung, Tian Ying, Xia Yankai, Tsuchiya Kenji J, Nakai Kunihiko, Kim Sungkyoon, Hong Soo-Jong, Hong Yun-Chul, Lee Jeong-Rim, Jan Mohamed Hamid Jan B, Parajuli Rajendra Prasad, Adair Linda S, Chong Yap Seng, Guo Yue Leon, Wang Shu-Li, Nishijo Muneko, Kido Teruhiko, Tai Pham The, Nandasena Sumal:Birth Cohort Consortium of Asia: Current and Future Perspectives, Epidemiology
(Cambridge, Mass.), 28:Suppl 1;19-34, 2017.
0675B017 Hirokazu Kakuda, Junji Kobayashi, Masaru Sakurai, Noboru Takekoshi:The Effects of Tofogliflozin on Glucose
Metabolism and Uric Acid, Progress in Medicine, 37:10;1219-1223, 2017.
- 111 - Reviews 0675C001 Yasufumi Masaki, Shino Fujimoto, Haruka Kawanami (Iwao), Tomoyuki Sakai, Takafumi Kawanami, Yopshimasa Fujita, Hiroshi Kawabata, Toshihiro Fukushima:The treatment strategy of IgG4-related disease - from the result of
prospective clinical study -, 29:2;140-146, 2017.
Presentations at Conference
International Conference (Presentations) 0675I001 Shinya Nagasawa, Katsuyuki Miura, Masaru Sakurai, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yasushi Suwazono, Kazuhiro Nogawa, Hideaki Nakagawa:Longitudinal association between body weight change and 6-year
change of blood pressure in Japanese men, EPI|LIFESTYLE2017, Portland, 2017.03.
0675I002 M.Nishijo, H.Nakagawa, K.Nogawa, T.Suwazono, T.Kido:Cancer mortality of residents living in the cadmium- polluted Jinzu River basin in Toyama,Japan, 14th International Conference on the Biogeochemistry of Trace
Elements, Zurich, 2017.07.
- 112 -
Medical Research Institute
7100 Department of Life Sciences
Faculty
Title Name Field of Specialization Professor ISHIGAKI Yasuhito Molecular and Cellular Biology Professor IWAWAKI Takao Cellular stress response Associate Professor OTA Takahide Molecular analysis of the mechanism of cancer metastasis Protein regulation by the post-translational modifications and its Associate Professor TASAKI Takafumi underlying molecular mechanisms Senior Assistant Professor OHTSUKA Satoshi Stem Cell Biology Senior Assistant Professor TANIGUCHI Makoto Molecular and Cellular Biology, Lipid Biochemistry Assistant Professor TATSUNO Takanori Molecular biology HIRAMATSU Assistant Professor Molecular and Cellular Biology Nobuhiko
Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, HCV, JEV, virus replication, RNAi, micro RNA, centrosome, polyploid cells, polyploidization, triploid/tetraploid/octaploid cells, Meth-A cells, V79 cells, H-1(ES) cells, RhoGDI, Rho family, epitherial/mesenchymal, transfection, RNA surveillance, nonsense mediated mRNA decay, mutation, DNA microarray, transcriptome, proteome, apoptosis, ultra micro structure, mouse germ cells, DNA repair, fibroblast growth factor, tumor growth angiogenesis, Ubiquitin-proteasome system, Autophagy, protein quality control, gene expression control, homeostatic regulation, biological defense system, molecular imaging
Outline of Research
1.Study on viral replication and pathogenicity 2.Molecular mechanism of carcinogenesis and metastasis 3.Research on plolyploidization and polyploid cells 4.Analyses of transcription and mRNA decay 5.Protein regulation by the post-translational modifications and its underlying molecular mechanisms 6.Lipid metabolism and its-associated diseases 7.Stem cell biology and development 8.Physiologocal and pathological function of cellular stress response
Publications
Originals 7100B001 (Kotaro Higashi), Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki , Yuka Nakamura, Managu Oguchi, Tsutomu Takegami, Naoto Watanabe:High FDG uptake on PET is associated with negative cell-to-cell adhesion
molecule E-cadherin expression in lung adenocarcinoma, Annals of nuclear medicine, 31:590-595, 2017.
7100B002 (Souichi Nukuzuma), Chiyoko Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Takafumi Tasaki, Tsutomu Takegami:CPT11 prevents virus replication in JCI cells persistently infected with JC polyomavirus.,
Microbiology and immunology, 61:6;232, 2017.
- 113 - 7100B003 (Tschurtschenthaler M), Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A:Defective ATG16L1-mediated removal
of IRE1α drives Crohn's disease-like ileitis, The Journal of Experimental Medicine, 214:2;401-422, 2017.
7100B004 (Duran-Aniotz C), Cornejo VH, Espinoza S, Ardiles ÁO, Medinas DB, Salazar C, Foley A, Gajardo I, Thielen P, Iwawaki T, Scheper W, Soto C, Palacios AG, Hoozemans JJM, Hetz C:IRE1 signaling exacerbates Alzheimer's
disease pathogenesis, Acta Neuropathologica, 134:489-506, 2017.
7100B005 (Fink SL), Jayewickreme TR, Molony RD, Iwawaki T, Landis CS, Lindenbach BD, Iwasaki A:IRE1α promotes viral
infection by conferring resistance to apoptosis, Science Signaling, 10:eaai7814, 2017.
7100B006 (Márquez S), Fernández JJ, Terán-Cabanillas E, Herrero C, Alonso S, Azogil A, Montero O, Iwawaki T, Cubillos- Ruiz JR, Fernández N, Crespo MS:Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by
Human Dendritic Cells, Frontiers in Immunology, 8:639, 2017.
7100B007 (Hiraoka H), Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N, Uehara T:Modulation of Unfolded Protein Response by Methylmercury, Biological and Pharmaceutical Bulletin,
40:1595-1598, 2017.
7100B008 (Oh S), Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T, Yamamoto M, Shoda J:Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity
via redox modulation in skeletal muscles, Scientific Reports, 7:12902, 2017.
7100B009 (Motegi SI), Sekiguchi A, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O:Protective effect of mesenchymal stem cells on the pressure ulcer
formation by the regulation of oxidative and endoplasmic reticulum stress, Scientific Reports, 7:17186, 2017.
7100B010 (Forootan SS), Mutter FE, Kipar A, Iwawaki T, Francis B, Goldring CE, Park BK, Copple IM:Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity,
Scientific Reports, 7:16084, 2017.
7100B011 (Tavernier SJ), Osorio F, Vandersarren L, Vetters J, Vanlangenakker N, Van Isterdael G, Vergote K, De Rycke R, Parthoens E, van de Laar L, Iwawaki T, Del Valle JR, Hu CA, Lambrecht BN, Janssens S:Regulated IRE1-
dependent mRNA decay sets the threshold for dendritic cell survival, Nature Cell Biology, 19:698-710, 2017.
7100B012 Iwawaki T, Akai R, Toyoshima T, Takeda N, Ishikawa T, Yamamura K:Transgenic mouse model for imaging of
ATF4 translational activation-related cellular stress responses in vivo, Scientific Reports, 7:46230, 2017.
7100B013 Y.Yoshitomi, T.Ikeda, H.Saito, Y.Yoshitake, Y.Ishigaki, T.Hatta, N.Kato, H.Yonekura:JunB regulates angiogenesis
and neurovascular parallel alignment in mouse embryonic skin, Jonal of Cell Science, 130:5;916-926, 2017.
7100B014 (Kaufman DR), Papillon J, Larose L, Iwawaki T, Cybulsky AV:Deletion of Inositol-Requiring Enzyme-1α in Podocytes Disrupts Glomerular Capillary Integrity and Autophagy, Molecular Biology of the Cell, 28:12;1636-
1651, 2017.
7100B015 Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata, Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.
7100B016 Toshio Ohnishi, Chieko Hashizume, Makoto Taniguchi, Hidehiro Furumoto, Jia Han, Rongfen Gao, Shinichi Kinami, Takeo Kosaka, Toshiro Okazaki:Sphingomyelin synthase 2 deficiency inhibits the induction of murine
colitis-associated colon cancer, The Faseb Journal, 31:9;3816-3830, 2017.
7100B017 Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation of
multiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.
Reviews 7100C001 Takao Iwawaki:Transgenic mouse models for molecular optical imaging in vivo, The Journal of Japan Society for
Laser Surgery and Medicine, 37:454-458, 2017.
7100C002 Takao Iwawaki:From property of IL-1β to imaging of inflammation, Japanese Journal of Clinical Immunology,
40:329-336, 2017.
- 114 - Presentations at Conference
International Conference (Key Note Lecture) 7100G001 Toshiro Okazaki, Chieko Hashizume, Makoto Taniguchi, Takeo Kosaka:Role of sphingomyeline synthase 2 (SMS2) in murine colitis and colon cancer, 3rd International Conference on New Horizons of Basic nd Applied Science,
Hurghada, 2017.08.
7100G002 Takafumi Tasaki:Molecular mechanism of the interaction between UBR4 and HPVE7, N-Term 2017, Halle,
2017.09.
International Conference (Presentations) 7100I001 Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P. Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.05.
7100I002 (Yukihisa Suzuki), Masami Kojima, Maya Mizuno,Tsutomu Okuno, Masao Taki, J Chakarothai, Kensuke Sasaki, Kanako Wake, Souichi Watanabe, Hiroshi Sasaki:Estimation of the thresholds for corneal epithelium damage induced by millimeter-wave electromagnetic field exposure with a mathematical model based on CEM43℃
criterion, 32nd URSI GASS, Montreal, 2017.08.
7100I003 (Saioa Márquez), José Javier Fernández, Eli Terán-Cabanillas, Carmen Herrero, Takao Iwawaki, Juan R Cubillos- Ruiz, Nieves Fernández, Mariano Sánchez Crespo:Endoplasmic reticulum stress sensor IRE1α and PERK enhance IL-23 expression by human dendritic cell, The 31st Annual Meeting of the European Macrophage and Dendritic
Cell Society, Madrid, 2017.09.
7100I004 Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki:CREATING A SHORT- TERM STABLE ENVIRONMENT FOR RABBITS IN A CARGO VAN, 68th AALAS National Meeting, Austin,
2017.10.
7100I005 Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi Sasaki, Eri Kubo:Konck-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.12.
- 115 - 7200 Department of Advanced Medicine
Faculty
Title Name Field of Specialization Professor TAKEUCHI Masayoshi AGEs, Lifestyle-related disease Professor TOMOSUGI Naohisa Clinical Proteomics Professor(Additional Post) OKAZAKI Toshiro Hematology and Immunology, Hematology/Oncology Professor(Additional Post) MOTOO Yoshiharu Clinical Oncology, Gastroenterology, Cancer Cell Biology Associate Professor SHIMASAKI Takeo Medical Oncology, Gastroenterology, BioInformatics Associate Professor NIIDA Yo Genetic disease, Genetic diagnosis Senior Assistant Professor OZAKI Mamoru cytogenetics, Molecular cytogenetics Assistant Professor TAKATA Takanobu AGEs, Biochemistry Assistant Professor SAKASAI Akiko AGEs, Cell Biology
Keywords of Research
renal cell carcinoma, cytogenetics, metalloproteinase, mesangial cell, renal disease, chronic renal failure, glomerulonephritis, anti-aging, AGEs, heart failure, cardiomyopathy, nerohumoral factor, autoantibody, cell cycle, epigenetics, clinical oncology, gastroenterology, tumor biology, genetic counseling, genetic service, prenatal diagnosis, congenital abnormality, karyotype,
Outline of Research
1.Heart failure by autoimmune pathway related with G-protein 2.Study on hepcidin-25 as iron regulatory factor in the hemodialysis patient 3.The role of Toxic AGEs(TAGE) in the prevention of lifestyle related disease 4.Clinical research for the diagnosis and treatment of pancreatic cancer 5.Development and clinical application of fetal DNA diagnosis using mother’s blood 6.Genetic diagnosis and analysis of hereditary developmental disability 7.Development of molecular method to detect the abnormality of chromosome, and risk evaluation about balance type of reciprocal translocation
Publications
Originals 7200B001 Ippei Chikazawa, Shinya Inoue, Yusuke Nakazawa, Dan Nakai, Nobuyo Morita, Tatsuro Tanaka, Yoshiharu Motoo, Katsuhito Miyazawa:Clinical study on the efficacy and continuous docetaxel based chemotherapy treatment for
castration-resistant prostate cancer, 63:9;351-357, 2017.
7200B002 S.Sakamoto, H.Kawabata, J.Kanda, T.Uchiyama, C.Mizumoto, T.Kitano, T.Kondo, M.Hishizawa, N.Tomosugi, A.Takaori-Kondo:High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet
engraftment after allogeneic hematopoietic stem cell transplantation., Cancer medicine, 6:1;120-128, 2017.
7200B003 Keiko Yukawa, Hirono Ishikawa, Yoshihiko Yamazaki, Jimpei Misawa, Kiichiro Tsutani, Ichiro Arai, Yoshiharu Motoo, Takahiro Kiuchi:Economic burden and mental distress in using complementary and alternative medicine, and formal supports by medical professional of japanese patients with chronic diseases, Japanese Pharmacology &
Therapeutics, 45:3;345-355, 2017.
- 116 - 7200B004 M.Watanabe, Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi, T.Tsuchiya, H.Nakanishi, K.Saito, M.Takeuchi, K.Kajinami:Diurnal glycemic fluctuation is associated with severity of coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived
advanced glycation end products., Journal of cardiology, 69:4;625-631, 2017.
7200B005 Y Motoo, T Hakamatsuka, N Kawahara, I AraiI, K Tsutani:Standards of reporting Kampo products (STORK) in
research articles, Journal of Integrative Medicine, 15:3;182-185, 2017.
7200B006 (Jun-ichi Takino), Kentaro Nagamine, Mikoto Suzuki, Akiko Sakasai-Sakai, Masayoshi Takeuchi, Takamitsu Hori:Gene Expression Changes Associated with the Loss of Heterogeneous Nuclear Ribonucleoprotein M Function,
American Journal of Molecular Biology, 7:87-98, 2017.
7200B007 (Tahara Atsuko), Tahara Nobuhiro, Yamagishi Sho-ichi, Honda Akihiro, Igata Sachiyo, Nitta Yoshikazu, Bekki Munehisa, Nakamura Tomohisa, Sugiyama Yoichi, Sun Jiahui, Takeuchi Masayoshi, Shimizu Makiko, Yamazaki Hiroshi, Fukami Kei, Fukumoto Yoshihiro:Ratio of serum levels of AGEs to soluble RAGE is correlated with trimethylamine-N-oxide in non-diabetic subjects, INTERNATIONAL JOURNAL OF FOOD SCIENCES AND
NUTRITION, 68:8;1013-1020, 2017.
7200B008 Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata, Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.
7200B00 (Sannohe Takahiro), Ohnuma Tohru, Takeuchi Masayoshi, Tani Eriko, Miki Yasue, Takeda Mayu, Katsuta Narimasa, Takebayashi Yuto, Nakamura Toru, Nishimon Shohei, Kimoto Ayako, Higashiyama Ryoko, Shibata Nobuto, Gohda Tomohito, Suzuki Yusuke, Yamagishi Sho-Ichi, Tomino Yasuhiko, Arai Heii:High doses of antipsychotic polypharmacy are related to an increase in serum levels of pentosidine in patients with
schizophrenia., Progress in Neuro-Psychopharmacology & Biological Psychiatry, 76:42-48, 2017.
7200B010 Takanobu Takata, Tadashi Ueda, Akiko Sakasai-Sakai, Masayoshi Takeuchi:Generation of glyceraldehyde-derived advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion, World Journal of
Gastroenterology, 23:4910-4919, 2017.
7200B011 Bo Ryosuke, Yamada Kenji, Kobayashi Hironori, Jamiyan Purevsuren, Hasegawa Yuki, Taketani Takeshi, Fukuda Seiji, Hata Ikue, Niida Yo, Shigematsu Yosuke, Iijima Kazumoto, Yamaguchi Seiji:Clinical and molecular investigation of 14 Japanese patients with complete TFP deficiency: a comparison with Caucasian cases, JOURNAL
OF HUMAN GENETICS, 62:9;809-814, 2017.
7200B012 (Suzuki Toshiaki), Yamamoto Ayano, Ohsawa Masahiro, Motoo Yoshiharu, Mizukami Hajime, Makino Toshiaki: Effect of ninjin'yoeito and ginseng extracts on oxaliplatin-induced neuropathies in mice, Journal of Natural
Medicines, 71:4;757-764, 2017.
7200B013 Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Masayoshi Takeuchi:Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death, Scientific Reports,
7:14282, 2017.
7200B014 Yuko Matsui, Ryoko Murayama, Hidenori Tanabe, Makoto Oe, Yoshiharu Motoo, Takanori Wagatsuma, Michiko Michibuchi, Sachiko Kinosita, Keiko Sakai, Chizuko Konya, Junko Sugama, Hiromi Sanada:Evaluation of the predictive validity of thermography in identifying extravasation with intravenous chemotherapy infusions, Journal of
Infusion Nursing, 40:6;367-374, 2017.
7200B015 (Hori Eisei), Kikuchi Chigusa, Nagami Chie, Kajikuri Junko, Itoh Takeo, Takeuchi Masayoshi, Matsunaga Tamihide: Role of Glyceraldehyde-Derived AGEs and Mitochondria in Superoxide Production in Femoral Artery of OLETF
Rat and Effects of Pravastatin, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40:11;1903-1908, 2017.
7200B016 Toshio Ohnishi, Chieko Hashizume, Makoto Taniguchi, Hidehiro Furumoto, Jia Han, Rongfen Gao, Shinichi Kinami, Takeo Kosaka, Toshiro Okazaki:Sphingomyelin synthase 2 deficiency inhibits the induction of murine
colitis-associated colon cancer, The Faseb Journal, 31:9;3816-3830, 2017.
7200B017 (Kita Kenji), Arai Sachiko, Nishiyama Akihiro, Taniguchi Hirokazu, Fukuda Koji, Wang Rong, Yamada Tadaaki, Takeuchi Shinji, Tange Shoichiro, Tajima Atsushi, Nakada Mitsutoshi, Yasumoto Kazuo, Motoo Yoshiharu, Murakami Takashi, Yano Seiji:In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of
targeted drugs, Cancer Medicine, 6:12;2972-2983, 2017.
- 117 - 7200B018 Arisawa Tomiyasu, Nakamura Masakatsu, Otsuka Toshimi, Jing Wu, Sakurai Naoko, Takano Hikaru, Hayashi Tasuku, Ota Masafumi, Nomura Tomoe, Hayashi Ranji, Shimasaki Takeo, Tahara Tomomitsu, Shibata Tomoyuki: Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative
colitis in Japan, WORLD JOURNAL OF GASTROENTEROLOGY, 23:29;5364-5370, 2017.
Reviews 7200C001 Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata:Involvement of toxic AGEs(TAGE) in the onset /
progrssion of nonalcoholic fatty liver disease (NAFLD): A novel prevention strategy, 23:20-30, 2017.
7200C002 Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi:Toxic AGE
(TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD, Nutrients, 9:634-, 2017.
7200C004 Yoshiharu Motoo:Gastrointestinal adverse effects and their management in molecular targeting therapy, Nippon
Rinsho, 75:9;1425-1429, 2017.
Case Reports 7200D001 Y.Yasui, M.Kohno, S.Nishida, T.Shironomae, M.Satomi, T.Kuwahara, S.Takahashi, Y.Niida:Cartilage-hair hypoplasia associated with isolated hypoganglionosis: A case report, CONGENITAL ANOMALIES, 57:1;32-34,
2017.
7200D002 Niida Yo, Mitani Yusuke, Kuroda Mondo, Yokoi Ayano, Nakagawa Hiroyasu, Kato Akiko:A Say-Barber-Biesecker- Young-Simpson variant of Ohdo syndrome with a KAT6B 10-base pair palindromic duplication: A recurrent mutation causing a severe phenotype mixed with genitopatellar syndrome, CONGENITAL ANOMALIES, 57:3;86-
88, 2017.
7200D003 Nobuhiko Ueda, Yoritaka Fujii, Seiko Miura, Jun Fujita, Yasuto Tomita, Toshio Ohnishi, Hideto Fujita, Shinichi Kinami, Kazuhiko Omote, Yasuharu Nakano, Takeo Kosaka, Yoshiharu Motoo:Long-term survival due to combination therapy in a patient with locally advanced body-tall pancreatic cancer, Japanese Journal of Cancer and
Chemotherapy, 44:12;1373-1375, 2017.
Short Communications 7200E001 Niida Yo, Yokoi Ayano, Kuroda Mondo, Mitani Yusuke, Nakagawa Hiroyasu, Ozaki Mamoru:Reply to: Uniparental disomy of chromosome 1 unmasks recessive mutations of PPT1 in a boy with neuronal ceroid lipofuscinosis type 1,
BRAIN & DEVELOPMENT, 39:2;184-185, 2017.
7200E002 (Yokota Mami), Sekita Marie, Okano Yuri, Masaki Hitoshi, Takeuchi Masayoshi, Tokudome Yoshihiro: Glyceraldehyde-Derived Advanced Glycation End Products Accumulate Faster Than N-epsilon-(Carboxymethyl) Lysine, ANNALS OF DERMATOLOGY, 29:4;508-511, 2017.
Presentations at Conference
International Conference (Key Note Lecture) 7200G001 Toshiro Okazaki:Inhibition of acute colitis and hepatic infiltration malignant cells by SMS2 deficiency, Key note
speaker at 8th international Ceramide Conference, New York, 2017.05.
7200G002 Toshiro Okazaki, Chieko Hashizume, Makoto Taniguchi, Takeo Kosaka:Role of sphingomyeline synthase 2 (SMS2) in murine colitis and colon cancer, 3rd International Conference on New Horizons of Basic nd Applied Science,
Hurghada, 2017.08.
7200G003 Toshiro Okazaki:Ceramid increase by deficiency of sphingomyelin synthase (SMS) 2 suppressed murine acute colitis and colon cancer initiation through cytokine/chemokine inhibition, Bioactive Lipids in Cancer,Inflammation
&Related Diseases, 15th international conference, Puerto Vallarta, Mexico, 2017.10.
International Conference (Symposium) 7200H001 Y Motoo:Standards of Reporting Kampo Products (STORK) in research articles., The 4th International Symposium
of Japanese Kampo Medicine (ISJKM), Berlin, 2017.05.
7200H002 Y Motoo:Chemotherapy Support Team (CST) and Kampo, 12th International Congress of Complementary Medicine
and Research (ICCMR), Berlin, 2017.05.
- 118 - International Conference (Presentations) 7200I001 Yo Niida, Mamoru Ozaki:Mutational Analysis of TSC1 and TSC2 in Japanese Patients with Tuberous Sclerosis
Complex, 14th Asian and Oceanian Congress of Child Neurology, Fukuoka, 2017.05.
7200I002 Tomiyasu Arisawa, Hikaru Takano, Tasuku Hayashi, Wu Jing, Masafumi Ota, Tomoe Nomura, Ranji Hayashi, Toshimi Otsuka, Takeo Shimasaki, Masakatsu Nakamura:THE PRE-MICRORNA938,TARGETING 1L-17L 3'- UTR,GENE POLYMORPHISMS IS ASSOCIATED WITH THE RISK FOR DAP-KINASE HYPERMETHYLATION
IN HP INFECTED JAPANESE SUBJECTS, DDW2017, Chicago, 2017.05.
7200I003 Hitoshi Sato, Atsushi Ishii, Chisato Akita, Kanju Ikeno, Yo Niida, Sawako Yamazaki, Shinichi Hirose, Hiroaki Kakinuma, Yutaka Saikawa:A case with severe recurrent attacks of hemiplegic migraine mimicking acute
encephalopathy, 14th Asian and Oceanian Congress of Child Neurology, Fukuoka, 2017.05.
- 119 - 7310 Division of Innovative Research
Faculty
Title Name Field of Specialization Professor(Additional Post) YONEKURA Hideto Molecular mechanisms of angiogenesis, Alternative mRNA processing Environmental epidemiology, Enviromental health sciences, Professor(Additional Post) NISHIJO Muneko Epidemiology of cadmium pollution
Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants, neurovirology, Cancer chemoprevention by natural products,
Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants. 2. Cellular and molecular mechanisms in angiogenesis
Publications
Originals 7310B001 (Keiko Kubo), Kazuhiro Nogawa, Teruhiko Kido, Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono:Estimation of Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants of an Environmentally Exposed River Basin in Japan, Risk analysis : an official publication of the Society for Risk
Analysis, 37:1;20-26, 2017.
7310B002 (Amartuvshin Bor), Muneko Nishijo, Hiroshi Nishimaru, Tomoya Nakamura, Nghi Ngoc Tran, Quang Van Le, Yusaku Takamura, Jumpei Matsumoto, Yoshikazu Nishino, Hisao Nishijo:Effects of high fat diet and perinatal dioxin exposure on development of body size and expression of platelet-derived growth factor receptor beta in the rat
brain, Journal of Intergrative Neuroscience, 16:4;453-470, 2017.
7310B003 Y.Yoshitomi, T.Ikeda, H.Saito, Y.Yoshitake, Y.Ishigaki, T.Hatta, N.Kato, H.Yonekura:JunB regulates angiogenesis
and neurovascular parallel alignment in mouse embryonic skin, Journal of Cell Science, 130:5;916-926, 2017.
7310B004 Muneko Nishijo, Kowit Nambunmee, Dhitiwass Suvagandha, Witaya Swaddiwudhipong, Werawan Ruangyuttikarn, Yoshikazu Nishino: Gender-specific impact of cadmium exposure on bone metabolism in older people living in a cadmium-polluted area in Thailand, International Journal of Envitronmental Research and Publich Health, 14:4;401,
2017.
7310B005 Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata, Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.
7310B006 Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Teruhiko Kido:Causes of death in patients with Itai-itai disease suffering from severe chronic cadmium poisoning: a nested case-control analysis of a
follow-up study in Japan, BMJ Open, 7:7;e015694, 2017.
7310B007 (Xian Liang Sun), Teruhiko Kido, Seijiro Honma, Eitetsu Koh, Rie Okamoto, Ho Dung Manh, Shoko Maruzeni, Muneko Nishijo, Hideaki Nakagawa, Takeshi Nakano, Takumi Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le Ke Son:The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in
Vietnamese men, Science of the Total Environment, 595:842-848, 2017.
- 120 - 7310B008 (Kishi Reiko), Zhang Jun Jim, Ha Eun-Hee, Chen Pau-Chung, Tian Ying, Xia Yankai, Tsuchiya Kenji J, Nakai Kunihiko, Kim Sungkyoon, Hong Soo-Jong, Hong Yun-Chul, Lee Jeong-Rim, Jan Mohamed Hamid Jan B, Parajuli Rajendra Prasad, Adair Linda S, Chong Yap Seng, Guo Yue Leon, Wang Shu-Li, Muneko Nishijo, Kido Teruhiko, Tai Pham-The, Nandasena Sumal:Birth Cohort Consortium of Asia: Current and Future Perspectives,
Epidemiology (Cambridge, Mass.), 28:Suppl 1;19-34, 2017.
Presentations at Conference
International Conference (Presentations) 7310I001 Muneko Nishijo, Hideaki Nakagawa, Kazuhiro Nogawa, Yasushi, Suwazono, Teruhiko Kido:Cancer mortality of residents living in the cadmium-polluted Jinzu River basin in Toyama,Japan, 14th International Conference on the
Biogeochemistry of Trace Elements, Zurich, 2017.07.
- 121 - 7320 Division of Vision Research for Environmental Health
Faculty
Title Name Field of Specialization Professor(Additional Post) SASAKI Hiroshi cataract, epidemiology, uveitis cataract, ophthalmological optics, electromagnetic ocular injury, Professor(Additional Post) KOJIMA Masami epidemiolgy Associate Professor FUKUDA Masamichi ocular pharmacology, intraocular, penetration (Additional Post) Assistant Professor HATSUSAKA Natsuko ophthalmological optics (Additional Post)
Keywords of Research
electromagnetic waves, ultraviolet rays, radioactive rays, cataract, pterygium, pinguecula.
Outline of Research
This research division studies environmental effects on incidence of ocular diseases. In quantitative studies of radio frequency (RF) electromagnetic spectrum effects on eyes, ocular effects from exposure to wavelengths encountered in daily life are examined by experimentation on rabbit eyes. Research on ocular exposure to ultraviolet (UV) wavelengths utilizes a human like mannequin equipped with UV sensors, and evaluates the efficacy of sunglasses, eye glasses and other accessories in offering eye protection against harmful exposure. Our longitudinal epidemiological studies on eyes in Japan (Ishikawa) and Iceland, epidemiological surveys on blindness and UV-related eye disease in Tanzania, and ocular epidemiological studies in domestic and international regions with different climate conditions were conducted to investigate and analyze associations among ocular UV exposure and cataract, pterygium, and pinguecula. In our epidemiological study on UV-related ocular diseases targeting Japanese and Taiwanese children, the effects of ocular UV exposure in childhood are examined. In 2013, a longitudinal study on radiation exposure dose and incidence of lens opacity in emergency workers of TEPCO Fukushima Daiichi Nuclear Power Plant was commenced and is envisaged to include approximately 20,000 subjects.
Publications
Originals 7320B001 (Noriaki Nagai), Yu Mano, Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:Amyloid β1-43 Accumulates in the Lens Epithelium of Cortical Opacification in Japanese Patients, Investigative Ophthalmology & Visual Science,
58:3294-3302, 2017.
7320B002 Hiroshi Sasaki:Primary and secondary preventions of cataracts, Rinsho Ganka, 71:1;52-60, 2017.
7320B003 (Noriaki Nagai), Yoshimasa Ito, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:A positive feedback loop between nitric oxide and amyloid β(1-42) accelerates mitochondrial damage in human lens epithelial cells, Toxicology, 381:19-
30, 2017.
7320B004 E.Kubo, S.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, Dhirendra P.Singh:FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity., Journal of Cellular and Molecular Medicine,
21:5;916-928, 2017.
7320B005 (Koji Kitazawa), Chie Sotozono, Noriko Koizumi, Kenji Nagata, Tsutomu Inatomi, Hiroshi Sasaki, Shigeru Kinoshita:Safety of anterior chamber paracentesis using a 30-gauge needle integrated with a specially designed
disposable pipette, British Journal Of Ophthalmology, 101:548-550, 2017.
- 122 - 7320B006 (Norihiro Mita), Hiroshi Sasaki, Kazutaka Kani, Akio Tabuchi, Heihachiro Hara:Multiple comparisons in two-factor testing of psychophysical thresholds by the delta test method, Communications in statistics-simulation and
computation, 46:1;669-678, 2017.
7320B007 Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P. Singh:Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, Scientific reports,
7:14130, 2017.
7320B008 (Toshiyuki Hayashida), Hiroshi Sasaki, Nobuyuki Hamada, Hideo Tatsuzaki, Natsuko Hatsusaka, Keiichi Akahane, Sumi Yokoyama:Issues behind Radiation Management of Workers at Fukushima Nuclear Power Plant of Tokyo Electric Power Company -From the Viewpoint of Radiation Exposure of the Ocular Lens and the Biological Effects
to the Lens-, Japanese Journal of Health Physics, 52:2;88-99, 2017.
Case Reports 7320D001 Nobuyuki Fujita, Teppei Shibata, Masamichi Fukuda, Kazuyuki Sasaki, Hiroshi Sasaki:An ease with successful treatment of the endogenous endophthalmitis caused by Streptococcus anginosus endocarditis, Folia Japanica de
Ophthalmologica Clinica, 10:12;1007-1010, 2017.
Presentations at Conference
International Conference (Symposium) 7320H001 Masami Kojima:Acute ocular injuries caused by 40, 75, 95 GHz millimeter wave exposure, BioEM, Hangzhou,
2017.
International Conference (Presentations) 7320I001 Hiroshi Sasaki, Natsuko Hatsusaka, Hisanori Miyashita, Naoko Shibata, Yusuke Seki, Teppei Shibata, Hiromi Osada, Hidetoshi Ishida, Masami Kojima Eri Kubo:Crystalline lens change peculiar to diabetes, The Association for
Research in Vision and Ophthalmology, Baltimore, 2017.
7320I002 Hisanori Miyashita, Natsuko Hatsusaka, Yusuke Seki, Aya Nakano, Masami Kojima, Yutaka Kawakami, Eri Kubo, Hiroshi Sasaki:Influence of ocular UV exposure on risk of cataract in Chinese, The Association for Research in
Vision and Ophthalmology, Baltimore, 2017.
7320I003 Eri Kubo, Shinsuke Shibata, Teppei Shibata, Naoki Tanimura, Dhirendra P. Singh, Hiroshi Sasaki:FGF2-mediated induction of microRNA29c and its regulation of Tropomyosin, The Association for Research in Vision and
Ophthalmology, Baltimore, 2017.
7320I004 Shinsuke Shibata, Naoko Shibata, Teppei Shibata, Naoki Tanimura, Hiroshi Sasaki, Eri Kubo:Effects of proteoglycan decorin on lens epithelial cells, The Association for Research in Vision and Ophthalmology,
Baltimore, 2017.
7320I005 Naoko Shibata, Shinsuke Shibata, Teppei Shibata, Etsuko Kiyokawa, Hiroshi Sasaki, Eri Kubo:Comparison of gene expression profiles in human pterygium and UV-induced gene expressions in human conjunctival epithelium, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.
7320I006 Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P. Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.
7320I007 Hidetoshi Ishida, Norihiro Mita, Eri Kubo, Mai Kita, Aya Nakano, Yuuki Ukai, Ayako Okamoto, Naoko Shibata, Eri Kubo, Hiroshi Sasaki:Comparison of the postoperative stability of the three types of single-piece intraocular
lenses, The Association for Research in Vision and Ophthalmology, Baltimore, 2017.
7320I008 Eri Shibuya, Mai Sasaki, Norihiro Mita, Ayako Okamoto, Mai Kita, Hiromi Osada, Naoko Shibata, Yoriko Takahashi, Eri Kubo, Hiroshi Sasaki:Posterior capsular wrinkle in eyes with 2 types of 1-piece intraocular lens,
The Association for Research in Vision and Ophthalmology, Baltimore, 2017.
7320I009 (Bhavana Chhunchha), Eri Kubo, Hiroshi Sasaki, Dhirendra P. Singh:Switching of redox signaling by sulforaphane determines lens epithelial cells fate by hormetic mechanisms involving Prdx6/Nrf2 and Klf9 pathways, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.
- 123 - 7320I010 (Yukihisa Suzuki), Masami Kojima, Maya Mizuno,Tsutomu Okuno, Masao Taki, J. Chakarothai, Kensuke Sasaki, Kanako Wake, Souichi Watanabe, Hiroshi Sasaki:Estimation of the thresholds for corneal epithelium damage induced by millimeter-wave electromagnetic field exposure with a mathematical model based on CEM43℃
criterion, 32nd URSI GASS, Montreal, 2017.
7320I011 Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki:CREATING A SHORT- TERM STABLE ENVIRONMENT FOR RABBITS IN A CARGO VAN, 68th AALAS National Meeting, Austin,
2017.10.
7320I012 Hiroshi Sasaki, Ayako Okamoto, Naoko Shibata, Eri Shibuya, Norihiro Mita, Hidetoshi Ishida, Eri Kubo:Influence on toric intraocular lems axis by incision misalignment:a simulation study, European Society of Cataract &
Refractive Surgens, Lisbon, 2017.
7320I013 Masami Kojima, Yukihisa Suzuki, Kensuke Sasaki, Hiroshi Sasaki:Microwave radiation cataract, International
Conference on the Lens, Kona, 2017.
7320I014 Hisanori Miyashita, Natsuko Hatsusaka, Hiromi Osada, Teppei Shibata, Yusuke Seki, Yutaka Kawakami, Masami Kojima, Eri Kubo, Hiroshi Sasaki:Risk of five types of cataract in eyes with pseudoexfoliation syndrome,
International Conference on the Lens, Kona, 2017.
7320I015 Shinsuke Shibata, Naoko Shibata, Teppei Shibata, Hiroshi Sasaki, Eri Kubo:Expression of decorin, and its relation
to posterior capsular opacification, International Conference on the Lens, kona, 2017.
7320I016 Natsuko Hatsusaka, Hisanori Miyashita, Naoki Tanimura, Yoshikazu Nishino, Eri Kubo, Hiroshi Sasaki:Ocular UV
exposure and cataract risk in highly myopic eyes, International Conference on the Lens, Kona, 2017.
7320I017 Norihiro Mita, Aya Nakano, Yuuki Ukai, Ayako Takayama, Eri Shibuya, Mai Kita, Hiromi Osada, Hisanori Miyashita, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:Anayusis of transparent lens formation in mid-and old-age by
anterior segment OCT, International Conference on the Lens, Kona, 2017.
7320I018 Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P Singh:Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, International
Conference on the Lens, Kona, 2017.
7320I019 Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi Sasaki, Eri Kubo:Konck-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.
- 124 - 7340 Division of Anticipatory Molecular Food Science and Technology
Faculty
Title Name Field of Specialization Professor(Additional Post) KOYA Daisuke diabetes, hypertension, obesity, aging Associate Professor KANASAKI Keizo diabetes, hypertenstion, obesity, preeclampsia (Additional Post) Associate Professor KITADA Munehiro diabetes, diabetical renal disease, hypertension (Additional Post)
Books
7340A001 Daisuke Koya:Capter3 Patient assessment and diagnosis, Managing diabetic nephropathies in clinical practice, 47-
56, Adis, Cham, 2017.
Publications
Originals 7340B001 (Yasuhiro Onogi), Tsutomu Wada, Chie Kamiya, Kento Inata, Takatoshi Matsuzawa, Yuka Inaba, Kumi Kimura, Hiroshi Inoue, Seiji Yamamoto, Yoko Ishii, Daisuke Koya, Hiroshi Tsuneki, Masakiyo Sasahara, Toshiyasu Sasaoka: PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced
Obesity., Diabetes, 66:4;1008-1021, 2017.
7340B002 (Shigehiro Katayama), Daishiro Yamada, Mikihiro Nakayama, Takashi Yamada, Masafumi Myoishi, Masaharu Kato, Christina Nowack, Peter Kolkhof, Yoshimitsu Yamasaki, on behalf of the ARTS-DN Japan Study Group:A randomized controlled study of finerenone versus placebo in Japanese patients with type 2 diabetes mellitus and
diabetic nephropathy, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 31:4;758-765, 2017.
7340B003 Hiroki Ito, Atsushi Nakagawa, Daisuke Koya:Reduced incretin effect in type 2 diabetes is mainly attributable to impaired glucose responsiveness of β-cells: evaluation via an oral sugar load under a hyperglycemic clamp, Journal
of Kanazawa Medical University, 42:1;7-16, 2017.
7340B004 Norikazu Ueki, Keizo Kanasaki, Megumi Kanasaki, Satoru Takeda, Daisuke Koya:Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II., Hypertension, 69:6;1156-
1164, 2017.
7340B005 Munehiro Kitada, Shin-ichi Tsuda, Kazunori Konishi, Ai Takeda-Watanabe, Mizue Fujii, Keizo Kanasaki, Makoto Nishizawa, Atsushi Nakagawa, Daisuke Koya:Anagliptin ameliorates albuminuria and urinary liver-type fatty acid- binding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent
manner., BMJ open diabetes research & care, 5:1;e000391, 2017.
7340B006 Jinpeng Li, Sen Shi, Swayam Prakash Srivastava, Munehiro Kitada, Takako Nagai, Kyoko Nitta, Miyuki Kohno, Keizo Kanasaki, Daisuke Koya:FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N- acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway, CELL DEATH & DISEASE, 8:e2965,
2017.
7340B007 Megumi Kanasaki, Swayam Prakash Srivastava, Fan Yang, Ling Xu, Sumiyo Kudoh, Munehiro Kitada, Norikazu Ueki, Hyoh Kim, Jinpeng Li, Satoru Takeda, Keizo Kanasaki, Daisuke Koya:Deficiency in catechol-o- methyltransferase is linked to a disruption of glucose homeostasis in mice, SCIENTIFIC REPORTS, 7:1;7927,
2017.
7340B008 Munehiro Kitada, Yoshio Ogura, Hiroko Maruki-Uchida, Masahiko Sai, Taeko Suzuki, Keizo Kanasaki, Yuna Hara, Hiromi Seto, Yuka Kuroshima, Itaru Monno, Daisuke Koya:The Effect of Piceatannol from Passion Fruit (Passiflora
edulis) Seeds on Metabolic Health in Humans, NUTRIENTS, 9:10;1142, 2017.
- 125 - 7340B009 (Per-Henrik Groop), Mark E Cooper, Vlado Perkovic, Berthold Hocher, Keizo Kanasaki, Masakazu Haneda, Guntram Schernthaner, Kumar Sharma, Robert C Stanton, Robert Toto, Jessica Cescutti, Maud Gordat, Thomas Meinicke, Audrey Koitka-Weber, Sandra Thiemann, Maximilian von Eynatten:Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: the randomized MARLINA-
T2D trial, DIABETES OBESITY & METABOLISM, 19:11;1610-1619, 2017.
7340B010 Munehiro Kitada, Yoshio Ogura, Taeko Suzuki, Itaru Monnno, Keizo Kanasaki, Ai Watanabe, Daisuke Koya:Cyclic and intermittent very low-protein diet can have beneficial effects against advanced diabetic nephropathy in Wistar
fatty (fa/fa) rats, an animal model of type 2 diabetes and obesity, NEPHROLOGY, 22:12;1030-1034, 2017.
7340B011 (Tsutomu Wada), Akari Ishikawa, Eri Watanabe, Yuto Nakamura, Yusuke Aruga, Hayate Hasegawa, Yasuhiro Onogi, Hiroe Honda, Yoshinori Nagai, Kiyoshi Takatsu, Yoko Ishii, Masakiyo Sasahara, Daisuke Koya, Hiroshi Tsuneki, Toshiyasu Sasaoka:Eplerenone prevented obesity-induced inflammasome activation and glucose
intolerance, JOURNAL OF ENDOCRINOLOGY, 235:3;179-191, 2017.
Reviews 7340C001 Yuta Takagaki, Daisuke Koya, Keizo Kanasaki:Dipeptidyl peptidase-4 inhibition and renoprotection: the role of
antifibrotic effects, CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 26:1;56-66, 2017.
7340C002 Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koya:Regulating Autophagy as a Therapeutic Target for
Diabetic Nephropathy., Current diabetes reports, 17:7;53, 2017.
7340C003 Keizo Kanasaki:DKD in elderly population, 75:11;1724-1732, 2017.
Short Communications 7340E001 Daisuke Koya:Impact of empagliflozin on diabetic kidney disease, JOURNAL OF DIABETES INVESTIGATION,
8:5;658-660, 2017.
Presentations at Conference
International Conference (Key Note Lecture)
7340G001 Daisuke Koya:Luseogliflozin in T2DM manegement, Diabetes Asia 2017, Kuala Lumpur, 2017.10.
International Conference (Symposium) 7340H001 Yuta Takagaki, Keizo Kanasaki, Makoto Kato, Daisuke Koya:Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice, 2017 Asia Islet Biology & Incretin Symposium (AASD Affiliated
Symposium), Seoul, 2017.03.
7340H002 Keizo Kanasaki:Symposium II The pathological role of endothelial DPP-4 in diabetic kidney fibrosis, 2017 Asia Islet
Biology & Incretin Symposium (AASD Affiliated Symposium), Seoul, 2017.03.
7340H003 Daisuke Koya:Symposium 1 Autophagy & diabetes Autophagy protects against kidney injury related to aging, obesity and diabetes, 3rd Korea-Japan Diabetes Forum in conjunction with 30th Spring Congress of Korean
Diabetes Association, Busan, 2017.05.
7340H004 Daisuke Koya:Nutrition, inflammation & metabolism Beneficial effects of calorie restriction and protein dilution,
The 37th Annual Meeting of the Korean Society of Nephrology (KSN2017), Seoul, 2017.05.
7340H005 Daisuke Koya:Experience in diabetes management across countries A truly Asian real world evidence of SGLT2i,
Diabetes Asia 2017, Kuala Lumpur, 2017.10.
International Conference (Presentations) 7340I001 Y.Takagaki, S.M.Lee, D.Zha, K.Kanasaki, D.Koya:Atg5 deficiency in endothelial cells contributes to the development of IL-6 dependent endothelial to mesenchymal transition and kidney fibrosis, 53rd Annual Meeting of
the European Association for the Study of Diabetes (EASD 2017), Lisbon, 2017.
- 126 - 7340I002 O.Tachibana, Y.Hayashi, Y.Sasagawa, S.Takada, A.Tamase, S.Shiraga, K.Okamoto, A.Nakagawa, D.Koya, M.Nakada, H. Iiduka:The efficacy of intra-operative topical dexamethasone administration on the prevention of Rathke cleft cyst re-accumulation and recurrence, The 1st meeting of Japan-China Neurosurgery Alliance, The 9th
Neurosurgery Conference of China and Japan, Zhengzhou Dengfeng, 2017.11.
- 127 - 7350 Division of Systems Bioscience for Drug Discovery Based on Intrinsically Disordered Proteins
Faculty
Title Name Field of Specialization Professor(Additional Post) TOMOSUGI Naohisa Clinical Proteomics Professor(Additional Post) ISHIGAKI Yasuhito Molecular and Cellular Biology Associate SHIMASAKI Takeo Medical Oncology, Gastroenterology, Bioinformatics Professor(Additional Post)
Publications
Originals 7350B001 (Kotaro Higashi), Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki, Yuka Nakamura, Manabu Oguchi, Tsutomu Takegami, Naoto Watanabe:High FDG uptake on PET is associated with negative cell-to-cell adhesion
molecule E-cadherin expression in lung adenocarcinoma., Annals of nuclear medicine, 31:590-595, 2017.
7350B002 S.Sakamoto, H.Kawabata, J.Kanda, T.Uchiyama, C.Mizumoto, T.Kitano, T.Kondo, M.Hishizawa, N.Tomosugi, A.Takaori-Kondo:High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet
engraftment after allogeneic hematopoietic stem cell transplantation., Cancer medicine, 6:1;120-128, 2017.
7350B003 Y.Yoshitomi, T.Ikeda, H.Saito, Y.Yoshitake, Y.Ishigaki, T.Hatta, N.Kato, H.Yonekura:JunB regulates angiogenesis
and neurovascular parallel alignment in mouse embryonic skin, Jonal of Cell Science, 130:5;916-926, 2017.
7350B004 Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata, Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.
7350B005 Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation of
multiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.
Reviews 7350C001 Arisawa Tomiyasu, Nakamura Masakatsu, Otsuka Toshimi, Jing Wu, Sakurai Naoko, Takano Hikaru, Hayashi Tasuku, Ota Masafumi, Nomura Tomoe, Hayashi Ranji, Shimasaki Takeo, Tahara Tomomitsu, Shibata Tomoyuki: Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative
colitis in Japan, WORLD JOURNAL OF GASTROENTEROLOGY, 23:29;5364-5370, 2017.
Presentations at Conference
International Conference (Presentations) 7350I001 Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P. Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.05.
7350I002 Tomiyasu.Arisawa, Hikaru.Takano, Tasuku.Hayashi, Wu .Jing, Masafumi.Ota, Tomoe.Nomura, Ranji.Hayashi, Toshimi.Otsuka, Takeo.Shimasaki, Masakatsu.Nakamura:THE PRE-MICRORNA938,TARGETING 1L-17L 3'- UTR,GENE POLYMORPHISMS IS ASSOCIATED WITH THE RISK FOR DAP-KINASE HYPERMETHYLATION
IN HP INFECTED JAPANESE SUBJECTS, DDW2017, Chicago, 2017.05.
7350I003 Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi Sasaki, Eri Kubo:Konck-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.12.
- 128 - 7400 Research Support Center
Faculty
Title Name Field of Specialization Professor(Additional Post) ISHIGAKI Yasuhito Molecular and Cellular Biology Epidemiology of cardiovascular diseases, occupational medicine, Professor NAKAGAWA Hideaki preventive medicine Senior Assistant Pathogenicity of flavivirus isolated from the field-collected MURAKAMI Manabu Professor(Additional Post) mosquitoes Senior Assistant Professor MIYAGOSHI Minoru Cell biology
Publications
Originals 7400B001 (Keiko Kubo), Kazuhiro Nogawa, Teruhiko Kido, Nishijo Muneko, Hideaki Nakagawa, Yasushi Suwazono:Estimation of Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants of an Environmentally Exposed River Basin in Japan, Risk analysis : an official publication of the Society for Risk
Analysis, 37:1;20-26, 2017.
7400B002 (Koshi Nakamura), Masaru Sakurai, Yuko Morikawa, Shin-ya Nagasawa, Katsuyuki Miura, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Motoko Nakashikma, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Serum ferritin, insulin resistance, and β-cell dysfunction: a prospective study in normoglycemic Japanese men, Experimental and
clinical endocrinology & diabetes, 125:1;12-20, 2017.
7400B003 M.Sakurai, K.Yoshita, K.Nakamura, K.Miura, T.Takamura, S-Y.Nagasawa, Y.Morikawa, T.Kido, Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, M.Ishizaki, H.Nakagawa:Skipping breakfast and 5-year changes in body mass
index and waist circumference in Japanese men and women, Obesity Science & Practice, 3:2;162-170, 2017.
7400B004 Shiga Hideaki, Taki Junichi, Okuda Koichi, Watanabe Naoto, Tonami Hisao, Nakagawa Hideaki, Kinuya Seigo, Miwa Takaki:Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients
with idiopathic olfactory dysfunction., Scientific reports, 7:1;3581, 2017.
7400B005 Tatsuya Koyama, Katsushi Yoshita, Nagako Okuda, Shigeyuki Saitoh, Kiyomi Sakata, Akira Okayama, Hideaki Nakagawa, Naoko Miyagawa, Katsuyuki Miura, Queenie Chan, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima: Overall nutrient and total fat intake among Japanese people: The INTERLIPID Study Japan, Asia Pacific journal of
clinical nutrition, 26:5;837-848, 2017.
7400B006 (Kotaro Higashi), Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki, Yuka Nakamura, Manabu Oguchi, Tsutomu Takegami, Naoto Watanabe:High FDG uptake on PET is associated with negative cell-to-cell adhesion
molecule E-cadherin expression in lung adenocarcinoma., Annals of nuclear medicine, 31:590-595, 2017.
7400B007 Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura:JunB regulates angiogenesis and
neurovascular parallel alignment in mouse embryonic skin, Jonal of Cell Science, 130:5;916-926, 2017.
7400B008 Yoichiro Hirakawa, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshitaka Murakami, Shigeyuki Saitoh, Hideaki Nakagawa, Akira Okayama, Akiko Tamakoshi, Kiyomi Sakata, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori Okamura, and the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN):Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group
(EPOCH-JAPAN)., Journal of epidemiology, 27:3;123-129, 2017.
7400B009 Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata, Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.
- 129 - 7400B010 Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Teruhiko Kido:Causes of death in patients with Itai-itai disease suffering from severe chronic cadmium poisoning: a nested case-control analysis of a
follow-up study in Japan, BMJ Open, 7:7;e015694, 2017.
7400B011 Murakami Manabu, Hori Kiyoe, Kitagawa Yoko, Oikawa Yosaburo, Kamimura Kiyoshi, Takagemi Tsutomu:An Ecological Survey of Mosquitoes and the Distribution of Japanese Encephalitis Virus in Ishikawa Prefecture, Japan,
between 2010 and 2014, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 70:4;362-367, 2017.
7400B012 (Kazuhiro Nogawa), Masaru Sakurai, Masao Ishizaki, Teruhiko Kido, Hideaki Nakagawa, Yasushi Suwazono: Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark
dose analysis, Journal of Applied Toxicology, 37:8;962-966, 2017.
7400B013 (Hoang Duc Phuc), Teruhiko Kido, Nguyen Thi Phuong Oanh, Ho Dung Manh, Le Thai Anh, Yuko Oyama, Rie Okamoto, Akie Ichimori, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Effects of aging on cadmium concentrations and renal dysfunction in inhabitants in cadmium-polluted regions in Japan., Journal of applied
toxicology, 37:9;1046-1052, 2017.
7400B014 (Xian Liang Sun), Teruhiko Kido, Seijiro Honma, Eitetsu Koh, Rie Okamoto, Ho Dung Manh, Shoko Maruzeni, Muneko Nishijo, Hideaki Nakagawa, Takeshi Nakano, Takumi Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le Ke Son:The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in
Vietnamese men, Science of the Total Environment, 595:842-848, 2017.
7400B015 Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation of
multiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.
7400B016 (Hirata Takumi), Sugiyama Daisuke, Nagasawa Shin-Ya, Murakami Yoshitaka, Saitoh Shigeyuki, Okayama Akira, Iso Hiroyasu, Irie Fujiko, Sairenchi Toshimi, Miyamoto Yoshihiro, Yamada Michiko, Ishikawa Shizukiyo, Miura Katsuyuki, Ueshima Hirotsugu, Okamura Tomonori:A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan., European journal of epidemiology, 32:547-557, 2017.
7400B017 Le Thai Anh, Teruhiko Kido, Seijiro Honma, Ho Dung Manh, Ikue Koike, Yuko Oyama, Hoang Duc Phuc, Rie Okamoto, Hideaki Nakagawa, Shoji F.Nakayama, Dang Duc Nhu, Nguyen Hung Minh, Ngo Van Toan, Le Ke Son: A relationship in adrenal androgen levels between mothers and their children from a dioxin-exposed region in Vietnam, The Science of the total environment, 607-608, 32-41, 2017.
7400B018 Nagako Okuda, Akira Okayam. Katsuyuki Miura, Katsushi Yoshita, Shigeyuki Saito, Hideaki Nakagawa, Kiyomi Sakata, Naoko Miyagawa, Queenie Chan, Paul Elliott, Hirotsugu Ueshima, Jeremiah Stamler: Food sources of dietary sodium in the Japanese adult population: the international study of macro-/micronutrients and blood pressure (INTERMAP), European Journal of Nutrition, 56:3;1269-1280, 2017.
Presentations at Conference
International Conference (Presentations) 7400I001 Shinya Nagasawa, Katsuyuki Miura, Masaru Sakurai, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yasushi Suwazono, Kazuhiro Nogawa, Hideaki Nakagawa:Longitudinal association between body weight change and 6-year
change of blood pressure in Japanese men, EPI|LIFESTYLE2017, Portland, 2017.03.
7400I002 Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.05.
7400I003 M.Nishijo, H.Nakagawa, K.Nogawa, T.Suwazono, T.Kido:Cancer mortality of residents living in the cadmium- polluted Jinzu River basin in Toyama,Japan, 14th International Conference on the Biogeochemistry of Trace
Elements, Zurich, 2017.07.
7400I004 Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi Sasaki, Eri Kubo:Konck-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.12.
- 130 -
Himi Municipal Hospital 9100 Himi Municipal Hospital
Faculty
Title Name Field of Specialization Director SAITO Hitoshi Surgical treatment of hepatobiliary and pancreatic disease Professor FUKUDA Akihiro Cardiology Professor TOMIOKA Ryo Neurology Professor KASAMAKI Yuji General Medicine Professor MORIYAMA Manabu Kidney transplantation，Urolithiasis Professor HATASHIMA Sunao Anesthesiology/Resuscitation studies Associate Professor KIYOSAWA Jun Cardiology Senior Assistant Professor SAITO Atsushi Nephrology Associate Professor ITO Tomohiko adrenal diseases, diabetes, thyroid diseases Associate Professor TSUDA Shinichi diabetes, hypertension, arteriosclerosis Associate Professor IGUCHI Masaharu Respiratory Medicine Associate Professor KUGINUKI Yasuaki Medical Radiography Associate Professor HATANO Eiju Spinal surgery Associate Professor MATSUNO Hideo Allergy，Otorhinolaryngology Associate Professor MATSUI Toshiaki Oral & Maxilofacial Surgery Senior Assistant Professor KOBATA Takashi Cardiovascular Surgery Senior Assistant Professor TAGUCHI Keita Orthopaedic surgery Senior Assistant Professor OHURA Kazuko Otorhinolaryngology Senior Assistant Professor KAWASAKI Masanori Anesthesiology/Resuscitation studies Assistant Professor MIZUNO Takuro Cardiology Assistant Professor YAMADA Shinya Respiratory Medicine Assistant Professor ISHIGAMI Keiichiro Gerontology Assistant Professor SANGEN Ryusho General Medicine Assistant Professor MUKAI Hirokado Oncology Surgery Assistant Professor HAYASHI Kei Oncology Surgery Assistant Professor NAKAMURA Kisuke Oncology Surgery Assistant Professor TAKAGI Sho Cardiovascular Surgery Assistant Professor KUSABA Eizo neurosurgery
Publications
Originals 9100B001 Masafumi Nojiri, Shiro Mizuno, Kazuaki Nishiki, Ryo Kato, Ken Nakagawa, Taku Oikawa, Masaharu Iguchi, Kazuhiro Osanai, Takeshi Ishizaki, Hirohisa Toga:ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema, Pulmonary Pharmacology & Therapeutics,
48(2018):80-87, 2017.
- 131 - 9100B002 Shiro Mizuno, Takeshi Ishizaki, Maiko Kadowaki, Masaya Akai, Kohei Shiozaki, Masaharu Iguchi, Taku Oikawa, Ken Nakagawa, Kazuhiro Osanai, Hirohisa Toga, Jose Gomez-Arroyo, Donatas Kraskauskas, Carlyne D Cool, Herman J Bogaard, Norbert F voelkel:p53 Signaling Pathway Polymorphisms Associated With Emphysematous
Changes in Patients With COPD, CHEST, 152:1;58-69, 2017.
Case Reports 9100D001 Mizuno Takuro, Kiyosawa Jun, Fukuda Akihiro, Watanabe Seiji, Kurose Nozomu, Nojima Takayuki, Kanda Tsugiyasu:Infective endocarditis following tumor necrosis factor-α antagonist therapy for management of psoriatic erythroderma: a case report., Journal of medical case reports, 11:1;35, 2017.
9100D002 Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda:Gastroenteritis in Japanese Females Caused by Shigella flexneri without Definite. Infection Route: A Case Report and Mini-Review of Literature, Journal Clinical Case Reports,
7:9;10001021, 2017.
9100D003 A.Takamura, R.Sangen, Y.Furumura, D.Usuda, Y.Kasamaki, T.Kanda:Diagnosis of myxedema coma complicated by
renal failure: a case report, Clinical Case Reports, 5:4;399-402, 2017.
9100D004 Daisuke Usuda, Masahisa Arahata, Kento Takeshima, Ryusho Sangen, Akiteru Takamura, Yasuhiro Kawai, Yuji Kasamaki, Yoshitsugu Iinuma, Tsugiyasu Kanda:A Case of Diffuse Large B-Cell Lymphoma Mimicking Primary
Effusion Lymphoma-Like Lymphoma, Case Reports in Oncology, 10:1013-1022, 2017.
- 132 -