This self-study report is based on the template for cyclical reviews within the Faculty of Medicine at the University of Toronto. It is timed to coincide with the search for a new Chair of the Department of Obstetrics and Gynaecology, as Dr. Alan Bocking completes his second five- year term in June of 2013.

The Department is the largest academic department of Obstetrics and Gynaecology in Canada, with 220 primary appointees and 47 cross-appointees. The teaching and research programs are located at 6 Fully-affiliated and 10 Community-affiliated hospital sites. There are currently 61 Residents and 57 subspecialty Clinical Fellows. The Department currently holds more than $15 million in research funding and has a robust publication record in all areas related to women's reproductive health.

Strengths of the Department include the broad and diverse clinical base, as well as excellent teachers at the Undergraduate and Postgraduate levels. In addition, the Department has developed a major focus on global women’s health and the early origins of health and disease as new and emerging areas of research and education.

This report provides detailed information regarding the various education and research programs, as well as views from undergraduate medical students and residents in Obstetrics and Gynaecology. Dr. Bocking has provided a personal report regarding the accomplishments of the Department over the last five years and some thoughts regarding Future Directions.

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2.1 Department Introduction

This Report follows the template for cyclical reviews as provided by the Dean’s Office and has been prepared by many Faculty and Staff within the Department of Obstetrics and Gynaecology. The Department is a multi-sited unit with 220 primary appointees and 47 cross-appointed faculty members. Our Faculty are located at 16 hospital sites (6 fully-affiliated and 10 Community- affiliates). The strengths of the Department are: 1) its size and access to a tremendous clinical resource for teaching and clinical research. 2) outstanding Postgraduate and Undergraduate Education Programs which will be described under Education and, 3) Basic Science and Translational Research.

The Department currently holds close to $15,000,000 in research funding, which is unparalleled in Canada for Departments of Obstetrics and Gynaecology. The research enterprise of the Department is located primarily in the Research Institutes of the fully-affiliated Hospitals (Mount Sinai Hospital/Samuel Lunenfeld Research Institute; Sunnybrook Health Sciences Centre/ Sunnybrook Research Institute; University Health Network and its Research Institute and St. Michael’s Hospital/Li Ka Shing Knowledge Institute).

The last 5 years for the Department have been highlighted by the major expansion of part-time and adjunct Faculty at the Community-affiliated Hospital sites in recognition of the significant role that integrated education plays in both the Undergraduate and Postgraduate programs. The opening of the Mississauga Academy with the addition of faculty at Credit Valley Hospital and Trillium Health Centre has provided the opportunity to enhance the exposure of our trainees to learning at these sites and will require significant support from the University Department in terms of both logistics and Faculty Development.

The Department underwent a Strategic Planning process in 2009 and identified 6 Strategic Directions with specific Goals and Implementation Priorities (See 2.11 Appendix: Strategic Plan). These Directions include: 1) Enhancing our Focus on Research 2) Developing our Community Teaching Sites and addressing gaps in our Core Curriculum 3) Clarifying and demonstrating our commitment to Social Responsibility as part of our academic responsibility 4) Recognizing, Valuing and Developing our Faculty and Staff 5) Strengthening our Communications infrastructure and re-enforcing our funding base 6) Developing Benchmarks for Excellence and monitoring our performance.

Each of these Strategic Directions align with the Strategic Planning Goals for the Faculty of Medicine for 2011 to 2016. This cyclical review and subsequent appointment of a new Chair will provide for further enhancement and refinement of these Directions. It is of note, however, that significant progress has been made over the last 3 years in each of these Directions by the Department of Obstetrics and Gynaecology. With regard to Research (Strategic Direction 1), the Department of Obstetrics and Gynaecology, in conjunction with the Department of Physiology, played a key role in supporting the Faculty of Medicine as the lead faculty for the establishment of the University of Toronto Institute of Human Development and it is of note that Dr. Stephen Lye, Vice-Chair, Research has been appointed as the inaugural Executive Director. In addition, Cyclical Review Fall 2012 Self-Study 4

the Department has now established secure and stable funding through the establishment of endowments (Hannah, Riley and Ludwig funds) for up to 3 Residents, concurrently, who wish to enroll in the Clinical Investigator Program.

In the domain of Education (Strategic Direction 2), the Department, under the leadership of Drs. Filomena Meffe, Heather Shapiro, and Donna Steele, has established important relationships with Faculty at Credit Valley Hospital and Trillium Health Centre and created pilot opportunities for both Clinical Clerks and Resident Electives/Selectives at these sites which have been very favourably received by both Faculty and Trainees. We anticipate that these will increase significantly over the next 12-24 months in parallel with both Undergraduate and Postgraduate medical expansion. The Department has expanded the role of the Fellowship Directors Committee and Dr. Shapiro, in her new role of Vice-Chair, Education takes on the responsibility of overseeing all of the Clinical Fellowship and Royal College Sub-specialty Resident programs, which will enable further standardization of these programs within the Department.

The Department makes a significant contribution locally, nationally and internationally in the area of Social Responsibility (Strategic Direction 3) through individual actions, leadership within organizations and programmatic development. In particular, through its participation in the AMPATH (Academic Model for Provision of Access to Health Care Consortium), the Department has established the framework for a long-term commitment to enhancing clinical care, research and teaching in Western Kenya. Drs. Astrid Christoffersen-Deb, Rachel Spitzer, Barry Rosen and Alan Bocking play key leadership roles within the Department in this Program and have been successful in obtaining both peer-review funding and philanthropic support for these activities. In 2010, the Department, under the leadership of Dr. Nan Okun, carried out a survey of faculty with regard to “Socially-responsible activities” and over half the Department members gave examples of such activities.

The Department continues to explore ways to further enhance its recognition of Faculty (Strategic Direction 4) through Departmental awards and communication of important internal and external awards that faculty members receive. The Leadership Council quarterly meetings and Annual Faculty Professional Development Day have been well received and there are opportunities for increasing these opportunities with focussed Faculty Development Programs. The Department has embarked on a major fund-raising effort (Strategic Direction 5) and currently supports a partial FTE Senior Development Officer within the Faculty of Medicine Advancement Office. The Department expects to play a major role in the soon-to-be launched Faculty of Medicine Boundless Campaign and has identified a number of priorities for fundraising which align with those of the University, as well as the Faculty of Medicine. The Department website needs attention and with the recent stabilization of the administrative staff at 92 College, this will be a high priority. The web-casting and videocasting of our monthly Interhospital Rounds have been well received and, except for the occasional ‘technical glitch“, have been very successful and are worthy of further expansion.

With regard to developing benchmarks (Strategic Direction 6), the Department has followed the work of the TAHSN Task Force on Valuing Academic Performance, as well as the Faculty Strategic Plan Implementation Working Group, in the identification of appropriate benchmarks for Research and Education. Over 95% of the full-time Faculty within the Department are now Cyclical Review Fall 2012 Self-Study 5

enrolled in Web CV and this will be a critical enabler for quantifying the contributions of the Department members, as well as for benchmarking. We expect to have 100% participation by the end of the current calendar year. A recent review by the Faculty of Medicine indicated that not all members acknowledge the University of Toronto in their publications, which limits our ability to compare ourselves to peer institutions. Rectifying this will be a major focus of the Leadership within the Department over the next 12 months.

The Department has recently undergone significant changes in administrative staff with the Undergraduate Co-ordinator accepting a promotion to another unit within the University of Toronto and the Business Manager also moving to another Faculty in the Spring of 2012. Both of these departures occurred at short notice, which meant the Department was functioning for approximately 2 months with a 50% reduction in administrative support. We are grateful to the Faculty of Medicine Dean’s office for its support during this time period and have now filled both these positions with outstanding new staff members.

The Department’s Research Day held in May was once again a great success and a tangible indicator of the research productivity and passion within the Department. Two members were successful in obtaining new Operating Grants in the most recent CIHR competition and the recruitment to the Twin Birth Study under the leadership of Dr. Jon Barrett was completed this past year, all of which are outstanding achievements.

The Undergraduate Medical Education Program in the Faculty of Medicine recently underwent a successful Accreditation. Although we await the full report, there do not appear to be any major areas of deficiency identified within the Obstetrics and Gynaecology components. In addition, for the last 4 years, the University of Toronto has ranked in the top quartile for performance by our graduates on the LMCC Part 1 Questions related to Obstetrics and Gynaecology. Each of the four Royal College of Physicians and Surgeons of Canada programs have undergone Internal Reviews in preparation for the On-Site Review by the Royal College to take place in April, 2013.

All Faculty, Staff and Postgraduate Trainees have been given an opportunity to contribute to the conduct and reporting of this self-study process. In particular, the “Report of the Faculty Members” was co-ordinated by Dr. Heather Shapiro and includes the results of an electronic survey of all Faculty members. The Residents have prepared a separate report of “Learners”, as have the current Undergraduate Medical Student Representatives on the Department Undergraduate Education Committee.

The previous External Review of the Department took place in December 2007 and was conducted by Dr. Michael Nelson, Washington University School of Medicine, St. Louis, Missouri and Dr. Robert Liston, University of British Columbia. Issues of risk identified at that time included: 1) The “funding mosaic” – this refers to the varying Practice Plans and levels of support provided by different institutions to Faculty within the Department at different sites. The Department of Obstetrics and Gynaecology is not unique within the University Of Toronto Faculty Of Medicine and this can be interpreted as one of its strengths or, alternatively, a weakness. The Department Chair approves all Conforming Practice Plans and two of the three existing plans use an Academic Activity based Compensation system Cyclical Review Fall 2012 Self-Study 6

for the distribution of Provincial Alternate Funding Plan dollars, which reward excellence as well as productivity. The remaining Practice Plan provides general support for all members and is currently addressing variations in support within the hospital site. All three Departments with Practice Plans are well supported by their respective host institutions. A major advance since the last review has been the implementation of stipends for part-time and adjunct teachers at the Community-affiliate sites which, although not large, is an important first step to recognize the important contributions that these individuals make to the Medical Education enterprise. 2) The “Recruitment and Support of Basic and Clinical Scientists“. This has not been perceived to be as much of an issue as previously and indeed it is believed that there is a good working relationship between the Chair, Vice-Chair Research, Clinical Chiefs and Research Directors at the fully-affiliated sites. A recent example of this is the appointment of Dr. Andras Nagy, Senior Scientist at the Samuel Lunenfeld Research Institute, and internationally recognized Stem Cell Biologist, to the Department of Obstetrics and Gynaecology as a primary appointee. 3) Concern was raised with regard to the absence of “secure” funding for the various Clinical Fellowships within the Department. Although this continues to be a concern, it is of note that the number of Clinical Fellows within the Department has increased from 30 to 50 per year during this time. Of note, is that the Department has implemented the standardization of remuneration principles, as well curriculum development and evaluation through POWER for Clinical Fellows, as recommended by the Faculty of Medicine Postgraduate Education Office. Ministry of Health Funding is now also provided for up to 6 eligible trainees in the 3 Royal College Accredited Subspecialty Programs (Maternal-Fetal Medicine, Gynaecologic Oncology and Gynaecologic Reproductive Endocrinology and Infertility). 4) Dependence upon Health Centres was identified as a potential risk and, as mentioned previously, this is seen more as a strength than a weakness and to date (despite Ministry funding cutbacks), the Department has been able to maintain excellence in its teaching and research programs, although this requires constant vigilance and communication amongst the Clinical and Academic Leaders. Members of the Department hold important leadership roles within the Greater Toronto Area and Ontario (eg. Physician Lead for Gynaecologic Surgery Wait-times in Ontario – Dr. Guylaine Lefebvre; Lead for Provincial Cervical Cancer Screening Programs – Dr. Joan Murphy; Chair, Ontario Prenatal Screening Program – Dr. Nan Okun; Member, Provincial Maternal-Newborn Advisory Committee – Dr. Mathew Sermer ). 5) Medical Class Expansion was also seen as a potential risk. We have seen elements of “learner crowding“ at some sites over the last year and anticipate that this will decrease significantly in 2013 when the first full rotation of Clinical Clerks takes place at the Mississauga Academy. In the meantime, we continue to work with Toronto East General Hospital and St. Joseph’s Health Centre to enhance the learning opportunities at those Cyclical Review Fall 2012 Self-Study 7

sites to ensure that all medical students obtain the range of exposure to learning opportunities offered at both fully-affiliate and community-affiliate sites. A major effort in Faculty Development is underway under the combined leadership of Drs. Filomena Meffe, Heather Shapiro and Jennifer Blake. The leadership at both Trillium Health Centre and Credit Valley Hospital have provided critical support for these initiatives. 6) The previous reviewers recommended that the Department explore potential models for Collaborative Perinatal Care. The Department has been a leader in many ways in promoting Interprofessional Education in Maternal/Newborn care with programs at St. Michael’s Hospital, Mount Sinai and North York General Hospitals. Although the provision of clinical care is beyond the scope of the Academic Department, members have provided leadership through multiple venues eg. the Hospital sites, Provincial Committees and nationally (APOG, SOGC). 7) The level of Administrative support for the Educational Programs was seen as a weakness in 2005 and since that time, the number of FTE’s supporting the Undergraduate and Postgraduate programs within the Department has increased from 1.5 to 2.5 FTE. A suggestion had also been made to “revisit“ the use of Standardized patients for the teaching of pelvic examinations to Medical Students. This has not been done since the current process of a combination of a video, mannequins and clinic teaching has been shown to be as effective and more sustainable than the use of standardized patients. 8) The reviewers highlighted the importance of Succession Planning to the overall success of the Department. We are indeed fortunate to have many talented and committed Faculty Members who have been willing to take on new roles. Most recently, Dr. Donna Steele has taken over as Director of the Obstetrics and Gynaecology Residency Training programme and Dr. John Kingdom has taken over as Head of the Division of Maternal- Fetal Medicine. Dr. Filomena Meffe has indicated her wish to step down as Director of the Undergraduate Education Program and therefore the Chair will be asking for Indications of Interest from Faculty members in this critical role. In addition, Dr. Bocking will be completing his term as Chair in June, 2013 and the Search Process for his successor has begun. Dr. Bocking has stepped down as Chief of the Department at Mount Sinai Hospital, University Health Network and Women’s College Hospital effective September 1, 2012 and Dr. Mathew Sermer will fill those roles as Interim Chief. An External Review of the MSH/UHN Department has taken place and the report from that review is pending. The Department has highlighted the need to encourage and support mid-career Faculty to take on these important clinical and academic leadership positions. Given the multiple demands on every Faculty member, it has been proposed that a “leadership mentorship” program be established within the Department. Former Chiefs and Chairs could assist with this important project. 9) Uncertainty remains as to the longevity of the 92 College Building, which was highlighted in 2007, with no substantive change since then. Cyclical Review Fall 2012 Self-Study 8

10) A recommendation to consider the establishment of a Division of General Obstetrics and Gynaecology was made by Drs. Liston and Nelson. This was discussed extensively amongst the General Obstetrician/Gynaecologists and the Department Executive and there did not appear to be an interest in doing so. This could always be reconsidered if the Department membership thought it would be helpful.

STRATEGIC PLAN

“Fostering Integration and Collaboration”

Strategic Directions, Goals and Implementation Priorities

November 2009

Executive Summary

On September 30, 2009, approximately 30 faculty and staff came together to participate in a follow up session to the University of Toronto Department of Obstetrics and Gynecology Strategic Planning retreat, “Fostering Integration and Collaboration”, which was held on June 11, 2009. At the June meeting, 43 participants heard from key academic, research and clinical leaders about changes in the external environment and issues and opportunities facing the Department in future years. Participants confirmed the departmental vision and collectively, proposed new strategic directions, goals and implementation priorities for the department for the next three to five years. A Summary of Proceedings and Strategic Directions document was prepared, reviewed by the Executive Committee of the Department and circulated to all faculty for feedback.

The meeting on September 30th, 2009 provided a further opportunity for all faculty and staff, including those who had not participated in the June 11th retreat, to:

. Confirm the new strategic directions and goals for the Department . Confirm the implementation priorities for the next 12 to 18 months . Identify the key enablers, resources and accountabilities for moving forward with these implementation priorities.

Dr. Bocking, Chair of the Department, began the meeting with an overview of the vision and strategic directions of the Department. He praised the Executive Committee and the Department for their hard work, commitment and support during the strategic planning process. Dr. Bocking outlined the key milestones in the strategic planning process and advice received from the Dean and Deputy Dean with respect to alignment with the Faculty of Medicine strategic directions and strategic plan implementation. He concluded by underscoring the importance of each of the proposed strategic directions and the goals that have been established for each area. The six strategic directions include:

1. Enhance our focus on research 2. Develop our community teaching sites and address our gaps in core curriculum 3. Clarify and demonstrate our commitment to social responsibility as part of our academic responsibility 4. Recognize, value and develop our Faculty and Staff 5. Strengthen our communications, infrastructure and funding base 6. Develop benchmarks for excellence and monitor our performance

The remainder of the planning session was spent in discussion and dialogue. Participants self- selected into five groups, each table addressing one of the above strategic directions. While the goals for Social Responsibility (3) were not discussed at this meeting, a new departmental Task Force on Social Responsibility will be established to confirm goals, priorities and an action plan for this new strategic direction.

Groups were asked to respond to the following questions and report back with highlights at the conclusion of the session.

Questions: . Did we get it right? Are these the right goals and actions? How would you modify to enhance? . Confirm the top two implementation priorities for the next 12 to 18 months. . Outline the key steps to move forward with these priority actions. . Who needs to be involved? Who is accountable? What key resources, people, infrastructure are required to get started?

A summary of the confirmed strategic directions and supporting goals are outlined in the charts on the following pages. Included as well are implementation priorities for each area for the next 12 to18 months and the key resources required to successfully execute on these priorities. Accountability structures are also identified.

Next Steps

The Executive Committee is currently reviewing the implementation priorities and developing an accountability framework, including timelines and measures to monitor progress towards achieving priorities and goals for the new strategic directions.

STRATEGIC DIRECTION 1: Enhance our focus on research

SUPPORTING GOALS & PRIORITY ACTIONS

PROPOSED STRATEGIC PRIORITIES DIRECTIONS AND SUPPORTING GOALS

1-1 Create a framework to . Develop an inventory of research activity, including contacts and enhance research within the areas of focus Department

. Confirm research priorities/themes and communicate to faculty, hospitals and other research partners.

. Increase collaborative grants in translational research

1-2 Build research . Formalize linkages and provide enhanced opportunities for infrastructure collaboration across Departments, hospital sites, and hospital-based research institutes.

. Identify funding sources for research

. Provide formal mentorship for junior faculty members interested in pursuing research

. Increase resident enrolment in Clinical Scientist Program

Recruit a research manager

1-3 Enhance communication . Establish research sub groups along university divisional linkages between hospitals lines to move translational research forward, e.g. Oncology, and research institutes Pediatrics and Adolescent Gynaecology, REI and MFM

. Provide a forum in which clinicians, researchers and trainees from these sub groups can meet with a view to sharing what each is doing, what resources are required, etc. Enhance readiness for multiple groups to participate in team granting opportunities.

. Identify a point person within each hospital responsible for knowing what research is under way and facilitate central communication within the Department

. Collaborate with hospital based research institutes to sponsor a Research Day to profile research under way within and across organizations

. Strengthen collaborations with basic science departments (e.g. IMS, Physiology) in a manner where contributions are visible and works to enhance translational research initiatives .

KEY RESOURCES

. Commitment from a diverse Research Committee to organizing research sub groups

. Technology support to build and enhance online capabilities; thus assisting with integration and collaboration

ACCOUNTABILITY

Research Committee

Division heads or their delegates would need to organize/formalize research groupings in their divisions

STRATEGIC DIRECTION 2: Develop our community teaching sites & address gaps in our core curriculum

SUPPORTING GOALS & PRIORITY ACTIONS

Goals Priorities

2.1 Address gaps in core . Compile inventory of current core curriculum materials and curriculum and confirm gaps teaching methodologies . Build flexibility into program to allow for more longitudinal experiences and introduce other methodologies to improve achievement of core activities

. Increase awareness of women’s health issues

. Explore other learning opportunities in the community by involving other health care providers

2.2 Develop core . Increase core sites to allow for deliver of core program community sites training

. Prepare faculty / staff for expansion of medical school including faculty development

. Increase distribution and profile of Medical Education within Department at all levels

. Expand role for teachers and learning opportunities at core community sites (i.e., partially-affiliated teaching hospitals)

. Continue to communicate/strengthen linkages with core sites by confirming local champions at each site (Southlake, Trillium, Credit Valley, Royal Victoria)

2.3 Support innovation . Expand innovative training models (e.g., simulation labs; and flexibility in models to shorten length of training) introducing new training models . Leverage new opportunities arising from expansion of the distributive education model emerging in the GTA and beyond

. Promote greater flexibility around processes (i.e., 6 week clerkship – discuss with paediatrics, family medicine, anaesthesia)

. Pursue development of new ways of training (e.g., interprofessional training approaches; combining training with research and sub-specialty training) . Standardize Fellowship Training Programs within Department 2.4 Prepare for expansion of residency and . Measure graduate outcome (location, satisfaction) –by fellowship training alumni affiliation programs

. Enhance funding sources for Clinical Fellowships . Mandate logging cases and log books for trainees

. Appoint an Associate Director for Residency Training Program

2.5 Clarify expectations . Define consistent standards and establish levels of re: faculty commitment for faculty. performance . Confirm evaluation techniques and performance measures

KEY RESOURCES

. People (see accountabilities)

COMMUNITY TEACHING SITES

. Individual is required to lead task force on Expansion

. Educational Coordinator at each site to build familiarity with issues

. Administrative support to expand access to the teaching portal and assist with formalizing processes

. Communication and feedback portals (web based technology)

ACCOUNTABILITY

. Education Committees, with Faculty and Administrative Assistants involvement

. Need for commitment and support from Hospital Department Chiefs.

STRATEGIC DIRECTION 3: Clarify and demonstrate our commitment to social responsibility as part of our academic responsibility

SUPPORTING GOALS & PRIORITY ACTIONS

Goals Priorities

3.1 Develop an inventory . Increase understanding of ob/gyn specialty of current advocacy/ social responsibility . Engage all faculty in a dialogue around social responsibility initiatives and what it means for the Department . Collaborate with the FOM Social Responsibility Working

Group and the Dalla Lana School of Public Health to undertake a needs assessment and develop an inventory of current advocacy and outreach initiatives

3.2 Enhance capacity to . Create working groups to develop a needs-based curriculum match trainees to to address the following: Local/ Community/ Global local, community and outreach (e.g. aboriginal health) global needs . Incorporate the principles of population health and determinants of health into program planning

3.3 Enhance reach of . Develop methods of engagement to attract all levels of teaching/ training faculty to participate in SR programs through involvement in global health . Create an online repository site for international teaching programs initiatives and opportunities . Create opportunities for on line web based education

opportunities.

. Provide linkages to other resources

. Leverage successful programs, e.g. MOI University, Kenya; Ethiopia (with other FOM departments)

KEY RESOURCES

. Lead contact to coordinate efforts and communicate best practices

. Create a central portal to communicate ideas and share social responsibility initiatives

ACCOUNTABILITY

Task force on Social Responsibility to be established STRATEGIC DIRECTION 4: Recognize, Value and Develop our faculty and Staff

SUPPORTING GOALS & PRIORITY ACTIONS

Goals Priorities

4.1 Increase faculty . Define faculty relationship to the University; clarify shared affiliation with and benefits of relationship value to the . Enhance the awareness and recognition of contributions of University faculty members to the University

. Identify and develop ways to compensate or otherwise recognize the contributions to the university in a manner that encourages participation

. Increase department faculty participation on University committees

. Revisit and increase rewards/awards to faculty (link awards to evaluation)

. Explore seed, infrastructure money for grants

. Establish mechanisms to enhance loyalty and association with University, e.g. have the same email identifier (@utorob.gyn); create opportunities to meet with the Dean

4.2 Recruit and retain . Develop a Human Resources Strategic Plan top-quality faculty . Confirm Department needs (research, education, social responsibility) within the University and then search/advocate through hospitals to address needs

. Target recruitment by: identifying talent early and supporting development of academic potential; providing infrastructure, benefits, and mentoring; and identifying key partners to support recruitment efforts (e.g., Department of Medicine, Research Institutes, Dalla Lana School of Public Health)

. Target retention strategies by: Clarifying guidelines re: promotion/progression; Confirming resources to reward and enable success (e.g., recognition award re: value of academic advancement); Developing grants to build capacity and interest (e.g., STIRRHS Grant); Clarifying requirements for staff and faculty promotion 4.3 Enhance mentorship . Increase emphasis on mentoring and faculty development programs . Work with Centre for Faculty Development to develop effective mentorship strategies for various stages of career path, including junior, mid-career and senior faculty; consider needs of new teaching faculty in distributed community teaching sites

. Institute resident-to-resident mentorship program

. Increase emphasis on mentoring and faculty & staff development, aligning with education faculty development requirements. Take better advantage of senior faculty within the Department.

KEY RESOURCES

. Technology support, create a central email database specific to UofT

. Human Resources to assist with potential UofT affiliated hospital rotational program

. Develop an outlet for senior faculty and staff to share their learnings and best practices

. Support from Faculty, Staff and Alumni

ACCOUNTABILITY

Leadership Council

. Assign tasks to Appointments Committee

STRATEGIC DIRECTION 5: Strengthen our communications infrastructure and reinforce our funding base

SUPPORTING GOALS & PRIORITY ACTIONS

Goals Priorities

5.1 Establish a central . Invest and/or link with other Departments to strengthen repository to existing technology and enhance connectivity between sites provide a ‘virtual’ focal point for the . Augment website Department . Retain technical support required for enhanced communications and connectivity

. Hire a dedicated staff member with technical expertise to manage the expansion of the website and develop an interactive blog

. Establish responsible person at each site to work with central department to enhance connectivity

. Collaborate and learn from other departments that have functional systems in place (e.g. Department of Medicine, DFCM); explore city-wide grand rounds by videoconference

5.2 Establish a physical . Ensure a physical focal point within the Department focal point and other central . Augment resources for administrative support supports for the . Coordinate a mechanism for regular collaboration among Department support and administrative assistants across hospitals . Sponsor an Annual Research & Education Day to highlight research, advocacy/outreach activities, expansion of education activities, etc.

5.3 Strengthen funding . Increase fundraising for Endowed Chairs, Professorships, base including Fellowships and Studentships building alternative . Explore hiring dedicated advancement officer to work in revenue sources collaboration with FOM Advancement Office

. Enhance partnerships with hospital foundations

. Develop engagement strategies for alumni

. Revisit Genesis’s mandate and responsibility for fundraising

. Reconvene Finance Committee and develop funding strategy

KEY RESOURCES

For enhanced communications and connectivity

. Additional technical support for enhanced communications

. Volunteer / Point-of-contact from each hospital (physician) as resource to new technical/communications resource

For Funding

. Create a new full-time Fundraiser position to be shared with other departments

. Secure funding for new position

ACCOUNTABILITY

Executive Chair & Business Manager

STRATEGIC DIRECTION 6: Develop benchmarks for excellence and monitor our performance

SUPPORTING GOALS & PRIORITY ACTIONS

Goals Priorities

6.1 Develop benchmarks . Direct resources to strengthen evaluation of impact of (quality indicators) for research activities within the Department research standards . Establish new benchmarks for research outside of traditional number of publications and citations, e.g. number of abstracts to papers, number of people involved in grants

6.2 Develop benchmarks . Develop an inventory of what is currently being and measures for benchmarked/ measured and assess relevance for evaluation of development of Departmental benchmarks undergraduate and post graduate training . Confirm benchmarks/measures to evaluate success.

6.3 Establish mechanism . Establish a working group to develop a department to monitor and track framework for benchmarks and performance measures. performance against benchmarks . Collaborate with FOM Benchmarking Expert Panel for advice regarding measures and approaches to monitoring performance towards benchmarks

. Clearly define roles and responsibilities for new hires and existing staff, and encourage collaboration of resources, ideas and work efforts

KEY RESOURCES

. Appoint a Research Manager in the Research Office to facilitate the strategy

. Establish incentives to encourage effective strategy execution (e.g. fund completed papers, not abstracts)

ACCOUNTABILITY

Leadership Council

Task force may be established

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2.2 Report of the Chair Dr. Alan Bocking

It has been a distinct pleasure and honour to have served as the Gordon C. Leitch Chair of the Department of Obstetrics and Gynaecology for the last 9 ½ years. When I joined the University of Toronto Department in April, 2003, it was at the height of SARS. My first three months were characterized by the cancellation of meetings, conferences, Research Day and the conduct of all official University and Hospital Business essentially by teleconference. Despite the sense of social isolation this invoked for everyone, we persevered and I believe became a stronger Department despite this tragic circumstance.

In 2003, there were 120 Faculty members and today we have 220 primary appointees and 47 cross-appointees from 12 different Departments. In 2003, there were 35 residents in Obstetrics and Gynaecology and 20 Subspecialty Fellows. Today, there are 60 Residents and 50 Fellows. This is unprecedented growth in the Department and, in combination with the increased Undergraduate Medical Class, as well as the establishment of the Mississauga Academy, this has created new opportunities and challenges for the Department. When I joined the University of Toronto, the merger of the Departments of Obstetrics and Gynaecology at Mount Sinai Hospital and University Health Network had just taken place and this had created the largest single Hospital-based Department of Obstetrics and Gynaecology in Canada and possibly North America. In addition, the Department had an already strong affiliation with the Samuel Lunenfeld Research Institute, with unprecedented support from Mount Sinai Hospital for Clinical and Basic Research in our field. This, in combination with the extensive and diverse Clinical programs in Obstetrics and Gynaecology, led me to conclude that it would be best for the Department for me to be the Chief of the joint department at MSH and UHN. I am deeply indebted to Joe Mapa, CEO of Mount Sinai Hospital, as well as the Department members, for their unwavering support for me between 2003 and the present.

The MSH/UHN Department is strong and has many talented leaders which has contributed to my decision to step down as Chief in order to focus my efforts on Research and Integrated Education, as well as Faculty Development .Dr. Mathew Sermer has been the Associate Chief of the Department at MSH/UHN and I am confident that he will do an outstanding job as Interim Chief. I have also enjoyed the opportunity to work with some incredibly talented leaders, including Dr. Guylaine Lefebvre, who has just been re-appointed for a further 2 year term as Chief of the Department of Ob/GYN at St. Michael’s Hospital and Dr. Jennifer Blake, former Chief at Sunnybrook Health Sciences Centre.

Dr. Blake had a particularly challenging time as leader of a joint Department during the period of time when Women’s College Hospital had initially merged with Sunnybrook Health Sciences Centre and then “demerged” in 2005. Fortunately, the Department is now well established at the Bayview Campus with beautiful new physical facilities and a strong host hospital, where Dr. Art Zaltz is doing an outstanding job as Interim Chief. Women’s College Hospital has also established itself as an Academic Ambulatory Care Hospital and has embraced Gynaecology as a leading discipline for development under the leadership of Dr. Lisa Allen as Site Chief.

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We are very fortunate to have outstanding clinical leadership at our Community-affiliate Hospitals and we rely heavily on these individuals to be role models and champions for Teaching and Research, in addition to ensuring high Standards of Quality of Care, Patient Safety and Physician Performance.

I am deeply indebted to all these individuals, who I have worked with since 2003. I will provide further reflections and comments in the section of this report entitled Future Directions.

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3.1 Faculty Demographics

The Department of Obstetrics and Gynaecology currently consists of 220 primary appointees and 47 cross-appointees from 12 separate University of Toronto Departments (Radiation Oncology, Laboratory Medicine and Pathology, Clinical Biochemistry, Paediatrics, Medicine, Physiology, Anaesthesia, Medical Imaging, Family and Community Medicine, Dalla Lana School of Public Health, Psychiatry and Molecular Genetics.

Of the 220 Primary appointees, 100 are Clinical Fulltime; 85 are Clinical Part-time; 18 are Adjunct ; 10 are Status-only and 7 are Professor Emeritus. For a complete list of the Faculty, please see Appendices 3.2.1 and 3.2.2. The academic ranks of the Fulltime and Status-only Department are as follows:

Full Professor – 21 Associate Professor – 25 Assistant Professor – 80 Lecturer – 80

We have included curriculum vitae of our faculty members on an accompanying USB stick. Please see a list of the faculty included in section 14. Faculty CVs.

The Department is also supported by a Fulltime Business Manager, Department Administrative Assistant, Co-ordinator of Postgraduate Education Programs plus 0.5 Assistant, Co-ordinator of Undergraduate Education Programs, 0.5 FTE Professional Educator and a Research Consultant.

As in most Faculty of Medicine Clinical Departments, the recruitment of faculty is largely dependant upon the availability of Clinical resources at the Hospital sites. These include, but are not limited, to OR time, Inpatient beds, Delivery Volumes, Clinic and Office space. Research resources are also generally provided by the Hospital-based Research Institutes and, in particular, the Samuel Lunenfeld Research Institute, UHN Research Institute, the Sunnybrook Research Institute and the Li Ka Shing Knowledge Institute. As a result, human resource planning requires frequent and open communication amongst the Chair and the Hospital Chiefs.

For new recruitments requiring research resources, the VP-Research at the relevant site also plays a key role. The Department has been fortunate to have a very good working relationship with the VP’s Research at the fully-affiliated hospitals with which we are associated. One of the strengths of the Department has been the close relationship with the Institutes and this has facilitated the creation of research teams consisting of Clinicians, Clinician-Scientists and Basic Scientists. The Department currently has 7 fulltime status-only Scientists based at the SLRI (Drs. Adamson, Lye, Jurisicova, Rogers, Brown, Caniggia and Nagy ) and 4 Clinician Scientists at MSH (Drs. Kingdom, Murphy, Bocking and Casper). One Clinician Scientist is based at the Sunnybrook Health Sciences Centre ( Dr. Barrett ) and there are a number of Clinician Investigators ( ~ 30 % of time in Research ) at each of the fully-affiliated sites. The Department currently has 2 members who hold Canada Research Chairs (Drs. Stephen Lye – Tier 1 and Andrea Jurisicova – Tier 2 ).Three members are SLRI Senior Scientists with salary support from the SLRI and 2 members are supported by a combination of Department funds, Practice Plan Cyclical Review Fall 2012 Self-Study 12

funds and Grants. A risk to the Department is the ongoing support for some of these highly productive Scientists.

There are also a number of members who hold endowed Chairs (Dr. Alan Bocking – Gordon C. Leitch Chair; Dr. John Kingdom – Rose Torno Chair at MSH; Dr. Joan Murphy – J. Douglas Crashley Chair at UHN; and Dr. Guylaine Lefebvre – Women’s Health Chair at SMH).The recently established Institute of Human Development provides an opportunity for further recruitment to the Department with expertise in Genetics, Epigenetics, and Genetic Epidemiology and Health Outcomes Research. In addition, the establishment of expertise and partnerships in Women’s Reproductive Global Health (Drs. Spitzer, Christoffersen-Deb and Rosen ) provides the opportunity for further expansion and recruitment to a create a critical mass of investigators in the areas of Maternal-Newborn Health, Family Planning and Gynaecologic Cancer). These recruitments could take place in collaboration with other Departments such as Paediatrics, Medicine and the Dalla Lana School of Public Health.

Department of Obstetrics and Gynaecology Faculty of Medicine, University of Toronto

3.1.1 Department of Obstetrics & Gynaecology Primary Appointments PRIMARY FullNAME LastName HOSPITAL RANK STATUS Department Dr. Sergey Moskovtsev CReATe Fertility Centre Assistant Professor Status-only (Non-MOBGYN Dr. Aleksandre Corbey CREDIT VALLEY HOPSITAL Lecturer Part-time OBGYN Dr. Patricia Doyle CREDIT VALLEY HOPSITAL Lecturer Part-time OBGYN Dr. Gwendolyn Goodrow CREDIT VALLEY HOPSITAL Lecturer Part-time OBGYN Dr. Paul Gurland CREDIT VALLEY HOPSITAL Lecturer Part-time OBGYN Dr. Mathias Gysler CREDIT VALLEY HOPSITAL Assistant Professor Part-time OBGYN Dr. Allan Kanee CREDIT VALLEY HOPSITAL Lecturer Part-time OBGYN Dr. Sylvie Leone-Tomaschoff CREDIT VALLEY HOPSITAL Lecturer Part-time OBGYN Dr. Kerry Myckan CREDIT VALLEY HOPSITAL Lecturer Part-time OBGYN Dr. John Robert Smith CREDIT VALLEY HOPSITAL Lecturer Part-time OBGYN Dr. Scott Tigert CREDIT VALLEY HOPSITAL Lecturer Part-time OBGYN Dr. Carol Wade CREDIT VALLEY HOPSITAL Lecturer Part-time OBGYN Dr. Nicolette CacciaN HOSPITAL FOR SICK CHILDREN Assistant Professor Part-time OBGYN Dr. Craig Pennell KING EDWARD MEMORIAL HOSPITAL Adjunct Professor Adjunct Professor ( OBGYN Dr. George Arnold MARKHAM-STOUFFVILLE HOSPITAL Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Gita Singh MARKHAM-STOUFFVILLE HOSPITAL Adjunct Lecturer Adjunct Lecturer OBGYN Dr. S. Lee Adamson MOUNT SINAI HOSPITAL Professor Status-only (Non-MOBGYN Dr. May Alarab MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Lisa AllenLi MOUNT SINAI HOSPITAL Associate Professor Full-time OBGYN Dr. Rebecca Arthur MOUNT SINAI HOSPITAL Lecturer Full-time OBGYN Dr. Marshall Barkin MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Paul Bernstein MOUNT SINAI HOSPITAL Professor Full-time OBGYN Dr. Alan D. Bocking MOUNT SINAI HOSPITAL Professor Full-time OBGYN Dr. Theodore J. Brown MOUNT SINAI HOSPITAL Professor Status-only (Non-MOBGYN Dr. Kenneth Cadesky MOUNT SINAI HOSPITAL Assistant Professor Part-time OBGYN Dr. Isabella Caniggia MOUNT SINAI HOSPITAL Professor Status-only (Non-MOBGYN Dr. Robert Casper MOUNT SINAI HOSPITAL Professor Full-time OBGYN Dr. Barbara Cruickshank MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Harold Drutz MOUNT SINAI HOSPITAL Professor Full-time OBGYN Dr. Frederic Engle MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Dan Farine MOUNT SINAI HOSPITAL Professor Full-time OBGYN Department of Obstetrics and Gynaecology Faculty of Medicine, University of Toronto

Dr. Michele Farrugia MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Eve Fried MOUNT SINAI HOSPITAL Lecturer Part-time OBGYN Dr. Douglas Gare MOUNT SINAI HOSPITAL Professor Emeritus Professor Emeritus OBGYN Dr. Dimitrios Giannoulias MOUNT SINAI HOSPITAL Lecturer Full-time OBGYN Dr. Ellen Greenblatt MOUNT SINAI HOSPITAL Associate Professor Full-time OBGYN Dr. Peter Hawrylyshyn MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Andrea Jurisicova MOUNT SINAI HOSPITAL Associate Professor Full-time OBGYN Dr. Johannes Keunen MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. John Kingdom MOUNT SINAI HOSPITAL Professor Full-time OBGYN Dr. Yolanda Kirkham MOUNT SINAI HOSPITAL Lecturer Part-time OBGYN Dr. Elyse Levinsky MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Kimberly Liu MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Ron A. Livingstone MOUNT SINAI HOSPITAL Professor Emeritus Professor Emeritus OBGYN Dr. Danny Lovatsis MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Stephen Lye MOUNT SINAI HOSPITAL Professor Status-only (Non-MOBGYN Dr. Elliott Lyons MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Ann Kinga Malinowski MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Cynthia Maxwell MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Matthew Morton MOUNT SINAI HOSPITAL Lecturer Full-time OBGYN Dr. Kellie E. Murphy MOUNT SINAI HOSPITAL Associate Professor Full-time OBGYN Dr. Andras Nagy MOUNT SINAI HOSPITAL Professor Status-only (Non-MOBGYN Dr. Nanette Okun MOUNT SINAI HOSPITAL Associate Professor Full-time OBGYN Dr. Wusun Paek MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. J. W. Knox Ritchie MOUNT SINAI HOSPITAL Professor Full-time OBGYN Dr. Ian Rogers MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Greg Ryan MOUNT SINAI HOSPITAL Professor Full-time OBGYN Dr. Gareth Seaward MOUNT SINAI HOSPITAL Professor Full-time OBGYN Dr. Amanda Selk MOUNT SINAI HOSPITAL Lecturer Part-time OBGYN Dr. Mathew Sermer MOUNT SINAI HOSPITAL Professor Full-time OBGYN Dr. Heather Shapiro MOUNT SINAI HOSPITAL Associate Professor Full-time OBGYN Dr. Jodi Shapiro MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Rachel Spitzer MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Michael Sved MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Jackie Thomas MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Department of Obstetrics and Gynaecology Faculty of Medicine, University of Toronto

Dr. Wendy Whittle MOUNT SINAI HOSPITAL Assistant Professor Full-time OBGYN Dr. Rory Windrim MOUNT SINAI HOSPITAL Professor Full-time OBGYN Dr. Wendy Wolfman MOUNT SINAI HOSPITAL Associate Professor Full-time OBGYN Dr. Adrian Brown NORTH YORK GENERAL HOSPITAL Assistant Professor Full-time OBGYN Dr. Dennis Chu NORTH YORK GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Shlomo Grynspan NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Man Fan Ho NORTH YORK GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Angela Kang NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Danny Kreichman NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Elyse Lackie NORTH YORK GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Sabrina Lee NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Alexandra Nevin Lam NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Robert Derek Nicholson NORTH YORK GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Titus Owolabi NORTH YORK GENERAL HOSPITAL Associate Professor Emeritus Associate ProfessorOBGYN Dr. Nicholas Pairaudeau NORTH YORK GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. David Rosenthal NORTH YORK GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Nicholas Shilleto NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Paul Shuen NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Kirsten Smith NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Linda Stirk NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Modupe Tunde-Byass NORTH YORK GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Jeremy C. Wong NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Lynne Zolis NORTH YORK GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Marcus Bernardini PRINCESS MARGARET HOSPITAL Assistant Professor Full-time OBGYN Dr. (Denny) A.D. DePetrillo PRINCESS MARGARET HOSPITAL Professor Emeritus Professor Emeritus OBGYN Dr. Jason Dodge PRINCESS MARGARET HOSPITAL Assistant Professor Full-time OBGYN Dr. Sarah Ferguson PRINCESS MARGARET HOSPITAL Assistant Professor Full-time OBGYN Dr. Stephane Laframboise PRINCESS MARGARET HOSPITAL Assistant Professor Full-time OBGYN Dr. Gordon Lickrish PRINCESS MARGARET HOSPITAL Professor Emeritus Professor Emeritus OBGYN Dr. K. Joan Murphy PRINCESS MARGARET HOSPITAL Associate Professor Full-time OBGYN Dr. Barry Rosen PRINCESS MARGARET HOSPITAL Professor Full-time OBGYN Dr. William A. Easton ROUGE VALLEY HEALTH SYSTEM - SCARBOROUGH CEAssistant Professor Part-time OBGYN Dr. Terry E. Logaridis ROUGE VALLEY HEALTH SYSTEM - SCARBOROUGH CELecturer Part-time OBGYN Dr. Joanne Ma ROUGE VALLEY HEALTH SYSTEM - SCARBOROUGH CEAdjunct Lecturer Adjunct Lecturer OBGYN Department of Obstetrics and Gynaecology Faculty of Medicine, University of Toronto

Dr. Shannon Causey ROYAL VICTORIA HOSPITAL - BARRIE Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Enrique Reyes ROYAL VICTORIA HOSPITAL - BARRIE Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Jan Scheeres ROYAL VICTORIA HOSPITAL - BARRIE Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Vincent Wu ROYAL VICTORIA HOSPITAL - BARRIE Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Paul Thistle SALVATION ARMY HOWARD HOSPITAL Adjunct Professor Adjunct Professor OBGYN Dr. Erica Mantay SOUTHLAKE REGIONAL HEALTH CENTRE Lecturer Part-time OBGYN Dr. Peter Watt SOUTHLAKE REGIONAL HEALTH CENTRE Lecturer Part-time OBGYN Dr. Clarissa Bambao ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Melanie Caetano ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Nicole Cherry ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Lanval Daly ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Alfonso Del Valle Rebeil ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Anthony Di Pierdomenico ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Beata Grygowski ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Sybil Judah ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Mary Melchior ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Esther Park ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Edward Ryan ST. JOSEPH'S HEALTH CENTRE Lecturer Part-time OBGYN Dr. Artin Ternamian ST. JOSEPH'S HEALTH CENTRE Associate Professor Part-time OBGYN Dr. Suzanne Wong ST. JOSEPH'S HEALTH CENTRE Assistant Professor Part-time OBGYN Dr. Howard Berger ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Christine M. Derzko ST. MICHAEL'S HOSPITAL Associate Professor Part-time OBGYN Dr. Tatiana Freire-Lizama ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. A.H. Gerulath ST. MICHAEL'S HOSPITAL Associate Professor Full-time OBGYN Dr. Stephen Im ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Sari Kives ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Andrea Lausman ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Guylaine Lefebvre ST. MICHAEL'S HOSPITAL Professor Full-time OBGYN Dr. Adelmo Martoglio ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Paul McCleary ST. MICHAEL'S HOSPITAL Associate Professor Full-time OBGYN Dr. Colleen McDermott ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Filomena Meffe ST. MICHAEL'S HOSPITAL Associate Professor Full-time OBGYN Dr. Eva Mocarski ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Deborah Robertson ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Department of Obstetrics and Gynaecology Faculty of Medicine, University of Toronto

Dr. Abheha Satkunaratnam ST. MICHAEL'S HOSPITAL Lecturer Full-time OBGYN Dr. Rajiv Shah ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Eliane Shore ST. MICHAEL'S HOSPITAL Lecturer Part-time OBGYN Dr. Dana Soroka ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Donna Steele ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Wilf Steinberg ST. MICHAEL'S HOSPITAL Assistant Professor Full-time OBGYN Dr. Karen Tessler ST. MICHAEL'S HOSPITAL Assistant Professor Part-time OBGYN Dr. Mark Yudin ST. MICHAEL'S HOSPITAL Associate Professor Full-time OBGYN Dr. Hani Akoury SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Jon Barrett SUNNYBROOK HEALTH SCIENCES CENTRE Associate Professor Full-time OBGYN Dr. Jennifer Blake SUNNYBROOK HEALTH SCIENCES CENTRE Professor Full-time OBGYN Dr. Janet Bodley SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Howard Cohen SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Allan L. Covens SUNNYBROOK HEALTH SCIENCES CENTRE Professor Full-time OBGYN Dr. Marjorie Dixon SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Nancy Durand SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Lilian Gien SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Karen Glass SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Mary E. Hannah SUNNYBROOK HEALTH SCIENCES CENTRE Professor Full-time OBGYN Dr. Elaine Herer SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Dini Hui SUNNYBROOK HEALTH SCIENCES CENTRE Lecturer Full-time OBGYN Dr. Jamie Kroft SUNNYBROOK HEALTH SCIENCES CENTRE Lecturer Full-time OBGYN Dr. Rose Kung SUNNYBROOK HEALTH SCIENCES CENTRE Associate Professor Full-time OBGYN Dr. Rachel Kupets SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Noor Ladhani SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Patricia Lee SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Clifford Librach SUNNYBROOK HEALTH SCIENCES CENTRE Associate Professor Full-time OBGYN Dr. Kay I. Lie SUNNYBROOK HEALTH SCIENCES CENTRE Associate Professor Full-time OBGYN Dr. Grace Liu SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. J.E. (Ted) Morgan SUNNYBROOK HEALTH SCIENCES CENTRE Professor Emeritus Professor Emeritus OBGYN Dr. H.S. Morris SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Ori Nevo SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Raymond Osborne SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Richard Pittini SUNNYBROOK HEALTH SCIENCES CENTRE Associate Professor Full-time OBGYN Department of Obstetrics and Gynaecology Faculty of Medicine, University of Toronto

Dr. R. Michael Shier SUNNYBROOK HEALTH SCIENCES CENTRE Professor Full-time OBGYN Dr. Sony Sierra SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Danielle Vicus SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Fay Weisberg SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Herb Wong SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Arthur Zaltz SUNNYBROOK HEALTH SCIENCES CENTRE Assistant Professor Full-time OBGYN Dr. Yaakov Bentov TCART Assistant Professor Part-time OBGYN Dr. Paul Chang TCART Lecturer Part-time OBGYN Dr. Navid Esfandiari TCART Assistant Professor Status-only (Non-MOBGYN Dr. Mary Cheng THE SCARBOROUGH HOSPITAL Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Stacy Costa THE SCARBOROUGH HOSPITAL Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Joseph Cramer THE SCARBOROUGH HOSPITAL Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Jevan Ko THE SCARBOROUGH HOSPITAL Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Asha Kurup THE SCARBOROUGH HOSPITAL Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Haidar Mahmoud THE SCARBOROUGH HOSPITAL Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Nathan Roth THE SCARBOROUGH HOSPITAL Lecturer Part-time OBGYN Dr. Michael Silver THE SCARBOROUGH HOSPITAL Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Nina Venkatarangam THE SCARBOROUGH HOSPITAL Adjunct Lecturer Adjunct Lecturer OBGYN Dr. Georgina Wilcock THE SCARBOROUGH HOSPITAL Lecturer Part-time OBGYN Dr. Anjali Aggarwal TORONTO EAST GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Oluleke Badmos TORONTO EAST GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Samir Batarseh TORONTO EAST GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Yoav Brill TORONTO EAST GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Jennifer Cram TORONTO EAST GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Maja Gans TORONTO EAST GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Murray Kroach TORONTO EAST GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Roberta Mackenzie TORONTO EAST GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Tara Macleod TORONTO EAST GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Melanie Ornstein TORONTO EAST GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Perry Phillips TORONTO EAST GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Elin Raymond TORONTO EAST GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Melissa Tai TORONTO EAST GENERAL HOSPITAL Lecturer Part-time OBGYN Dr. Brenda T. Woods TORONTO EAST GENERAL HOSPITAL Assistant Professor Part-time OBGYN Dr. Anne Claessens TORONTO WEST FERTILITY CENTRE Assistant Professor Part-time OBGYN Department of Obstetrics and Gynaecology Faculty of Medicine, University of Toronto

Dr. Dalip Kumar Bhangu TRILLIUM HEALTH CENTRE Lecturer Part-time OBGYN Dr. Veena Bonde TRILLIUM HEALTH CENTRE Lecturer Part-time OBGYN Dr. Catherine Ann Cowal TRILLIUM HEALTH CENTRE Lecturer Part-time OBGYN Dr. Marianne R. Duemler TRILLIUM HEALTH CENTRE Lecturer Part-time OBGYN Dr. Ronnie Hakim TRILLIUM HEALTH CENTRE Lecturer Part-time OBGYN Dr. Patrick M. Liao TRILLIUM HEALTH CENTRE Lecturer Part-time OBGYN Dr. Kendra Newell TRILLIUM HEALTH CENTRE Lecturer Part-time OBGYN Dr. Kristy A. Prouse TRILLIUM HEALTH CENTRE Assistant Professor Part-time OBGYN Dr. Kimberly Rogers TRILLIUM HEALTH CENTRE Lecturer Part-time OBGYN Dr. Peter W. Scheufler TRILLIUM HEALTH CENTRE Lecturer Part-time OBGYN Dr. Richard Stein TRILLIUM HEALTH CENTRE Lecturer Part-time OBGYN Dr. Felice Petraglia UNIVERSITY OF SIENA, ITALY Adjunct Professor Adjunct Professor ( OBGYN Dr. David Caloia UNIVERSITY OF TORONTO Lecturer Part-time OBGYN Dr. Astrid Christoffersen-Deb UNIVERSITY OF TORONTO Lecturer Status-only OBGYN Dr. James Goodwin UNIVERSITY OF TORONTO Associate Professor Status-only OBGYN Dr. Evelyn Lambe UNIVERSITY OF TORONTO Assistant Professor Full-time OBGYN Dr. Katherine MacRury UNIVERSITY OF TORONTO Assistant Professor Full-time OBGYN Dr. Xuesen Dong Vancouver Prostate Centre - UBC Assistant Professor Status-only (Non-MOBGYN Dr. Ari Baratz WOMEN'S COLLEGE HOSPITAL Lecturer Part-time OBGYN Dr. Prati Sharma WOMEN'S COLLEGE HOSPITAL Assistant Professor Part-time OBGYN Dr. Jerry Shime WOMEN'S COLLEGE HOSPITAL Professor Emeritus Professor Emeritus OBGYN Dr. Bruce Thomas WOMEN'S COLLEGE HOSPITAL Assistant Professor Part-time OBGYN 3.1.2 Department of Obstetrics & Gynaecology Cross Appointments

FullNAME LastName HOSPITAL RANK STATUS PRIMARY DEPARTMENT Dr. Lyle Palmer DALLA LANA SCHOOL OF PUBLIC HEALTHProfessor Status-only Dalla Lana Dr. Michelle Letarte HOSPITAL FOR SICK CHILDREN Professor Status-only Immunology Dr. Janet Rossant HOSPITAL FOR SICK CHILDREN Professor Molecular Genetics Dr. Rachel Wald HOSPITAL FOR SICK CHILDREN Assistant Professor Full-time Pediatrics Dr. Rosanna Weksberg HOSPITAL FOR SICK CHILDREN Professor Paediatrics Dr. Jerald Bain MOUNT SINAI HOSPITAL Professor Emeritus Professor Emeritus Medicine Dr. Jose Carvalho MOUNT SINAI HOSPITAL Professor Anaesthesia Dr. David A. Chitayat MOUNT SINAI HOSPITAL Professor Paediatrics Dr. Karen Chong MOUNT SINAI HOSPITAL Assistant Professor Full-time Paediatrics Dr. Joseph T. Clarke MOUNT SINAI HOSPITAL Professor Paediatrics Dr. Terence Colgan MOUNT SINAI HOSPITAL Professor Lab. Medicine and Path. Dr. Jack Marc Colman MOUNT SINAI HOSPITAL Professor Full-time Medicine-Cardiology Dr. Michael Dunn MOUNT SINAI HOSPITAL Associate Professor Paediatrics Dr. Denice Feig MOUNT SINAI HOSPITAL Associate Professor Medicine Dr. Katherine Fong MOUNT SINAI HOSPITAL Associate Professor Medical Imaging Dr. Sarah Keating MOUNT SINAI HOSPITAL Associate Professor Lab. Medicine and Path. Dr. Carl Laskin MOUNT SINAI HOSPITAL Associate Professor Medicine/Immunology Dr. Shoo Lee MOUNT SINAI HOSPITAL Professor Paediatrics Dr. Shia Salem MOUNT SINAI HOSPITAL Associate Professor Medical Imaging Dr. Ants Toi MOUNT SINAI HOSPITAL Professor Medical Imaging Dr. Sandra Viero NORTH YORK GENERAL HOSPITAL Assistant Professor Lab. Medicine and Path. Dr. A.W. Fyles PRINCESS MARGARET HOSPITAL Professor Radiation Oncology Dr. Amit Oza PRINCESS MARGARET HOSPITAL Professor Medicine Dr. William B. Chapman ST. JOSEPH'S HEALTH CENTRE Professor Lab. Medicine and Path. Dr. Tony Barozzino ST. MICHAEL'S HOSPITAL Assistant Professor Paediatrics Dr. Joel Ray ST. MICHAEL'S HOSPITAL Associate Professor Medicine Dr. M. Sgro ST. MICHAEL'S HOSPITAL Assistant Professor Paediatrics Dr. Ida Ackerman SUNNYBROOK HEALTH SCIENCES CENTREAssociate Professor Radiation Oncology Dr. Elizabeth Asztalos SUNNYBROOK HEALTH SCIENCES CENTREAssociate Professor Full-time Pediatrics Dr. Phyllis Glanc SUNNYBROOK HEALTH SCIENCES CENTREAssociate Professor Medical Imaging Dr. Stephen Halpern SUNNYBROOK HEALTH SCIENCES CENTREProfessor Anaesthesia Dr. Stephen Holzapfel SUNNYBROOK HEALTH SCIENCES CENTREAssociate Professor Family & Community Medicine Dr. Anne Kenshole SUNNYBROOK HEALTH SCIENCES CENTREProfessor Emeritus Medicine Dr. Mahmoud Khalifa SUNNYBROOK HEALTH SCIENCES CENTREProfessor Lab. Medicine and Path. Dr. Steven Narod SUNNYBROOK HEALTH SCIENCES CENTREProfessor Public Health Sciences Dr. Andrew T. Shennan SUNNYBROOK HEALTH SCIENCES CENTREAssociate Professor Paediatrics Dr. Martin Skidmore SUNNYBROOK HEALTH SCIENCES CENTREAssistant Professor Paediatrics Dr. Gillian Thomas SUNNYBROOK HEALTH SCIENCES CENTREProfessor Radiation Oncology Dr. Lynn Allen TORONTO GENERAL HOSPITAL - UHN Associate Professor Lab. Medicine and Path. --Clin.Biochem Dr. Denise Belsham TORONTO GENERAL HOSPITAL - UHN Professor Physiology Dr. Gail Robinson TORONTO GENERAL HOSPITAL - UHN Professor Psychiatry Dr. Patricia Shaw TORONTO GENERAL HOSPITAL - UHN Associate Professor Lab. Medicine and Path. Dr. Sam Siu TORONTO GENERAL HOSPITAL - UHN Professor Medicine Dr. Donna Stewart TORONTO GENERAL HOSPITAL - UHN Professor Psychiatry Dr. John Challis UNIVERSITY OF TORONTO Professor Emeritus Professor Emeritus Physiology Dr. Stephen Matthews UNIVERSITY OF TORONTO Professor Physiology Dr. Maire Percy UNIVERSITY OF TORONTO Professor Emerita Professor Emerita Physiology Cyclical Review Fall 2012 Self-Study 13

3.2 Residents 2012-2013

PGY 1 PGY4 Abu Awad, Nasser Campbell, Melanie Coroneos, Marie Ferguson, Brian Gotha, Lara Frecker, Helena Harding, Lacey Gagnon, Louise-Helene Lai, Ingrid Han, Alice Leonardi, Mathew Kfouri, Julia Liao (née Verma), Pamela Mills, Kelsey McCaffrey, Carmen Po, Leslie Mehta, Chaula Sharma, Priya Nguyen, Julie Sovran, Laura Niles, Kirsten Taerk, Evan Sarangapani, Aparna Sterling, Lynn

PGY2 PGY5 Green, Jessica Backman, Stephanie Gurau, David Bouchard-Fortier, Genevieve Habiba, Ummi Caprara, Daniela Li, Adrienne Chan, Crystal Menzies, Rebecca Iqbal, Salikah Noack, Laura Jumah, Naana Rich, Rebecca Kandasamy, Tharani Secter, Michael Khoshbakht, Noushin Shea, Alison Moore, Shannon Simpson, Andrea Oyewumi, Lamide Snelgrove, John Qin, Jing Tan, Liane Shirreff, Lindsay Thorne, Julie

PGY3 Baker, Emily Bremer, Kimberly Chan, Caroline Cipolla, Amanda Cybulska, Paulina Jolliffe, Courtney Lennox, Genevieve Liu, Brian Mayo, Karli Millar, Heather Morris, Stephen Yusuf, Muhseen

Cyclical Review Fall 2012 Self-Study 14

3.3 Fellows 2012-13 3.3.1 Fellows by Alphabetical Order (as of Jul 21 2012)

Fellow/Resident Fellowship Program Site Director 1. Adanlawo, Moses ClinFell MFM MSH Maxwell 2. Ahmadouh, Hend ClinFell RepBiology TCART Casper 3. Al-Anjari, Abdulmohsen PGY6 & 7 MFM MSH Maxwell 4. Al-Gethami, Faiza ClinFell MatureWH&M MSH Wolfman 5. Al-Hawash, Shadha ClinFell AdvObs MSH Seaward 6. Al-Kudmani, Basheer ClinFell AdvOB SHSC Hui 7. Al-Obaidly, Sawsan ClinFell MFM MSH Maxwell 8. Ang, Miriam ClinFell MIGS SHSC Kung 9. Bamanie, Elham ClinFell Urogynaecology MSH Lovatsis 10. Behan, Lucy ClinFell ReproSci TCART Casper 11. BOUTET, Marianne ClinFell Gyne Surgery SMH Lefebvre 12. Czikk, Marie PGY6 & 7 MFM MSH Maxwell 13. Daniel, Ariadne PGY6 & 7 GREI MSH Cruickshank 14. Reproductive Create / Dar, Shir ClinFell Sciences SHSC/WCH Librach 15. DAWOOD, Ashraf ClinFell Gyne Endoscopy SJHC Ternamian 16. Diamond, Phaedra ClinFell Urogyne & RPS MSH Lovatsis 17. Drai-Hassid, Revital ClinFell AdvObs SHSC Hui 18. D'Souza, Rohan ClinFell MFM MSH Maxwell 19. Dubuc, Elise ClinFell PAG HSK Kives 20. El-Chaar, Darine PGY6,7 MFM MSH Maxwell 21. PGY 6 & 7/ Eriksson, Lua ClinFell GynOnc SHSC/PMH Covens 22. Evaniuk, Debra ClinFell MatureWH&M MSH Wolfman 23. Feigenberg, Tomer ClinFell GynOnc SHSC/PMH Covens 24. Garbedian, Kimberley PGY6 & 7 GREI MSH Cruickshank 25. Gomaa, Hala ClinFell Repro Sciences TCART/MSH Casper 26. Hackmon, Rinat ClinFell MFM MSH Maxwell 27. Hassonah, Seham ClinFell Urogyne & RPS MSH Lovatsis 28. Higgins, Mary ClinFell MFM MSH Maxwell 29. Hodges, Ryan ClinFell MFM MSH Maxwell 30. Horgan, Richard ClinFell MFM MSH Maxwell 31. Hunter, Tiffany ClinFell MFM MSH Maxwell 32. Ibrahim, John N ClinFell AdvObs MSH Seaward 33. Jones, Claire PGY6,7 GREI MSH Cruickshank 34. LAZER, Tal ClinFell ReproSci CReATe Librach 35. Leong, Yvonne ClinFell UroGyne&Re MSH Lovatsis 36. Kung, Bodley, LO, Katherine ClinFell Urogynaecology SHSC & WCH Lee 37. McVey, Ruaidhri ClinFell GyneOnc SHSC Covens Cyclical Review Fall 2012 Self-Study 15

3.3.1 Fellows 2012-13 by Alpha (as of Jul 21 2012)…continued

38. Medel, Sebastian ClinFell Urogyne & RPS MSH Lovatsis 39. Melamed, Nir ClinFell AdvHRObs SMH HSC Berger 40. Mitri, Frederick ClinFell ReproSci TCART Casper 41. Morency, Anne-Maude PGY6,7 MFM MSH Maxwell 42. Paterson, Nicole PGY6,7 GREI MSH Cruickshank 43. Qadri, Anita ClinFell GynOnc UHN Rosen etc 44. READE, Clare CF; PG 6,7 GyneOnc SHSC Covens 45. Robinson, Na Tisha ClinFell MFM MSH Maxwell 46. Segev, Yakir ClinFell GyneOnc SHSC Covens 47. Shore, Eliane ClinFell MIGS SMH Lefebvre 48. SOHN, Brenda ClinFell Gyne Endoscopy SJHC Ternamian 49. SINASAC, Sarah CF; PG 6,7 GyneOnc SHSC Covens 50. Talukdar, Nayana ClinFell Repro Sciences TCART Casper 51. Tremblay, Catherine ClinFell Gyne Surgery SMH Lefebvre 52. Van Mieghem, Tim ClinFell MFM MSH Maxwell 53. Weintraub, Amir ClinFell ReproSci TCART Casper 54. Zebede, Saloman ClinFell UroGyne&Re MSH Lovatsis

3.3.2 Fellows by Program (as of Jul 21 2012)

Fellow/Resident Fellowship Program Site Director 1. Melamed, Nir ClinFell AdvHRObs SMH HSC Berger 2. Al-Hawash, Shadha ClinFell AdvObs MSH Seaward 3. Ibrahim, John N ClinFell AdvObs MSH Seaward 4. Al-Kudmani, Basheer ClinFell AdvOB SHSC Hui 5. Drai-Hassid, Revital ClinFell AdvObs SHSC Hui 6. Daniel, Ariadne PGY6 & 7 GREI MSH Cruickshank 7. Garbedian, Kimberley PGY6 & 7 GREI MSH Cruickshank 8. Jones, Claire PGY6,7 GREI MSH Cruickshank 9. Paterson, Nicole PGY6,7 GREI MSH Cruickshank 10. DAWOOD, Ashraf ClinFell Gyne Endoscopy SJHC Ternamian 11. SOHN, Brenda ClinFell Gyne Endoscopy SJHC Ternamian 12. BOUTET, Marianne ClinFell Gyne Surgery SMH Lefebvre 13. Tremblay, Catherine ClinFell Gyne Surgery SMH Lefebvre 14. McVey, Ruaidhri ClinFell GyneOnc SHSC Covens 15. READE, Clare CF; PG 6,7 GyneOnc SHSC Covens 16. Segev, Yakir ClinFell GyneOnc SHSC Covens 17. SINASAC, Sarah CF; PG 6,7 GyneOnc SHSC Covens 18. PGY 6 & 7/ Eriksson, Lua ClinFell GynOnc SHSC/PMH Covens 19. Feigenberg, Tomer ClinFell GynOnc SHSC/PMH Covens Cyclical Review Fall 2012 Self-Study 16

20. Qadri, Anita ClinFell GynOnc UHN Rosen etc 21. Al-Gethami, Faiza ClinFell MatureWH&M MSH Wolfman 22. Evaniuk, Debra ClinFell MatureWH&M MSH Wolfman 23. Adanlawo, Moses ClinFell MFM MSH Maxwell 24. Al-Anjari, Abdulmohsen PGY6 & 7 MFM MSH Maxwell 25. Al-Obaidly, Sawsan ClinFell MFM MSH Maxwell 26. Czikk, Marie PGY6 & 7 MFM MSH Maxwell 27. D'Souza, Rohan ClinFell MFM MSH Maxwell 28. El-Chaar, Darine PGY6,7 MFM MSH Maxwell 29. Hackmon, Rinat ClinFell MFM MSH Maxwell 30. Higgins, Mary ClinFell MFM MSH Maxwell 31. Hodges, Ryan ClinFell MFM MSH Maxwell 32. Horgan, Richard ClinFell MFM MSH Maxwell 33. Hunter, Tiffany ClinFell MFM MSH Maxwell 34. Morency, Anne-Maude PGY6,7 MFM MSH Maxwell 35. Robinson, Na Tisha ClinFell MFM MSH Maxwell 36. Van Mieghem, Tim ClinFell MFM MSH Maxwell 37. Ang, Miriam ClinFell MIGS SHSC Kung 38. Shore, Eliane ClinFell MIGS SMH Lefebvre 39. Dubuc, Elise ClinFell PAG HSK Kives 40. LAZER, Tal ClinFell ReproSci CReATe Librach 41. Create / Dar, Shir ClinFell ReproSci SHSC/WCH Librach 42. Ahmadouh, Hend ClinFell RepBiology TCART Casper 43. Talukdar, Nayana ClinFell ReproSci TCART Casper 44. Behan, Lucy ClinFell ReproSci TCART Casper 45. Mitri, Frederick ClinFell ReproSci TCART Casper 46. Weintraub, Amir ClinFell ReproSci TCART Casper 47. Gomaa, Hala ClinFell ReproSci TCART/MSH Casper 48. Bamanie, Elham ClinFell Urogynaecology MSH Lovatsis 49. Diamond, Phaedra ClinFell Urogyne & RPS MSH Lovatsis 50. Hassonah, Seham ClinFell Urogyne & RPS MSH Lovatsis 51. Medel, Sebastian ClinFell Urogyne & RPS MSH Lovatsis 52. Leong, Yvonne ClinFell UroGyne&Re MSH Lovatsis 53. Zebede, Saloman ClinFell UroGyne&Re MSH Lovatsis 54. Kung, Bodley, LO, Katherine ClinFell Urogynaecology SHSC & WCH Lee

Cyclical Review Fall 2012 Self-Study 17

4.1. Undergraduate Education Filomena Meffe, MD, FRCSC , MSc; Undergraduate Medical Education Director July 16, 2012

Description of Clerkship:

The Obstetrics & Gynaecology Clerkship Rotation is six weeks in length. Approximately two weeks are spent in ambulatory care with attendance at prenatal and gynaecology clinics, two weeks in the labour and delivery and postpartum units, and two weeks in a combination of inpatient gynaecology, operating room, emergency room consultations and specialty clinics, depending on the site.

There are four main teaching sites: North York General Hospital, Sunnybrook Health Sciences Centre, St. Michael’s Hospital, and Mount Sinai Hospital. Details of rotations at each of teaching sites are provided in Appendix 4.1.1, which also describes how students are assigned to sites. In addition to these main sites, some students may spend a portion of their rotations (up to two weeks) at other sites, including Toronto East General Hospital, St. Joseph’s Health Centre, Credit Valley Hospital and Trillium Health Centre, and Princess Margaret Hospital.

Students also participate in overnight on-call duties with an average on-call frequency of 1 night in 5 to 1 in 6. While on-call, they attend the labour and birth suite, take part in emergency room consultations and any emergency gynaecologic surgery, and attend to other inpatient issues.

Consistency and equivalency amongst sites is maintained, as all students must rotate through the core clinical components: ambulatory care, inpatient gynaecology and inpatient obstetrics. The clinical problems and procedures that students need to experience, as specified by the objectives of the Obstetrics & Gynaecology Clerkship, as well as the T-Res encounters and procedures log, are attainable at all sites. High-risk obstetrics, gynaecologic oncology and gynaecologic urology are all available for students’ experience at all four core sites.

Notwithstanding, differences in practice patterns do exist among the sites, so that it is important to monitor student feedback on course evaluations regarding their experiences. The majority of students report a positive experience with exposure to a wide variety of clinical problems in both obstetrics and gynaecology at all sites.

Overview of Objectives:

The clerkship objectives were derived using a combination of sources and methods. Heavy emphasis was placed on the CanMEDS roles, which were further informed by the Medical Council of Canada objectives, the Association of Academic Professionals in Obstetrics and Gynaecology (APOG) medical student objectives, and the APGO (American) Women’s Health Objectives. The objectives were first reviewed and agreed upon by the Undergraduate Cyclical Review Fall 2012 Self-Study 18

Medical Education (UME) Committee in Obstetrics and Gynaecology and then by the UME Curriculum Committee.

The objectives are provided on the course website. As well, students receive a hard copy of the course syllabus on the first day of the rotation; the syllabus contains a list of the seminar objectives and a handout for each of the 23 small group seminars given during the six weeks of the rotation. The curriculum directory entry for the OBS310Y course states all the rotation objectives categorized by CanMEDS roles, as well as the specific objectives for technical procedures and skills. Familiarity with these objectives is further reinforced by the student’s use of the daily clerkship encounter form, which lists all the corresponding CanMEDS roles with descriptors and the evaluation criteria.

Below, the objectives are described, firstly, within the overall CanMEDS framework, secondly, as they pertain to the specific learning environment, thirdly, as educational core objectives of procedures and problems, and fourthly, as the TRES list of mandatory encounters.

I. With respect to all the general competencies within the CanMEDS framework, the medical student should achieve the following (see Appendix 4.1.2 for detailed list):

A. General Competencies: 1. Medical Expert/Skilled Clinical Decision Maker: Demonstrate the ability to assess and manage common and important problems which women will present within the discipline of Obstetrics and Gynaecology and demonstrate competency in pelvic examination and other basic procedural skills relevant to the discipline of obstetrics and gynaecology. 2. Communicator/Doctor-Patient Relationship: Communicate effectively and empathetically with patients and their families during all clinical encounters (history- taking, obtain appropriate consent during procedures and examinations) and document thoroughly. 3. Collaborator: Establish and maintain effective working relationship with colleagues and other healthcare professionals, understand triaging and prioritization of care, and demonstrate knowledge of resources available to women. 4. Manager: Demonstrate appropriate and cost-effective use of investigations and treatments and develop an understanding of the factors contributing to resource issues in outpatient prenatal and gynaecology clinics, in-hospital labour and birth and postpartum units, and inpatient gynaecologic and peri-operative services. 5. Health Advocate: Respond to the individual woman’s health care needs and issues as part of patient care, as well as needs of the community, identify the determinants of health and understand methods to promote the health of individual women, communities and populations. 6. Scholar: Access and critically appraise the literature relevant to obstetrics and gynaecology care and understand the many unique learning and teaching opportunities available in Obstetrics and Gynaecology 7. Professional: Attend scheduled and assigned teaching and clinical responsibilities and communicate absences with educational administrators and clinicians in a timely fashion. Cyclical Review Fall 2012 Self-Study 19

Know when to ask for help. Protect information provided by or about patients, keeping it confidential, and divulge it only with the patient’s permission except when otherwise required by law.

II. Clerkship objectives are also provided for the various learning environments:

1. Ambulatory Care in Obstetrics and Gynaecology: Learning Objectives 2. Labour and Delivery Unit: Clinical Learning Objectives 3. Inpatient Gynaecology: Clinical Learning Objectives 4. Pelvic Exam Objectives and Pelvic Exam Policy 5. Basic Science in Obstetrics and Gynaecology: Learning Objectives 6. Seminar Objectives

III. Educational Core Objectives

2. Problem-Based Encounters By the end of the Obstetrics and Gynaecology Clerkship rotation, the student should be able to demonstrate an approach (including differential diagnosis, investigation and initial treatment) to women presenting for antenatal care, intrapartum care, gynaecological consultation (outpatient, inpatient, emergency room), and gynaecologic surgery, based on real or simulated encounters associated with the following issues:

1. Abnormal vaginal bleeding 2. Adnexal /pelvic masses 3. Bleeding and/or pain in pregnancy (>20 wks) 4. Contraceptive methods 5. Fetal wellbeing 6. First or early second trimester complications (<20 wks) 7. Genital tract infections 8. Hypertension in pregnancy 9. Irregular, infrequent or no periods 10. Labour progress Cyclical Review Fall 2012 Self-Study 20

11. Abnormal pap test counseling 12. Pelvic pain 13. Postpartum complications 14. Sexual history

IV.TRES Mandatory Encounters:

The T-Res logging program contains a list of clinical problems which students must encounter and a list of technical procedures/skills which they must perform during the course of the six weeks. This listing reflects the educational core objectives listed above but is more concise and further reminds students of the essential knowledge and skills they are expected to acquire. Students receive further information about objectives at orientation day on the first day of the rotation. Students use T-Res to keep track of their clinical encounters and procedures as well as the level of involvement in those procedures. A paper log of defined cases and procedures is also available if students prefer to maintain the paper log (see Appendix 4.1.3) during the day and then enter their encounters to T-Res at the end of the day. Students must meet with their assigned mentor or site clerkship coordinator at an assigned date and time at mid-rotation to review both their general progress in the rotation thus far and their T-Res Form 062, which lists the encounters they have seen and procedures in which they have participated.

Consensus, experience and knowledge of other programs across Canada allowed the members of the Obstetrics and Gynaecology Undergraduate Medical Education Committee to agree on a list of common procedural skills that students should be able to perform by the end of the six weeks.

Once the common clinical conditions and basic procedural skills were defined, it was evident that a broad range of clinical settings would be required to meet the objectives and these included outpatient obstetrical and gynaecological clinics, labour and birth suites, inpatient gynaecology and operating room participation, on-call opportunities and emergency room settings. The obstetrics and gynaecology clerkship rotation has always had these settings as significant components of the six-week program and clinical volume and variety have always been a great strength of our program.

The proposed list of encounters and procedures was then reviewed with the Deputy Clerkship Director and the Clerkship Director, and then also with the entire Clerkship Committee, before final approval.

Teaching Methods and Formats (Delivery):

Orientation: All sites provide orientation for the medical students on the first day of the rotation. Within the second or third day of the rotation, the students also receive pelvic examination teaching, including a video review and practice on pelvic models.

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Standardized Seminar Program (See Appendix 4.1.4): The Obstetrics & Gynaecology clerkship delivers 23 one-hour small group seminars (most of which are problem-based, discussion format, but some are lecture style with question and answer opportunities) at each of the four major teaching sites: St. Michael’s Hospital, North York General Hospital, Mount Sinai Hospital, and Sunnybrook Health Sciences Centre. The seminars are designed to provide students with the knowledge and approach to address clinical problems to achieve the course objectives. Based on the basic knowledge objectives established through a review of objectives from the above-mentioned national organizations, a list of 23 seminar topics was chosen to capture the common clinical conditions within the discipline of obstetrics and gynaecology. Using the seminar topics as a guide, a list of common problems was then generated by consensus of the members of the Obstetrics and Gynaecology Undergraduate Medical Education Committee. This was cross-referenced to the curricular content and objectives of the Mechanisms, Manifestations and Management of Disease (MMMD) course (previously Foundations of Medical Practice) in the second-year medical school program to ensure that there was both continuity and further development of problem-solving skills moving from second year to third year. Discussions occurred with the section head of the three weeks in the MMMD program related to women’s health in order to ensure that the objectives of the course were being expanded on, both in depth and breadth, in the clerkship year. The section head for these three weeks is also the site clerkship coordinator at Mount Sinai Hospital and sits on the Obstetrics and Gynaecology Undergraduate Medical Education Committee.

All sites disperse the seminars throughout the six-week rotation, with one generally being given during each weekday. The timing may vary from site to site depending on the clinical activities of the faculty members at that site. For students who attend the Mississauga sites for clinical rotations, the seminars are videoconferenced from Mount Sinai Hospital to the Credit Valley Hospital and from St. Michael’s Hospital to the Trillium Health Centre. For students who are assigned to a subrotation at St. Joseph’s Hospital or Toronto East General Hospital, they first attend the seminars at their primary hospital site, either St. Michael’s Hospital or Mount Sinai Hospital, and then travel to their subrotation site for their clinical assignments. The ease of travelling by TTC and travel time of 30-40 minutes allows for students to arrive at their subrotation site in a timely fashion. There are plans to implement videoconferencing of the seminar program to both Toronto East General and St. Joseph’s Health Centre in order to further minimize travel.

Other Teaching Resources: The clerkship syllabus is provided electronically on the course website. In addition, we have provided videos and objectives for pelvic examination teaching (New England Journal of Medicine Pelvic Exam Video and the Queen’s University Comprehensive Female Pelvic Examination). Students may also access a Multiple Choice Self-Testing module from the Association of Academic Professionals in Obstetrics and Gynaecology online. A link to the Society of Obstetricians and Gynaecologists of Canada (SOGC) website has also been provided on the course website so students can access links to clinical practice guidelines. Audio recordings of a majority of the seminar topics are also available on the course website. These recordings were made to provide students with the means to access teaching electronically if they were not attending the seminars in person. Cyclical Review Fall 2012 Self-Study 22

Midrotation Feedback: Currently, the site coordinator or student mentor meets with the student at the midpoint of the rotation to review both their general progress in the rotation thus far and their T-Res 062 form which lists the problems they have seen and procedures in which they have participated. In addition to reviewing T-Res Form 062 at mid-rotation, the mentor and/or site clerkship co- coordinator must also review the Obstetrics and Gynaecology mid-rotation feedback form (See Appendix 4.1.5) with the student and then complete this form on MedSIS (Medical Student Information System) soon after their meeting. Students are given feedback about their strengths and areas that require further work. If necessary, the site coordinator or mentor will re-configure the student’s clinical activities in the remaining three weeks to ensure that the course objectives are met. By the fourth week of the rotation, the course director reviews the status of the mid-rotation feedback for (complete/incomplete) on MedSIS and the T-Res 062 form (on the T-Res website) for every student in the block. If there are any incomplete mid-rotation feedback forms and/or inadequate progress on the T-Res 062 form, the course director will:

1. Notify the site supervisor or student mentor to remind them to meet with the student if they have not yet done so and to complete the mid-rotation feedback form. 2. Notify the students, as well as their mentors and/or site supervisors, that a plan will be required to ensure that all objectives are met in the remaining 2 weeks of the rotation.

In extreme cases, if the lack of progress was considered serious enough that the student’s ability to pass the course was in jeopardy and/or there was concern about the student’s wellbeing, the course director would be notified immediately and, if necessary, the Clerkship Director and/or Associate Dean, Health Professions Student Affairs would also be involved..

At the end of the rotation, students meet again with the site coordinator or mentor to review the T-Res report 064 and review the final ward/clinical evaluation form. Any students with an incomplete T-Res 064 form are brought to the attention of the Course Director immediately. Also, students are informed to email the T-Res 064 report directly to the Course Director and Undergraduate Administrative Coordinator for Obstetrics and Gynaecology in addition to bringing this form to the end of rotation exit interview with their site coordinator or mentor. This is to ensure that any incomplete T-Res 064 forms are reviewed by the Course Director as soon as possible. Students with incomplete T-Res 064 forms must meet with both the site coordinator and Course Director to devise and implement a plan to complete the required encounters and procedures in a timely fashion. Incomplete encounters are addressed through assignment of a clinical problem to work through and incomplete procedures are addressed either through a simulation or by scheduling more clinical time to complete the procedure(s). The undergraduate program has specified that all students must complete all the required encounters and procedures by six weeks after the end of year 3.

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Methods for Assessing Student Performance

Clerkship Clinical Encounter Forms (See Appendix 4.1.6) Students must collect ten clerkship encounter forms during the course of their six-week rotation in Obstetrics & Gynaecology, which are then compiled to complete the final ward evaluation form (worth one third of the final mark). The final ward mark will be incomplete if students do not have ten forms. This rule applies to every student at every site. The clerkship encounter form is based on the final ward evaluation form with regard to the CanMEDs roles and several competencies (listed below), and can be graded from a range of “unsatisfactory” to “outstanding” as well as a category for “not assessed”. Descriptors for each category are provided. These include several competencies related to core clinical skills. The student is expected to ask the supervisor at the end of a meaningful clinical encounter to complete the form, which then is sent to the site coordinator or mentor responsible for completing the student’s final evaluation. It is not always possible to evaluate every item on the form for every particular clinical encounter.

The supervisor is able to assess the student with regard to knowledge, skills and attitudes through direct observation (which is mandatory for pelvic examination), student oral reporting, verbal discussion, and review of dictated or written materials generated by the student. History-taking skills, oral presentation skills, pelvic examination skills, quality of written reports, clinical judgment, test interpretation, communication skills, collaboration skills, health advocacy skills, manager skills and demonstration of scholarly attitudes can be assessed. Faculty members have been instructed to complete the clerkship encounter form with the student present and to provide both written and verbal feedback at the end of the encounter.

Mandatory Observation of History-Taking and Pelvic Examination

Also, in response to the findings on the Canadian Graduation Questionnaire that history- taking by medical students is not observed as often as it ought to be during this rotation, a mandatory teacher-observed history-taking session has been implemented since May 2012. It has always been mandatory that medical students be supervised during a pelvic examination session, with overall performance being recorded on the clerkship encounter form. However, now with the additional implementation of a mandatory observation of history-taking, a new evaluation form has been designed for both observed history-taking and pelvic examination (See Appendix 4.1.7). This form was pilot-tested in the February-March 2012 block and finalized in May 2012. This newly-introduced evaluation measure has been reviewed and discussed at the Business Meetings of all sites and both faculty members and students have been orientated with regard to its use.

Final Examination: The final examination contributes two thirds to the final mark for the course and includes:

1. a written component (worth 1/3 of final mark) Cyclical Review Fall 2012 Self-Study 24

a. 30-question short answer component, b. 20-question multiple choice component and 2. a structured oral examination (worth 1/3 of final mark) a. 2 questions based on obstetrical problems, b. 2 questions based on gynaecological problems.

Both examinations are conducted at each of the 4 primary teaching sites on the same day and similar timing. The structured oral examination is focused on evaluating core clinical skills related to the course. The questions are structured in that there is a standard scenario presented to the student, followed by specific questions for the student to answer. Clinical information is provided at key points of the oral examination for the student to interpret and evaluate as they develop a working diagnosis and management plan.

Integrated OSCE The integrated OSCE was first introduced in the third year clerkship in 2010-11, with two OSCE examinations: one at the end of 24 weeks, and the other at the end of 48 weeks. Both examinations contain materials related to obstetrics and gynaecology content. Final Assessment: The final assessment is based on 3 components that are all worth one third of the final mark: 1. written examination (short answer questions: 30 total; MCQs 20 total) 2. structured oral examination (2 obstetrical questions, 2 gynaecology questions) 3. final ward assessment The Mandatory Observed History and Pelvic Examination form must be submitted and all TRES objectives must be completed in order to successfully complete the course but these items are not graded. Students must obtain 60% or greater on each of the three components, written exam, oral exam and ward assessment, in order to pass the course. If a student obtains less than 60% on any of these three components, they have failed the course and remediation procedures, according to the Undergraduate Medical Education Program policy, will be put in place. Any student scoring between 60-70% on any of the three components will be assigned extra work by the course director. The extra work must be completed successfully to obtain credit in the course.

Awards:

Faculty: A total of 7 yearly undergraduate awards for teaching excellence are given out to faculty members based on teaching effectiveness scores and written comments by students. One yearly Chair’s Award for Sustained Excellence in Undergraduate Teaching is given to a faculty member who has demonstrated consistent and sustained excellence in undergraduate teaching in their first 10 years as a faculty member.

Students: Four undergraduate awards are given out to four final year students: Dr. Jacob Goldstein Scholarship in Obstetrics and Gynecology Hendry Memorial Scholarship Dr. Frederick R. Papsin Award Dr. Sidney M. Roselyn Tobin Compassionate Scholarship in Obstetrics and Gynecology Cyclical Review Fall 2012 Self-Study 25

Residents: There are plans, in collaboration with the Postgraduate Director, to create an undergraduate teaching award for residents which will be based on the resident’s teaching effectiveness scores and any written comments by students.

Funding: The position of Undergraduate Director and Undergraduate Coordinator are funded by the Department of Obstetrics and Gynaecology.

Quality Indicators:

The student course evaluation data, both numerical and written feedback, are the primary source for analyzing the quality of the course. Data from faculty evaluations, seminar evaluations, and the Canadian Graduate Student Questionnaire are also taken into consideration.

The analysis below is based on course evaluation data from 2009-10 and 2010-11. The 2011- 2012 data are not yet available, as the academic year will be completed on August 31, 2012 and complete data will not be available until mid October 2012. See Appendix 4.1.8 for Tables on Course Evaluation Data 2009-2010 & 2010-2011

Percentage of students providing evaluation data: 2010-2011: 196 / 224 = 88% 2009-2010: 207 / 225 = 92%

Key findings include the following:

1. The ratings of the quality of the rotation as a whole and its components were done using a scale of 1 = poor, 2 = fair, 3 = satisfactory, 4 = very good and 5 = excellent.

a) The ratings of the rotation as a whole averaged 4.0 in 2009-10, and 3.8 in 2010- 11. (Only 3.4% rated the rotation as fair or poor in 2009-10, and 5.1% in 2010- 11.)

b) In both years, several of the elements of the rotation were rated quite high (4.0 or higher): formal seminars (program coverage and syllabus), learning objectives (for seminars, ambulatory care, and labour and delivery), and informal teaching (office, labour and delivery). The elements that were rated relatively lower but still satisfactory were teaching during ward rounds (3.4 – 3.5) and in the operating room (3.4 both years).

2. The experiential aspects of the rotation were rated using a scale of 1 = strongly disagree, 3 = neutral, and 5 = strongly agree. A total of 14 aspects were rated, and in both years nine of them were rated 4.0 or higher, and all of them were at least 3.5. The obstetrical experience, in particular, was rated positively: Cyclical Review Fall 2012 Self-Study 26

 having an adequate number of obstetric patient experiences had an agreement mean score of 4.4 in both years;  they were encouraged to follow patients in labour (4.3 and 4.2), and  they felt they had the opportunity for hands-on experience in labour and delivery (4.3 and 4.0) and  when asked in 2010-11, they agreed they were called for deliveries (4.1).

Ambulatory clinic opportunities were rated quite highly (score of 4.0 in both years); and there was good discussion of patients who had been assessed (4.4 in both years). Scores related to having an adequate number of gynaecology patients (3.4 and 3.6), involvement in the operating room (3.6 and 3.8), and in the emergency room (3.8 in 2010-11) were slightly lower but still satisfactory.

They agreed the balance of training and service was appropriate (4.1 and 4.0), and they felt quite well accepted on the team (3.9 and 3.8). Their ratings of being made to feel part of the team by the nurses were between 3.5 and 3.6, and getting instruction from the nurses that augmented their skill averaged 3.5 and 3.6.

Strengths:

1. Seminar Program – The seminar program is highly valued by the medical students based on their written feedback and numerical ratings. Medical students report that the program is well-integrated into the rotation and well-structured. The overwhelming majority of students prefer having one daily seminar spread out over the course of the six-week rotation rather than several seminars per day given over a few days at the beginning of the rotation. The existing system allows them to review smaller amounts of material at a constant pace. Students report that many seminars were informal, engaging, and encouraged participation, which was a more effective learning environment for them when compared to lecture-style seminars. Students reported that seminars were well- prepared and delivered with highly relevant topics that allow them to learn something every day. A much smaller number of students indicated that they would prefer receiving all the seminars within the first week of the rotation.

2. Excellent faculty teaching: Students have reported that the majority of faculty members are excellent to work with, they encourage students to improve their skills in a safe environment, they are eager and enthusiastic to teach, and are “stellar” at teaching and mentoring. They report an excellent ratio of staff to students in the majority of cases.

3. Excellent resident teaching: The residents have been described as “amazing” in their teaching. They are described as eager to teach, knowledgeable, helpful, friendly, invaluable, excellent to work with, willing to answer questions and able to create a good learning environment.

4. Great diversity and variety in patient problems and procedures

5. Students report sufficient “hands-on” experience in most clinical areas Cyclical Review Fall 2012 Self-Study 27

6. Successful transition from Gynaecologic Teaching Patient program to pelvic model teaching and videos.

7. Successful implementation of mandatory mid-rotation feedback session for all students, with participation reaching 100%.

8. Involvement of community-affiliated sites in the clerkship teaching

9. Organization and implementation of a two-week Mississauga clinical rotation with videoconferencing of seminars from both Mount Sinai Hospital and St. Michael’s Hospital to Credit Valley Hospital and Trillium Health Centre, respectively. This initiative was started as a pilot project in 2010-11 with eight students (four from each of two blocks). In the year 2011-12, four students in each of the six blocks participated in the two-week Mississauga clinical assignment. Preliminary feedback from faculty members and students has been very positive thus far. For the year 2012-13, a total of 8 students will be participating in the 2-week Mississauga clinical subrotation, with 4 students assigned during weeks 2 and 3 and another 4 students assigned during weeks 4 and 5. Plans are already underway to secure 4 weeks of videoconferencing resources so that transmission of the videoconferencing between Mount Sinai to Credit Valley and St. Michael’s to Trillium may continue.

Quality Enhancement:

1. Although students rated the course syllabus as being “satisfactory” to “very good”, with some very positive written feedback (“the syllabus is an excellent resource”, “the notes were referred to during studying”, “the topics were useful”), there were still individual comments from students that the course syllabus was too long and too detailed, with too much variation in formatting, making it difficult to read and follow. In some handouts, the information seems outdated. The clerkship syllabus was reformatted and information updated for the academic year 2010-11 and the process was repeated again for 2011-12. For the academic year 2012-13, the student representatives, as well as the authors of the chapters, will review the syllabus for further updates;

2. About 45-50% of students had visited the course website, according to data collected from the final clerkship evaluation form. Some students commented that they did not find the website useful, some of the information was described as outdated or they did not need to access it because they were receiving the same information in hard copy. More educational resources and links have already been added to the course website, which should make the website more relevant and useful to the students. A standardized and simplified structure for all clerkship course websites was implemented for 2010-11 and this has helped improve the organization of the information.

3. Involving students in the operating room and inpatient gynaecology in an educationally effective manner still remains a challenge due to the trend towards minimally invasive interventions, increased percentage of surgical day care cases and decreased length of stay for inpatients. The Obstetrics & Gynaecology Undergraduate Committee members Cyclical Review Fall 2012 Self-Study 28

(including student and resident representatives) have discussed ways to improve student engagement in the operating room and inpatient gynaecology activities. As well, the Course Director has recently met separately with the medical student representatives on the Obstetrics and Gynaecology Undergraduate Committee to discuss possible ways to enhance student learning. Student representatives have indicated that (1) linking gynaecology clinic activities and emergency room consultations with attendance in the operating room during the same week would help students improve their understanding of the process of surgical decision-making in gynaecological problems, and (2) having students do minor procedures (urinary catheter insertions, skin suturing for laparoscopic ports, pelvic examination under anaesthesia (with patient consent) would help engage students further. The student representatives have agreed to poll their classmates for further ideas. This information will be presented at an upcoming Undergraduate Committee meeting for further discussion and development of an action plan.

4. There is the potential in some settings for there to be an excessive number of learners (students and residents together) and also the potential for students to have less meaningful responsibility for patient care. This has been noted in some comments on the Canadian Graduation Questionnaire feedback, and also on the Independent Student Analysis for the Accreditation (ISA). Among the year 3 students, a relatively low proportion of students (64.1%) agreed or strongly agreed that they had meaningful responsibility for patient care on the Obstetrics & Gynaecology rotation, while among year 4 students, 74.6% (reflecting on their year 3 rotation) agreed or strongly agreed. The Course Director and course committee are aware of these findings. It is noteworthy that on internal course evaluations, students report on average a very good level of involvement in the care of patients in labour, as summarized in the quantitative data above. It appears that the likely reason for the relatively lower proportion of students feeling an adequate level of involvement relates to the issues identified immediately above; i.e., a lower level of involvement in the operating room, ward and, possibly, emergency room. The course committee will carefully review this issue during 2011-12, and particularly scrutinize feedback from the new learning environment survey that includes specific questions about the degree to which students perceive themselves to be meaningfully involved in patient care. This will permit the committee to identify any patterns where the level of involvement is especially low, for instance at a particular site, and facilitate intervention. Student representatives’ input will also be sought. As well, site coordinators will be discussing these issues with faculty members in their departments at Business meetings to increase awareness and provide tips on how to involve students more in clinical care.

5. Students rate their agreement with the statement that “nurses make them feel like part of the team” and “help them augment their skills” between “neutral” and “agree”. Individual comments from students occasionally describe difficulty in accessing clinical experiences in the labour and delivery unit because of tensions with the nursing staff. However, many students describe very positive interactions with nursing staff and valuable interprofessional learning. The Obstetrics & Gynaecology site directors will continue to work hard to ensure that nursing administrators and educators remain Cyclical Review Fall 2012 Self-Study 29

sensitive to medical student learning needs and orientate their staff to the medical students’ objectives. Some sites have incorporated nurses as mentors to medical students in the labour and birth department, which has proven to be a useful process.

6. After eliminating the use of standardized patients to teach the pelvic examination during third year clerkship, pelvic models and videos were introduced. All students receive orientation on pelvic examination using the models and have access to the Queen’s University video on this subject, produced by Dr. Robert Reid. Some students find the pelvic models stiff and unrealistic but realize that it is important to practice on the models prior to seeing patients in the clinics. Other students find the orientation somewhat repetitive because they receive a similar orientation during their Family & Community Medicine clerkship rotation, and on four of the six blocks students have completed their Family & Community Medicine clerkship rotation before they come to the Obstetrics & Gynaecology clerkship. After much consideration of this issue, a decision was made to continue with the pelvic examination orientation. Many students have commented that repetition is important with regard to pelvic examination teaching, especially since there is no practical pelvic examination teaching in the Preclerkship. Also, opportunities to perform pelvic examinations on patients during the Family & Community Medicine clerkship is variable, depending on who the student’s preceptor is, whereas in the Obstetrics & Gynaecology clerkship, it is the main physical examination component of outpatient and inpatient encounters.

7. Some male medical students have reported that it is more difficult for them to get permission from patients to be involved in their care, especially with regard to performing pelvic examinations. For some patients, there are religious and/or cultural reasons for declining male medical student involvement. We have made an attempt to pair male medical students with male faculty members to improve patient acceptance. The Chair has sent a notice to each Obstetrician and Gynaecologist-in-Chief explaining that it has come to his attention that male medical students may be at a disadvantage compared with their female colleagues with respect to performing pelvic examination during their clerkship rotation and asking that each of them discuss this issue with their nursing managers, faculty and staff. At our undergraduate committee meetings, site coordinators have been instructed to speak with nursing staff at their sites about how they introduce students to patients and request that the nursing staff in clinics simply inform patients that a medical student will be involved in the clinic without specifying the gender of the student. Site coordinators have also been asked to ensure that there are signs in the waiting room informing patients about the affiliation of the unit with the University and that it is a teaching site for medical students. This complex issue has been discussed at University Department Executive and site departmental business meetings. A task force will be struck, consisting of faculty members, residents and medical students to discuss this issue in greater depth and to make recommendations which will facilitate the male medical student access to these clinical experiences.

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Challenges to Overcome:

In spite of the above successes, there remain smaller challenges. There is a continuing effort to optimize the rotation and, to that end, work is continuing by the departmental clerkship committee to address the following issues: 1. Continue to monitor student access to ambulatory care gynaecology experiences and work with the teaching sites to increase access, where required, in response to student feedback and student needs.

2. Implementing a six-week Obstetrics & Gynaecology clerkship program by 2013 at the Mississauga Academy which can deliver the complete set of 23 seminars in the standardized seminar program. Extensive support and faculty development with the departments have begun and will continue over the next 18 months.

3. Implement available videoconferencing technology for the purposes of delivering the seminar program to students at St. Joseph’s Health Centre and Toronto East General Hospital. This would minimize travel requirements for students assigned to these subrotation sites.

4. Increase access of male medical students to patient interactions through increased awareness and task force recommendations.

5. Promote involvement of faculty members in taking leadership positions in undergraduate committees such as Electives Committee, Integrated OSCE committee, Transition to Residency Committee.

Appendix 4.1.1 – Details of Rotation at Each of the Teaching Sites

North York General Hospital: 3 weeks of the rotation are spent in Labour and Delivery (a week in the beginning, middle and end of the rotation) and 3 weeks in an ambulatory care setting. During the labour and birth experience, students are paired with a nurse preceptor, which helps to expose students to interprofessional teams. For the ambulatory care component, the student spends 3.5 – 4 days of the first week with a staff gynaecologist, the second week in hospital ambulatory clinics (biophysical profiles clinic, medical disorder clinic, genetic counselling clinic, etc.) and a third week dedicated to the ward and operating room.

Sunnybrook Health Sciences Centre (previously Women’s College Hospital Site): The students spend 2 weeks in Labour and Delivery, 1 week in high risk clinic, 2 weeks with an assigned staff person following them in clinics and operating room and 1 week in a combination of activities, including gynaecology operating room, emergency room consultations, inpatient ward rounds, and a choice of attending either reproductive endocrinology and infertility, midwifery clinic or gynaecologic oncology clinic for one day. When students are with their assigned staff person for 2 weeks they complete 9 full clinic days.

St. Michael’s Hospital: The students spend 2 weeks in ambulatory care clinics, 2 weeks in labour and birth, one week in gynaecology inpatient and operating room, and one week in a combination of various other clinical settings. Six of the nine or ten students assigned to St. Michael’s spend 2 weeks at St. Joseph’s Health Centre in outpatient activities, operating room, inpatient gynaecology, and labour and birth. In the academic year 2010-11, a pilot program was initiated where 2 students in 2 blocks only were assigned to Trillium Health Centre for the middle two weeks of the rotation. This initiative was introduced in preparation for the year 2013 when clerkship will commence at the Mississauga Academy of Medicine. Two students volunteered for the assignment and two students were chosen randomly to fill the other two spots. The Course Director met with students prior to the start of the 2-week assignment to discuss any student concerns and to arrange transportation to Mississauga by taxi for any students who did not have their own means of transportation. Also, videoconferencing of all seminars from the St. Michael’s Hospital site to the Trillium site was arranged to facilitate student participation in the formalized seminar teaching program at their assigned site. Arrangements were made to have students dropped off at the Trillium site by taxi by 7:20 am in order to tune into the videoconferencing by 7:30 am. Students at Trillium were then ready to proceed to clinical duties by 8:30 am. In the academic year 2011-12, two students in every block will be given the opportunity to attend the Trillium Health Centre for two weeks of their six week rotation with similar mechanisms for travel and videoconferencing in place.

Mount Sinai Hospital: The students spend two weeks with their mentor doing eight full days in clinic during this time. One week is spent in labour and delivery (including one day where the student is paired with a nurse preceptor), one week in gynaecologic oncology (colposcopy clinic, gynaecologic oncology clinic and, possibly, operating room experience), one week in a community setting (St. Joseph’s Health Centre or Toronto East General Hospital) and one week filling gaps in their clinical experiences with any of the above experiences available. For example, if the student’s mentor is primarily involved in obstetrics, then time would be scheduled in gynaecology clinic during that week. As part of the same pilot project as described above for St. Michael’s Hospital, two students, in two blocks only, were assigned to Credit Valley Hospital in Mississauga during the 2010-11 academic year. Once again, two students volunteered and two were randomly assigned for this pilot project. Videoconferencing and taxi transportation were arranged for the students as described above. For 2011-12, two students in every block will be given the opportunity to attend Credit Valley Hospital for two weeks of their six-week rotation, with similar mechanisms in place for travel and videoconferencing.

Appendix 4.1.2 - Obstetrics and Gynaecology Clerkship - OBS310Y

2011-2012 – Detailed Course Objectives:

The Obstetrics and Gynaecology Clerkship rotation is designed to further develop and consolidate the knowledge, skills and attitudes acquired in preclerkship and to achieve clinical competence in managing common and important clinical problems that women may present within the discipline of obstetrics and gynaecology. The Obstetrics and Gynaecology Clerkship objectives are based on the CanMEDS competencies and meet the ED-2 standard of the LCME- CACMS.

A. General Competencies: 1. Medical Expert/Skilled Clinical Decision Maker 2. Communicator/Doctor-Patient Relationship 3. Collaborator 4. Manager 5. Health Advocate/Community Resources 6. Scholar 7. Professional

B. Educational Core Objectives: 1. Skills – Technical/Procedural 2. Problem Based Encounters

With respect to all the general competencies, the medical student should achieve the following:

A. General Competencies: 1. Medical Expert/Skilled Clinical Decision Maker a. Demonstrate the ability to assess and manage common and important problems which women will present within the discipline of Obstetrics and Gynaecology. b. Demonstrate the ability to take an obstetrical, gynaecological and sexual history. c. Develop a working differential diagnosis and management plan. d. Develop plans for investigation and interpret these investigations e. Understand and explain the risks and benefits of investigations and treatments. f. Demonstrate competency in pelvic examination and other basic procedural skills relevant to the discipline of obstetrics and gynaecology (see B.1) 2. Communicator/Doctor-Patient Relationship a. Communicate effectively and empathetically with patients and their families. b. Ensure that women have given informed consent before conducting and/or being present for examinations or procedures. c. Communicate effectively, respectfully and empathetically with women while performing and/or assisting at examinations and/or procedures. d. Demonstrate thorough and clear documentation and charting with concise recording of pertinent positive and negative findings. e. Demonstrate the ability to council and educate patients and families. f. Provide clear discharge instructions for patients and ensure appropriate follow-up care. g. Demonstrate the ability to present a patient case in a clear, concise and complete manner. 3. Collaborator a. Establish and maintain effective working relationship with colleagues and other healthcare professionals. b. Demonstrate an understanding of the concept of triage and prioritization of care in management of multiple patients simultaneously in the labour and birth unit. c. Demonstrate knowledge of other resources available to women when providing prenatal, intrapartum, postpartum and gynaecological outpatient and inpatient care. d. Maintain respect for the role of the patient’s primary care provider by ensuring that the provider is informed about the patient’s care plan. 4. Manager a. Demonstrate appropriate and cost-effective use of investigations and treatments. b. Develop an understanding of the organizational skills and efficiency required in managing patients and maintaining patient flow. c. Develop an understanding of the factors contributing to resource issues in outpatient prenatal and gynaecology clinics, in-hospital labour and birth and postpartum units, and inpatient gynaecologic and peri-operative services. 5. Health Advocate: a. Respond to the individual woman’s health care needs and issues as part of patient care. b. Understand the health needs of the community of women served by the health care unit. c. Identify the determinants of health of the population of women that is served by the health care unit. d. Understand methods to promote the health of individual women, communities and populations. 6. Scholar a. Access and critically appraise the literature relevant to obstetrics and gynaecology care. b. Understand the many unique learning and teaching opportunities available in Obstetrics and Gynaecology. 7. Professional a. Attend scheduled and assigned teaching and clinical responsibilities in a timely fashion. b. Communicate with educational administrators and clinicians when not able to attend scheduled assignments in a timely fashion. c. Recognize and accept his or her limitations and know when to ask for help. d. Protect information provided by or about patients, keeping it confidential, and divulge it only with the patient’s permission except when otherwise required by law. e. Be reliable and responsible in fulfilling obligations. f. Recognize situations where common medical errors may occur.

B. Educational Core Objectives

1. Skills-Technical/Procedural: By the end of the Obstetrics and Gynaecology Clerkship rotation, the medical student should be able to perform the skills/procedures listed below. Competencies to complete these skills may be acquired during clinical shifts, seminars, workshops, or simulations. a. Bimanual pelvic examination b. Vaginal speculum insertion c. Cultures of vagina and cervix d. Pap test e. Fetal heart rate tracing interpretation – normal and abnormal tracings f. Fetal heart auscultation with doptone g. Leopold manoeuvres h. Symphysis fundal height measurement i. GBS (group B streptococcus) culture for antenatal screening j. Nitrazine test for SROM (spontaneous rupture of membranes) k. Fern testing for SROM l. Cervical examination during labour m. Spontaneous vaginal birth n. Delivery and examination of placenta o. Obtaining cord blood

2. Problem Based Encounters By the end of the Obstetrics and Gynaecology Clerkship rotation, the student should be able to demonstrate an approach (including differential diagnosis, investigation and initial treatment) to women presenting for antenatal care, intrapartum care, gynaecological consultation (outpatient, inpatient, emergency room), and gynaecologic surgery, based on real or simulated encounters listed with the following issues:

Gynaecological: 1. Abnormal vaginal bleeding (pre and postmenopausal) 2. Adnexal mass and/or ovarian cyst 3. Amenorrhea/oligomenorrhea 4. Contraceptive methods 5. First trimester or early second trimester complications: - Spontaneous abortion, - Unwanted pregnancy and therapeutic abortion, - Ectopic pregnancy, - Recurrent pregnancy loss 6. Dysmenorrhea 7. Dyspareunia 8. Endometriosis 9. Fibroids 10. Genital tract infections 11. Incontinence 12. Infertility 13. Irregular periods 14. Menopausal counselling 15. Pap test counselling 16. Pelvic pain – acute and chronic 17. Post gynaecologic surgery complications 18. Sexual disorders 19. Urogenital prolapse/disorder 20. Vaginal discharge 21. Vulvar lesion or pruritis

Obstetrical: 1. Antepartum haemorrhage 2. Assisted birth (vacuum, forceps, Cesaerean delivery) 3. Fetal wellbeing issues: Genetic screening and prenatal diagnosis Small/large for gestation age fetus Management of Rh negative status Fetal demise 4. Diabetes in pregnancy 5. Hypertension in pregnancy 6. Induction of labour 7. Labour progression – normal and abnormal 8. Pain management in labour 9. Preterm labour 10. Preterm premature rupture of membranes 11. Nausea and vomiting in pregnancy 12. Postpartum care and complications Postpartum hemorrhage Postpartum fever Postpartum mood disorder 13. Obstetrical emergencies 14. Obstetrical ultrasound Appendix 4.1.3: TRES Manual Logging Sheet

Appendix 4.1.4: Standardized Seminar Program

Obstetrics: 1. Antepartum Care 2. Intrapartum Care 3. Postpartum Care 4. Pregnancy and Hypertension 5. Medical Disorders in Pregnancy 6. Antepartum and Postpartum Haemorrhage 7. Abnormal Labour and Obstetrical Emergencies-Part 1 8. Abnormal Labour and Obstetrical Emergencies-Part 2 9. Preterm Labour and PPROM 10. Fetal Complications-Part 1 11. Fetal Complications-Part 2

Gynecology: 12. Vulvar and Vaginal Disease and Lower Genital Tract STI’s 13. Acute Pelvic Pain, Cervicitis, and PID 14. Chronic Pelvic Pain 15. Early Pregnancy Complications 16. Infertility and Recurrent Pregnancy Loss 17. Menstrual Abnormalities in Premenopausal Women – Part 1 18. Menstrual Abnormalities in Premenopausal Women – Part 2 19. Contraception and Pregnancy Termination 20. Preinvasive and Invasive Diseases of the Lower Genital Tract 21. Pelvic Masses – Benign and Malignant Ovarian Neoplasms 22. Postmenopausal Bleeding and Endometrial Cancer 23. Menopause and Urogenital Aging

Appendix 4.1.5 – Midrotation Feedback Form

THIRD YEAR CLERKSHIP MID-ROTATION PROGRESS REPORT UNIVERSITY OF TORONTO, DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY

Student Name: ______Rotation: ______

Date, Time, Location of Meeting: ______

PLEASE CHECK ONE: MEETING EXPECTATIONS NOT MEETING EXPECTATIONS 1. History Taking 2. Pelvic Exam Skills 3. Factual Knowledge 4. Labour and Delivery Skills 5. Differential Diagnosis/ Clinical Judgment 6. Oral Presentation 7. Written Records 8. Professionalism

TRES 064 Report Reviewed Yes No AREAS NEEDING ATTENTION:

SUGGESTIONS FOR IMPROVEMENT:

Mentor/Co-coordinator ______Signature: ______Student’s Signature: ______Date: ______

Appendix 4.1.6: Department of Obstetrics and Gynaecology – U of T Clerkship Encounter Form

Student’s Name: ______Reviewed Form With Student: Yes  No  Supervisor’s Name: ______Supervisor Signature: ______Date: ______Duration of Encounter (e.g. 1 hr, ½ day, etc.): ______Setting: Gyn Clinic  Obs Clinic  OR  L&D  ER  Encounter: History Taking  (Observed  Not Observed ) Oral Presentation  Written Report  Pelvic Exam  Technical Procedure 

BELOW EXCEEDS N/ COMPETENCY UNSATISFACTORY EXPECTATIONS MEETS EXPECTATIONS EXPECTATIONS OUTSTANDING A Medical Expert: Wide gaps Comprehensive Advanced & complex knowledge knowledge Knowledge Medical Expert: Always incomplete Usually complete, Always concise, History Taking systematic precise, even if complex

Medical Expert: Misses major Usually detects Performs well even Pelvic Exam findings; major findings; when difficult insensitive sensitive Medical Expert: Unable to interpret Usually interprets Exceptional Test Interpretation appropriately understanding test results Medical Expert: Inappropriate Usually reasonable Exceptional judgment Clinical Judgment management in all approach of the complex settings Medical Expert: Unable to perform Performs basics Exceptional skill for Technical Procedure basics; avoids safely advanced procedures procedures Communicator: Insensitive, lack of Good rapport, shows Exceptional rapport, Patient and Family concern, remote concern, sensitive warmth and empathy even if difficult area Communicator: Incomplete, Generally complete, Thorough, concise, Written Records illegible, legible, organized sensitive even in disorganized complex situations Communicator: Incomplete, Usually complete, Exceptional ability to Oral Report illogical, difficult accurate and clear; present confidently even to follow some interruption to complex situations flow Collaborator: Uncooperative, Functions well as Offers to take on extra Team Participation & poorly integrated; team member; tasks; Understands how Interdisciplinary Care unaware of other understands use of professionals health care consultants collaborate even if providers challenging Manager: Unaware of Aware of resources; Exceptionally wise in Health Care Resources appropriate use of knows how to access resource management resources Scholar: Self-directed learner and No effort at self Demonstrates self Requests and learns contribution to other learning directed learning; directed learning; from all feedback; seeks events; Use of evidence-based late or absent for some contribution to knowledge; volunteers approach teaching sessions; rounds; will research for extra learning tasks never uses topics for evidence even if challenging evidence based based approaches to medicine management issues

Professional Behaviour: Unsatisfactory (Explain)  Satisfactory 

Comments:______Appendix 4.1.7

Cyclical Review Fall 2012 Self-Study

Appendix 4.1.8: Course Evaluation Data 2009-10 and 2010-11 2009-10 Year Three Clerkship Obstetrics & Gynaecology Evaluation Table 1: Ratings of Different Aspects of the Rotation Based on your own experience, please evaluate the following aspects: Percentage of Responses by Category Mean Response ASPECT of ROTATION Poor Fair Satisfactory Very Excellent Mean Std Dev Good 1 2 3 4 5 n=207 1. Orientation 1.4 1.9 23.2 50.2 23.2 3.92 0.82

2. Formal Seminars: 2.1 Program Coverage 0.5 0.5 17.4 39.6 42.0 4.22 0.78

2.2 Syllabus 1.4 2.4 17.4 47.8 30.9 4.04 0.84

3. Learning Objectives for: 3.1 Seminars -- 1.5 10.2 49.8 38.5 4.25 0.70

3.2 Ambulatory Care -- 2.4 13.7 54.6 29.3 4.11 0.72

3.3 Gyn Inpatient 1.5 8.5 25.4 45.3 19.4 3.73 0.92

3.4 Labour & Delivery -- 1.5 10.2 45.9 42.4 4.29 0.71

4. Informal Teaching: 4.1 Office 1.0 2.9 20.8 47.3 28.0 3.99 0.83

4.2 Ward Rounds 4.4 12.6 34.0 32.0 17.0 3.45 1.05

4.3 Labour & Delivery 1.4 3.9 15.5 42.0 37.2 4.10 0.90

4.4 OR 5.8 14.1 31.6 35.0 13.6 3.36 1.07 5. Acceptance on Team 1.4 6.8 20.3 48.8 22.7 3.85 0.90 6. OVERALL RATING

Overall, how would you rate your rotation in Obs/Gyn? 0.5 2.9 18.8 53.1 24.6 3.99 0.77

Cyclical Review Fall 2012 Self-Study

2009-10 Year Three Clerkship Obstetrics & Gynaecology Evaluation Table 2: Level of Agreement with Statements about Clinical Experience To what extent would you agree with the following statements about your clinical experience? Percentage of Responses by Level of Mean Response Agreement AREA of CLINICAL EXPERIENCE

Strongly Strongly Disagree Disagree Neutral Agree Agree Mean Std Dev

1 2 3 4 5 n=20 7

7. Patient Assessments: 7.1 Adequate # Gynaecology 4.3 21.3 24.6 32.9 16.9 1.12 3.37

7.2 Adequate # Obstetrics -- 1.4 3.4 44.9 50.2 .64 4.44

7.3 They were discussed -- 1.4 5.8 49.3 43.5 .66 4.35

8. Attempts to involve in OR 3.9 12.6 20.8 42.5 20.3 .06 3.63

9. Encouraged to flw pts in Labour -- 1.4 12.1 43.5 43.0 0.73 4.28

10. Ambulatory Clinic opps 1.0 5.3 19.9 39.3 34.5 .92 4.01

11. L&D opps for hands-on 0.5 2.9 9.7 43.5 43.5 .79 4.27

12. Balanced training/service -- 4.8 13.0 53.6 28.5 0.78 4.06

13. Nurses:

13.1 Felt part of the team 4.3 10.1 27.1 42.5 15.9 1.02 3.56

13.2 Helped augment skills 3.4 13.6 24.3 45.6 13.1 1.00 3.51

14. On-Call Experience:

14.1 Sufficient amount -- 0.5 2.9 50.5 46.1 0.58 4.42

14.2 Valuable learning 1.0 0.5 4.3 44.9 49.3 0.69

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4.41

14.3 Involved Emerg Dept 3.4 11.7 10.7 50.2 23.9 1.04 3.80

14.4 Called for deliveries 1.4 4.8 8.7 49.3 35.7 0.87 4.13

2009-10 Clerkship; October 2010

Cyclical Review Fall 2012 Self-Study

2010-11 Year Three Clerkship Obstetrics & Gynaecology Evaluation Table 1: Ratings of Different Aspects of the Rotation Based on your own experience, please evaluate the following aspects: Percentage of Responses by Category Mean Response ASPECT of ROTATION Poor Fair Satisfactory Very Good Excellent Mean Std Dev 1 2 3 4 5 n=196 1. Orientation 1.5 5.1 30.3 48.2 14.9 3.70 0.84 2. Formal Seminars: 2.1 Program Coverage 0.5 2.6 10.7 46.9 39.3 4.22 0.78

2.2 Syllabus 3.1 5.6 16.3 40.8 34.2 3.97 1.00

3. Learning Objectives for: 3.1 Seminars -- 3.1 10.3 47.9 38.7 4.22 0.75

3.2 Ambulatory Care -- 2.1 15.5 53.9 28.5 4.09 0.72

3.3 Gyn Inpatient 1.6 6.0 29.9 44.0 18.5 3.72 0.89

3.4 Labour & Delivery 0.5 0.5 13.4 44.8 40.7 4.25 0.74

4. Informal Teaching: 4.1 Office 1.0 4.1 17.9 52.0 25.0 3.96 0.83

4.2 Ward Rounds 3.1 14.4 33.3 32.3 16.9 3.46 1.03

4.3 Labour & Delivery 1.0 3.1 20.9 42.9 32.1 4.02 0.86

4.4 OR 4.6 11.2 36.2 33.7 14.3 3.42 1.02

5. Acceptance on Team 1.5 6.6 29.6 37.8 24.5 3.77 0.95

6. OVERALL RATING

Overall, how would you rate your 0.5 5.6 27.6 43.9 22.4 3.82 0.86 rotation in Obs/Gyn?

Cyclical Review Fall 2012 Self-Study

2010-11 Year Three Clerkship Obstetrics & Gynaecology Evaluation Table 2: Level of Agreement with Statements about Clinical Experience To what extent would you agree with the following statements about your clinical experience? % of Responses by Level of Agreement Mean Response Dis- AREA of CLINICAL EXPERIENCE Strongly agree Strongly Disagree Neutral Agree Agree Mean Std Dev

1 2 3 4 5 n=196

7. Patient Assessments: 7.1 Adequate # Gynaecology 2.6 14.3 20.9 42.9 19.4 3.62 1.03

7.2 Adequate # Obstetrics -- 1.5 7.1 43.4 48.0 4.38 0.69

7.3 They were discussed -- 1.0 8.2 44.9 45.9 4.36 0.68

8. Attempts to involve in OR 2.6 10.7 19.4 43.4 24.0 3.76 1.02

9. Encouraged to flw pts in Labour -- 2.0 11.2 48.0 38.8 4.23 0.73

10. Ambulatory Clinic opps 0.5 4.6 17.9 44.6 32.3 4.04 0.86

11. L&D opps for hands-on -- 5.1 16.8 45.9 32.1 4.05 0.83

12. Balanced training/service 1.5 2.6 14.3 55.1 26.5 4.03 0.81

13. Nurses:

13.1 Felt part of the team 4.1 11.3 25.1 43.1 16.4 3.56 1.02

13.2 Helped augment skills 4.6 11.8 28.2 37.4 17.9 3.52 1.06

14. On-Call Experience:

14.1 Sufficient amount 0.5 0.5 8.2 40.3 50.5 4.40 0.70

14.2 Valuable learning 0.5 3.1 9.2 42.9 44.4 4.28 0.80

14.3 Involved Emerg Dept 3.1 10.3 17.9 46.2 22.6 3.75 1.02

14.4 Called for deliveries 2.6 5.1 16.3 42.3 33.7 3.99 0.97

2010-11 Clerkship; October 2011

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4.2 POSTGRADUATE EDUCATION: RESIDENCY PROGRAM

4.2.1 Department of Obstetrics & Gynaecology — Residency Program Description

Obstetrics and Gynaecology is a five-year program leading to certification by the Royal College of Physicians and Surgeons of Canada. There are currently 60 residents in the program.

The PGY1 year incorporates four months of obstetrics and gynaecology (2 months in a community hospital), one month of neonatal intensive care, emergency medicine, ambulatory care and ultrasound; and two months each of general internal medicine and general surgery. The PGY1s have teaching sessions in the Surgical Skill Centre where they gain competency in obstetrics and gynaecological skills through simulation. They also participate in the Longitudinal Ambulatory Rotation (LAR) where they are connected to a faculty supervisor and visit their offices/ambulatory-care settings two times per month over the academic year. This affords an opportunity to connect with a faculty mentor in their chosen specialty.

The PGY2-5 years are comprised of the following rotations in accordance with Royal College of Canada requirements:  18 months CORE obstetrics and gynaecology  6 months Chief Residency  Subspecialty training in Maternal Fetal Medicine, Gynaecologic Oncology, Reproductive Endocrinology and Infertility, and Paediatric and Adolescent Gynaecology  9 months Selective (community ob/gyn, urogynaecology, pathology, and ultrasound)  3 months Research (2 separate six-week blocks) The 3-month research experience allows the resident exposure to either clinical or basic research under the guidance of identified researchers in the department. A paper must be completed and submitted for publication during the PGY5 year. All residents are required to present their final project at the Department's Annual Research Day. This three-month period is divided into two six-week blocks: the first block in a junior year of training, and the second block in the senior year. This allows residents time to start their project and develop it to completion.  3 months Elective Elective blocks where residents may pursue other subspecialties such as urogynaecology, International Health, Ultrasound and training in Lower Genital Tract Disease with achievement of certification as a colposcopist.

Training sites for the residents include: Mount Sinai Hospital (MSH), St. Michael's Hospital (SMH), Sunnybrook Health Sciences Centre (SHSC), North York General Hospital (NYGH), Toronto East General Hospital (TEGH), St. Joseph’s Health Centre (SJHC) Credit Valley Hospital (CVH), Princess Margaret Hospital (PMH) and The Hospital for Sick Children (HSC).

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4.2.2 O&G Residency Program — Objectives

Our program-specific objectives are as follows: 1. To provide broad-based clinical and academic training in Obstetrics and Gynaecology with the goal of creating the foundation for practice of general and subspecialty Obstetrics and Gynaecology 2. To fulfill all the objectives required for specialty training in Obstetrics and Gynaecology as described by the Royal College of Physicians and Surgeons of Canada 3. To focus on clinical experiences of a secondary and tertiary nature in general and subspecialty Obstetrics and Gynaecology, as seen in both a large academic health science centre and in community practice. 4. To provide graded responsibility in the acquisition of leadership skills and to emphasize development of teaching and research skills 5. To provide the environment, mentorship and experience that will allow each resident to achieve the goals outlined above.

4.2.3 O&G Residency Program — Admission Requirements

Admissions to the Obstetrics and Gynaecology residency program are centralized through CaRMS. Our Residency Selection Committee (comprising both faculty and residents) develops our selection process, consisting of reviewing files, interviewing selected candidates, and ranking. This committee reviews files from the CaRMS website to determine a maximum of 65 applicants who are invited to interview with us over two days. Interviews include one 20-minute interview with two faculty and one resident, one 10-minute interview with two residents, and one 10-minute interview with two faculty.

4.2.4 O&G Residency Program Committee (RPC)

The Residency Program Committee (RPC) assists the Residency Program Director in planning, organizing and supervising the residency rotations and programs. It is made up of the Program Director, a site coordinator from each affiliated site, subspecialty representatives, a resident representative for each year, a member of the Wellness team, Departmental Educator, Vice Chair of Education and the Chair of the Department. This active and dedicated committee meets monthly. (See attached terms of reference.) The responsibilities of this committee include: ensuring the program standards as required by the Royal College of Physicians and Surgeons of Canada are maintained, receiving feedback from residents, reviewing rotations, reviewing evaluations, deciding on resident promotions annually, regularly reviewing the goals and objectives of training, reviewing the content of the academic half-day, being responsible for discussing and recommending remediation or accommodation for residents, maintaining an appeal mechanism for residents in the program, providing counseling and career planning guidance and dealing with problems related to resident wellness and stress.

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4.2.5 O&G Residency Program — Delivery of Education

The Residency Program Committee (RPC) assists the Residency Program Director in planning, organizing and supervising the residency rotations and educational programs.

 Clinical Rotations (See 4.2.1 above).

 Academic Half-Day (AHD) Teaching Sessions: This is protected and residents attend in person The academic half-day teaching sessions encompass a variety of methods, including: —Surgical Skill Labs —Simulation Labs —Faculty-driven didactic sessions —Faculty/Resident sessions reviewing seminal papers and guidelines.

The curriculum topics reflect those of importance identified by a) the Royal College standards and b) the residents. In addition, we include topics covering resident-wellness issues such as coping with adverse events, and building resiliency. New in 2012-13: —Development of a transition-to-residency course or a “Boot Camp”. (See attached Curriculum). —For PGY4s only: This new course -- offered through the School of Graduate Studies starting in September 2012-- concentrates on physiology and molecular mechanisms underlying common clinical reproductive disorders. This will be invaluable for Royal College exam preparation.

 Rounds: (rotation or site-dependent). Grand rounds and a variety of weekly rounds at the various sites provide another venue of learning: e.g., Fetal Heart Rate Tracing Rounds, Pathology/Tumor Board, Critical appraisal, Perinatal-Neonatal Rounds.

 Research: Every resident must complete an independent research project and submit a paper for publication during the PGY5 year. A research mentorship program has been in place for a number of years. Every new resident is assigned to an established researcher in the Department to whom they can turn for guidance in developing research questions and finding a supervisor in their area of interest.

 Adjunctive Programs: The Department supports non-thesis Masters of Science and thesis Masters of Science education leaves. Two residents have recently completed a Masters in Clinical Epidemiology at Harvard University, two residents have completed the Clinical Investigator Program (CIP), and one resident is currently enrolled in the CIP.

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4.2.6 O&G Residency Program — Awards

4.2.6.1 Department Awards

 Dr. Frederick R. Papsin Award This award is presented annually to a postgraduate resident in his/her final year of training, based on teaching ability, mentorship activities and leadership. The recipient is selected by peers and members of the Residency Program Committee.

 Resident Awards for Excellence in Clerkship Teaching Each year, PGY2, 3, 4 and 5 residents are recognized for exceptional clerkship teaching. The Residency Program Director, in consultation with the Educator, Department Chair, and the Undergraduate Program Director makes the selection. The selection is primarily based on teaching ratings provided by the year-three clinical clerks at the completion of their core rotation in Obstetrics and Gynaecology

 The Neelam Sierra Resident Advocacy Award This award is presented to an individual who has been an exceptional advocate for residents in the department of Obstetrics and Gynaecology at the University of Toronto. The recipient (usually a faculty member) is selected annually by the graduating residents, based on their consistent support for the residents throughout their training.

4.2.6.2 Resident Recipients of Awards 2008-12

2011-12 RECIPIENT AWARD Helena Frecker PGY3 -Resident Teacher Award from the Fitzgerald Academy Crystal Chan PGY4 -$20,000 Physicians’ Services Incorporated Foundation grant Paulina Cybulska -$3,000 Kristi Piia CALLUM Memorial Fellowship in Ovarian Cancer PGY3 Research Paulina Cybulska -$17,000 Frank Fletcher Memorial Fund for Research PGY3 Kelsey Mills PGY3 and -Young Investigator award from the North American Menopause Society Maria Velasquez Crystal Chan PGY4 -One of five In-Training Awards for Research from the American Society of Reproductive Medicine

2010-11 Crystal Chan PGY3 -First place in the Clinical Alan Wu Poster Competition at the Institute of Medical Sciences Scientific Day Naana Jumah PGY3 -Canadian Foundation for Women's Health Duchesnay International Elective Fellowship for Obstetrics and Gynaecology Residents Kelsey Mills PGY2 -2011 New Investigator Awards given by the North American Menopause Society (NAMS) Ally Murji PGY5 -NYGH E.W. Wight Memorial Award Cyclical Review Fall 2012 Self-Study 35

Crystal Chan PGY3 -APOG President’s Grant for Resident Research Claire Jones PGY4 -CFWH (Canadian Foundation for Women’s Health) Resident Research Award.

2009-10 Jamie Kroft PGY5 -North American Menopause Society (NAMS)/Duramed Pharmaceutical Inc. Medical Residents Excellence Award

2008-09 Jamie Kroft PGY4 -SOGC/CNGOF Junior Member Award

2007-08 Karthika Devarajan -NYGH E.W. Wight, M.D. Memorial Award PGY2 Sarah Wallace PGY3 -Best of 4 Category at the SOGC meeting in Calgary for her poster submission Marie Czikk PGY2 -$19,500 grant for a one year resident research project from the Physicians’ Services Incorporated Foundation

4.2.7 O&G Residency Program — Funding

The residency in Obstetrics and Gynaecology is an Ontario Ministry of Health funded program. Residents who pursue a MSc at the University of Toronto are eligible for the B. Ludwig Scholarship. The Dr. Thomas G. Ryley Clinical Investigator Award supports residents in Obstetrics and Gynaecology who are enrolled in the Clinical Investigator Program.

4.2.8 O&G Residency Program — Quality Indicators

The following items may be found notable:  100% success in the first iteration of the CaRMS match for the past 13 years.  A calculated success rate of 97% for PGY5 candidates sitting the Royal College exams in the last 10 years (2002-12).  Two residents have completed the Clinical Investigator Program and currently one resident is enrolled.  Three residents have completed the Clinical Epidemiology Program at Harvard University in the past 5 years.  In 2010-11, eight residents were first authors on publications in peer-reviewed journals.

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4.2.9 O&G Residency Program — Quality Enhancement

 Split on-call shifts: In the past year, in an effort to address the issue of work/life balance and resident wellness, the Department has introduced split on-call shifts. A subcommittee is reviewing the literature on optimal work hours and will establish ground rules on how to optimize the scheduling of reduced resident duty hours. The initial feedback is positive, with an added benefit of better continuity of patient care. Faculty members are supportive of this endeavour.

 AHD concerns: Concerns about the quality of the academic half-day and associated protected time have been addressed. The AHD has now been extended to three hours and a new curriculum has been developed based on Royal College essential standards and resident feedback.

 Endoscopic procedures: Minimally-invasive surgical approaches are becoming the standard of care for providing surgical treatment for benign disease. In an effort to ensure that our residents demonstrate core competency in endoscopic procedures, the Department offered a Total Laparoscopic Hysterectomy Pig Lab supported by Covidien Canada. Residents gave rave reviews. The lab will continue for our PGY3s and 4s. There are also laparoscopic trainers and computer-based simulation programs at many of the core training sites.

 Wellness Team: The Wellness Team has been in existence since Jan 2011. It is chaired by Dr. Janet Bodley and includes three other faculty: Drs Michèle Farrugia, Elaine Herer, and Deborah Robertson. The mandate of this committee is to meet with residents about resident fatigue, stress or wellness issues, career planning, development of coping strategies such as sessions on being a resilient physician and developing reflective portfolios, and to debrief for adverse events. The team also presents topics during scheduled times of AHD. This endeavour has been very positively received by the residents. A member of the team attends every Resident Program Committee meeting.

 Biannual Meetings: The Resident Program Director meets one-on-one with each individual resident twice per year – these meetings provide an opportunity to review evaluations and progress, address performance issues, plan for education options based on interests, and obtain feedback about the program. The Department Chair meets with each resident year (PGY1-5) as a group twice per year – these meetings provide an opportunity for the Chair to stay in touch with the residents, hear the residents’ point of view, and for residents to express concerns.

DRAFT 2.22 Aug 02 2012 CS Page 1 of 4 APPENDIX 4.2.4.1

Residency Program Committee (RPC) Terms of Reference

1..Purpose

The purpose of the Department of Obstetrics & Gynecology RPC is to oversee the overall operation of the five-year residency program and to provide a forum to address all matters relating to Residents. For RPC responsibilities, see section 9.

2. Membership

Membership comprises the following:

2.1 Chair Residency Program Director 1 2.2 Site coordinators of Core Obstetrics Mount Sinai Hospital (MSH), St. Michael’s 3 and Gynecology rotations Hospital (SMH), and Sunnybrook Health Sciences Centre (SHSC) 2.3 Representatives from partially -Toronto East General Hospital (TEGH), 4 affiliated Sites -North York General Hospital (NYGH), -St. Joseph’s Health Center (SJHC), -Credit Valley Hospital (CVH) 2.4 Representatives from selected -Gynaecologic Oncology, 2 subspecialty rotation sites -Paediatric and Adolescent Gynaecology to (PAG) 4 -Gynaecologic Reproductive Endocrinology and Infertility (REI), -Maternal Fetal Medicine (MFM) 2.5 Evaluation Consultant - Department Education Consultant 1 2.6 Ex Officio -Department Chair 2 -Department Vice Chair, Education 2.7 Wellness Representative Wellness team member 1 2.8 Ethicist Invited by RPC 1 2.9 Resident Representative one for each PG year (elected by peers) 5 TOTAL 22

3. Meeting Schedule

3.1 The RPC meets once a month from September to June, usually from 4:30-6:00 pm. 3.2 Special meetings may be called at the discretion of the Chair.

4. Meeting Structure

4.1 The substantive sections of the meeting comprise:  Business arising  Standing reports: Resident Representatives, Hospital Coordinators, PGMEAC Report, Academic Half-Days and Attendance, and Rotation Review  New business 4.2 In-camera sessions: Resident evaluation is conducted in camera; Residents are excluded.

DRAFT 2.22 Aug 02 2012 CS Page 2 of 4 5. Governance

5.1 Quorum is defined as >50% of resident representatives and (minimum 3) >50% of faculty representatives. (minimum 8) 5.2 Motions are accepted with a 2/3 majority. 5.3 Chair: The RPC Chair is the Residency Program Director, Department of Obstetrics & Gynaecology, University of Toronto. The Chair reports to the -Chair, Department of Obstetrics & Gynecology, University of Toronto and -Vice Dean, Postgraduate Medical Education, University of Toronto. 5.4 The secretary is the Coordinator of Postgraduate Programs with the Department 5.5 The following subcommittees report to the RPC: 1. Resident Selection Subcommittee 2. Resident Wellness Subcommittee 3. Curriculum Subcommittee 4. Evaluation Subcommittee 5. Resident Research Sub-committee 6. Ad hoc subcommittees to serve a special identified need 5.6 All RPC members are voting members. 5.7 There is no limit on the term of service.

6. Communications / Documentation

6.1 The Program Coordinator: 6.1.1 takes minutes at each meeting 6.1.2 emails the agenda, minutes of past meeting, and relevant material to RPC members prior to each meeting 6.2.3 emails minutes to all faculty members and their assistants 6.2.4 posts minutes on the residents’ password-protected website, PORTAL. 6.2.5 maintains electronic and paper copies of all RPC meetings 6.2 RPC members are expected to disseminate information to their peers and to local sites. 6.3 The Department Chair disseminates specific important decisions to the whole department.

7. Individual RPC Member Responsibilities

7.1 RPC Faculty Members Responsibilities 7.1.1 Attend each RPC meeting or name delegate to attend 7.1.2 Disseminate information to peers and to local sites as appropriate 7.1.3 Respond to action items in a timely manner.

7.2 RPC Resident Representative Responsibilities 7.2.1 Attend each RPC meeting or name delegate to attend 7.2.2 Canvass resident group prior to each RPC meeting and present report at the meeting 7.2.3 Update residents on activities/decisions made at RPC meeting 7.2.4 Liaise with 92 College regarding teaching, administration, other issues 7.2.5 Participate in CaRMS: file review, interview and tour 7.2.6 Participate in Career/Information Night 7.2.7 Take a leadership role in Annual Resident Retreat 7.2.8 Act as contact for incoming PGY1s

8. Amendments These terms of reference are revised as required and approved by the RPC.

DRAFT 2.22 Aug 02 2012 CS Page 3 of 4 9. Overall Responsibilities of RPC:

RPC responsibilities are governed by the global objective of providing the environment, mentorship and uniform experience whereby each Resident has access to the educational experience sufficient to successfully complete the program objectives. Main responsibilities comprise the following areas.

9.1 Training Program Design Responsibilities

9.1.1 Develop and maintain program overall design 9.1.2 Annually review Royal College training requirements 9.1.3 Annually review individual rotation evaluations and address any need for change in program design 9.1.4 Address teaching /staff concerns (including faculty evaluations, if appropriate) that impact on rotations or overall program design 9.1.5 Review any hospital restructuring and effect on rotations and resource/equipment allocations 9.1.6 Annually review Resident Safety policy to ensure Resident work and personal safety (including supervision) are being met 9.1.7 Review annually fellowship numbers to assess any potential negative impact on residency education 9.1.8 Assess (ongoing) of areas of program design strengths and weaknesses 9.1.9 Ensure that Residents’ views are reflected in the program and curriculum review.

9.2 Training Program Curriculum Responsibilities

9.2.1 Develop and maintain curriculum that: a) incorporates outcome-based terms using the CanMEDS/CanMEDS-FM framework relating to knowledge, skills and attitudes b) bases content on the General Objectives for Training in Obstetrics and Gynaecology, as published in the specialty training requirements of the Royal College of Physicians and Surgeons of Canada 9.2.2 Annually review formal half-day topics and presentations and update as required 9.2.3 Maintain mechanisms by which residents receive ongoing career counseling 9.2.4 Review (ongoing) individual rotation goals and objectives.

9.3 Resident Evaluation Responsibilities

9.3.1 Review individual Resident performance at 6 and 12 month intervals to ensure that each Resident is advancing and gaining in experience, skills and responsibility 9.3.2 Assist in the organization of appropriate accommodation for residents experiencing difficulties meeting the appropriate level of competence 9.3.3 Assist Program Director with composite evaluation information for completion of the Final In Training Evaluation (FITER).

9.4 Resident Recruitment Responsibilities

9.4.1 Participate in application reviews, interviewing and ranking candidates. This Includes review of applicants through various streams of entry into program (CaRMS, re-entry, transfer, etc.).

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9.5 Resident Well-being Responsibilities

9.5.1 Review and formulate program support systems for formal / informal counseling and to address stress-related issues 9.5.2 Ensure that wellness topics are included in the academic half-day curriculum. 9.5.3 Maintain specific item of “Resident Report” on meeting agenda, whereby Resident committee members have the opportunity to discuss or raise specific items of Resident concern that may not otherwise be addressed in the meeting agenda.

9.6 Resident Issues Resolution and Appeals Responsibilities 9.6.1 Establish a process to respond to a resident’s wish to formally question, contest, or ask for reconsideration of an assessment or promotion decision.

Version Control Date Version No Author Approved at RPC Meeting June 12 2012 Draft 1.4 C Sutherland Sent to RPC June 14 2012 Jul 03 2012 Draft 1.5 C Sutherland Many iterations August 02 2012 Draft 2.2 C Sutherland

Appendix 4.2.5.1 Department of Obstetrics and Gynaecology, University of Toronto Page 1 of 4 Academic Half-Day Teaching 2012-13 REV: Sept 18, 2012 AN Green Font = Confirmed Red Font = To Be Confirmed XX = Requires Additional Supervisor Date PGY Location Time Topic Speaker(s) / Additional Notes JUL 03, SMH 16-101 Bruce 2:00 – 5:00 Kimberly Bremer, Heather PGY 1-2 Boot Camp: Management of Triage 2012 Lecture Theatre pm Millar JUL 10, SMH 16-101 Bruce 2:00 – 5:00 Boot Camp: How to Survive PGY 1-2 Steven Morris, Emily Baker 2012 Lecture Theatre pm Labour and Delivery JUL 17, SMH Li Ka Shing 2:00 – 5:00 PGY 1-2 Boot Camp: Ultrasound 101 Suzanne Wong 2012 Building Room 216 pm JUL 24, SMH 16-101 Bruce 2:00 – 5:00 Boot Camp: Coping with Genevieve Lennox, Brian Liu, PGY 1-2 2012 Lecture Theatre pm Emergency Consult Caroline Chan MONDAY JUL 30, PGY 4-5 Basement of MSB 4:00-6:00 pm Anatomy Prosection Lab Abheha Satkunaratnam 2012 2:00 – 4:00 Boot Camp: Gyne Surgergy 101 – Sari Kives, Matthew Morton, PGY 1-2 92 College St. JUL 31, pm Instruments & Sutures Deborah Robertson 2012 2:00 – 5:00 PGY 4-5 Basement of MSB Anatomy Course Abheha Satkunaratnam pm MONDAY AUG 06, PGY 4-5 Basement of MSB 4:00-6:00 pm Anatomy Prosection Lab Abheha Satkunaratnam 2012 SMH 16-101 Bruce 2:00 – 5:00 Boot Camp: Management of the Amanda Cipolla, Karli Mayo, PGY 1-2 AUG 07, Lecture Theatre pm Postpartum and Postop Floor Courtney Joliffe 2012 2:00 – 5:00 PGY 4-5 Basement of MSB Anatomy Course Abheha Satkunaratnam pm AUG 14, SMH 16-101 Bruce 2:00 – 5:00 Boot Camp: Fetal heart Rate PGY 1-2 Andrea Lausman 2012 Lecture Theatre pm Monitoring 101 MONDAY AUG 20, PGY 4-5 Basement of MSB 4:00-6:00 pm Anatomy Prosection Lab Abheha Satkunaratnam 2012 SMH 6-002 Cardinal 2:00 – 5:00 PGY 1-2 Carter – Clarice Boot Camp: Research 101 Helen Robson, Ted Brown pm AUG 21, Chalmers Room 2012 2:00 – 5:00 PGY 4-5 Basement of MSB Anatomy Course Abheha Satkunaratnam pm MONDAY AUG 27, PGY 4-5 Basement of MSB 4:00-6:00 pm Anatomy Prosection Lab Abheha Satkunaratnam 2012 2:00 – 5:00 PGY 1-2 92 College St. Boot Camp: Wellness Janet Bodley AUG 28, pm 2012 2:00 – 5:00 PGY 4-5 Basement of MSB Anatomy Course Abheha Satkunaratnam pm SMH 6-002 Cardinal SEP 04, 2:00 – 5:00 All PGYs Carter – Clarice PN Care Eva Mocarski 2012 pm Chalmers Room MSH Surgical Skills Dana Soroka, Jennifer Cram, PGY1 Surgical Skills: PGY 1 Centre – PMS Lab (247- 2:00-4:00 Georgina Wilcock, Perineal Injury & Repair SEP 11, 3) and VOR (247-2) Yolanda Kirkham 2012 SMH B1 Queen – Paul 2:00 – 5:00 Conduct of Normal Labour and PGY 2-5 Paul Bernstein Marshall Lecture Hall pm Delivery

SEP 18, SMH B1 Queen – Paul 2:00 – 5:00 Parturition: Biomolecular and All PGYs Wendy Whittle 2012 Marshall Lecture Hall pm Physiologic Processes

Marshall Barkin, SEP 25, MSH Surgical Skills PGY1 Surgical Skills: Knot Tying, PGY 1 2:00-4:00 Marcus Bernardini, 2012 Centre - Wet Lab (250) Suturing, Instruments Prati Sharma, Melissa Tai

Page 1 of 4 Appendix 4.2.5.1 Department of Obstetrics and Gynaecology, University of Toronto Page 2 of 4 Academic Half-Day Teaching 2012-13 REV: Sept 18, 2012 AN Green Font = Confirmed Red Font = To Be Confirmed XX = Requires Additional Supervisor Date PGY Location Time Topic Speaker(s) / Additional Notes Donna Steele, Sari Kives, 2:00 – 5:00 PGY 2-5 SMH 1 Bond Boardroom Instrumental Delivery Karen Tessler, Hani Akoury, pm XX SMH Li Ka Shing 1:00 – 5:00 PGY 1 Building – NRP Live Session NRP pm OCT 02, Room 217 & 218 2012 SMH 7079A Squires 2:00 – 5:00 PGY 2-5 Obstetrical Anaesthesia/Analgesia Carvahlo Family Room A pm MSH Surgical Skills Georgina Wilcock, Sari Kives, PGY1 Surgical Skills: Wound PGY 1 Centre – PMS Lab (247- 2:00-4:00 Heather Shapiro, Closure/Marsupialization OCT 09, 3) and VOR (247-2) Yolanda Kirkham 2012 Li Ka Shing, Rm. 217- 2:00 – 5:00 Tatiana Freire-Lizama PGY 2-5 Obstetrical Emergencies 218 pm More OB

OCT 16, SMH 7079A Squires 2:00 – 5:00 Management of Abnormal Labour All PGYs Gareth Seaward 2012 Family Room A pm in the First and Second Stage MSH Surgical Skills PGY1 Surgical Skills: Operative Melissa Tai, Donna Steele, PGY 1 Centre – PMS Lab (247- 2:00-4:00 Delivery – Vacuum & Forceps Karen Tessler, Paul Bernstein OCT 23, 3) and VOR (247-2) 2012 SMH 6-002 Cardinal 2:00 – 5:00 Janet Bodley, Michelle PGY 2-5 Carter – Clarice Wellness pm Farrugia Chalmers Room OCT 30, SMH 7079A Squires 2:00 – 5:00 Intrapartum Surveillance and FHR All PGYs Howard Berger 2012 Family Room A pm Nomenclature MSH Surgical Skills Melissa Tai, Hani Akoury, PGY1 Surgical Skills: PGY 1 Centre – PMS Lab (247- 2:00-4:00 Tatiana Freire-Lizama, Shoulder Dystocia NOV 06, 3) and VOR (247-2) Marshall Barkin 2012 Antepartum Fetal Surveillance, SMH 7079A Squires 2:00 – 5:00 PGY 2-5 Placental Markers, and Disorders Dini Hui Family Room A pm of Amniotic Fluid NOV 13, SMH B1 Queen – Paul 2:00 – 5:00 Hypertensive Disorders in All PGYs Kingdom, Ghandi 2012 Marshall Lecture Hall pm Pregnancy MSH Surgical Skills PGY1 Surgical Skills: Melissa Tai, Hani Akoury, PGY 1 2:00-4:00 Centre – Wet Lab (250) B-Lynch Sutures Tatiana Freire-Lizama, XX NOV 20, 2:00 – 3:30 LGBTQ Rachel Epstein 2012 SMH 7079A Squires pm PGY 2-5 Family Room A 3:30 – 5:00 Aboriginal Health Rajiv Shah, Naana Jumah pm NOV 27, SMH 7079A Squires 2:00 – 5:00 All PGYs Diabetes Type 1 and Type 2 Howard Berger 2012 Family Room A pm DEC 04, SMH B1 Queen – Paul 2:00 – 5:00 All PGYs Global Health Rachel Spitzer 2012 Marshall Lecture Hall pm SMH 6-002 Cardinal DEC 11, 2:00 – 5:00 All PGYs Carter – Clarice PPROM and Preterm Labour Andrea Lausman 2012 pm Chalmers Room DEC 18, SMH B1 Queen – Paul 2:00 – 5:00 Department Chair – Meeting with All PGYs Alan Bocking 2012 Marshall Lecture Hall pm Residents DEC 25, SMH 7079A Squires 2:00 – 5:00 All PGYs HOLIDAY – No Teaching N/A 2012 Family Room A pm JAN 01, SMH 16-101 Bruce 2:00 – 5:00 All PGYs HOLIDAY – No Teaching N/A 2013 Lecture Theatre pm JAN 08, 2013 PGY 1 MSH Surgical Skills 2:00-4:00 PGY1 Surgical Skills: IUD Insertion Paul Bernstein, Centre – PMS Lab (247- Rachel Spitzer, Page 2 of 4 Appendix 4.2.5.1 Department of Obstetrics and Gynaecology, University of Toronto Page 3 of 4 Academic Half-Day Teaching 2012-13 REV: Sept 18, 2012 AN Green Font = Confirmed Red Font = To Be Confirmed XX = Requires Additional Supervisor Date PGY Location Time Topic Speaker(s) / Additional Notes 3) and VOR (247-2) Melanie Ornstein, Wendy Wolfman

SMH 16-101 Bruce 2:00 – 5:00 PGY 2-5 Modes/Induction/Success Jackie Thomas Lecture Theatre pm JAN 15, SMH 16-101 Bruce 2:00 – 5:00 All PGYs Multiples John Barrett 2013 Lecture Theatre pm PGY1 Surgical Skills: MSH Surgical Skills Ari Baratz, Rebecca Arthur, PGY 1 2:00-4:00 Laparoscopic Principle/Tubal Centre – Wet Lab (250) Wusun Paek, Stephen Im JAN 22, Ligation 2013 SMH 16-101 Bruce 2:00 – 5:00 PGY 2-5 C/section Rory Windrim Lecture Theatre pm JAN 29, SMH 16-101 Bruce 3:00 – 5:00 All PGYs Ethics OB Jodi Shapiro 2013 Lecture Theatre pm MSH Surgical Skills PGY1 Surgical Skills: Surgical Ari Baratz, Melanie Ornstein, PGY 1 2:00-4:00 FEB 05, Centre – Wet Lab (250) Management of Ectopic Pregnancy Lisa Allen, Kimberly Liu 2013 SMH 16-101 Bruce 2:00 – 5:00 PGY 2-5 Dysmenorrhea and Endometriosis Alexandra Nevin-Lam Lecture Theatre pm FEB 12, SMH 16-101 Bruce 2:00 – 5:00 Michelle Farrugia, All PGYs Wellness 2013 Lecture Theatre pm Janet Bodley Alexandra Nevin-Lam, MSH Surgical Skills PGY1 Surgical Skills: PGY 1 2:00-4:00 Ari Baratz, Rebecca Arthur, Centre – Wet Lab (250) Ovarian Cystectomy FEB 19, Stephen Im 2013 SMH 16-101 Bruce 2:00 – 5:00 PGY 2-5 Contraception Elyse Lackie Lecture Theatre pm FEB 26, SMH 16-101 Bruce 2:00 – 5:00 All PGYs Mennorhagia/AUB Abheha Satkunaratnam 2013 Lecture Theatre pm PGY1 Surgical Skills: Nicholas Pairaudeau, MSH Surgical Skills PGY 1 2:00-4:00 Hysteroscopic Endometrial Jennifer Cram, Fay Weisberg, Centre – Wet Lab (250) MAR 05, Resection Abheha Satkunaratnam 2013 SMH 16-101 Bruce 2:00 – 5:00 PGY 2-5 Ultrasound in Gynecology Sue Wong Lecture Theatre pm MAR 12, SMH 16-101 Bruce 2:00 – 5:00 All PGYs Benign Vulvar Diseases Deborah Robertson 2013 Lecture Theatre pm MSH Surgical Skills Alexandra Nevin-Lam, PGY1 Surgical Skills: PGY 1 Centre– PMS Lab (247- 2:00-4:00 C.D. McDermott, Melissa Tai, Bladder Repairs MAR 19, 3) and VOR (247-2) Danny Lovatsis 2013 SMH 16-101 Bruce 2:00 – 5:00 Pelvic Pain, Vulvodyia and PGY 2-5 Elyse Levinsky Lecture Theatre pm Vaginismus MAR 26, SMH 16-101 Bruce 2:00 – 5:00 All PGYs Ovarian Cyst Jodi Shapiro 2013 Lecture Theatre pm Melissa Tai, Jason Dodge, MSH Surgical Skills PGY1 Surgical Skills: PGY 1 2:00-4:00 Marcus Bernardini, Centre – Wet Lab (250) Bowel(/Vascular) Repairs APR 02, Joan Murphy 2013 SMH 16-101 Bruce 2:00 – 5:00 PGY 2-5 Menopause Wendy Wolfman Lecture Theatre pm APR 09, SMH 16-101 Bruce 2:00 – 5:00 All PGYs Uterine Fibroids Grace Liu 2013 Lecture Theatre pm MSH Surgical Skills PGY1 Surgical Skills: Review of Melissa Tai, Donna Steele, PGY 1 2:00-4:00 APR 16, Centre – Wet Lab (250) Operate Delivery Karen Tessler, Paul Bernstein 2013 SMH 16-101 Bruce 2:00 – 5:00 Post-Op Care and Management of PGY 2-5 Guylaine Lefebvre Lecture Theatre pm Complications APR 23, SMH 16-101 Bruce 2:00 – 5:00 All PGYs TBD TBD 2013 Lecture Theatre pm Page 3 of 4 Appendix 4.2.5.1 Department of Obstetrics and Gynaecology, University of Toronto Page 4 of 4 Academic Half-Day Teaching 2012-13 REV: Sept 18, 2012 AN Green Font = Confirmed Red Font = To Be Confirmed XX = Requires Additional Supervisor Date PGY Location Time Topic Speaker(s) / Additional Notes APR 30, SMH 16-101 Bruce 2:00 – 5:00 All PGYs TBD TBD 2013 Lecture Theatre pm MAY 07, SMH 16-101 Bruce 2:00 – 5:00 All PGYs Gyne Oncology Jason Dodge (Coordinating) 2013 Lecture Theatre pm MAY 14, SMH 16-101 Bruce 2:00 – 5:00 All PGYs Gyne Oncology Jason Dodge (Coordinating) 2013 Lecture Theatre pm MAY 21, SMH 16-101 Bruce 2:00 – 5:00 All PGYs Gyne Oncology Jason Dodge (Coordinating) 2013 Lecture Theatre pm Alexandra Nevin-Lam, MSH Surgical Skills OSATS (Objective Structured PGY 1 2:00-4:00 Karen Tessler, Amanda Selk, Centre – Wet Lab (250) Assessment of Technical Skills) MAY 28, Heather Shapiro 2013 SMH 16-101 Bruce 2:00 – 5:00 PGY 2-5 Gyne Oncology Jason Dodge (Coordinating) Lecture Theatre pm JUN 04, SMH 16-101 Bruce 2:00 – 5:00 Michelle Farrugia, All PGYs Wellness 2013 Lecture Theatre pm Janet Bodley JUN 11, SMH 16-101 Bruce 2:00 – 5:00 All PGYs Gyne Oncology Jason Dodge (Coordinating) 2013 Lecture Theatre pm JUN 18, SMH 16-101 Bruce 2:00 – 5:00 All PGYs Gyne Oncology Jason Dodge (Coordinating) 2013 Lecture Theatre pm JUN 25, SMH 16-101 Bruce 2:00 – 5:00 All PGYs TBD TBD 2013 Lecture Theatre pm

Page 4 of 4 Cyclical Review Fall 2012 Self-Study 37

4.3.1 Fellowship Programs in the Department of Obstetrics and Gynaecology: Description

Table 1 provides an overview of the fellowship programs in our department.

Table 1. Clinical Fellowship Programs: 2011-12 and 2012-13

FELLOWSHIP PROGRAM PROGRAM NUMBER OF (site) DIRECTOR FELLOWS 2011-12 2012-13 1 Advanced High-Risk Obstetrics Howard Berger 1 2 (St. Michael's Hospital) 2 Advanced Obstetrics Gareth Seaward 3 2 (Mount Sinai Hospital) 3 Advanced Obstetrics (SHSC) Dini Hui 1 2 4 Gynaecologic Endoscopic Artin Ternamian 1 1 Surgery (St. Joseph's Health Centre) 5 Gynaecologic Oncology/ RCPSC Alan Covens 7 7

6 Gynaecologic Reproductive Barbara Cruickshank 3 4 Endocrinology &Infertility/RCPSC 7 Maternal-Fetal Medicine/ RCPSC Cynthia Maxwell 14 16 8 Mature Women's Health & Wendy Wolfman 0 2 Menopause (MSH) 9 Minimally Invasive Rose Kung 1 1 Gynaecologic Surgery/AAGL (SHSC) 10 Minimally Invasive Guylaine Lefebvre 3 3 Gynaecologic Surgery (SMH) 11 Pediatric & Adolescent Sara Kives 1 1 Gynecology (HSC) 12 Reproductive Sciences (Toronto Robert Casper 4 7 Centre for Assisted Reproductive Technology) 13 Reproductive Sciences (CReATe Clifford Librach 1 2 Fertility Centre) 14 Urogynaecology (SHSC) Rose Kung 1 1 15 Urogynaecology (MSH) Danny Lovatsis 5 6

TOTAL 46 57*

*NOTE: This number represents some Fellows continuing from 2012 for under 12 months.

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Objectives of Fellowship Each program has unique goals and objectives, but all adhere to the standards set by the department with respect to admission, and evaluation. There is a template for educational objectives for clinical fellows, in order to reduce variability and ensure a more consistent approach to education for clinical fellows. For details of specific fellowships, see http://www.obgyn.utoronto.ca/fellowships.htm

Admission Requirements and Process

A department wide template for the application process is used. http://www.obgyn.utoronto.ca/Assets/OBGYN+Digital+Assets/Fellowships/Fellowship+Application+For m.pdf Guidelines for the applicant are also provided. http://www.obgyn.utoronto.ca/fellowships/Appointment-Guidelines.htm

Delivery of Education and Quality Enhancement There is a Fellowship Directors Committee compromised of all Fellowship Directors. This committee meets quarterly. There are trainee representatives on the committee. Its goals are to advance the educational experience of the fellows. Towards that end there are university wide fellowship seminars open to all subspecialties organized by the committee. The committee also serves as a venue to share best practices among the fellowship directors. Specifics of education delivery are at the discretion of the program director. The Vice Chair, Education has as her mandate to support the fellowships and the directors, as the Fellowship Director Committee Chair. Many of the directors have small programs with minimail administrative support. Caroline Sutherland Coordinator, the Postgraduate Programs in the Department of Obstetrics & Gynaecology offers invaluable education on the process and is the link to the PGME office of the university.

Funding and Awards Approximately 40% of the fellows are Canadian or Canadian trained and 60% are international graduates. The three subspecialty PGY6 (denoted as FRCSC) programs fall under the umbrella of the Fellowship Training programs. These trainees receive funding from the Ministry of Health; the others have multiple funding sources. The subspecialty residency programs are accredited by the RCPSC. The standards for the other programs are set by the university and the department. It is a policy of the University of Toronto that foreign nationals receive remuneration as a clinical fellow or research fellow at a rate commensurate with that of a Canadian performing the same duties in the same location of work as the foreign national. This statement is included in all letters of offer. RCPSC residents are eligible for a number of university, provincial and national awards. RCPSC and non RCPSC trainees are eligible for department recognition for teaching.

Quality Indicators

A measure of success of our fellowships can be found in the results of the 2012 University of Toronto Fellowship survey. This was answered by 21 Ob/Gyn fellows. This is consistent with the overall response rate of 58%. In this survey, 77% found that ease of registration at the main clinical site met or exceeded expectation. The same number felt orientation to clinical department policies and procedures, call schedules, departmental faculty and staff met or exceeded expectations. The biggest challenges for our fellows are with respect to funding, orientation to the hospital system and general licensing and Cyclical Review Fall 2012 Self-Study 39

accreditation processes. 52% of Ob/Gyn fellows are paid $50, 000- 70,000 / yr by the department. A third are paid by their sponsoring government. 14% earn $20, 000 or less. A comparison of the Obstetrics and Gynecology fellows’ impression to the that of the Univeristy wide fellows is shown in Table 2 and Table 3.

Eighty-seven percent of our fellows would recommend a fellowship at U of T.

Table 2. Education Rating by Exiting Fellows 2012 Obs/Gyn % (N=21) All Depts % Quality of Teaching (N=514) Unsatisfactory 0 2 Below expectations 10 12 Meets expectations 62 35 Above expectations 10 29 Outstanding 19 33 Quality of patient care experiences Unsatisfactory 0 0 Below expectations 0 4 Meets expectations 47 40 Above expectations 29 33 Outstanding 14 23

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Table 3. Service and Education Experience of Exiting Fellows 2012 Obs/Gyn % (N=21) All Depts % Overall education (N=514) Ratings Unsatisfactory 0 1 Below expectations 0 6 Meets expectations 71 40 Above expectations 29 32 Outstanding 10 21 Suitable amount of non-educational service work Unsatisfactory 10 5 Below expectations 0 10 Meets expectations 71 53 Above expectations 10 19 Outstanding 10 14

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4.3.2 Gynaecologic Oncology Fellowship Program Director: A. Covens MD, FRCSC

The University of Toronto Gynaecologic Oncology Fellowship has been in place since 1984. Since that time it has produced over 70 Gynaecologic Oncologists, many practising around the world. Over half the Gynaecologic Oncologists currently practising in Canada have been trained in Toronto.

For the past 10 years the program has been of 3 years duration, one academic year and two clinical years. It is accredited by the Royal College of Physicians and Surgeons of Canada. The details of the 2 year clinical Canadian requirements for training can be found at http://rcpsc.medical.org/information/index.php?specialty=427&submit=Select.

The academic year can be spent completing one of a variety of initiatives. The options include, but are not limited to: a Masters program in clinical epidemiology, public health, or continuing medical education, or basic science research. Our program is flexible to allow the trainee and fellowship director to tailor the academic year towards interests, strengths, and needs/future career goals. In some cases this is completed partially or wholly outside of Toronto. As a consequence of our academic year, over half the abstracts presented at the Society of Gynaecologic Oncologists of Canada Meeting are from Toronto fellows. Each fellow has at least 1-2 publications at the completion of training.

The 2 year clinical training is very robust. The University of Toronto is the only medical school in the city of Toronto (catchment population 5 million). As well, in Canada, there is no private practice Gynaecologic Oncology, so all such surgeons reside within a University system. At present, there are 11 Gynaecologic Oncologists affiliated at the 2 main hospitals – Sunnybrook Health Sciences Centre and the University Health Network. As well, the Gynaecologic Oncologists run peripheral clinics at the Durham Regional Cancer Centre in Oshawa, and operate at a number of community hospitals in the area: Credit Valley Hospital, North York General Hospital, and Scarborough General Hospital.

There are 2 fellows accepted into the program/year. At any one time, there are 2-3 fellows doing Gynaecologic Oncology at the 2 main hospitals, and 1-2 fellows on off-service rotations such as medical oncology, radiation oncology, pathology, and ICU. The fellows do 18 months of Gynaecologic Oncology.

During typical rotations, fellows are evaluating new patients in the clinic, monitoring chemotherapy patients, and following patients. Each week, the fellow spends 3-4 full days in the OR. Their role in the OR is graduated responsibilities from first assistance to primary surgeon. At the completion of the fellowship, fellows are expected to be competent in all aspects of gynaecologic oncology, including laparoscopic surgery, and robotic surgery. Sunnybrook Health Sciences Centre has particular expertise in laparoscopic surgery, while University Health Network is developing expertise in robotic surgery. Both centres are fully functioning units encompassing the full breadth of services from colposcopy to ultra radical surgery, to palliative care, and clinical trials. Cyclical Review Fall 2012 Self-Study 42

Rounds include city-wide gynaecologic oncology twice per month, morbidity and mortality once per month, tumour board weekly, and pathology weekly. Every Wednesday afternoon is the fellowship curriculum. This 2-3 hour weekly program includes interactive discussions on topics including various cancers, the biology of cancer, communication skills and surgical issues.

The fellowship is funded from a variety of sources, including the Ministry of Health through the PGME office, the Gynaecologic Oncology APP, and grants held within the division of Gynaecologic Oncology. Our mission is to select the best candidates, regardless of citizenship, with an emphasis on academics. We strive to produce future academic leaders in Gynaecologic Oncology.

The strengths of the program include: A large faculty with a large volume of gynaecologic oncology patients An internationally renowned faculty Expertise in minimally invasive surgery, gestational trophoblastic disease, sentinel lymph nodes, and fertility-sparing surgery Funding for all 3 years of training, including the academic year Flexibility in tailoring the academic year to the fellow’s strengths, interests and needs Protected academic time Large robust core curriculum

Weaknesses include: A large program, with a large faculty, and a large number of fellows (6) The expense of Toronto as a place to live Travel between hospitals and sites is cumbersome The academic year is mandatory, and individuals wishing clinical training only are discouraged from applying

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4.3.3 Maternal-Fetal Medicine Fellowship Program Program Director: Cindy Maxwell MD, FRCSC (Ob/Gyn& MFM), RDMS, DABOG

Synopsis since last External Review (2006/2007) Our two-year program continues to be the largest in Canada. Since the last Royal College visit for External Review, our program officially became a RCPCS Residency in MFM by certification (written examination). We continue to train highly-qualified Canadian (residents) and International Medical graduates (IMG fellows) in MFM who are destined to become leaders in the field, in academic centres in Canada and internationally.

We are fortunate to have such a strong University of Toronto Division of MFM to support our program, with the majority of our faculty holding full professorships, a continued tradition of extensive grant funding and high basic science and clinical research output.

Our program is now funded by the Ontario Ministry of Health to support 2 Canadian fellows annually; this year we have substantial competition for these 2 positions as we have four applicants. Our Division continues to support and fund one IMG applicant. We also consider additional strong applicants who may come with partial or full national/regional/institutional funding. These applicants tend to have advanced degrees at the PhD level or a substantial academic track record prior to their arrival in Toronto.

The program integrates the three teaching sites: Sunnybrook (previously situated at the Women’s College Campus) Health Sciences Centre provides one of the in-patient perinatology ward rotations and provides a significant teaching component for the Ultrasound Imaging Rotation; St. Michael’s Hospital is now the home base for the very successful Ultrasound Imaging rotation, a mandatory component of RCPSC MFM fellowship training; our fellows/residents continue to have advanced rotations in fetal echocardiography at Hospital for Sick Children.

Our program continues to be unique in Canada and internationally for its Fetal Therapy and Surgery program, with the fetal twin laser program treating approximately 50-70 patients per year. Furthermore, our program offers a unique experience in medical disorders of pregnancy, with a formal program in Maternal Medicine and Obstetric Medicine based at Mount Sinai Hospital.

Future Directions There has been much discussion in the past regarding the achievement of recognition with other MFM Colleges. We have successfully reapplied for recognition of our MFM program by the RCOG (UK) in June 2012. This reciprocity allows fellows trained and certified in the UK to count their training in Toronto towards programs in the UK.

We have also discussed pursuing ABOG certification (US) for our program. The main challenge here is that the US programs are structured over 3 years with 18 months of research required in the first half of the program. As our program is a 2 year program with 6 months of research Cyclical Review Fall 2012 Self-Study 44

required, additional funding would be needed to enable our fellows to train longer and qualify for ABOG certification examinations. Although we have one faculty member who is ABOG – MFM certified, two such faculty are required to be on staff to meet ABOG regulations. Changes are underway in the ABOG programs, where the research requirement may be shortened to 12 months based on the documented research productivity of US graduates in recent years. We will continue to follow these developments in relation to our program. The goal of recruiting an ABOG-certified MFM faculty member is still on the agenda for our division.

Respectfully submitted,

Cindy Maxwell Cynthia Maxwell, MD, FRCSC (Ob/Gyn& MFM), RDMS, DABOG Staff Perinatologist, Maternal Fetal Medicine Division, Mount Sinai Hospital Assistant Professor, Department of Obstetrics and Gynaecology Director, Maternal Fetal Medicine Training Program University of Toronto

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4.3.4 Gynaecologic Reproductive Endocrinology and Infertility (GREI) Fellowship Programme

Programme Director Barbara E. Cruickshank

The GREI Fellowship programme is a two year subspecialty training programme accredited by the Royal College of Physicians and Surgeons of Canada. This programme initially received Royal College accreditation in June, 2002 and, after an external review by the Royal College in April 2007, was granted full approval for a period of 6 years.

The GREI fellowship programme of the Mount Sinai Hospital Centre for Fertility and Reproductive Health is one of the largest of the eight RCPSC programmes in Canada.

The objective of the GREI Fellowship training programme is to train Fellows of the Royal College of Physicians and Surgeons qualified in Obstetrics and Gynaecology to achieve a rounded academic and clinical experience in all aspects of GREI, with a focus on career preparation for academic productivity and outpatient management. The programme maintains three fellows in training at any one time, all of whom spend two years completing their GREI training rotations. All trainees are PGY 6 and 7 status, following completion of residency training in Obstetrics and Gynaecology and qualification through the Royal College of Physicians and Surgeons of Canada. In September 2012, the first certification examinations will be offered by the Royal College of Physicians and Surgeons of Canada for the subspecialty of GREI. All trainees who qualify now will complete the certification with examination process.

The GREI Fellowship Programme of the Mount Sinai Hospital Centre for Fertility and Reproductive Health (CFRH) is a multidisciplinary training programme which incorporates academic and clinical exposure in a number of related subspecialty areas which include paediatric and adolescent gynaecology offered through specialty clinics and related surgery at the Hospital for Sick Children (Sick Kids), general endocrinology and urology (with a specific focus on male infertility).

Trainees also have a unique focused GREI exposure through Menopause Clinics and Premature Ovarian Failure (POF) multidisciplinary clinics. Under the supervision of a clinic mentor, trainees have the unique opportunity to manage their own clinics (one or two half days per week) which offers longitudinal management exposure continuously over the two year period of training. During the one month per year of elective experience, fellows have the opportunity to augment specific aspects of their training.

Through the course of training, Fellows attend a course in Biostatistics. They have at least six months of protected time to devote to research, with extensive resources available to support their research projects. Fellows receive initial orientation to research by the Head of the Division of REI at the University of Toronto, Dr Ted Brown, after which they develop, submit to the appropriate Ethics Board for approval, carry out and analyze at least one research project deemed by their supervisor to be suitable for submission for publication to a peer reviewed journal. Trainees have access to a wide array of resources from basic science, statistical analysis resources, and clinical material to pursue their research projects. Cyclical Review Fall 2012 Self-Study 46

The REI Division supports 3 basic scientists and 1 clinical/translational research scientist and these individuals offer further educational resources for trainees. Fellows are able to compete for a research grant through the Department of Obstetrics and Gynaecology, and several of the GREI fellows have received research support funds through this avenue in recent years. Fellows present their research at both international and national meetings as well as the University of Toronto Department of Obstetrics & Gynaecology Annual Research Day. For the past two years, a GREI Fellow has been awarded the J.W. Knox Ritchie Research Award (Fellow Category).

The GREI Fellowship programme promotes education of other trainees by the GREI fellows at a variety of levels. Residents in Obstetrics and Gynaecology receive formal teaching sessions by our Fellows while they are on rotation in the specialty and are directly evaluated on this activity by the residents. Fellows in General Endocrinology from the Department of Medicine also rotate through the GREI programme, offering our trainees a unique exposure to a different perspective on endocrinology. Fellows also participate in the clinical education of the University of Toronto medical students as they rotate through the Canadian Fertility and Andrology (CFAS) site.

Fellows in GREI are expected to take on a Health Advocate Project, which may include developing CFRH clinical guidelines on new techniques, or teaching IVF Education classes or Family Medicine Residents aspects of infertility.

Fellows are funded as PGY 6 and 7 residents of the University of Toronto Residency Training programme, with access to the full and extensive training and wellness resources of the university Postgraduate Medical Education programme. In addition, there is a Fellowship Education Fund supported by unrestricted industry grants which supports educational and research tools and resources to enrich the educational and training experience of the Fellows. Funding is provided to support expenses for attendance at national and international meetings when paper are presented, as well as attendance at the annual meeting of the national society (CFAS).

The strengths of the programme, as identified by the RCPSC external review in 2007 and, more recently, following the internal review of 2011, are many, and include: Volume and scope of clinical material Environment of scholarship/academia Collaborative environment/structure and physical space that encourages collaboration Structured training in related specialty fields Resources for research and protected time for research Innovative programme director and enthusiastic faculty

Current challenges are: Resources (physical space, number of faculty) limit the ability of the programme to accept more trainees per year The administrative load required to meet requirements of a RCPSC programme is essentially identical to that of a specialty programme, but the resources are more limited and there are fewer teaching faculty in such a small programme.

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4.4. Continuing Medical Education

As a result of the recent geographical changes within the hospitals of the University of Toronto Department of Obstetrics & Gynaecology, the CME Division has become creative in terms of its Interhospital Rounds presentation of academic programs (Appendix 4.4.1).

It was clear in my 2007 report that these joint rounds, held monthly on Friday mornings, would require video conferencing and webcasting to reach the many locations across the GTA. In 2008, we were able to work with Sunnybrook Health Sciences Centre and do live webcasting of interhospital rounds. This allowed physicians to log onto the webcast from either a private computer or large screens in auditoriums and participate in these events. Questions were sent by email to the moderator, and they were recognized as Category 1 teaching hours through the Royal College.

However, the “live” rounds were held at Women’s College Hospital, and once the Department moved to Sunnybrook we were able to do live broadcasts from different locations in the city with live video feeds to as many hospitals as required. This successful program has allowed us to broadcast interhospital rounds throughout the teaching hospital system in our Department, and has allowed live interaction amongst sites. The webcasts have been well received, successful and allowed us to continue these important educational activities.

The Department of Obstetrics & Gynaecology has continued to sponsor many exciting CME events over the past few years through the University of Toronto, Mount Sinai Hospital, St. Michael’s Hospital and Sunnybrook Health Sciences Centre. (Appendix 4.4.2) The events have been well received, well attended, nominated and received many CME awards for outstanding programs and are always anticipated eagerly by attendees.

Respectfully submitted, Fay Weisberg MD June, 2012 Cyclical Review Fall 2012 Self-Study 48

APPENDIX 4.4.1 Department of Obstetrics & Gynaecology CME COURSES FOR 2007

Course Title Proposed Date Venue Medical Course Target Audience Director Obstetrical Malpractice: A Saturday January 27 2007 Northrop-Frye Dan Farine Family Doctors Auditorium Ob/Gyn Survival Guide for 2007 Victoria College Nurses Midwives Lawyers

Paediatric/Adolescent Saturday February 10, 2007 JJR MacLeod Lisa Allen Gynaecologists Auditorium Family Physicians Gynaecology Review Day Nurses

Obstetric Ultrasound: February 16 – 18, 2007 Marriott – Eaton’s Greg Ryan Ob/Gyn Centre Shia Salem Radiologist Setting the Standard for Phyllis Glanc Sonographers 2007 Rory Windrim Nurses

Cervical Cancer Friday April 13, 2007 MaRS Auditorium Joan Murphy Family Physicians Ob/Gyn Prevention and Control: Nurses Transition to a New Paradigm

Mature Women’s Health Friday April 27, 2007 JJR MacLeod Harold Drutz Family Physicians Auditorium Wendy Wolfman Ob/Gyn Care: How to Grow Old Nurses Better

Refresher in Primary Friday May 11 – Isabel Bader Refresher Family Doctors Saturday May 12, 2007 Theatre, Committee Nurses Maternity Care: A Victoria College Midwives National Perspective Ob/Gyn

15th Annual Symposium – Wednesday May 16, 2007 JJR MacLeod David Chitayat Genetic Counsellors Auditorium Geneticists New Developments in Obstetricians Prenatal Diagnosis

Clinical Evaluation and Friday June 8, 2007 JJR MacLeod Ellen Greenblatt Family Physicians Auditorium Gynaecologists Treatment of Infertility Nurses

Medical Disorders in November 17, 2007 Northrop Frye Mathew Sermer Internists Auditorium Cindy Maxwell Family Physicians Pregnancy Nurses Ob/Gyn

3rd Annual Gynaecology December 7, 2007 Ben Sadowski Paul Bernstein Family Doctors Auditorium Nurses Review Day Ob/Gyn

Department of Obstetrics & Gynaecology Post-Graduate Continuing Medical Education Program for 2008 (Ten programs – 14.5 days)

Course Title Date Venue Dept. of Ob/Gyn Target Audience Medical Course Director(s) 4th Annual Saturday January 19 Northrop-Frye Dan Farine Family Doctors Obstetrical Malpractice: Auditorium Ob/Gyn Victoria College Nurses A Survival Guide for Midwives 2008 Lawyers Risk Management

11th Annual Friday February 22 - Marriott – Eaton’s Greg Ryan Ob/Gyn Advances in Centre Rory Windrim Radiologist Sunday February 24 Sonographers Gynaecological Imaging Nurses and First Trimester Ultrasound

4th Annual Friday April 25 JJR MacLeod Harold Drutz Family Physicians Mature Women’s Health Auditorium Wendy Wolfman Ob/Gyn Nurses Care: How to Grow Old Internists Better

6th Annual Friday May 9 Northrop Frye John Kingdom Family Doctors Refresher in Primary Auditorium Rory Windrim Nurses Midwives Maternity Care Ob/Gyn

16th Annual Symposium Wednesday May 14 JJR MacLeod David Chitayat Genetic Counsellors New Developments in Auditorium Geneticists Obstetricians Prenatal Diagnosis Nurses

Infectious Diseases in Friday June 6 JJR MacLeod Paul Bernstein Family Physicians Auditorium Obstetricians Obstetrics and Nurses Gynaecology

Advances in Female Thursday July 10- The Sutton Place Harold Drutz Gynaecologistss Hotel Nurses Pelvic Medicine and Saturday July 12, Urogynaecologists Reconstructive Pelvic 2008 Urologists Surgery Colorectal Surgeons

Fetal Medicine Update Friday October 24- Ben Sadowski Greg Ryan/ Radiologists Auditorium - MSH John Kingdom Ob/Gyns for 2008 Saturday 25 2008 Sonographers Paediatrcians/Neonatologists Nurses

Challenges in Saturday November 8 Ben Sadowski Knox Ritchie/ Family Doctors who do OB Auditorium - MSH Gareth Seaward Nurses IntrapartumCare Ob/Gyn

4th Annual Friday November 14 Ben Sadowski Paul Bernstein Family Doctors Gynaecology Review Auditorium - MSH Nurses Ob/Gyn Day

Department of Obstetrics & Gynaecology Continuing Medical Education Schedule 2009

Course Title Proposed Date Venue Medical Course Target Audience Director 5th Annual Saturday January 17 Northrop-Frye Dan Farine FD Obstetrical Malpractice: A Auditorium Ob/Gyn Victoria College Nurses Survival Guide for 2009 Midwives Lawyers

12th Annual Friday February 13 – Toronto Marriott Greg Ryan Ob/Gyn Obstetric Ultrasound: Sunday February 15 Eaton Centre Rory Windrim Radiologist Setting the Standard for 2009 (Shia Salem Sonographers Phyllis Glanc) Nurses

5th Annual Friday April 24 JJR MacLeod Harold Drutz FD Mature Women’s Health Auditorium Wendy Wolfman Ob/Gyn Nurses Care: How to Grow Old Better

7th Annual Friday May 22 Northrop Frye John Kingdom FD Refresher in Primary Auditorium Rory Windrim Nurses (plus committee) Midwives Maternity Care Ob/Gyn

17th Annual Symposium – Wednesday May 13 JJR MacLeod David Chitayat Genetic Counsellors Auditorium Geneticists New Developments in Obstetricians Prenatal Diagnosis and Medical Genetics

Cesarean Section Update Friday November 7 Ben Sadowski Paul Bernstein Ob/Gyn Auditorium John Kingdom Nurses Rory Windrim FD who do OB

Medical Disorders in Saturday November 8 Ben Sadowski Mathew Sermer FD who do OB Auditorium Cindy Maxwell Internists Pregnancy Nurses Ob/Gyn

5th Annual Friday November 27 Ben Sadowski Paul Bernstein FD Gynaecology Review Day Auditorium Nurses Ob/Gyn

Department of Obstetrics & Gynaecology CME COURSES FOR 2010

Course Title Proposed Date Venue Medical Course Target Audience Director 5th Annual Saturday January 16 Ben Sadowski Dan Farine Family Doctors Obstetrical Malpractice: A Auditorium Ob/Gyn Nurses Survival Guide for 2010 Midwives Lawyers

13th Annual February 26 – 28 Marriott – Eaton’s Greg Ryan Ob/Gyn Women’s Imaging: Centre Shia Salem Radiologist Advances in Gynaecologic Imaging Phyllis Glanc Sonographers and First Trimester Ultrasound Rory Windrim Nurses

6th Annual Friday April 23 Isabel Bader Harold Drutz Family Physicians Mature Women’s Health Theatre Wendy Wolfman Ob/Gyn Care Nurses

8th Annual Friday May 14 Northrop Frye John Kingdom Family Doctors Refresher in Primary Auditorium Family Practice Nurses Midwives Maternity Care Ob/Gyn

18th Annual Symposium – New Wednesday May 19 Ben Sadowski David Chitayat Genetic Counsellors Auditorium Geneticists Developments in Prenatal Obstetricians Diagnosis and Medical Genetics

Fetal Medicine Update Friday October 22 – Ben Sadowski Greg Ryan Ob/Gyn Saturday October 23 Auditorium John Kingdom Radiologist Sonographers Nurses

5th Annual Friday November 5 Ben Sadowski Jackie Thomas and Family Doctors Gynaecology Review Day Auditorium Paul Bernstein Nurses Ob/Gyn

Department of Obstetrics & Gynaecology CME COURSES FOR 2011

Course Title Proposed Date Venue Medical Course Target Audience Director 7th Annual Saturday January 15 Ben Sadowski Dan Farine Family Doctors Obstetrical Malpractice: Auditorium Ob/Gyn Nurses A Survival Guide for Midwives 2011 Lawyers

3rd Saturday February 12 Mount Sinai Lisa Allen Ob/Gyn Paediatric Adolescent Hospital FD NP / Nurses Gynaecology Review Public Health Day Family Day Wknd – Feb 21 14th Annual March 4 – 6 2011 Marriott – Eaton’s Greg Ryan Ob/Gyn Obstetric Ultrasound: Centre Shia Salem Radiologist Phyllis Glanc Sonographers Setting the Standard for Rory Windrim Nurses 2011

7th Annual Friday April 8 Isabel Bader Harold Drutz Family Physicians Mature Women’s Health Theatre Wendy Wolfman Ob/Gyn Nurses Care

9th Annual Friday May 13 Northrop Frye John Kingdom Family Doctors Refresher in Primary Auditorium Family Practice Nurses Midwives Maternity Care Ob/Gyn

19th Annual Symposium Wednesday May 18 JJR MacLeod David Chitayat Genetic Counsellors New Developments in Auditorium Geneticists Obstetricians Prenatal Diagnosis and Medical Genetics

2nd Thursday June 9 – Friday Delta Chelsea Harold Drutz Ob/Gyn Advances in Female June 10, 2011 Nurses Mount Sinai Pelvic Medicine and Hospital Reconstructive Pelvic Surgery Note: Thanksgiving Oct 10 7th Annual Friday October 28 Ben Sadowski Jackie Thomas Family Doctors Everyday Gynaecology Auditorium Nurses Ob/Gyn

Pregnancy and Obesity: Friday November 11 Ben Sadowski Cindy Maxwell Ob/Gyn A Challenge in Women’s Health Auditorium Radiologist Sonographers Nurses

3rd Friday November 25 Ben Sadowski Mathew Sermer Obstetricians Medical Disorders in Auditorium Cindy Maxwell Internal Medicine Nurses Pregnancy: Critical Care Family Physicians Focus

Department of Obstetrics & Gynaecology CME COURSES FOR 2012

Course Title Proposed Date Venue Medical Course Target Audience Director 8th Annual Saturday January 21 Ben Sadowski Dan Farine Family Doctors Obstetrical Malpractice: Auditorium Ob/Gyn A Survival Guide for 2012 Nurses Midwives Lawyers Women’s Health Friday Feb 03 LiKaShing Deborah Robertson Family Doctors Ob/Gyn Symposium Nurses 15th Annual February 24 - 26 Marriott – Eaton’s Greg Ryan Ob/Gyn Women’s Imaging: Centre Shia Salem Radiologist Advances in Gynaecologic Phyllis Glanc Sonographers Rory Windrim Nurses Imaging and First Trimester U/S

8th Annual Friday April 13 Isabel Bader Harold Drutz Family Physicians Mature Women’s Health Theatre Wendy Wolfman Ob/Gyn Nurses Care

10th Annual Friday May 11 Northrop Frye John Kingdom Family Doctors Refresher in Primary Auditorium Family Practice Nurses Midwives Maternity Care Ob/Gyn

Breastfeeding Saturday May 12 Northrop Frye Michele Farrugia Family Doctors Current Research and Best Auditorium Nurses Midwives Practices Ob/Gyn

20th Annual Symposium Wednesday May 16 JJR MacLeod David Chitayat Genetic Counsellors New Developments in Auditorium Geneticists or Obstetricians Prenatal Diagnosis & Sadowski Medical Genetics Auditorium

Fetal Medicine Update Friday October 19– Ben Sadowski Greg Ryan Ob/Gyn Saturday October 20 Auditorium John Kingdom Radiologist Sonographers Nurses Cervical Cancer Friday November 09 Ben Sadowski Joan Murphy Family Physicians Auditroium Ob/Gyn Screening and Nurses Colposcopy Update

8th Annual Friday November 30 Ben Sadowski Jackie Thomas Family Doctors Everyday Gynaecology: Auditorium Nurses The Management of Common Ob/Gyn Gynaecologic Issues

Family Planning Update: Saturday December 1 Ben Sadowski Michele Farrugia Family Doctors Auditorium Nurses Managing Contraception Ob/Gyn and Peri-Abortion Care

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Appendix 4.4.2 Interhospital Rounds

Interhospital Rounds 2007-2008

September 7, 2007 Dr. Jean Chamberlain Department of Obstetrics and Gynaecology, McMaster University and Executive Director of Save the Mothers Twenty Years of Safe Motherhood around the World: The Pitfalls and the Progress

October 12, 2007 Dr. Tom Baskett Professor Emeritus Department of Obstetrics and Gynaecology Dalhousie University, Halifax, Nova Scotia Audit of Gynaecological Surgery

November 16, 2007 Dr. Karen Rosene-Montella Chief of Medicine, Department of Medicine Women and Infants Hospital Brown University, Providence, Rhode Island, USA Thrombosis and Thrombophilia in Pregnancy

December 14, 2007 Dr. Gillian Hawker Division of Rheumatology Women’s College Hospital and Director of the Multidisciplinary Osteoporosis Program Osteoporosis Update for the Obstetrics and Gynaecology Practitioner

January 11, 2008 Dr. Isabella Caniggia Department of Obstetrics and Gynaecology Mount Sinai Hospital University of Toronto A Story of Life and Death: Pre-Eclampsia and IUGR as Distinct Pathologies

January 25, 2008 Dr. Jeffrey Wilkinson Co-Director, Duke Center for Minimally Invasive Gynecologic Surgery Duke University Medical Center, Durham, North Carolina, USA Obstetric Fistula

June 13, 2008 Dr. Curt Burger Gynecologic Oncologist Erasmus Medical Centre, Rotterdam, Amstelveen, The Netherlands Subfertility, Endometriosis, IVF and the Risk of Breast and Gynecologic Cancer: A Dutch Nationwide Study with a Follow-up of 14 years

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Interhospital Rounds: 2008-2009

September 19, 2008 Dr. Janet Rowan Joint Rounds with Endocrinology Gestational Diabetes – our future health and role of metformin

October 24, 2008 Dr. Charles Rodeck Is the Fetus a Patient?

November 14, 2008 Dr. Garnett Anderson Menopausal Hormone Therapy and Chronic Disease: An Update from the Women’s Health Initiative

December 11, 2008 Dr. Kellie Murphy Multiple Courses of Antenatal Corticosteroids For Preterm Birth Study (MACS)

January 16, 2009 Dr. Mark Walker Perinatal Surveillance and Health Services Research

February 13, 2009 Prof. Jacques Abramowicz Bioeffects and Safety of Ultrasound or: Is Ultrasound Safe for my Baby?

March 6, 2009 Dr. Bruno J. van Herendael Office Hysteroscopy in Contemporary Gynecology

April 3, 2009 Dr. Frank Chervenak Ethics: An Essential Dimension of Perinatal Medicine

May 8, 2009 RESEARCH DAY

May 22, 2009 Dr. Susan Bewley Older Mothers: Naming and Counting the Health Issues

June 12, 2009 Dr. Mathew Sermer Medical Disorders in Pregnancy. How are we doing?

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Interhospital Rounds: 2009-2010

September 18, 2009 Dr. Alan Thornhill Scientific Director, The London Bridge Fertility Gynaecology and Genetics Centre, London, UK Advances in PGD/PGS

October 9, 2009 Dr. Michael Ross Combined, Endocrinology & ObGyn Professor & Chair of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Geffen School of Medicine Developmental Programming of Metabolic Syndrome

October 30, 2009 Dr. Norman Boyd Senior Scientist, Ontario Cancer Institute Professor of Medicine, University of Toronto Breast Tissue Composition and Breast Cancer Risk

November 6, 2009 Dr. Raymond Powrie Professor of Medicine, Obstetrics and Gynecology Warren Alpert Medical School, Brown University Senior Vice President, Quality and Clinical Effectiveness, Women & Infants Hospital of Rhode Island Medical Causes of Maternal Mortality and What to Do About Them

December 4, 2009 Dr. Richard Reznick APOG - Cannell Lecture RS McLaughlin Professor & Chair Professor of Surgery, University of Toronto Vice President of Education, University Health Network It's Not About the "Competencies”, It’s About Curricular Revolution

January 15, 2010 Dr. Barry Rosen Division Head of Gynaecologic Oncology, University of Toronto Head, Division of Gynaecologic Oncology, University Health Network Cervical Cancer: Can We Make a Difference in Kenya?

February 12, 2010 Dr. Rory Windrim & Dr. Richard Pittini Department of Obstetrics & Gynaecology University of Toronto Simulation in OB/Gyn: Here, There and Everywhere

March 12, 2010 Dr. Ilan E Timor-Tritsch Professor, Department of Obstetrics and Gynaecology, New York University, Langone Medical Center Is Caesarean Scar Pregnancy Pandemic These Days?

April 9, 2010 Dr. Timothy Rowe Associate Professor, Division Head, Reproductive Endocrinology & Infertility, UBC Centre for Reproductive Health What Is a Good Doctor and How Do We Make One?

April 30, 2010 Dr. Al Yuzpe Co-Founder and Co-Director, Genesis Fertility Centre, Vancouver, BC Elective Single Embryo Transfer (eSET)

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May 7, 2010 RESEARCH DAY

June 11, 2010 Dr. Michael Kaufmann Director, Physician Health Program, Ontario Medical Association Our Health Matters: Responding to Physicians in Need.

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Interhospital Rounds: 2010-2011

September 17, 2010 Dr. Wendy Levinson Sir John and Lady Eaton Professor and Chair Department of Medicine, University of Toronto “Challenging Communication Between Surgeons and Patients: What the evidence shows”

October 15, 2010 Dr. Marcus Bernardini Dr. Guylaine Lefebvre St. Michael's Hospital/University Health Network “Robotic Surgery in Gynaecology: The Toronto Experience to Date”

November 12, 2010 Dr. Farida Jeejeebhoy Division of Cardiology - University Health Network/Mount Sinai Hospital “Management of Cardiac Arrest in Pregnancy: 2010 Guidelines"

December 3, 2010 Dr. Roberto Romero Chief, Perinatology Research Branch Program Director for Obstetrics and Perinatology, Division of Intramural Research of NICHD/NIH Professor of Molecular Obstetrics and Genetics, Wayne State University “The role of intra-amniotic infection/inflammation in pre-term labour and fetal injury”

January 7, 2011 Dr. Steven Narod Professor, University of Toronto Canada Research Chair in Breast Cancer Women’s College Research Institute, Familial Breast Cancer Research Unit “Inherited Susceptibility to Ovarian Cancer: Clinical and Public Health Implications”

February 4, 2011 Dr. Michael Divon The Hugh RK Barber MD Chairman Department of Obstetrics and Gynaecology Lenox Hill Hospital, New York “Intrauterine Growth Restriction"

March 4, 2011 Professor Ray Garry University of Western Australia (Ret.) “Watching Endometrium Grow”

Friday, April 1, 2011 Professor Catherine Williamson Imperial College, UK “Cholestasis of Pregnancy”

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May 6, 2011 RESEARCH DAY

June 3, 2011 Dr. John Kingdom Obstetrician, Maternal-Fetal Medicine, Mount Sinai Hospital Professor, Obstetrics & Gynaecology, Lab Medicine & Pathobiology, Medical Imaging, University of Toronto “Heparin and Placental Complications in Pregnancy”

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Department of Obstetrics and Gynaecology 2011-12 Interhospital Rounds, University of Toronto

Presenter Date Location Dr. Suzan Schneeweiss Fri, Sept 9, 2011 Sunnybrook Health Sciences Centre The New Royal College Maintenance of Certification Program Dr. Hans Peter Dietz Fri, Sept 23, Pelvic Floor Imaging: What's in it for the Sunnybrook Health Sciences Centre 2011 clinician? Dr. Laura Magee Fri, Oct 28, 2011 Mount Sinai Hospital The Control of Hypertension in Pregnancy Dr. Carol Townsley Fri, Nov 18, The PMH & WCH After Cancer St. Michael's Hospital 2011 Treatment Transition Initiative: ACTT Dr. Dorothy Shaw The Association of Academic Professionals APOG/Cannell Lecture in Obstetrics & Gynaecology - APOG/Cannell Lecture Competency in Global Women's Fri, Dec 2, 2011 Health: Training Needs And Marriot Hotel, Eaton Centre, 525 Bay Opportunities Street, Toronto Dr. Stephen Lye Developmental Origins of Health and Fri, Jan 13, 2012 Sunnybrook Health Sciences Centre Disease Dr. Mary Anne Jamieson Fri, Feb 3, 2012 Mount Sinai Hospital Adolescent Menometrorrhagia: Lessons from the Women and Bleeding Disorders Clinic Dr. Malcolm G. Munro Abnormal Uterine Bleeding in the Fri, Mar 2, 2012 St. Michael's Hospital Reproductive Years: The FIGO response to a professional challenge Dr. Andrea Jurisicova Aging female gametes - what can we do Fri, Apr 20, 2012 Sunnybrook Health Sciences Centre about it? U of T, JRR Macleod Auditorium & Stone Research Day - No Rounds Fri, May 4, 2012 Lobby, Medical Sciences Building, 1 King's College Circle Dr. Kevin Imrie Sunnybrook Health Sciences Centre Fri, Jun 8, 2012 Resident Duty Hours: Is Surgery Different? (changed from St. Michael's Hospital)

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4.5 Professional Development Faculty Development Committee

Faculty development is a major priority for the Department and, to this end, the Faculty Development Committee was formed in 2006, with a view to supporting and enhancing the academic career development of all faculty within the Department of Obstetrics and Gynaecology.

The current membership of the committee is Dr. J Blake (Chair), Dr. F Meffe, Dr. R Pittini, Dr. J Shime, Dr. J Thomas, Dr. A Brown, Dr. N Caccia and Dr. J Bodley. The overarching goals of the committee are to develop the full potential of faculty, to value what we do best, where we do it, and skills development.

The goals of the Faculty Development Committee were further defined by, and aligned with, the Strategic Plan of the Department in 2009 under Strategic Direction 4: Recognize, value and develop our faculty : 4-1 Increase faculty affiliation and value to the University 4-2 Recruit and retain top quality faculty 4-3 Enhance mentorship programs

The current faculty development activities within the Department include: 1. Three Year reviews – we are currently evaluating the process. 2. Faculty Recognition and Awards – A new award for Master Teacher was established in 2008. 3. Promotions with initiative including: a. Coaching to success philosophy, mentorship for preliminary applicants b. Establishment of a Teacher Evaluation Subcommittee of the Promotions Committee, chaired by Dr. R Pittini – Since 2007, for Faculty at a Professorial rank, there have been 14 promotions to Associate Professor and 7 promotions to Full Professor.

Other activities of the Faculty Development Committee include:

1. Annual Faculty Development Half-Day sessions 2. Promotions workshop, delivered annually, to facilitate understanding and preparation for promotions 3. Three year review preparation workshops 4. Encouraging identification of mentors and coaches for all new faculty recruits

New activities planned for 2012-2013 include: 1. Development of a Faculty mentorship programme ( initiated Spring 2012) 2. Addition of Community Hospital members to Faculty Development committee 3. Needs assessment and orientation package for new recruits

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Cyclical Review Fall 2012 Self-Study

4.5.1 Appendix: Faculty Development Workshops

DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY 92 College Street, Toronto ON M5G 1L4 * * * PROGRAM * * *

HALF-DAY FACULTY DEVELOPMENT & CELEBRATORY DINNER Thursday, October 11, 2007 2:00 PM Vaughan Estate, 2075 Bayview Avenue

2:00 Welcome Dr. A. Bocking

2:10 The Trainee in Difficulty, Failing Dr. Heather Shapiro Trainees and Providing Remediation

3:00 workshops A. Surgical Teaching in the Real World Drs. Nicholas Leyland and Artin (choose one of A or B) Ternamian coffee in breakout rooms

B. Teaching IMGs Drs. Adrian Brown and Maureen Gottesman

4:00 workshops A. Promotions Drs. Jennifer Blake and Richard (choose one of A or B) Pittini coffee in breakout rooms

B. Grant Writing Dr. Stephen Lye

5:00 Keynote Address Dr. Wendy Levinson Title: Teaching about Chair, Dept of Medicine Quality Improvement and Patient Safety University of Toronto

6:00 Cocktails 7:00 Dinner & Awards Presentation PROGRAM

Faculty and Alumni Professional Development Workshop and Celebratory Dinner Wednesday, October 15, 2008 2:00 PM

Department of Obstetrics and Gynecology University of Toronto, Faculty of Medicine Hart House 7 Hart House Circle, Toronto, ON M5S 3H3

Note: Each 1-hour session below will include 30-40 minutes for QA and Discussions.

Time Activity Speaker

2:00 PM Welcome SPEAKER

2:10 PM Title: Giving and Receiving Feedback Dr. Ivan Silver (All Participants)

A. Distributed Education Dr. Adrian Brown 3:00 PM Workshops B. Preparing for International Dr. David Caloia and Work Dr. Rachel Spitzer

A. Use of Simulations in Dr. Richard Pittini and 4:00 PM Education Dr. Rory Windrim Workshops coffee in B. Working in a Low Dr. Heather Morris breakout Resource Country rooms Keynote Address: 5:00 PM Dr. Andre Lalonde Title: International Women’s Health: The role of Obstetricians and Gynecologists (All Participants)

6:00 PM Cocktail Reception

7:00 PM – Dinner and Awards Presentation 10 PM

FACULTY PROFESSIONAL DEVELOPMENT DAY Workshops & Awards Presentation

Wednesday, October 13, 2010 11:45 am - 5:00 pm

The Vaughan Estate - Courtyard Ballroom, 2075 Bayview Avenue, Toronto

11:45 am - 12:45 pm Buffet Luncheon

12:45 - 1:10 pm Welcome and Awards Presentation Dr. Alan Bocking

1:10 - 2:00 pm Lecture: Expand and Multiply: How are we going to integrate education across teaching sites? Dr. Sarita Verma

2:15 - 3:10 pm A. New Promotions Guidelines Workshops Drs Jennifer Blake & Richard Pittini (choose A or B)

Coffee and refreshments in breakout rooms B. Lectures that Sizzle Drs Adrian Brown & Rick Penciner

3:15 - 4:10 pm C. Using eMedicine and Technology in Practice Workshops Dr. Karen Glass (choose C or D)

Coffee and refreshments in breakout rooms D. Fostering and Mentoring Research with Trainees Dr. Ted Brown

4:15 - 5:00 pm KEYNOTE SPEAKER: Dr. Kaveh Shojania on Thinking About Medical Error and Patient Safety in Daily Practice

FACULTY PROFESSIONAL DEVELOPMENT DAY Workshops & Awards Presentation

Wednesday, October 26, 2011 11:45 am - 6:00 pm

The Vaughan Estate - Courtyard Ballroom, 2075 Bayview Avenue, Toronto

Buffet Luncheon 11:45 – 12:45

12:45 - 1:10 pm Welcome and Awards Presentation Dr. Alan Bocking

1:10 - 2:00 pm LECTURE: Undergraduate Medical Education: Getting Ready for Accreditation Dr. Martin Schreiber

2:15 - 3:10 pm A. Social Responsibility: What is our role? Workshops Drs Alan Bocking/ Barry Pakes/ Ms. Vicki Van Wagner (choose A or B)

Coffee and refreshments B. Clerkship Matters: Why we need to know about T-RES in breakout rooms Dr. Filomena Meffe

3:15 - 4:10 pm C. Career Development: Promotion Preparation Workshop Workshops Drs Lisa Allen/ John Kingdom/ Richard Pittini (choose C or D)

Coffee and refreshments D. Collegial Conversations in breakout rooms Dr. Janet Bodley

4:15 - 5:00 pm KEYNOTE SPEAKER: Dr. Matt Gysler - The View from Mississauga

5:00 – 6:00 pm Social Gathering Register online now: http://www.obgyn.utoronto.ca/faculty/events/fpdd.htm

Rev Oct 1, 2011

APPENDIX 4.5.2 DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY Faculty of Medicine, University of Toronto LEADERSHIP COUNCIL PRESENTATIONS July 1, 2007 – June 30, 2012

Date Location Speaker Presentation

Mary Yates May 17, M.Ed., Director, Physician Workplace “Ain’t Misbehavin" – The OMA Physician Workplace Support 2012 SMH Support Program (Physician Health Program

Program), Ontario Medical Association

Dr. Mara Goldstein Staff Psychiatrist, St. Michael's Hospital; January 19, MSH Director of Undergraduate Electives, Generation Google: Issues Relevant to Today's Youth 2012 Faculty of Medicine, University of Toronto

Dr. Richard Pittini 1) Update on Developing Benchmarks May 19, Director, Undergraduate Medical SMH 2) Faculty and Program Evaluation 2011 Education Evaluation, Faculty of Medicine, U of T

Dr. Kellie Leitch Paediatric Orthopaedic Surgeon Associate Professor, Faculty of Medicine University of Toronto January 20, Chair, Ivey Centre on Health Innovation MSH Health Innovation and Commercialization 2011 and Leadership Richard Ivey School of Business University of Western Ontario Chief of Surgical Services, Lakeridge Health

APPENDIX 4.5.2 DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY Faculty of Medicine, University of Toronto LEADERSHIP COUNCIL PRESENTATIONS July 1, 2007 – June 30, 2012

Dr. Jennifer Blake Vice-Chair, Department of Obstetrics and Faculty Development Goals 2011 Gynaecology, University of Toronto

Strategic Planning Objectives: Alumni Relations, Strategic Dr. Alan Bocking Directions, Faculty of Medicine Benchmarking, Research Chair, Department of Obstetrics and Activity, Knowledge Translation/Application, Education by Gynaecology, University of Toronto Program

Dr. Heather Shapiro Director of Postgraduate Medical Education, Department of Obstetrics and Gynaecology, U of T, and May 20, SMH Education Directions 2010 Dr. Filomena Meffe Director of Undergraduate Medical Education, Department of Obstetrics and Gynaecology, U of T

Dr. Nan Okun Associate Professor, Department of Social Responsibility Obstetrics and Gynaecology

Dr. Ed Etchelles Patient Safety Centre for Patient Safety

APPENDIX 4.5.2 DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY Faculty of Medicine, University of Toronto LEADERSHIP COUNCIL PRESENTATIONS July 1, 2007 – June 30, 2012

Dr. Jennifer Blake January 21, WCH Vice-Chair, Department of Obstetrics and New Faculty Promotion Guidelines 2010 Gynaecology, University of Toronto

Dr. Stephen Lye Associate Director Focus on Research: DOHAD Samuel Lunenfeld Research Institute Mount Sinai Hospital

June 11, Facilitator: Ms. Helena Axler Leadership Council Strategic Planning Retreat Day: 89 Chesnut 2009 Fostering Integration and Collaboration

Dr. Alan Bocking Chair, Department of Obstetrics and Our Environment/ Integration and Partnerships Gynaecology, University of Toronto

Dr. Sarita Verma Our Faculty/Faculty of Medicine’s strategic plan alignment Sarita Verma, Deputy Dean, Faculty of with the Department of Obstetrics and Gynaecology Medicine Vice-Dean, Postgraduate

Medical Education University of Toronto

APPENDIX 4.5.2 DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY Faculty of Medicine, University of Toronto LEADERSHIP COUNCIL PRESENTATIONS July 1, 2007 – June 30, 2012

VPs of Research, affiliated hospital sites and Vice-Chair of Research, Faculty of Medicine:

James Woodgett, Mount Sinai, SLRI; Andreas Laupacis, St. Michael’s – LKSKI; Our Research Partners: Translational Research/Knowledge

Chris Paige, University Health Network Translation Research Institute;

Michael Julius and John Barrett, Sunnybrook – SRI; and

Peter Lewis, Faculty of Medicine

Dr. Adrian Brown, Director Distributed Our Education Partners/Expansion and communication Medical Education, Faculty of Medicine

Dr. Kathryn Parker, Educator/Evaluator, Evaluating our Progress/Research, education and The Learning Institute, Hospital for Sick benchmarking Children

Dr. Alan Bocking Strategic Planning: Focus on recommendations of the May 21, SMH Chair, Department of Obstetrics and recent External Review as a guide to moving forward 2009 Gynaecology, University of Toronto

Dr. Alan Bocking January 22, Strategic Planning WCH Chair, Department of Obstetrics and 2009 Gynaecology, University of Toronto

APPENDIX 4.5.2 DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY Faculty of Medicine, University of Toronto LEADERSHIP COUNCIL PRESENTATIONS July 1, 2007 – June 30, 2012

Dr. Alan Bocking Strategic Planning: Focus on recommendations of the May 22, Chair, Department of Obstetrics and recent External Review as a guide to moving forward 2008 Gynaecology, University of Toronto

Dr. Jeff Wilkinson January 24, Assistant Professor of Obstetrics and WCH Global Health – Obstetric Fistulas 2008 Gynecology and Global Health Duke Global Health Institute

Dr. Adrian Brown October 25, Distributed Medicine MSH Director Distributed Medical Education, 2007 Faculty of Medicine

Dr. Alan Bocking Chair, Department of Obstetrics and Gynaecology, University of Toronto, and How Continuing Education Fits in with Faculty Development

Dr. Jennifer Blake Vice-Chair, Department of Obstetrics and Gynaecology, University of Toronto

MSH = Mount Sinai Hospital SMH = St. Michael's Hospital U of T = University of Toronto WCH = Women's College Hospital

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5. Research

Introduction

The Department of Obstetrics and Gynaecology has developed into one of the most active and respected integrated clinical/research programs within North America and internationally. The current Chair, through recruitment, the creation of a supportive environment, and fostering research mentorship for trainees, has continued and expanded the foundations laid down by previous chairs, Drs Walter Hannah and Knox Ritchie.

The spectrum of research within the Department is multidisciplinary, with interests in biomedical, clinical, population-based and health outcomes/policy and translational research and engaging all divisions: Gynaecologic Oncology, Maternal-Fetal Medicine, Paediatric and Adolescent Gynaecology, Reprodutive Endocrinology and Infertility and Urogynaecology. Research is conducted within each of the hospital departments affiliated with the University of Toronto. Department investigators have been highly successful in gaining peer-review research support from granting agencies, such as the Canadian Institutes of Health Research. The Department is particularly strong in Discovery and Clinical Research within the Women’s and Infant’s Health Program at Mount Sinai Hospital and its Samuel Lunenfeld Research Institute (SLRI), the Women and Babies Program at Sunnybrook Health Sciences Centre, and the Keenan Research Centre at St Michael’s Hospital. In addition, the Department contributes to epidemiologic and clinical trials research within the University of Toronto Centre for Mother, Infant and Child Research based at the Sunnybrook Research Institute. The success of these programs (including the recruitment of key faculty and the provision of research space) is due to the strong collaboration and cooperation developed between the University Department of Obstetrics and Gynaecology, the hospital Departments of Obstetrics and Gynaecology and the hospital Research Institutes.

The Research Program

The current Chair has created a climate that is highly supportive of research.

Clinical research takes place in every hospital and all clinical members of the department contribute in some way to the research effort by reporting observations that lead to experimentation in the clinical setting or to practice change, by contributing clinical expertise to the design of studies, by leading collaborative clinical investigations, or by encouraging patients and trainees to participate in research. Investigators have taken advantage of the availability of one of the largest and most complex clinical case loads, certainly in Canada and possibly the world, to conduct their research.

Recently, led by Dr Alan Bocking, Mount Sinai Hospital has established the Ontario Birth Study (OBS), a unique open cohort, which will offer every woman seeking antenatal care at Mount Sinai Hospital the opportunity to participate in an observational study of pregnancy health. The OBS collects longitudinal biospecimens, clinical data and questionnaire data throughout the pregnancy and makes this available to researchers within and outside the Department of Ob/Gyn. Once fully operational, we anticipate that the OBS will represent the largest open cohort study in Cyclical Review Fall 2012 Self-Study 52

the world. As it is integrated into the normal program of clinical care, the OBS is designed to be implemented at other hospitals within the University of Toronto system, across Ontario and beyond. For example, we are currently exploring opportunities for OBS-harmonized cohorts in Calgary, Perth (Australia) and Shenzhen, China. Longer term, we are developing mechanisms to follow the children through infancy and childhood as part of an infrastructure within the Fraser Mustard Institute for Human Development at the University of Toronto.

Department activity in the area of Gynaecologic Oncology is providing exciting new research and national leadership in the areas of survivorship, robotics, global health, cervical cancer screening, serum banking for patients with ovarian cancer and hereditary ovarian/breast cancer, and development of synoptic reporting. Many of these initiatives bridge the gap between clinical and basic science, providing the tools for both clinicians and scientists to collect and analyze data and improve outcomes.

The majority of the discovery research component of the Department takes place within, or associated with, the Samuel Lunenfeld Research Institute at Mount Sinai Hospital, with strong individual programs at Sunnybrook HSC. The SLRI program has widened to include the range of Ob/Gyn interests, from reproductive endocrinology, fertilization and early embryo development, fetal and placental development, preterm birth, the developmental origins of health and disease, as well as mature women’s health in the areas of menopause and pelvic floor function. This group includes PhD investigators and clinical scientists within the SLRI who are recognized to be at the leading edge of research within their respective areas of interest. This includes Drs. Adamson, Bocking, Brown, Caniggia, Casper, Jurisicova, Kingdom, Lye, Nagy and Rogers. Primary appointed faculty conducting biomedical research at other locations include Drs. Librach and Nevo (Sunnybrook).

The Department has actively sought to enhance its research capability through the recruitment of key faculty as cross-appointees. As examples in the biomedical research area, cross-appointees include Drs. Belsham (Physiology), Matthews (Physiology), Letarte (Immunology), Rossant (Molecular and Medical Genetics) and Weksberg (Paediatrics). Clinical research is supported by many cross-appointees with the University of Toronto, including Drs. Asztalos (Paediatrics), Ray (Medicine), Chitayat Paediatrics), Narod (Public Health Sciences) Stewart (Psychiatry) and Colgan (Laboratory Medicine and Pathobiology). The recruitment of Drs Shoo Lee (Paediatrics) and Lyle Palmer (Public Health) to the University of Toronto has enhanced the Department’s research in population and health services research.

The Chair has contributed significantly to the continued success of these research programs through a number of mechanisms, including the direct departmental support for protected time of clinical faculty and salary support for PhD faculty, the initiation of research pilot project support and support for trainees, particularly clinical trainees. These efforts give substantial assistance to young investigators and clinical trainees to become engaged in research.

The Chair has also been very supportive of emerging research areas within the department, including Pelvic Floor Disorders, the Law and Reproductive Health, Health Policy Research, Education Research and Global Health Research (notably through support of the AMPATH network). Cyclical Review Fall 2012 Self-Study 53

The attached documentation on faculty research publications and peer-review funding provides evidence of the success of the research program (See Appendices 5.1, 5.2 and 5.3). Primary- appointees hold significant peer-review salary awards, including Canada Research Chairs (Lye, Jurisicova) and personal chairs (Bocking, Kingdom, Lefebvre, Lye, Murphy (Joan)). Department faculty members are recipients of major national and international research honours. Researchers within the department have been successful in translation of research both into improved clinical practice and through commercialization of research findings.

Research and Training

One of the most rewarding aspects of the Department’s research environment is the remarkable cadre of trainees, both at the clinical and basic science level, and trainee success in research programs and peer-review support. Our trainees (both clinical and basic science) have had remarkable success in CIHR stipend competitions and PSI (an Ontario Research Foundation) projects and stipend support. Trainees have presented at plenary sessions of the Annual SGI Meeting, as well as numerous oral sessions of national and international conferences, often receiving trainee awards.

One of the highlights of the academic year is the Annual Department Research Day. This day showcases the research undertaken by our clinical and basic science trainees. On average, 75 abstracts are presented either in oral or poster sessions each year – a remarkable testament to the research vitality of our department.

The research community within the Department has also worked closely with other department committees to integrate research into training and faculty development. In particular, the Research and Postgraduate Education Committees have worked closely to enhance research opportunities for residents. For example, we have established a group of research mentors to help residents in the early stages of their training access research projects/supervisors. We have also recently developed a graduate course that integrates science and clinical practice in the area of reproductive medicine. The goal of this course is to build bridges between science and clinical trainees. Clinical trainees are provided with a scientific basis for clinical practice, while science trainees receive an understanding of the clinical aspects of reproductive biology. These and other measures have increased the of exposure of residents and fellows to research opportunities over the past 5 years – this is apparent from the strong performance of clinical trainees in the annual Research Day and in submissions for peer-review funding and presentations at national/international conferences.

Cyclical Review Fall 2012 Self-Study 54

Research Opportunities

This is a very exciting time for research in Obstetrics and Gynaecology. Knowledge of disease mechanisms underlying reproductive disorders (e.g. endometriosis, reproductive cancers, early pregnancy loss, preeclampsia, preterm birth and pelvic floor disorders) is rapidly increasing and methods to diagnose and treat them may be within sight. Our Department is well positioned to take advantage of new opportunities provided by large-scale genome analyses. We have developed numerous collaborations with researchers nationally and internationally to provide access to patient populations and for discovery studies and clinical trials research. With the Chair’s support, we have established the Ontario Birth Study (see above), which will be a major research resource for our investigators and help the move towards the full integration of research into clinical practice. Linkage of the OBS with the Ontario Health Study (led by cross- appointee, Dr Lyle Palmer) provides further significant opportunities for our research faculty.

The Department continues to review the research landscape to ensure that it remains at the leading edge of investigation. During the Chair’s tenure, the Department developed a strategic plan for research. One of the key priorities was the “Developmental Origins of Health and Disease”, which was recognized as an important opportunity for integration within the department and with colleagues across the Faculty. As a result of leadership by the Department (supported by the Chair), the University of Toronto has established an Institute for Human Development (now named the Fraser Mustard Institute for Human Development). The IHD expands the scope of DOHaD to include the impact of early-life exposures on not only health, but on learning and social functioning. The IHD is a system-wide initiative of the University of Toronto, including multiple Faculties (e.g. Medicine, Education, Arts and Science, Social Work, Nursing) and affiliated teaching hospitals. The Department plays a major role in the establishment and operation of the IHD through our research faculty and through the leadership of Dr Lye as the Executive Director of the IHD.

The Department continues to explore multiple international research collaborations, including ongoing links with the School of Women’s and Infant’s Health at the University of Western Australia, Moi University, Eldoret, Kenya, as well as several universities in China and Thailand.

With any large scale research efforts there remain challenges. Some of these are not unique to this department and include continuing issues around long-term career success for clinician scientists and stable salary support for Ph.D. scientists. At the moment peer-review research funding is strong within the Department. However, agencies such as CIHR continue to be under pressure with reduced overall success rates.

Much of the success of the Department’s research program is due to the support of the hospital- based research institutes. The institutes provide the research infrastructure andm to a large extent, salary support for research faculty within the Department. This relationship continues to be strong and supportive on both sides. However, the reliance on the research institutes does place some constraints on the research autonomy of the Department.

The Department remains cognizant of the need to strive for even greater integration of basic and clinical research. We believe that the Ontario Birth Study will be a vehicle to further this Cyclical Review Fall 2012 Self-Study 55

integration. We are also aware of the need to support research across the spectrum of Ob/Gyn. In the past 5 years, areas of reproductive medicine (REI) and urogynaecology have made significant advances in their research capacity. Thus, while the research effort of the Department remains strong, we are cognizant of the need to constantly review opportunities and tackle challenges to maintain and further enhance our research programs.

Sincerely,

Stephen J Lye Vice-Chair, Research

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5.1 Appendix: Research Publications 2007-2012

PEER-REVIEWED PUBLICATIONS 2007-2008 Original Research

Abdel-Malek N, Chiarelli A, Sloan M, Stewart DE, Mai V, Howlett R. Influence of physician and patient characteristics on adherence to breast cancer screening recommendations. Eur J Cancer Prev 2008 Feb; 17(1):48-53.

Abou-Nassar K, Kovacs MJ, Kahn SR, Wells P, Doucette S, Ramsay T, Clement AM, Khurana R, Mackinnon K, Blostein M, Solymoss S, Kingdom J, Sermer M, Rey E, Rodger M; TIPPS investigators.The effect of dalteparin on coagulation activation during pregnancy in women with thrombophilia. A randomized trial. Thromb Haemost 2007 Jul;98(1):163-71.

Acton BM, Lai I, Shang X, Jurisicova A, Casper RF. Neutral mitochondrial heteroplasmy alters physiological function in mice. Biology of Reproduction 2007 Sep;77(3):569-76.

Aggarwal A, Shier RM. Recalcitrant trichomonas vaginalis infections successfully treated with vaginal acidification. J Obstet Gynaecol Can 2008 Jan;30(1):55-8.

Akoury H, Sherman C. Uterine wall partial thickness necrosis following combined B-Lynch and Cho square sutures for the treatment of primary postpartum hemorrhage. JOGC 2008 May;30(5):421-4.

Arzola C, Balki M, Carvalho JC. The antero-posterior diameter of the lumbar dural sac does not predict sensory levels of spinal anesthesia for Cesarean delivery. Can J Anaesth 2007 Aug;54(8):620-5.

Bähring S, Kann M, Neuenfeld Y, Gong M, Chitayat D, Toka HR, Toka O, Plessis G, Maass P, Rauch A, Aydin A, Luft FC. Inversion region for hypertension and brachydactyly on chromosome 12p features multiple splicing and noncoding RNA. Hypertension 2008 Feb; 51(2):426-31.

Balki M, Dhumne S, Kasodekar S, Kingdom J, Windrim R, Carvalho JC. Oxytocin- ergometrine co-administration does not reduce blood loss at caesarean delivery for labour arrest. BJOG 2008 Apr;115(5):579-84.

Balki M, Kasodekar S, Dhumne S, Bernstein P, Carvalho JC. Remifentanil patient-controlled analgesia for labour: optimizing drug delivery regimens. Can J Anaesth 2007 Aug;54(8):626-33.

Bambao C, Rasty G, Bandarchi B, Shier M. Benign ductal hyperplasia and adenosis of mammarylike glands of the vulva. J Low Genit Tract Dis 2008 Jan;12(1):32-4.

Barbera L, Thomas G, Elit L, Covens A, Fyles A, Osborne R, Yun L. Treating vulvar cancer in the new millennium: are patients receiving optimal care? Gynecol Oncol 2008 Apr;109(1):71-5. Epub 2008 Jan 29. 2 PUBLICATIONS 2007-2008

Barua M, Hladunewich M, Keunen J, Pierratos A, McFarlane P, Sood M, Chan CT. Successful pregnancies on nocturnal home hemodialysis. Clin J Am Soc Nephrol 2008 Mar;3(2):392-6.Bates HE, Kiraly MA, Yue JT, Goche Montes D, Elliott ME, Riddell MC, Matthews SG, Vranic M. Recurrent intermittent restraint delays fed and fasting hyperglycemia and improves glucose return to baseline levels during glucose tolerance tests in the Zucker diabetic fatty rat--role of food intake and corticosterone. Metabolism 2007 Aug;56(8):1065-75.

Beck J, Brander L, Slutsky AS, Reilly MC, Dunn MS, Sinderby C. Non-invasive neurally adjusted ventilatory assist in rabbits with acute lung injury. Intensive Care Med 2008 Feb;34(2):316-23. Epub 2007 Oct 25.

Bedaiwy MA, Shokry M, Mousa N, Claessens EA, Esfandiari N, Gotlieb L, Casper RF. Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination. Fertil Steril 2008 May. [Epub ahead of print]

Beigi RH, Yudin MH, Cosentino L, Meyn LA, Hillier SL. Cytokines, pregnancy and bacterial vaginosis: comparison of cervical cytokine levels between pregnant and non-pregnant women with bacterial vaginosis. J Infect Dis 2007;196:1355-60.

Bentov Y, Casper RF. Menopause. Sex hormone receptors and testosterone in postmenopausal women. 2008 Mar-Apr;15(2):210-1.

Bergman B, Ahmad F, Stewart DE. Work family balance, stress and salivary cortisol in men and women academic physicians. Int J Behav Med 2008 Jan-Mar;15(1):54-61.

Bertram C, Khan O, Ohri S, Phillips DI, Matthews SG, Hanson MA. Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function. J Physiol 2008 Apr;586(8):2217-29.

Bishara R, Dunn MS, Merko SE, Darling P. Nutrient composition of hindmilk produced by mothers of very low birth weight infants born at less than 28 weeks' gestation. J Hum Lact 2008 May;24(2):159-67.

Black D, Levine DA, Nicoll L, Chou JF, Iasonos A, Brown CL, Sonoda Y, Chi DS, Leitao MM, Abu-Rustum NR, Ferguson SE, Barakat RR. Low risk of complications associated with the fenestrated peritoneal catheter used for intraperitoneal chemotherapy in ovarian cancer. Gynecol Oncol. 2008 Apr;109(1):39-42. Epub 2008 Jan 29

Blackmore ER, Munce SE, Weller I, Zagorski BM, Stansfeld SA, Stewart DE, Cain ED, Conwell Y. Psychosocial and clinical correlates of suicidal acts: Results from a national population survey. Br J Psychiatry 2008 April; 192:279-84.

Blackmore ER, Stansfeld SA, Weller I, Munce SE, Zagorski BM, Stewart DE. Major depressive episodes and work stress: Results from a national population survey. Am J Public Health 2007 Nov;97(11):2088-93. Epub 2007 Sep 27.

Blank V, Hirsch E, Challis JR, Romero R, Lye SJ. Cytokine signaling, inflammation, innate immunity and preterm labour - a workshop report. Placenta 2008 Mar;29 Suppl A:S102-4. Epub 2007 Dec 20.

3 PUBLICATIONS 2007-2008

Briggs TA, Abdel-Salam GM, Balicki M, Baxter P, Bertini E, Bishop N, Browne BH, Chitayat D, Chong WK, Eid MM, Halliday W, Hughes I, Klusmann-Koy A, Kurian M, Nischal KK, Rice GI, Stephenson JB, Surtees R, Talbot JF, Tehrani NN, Tolmie JL, Toomes C, van der Knaap MS, Crow YJ. Cerebroretinal microangiopathy with calcifications and cysts (CRMCC). Am J Med Genet A 2008 Jan; 146(2):182-90.

Brown R, Imran SA, Belsham DD, Ur E, Wilkinson M. Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3. Neuroendocrinology 2007;85(4):232-41. Epub 2007 Jun 19.

Burra TA, Chen E, McIntyre RS, Grace SL, Blackmore ER, Stewart DE. Predictors of self- reported antidepressant adherence. Behav Med 2007 Winter; 32(4):127-34.

Cameron JI, Cheung AM, Streiner DL, Coyte PC, Singh MD, Stewart DE. Factor structure and reliability of the brain impairment behavior inventory. J Neurosci Nurs 2008 Feb; 40(1):40-7.

Carvalho JC. Ultrasound-facilitated epidurals and spinals in obstetrics. Anesthesiol Clin 2008 Mar;26(1):145-58, vii-viii.

Carydis VB, Walker T, Wing A, Colgan TJ. Utility of p16(ink4a) immunocytochemistry in liquid-based cytology specimens from women treated for high-grade squamous intraepithelial lesions. Acta Cytol 2007 Jul-Aug;51(4):517-22.

Casper RF. Aromatase inhibitors in ovarian stimulation. J Steroid Biochem Mol Biol 2007 Aug- Sep;106(1-5):71-5. Epub 2007 May 24.

Cheng H, Isoda F, Belsham DD, Mobbs CV. Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation. Endocrinology 2008 Feb;149(2):703-10. Epub 2007 Nov 1.

Cheung A, Lee Y, Kapral M, Scher J, Ho I, Lui-Yee D, Stewart DE. Barriers and motivations for women to participate in cardiovascular trails. J Obstet Gynecol Can 2008 April; 30(4): 332-7.

Chitayat D, Shannon P, Keating S, Toi A, Blaser S, Friedberg T, Superti-Furga A, Chong K, Unger S. Raine syndrome: a rare lethal osteosclerotic bone dysplasia. Prenatal diagnosis, autopsy, and neuropathological findings. Am J Med Genet A 2007 Dec 15;143A(24):3280-5.

Dajnowiec D, Sabatini PJB, Zhang M, Langille BL. Force-induced polarized mitosis of endothelial and smooth muscle cells in arterial remodeling. Hypertension 2007;50:255-60.

Derzko C, Elliott S, Lam W. Management of sexual dysfunction in postmenopausal breast cancer patients taking adjuvant aromatase inhibitor therapy. Curr Oncol 2007 Dec;14 Suppl 1:S20-40.

DeSouza LV, Grigull J, Ghanny S, Dubé V, Romaschin AD, Colgan TJ, Siu KW. Endometrial carcinoma biomarker discovery and verification using differentially tagged clinical samples with multidimensional liquid chromatography and tandem mass spectrometry. Mol Cell Proteomics 2007 Jul;6(7):1170-82. Epub 2007 Mar 19.

4 PUBLICATIONS 2007-2008

Detmar J, Rennie MY, Whiteley KJ, Qu D, Taniuchi Y, Shang X, Casper RF, Adamson SL, Sled JG, Jurisicova A. Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR-dependent changes in cell death. Am J Physiol Endocrinol Metab Epub 2008 Jun 17.

Diaz-Granados N, Stewart DE. Using a gender lens to monitor mental health. Int J Public Health 2007;52(4):197-8.

Dong X, Sweet J, Challis JR, Brown T, Lye SJ. Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb. Mol Cell Biol 2007 Jul;27(13):4863- 75. Epub 2007 Apr 23.

Dubé V, Grigull J, DeSouza LV, Ghanny S, Colgan TJ, Romaschin AD, Siu KW. Verification of endometrial tissue biomarkers previously discovered using mass spectrometry-based proteomics by means of immunohistochemistry in a tissue microarray format. J Proteome Res 2007 Jul;6(7):2648-55. Epub 2007 Jun 7.

Dubé V, Macdonald D, Allingham-Hawkins DJ, Kamel-Reid S, Colgan TJ. Vanishing endometrial carcinoma. Int J Gynecol Pathol 2007 Jul;26(3):271-7.

Edmondson N, Bocking A, Machin G, Rizek R, Watson C, Keating S. The prevalence of chronic deciduitis in cases of preterm labour without clinical chorioamnionitis. Pediat Dev Pathol 2008;Jan 2:1. [Epub ahead of print]

Ferguson SE, Tornos C, Hummer A, Barakat RR, Soslow RA. Prognostic features of surgical stage I uterine carcinosarcoma. Am J Surg Pathol 2007 Nov;31(11):1653-61.

Fernandes BJ, von Dadelszen P, Fazal I, Bansil N, Ryan G. Flow cytometric assessment of feto- maternal hemorrhage: A comparison with Betke-Kleihauer. Prenat Diagn. 2007 Jul;27(7):641-3.

Fong KW, McInnes M, Toi A, Shannon P, Chitayat D, Blaser S. Dural sinus malformation involving the torcular: Prenatal diagnosis with ultrasound and magnetic resonance imaging. Ultrasound Obstet Gynecol 2007 Oct; 30(4):590-1.

Forman R, Gill S, Moretti M, Tulandi T, Koren G, Casper R. Fetal safety of letrozole and clomiphene citrate for ovulation induction. J Obstet Gynaecol Can 2007 Aug;29(8):668-71. Gagnon AJ, Dougherty G, Platt RW, Wahoush O, George A, Stanger E, Oxman-Martinez J, Saucier JF, Merry L, Stewart DE. Refugee and refugee-claimant women and infants post-birth: Migration histories as a predictor of Canadian health system response to needs. Can J Public Health 2007 Jul-Aug;98(4):287-91.

Gajic-Veljanoski O, Stewart DE. Women trafficked into prostitution: Determinants, human rights and health needs. Transcult Psychiatry 2007 Sep;44(3):338-58.

Gellhaus A, Schmidt M, Dunk C, Lye SJ, Winterhager E. The circulating proangiogenic factors CYR61 (CCN1) and NOV (CCN3) are significantly decreased in placentae and sera of preeclamptic patients. Reprod Sci. 2007 Dec;14(8 Suppl):46-52. 5 PUBLICATIONS 2007-2008

Gibbins S, Stevens B, McGrath P, Dupuis A, Yamada J, Beyene J, Breau L, Camfield C, Finley GA, Franck L, Johnston C, McKeever P, O'Brien K, Ohlsson A. Changes in physiological and behavioural pain indicators over time in preterm and term infants at risk for neurologic impairment. Early Hum Dev 2008 Jun 17. [Epub ahead of print]

Gien LT, Covens A. Quality control in sentinel lymph node biopsy in cervical cancer. J Clin Oncol 2008 Jun 20;26(18):2930-1.

Gortzak-Uzan L, Ignatchenko A, Evangelou AI, Agochiya M, Brown KA, St Onge P, Kireeva I, Schmitt-Ulms G, Brown TJ, Murphy J, Rosen B, Shaw P, Jurisica I, Kislinger T. A proteome resource of ovarian cancer ascites: Integrated proteomic and bioinformatic analyses to identify putative biomarkers. J Proteome Res 2008 Jan;7(1):339-51. Epub 2007 Dec 13.

Grace SL, Grewal K, Arthur HM, Abramson BL, Stewart DE. A prospective, controlled multi- site study of psychosocial and behavioral change following women’s cardiac rehabilitation participation.. J Womens Health (Larchmt). 2008 Mar;17(2):241-8.

Grace SL, Leung YW, Stewart DE. A prospective examination of antidepressant use and its correlates in patients with acute coronary syndrome. Psychosomatics 2008 May-June;49:199-207.

Gravely-Witte S, Stewart DE, Suskin N, Higginson L, Alter D, Grace SL. Cardiologists’ charting varied by risk factor, and was often discordant with patient report. J Clin Epidem 2008 October; 61(10), 1073-9.

Grisaru D, Hauspy J, Prasad M, Albert M, Murphy KJ, Covens A, Macgregor PF, Rosen B. Microarray expression identification of differentially expressed genes in serous epithelial ovarian cancer compared with bulk normal ovarian tissue and ovarian surface scrapings. Oncol Rep 2007 Dec;18(6):1347-56.

Groenman FA, Rutter M, Wang J, Caniggia I, Tibboel D, Post M. Effect of chemical stabilizers of hypoxia-inducible factors on early lung development. Am J Physiol Lung Cell Mol Physiol 2007 Sep;293(3):L557-67. Epub 2007 Jun 1.

Gucciardi E, Cameron JI, Liao CD, Palmer A, Stewart DE. Program design features that can improve participation in health education interventions. BMC Med Res Methodol 2007 Nov 9;7:47.

Gucciardi E, DeMelo M, Offenheim A, Grace SL, Stewart DE. Patient factors associated with attrition from a self-management education programme . J Eval Clin Pract 2007 Dec;13(6):913-9.

Gucciardi E, DeMelo M, Offenheim A, Stewart DE. Factors contributing to attrition behavior in diabetes self-management programs: A mixed method approach. BMC Health Serv Res 2008 Feb 4;8:33.

Gucciardi E, Wang SC, Badiani T, Stewart DE. Beyond adolescence. Exploring Canadian women and men’s perception of overweight. Women’s Health Issues 2007; 17:374-82.

Gucciardi E, Wang SC, DeMelo M, Amaral L, Stewart DE. Characteristics of men and women with diabetes: Observations during patients' initial visit to a diabetes education centre. Can Fam Physician 2008 Feb;54(2):219-27. 6 PUBLICATIONS 2007-2008

Guenter D, Barbara AM, Zlotnik Shaul R, Yudin MH, Remis RS, King SM. Prenatal HIV testing: Women’s experiences of informed consent in Toronto, Ontario. J Obstet Gynaecol Can 2008;30(1):17-22.

Gunby J, Bissonnette F, Librach C, Cowan L; IVF Directors Group of the Canadian Fertility and Andrology Society. Assisted reproductive technologies (ART) in Canada: 2004 results from the Canadian ART Register. Fertil Steril 2008 May;89(5):1123-32. Epub 2007 Aug 13.

Gunby J, Bissonnette F, Librach C, Cowan L; on behalf of the IVF Directors Group of the Canadian Fertility and Andrology Society. Assisted reproductive technologies in Canada: 2005 results from the Canadian Assisted Reproductive Technologies Register. Fertil Steril 2008 Apr 18. [Epub ahead of print]

Haider MA, Chung P, Sweet J, Toi A, Jhaveri K, Ménard C, Warde P, Trachtenberg J, Lockwood G, Milosevic M. Dynamic contrast-enhanced magnetic resonance imaging for localization of recurrent prostate cancer after external beam radiotherapy. Int J Radiat Oncol Biol Phys 2008 Feb; 70(2):425-30.

Hauspy J, Beiner M, Harley I, Ehrlich L, Rasty G, Covens A. Sentinel lymph node in vulvar cancer. Cancer 2007 Sep 1;110(5):1015-23.

Hill JL, Campbell MK, Zou GY, Challis JR, Reid G, Chisaka H, Bocking AD. Prediction of preterm birth in symptomatic women using decision tree modeling for biomarkers. Am J Obstet Gynecol 2008 Apr;198(4):468.e1-7; discussion 468.e7-9.

Hindmarsh PC, Geary MP, Rodeck CH, Kingdom JC, Cole TJ. Factors predicting ante- and postnatal growth. Pediatr Res 2008 Jan;63(1):99-102.

Hitkari JA, Singh SS, Shapiro HM, Leyland N. Essure treatment of hydrosalpinges. Fertil Steril 2007 Dec;88(6):1663-6. Epub 2007 May 9

Ho B, Hou G, Pickering JG, Langille BL, Bendeck MP. Integrin linked kinase maintains smooth Muscle cell quiescence. Am J Pathol 2008;173:278-88.

Ho V, Keating S, Kingdom J, Shannon P. Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy. Am J Surg Pathol 2007 Dec; 31(12): 1893-6.

Ismiil N, Rasty G, Ghorab Z, Nofech-Mozes S, Bernardini M, Ackerman I, Thomas G, Covens A, Khalifa MA. Adenomyosis involved by endometrial adenocarcinoma is a significant risk factor for deep myometrial invasion. Ann Diagn Pathol 2007 Aug;11(4):252-7.

Ismiil ND, Rasty G, Ghorab Z, Nofech-Mozes S, Bernardini M, Thomas G, Ackerman I, Covens A, Khalifa MA. Adenomyosis is associated with myometrial invasion by FIGO 1 endometrial adenocarcinoma. Int J Gynecol Pathol 2007 Jul;26(3):278-83.

Jaeggi E, Chitayat D, Golding F, Kim P, Yoo SJ. Prenatal diagnosis of topsy-turvy heart. Cardiol Young 2008 June;18(3):337-42. 7 PUBLICATIONS 2007-2008

Jurisicova A,Taniuchi A, Shang Y, Xu J, Detmar J, Li H, Matikainen T, Benito A, Nunez G, Casper RF. Maternal exposure to polycyclic aromatic hydrocarbons diminishes ovarian reserve in female offspring via induction of the cell death gene Harakiri. JCI 2007;117(12): 3971-8.

Kalabis GM, Petropoulos S, Gibb W, Matthews SG. Breast cancer resistance protein (Bcrp1/Abcg2) in mouse placenta and yolk sac: ontogeny and its regulation by progesterone. Placenta 2007 Oct;28(10):1073-81. Epub 2007 May 24.

Kapoor A, Petropoulos S, Matthews SG. Fetal programming of hypothalamic-pituitary-adrenal (HPA) axis function and behavior by synthetic glucocorticoids. Brain Res Rev 2008 Mar;57(2):586-95. Epub 2007 Jul 27

Kepron C, Blumenthal A, Chitayat D, Cutz E, Superti-Furga A, Keating S. An autophagic vacuolar myopathy-like disorder presenting as non-immune hydrops in a female fetus. Pediatr Dev Pathol 2008 Feb 25:1.

Khazaei M, Montaseri A, Casper RF. Letrozole stimulates the growth of human endometrial explants cultured in three-dimensional fibrin matrix. Fertil Steril 2008 Apr 8. [Epub ahead of print]

Király MA, Bates HE, Kaniuk NA, Yue JT, Brumell JH, Matthews SG, Riddell MC, Vranic M. Swim training prevents hyperglycemia in ZDF rats: mechanisms involved in the partial maintenance of beta-cell function. Am J Physiol Endocrinol Metab 2008 Feb;294(2):E271-83. Epub 2007 Nov 20.

Koenen SV, Dunn EA, Kingdom JC, Ohlsson A, Matthews SG. Overexposure to antenatal corticosteroids: A global concern. J Obstet Gynaecol Can 2007 Nov;29(11):879.

Kotsopoulos J, Librach CL, Lubinski J, Gronwald J, Kim-Sing C, Ghadirian P, Lynch HT, Moller P, Foulkes WD, Randall S, Manoukian S, Pasini B, Tung N, Ainsworth PJ, Cummings S, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group. Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: A case-control study. Cancer Causes Control 2008 Dec;19(10):1111-9. Epub 2008 May 29.

Kruck TP, Percy ME, Lukiw WJ. Metal sulfate-mediated induction of pathogenic genes and repression by phenyl butyl nitrone and Feralex-G. Neuroreport 2008 Jan:19(2): 245-9.

Langevin R, Langevin M, Curnoe S, Bain J. The prevalence of diabetes among sexual violent offenders and the co-occurrence with cognitive impairment, mania, psychotic symptoms and aggressive behaviour. Int J Prison Health 2008 Jun;4(2):83-95.

Lausman AY, Langer JC, Tai M, Seaward PG, Windrim RC, Kelly EN, Ryan G. Gastroschisis: What is the average gestational age of spontaneous delivery? J Pediatr Surg 2007 Nov;42(11):1816-21.

Lee Y, Tanaka M, Carvalho JC. Sonoanatomy of the lumbar spine in patients with previous unintentional dural punctures during labor epidurals. Reg Anesth Pain Med 2008 May- Jun;33(3):266-70.

8 PUBLICATIONS 2007-2008

Leung YW, Ceccato N, Stewart DE, Grace SL. A prospective examination of patterns and correlates of exercise maintenance in coronary artery disease patients. J Behav Med 2007 Oct; 30(5):411-21. [Epub 2007 Jul 7]

Li H, DeSouza LV, Ghanny S, Li W, Romaschin AD, Colgan TJ, Siu KW. Identification of candidate biomarker proteins released by human endometrial and cervical cancer cells using two- dimensional liquid chromatography/tandem mass spectrometry. J Proteome Res 2007 Jul;6(7):2615-22. Epub 2007 May 25.

Lovatsis D, José JB, Tufman A, Drutz HP, Murphy K. Assessment of patient satisfaction with postoperative pain management after ambulatory gynaecologic laparoscopy. J Obstet Gynaecol Can 2007 Aug;29(8):664-7.

Marshall CR, Noor A, Vincent JB, Lionel AC, Feuk L, Skaug J, Shago M, Moessner R, Pinto D, Ren Y, Thiruvahindrapduram B, Fiebig A, Schreiber S, Friedman J, Ketelaars CE, Vos YJ, Ficicioglu C, Kirkpatrick S, Nicolson R, Sloman L, Summers A, Gibbons CA, Teebi A, Chitayat D, Weksberg R, Thompson A, Vardy C, Crosbie V, Luscombe S, Baatjes R, Zwaigenbaum L, Roberts W, Fernandez B, Szatmari P, Scherer SW. Structural variation of chromosomes in autism spectrum disorder. Am J Hum Genet 2008 Jan 17; 82(2):477-88

Maslow K, Drutz H, Lovatsis D. TVT is an effective treatment for occult stress urinary incontinence in patients having vaginal repair of pelvic organ prolapse: A case series. J Pelvic Medicine and Surgery Jan/Feb 2008; 14:23-27.

McAuliffe F, Chitayat D, Halliday W, Keating S, Shah V, Fink M, Nevo O, Ryan G, Shannon P, Blaser S. Rhombencephalosynapsis: Prenatal imaging and autopsy findings. Ultrasound Obstet Gynecol 2008 May;31(5):542-8.

McDonald SD, Walker MC, Ohlsson A, Murphy KE, Beyene J, Perkins SL. The effect of tobacco exposure on maternal and fetal thyroid function. Eur J Obstet Gynecol Reprod Biol 2008 Apr 4 [Epub ahead of print]

Mettler L, Hucke J, Bojahr B, Tinneberg HR, Leyland N, Avelar R. A safety and efficacy study of a resorbable hydrogel for reduction of post-operative adhesions following myomectomy.Hum Reprod 2008 May;23(5):1093-100. Epub 2008 Mar 17.

Milosevic M, Chung P, Parker C, Bristow R, Toi A, Panzarella T, Warde P, Catton C, Menard C, Bayley A, Gospodarowicz, Hill R. Androgen withdrawal in patients reduces prostate cancer hypoxia: Implications for disease progression and radiation response. Cancer Res 2007 Jul; 67(13):6022-5.

Minassian VA, Ross S, Sumabat O, Lovatsis D, Pascali D, Al-Badr A, Alarab M, Drutz HP. Randomized trial of oxybutynin extended versus immediate release for women aged 65 and older with overactive bladder: lessons learned from conducting a trial. J Obstet Gynaecol Can 2007 Sep;29(9):726-32.

Morgan P, Pittini R, Regehr G. The use of simulation education in competency assessment: More questions than answers. Anesthesiology 2008 Jan ;108(1):168.

9 PUBLICATIONS 2007-2008

Mu J, Qu D, Bartczak A, Phillips MJ, Manuel J, He W, Koscik C, Mendicino M, Zhang L, Clark DA, Grant DR, Backx PH, Levy GA, Adamson SL. Fgl2 deficiency causes neonatal death and cardiac dysfunction during embryonic and postnatal development in mice. Physiol Genomics 2007 Sep 19;31(1):53-62.

Munce SE, Stansfeld SA, Blackmore ER, Stewart DE. The role of depression and chronic pain conditions in absenteeism: Results from a national epidemiologic survey. J Occup Environ Med 2007 Nov; 49:1206-11.

Munce SE, Stewart DE. Gender differences in depression and chronic pain conditions in a national epidemiologic survey. Psychosomatics 2007 Sep-Oct;48(5):394-9.

Nadkarni D, Spitzer RF, Colgan T, Kives S, Allen L. Uterine asymmetry and dysmenorrhea in a young woman. J Obstet Gynaecol Can 2008 Apr 30(4):301-2.

Nam RK, Toi A, Klotz LH, Trachtenberg J, Jewett MAS, Appu S, Loblaw DA, Sugar L, Narod SA, Kattan MW. Assessing individual risk for prostate cancer. J Clin Onc 2007 Aug; 25(24):3582-8.

Nam RK, Zhang WW, Loblaw DA, Klotz LH, Trachtenberg J, Jewett MAS, Stanimirovic A, Davies TO, Toi A, Venkateswaran V, Sugar L, Siminovitch KA, Narod SA. A genome-wide association screen identifies regions on chromosomes 1q25 and 7p21 as risk loci for sporadic prostate cancer. Prostate Cancer Prostatic Dis 2008;11(3):241-6. Epub 2007 Sep 18.

Nash A, Secker D, Corey M, Dunn M, O'Connor DL. Field testing of the 2006 World Health Organization growth charts from birth to 2 years: assessment of hospital undernutrition and overnutrition rates and the usefulness of BMI. JPEN J Parenter Enteral Nutr 2008 Mar- Apr;32(2):145-53.

Nevo O, Many A, Xu J, Kingdom J, Zamudio S, Post M, Bocking A, Todros T, Caniggia I. Placental expression of soluble fms-like tyrosine kinase 1 is increased in singletons and twin pregnancies with intrauterine growth restriction. J Clin Ednocrinol Metab 2008 Jan; 93 (1):285- 92.

Nevo O, Soustiel JF, Thaler I. Cerebral blood flow is increased during controlled ovarian stimulation. Am J Physiol Heart Circ Physiol 2007, 293(6):H3265-9.

Nofech-Mozes S, Ackerman I, Ghorab Z, Ismiil N, Thomas G, Covens A, Khalifa MA. Lymphovascular invasion is a significant predictor for distant recurrence in patients with early- stage endometrial endometrioid adenocarcinoma. Am J Clin Pathol 2008 Jun;129(6):912-7.

Nofech-Mozes S, Ghorab Z, Ismiil N, Ackerman I, Thomas G, Barbera L, Covens A, Khalifa MA. Endometrial endometrioid adenocarcinoma: a pathologic analysis of 827 consecutive cases. Am J Clin Pathol 2008 Jan;129(1):110-4.

Ong GK, Hamilton JK, Sermer M, Connelly PW, Maguire G, Zinman B, Hanley AJ, Retnakaran R. Maternal serum adiponectin and infant birthweight: The role of adiponectin isoform distribution. Clin Endocrinol (Oxf) 2007 Jul;67(1):108-14. Epub 2007 Apr 27. 10 PUBLICATIONS 2007-2008

Percy M, Moalem S, Garcia A, Somerville MJ, Hicks M, Andrews D, Azad A, Schwarz P, Zavareh RB, Birkan R, Choo C, Chow V, Dhaliwal S, Duda V,Kupferschmidt AL, Lam K, Lightman D, Machalek K, Mar W, Nguyen F, Rytwinski PJ,Svara E, Tran M, Wheeler K, Yeung L, Zanibbi K, Zener R, Ziraldo M, Freedman M. Involvement of ApoE E4 and H63D in sporadic Alzheimer's disease in a folate-supplemented Ontario population. J Alzheimers Dis 2008 May;14(1) 69-84.

Prasad M, Bernardini M, Tsalenko A, Marrano P, Paderova J, Lee CH, Ben-Dor A, Barrett MT, Squire JA. High definition cytogenetics and oligonucleotide aCGH analyses of cisplatin-resistant ovarian cancer cells. Genes Chromosomes Cancer 2008 May;47(5):427-36.

Quach S, Librach C. Infertility knowledge and attitudes in urban high school students. Fertil Steril. 2008 Dec;90(6):2099-106. Epub 2008 Mar 5.

Rac VE, Scott CA, Small C, Adamson SL, Rurak D, Challis JR, Lye SJ. Dose-dependent effects of meloxicam administration on cyclooxygenase-1 and cyclooxygenase-2 protein expression in intrauterine tissues and fetal tissues of a sheep model of preterm labor. Reprod Sci 2007 Dec;14(8):750-64.

Rachmiel M, Kives S, Atenafu E, Hamilton J. Primary amenorrhea as a manifestation of polycystic ovarian syndrome in adolescents: A unique subgroup? Arch Pediatr Adolesc Med 2008 Jun;162(6):521-5.

Randall IM, Costello J, Carvalho JC. Transversus abdominis plane block in a patient with debilitating pain from an abdominal wall hematoma following cesarean delivery. Anesth Analg 2008 Jun;106(6):1928.

Rennie MY, Whiteley KJ, Kulandavelu S, Adamson SL, Sled JG. 3D visualization and quantification by microcomputed tomography of late gestational changes in the arterial and venous feto-placental vasculature of the mouse. Placenta 2007 Aug-Sep;28(8-9):833-40.

Retnakaran R, Connelly PW, Sermer M, Zinman B, Hanley AJ. The impact of family history of diabetes on risk factors for gestational diabetes. Clin Endocrinol (Oxf). 2007 Nov;67(5):754-60. Epub 2007 Jul 3.

Riley DL, Stewart DE, Grace SL. Continuity of cardiac care: Cardiac rehabilitation participation and other correlates. Int J Cardiol 2007 Jul 31;119(3):326-33. Epub 2007 Jan 25.

Robertson D, Kives S. Adolescent consent in reproductive and sexual health decision-making: Should there be an arbitrary age of consent or should it be based on the ‘evolving capacities of the child’? J Pediatr Adolesc Gynecol 2008 Feb; 21(1) 47-51.

Rogers I, Harris D Umbilical cord blood: A unique source of pluripotent stem cells for regenerative medicine. Curr Stem Cell Res Ther 2007 Dec;2(4):301-9.

Rosenfeld R, Livne D, Nevo O, Dayan L, Milloul V, Lavi S, Jacob G. Hormonal and volume dysregulation in women with premenstrual syndrome. Hypertension 2008, 51(4):1225-30.

11 PUBLICATIONS 2007-2008

Rudini N, Felici A, Giampietro C, Lampugnani M, Corada M, Swirsding K, Garrè M, Liebner S, Letarte M, ten Dijke P, Dejana E. VE-cadherin is a critical endothelial regulator of TGF-ß signaling. EMBO J 2008 27(7):993-1004.

Sabatini PJB, Zhang M, Silverman-Gavrila R, Bendeck MP, Langille BL. N-cadherin regulates cell polarity during migration of vascular smooth muscle cells. Circ Res 2008;103:405-12.

Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W; Caffeine for Apnea of Prematurity Trial Group. Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med. 2007 Nov 8;357(19):1893-902.

Segal P, Hamilton JK, Sermer M, Connelly PW, Hanley AJ, Zinman B, Retnakaran R. Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy. J Matern Fetal Neonatal Med 2008 Jan;21(1):73-9.

Sermer D, Quercia N, Chong K, Chitayat D. Acrofacial dysostosis syndrome type Rodriguez: prenatal diagnosis and autopsy findings. Am J Med Genet A. 2007 Dec 15;143A(24):3286-9.

Shah PS, Ohlsson A, Perlman M. Hypothermia to treat neonatal hypoxic ischemic encephalopathy. Arch Pediatr Adolesc Med 2007, October, 161:951-8. Am J Med Genet A. 2007 Dec 15;143A(24):3286-9.

Shah V, Taddio A, Hancock R, Shah P, Ohlsson A. Topical amethocaine gel 4% for intramuscular injection in term neonates. Clinical Therapeutics 2008 January, 30(1):166-74.

Shynlova O, Tsui P, Dorogin A, Langille BL, Lye SJ. The expression of transforming growth factor beta in pregnant rat myometrium is hormone and stretch dependent. Reproduction 2007 Sep;134(3):503-11.

Shynlova O, Williams SJ, Draper H, White BG, MacPhee DJ, Lye SJ. Uterine stretch regulates temporal and spatial expression of fibronectin protein and its alpha 5 integrin receptor in myometrium of unilaterally pregnant rats. Biol Reprod 2007 Nov;77(5):880-8. Epub 2007 Aug 22.

Siddiqui M, Goldszmidt E, Fallah S, Kingdom J, Windrim R, Carvalho JC. Complications of exteriorized compared with in situ uterine repair at cesarean delivery under spinal anesthesia: A randomized controlled trial. Obstet Gynecol 2007 Sep;110(3):570-5.

Sierra S, McComb PF. Hysterosalpingography in the investigation of women requesting reversal of sterilization. Should it play a role? J Reprod Med 2008 Jan ;53(1):20-4.

Sloboda DM, Moss TJM, Li S, Matthews SG, Challis JRG, Newnham JP. Expression of glucocorticoid receptor, mineralocorticoid receptor and 11ß-hydroxysteroid dehydrogenase 1 and 2 in the fetal and postnatal ovine hippocampus: Ontogeny and effects of prenatal glucocorticoid exposure. Journal of Endocrinology (2008), May;197(2):213-20.

Sodek KL, Ringuette MJ, Brown TJ. MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells. Br J Cancer 2007 Aug 6;97(3):358-67. Epub 2007 Jul 3. 12 PUBLICATIONS 2007-2008

Soleymanlou N, Jurisicova A, Wu Y, Chijiiwa M, Detmar J, Todros T, Zamudio S, Post M, Caniggia I. Switch in mitochondrial apoptotic rheostat in physiological and pathological models of human placental hypoxia. Am J Pathology 2007 Aug;171(2):496-506.

Somech R, Somers GR, Chitayat D, Grunebaum E, Atkinson A, Kolomietz E, Roifman CM. Fatal lung fibrosis associated with immunodeficiency and gonadal dysgenesis in 46XX sisters--a new syndrome. Am J Med Genet A 2008 Jan; 146(1):8-14.

Spitzer R, Salle P, Wherrett D, Colgan T, Chitayat D, Dodge J, Allen L. Maternal luteoma of pregnancy presenting with virilization in the female infant. J Obstet Gynaecol Can 2007 Oct 29(10):835-40.

Stansfeld SA, Blackmore ER, Zagorski B, Munce SE, Stewart DE, Weller I. Work characteristics and social phobia in a nationally representative employed sample. Can J Psych 2008 June; 53(6):371-6.

Stewart DE. Social determinants of women’s mental health. J Psychosom Res 2007 Sep;63(3):223-4. Epub 2007 Aug 2

Stewart DE, Gagnon A, Saucier JF, Wahoush O, Dougherty G. Postpartum depression symptoms in newcomers. Canadian Journal of Psychiatry February 2008; 53(2):121-124.

Teng L, Robertson Blackmore E, Stewart DE. Healthcare worker’s perceptions of barriers to care by immigrant women with postpartum depression: An exploratory qualitative study. Archives of Women’s Mental Health 2007; 10:93-101.

Thangaroopan M, Wald RM, Silversides CK, Mason J, Smallhorn JF, Sermer M, Colman JM, Siu SC. Incremental diagnostic yield of pediatric cardiac assessment after fetal echocardiography in the offspring of women with congenital heart disease: A prospective study. Pediatrics 2008 Mar;121(3):e660-5. Comment in: Pediatrics 2008 Aug;122(2):472; author reply 472-3.

Thomas B, Eyries M, Montagne K, Martin S, Agrapart M, Simerman-François R, Letarte M, Soubrier F. Altered endothelial gene expression associated with hereditary haemorrhagic telangiectasia. (HHT) Eur J Clin Invest 2007 Jul;37(7):580-8.

Thombs BD. Ziegelstein RC, Stewart DE, Parakh K, Abbey SE, Grace SL. Usefulness of persistent symptoms of depression to predict physical health status 12 months after an acute coronary syndrome. Am J Cardiol 2008 January; 101:15-19.

Titolo D, Mayer CM, Dhillon SS, Cai F, Belsham DD. Estrogen facilitates both phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide Y transcriptional regulation in clonal, immortalized neurons. J Neurosci 2008 Jun 18;28(25):6473-82.

Toal M, Chaddha V, Windrim R, Kingdom J. Ultrasound detection of placental insufficiency in women with elevated second trimester serum alpha-fetoprotein or human chorionic gonadotropin. J Obstet Gynaecol Can 2008 Mar;30(3):198-206.

Toal M, Keating S, Machin G, Dodd J, Adamson SL, Windrim RC, Kingdom JCP. Determinants of adverse perinatal outcome in high-risk women with abnormal uterine artery Doppler. Am J Obstet Gynecol 2008 Mar;198(3):330.e1-7. 13 PUBLICATIONS 2007-2008

Trubiani G, Al Chawaf A, Belsham DD, Barsyte-Lovejoy D, Lovejoy DA.Teneurin carboxy (C)- terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells.Brain Res 2007 Oct 24;1176:27-36. Epub 2007 Aug 22.

Vigod S, Stewart DE. Treatment patterns in Canadian women with urinary incontinence: A need to improve case identification. J Womens Health (Larchmt). 2007 Jun;16(5):707-12

Watts P, Kumar N, Ganesh A, Sastry P, Pilz D, Levin AV, Chitayat D. Chorioretinal dysplasia, hydranencephaly, and intracranial calcifications: Pseudo-TORCH or a new syndrome? Eye 2008 May 22(5):730-3.

Wauman J, De Smet AS, Catteeuw D, Belsham D, Tavernier J. Insulin receptor substrate 4 couples the leptin receptor to multiple signaling pathways Mol Endocrinol 2008 Apr;22(4):965- 77. Epub 2007 Dec 28.

Whitty R, Goldszmidt E, Parkes RK, Carvalho JC. Determination of the ED95 for intrathecal plain bupivacaine combined with fentanyl in active labor. Int J Obstet Anesth 2007 Oct;16(4):341-5. Epub 2007 Aug 13

Williams R, Needles A, Cherin E, Zhou Y-Q, Henkelman RM, Adamson SL, Foster FS. Noninvasive ultrasonic measurement of regional and local pulse-wave velocity in mice. Ultrasound Med Biol 2007 Sep;33(9):1368-75.

Yeboah D, Kalabis GM, Sun M, Ou RC, Matthews SG, Gibb W. Expression and localisation of breast cancer resistance protein (BCRP) in human fetal membranes and decidua and the influence of labour at term. Reprod Fertil Dev 2008;20(2):328-34.

Yee S, Hitkari JA, Greenblatt EM. A follow-up study of women who donated oocytes to known recipient couples for altruistic reasons. Hum Reprod 2007 Jul;22(7):2040-50. Epub 2007 May 15.

Yinon Y, Nevo O, Xu J, Many A, Rolfo A, Todros T, Post M, Caniggia I. Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: Hypoxic regulation via transforming growth factor-beta 3. Am J Pathol 2008 Jan;172(1):77-85. Epub 2007 Dec 21.

Yudin MH, Moravac C, Shah RR. Influence of an “opt-out” test strategy and patient factors on human immunodeficiency virus screening in pregnancy. Obstet Gynecol 2007;110(1):81-6.

Zheng-Fischhöfer Q, Kibschull M, Schnichels M, Kretz M, Petrasch-Parwez E, Strotmann J, Reucher H, Lynn BD, Nagy JI, Lye SJ, Winterhager E, Willecke K. Characterization of connexin31.1-deficient mice reveals impaired placental development. Dev Biol 2007 Dec 1;312(1):258-71. Epub 2007 Sep 26.

14 PUBLICATIONS 2007-2008

Invited Papers, Commentaries, Editorials, Reviews and Book Chapters

Abrams K, Robinson GE. Treating victims of stalking. Directions in Psychiatry 2007;27:25-33.

Allen LM. Management issues in child gynecology. In: Pajpai M, Gearhart JP, Mouriquand PDE, Mitra DK, Radhakrishan J, Mathews R, Etker S, editors. Progress in Pediatric Urology. Volume 10. New Delhi: Penwel Publishers, 2008.pp 84-106.

Allen VM, Armson BA, Wilson RD, Allen VM, Blight C, Gagnon A, Johnson JA, Langlois S, Summers A, Wyatt P, Farine D, Armson BA, Crane J, Delisle MF, Keenan-Lindsay L, Morin V, Schneider CE, Van Aerde J, Society of Obstetricians and Gynaecologists of Canada. Teratogenicity associated with pre- existing and gestational diabetes. Aziz A, Ohlsson A. J Obstet Gynaecol Can 2007 Nov;29(11):927-44.

Bain J. The many faces of testosterone. Clin Interventions in Aging 2007; 2(4):1-10.

Bernardini MQ, Covens A. Imaging of lymph node metastases in cervical cancer.CMAJ 2008 Mar 25;178(7):867-9.

Bullard DG, Caplan H, Derzko C. Sexual problems. In: Feldman MD, Christensen JF, editors, Behavioral Medicine: A Guide for Clinical Practice. 3rd ed., New York: McGraw-Hill ( LANGE Medical Books), October 2007, Chapter 27.

Carvalho JCA. Ultrasound-facilitated epidural and spinal needle placement. Newsletter, American Society of Regional Anesthesia and Pain Management, February 2008.

Carvalho JCA. Ultrasound-guided epidural anesthesia video tutorial, produced for Sonosite Training and Education Program, 2007, available at: http://sonositelearning.com/shop/ultrasound_guided_epidural_ane.php

Carvalho JCA. Uterine fix post C-section should be done in situ. The Medical Post, September 18, 2007. Available at: http://www.medicalpost.com

Chitayat D. Genetic counseling in congenital heart defects. In: Bader R, Hornberger L, Huhta J, editors. The Perinatal Cardiology Handbook. New York: Mosby Inc., 2008.

Chitayat D, Koren G. Fetal malformations associated with drugs and chemicals: Visualization by sonography/fetal MRI. In: Koren G, editor. Medication safety in pregnancy and breastfeeding. New York: McGraw-Hill, Chapter 6.

Colgan TJ, McLachlin CM. Endometrial hyperplasia and carcinoma, extrauterine cancer and unusual tumours. In: Bibbo M, Wilbur D, editors, Comprehensive Cytology, 3rd ed., London: Elsevier, 2007.

Collier CP, Bain J, Clark AF, Godwin M, Hudson RW, Lepage R, Morales A, Moses G, Tremblay R, Vandenberghe H. Functional testosterone: Biochemical assessment of hypogonadism in men - Report from a multidisciplinary workshop hosted by the Ontario Society of Clinical Chemists. The Aging Male 2007 Dec;10(4):211-6.

Connors SL, Levitt P, Matthews SG, Slotkin TA, Johnston MV, Kinney HC, Johnson WG, Dailey RM, Zimmerman AW. Fetal mechanisms in neurodevelopmental disorders. Pediatr Neurol. 2008 Mar;38(3):163-76. Review. 15 PUBLICATIONS 2007-2008

Dajnowiec D, Langille BL. Arterial adaptations to chronic changes in haemodynamic function: coupling vasomotor tone to structural remodelling. Clin Sci (Lond) 2007 Jul;113(1):15-23. Review.

Darragh T, Colgan TJ. ASCCP ’06 consensus guidelines – What’s new and what’s different? College of American Pathologists Today 2007;21:93-8.

Dennis Cl, Fung K, Grigoriadis S, Robinson GE, Romans S, Ross L. Traditional postpartum practices and rituals: A qualitative systematic review. Women’s Health 2007; 3:487-502.

Derzko CM, Bullard DG, Rosenbaum EH, Dollinger M, Rosenbaum IR. Becoming sexually active again. In: Ko AH, Dollinger M, Rosenbaum EH, editors. Everyone’s Guide To Cancer Therapy (US Edition ), 5th ed. Kansas City: Andrews McMeel Publishing LLC, 2007, pp 232-49.

El Shahed AI, Dargaville P, Ohlsson A, Soll RF. Surfactant for meconium aspiration syndrome in full term/near term infants. Cochrane Database Syst Rev 2007 July 18, Issue 3: CD002054.

Esfandiari N. Normal fertilization and implantation. In: Falcone T, Hurd WW, editors, Clinical Reproductive Medicine and Surgery. New York: Mosby/Elsevier, 2007, pp 101-14.

Farine D, Mundle WR, Dodd J, Basso M, Delisle MF, Grabowska K, Hudon L, Menticoglou SM, Murphy-Kaulbeck LC, Ouellet A, Pressey T, Roggensack A, Gagnon R; Maternal Fetal Medicine Committee of the Society of Obstetricians and Gynaecologists of Canada. The use of progesterone for prevention of preterm birth. J Obstet Gynaecol Can 2008 Jan;30(1):67-77.

Farine D, Seaward PG. When it comes to pregnant women sleeping, is left right? J Obstet Gynaecol Can 2007 Oct;29(10):841-2.

Farrell S, Roye C, Crane J, Davis D, Heywood M, Lalonde A, Leyland N, Senikas V, Menard C, Lefebvre G; Society of Obstetricians and Gynecologists of Canada ad hoc Committee on Wait Times. Statement on wait times in obstetrics and gynaecology. J Obstet Gynaecol Can 2008 Mar;30(3):248-70.

Ferguson SE. Management of vulvar cancer. In: Markman M, editor, Atlas of Cancer. 2nd ed. Philadelphia: Current Medicine Group; 2nd edition, 2008.

Gien L, Covens A. Commentary on “Sentinel node dissection is safe in the treatment of early stage vulvar cancer”. International Gynecologic Cancer Society Journal Club. http://www.igcs.org/professionalEducation/journalClub.html, June 2008.

Grigoriadis S, Robinson GE. Gender issues in depression. Ann Clin Psychiatry 2007 Oct-Dec;19(4):247- 55. Review.

Guilbert E, Boroditsky R, Black A, Kives S, Leboeuf M, Mirosh M, Senikas V, Wagner MS, Weir E, York-Lowry J, Reid R, Trussell J; Society of Obstetricians and Gynaecologists of Canada. Canadian Consensus Guideline on Continuous and Extended Hormonal Contraception, 2007. J Obstet Gynaecol Can 2007 Jul;29(7 Suppl 2):S1-32. Haider EA, Toi A, Keating S, Kingdom J, Singer S. Fetal survival following decapitation. Ultrasound Obstet Gynecol 2008 Feb;31(2):223-4.

Hales R, Gabbard G, Phillips K, Oldham J, Stewart DE. Practical strategies for becoming a successful medical book author. Aca Psych 2008; 32(3):183-7. 16 PUBLICATIONS 2007-2008

Halpern SH, Shah B. Disorders of intermediary metabolism. In: Gambling DR, Douglas MJ, McKay RSF, editors. Obstetric anesthesia and uncommon disorders, 2nd ed. Cambridge: Cambridge Press, 2008 pp. 239-49.

Jarvi K, Chitayat D. The genetics you never knew: A genetics primer. Urol Clin North Am 2008 May;35(2):243-56.

Kapoor A, Matthews SG. Antenatal glucocorticoids and programming of neuroendocrine function and behaviour. In: Lagercrantz H, Hanson M. The Newborn Brain – Scientific Basis and Clinical Applications. Cambridge: Cambridge University Press, 2008.

Kayumov L, Lowe A, Rahman SA, Casper RF, Shapiro CM. Prevention of melatonin suppression by nocturnal lighting: relevance to cancer. Eur J Cancer Prev 2007 Aug;16(4):357-62.

Kives S, Lacey J. Normal menstrual physiology. In: Neinstein LS, Gordon CM, Katzman DK, Rosen DS, Woods ER, editors. Adolescent health care: A practical guide, 5th ed., Philadelphia: Lippincott Williams & Wilkins, 2007.

Kupets R, Covens A. Laparoscopic procedures for gynecologic oncology. New York: McGraw Hill, 2007.

Lacy D, Brennard E, Ornstein M, Allen L. Vaginal laceration from a high powered water jet in a premenarcheal female – A case report. Ped Emerg Care 2007: 23(2):112-14.

Lambe EK, Liu RJ, Aghajanian GK. Schizophrenia, hypocretin (orexin), and the thalamocortical activating system. Schizophr Bull 2007 Nov;33(6):1284-90. Epub 2007 Jul 26. Review.

Las Heras F, Pritzker KP, Colgan TJ. Chordoma arising in a mature cystic teratoma of the ovary: a case report. Pathol Res Pract 2007;203(6):467-71. Epub 2007 Apr 6.

Lausman AY, Ellis CA, Beecroft JR, Simons M, Shapiro JL. A rare etiology of delayed postpartum hemorrhage. J Obstet Gynaecol Can 2008 Mar;30(3):239-43.

Lee H, Sodek KL, Hwang Q, Brown TJ, Ringuette M, Sodek J. Phagocytosis of collagen by fibroblasts and invasive cancer cells is mediated by MT1-MMP. Biochem Soc Trans 2007 Aug;35(Pt 4):704-6. Review.

Lefebvre G. Teaching gynecologic surgery and how we learn. Nordic Society of Obstetrics and Gynecology meeting proceedings, Iceland, June 2008.

Lefebvre G. Working together. J Obstet Gynaecol Can 2007 Sep;29(9):699-704. Editorial.

Liston R, Sawchuck D, Young D, Farine D; Society of Obstetricians and Gynaecologists of Canada; British Columbia Perinatal Health Program. Fetal health surveillance: Antepartum and intrapartum consensus guideline. J Obstet Gynaecol Can 2007 Sep;29(9 Suppl 4):S3-56. Erratum in: J Obstet Gynaecol Can. 2007 Nov;29(11):909.

Malviya M, Ohlsson A, Shah S. Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. Cochrane Database Syst Rev 2008 Jan 23;(1):CD003951. 17 PUBLICATIONS 2007-2008

Markman M, Jiménez W, Covens A, Jolly E, Derzko C, Shapiro M. Debate: Patients with recurrent ovarian cancer who experienced a clinical complete remission with initial platinum-based chemotherapy and had a treatment-free interval of at least six months before recurrence should receive platinum-based chemotherapy after any indicated surgery. 2008 Jun; 1(1):22-9.

Matthews SG. Development of the Hypothalamo-Pituitary-Adrenal Axis. In: Textbook of Pediatric Endocrinology. New York: McGraw-Hill (2008).

Maxwell C, Poppas A, Dunn E, Sermer M. Anticoagulation for prosthetic heart valves. In: Rosene- Montella K, Keely EJ, Lee RV, Barbour LA, editors, Medical Care of the Pregnant Patient, 2nd ed., Philadelphia: ACP Press (American College of Physicians), 2008, Chapter 29, pp 344-55.

Maxwell C, Sermer M. Mechanical heart valves and pregnancy. Fet Mat Med Review 2007 Nov; 18(4): 311-31.

McCracken G, Lefebvre G,.Mesh-free anterior vaginal wall repair: History or best practice? The Obstetrician & Gynaecologist 2007;9(4):233-43, also www.rcog.org.uk/togonline.

McDermott CD, Sermer M, Siu SC, David TE, Colman JM. Aortic dissection complicating pregnancy following prophylactic aortic root replacement in a woman with Marfan syndrome. Int J Cardiol 2007 Sep 3;120(3):427-30. Epub 2006 Dec 18.

Money D, Steben M, Yudin M. Society of Obstetricians and Gynaecologists of Canada. Guidelines for the management of herpes simplex virus in pregnancy. J Obstet Gynaecol Can 2008 Jun;30(6):514-26.

Morag I, Ohlsson A. Cycled light in the intensive care unit for preterm/low birth weight infants. (Protocol) Cochrane Database of Systematic Reviews 2008, Jan 23, Issue 1. Art. No.: CD006982. DOI: 10.1002/14651858.CD006982.

Mukhi JS, Percy M. Evaluation of the Journal on Developmental Disabilities. J Dev Disabilities 2008; 14(2):115-9.

Ohlsson A, Walia R, Shah S. Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2008, Jan 23;(1):CD003481.

Percy M, Brown I, Fudge-Schormans A, Martin L. Revisiting the concepts of reliability and validity. J Dev Disabilities 2007;13(3): vii-xx. Editorial.

Percy M, Propst E. Celiac disease: Its many faces and relevance to developmental disabilities. J Dev Disabilities 2008; 14(2): 106-10. Review.

Poppas A, Sermer M. Congenital and acquired heart disease. In: Rosene-Montella K, Keely EJ, Lee RV, Barbour LA, editors, Medical Care of the Pregnant Patient, 2nd ed., Philadelphia: ACP Press (American College of Physicians), 2008, Chapter 26, pp 319-33. Robertson D, Kives S. Adolescent consent in reproductive and sexual health decision-making: Should there be an arbitrary age of consent or should it be based on the 'evolving capacities of the child'? J Pediatr Adolesc Gynecol 2008 Feb; 21(1):47-51.

Robinson AJ, Blaser S, Toi A, Chitayat D, Halliday W, Pantazi S, Gundogan M, Laughlin S, Ryan G. The fetal cerebellar vermis: assessment for abnormal development by ultrasonography and magnetic resonance imaging. Ultrasound Q 2007 Sep; 23(3):211-23. Review. 18 PUBLICATIONS 2007-2008

Ross S, Robert M, Harvey MA, Farrell S, Schulz J, Wilkie D, Lovatsis D, Epp A, Easton W, McMillan B, Schachter J, Gupta C, Weijer C. Ethical issues associated with the introduction of new surgical devices, or just because we can, doesn't mean we should. J Obstet Gynaecol Can 2008 Jun;30(6):508-13.

Shah P, Ohlsson A. Sildenafil for pulmonary hypertension in neonates. Cochrane Database Syst Rev 2007, July 18, Issue 3: CD005494.

Shah V, Ohlsson A. Venepuncture versus heel lance for blood sampling in term neonates. Cochrane Database Syst Rev 2007 Oct 17;(4):CD001452.

Shah V, Ohlsson A, Halliday H, Dunn M. Early administration of inhaled corticosteroids for preventing chronic lung disease in ventilated very low birth weight preterm neonates.Cochrane Database Syst Rev 2007 Oct 17;(4):CD001969.

Shah S, Ohlsson A, Halliday H, Shah V. Inhaled versus systemic corticosteroids for the treatment of chronic lung disease in ventilated very low birth weight preterm infants. Cochrane Database Syst Rev 2007 Oct 17;(4):CD002057.

Shah P, Ohlsson A, Shah J. Continuous negative extrathoracic pressure or continuous positive airway pressure for acute hypoxemic respiratory failure in children. Cochrane Database Syst Rev 2008 Jan 23;(1):CD003699.

Shier RM, Rasty G. Vulvar Seborrheic Keratosis. J Obstet Gynaecol Can 2007 Dec;29(12):967-8.

Shrim A, Garcia-Bournissen F, Maxwell C, Farine D, Koren G. Trastuzumab treatment for breast cancer during pregnancy. Can Fam Physician 2008 Jan;54(1):31-2.

Shrim A, Garcia-Bournissen F, Murphy K, Koren G, Farine D. When pregnant women are not screened for HIV. Can Fam Physician 2007 Oct;53(10):1663-5.

Smith AC, Shuman C, Chitayat D, Steele L, Ray PN, Bourgeois J, Weksberg R. Severe presentation of Beckwith-Wiedemann syndrome associated with high levels of constitutional paternal uniparental disomy for chromosome 11p15. Am J Med Genet A 2007 Dec 15; 143(24):3010-5.

Steinberg WM. Androgen therapy for postmenopausal women. Patient Care Canada 2007 Oct;18(10).

Steinberg WM. Cervical Cancer. Patient Care Canada 2007 Sept;18( 9).

Steinberg WM. Endometrial protection using Esting and Vagifem. Patient Care Canada 2007 Sept;18(9).

Steinberg WM. Hormone therapy for menopausal symptoms. Patient Care Canada 2007 Sept;18(9).

Steinberg WM. HPV vaccination in an older population. The Medical Post May 23, 2008.

Steinberg WM. Parovirus in pregnancy. The Medical Post, June 3, 2008.

Steinberg WM. Routine ovarian ultrasounds. Patient Care Canada 2007 Nov;18(11).

Stewart DE. Battling depression. CMAJ 2008 Apr;178(8):1023.

19 PUBLICATIONS 2007-2008

Stewart DE. Psychosocial aspects of over the counter emergency contraception. Health Canada, June 2008.

Stewart DE, Gagliardi A, Johnston M, Howlett R, Barata P, Lewis N, Oliver T, Mai V; HPV Self- collection Guidelines Panel. Self-collected samples for testing of oncogenic human papillomavirus: A systematic review. J Obstet Gynaecol Can 2007 Oct;29(10):817-28.

Stewart DE, Malleson AG. Medicos viajeros Bolivianos. CMAJ 2008 Feb; 178(5): 602.

Stewart DE, Vigod, SN. Psychiatric management of victims of physical and sexual abuse and rape. In: Psychiatry, 3rd edition. Tasman A, Maj M, First MB, Kay J, Lieberman JA, editors, London: John Wiley & Sons, May 2008, pp.2576-92.

Ternamian A. Port creation during laparoscopic hysterectomy. In: Mettler L, editor. Manual of New Hysterectomy Techniques. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd., 2007.

Toporsian M, Letarte M. HHT: A model to probe the biology of the vascular endothelium. In: Aird WC, editor, The Endothelium A Comparative Reference. Endothelial Biomedicine. Cambridge: Cambridge University Press, 2007.

Trinkaus M, Chin S, Wolfman, W, Simmons C, Clemons M. Should urogenital atrophy in breast cancer survivors be treated with topical estrogens? Oncologist 2008 Mar;13(3):222-31. Review.

Wilson RD, Johnson J, Summers A, Wyatt P, Allen V, Gagnon A, Langlois S, Blight C, Money DM, Boucher M, Gruslin A, MacKinnon CJ, Paquet C, van Schalkwyk J, Cohen HR, Steben M, Wong T, Yudin MH. Principles of human teratology: Drug, chemical, and infectious exposure, SOGC Clinical Practice Guideline. J Obstet Gynaecol Can. 2007 Nov;29(11):911-26.

Windrim R. Ontario Maternity Care Expert Panel (OMCEP) Report. Women’s Health Council / Ontario Ministry of Health, August 2007.

Yinon Y, Kelly EN, Ryan G. Fetal pleural effusions. Best Pract Res Clin Obstet Gynaecol 2008 Feb;22(1):77-96.

Yudin MH, Embree J, Senikas V, Brown V. HPV vaccination: A new standard of care. Advancing In Continuing Medical Education Online. www.advancingin.com, 2007.

20 PUBLICATIONS 2008-2009 PEER-REVIEWED PUBLICATIONS 2008-2009 Original Research

Aggarwal A, Thomas M, Spitzer R, Stephens D, Kives S, Allen L: Methotrexate in the management of adolescents with ectopic pregnancy – A physician survey. J Obstet Gynaecol Can 2009;31(3):254-262.

Ahmed A, Stewart DE, Teng L, Wahoush O, Gagnon AJ. Experiences of immigrant new mothers with symptoms of depression. Arch Womens Ment Health 2008 Sep;11(4):295-303. Epub 2008 Aug 2.

Akbari MR, Ghadirian P, Robidoux A, Foumani M, Sun Y, Royer R, Zandvakili I, Lynch H, Narod SA. Germline RAP80 mutations and susceptibility to breast cancer. Breast Cancer Res Treat. 2009 Jan;113(2):377-81. Epub 2008 Feb 28.

Alazzam M, Tidy J, Hancock BW, Osborne R. First line chemotherapy in low risk gestational trophoblastic neoplasia. Cochrane Database Syst Rev 2009 Jan 21;(1):CD007102.

Al-Saleh S, Mei-Zahav M, Faughnan ME, Maclusky IB, Carpenter S, Letarte M, Ratjen F. Screening for pulmonary and cerebral arteriovenous malformations in children with Hereditary Hemorrhagic Telangiectasia. 2009 Oct;34(4):875-81. Epub 2009 Apr 22.

Aximu D, Azad A, Ni R, Colgan T, Nanji S. A pilot evaluation of a novel immunohistochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression (ProEx C) in cervical adenocarcinoma in situ, adenocarcinoma, and benign glandular mimics. Int J Gynecol Pathol 2009 Mar;28(2):114-9.

Baczyk D, Drewlo S, Proctor L, Dunk C, Lye S, Kingdom J. Glial cell missing-1 transcription factor is required for the differentiation of the human trophoblast. Cell Death Differ 2009 May;16(5):719-27. Epub 2009 Feb 13.

Balakier H, Mandel R, Sojecki A, Motamedi G, Zaver S, Librach C. Laser zona thinning in women aged

Balki M, Lee Y, Halpern S, Carvalho JC. Ultrasound imaging of the lumbar spine in the transverse plane: The correlation between estimated and actual depth to the epidural space in obese parturients. Anesth Analg 2009 Jun;108(6):1876-81.

Barata PC, Mai V, Howlett R, Gagliardi AR, Stewart DE. Discussions about self-obtained samples for HPV testing as an alternative for cervical cancer prevention. J Psychosom Obstet Gynaecol 2008 Dec;29(4):251-7.

Bassler D, Stoll BJ, Schmidt B, Asztalos EV, Roberts RS, Robertson CM, Sauve RS; Trial of Indomethacin Prophylaxis in Preterms Investigators (Arne Ohlsson). Using a count of neonatal morbidities to predict poor outcome in extremely low birth weight infants: Added role of neonatal infection. Pediatrics 2009 Jan;123(1):313-8. 21 PUBLICATIONS 2008-2009

Bates HE, Sirek A, Kiraly MA, Yue JT, Riddell MC, Matthews SG, Vranic M. Adaptation to intermittent stress promotes maintenance of beta-cell compensation: comparison with food restriction. Am J Physiol Endocrinol Metab 2008 Oct;295(4):E947-58. Epub 2008 Aug 19.

Bayani J, Paderova J, Murphy J, Rosen B, Zielenska M, Squire JA. Distinct patterns of structural and numerical chromosomal instability characterize sporadic ovarian cancer. Neoplasia 2008 Oct;10(10):1057-65.

Bedaiwy MA, Mousa NA, Casper RF. Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists. Fertil Steril 2009 Apr;91(4 Suppl):1574-7. Epub 2008 Oct 29.

Bedaiwy MA, Shokry M, Mousa N, Claessens A, Esfandiari N, Gotleib L, Casper R. Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination. Fertil Steril 2009 Jun;91(6):2501-7. Epub 2008 May 23.

Beiner ME, Hauspy J, Rosen B, Murphy J, Laframboise S, Nofech-Mozes S, Ismiil N, Rasty G, Khalifa MA, Covens A. Radical vaginal trachelectomy vs. radical hysterectomy for small early stage cervical cancer: A matched case-control study. Gynecol Oncol 2008 Aug;110(2):168-71. Epub 2008 Jun 9.

Beiner ME, Zhang WW, Zhang S, Gallinger S, Sun P, Narod SA. Mutations of the MYH gene do not substantially contribute to the risk of breast cancer. Breast Cancer Res Treat 2009 Apr;114(3):575-8. Epub 2008 May 4.

Bentov Y, Brown TJ, Akbari MR, Royer R, Risch H, Rosen B, McLaughlin J, Sun P, Zhang S, Narod SA, Casper RF. Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer. PLoS One 2009 Jun 15;4(6):e5918.

Berchuck A, Iversen ES, Luo J, Clarke JP, Horne H, Levine DA, Boyd J, Alonso MA, Secord AA, Bernardini MQ, Barnett JC, Boren T, Murphy SK, Dressman HK, Marks JR, Lancaster JM. Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome. Clin Cancer Res 2009 Apr 1;15(7):2448-55. Epub 2009 Mar 24.

Bisazza A, Giustetto P, Rolfo A, Caniggia I, Balbis S, Guiot C, Cavalli R. Microbubble- mediated oxygen delivery to hypoxic tissues as a new therapeutic device. Conf Proc IEEE Eng Med Biol Soc 2008;2008:2067-70.

Blumenfeld Z, Abdallah W, Kaplan D, Nevo O. Endometrial thickness – A practical prospective marker for the risk of surgical intervention after RU486 induced abortion. Clinical Medicine: Reproductive Health Nov 2008;2:25-30.

Burton GJ, Woods AW, Jauniaux E, Kingdom JC. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta 2009 Jun;30(6):473-82. Epub 2009 Apr 17.

Byrski T, Huzarski T, Dent R, Gronwald J, Zuziak D, Cybulski C, Kladny J, Gorski B, Lubinski J, Narod SA. Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat 2009 May;115(2):359-63. Epub 2008 Jul 23. 22 PUBLICATIONS 2008-2009

Casciani V, Premyslova M, Luo D, Marinoni E, Moscarini M, Di Iorio R, Challis JR. Effect of calcium ionophore A23187 on prostaglandin synthase type 2 and 15-hydroxy-prostaglandin dehydrogenase expression in human chorion trophoblast cells. Am J Obstet Gynecol 2008 Nov;199(5):554.e1-8. Epub 2008 Jul 17.

Cavanagh PC, Dunk C, Pampillo M, Szereszewski JM, Taylor JE, Kahiri C, Han V, Lye S, Bhattacharya M, Babwah AV. Gonadotropin-releasing hormone-regulated chemokine expression in human placentation. Am J Physiol Cell Physiol 2009 Jul;297(1):C17-27. Epub 2009 Apr 15.

Challis JR, Connor K. Glucocorticoids, 11beta-hydroxysteroid dehydrogenase: Mother, fetus, or both? Endocrinology 2009 Mar;150(3):1073-4.

Chang PT, Vilos GA, Abu-Rafea B, Hollett-Caines J, Abyaneh ZN, Edris F. Comparison of clinical outcomes with low-voltage (cut) versus high-voltage (coag) waveforms during hysteroscopic endometrial ablation with the rollerball: A pilot study. J Minim Invasive Gynecol 2009 May-Jun;16(3):350-3.

Chin SN, Pinto V, Rosen B, Oza A, Dodge J, Murphy J, Mackay H. Evaluation of an intraperitoneal chemotherapy program implemented at the Princess Margaret Hospital for patients with epithelial ovarian carcinoma. Gynecol Oncol 2009 Mar;112(3):450-4. Epub 2009 Jan 10.

Chitayat D, Keating S, Zand DJ, Costa T, Zackai EH, Silverman E, Tiller G, Unger S, Miller S, Kingdom J, Toi A, Curry CJ. Chondrodysplasia punctata associated with maternal autoimmune diseases: Expanding the spectrum from systemic lupus erythematosus (SLE) to mixed connective tissue disease (MCTD) and scleroderma report of eight cases. Am J Med Genet A. 2008 Dec 1;146A(23):3038-53.

Chong K, Keating S, Hurst S, Summers A, Berger H, Seaward G, Martin N, Friedberg T, Chitayat D. Cornelia de Lange syndrome (CdLS): prenatal and autopsy findings. Prenat Diagn 2009 May;29(5):489-94.

Chopra KK, Ravindran A, Kennedy SH, Mackenzie B, Matthews S, Anisman H, Bagby RM, Farvolden P, Levitan RD. Sex differences in hormonal responses to a social stressor in chronic major depression. Psychoneuroendocrinology. 2009 Sep;34(8):1235-41. Epub 2009 Apr 22

Chua SJ, Bielecki R, Wong CJ, Yamanaka N, Rogers IM, Casper RF. Neural progenitors, neurons and oligodendrocytes from human umbilical cord blood cells in a serum-free, feeder-free cell culture. Biochem Biophys Res Commun 2009 Feb 6;379(2):217-21. Epub 2008 Dec 25.

Connor KL, Bloomfield FH, Oliver MH, Harding JE, Challis JR. Effect of periconceptional undernutrition in sheep on late gestation expression of mRNA and protein from genes involved in fetal adrenal steroidogenesis and placental prostaglandin production. Reprod Sci 2009 Jun;16(6):573-83. Epub 2009 Mar 16.

Coolen J, Wells T, Young C, Singh SS, Liu K. Society of Obstetricians and Gynaecologists of Canada Junior Member Committee Survey: Future career plans of Canadian Obstetrics and Gynaecology Residents. J Obstet Gynaecol Can 2008 Dec;30(12):1140-5.

Costa SL, Proctor L, Dodd JM, Toal M, Okun N, Johnson JA, Windrim R, Kingdom JC. Screening for placental insufficiency in high-risk pregnancies: Is earlier better? Placenta 2008 Dec;29(12):1034-40. Epub 2008 Oct 19. 23 PUBLICATIONS 2008-2009

Cox B, Kotlyar M, Evangelou AI, Ignatchenko V, Ignatchenko A, Whiteley K, Jurisica I, Adamson SL, Rossant J, Kislinger T. Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology. Mol Syst Biol 2009 5:279.

Cullinane AR, Straatman-Iwanowska A, Seo JK, Ko JS, Song KS, Gizewska M, Gruszfeld D, Gliwicz D, Tuysuz B, Erdemir G, Sougrat R, Wakabayashi Y, Hinds R, Barnicoat A, Mandel H, Chitayat D, Fischler B, Garcia-Cazorla A, Knisely AS, Kelly DA, Maher ER, Gissen P. Molecular investigations to improve diagnostic accuracy in patients with ARC syndrome. Hum Mutat. 2009 Feb;30(2):E330-7.

Cybulski C, Górski B, Huzarski T, Byrski T, Gronwald J, Debniak T, Wokolorczyk D, Jakubowska A, Serrano-Fernández P, Dork T, Narod SA, Lubinski J. Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations. J Med Genet 2009 Feb;46(2):132-5. Epub 2008 Oct 17.

Cybulski C, Huzarski T, Byrski T, Gronwald J, Debniak T, Jakubowska A, Górski B, Wokołorczyk D, Masojć B, Narod SA, Lubiński J. Estrogen receptor status in CHEK2-positive breast cancers: Implications for chemoprevention. Clin Genet 2009 Jan;75(1):72-8. Epub 2008 Nov 17.

Cybulski C, Wokołorczyk D, Gliniewicz B, Sikorski A, Górski B, Jakubowska A, Huzarski T, Byrski T, Debniak T, Gronwald J, Lubiński J, Narod SA. A six-nucleotide deletion in the CASP8 promoter is not associated with a susceptibility to breast and prostate cancers in the Polish population. Breast Cancer Res Treat. 2008 Nov;112(2):367-8. Epub 2007 Dec 21.

Dent R, Hanna WM, Trudeau M, Rawlinson E, Sun P, Narod SA. Pattern of metastatic spread in triple-negative breast cancer. Breast Cancer Res Treat 2009 May;115(2):423-8. Epub 2008 Jun 10.

DeSouza LV, Romaschin AD, Colgan TJ, Siu KW. Absolute quantification of potential cancer markers in clinical tissue homogenates using multiple reaction monitoring on a hybrid triple quadrupole/linear ion trap tandem mass spectrometer. Anal Chem 2009 May 1;81(9):3462-70.

DeSouza LV, Taylor AM, Li W, Minkoff MS, Romaschin AD, Colgan TJ, Siu KW. Multiple reaction monitoring of mTRAQ-labeled peptides enables absolute quantification of endogenous levels of a potential cancer marker in cancerous and normal endometrial tissues. J Proteome Res 2008 Aug;7(8):3525-34. Epub 2008 Jul 17.

Draper H, Chitayat D, Ein SH, Langer JC. Long-term functional results following resection of neonatal sacrococcygeal teratoma. Pediatr Surg Int 2009 Mar;25(3):243-6. Epub 2009 Feb 3.

Drewlo S, Baczyk D, Dunk C, Kingdom J. Fusion assays and models for the trophoblast. Methods Mol Biol 2008;475:363-82.

Eisen A, Lubinski J, Gronwald J, Moller P, Lynch HT, Klijn J, Kim-Sing C, Neuhausen SL, Gilbert L, Ghadirian P, Manoukian S, Rennert G, Friedman E, Isaacs C, Rosen E, Rosen B, Daly 24 PUBLICATIONS 2008-2009

M, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group. Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers. J Natl Cancer Inst 2008 Oct 1;100(19):1361-7. Epub 2008 Sep 23.

Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL. Alternative induced pluripotent stem cell characterization criteria for in vitro applications. Cell Stem Cell 2009 Mar 6;4(3):198-9; author reply 202.

Emack J, Kostaki A, Walker CD, Matthews SG. Chronic maternal stress affects growth, behaviour and hypothalamo-pituitary-adrenal function in juvenile offspring. Horm Behav 2008 Sep;54(4):514-20. Epub 2008 Mar 20.

Endrikat J, Shapiro H, Lukkari-Lax E, Kunz M, Schmidt W, Fortier M. A Canadian, multicentre study comparing the efficacy of a levonorgestrel-releasing intrauterine system to an oral contraceptive in women with idiopathic menorrhagia. J Obstet Gynaecol Can Apr 2009; 31(4):340-7.

Ertmański S, Metcalfe K, Trempała J, Głowacka MD, Lubiński J, Narod SA, Gronwald J. Identification of patients at high risk of psychological distress after BRCA1 genetic testing. Genet Test Mol Biomarkers 2009 Jun;13(3):325-30.

Esfandiari N, Burjaq H, Gotlieb L, Casper RF. Seminal hyperviscosity is associated with poor outcome of in vitro fertilization and embryo transfer: a prospective study. Fertil Steril 2008 Nov;90(5):1739-43. Epub 2008 Feb 4.

Esfandiari N, Claessens EA, Burjaq H, Gotlieb L, Casper RF. Ongoing twin pregnancy after rescue intracytoplasmic sperm injection of unfertilized abnormal oocytes. Fertil Steril 2008 Jul;90(1):199.e5-7. Epub 2008 Mar 7.

Esfandiari N, Claessens EA, Gotlieb L, Casper RF. Don't judge a book by its cover; A quintuplet pregnancy following transfer of five poor-quality embryos. Fertil Steril 2008 Nov;90(5):2007.e13-5. Epub 2008 Apr 18.

Esfandiari N, Coogan-Prewer J, Gotlieb L, Claessens EA, Casper RF. Successful pregnancy following double-frozen embryo transfer in a patient with repeated implantation failure. Fertil Steril 2008 Oct;90(4):1199.e13-5. Epub 2008 Feb 20.

Esfandiari N, Nazemian Z, Casper RF. Three-dimensional culture of endometrial cells: An in vitro model of endometriosis. Am J Reprod Immunol 2008 Oct;60(4):283-9. Epub 2008 Aug 1.

Fergusson D, Hutton B, Hogan DL, LeBel L, Blajchman MA, Ford JC, Hebert P, Kakadekar A, Kovacs L, Lee S, Sankaran K, Shapiro S, Smyth JA, Ramesh K, Bouali NR, Tinmouth A, Walker R. The age of red blood cells in premature infants (ARIPI) randomized controlled trial: Study design. Transfus Med Rev 2009 Jan;23(1):55-61.

Finch A, Metcalfe K, Lui J, Springate C, Demsky R, Armel S, Rosen B, Murphy J, Elit L, Sun P, Narod S. Breast and ovarian cancer risk perception after prophylactic salpingo-oophorectomy due to an inherited mutation in the BRCA1 or BRCA2 gene. Clin Genet 2009 Mar;75(3):220-4. 25 PUBLICATIONS 2008-2009

Flanagan JM, Munoz-Alegre M, Henderson S, Tang T, Sun P, Johnson N, Fletcher O, Dos Santos Silva I, Peto J, Boshoff C, Narod S, Petronis A. Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. Hum Mol Genet 2009 Apr 1;18(7):1332-42. Epub 2009 Jan 19.

Gajecka M, Gentles AJ, Tsai A, Chitayat D, Mackay KL, Glotzbach CD, Lieber MR, Shaffer LG. Unexpected complexity at breakpoint junctions in phenotypically normal individuals and mechanisms involved in generating balanced translocations t(1;22)(p36;q13). Genome Res 2008 Nov;18(11):1733-42. Epub 2008 Sep 2.

Gajecka M, Saadeh R, Mackay KL, Glotzbach CD, Spodar K, Chitayat D, Shaffer LG. Clinical and molecular cytogenetic characterization of four patients with unbalanced translocation der(1)t(1;22)(p36;q13).Am J Med Genet A 2008 Nov 1;146A(21):2777-84.

Genetics Committee of the Society of Obstetricians and Gynaecologists of Canada(SOGC); Prenatal Diagnosis Committee of the Canadian College of Medical Geneticists(CCMG), Chitayat D, Wyatt PR, Wilson RD, Johnson JA, Audibert F, Allen V, Gagnon A, Langlois S, Blight C, Brock JA, Désilets V, Farell SA, Geraghty M, Nelson T, Nikkel SM, Skidmore D, Shugar A. Fragile X testing in obstetrics and gynaecology in Canada. J Obstet Gynaecol Can 2008 Sep;30(9):837-46.

Ghorab Z, Ismiil N, Covens A, Nofech-Mozes S, Saad RS, Dubé V, Khalifa MA. Postradical vaginal trachelectomy follow-up by isthmic-vaginal smear cytology: A 13-year audit. Diagn Cytopathol 2009 Sep;37(9):641-6.

Gien LT, Covens A. Lymph node assessment in cervical cancer: prognostic and therapeutic implications. J Surg Oncol 2009 Mar 15;99(4):242-7.

Ginsburg O, Ghadirian P, Lubinski J, Cybulski C, Lynch H, Neuhausen S, Kim-Sing C, Robson M, Domchek S, Isaacs C, Klijn J, Armel S, Foulkes WD, Tung N, Moller P, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group (Rosen B). Smoking and the risk of breast cancer in BRCA1 and BRCA2 carriers: an update. Breast Cancer Res Treat 2009 Mar;114(1):127-35. Epub 2008 May 16.

Glanc P, Salem S, Farine D. Adnexal masses in the pregnant patient: A diagnostic and management challenge. Ultrasound Q 2008; 24(4):225-40.

Gray SP, Kenna K, Bertram JF, Hoy WE, Yan EB, Bocking AD, Brien JF, Walker DW, Harding R, Moritz KM. Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep Am J Physiol Regul Integr Comp Physiol 2008 Aug;295(2):R568-74. Epub 2008 Jun 18.

Gronwald J, Cybulski C, Piesiak W, Suchy J, Huzarski T, Byrski T, Gorski B, Debniak T, Szwiec M, Wokolowczyk D, Matuszewski M, Sun P, Lubinski J, Narod SA. Cancer risks in first-degree relatives of CHEK2 mutation carriers: Effects of mutation type and cancer site in proband. Br J Cancer 2009 May 5;100(9):1508-12.

Gronwald J, Pijpe A, Byrski T, Huzarski T, Stawicka M, Cybulski C, van Leeuwen F, Lubiński J, Narod SA. Early radiation exposures and BRCA1-associated breast cancer in young women from Poland. Breast Cancer Res Treat 2008 Dec;112(3):581-4. Epub 2008 Jan 18. 26 PUBLICATIONS 2008-2009

Gucciardi E, DeMelo M, Booth G, Tomlinson G, Stewart DE. Individual and contextual factors associated with follow-up use of diabetes self-management education programmes: A multisite prospective analysis. Diabet Med 2009 May;26(5):510-7.

Guo L, Choufani S, Ferreira J, Smith A, Chitayat D, Shuman C, Uxa R, Keating S, Kingdom J, Weksberg R. Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae. Dev Biol 2008 Aug 1;320(1):79-91. Epub 2008 Apr 27.

Halpern SH, Soliman A, Yee J, Angle P, Ioscovich A. Conversion of epidural labour analgesia to anaesthesia for Caesarean section: A prospective study of the incidence and determinants of failure. Br J Anaesth. 2009 Feb;102(2):240-3. Epub 2008 Dec 9.

Han A, Rotermann M, Fuller-Thomaon, Ray JG. Pre-conceptional folic acid supplement use according to maternal country of birth. JObstet Gynaecol Can 2009 Mar;31(3):222-6.

Heslehurst N, Simpson H, Ells LJ, Rankin J, Wilkinson J, Lang R, Brown TJ, Summerbell CD. The impact of maternal BMI status on pregnancy outcomes with immediate short-term obstetric resource implications: A meta-analysis. Obes Rev 2008 Nov;9(6):635-83. Epub 2008 Jul 29.

Hui AB, Shi W, Boutros PC, Miller N, Pintilie M, Fyles A, McCready D, Wong D, Gerster K, Waldron L, Jurisica I, Penn LZ, Liu FF. Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest 2009 May;89(5):597-606. Epub 2009 Mar 16. Erratum in: Lab Invest. 2009 Jun;89(6):726. Waldron, Levi [added].

Imperatore A, Li W, Petraglia F, Challis JR. Urocortin 2 stimulates estradiol secretion from cultured human placental cells: an effect mediated by the type 2 corticotrophin-releasing hormone (CRH) receptor. Reprod Sci 2009 Jun;16(6):551-8. Epub 2009 May 5.

Inouye KE, Chan O, Yue JT, Andrews M, Li Q, Matthews SG, Vranic M. The effect of long- term insulin treatment with and without antecedent hypoglycemia on neuropeptide and corticosteroid receptor expression in the brains of diabetic rats. Brain Res Bull 2008 Oct 22;77(4):149-57. Epub 2008 Jul 29.

Ismiil N, Ghorab Z, Covens A, Nofech-Mozes S, Saad R, Dubé V, Khalifa MA. Intraoperative margin assessment of the radical trachelectomy specimen. Gynecol Oncol 2009 Apr;113(1):42-6. Epub 2009 Jan 26.

Ismiil N, Ghorab Z, Nofech-Mozes S, Plotkin A, Covens A, Osborne R, Kupets R, Khalifa MA. Intraoperative consultation in gynecologic pathology: A 6-year audit at a tertiary care medical center. Int J Gynecol Cancer 2009 Jan;19(1):152-7.

Jakubowska A, Jaworska K, Cybulski C, Janicka A, Szymańska-Pasternak J, Lener M, Narod SA, Lubiński J; IHCC-Breast Cancer Study Group. Do BRCA1 modifiers also affect the risk of breast cancer in non-carriers? Eur J Cancer 2009 Mar;45(5):837-42. Epub 2008 Dec 13.

Jaworowska E, Serrano-Fernández P, Tarnowska C, Lubiński J, Brzosko M, Flicinski J, Masojc B, Matyjasik J, Scott RJ, Narod SA, Lubiński J. Familial association of laryngeal, lung, stomach and early-onset breast cancer. Breast Cancer Res Treat 2008 Nov;112(2):359-61. Epub 2007 Dec 21. 27 PUBLICATIONS 2008-2009

Johnson N, Sermer M, Lausman A, Maxwell C. Obstetric outcomes of women with intracranial neoplasms. Int J Gynaecol Obstet Int J Gynaecol Obstet 2009 Apr;105(1):56-9. Epub 2009 Jan 19.

Johnson N, Windrim R, Chong K, Viero S, Thompson M, Blaser S. Prenatal diagnosis of solitary median maxillary central incisor syndrome by magnetic resonance imaging. Ultrasound Obstet Gynecol 2008 Jul;32(1):120-2.

Joseph KS, Fahey J, Platt RW, Liston RM, Lee SK, Sauve R, Liu S, Allen AC, Kramer MS. An outcome-based approach for the creation of fetal growth standards: do singletons and twins need separate standards? Am J Epidemiol 2009 Mar 1;169(5):616-24. Epub 2009 Jan 6.

Jurisicova A, Jurisica I, Kislinger T. Advances in ovarian cancer proteomics: The quest for biomarkers and improved therapeutic interventions. Expert Rev Proteomics 2008 Aug;5(4):551- 60.

Kapoor A, Kostaki A, Janus C, Matthews SG. The effects of prenatal stress on learning in adult offspring is dependent on the timing of the stressor. Behav Brain Res 2009 Jan 30;197(1):144-9. Epub 2008 Aug 22.

Kapoor A, Leen J, Matthews SG. Molecular regulation of the hypothalamic-pituitary-adrenal axis in adult male guinea pigs after prenatal stress at different stages of gestation. J Physiol 2008 Sep 1;586(Pt 17):4317-26. Epub 2008 Jul 17.

Kapoor A, Matthews SG. Prenatal stress modifies behavior and hypothalamic-pituitary-adrenal function in female guinea pig offspring: Effects of timing of prenatal stress and stage of reproductive cycle. Endocrinology 2008 Dec;149(12):6406-15. Epub 2008 Aug 28.

Kassam SM, Herman PM, Goodfellow NM, Alves NC, Lambe EK. Developmental excitation of corticothalamic neurons by nicotinic acetylcholine receptors. J Neurosci 2008 Aug 27;28(35):8756-64.

Kayemba-Kay's S, Geary MP, Pringle J, Rodeck CH, Kingdom JC, Hindmarsh PC. Gender, smoking during pregnancy and gestational age influence cord leptin concentrations in newborn infants. Eur J Endocrinol 2008 Sep;159(3):217-24. Epub 2008 Jun 4.

Khazaei M, Montaseri A, Casper RF. Letrozole stimulates the growth of human endometrial explants cultured in three-dimensional fibrin matrix. Fertil Steril 2009 May;91(5 Suppl):2172-6. Epub 2008 Apr 9.

Kiehn L, Murphy KE, Yudin MH, Loeb M. Self-reported protective behaviour against West Nile Virus among pregnant women in Toronto. J Obstet Gynaecol Can 2008 Dec;30(12):1103-9.

Kollara A, Brown TJ. Modulation of aryl hydrocarbon receptor activity by four and a half LIM domain 2. Int J Biochem Cell Biol 2009 May;41(5):1182-8. Epub 2008 Oct 28.

Kotsopoulos J, Librach CL, Lubinski J, Gronwald J, Kim-Sing C, Ghadirian P, Lynch HT, Moller P, Foulkes WD, Randall S, Manoukian S, Pasini B, Tung N, Ainsworth PJ, Cummings S, Sun P, Narod SA; Hereditary Breast Cancer Clinical Study Group. Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: a case-control study. Cancer Causes Control. 2008 Dec;19(10):1111-9. Epub 2008 May 29. 28 PUBLICATIONS 2008-2009

Kotsopoulos J, Zhang WW, Zhang S, McCready D, Trudeau M, Zhang P, Sun P, Narod SA. Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer. Breast Cancer Res Treat 2008 Dec;112(3):585-93. Epub 2008 Jan 19.

Kotsopoulos J, Shen H, Rao AV, Poll A, Ainsworth P, Fleshner N, Narod SA. A BRCA1 mutation is not associated with increased indicators of oxidative stress. Clin Breast Cancer 2008 Dec;8(6):506-10.

Kovacs AH, Harrison JL, Colman JM, Sermer M, Siu SC, Silversides CK. Pregnancy and contraception in congenital heart disease: What women are not told. J Am Coll Cardiol 2008 Aug 12;52(7):577-8.

Lacbawan F, Solomon BD, Roessler E, El-Jaick K, Domené S, Vélez JI, Zhou N, Hadley D, Balog JZ, Long R, Fryer A, Smith W, Omar S, McLean SD, Clarkson K, Lichty A, Clegg NJ, Delgado MR, Levey E, Stashinko E, Potocki L, Vanallen MI, Clayton-Smith J, Donnai D, Bianchi DW, Juliusson PB, Njølstad PR, Brunner HG, Carey JC, Hehr U, Müsebeck J, Wieacker PF, Postra A, Hennekam RC, van den Boogaard MJ, van Haeringen A, Paulussen A, Herbergs J, Schrander-Stumpel CT, Janecke AR, Chitayat D, Hahn J, McDonald-McGinn DM, Zackai EH, Dobyns WB, Muenke M. Clinical spectrum of SIX3-associated mutations in holoprosencephaly: correlation between genotype, phenotype and function. J Med Genet 2009 Jun;46(6):389-98. Epub 2009 Apr 2.

Langlois S, Ford JC, Chitayat D, Désilets VA, Farrell SA, Geraghty M, Nelson T, Nikkel SM, Shugar A, Skidmore D, Allen VM, Audibert F, Blight C, Gagnon A, Johnson JA, Wilson RD, Wyatt P. Carrier screening for thalassemia and hemoglobinopathies in Canada. J Obstet Gynaecol Can 2008 Oct;30(10):950-9.

Laskin CA, Spitzer KA, Clark CA, Crowther MR, Ginsberg JS, Hawker GA, Kingdom JC, Barrett J, Gent M. Low molecular weight heparin and aspirin for recurrent pregnancy loss: Results from the randomized, controlled HepASA Trial. J Rheumatol 2009 Feb;36(2):279-87.

Lausman A, Al-Yaseen E, Sam D, Nitsch R, Barrett JFR, Chan W-S. Intrahepatic Cholestasis of pregnancy in women with a multiple pregnancy: An analysis of risks and pregnancy outcomes. JOGC Nov 2008;30(11):1008-13.

Lausman AY, Kingdom JC, Bradley TJ, Slorach C, Ray JG. Subclinical atherosclerosis in association with elevated placental vascular resistance in early pregnancy. Atherosclerosis 2009 Sep;206(1):33-5. Epub 2009 Feb 20.

Lilker S, Rofaeel A, Balki M, Carvalho JC. Comparison of fentanyl and sufentanil as adjuncts to bupivacaine for labor epidural analgesia. J Clin Anesth. 2009 Mar;21(2):108-12.

Lim K, Kelly V, Stewart J, Xie J, Cho YB, Moseley J, Brock K, Fyles A, Lundin A, Rehbinder H, Milosevic M. Pelvic radiotherapy for cancer of the cervix: Is what you plan actually what you deliver? Int J Radiat Oncol Biol Phys 2009 May 1;74(1):304-12.

Liu KE, Greenblatt EM. Elevated day 3 follicle stimulating hormone/luteinizing hormone ratio > 2 is associated with higher rates of cancellation in in vitro fertilization-embryo transfer cycles. Fertil Steril 2008 Aug;90(2):297-301. 29 PUBLICATIONS 2008-2009

Luria O, Jaffa A, Farine D, Hassan S, Lysikiewicz A, Kees S, Barnea O. Effects of the individual uterine contraction on fetal head descent and cervical dilatation during the active stage of labor. Eur J Obstet Gynecol Reprod Biol 2009 May;144 Suppl 1:S101-7. Epub 2009 Mar 10.

Magalhaes J, Carvalho J, Parkes R, Kingdom J, Li Y, Balki M. Oxytocin pretreatment decreases oxytocin-induced myometrial contractions in pregnant rats in a concentration- dependent but not time-dependent manner. Reprod Sci 2009 May;16(5):501-8. Epub 2009 Jan 22.

Malowany JI, Rieckenberg RM, Okafo BA, Colgan TJ. Glomus tumor presenting as a periurethral mass. J Low Genit Tract Dis 2008 Oct;12(4):316-9. Erratum in: J Low Genit Tract Dis 2009 Jan;13(1):61.

Malvasi A, Tinelli A, Farine D, Rahimi S, Cavallotti C, Vergara D, Martignago R, Stark M. Effects of visceral peritoneal closure on scar formation at cesarean delivery. Int J Gynaecol Obstet Int J Gynaecol Obstet. 2009 May;105(2):131-5. Epub 2009 Feb 20.

Malvasi A, Tinelli A, Tinelli R, Cavallotti C, Farine D. The diagnosis and management of post- cesarean section hemorrhagic shock. J Matern Fetal Neonatal Med 2008 Jul;21(7):487-91.

Martin AM, Berger H, Nisenbaum R, Lausman AY, Macgarvie S, Crerar C, Ray JG. Abdominal visceral adiposity in the first trimester predicts glucose intolerance in later pregnancy. Diabetes Care 2009 Jul;32(7):1308-10. Epub 2009 Apr 23.

Massey KA, Magee LA, Dale S, Claydon J, Morris TJ, von Dadelszen P, Liston RM, Ansermino JM; Canadian Perinatal Network Collaborative Group (Whittle W) and the British Columbia Perinatal Health Program. A current landscape of provincial perinatal data collection in Canada. J Obstet Gynaecol Can 2009 Mar;31(3):236-46.

McDonald SD, Walker MC, Ohlsson A, Murphy KE, Beyene J, Perkins SL. The effect of tobacco exposure on maternal and fetal thyroid function. Eur J Obstet Gynecol Reprod Biol 2008 Sep;140(1):38-42. Epub 2008 Apr 18.

Metcalfe KA, Fan I, McLaughlin J, Risch HA, Rosen B, Murphy J, Bradley L, Armel S, Sun P, Narod SA. Uptake of clinical genetic testing for ovarian cancer in Ontario: A population-based study. Gynecol Oncol 2009 Jan;112(1):68-72. Epub 2008 Nov 20.

Metcalfe KA, Finch A, Poll A, Horsman D, Kim-Sing C, Scott J, Royer R, Sun P, Narod SA. Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation. Br J Cancer 2009 Jan 27;100(2):421-5. Epub 2008 Dec 16.

Miller E, Blaser S, Miller S, Keating S, Thompson M, Unger S, Toi A, Berger H, Chong K. Fetal MR imaging of atelosteogenesis type II (AO-II). Pediatr Radiol 2008 Dec;38(12):1345-9. Epub 2008 Aug 21.

30 PUBLICATIONS 2008-2009

Mousa NA, Crystal P, Wolfman WL, Bedaiwy MA, Casper RF. Aromatase inhibitors and mammographic breast density in postmenopausal women receiving hormone therapy. Menopause 2008 Sep-Oct;15(5):875-84.

Mu J, Slevin JC, Qu D, McCormick S, Adamson SL. In vivo quantification of embryonic and placental growth during gestation in mice using micro-ultrasound. BMC Reprod Biol Endocrinol 2008 Aug 12;6:34.

Murphy KE, Hannah ME, Willan AR, Hewson SA, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA; MACS Collaborative Group. Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet 2009 Dec 20;372(9656):2143-51.

Nam RK, Zhang WW, Trachtenberg J, Seth A, Klotz LH, Stanimirovic A, Punnen S, Venkateswaran V, Toi A, Loblaw DA, Sugar L, Siminovitch KA, Narod SA. Utility of incorporating genetic variants for the early detection of prostate cancer. Clin Cancer Res 2009 Mar 1;15(5):1787-93. Epub 2009 Feb 17.

Narod SA, Neuhausen S, Vichodez G, Armel S, Lynch HT, Ghadirian P, Cummings S, Olopade O, Stoppa-Lyonnet D, Couch F, Wagner T, Warner E, Foulkes WD, Saal H, Weitzel J, Tulman A, Poll A, Nam R, Sun P; Hereditary Breast Cancer Study Group, Danquah J, Domchek S, Tung N, Ainsworth P, Horsman D, Kim-Sing C, Maugard C, Eisen A, Daly M, McKinnon W, Wood M, Isaacs C, Gilchrist D, Karlan B, Nedelcu R, Meschino W, Garber J, Pasini B, Manoukian S, Bellati C. Rapid progression of prostate cancer in men with a BRCA2 mutation. Br J Cancer 2008 Jul 22;99(2):371-4. Epub 2008 Jun 24.

Neubauer NL, Havrilesky LJ, Calingaert B, Bulusu A, Bernardini MQ, Fleming ND, Bland AE, Secord AA. The role of lymphadenectomy in the management of preoperative grade 1 endometrial carcinoma. Gynecol Oncol 2009 Mar;112(3):511-6. Epub 2009 Jan 13.

Nguyen GC, Boudreau H, Harris ML, Maxwell CV. Outcomes of obstetric hospitalizations among women with inflammatory bowel disease in the United States. Clin Gastroenterol Hepatol 2009 Mar;7(3):329-34. Epub 2008 Oct 30.

Nofech-Mozes S, Khalifa MA, Ismiil N, Saad RS, Hanna WM, Covens A, Ghorab Z. Immunophenotyping of serous carcinoma of the female genital tract. Mod Pathol 2008 Sep;21(9):1147-55. Epub 2008 Jun 20.

Nofech-Mozes S, Trudeau M, Kahn HK, Dent R, Rawlinson E, Sun P, Narod SA, Hanna WM. Patterns of recurrence in the basal and non-basal subtypes of triple-negative breast cancers. Breast Cancer Res Treat 2009 Nov;118(1):131-7. Epub 2009 Feb 3.

Novak DJ, Chen LQ, Ghadirian P, Hamel N, Zhang P, Rossiny V, Cardinal G, Robidoux A, Tonin PN, Rousseau F, Narod SA, Foulkes WD. Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women. BMC Cancer 2008 Aug 15;8:239.

Okun N, Summers AM, Hoffman B, Huang T, Winsor E, Chitayat D, Staines A, Johnson JA. Prospective experience with integrated prenatal screening and first trimester combined screening for trisomy 21 in a large Canadian urban center. Prenat Diagn 2008 Nov;28(11):987-92.

31 PUBLICATIONS 2008-2009

Ortiz-Neira CL, Laffan E, Daneman A, Fong K, Roposch A, Ohlsson A, Jarrin J, Wang C, Wedge J, Doria AS. Colour Doppler ultrasound assessment of the normal neonatal hip. Can Assoc Radiol J 2009 Apr;60(2):79-87.

Oza AM, Eisenhauer EA, Elit L, Cutz JC, Sakurada A, Tsao MS, Hoskins PJ, Biagi J, Ghatage P, Mazurka J, Provencher D, Dore N, Dancey J, Fyles A. J Clin Oncol 2008 Sep 10;26(26):4319-25. Epub 2008 Jun 30.

Pal T, Keefe D, Sun P, Narod SA; the Hereditary Breast Cancer Clinical Study Group. Fertility in women with BRCA mutations: a case-control study. Fertil Steril 2009;112:68-72.

Pal T, Vadaparampil S, Betts J, Miree C, Li S, Narod SA. BRCA1/2 in high-risk African American women with breast cancer: Providing genetic testing through various recruitment strategies. Genet Test 2008 Sep;12(3):401-7.

Permuth-Wey J, Boulware D, Valkov N, Livingston S, Nicosia S, Lee JH, Sutphen R, Schildkraut J, Narod S, Parker A, Coppola D, Sellers T, Pal T. Sampling strategies for tissue microarrays to evaluate biomarkers in ovarian cancer. Cancer Epidemiol Biomarkers Prev 2009 Jan;18(1):28-34.

Pintilie M, Iakovlev V, Fyles A, Hedley D, Milosevic M, Hill RP. Heterogeneity and power in clinical biomarker studies. J Clin Oncol 2009 Mar 20;27(9):1517-21. Epub 2009 Feb 9. Erratum in: J Clin Oncol. 2009 Jun 1;27(16):2742.

Proctor LK, Dunk C, Baczyk D, Kingdom JC, Adamson SL. Early gene expression and morphogenesis of the murine chorioallantoic placenta in vivo and in vitro. Placenta 2009 Jan;30(1):96-104. Epub 2008 Nov 12.

Pru JK, Kaneko-Tarui T, Jurisicova A, Kashiwagi A, Selesniemi K, Tilly JL. Induction of proapoptotic gene expression and recruitment of p53 herald ovarian follicle loss caused by polycyclic aromatic hydrocarbons. Reprod Sci 2009 Apr;16(4):347-56. Epub 2008 Dec 15.

Quach S, Librach C. Infertility knowledge and attitudes in urban high school students. Fertil Steril 2008 Dec;90(6):2099-106. Epub 2008 Mar 5.

Quinn CE, Folkard C, Detmar J, Casper RF. Enhanced endocytotic and transcytotic activity in the rat endometrium prior to embryo implantation. J Mol Histol 2008 Aug;39(4):409-15. Epub 2008 Jun 29.

Rahman SA, Kollara A, Brown TJ, Casper RF. Selectively filtering short wavelengths attenuates the disruptive effects of nocturnal light on endocrine and molecular circadian phase markers in rats. Endocrinology 2008 Dec;149(12):6125-35. Epub 2008 Aug 7.

Ray J, Jurisicova A, Caniggia I. IFPA Trophoblast Research Award Lecture: The Dynamic Role of Bcl-2 Family Members in Trophoblast Cell Fate. Placenta 2009 Mar;30 Suppl A:S96-100. Epub 2008 Dec 17.

Ray JG, Jiang D, Sgro M, Shah R, Singh Gita, Mamdani MM. Thresholds for small for gestational age among newborns of East Asian and South Asian ancestry. J Obstet Gynaecol Can 2009 Apr;31(4):322-30. JOGC Apr 2009; 31(4):322-30.

32 PUBLICATIONS 2008-2009

Retnakaran R, Qi Y, Sermer M, Connelly PW, Hanley AJ, Zinman B. Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes. Diabetes Care 2008 Oct;31(10):2026-31. Epub 2008 Jul 15.

Retnakaran R, Qi Y, Sermer M, Connelly PW, Hanley AJ, Zinman B. The antepartum glucose values that predict neonatal macrosomia differ from those that predict postpartum prediabetes or diabetes: Implications for the diagnostic criteria for gestational diabetes. J Clin Endocrinol Metab 2009 Mar;94(3):840-5. Epub 2008 Dec 9.

Retnakaran R, Qi Y, Sermer M, Connelly PW, Zinman B, Hanley AJ. Isolated hyperglycemia at 1 hour on oral glucose tolerance test in pregnancy resembles gestational diabetes mellitus in predicting postpartum metabolic dysfunction. Diabetes Care 2008 Jul;31(7):1275-81. Epub 2008 Mar 20.

Retnakaran R, Qi Y, Sermer M, Connelly PW, Zinman B, Hanley AJ. Pre-gravid physical activity and reduced risk of glucose intolerance in pregnancy: the role of insulin sensitivity. Clin Endocrinol (Oxf) 2009 Apr;70(4):615-22. Epub 2008 Sep 12.

Revencu N, Boon LM, Mulliken JB, Enjolras O, Cordisco MR, Burrows PE, Clapuyt P, Hammer F, Dubois J, Baselga E, Brancati F, Carder R, Quintal JM, Dallapiccola B, Fischer G, Frieden IJ, Garzon M, Harper J, Johnson-Patel J, Labrèze C, Martorell L, Paltiel HJ, Pohl A, Prendiville J, Quere I, Siegel DH, Valente EM, Van Hagen A, Van Hest L, Vaux KK, Vicente A, Weibel L, Chitayat D, Vikkula M. Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations. Hum Mutat 2008 Jul;29(7):959-65.

Robinson AJ, Blaser S, Toi A, Chitayat D, Pantazi S, Keating S, Viero S, Ryan G. MRI of the fetal eyes: Morphologic and biometric assessment for abnormal development with ultrasonographic and clinicopathologic correlation. Pediatr Radiol 2008 Sep;38(9):971-81. Epub 2008 Jul 17.

Rodriguez RC, Esperon AA, Ropero R, Rubio MC, Rodriguez R, Ortiz RM, Anta JJ, de los Rios M, Carnesolta D, del Olivera MC, Vansam SS, Royer R, Akbari MR, Donenberg T, Narod SA. Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba. Fam Cancer 2008;7(3):275-9. Epub 2008 Feb 20.

Rogers IM, Yamanaka N, Casper RF. A simplified procedure for hematopoietic stem cell amplification using a serum-free, feeder cell-free culture system. Biol Blood Marrow Transplant 2008 Aug;14(8):927-37.

Rossant J, Tam PP. Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development 2009 Mar;136(5):701-13.

Rugg-Gunn PJ, Ogbogu U, Rossant J, Caulfield T. The challenge of regulating rapidly changing science: stem cell legislation in Canada. Cell Stem Cell 2009 Apr 3;4(4):285-8.

Rutsch F, Böyer P, Nitschke Y, Ruf N, Lorenz-Depierieux B, Wittkampf T, Weissen-Plenz G, Fischer RJ, Mughal Z, Gregory JW, Davies JH, Loirat C, Strom TM, Schnabel D, Nürnberg P, Terkeltaub R; GACI Study Group (Chitayat D). Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy. Circ Cardiovasc Genet 2008 Dec;1(2):133-40. 33 PUBLICATIONS 2008-2009

Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D. The fallopian tube: Primary site of most pelvic high-grade serous carcinomas. Int J Gynecol Cancer 2009 Jan;19(1):58-64.

Saposnik G, Ray JG, Sheridan P, McQueen M, Lonn E; Heart Outcomes Prevention Evaluation 2 Investigators. Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial. Stroke 2009 Apr;40(4):1365-72. Epub 2009 Feb 19.

Savasi I, Spitzer RF, Allen LM, Ornstein MP. Menstrual suppression for adolescents with developmental disabilities. J Ped Adol Gynecol 2009;22(3):143-149.

Schmidt M, Jaeggi E, Ryan G, Hyldebrandt J, Lilly J, Peirone A, Benson L, Chaturvedi RR. Percutaneous ultrasound-guided stenting of the atrial septum in fetal sheep. Ultrasound Obstet Gynecol 2008 Dec;32(7):923-8.

Schulz JA, Smith KM, Drutz HP. A review of the concordance of diagnoses made after multi- channel urodynamics and video urodynamics in women with urinary incontinence J Obstet Gynaecol Can 2009 Feb;31(2):156-60.

Selk A, Belej-Rak T, Shapiro H, Greenblatt E. Use of an oncology sperm bank: a Canadian experience. Can Urol Assoc J 2009 Jun;3(3):219-22.

Setiawan VW, Doherty JA, Shu XO, Akbari MR, Chen C, De Vivo I, Demichele A, Garcia- Closas M, Goodman MT, Haiman CA, Hankinson SE, Henderson BE, Horn-Ross PL, Lacey JV Jr, Le Marchand L, Levine DA, Liang X, Lissowska J, Lurie G, McGrath M, Narod SA, Rebbeck TR, Ursin G, Weiss NS, Xiang YB, Yang HP, Zheng W, Olson SH. Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium. Cancer Epidemiol Biomarkers Prev 2009 Jan;18(1):242-7.

Shah PS, Murthy P, Skidmore D, Shaffer LG, Bejjani BA, Chitayat D. Williams syndrome in a preterm infant with phenotype of Alagille syndrome. Am J Med Genet A 2008 Sep 15;146A(18):2407-11.

Shaw JL, Petraki C, Watson C, Bocking A, Diamandis EP. Role of tissue kallikrein-related peptidases in cervical mucus remodelling and host defense. Biol Chem 2008 Dec;389(12):1513- 22.

Sheshgiri R, Rao V, Tumiati LC, Xiao R, Prodger JL, Badiwala M, Librach C, Delgado DH. Progesterone induces human leukocyte antigen-g expression in vascular endothelial and smooth muscle cells. Circulation 2008 Sep 30;118(14 Suppl):S58-64.

Shynlova O, Tsui P, Dorogin A, Lye SJ. Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor. J Immunol 2008 Jul 15;181(2):1470-9.

Shynlova O, Tsui P, Jaffer S, Lye SJ. Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour. Eur J Obstet Gynecol Reprod Biol 2009 May;144 Suppl 1:S2-10. Epub 2009 Mar 18.

Simon-Bouy B, Taillandier A, Fauvert D, Brun-Heath I, Serre JL, Armengod CG, Bialer MG, Mathieu M, Cousin J, Chitayat D, Liebelt J, Feldman B, Gérard-Blanluet M, Körtge-Jung S, King C, Laivuori H, Le Merrer M, Mehta S, Jern C, Sharif S, Prieur F, Gillessen-Kaesbach G, 34 PUBLICATIONS 2008-2009

Zankl A, Mornet E. Hypophosphatasia: molecular testing of 19 prenatal cases and discussion about genetic counseling. Prenat Diagn 2008 Nov;28(11):993-8.

Singh SS, Marcoux V, Cheung V, Martin D, Ternamian AM. Core competencies for gynecologic endoscopy in residency training: A national consensus project. J Minim Invasive Gynecol 2009 Jan-Feb;16(1):1-7.

Sodek KL, Brown TJ, Ringuette MJ. Collagen I but not Matrigel matrices provide an MMP- dependent barrier to ovarian cancer cell penetration. BMC Cancer 2008 Aug 5;8:223.

Sodek KL, Evangelou AI, Ignatchenko A, Agochiya M, Brown TJ, Ringuette MJ, Jurisica I, Kislinger T. Identification of pathways associated with invasive behavior by ovarian cancer cells using multidimensional protein identification technology (MudPIT). Mol Biosyst 2008 Jul;4(7):762-73. Epub 2008 Apr 17.

Sodek KL, Ringuette MJ, Brown TJ. Compact spheroid formation by ovarian cancer cells is associated with contractile behavior and an invasive phenotype. Int J Cancer 2009 May 1;124(9):2060-70.

Song MS, Hu A, Dyhamenahali U, Chitayat D, Winsor EJ, Ryan G, Smallhorn J, Barrett J, Yoo SJ, Hornberger LK. Extracardiac lesions and chromosomal abnormalities associated with major fetal heart defects: Comparison of intrauterine, postnatal and postmortem diagnoses. Ultrasound Obstet Gynecol 2009 May;33(5):552-9.

Soraisham AS, Singhal N, McMillan DD, Sauve RS, Lee SK, Canadian Neonatal Network. A multicenter study on the clinical outcome of chorioamnionitis in preterm infants. Am J Obstet Gynecol 2009 Apr;200(4):372.e1-6. Epub 2009 Feb 14.

Sozo F, O'Day L, Maritz G, Kenna K, Stacy V, Brew N, Walker D, Bocking A, Brien J, Harding R. Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung. Am J Physiol Lung Cell Mol Physiol 2009 Mar;296(3):L510-8. Epub 2008 Dec 26.

Spitzer RF, Kives S, Ornstein M, Caccia N, Stephens D, Flood C, Allen LM. Videoconferencing for resident teaching of subspecialty topics: The Pediatric and Adolescent Gynecology experience at the Hospital for Sick Children. J Pediatr Adolesc Gynecol 2008 Dec;21(6):343-6.

Stevens B, McGrath P, Dupuis A, Gibbins S, Beyene J, Breau L, Camfield C, Finley GA, Franck LS, Howlett A, Johnston C, McKeever P, O'Brien K, Ohlsson A, Yamada J. Indicators of pain in neonates at risk for neurological impairment. J Adv Nurs 2009 Feb;65(2):285-96. Epub 2008 Nov 22.

Sword W, Watt S, Krueger P, Thabane L, Landy CK, Farine D, Swinton M. The Ontario Mother and Infant Study (TOMIS) III: A multi-site cohort study of the impact of delivery method on health, service use, and costs of care in the first postpartum year. BMC Pregnancy Childbirth 2009 Apr 28;9:16.

Tanaka M, Balki M, McLeod A, Carvalho JC. Regional anesthesia and non-preeclamptic thrombocytopenia: time to re-think the safe platelet count. Rev Bras Anestesiol 2009 Mar- Apr;59(2):142-53. 35 PUBLICATIONS 2008-2009

Teichert AM, Scott JA, Robb GB, Zhou YQ, Lem M, Keightley A, Steer BM, Schuh AC, Adamson SL, Cybulsky MI, Marsden PA. Endothelial nitric oxide synthase gene expression during murine embryogenesis: Commencement of expression in the embryo occurs with the establishment of a unidirectional circulatory system. Circ Res 2008 Jul 3;103(1):24-33.

Tomasini R, Tsuchihara K, Tsuda C, Lau SK, Wilhelm M, Ruffini A, Tsao MS, Iovanna JL, Jurisicova A, Melino G, Mak TW. TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci U S A 2009 Jan 20;106(3):797-802. Epub 2009 Jan 12.

Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung CC, Khan F, Itie-Youten A, Wakeham A, Tsao MS, Iovanna JL, Squire J, Jurisica I, Kaplan D, Melino G, Jurisicova A, Mak TW. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 2008 Oct 1;22(19):2677-91.

Tone AA, Begley H, Sharma M, Murphy J, Rosen B, Brown TJ, Shaw PA. Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high- grade serous carcinma. Clin Cancer Res 2008 Jul 1;14(13):4067-78.

Trottier H, Mahmud SM, Lindsay L, Jenkins D, Quint W, Wieting SL, Schuind A, Franco EL; GSK HPV-001 Vaccine Study Group (Shier M). Persistence of an incident human papillomavirus infection and timing of cervical lesions in previously unexposed young women. Cancer Epidemiol Biomarkers Prev 2009 Mar;18(3):854-62. Epub 2009 Feb 17.

Tzemos N, Silversides CK, Colman JM, Therrien J, Webb GD, Mason J, Cocoara E, Sermer M, Siu SC. Late cardiac outcomes after pregnancy in women with congenital aortic stenosis. Am Heart J 2009 Mar;157(3):474-80. van Haelst MM, Maiburg M, Baujat G, Jadeja S, Monti E, Bland E, Pearce K; Fraser Syndrome Collaboration Group (incl. Chitayat D), Hennekam RC, Scambler PJ. Molecular study of 33 families with Fraser syndrome new data and mutation review. Am J Med Genet A 2008 Sep 1;146A(17):2252-7.

Walsh CS, Ogawa S, Scoles DR, Miller CW, Kawamata N, Narod SA, Koeffler HP, Karlan BY. Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomas. Clin Cancer Res 2008 Dec 1;14(23):7645-51.

Wang C, Ryan G. Transfusion medicine illustrated: Intrauterine transfusion for homozygous alpha(0) thalassemia reverses hydrops fetalis. Transfusion 2009 Jun;49(6):1043-4.

Wathen CN, Jamieson E, MacMillan HL; McMaster Violence Against Women Research Group (Thomas J). Who is identified by screening for intimate partner violence? Womens Health Issues 2008 Nov-Dec;18(6):423-32.

Wilson RD, Johnson A, Ryan G. Current controversies in prenatal diagnosis 2: Should laser ablation of placental anastomoses be used in all cases of twin to twin transfusion? Prenat Diagn 2009 Jan;29(1):6-10.

Wise MR, Sadler L, Ansell D. Successful but limited use of external cephalic version in Auckland. Australian and New Zealand Journal of Obstetrics and Gynaecology October 2008;48:467-72. 36 PUBLICATIONS 2008-2009

Wokolorczyk D, Cybulski C, Gliniewicz B, Sikorski A, Zlowocka E, Masojc B, Debniak T, Matyjasik J, Mierzejewski M, Medrek K, Oszutowska D, Suchy J, Gronwald J, Huzarski T, Byrski T, Jakubowska A, Gorski B, Van de Wetering T, Walczak S, Narod SA, Lubinski J. A range of cancers associated with the rs6983267 marker on chromosome 8. Cancer Research 68:9982-6, 2008.

Wokołorczyk D, Lubiński J, Narod SA, Cybulski C. Genetic heterogeneity of 8q24 region in susceptibility to cancer. J Natl Cancer Inst 2009 Feb 18;101(4):278-9. Epub 2009 Feb 10.

Yeganegi M, Watson CS, Martins A, Kim SO, Reid G, Challis JR, Bocking AD. Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor. 2009 May;200(5):532.e1-8. Epub 2009 Mar 14.

Yie SM, Li LH, Xiao R, Librach CL. A single base-pair mutation in the 3'-untranslated region of HLA-G mRNA is associated with pre-eclampsia. Mol Hum Reprod 2008 Nov;14(11):649-53. Epub 2008 Oct 24

Young SR, Pilarski RT, Donenberg T, Shapiro C, Hammond LS, Miller J, Brooks KA, Cohen S, Tenenholz B, Desai D, Zandvakili I, Royer R, Li S, Narod SA. The prevalence of BRCA1 mutations among young women with triple-negative breast cancer. BMC Cancer 2009 Mar 19;9:86.

Yudin MH, Salaripour M, Sgro MD. Pregnant women's knowledge of influenza and the use and safety of the influenza vaccine during pregnancy. J Obstet Gynaecol Can 2009 Feb;31(2):120-5.

37 PUBLICATIONS 2008-2009

Invited Papers, Case Reports, Commentaries, Editorials, Reviews and Book Chapters

Al-Abdulrazzaq D, Allen LM. Pediatric and adolescent gynecology. In: The Hospital for Sick Children Handbook of Pediatrics, 11th ed, Toronto: Elsevier Canada, 2009.

Allen LM. Congentital gynaecological anomalies. In: Allen L, Bajpal M, et al. editors, Progress in Paediatric Urology, Vol. 11, New Delhi: Penwel Publishers, 2008, pp 165-85.

Allen LM. Disorders of sexual development. Obstetrics and Gynecology Clinics of North America. S. Paige Hertweck, Guest ed., 2009 March;36(1):25-45. Review.

Allen LM, Fleming N, Strickland J. Adnexal masses in neonates, children and adolescents. In: Clinical Pediatric and Adolescent Gynecology. Sanfilippo JS, Lara-Torre E, eds. London: Informa Healthcare, December 2008, pp 417-30.

Amir B, Farrell SA; Sub-Committee on Urogynaecology (Lovatsis D). SOGC Committee opinion on urodynamics testing. .J Obstet Gynaecol Can 2008 Aug;30(8):717-27.

Arbuckle TE, Hauser R, Swan SH, Mao CS, Longnecker MP, Main KM, Whyatt RM, Mendola P, Legrand M, Rovet J, Till C, Wad M, Jarell J, Matthews SG, Vliet GV, Bornehag C-G, Mieusset R. Meeting Report: Measuring endocrine-sensitive endpoints within the first years of life. Environ Health Perspect 2008 Jul;116(7):948-51.

Balki M, Dhumne S, Kasodekar S, Seaward G, Carvalho JCA. Blood transfusion for primary postpartum hemorrhage: A tertiary care hospital review. J Obstet Gynaecol Can Nov 2008;30(11):1002- 7.

Bambao C, Shier M. Extramammary Paget's disease of the vulva. J Obstet Gynaecol Can 2009 Jun;31(6):481, 482.

Berger H, Sermer M. Counterpoint: Selective screening for gestational diabetes mellitus. Diabetes Care 2009 Jul;32(7):1352-4.

Bernardini MQ, Murphy JK. Issues surrounding lymphadenectomy in the management of endometrial cancer. J Surg Oncol 2009 Mar 15;99(4):232-41. Review.

Buchanan JA, Carson AR, Chitayat D, Malkin D, Meyn MS, Ray PN, Shuman C, Weksberg R, Scherer SW. The cycle of genome-directed medicine. Genome Med. 2009 Feb 2;1(2):16

Caccia N. Menstrual disorders. In: Allen L, Bajpal M, et al. editors, Progress in Paediatric Urology, Vol. 11, New Delhi: Penwel Publishers, 2008, pp 68-92.

Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF 3rd, Petraglia F. Inflammation and pregnancy. Reprod Sci 2009 Feb;16(2):206-15. Review.

38 PUBLICATIONS 2008-2009

Cotter K, Sermer M. Monitoring fetal well-being in the critical care setting. In: Pulmonary problems in pregnancy: Clinical and research aspects. Rosene-Montella K, Bourjeily G, eds. New York: Humana Press, 2009.

Covens A, Kupets R, editors. Laparoscopic Surgery for Gynecologic Oncology. New York: McGraw Hill, 2009, 2008.

Derzko CM. Depo Medroxyprogesterone acetate : Update on bone effects. Osteoporosis Update. Winter 2009.

Derzko CM. Hormone therapy in early menopause. Women’s Health Issue, The Medical Post, September 26, 2008.

Derzko CM. Bioidentical Hormones. [email protected], January 2009.

Dodd JM, Sahi K, McLeod A, Windrim RC, Kingdom JP. Heparin therapy for complications of placental dysfunction: A systematic review of the literature. Acta Obstet Gynecol Scand 2008;87(8):804- 11. Review.

Dunk C, Huppertz B, Kingdom J. Development of the placenta and its circulation. In: Fetal Medicine: Basic Science and Clinical Practice. Eds: Rodeck CH, Whittle MJ. 2nd ed., London: Churchill Livingstone Elsevier, 2009, pp 69-96.

Dunk C, Smith S, Hazan A, Whittle W, Jones RL. Promotion of angiogenesis by human endometrial lymphocytes. Immunol Invest 2008;37(5):583-610. Review.

Farine D, Gagnon R, MFM Committee of the SOGC. Are we facing a crisis in maternal fetal medicine in Canada? J Obstet Gynaecol Can. 2008 Jul;30(7):598-9.

Gagnon AJ, Zimbeck M, Zeitlin J; ROAM Collaboration, Alexander S, Blondel B, Buitendijk S, Desmeules M, Di Lallo D, Gagnon A, Gissler M, Glazier R, Heaman M, Korfker D, Macfarlane A, Ng E, Roth C, Small R, Stewart D, Stray-Pederson B, Urquia M, Vangen S, Zeitlin J, Zimbeck M. Migration to western industrialised countries and perinatal health: A systematic review. Soc Sci Med 2009 Sep;69(6):934-46. Epub 2009 Aug 5. Review.

Giannoulias D. Menopause and Osteoporosis. Ultrasound in Gynaecology. Sponsored by True North Imaging. Quarterly, 2008-2009.

Gien LT, Covens A. Lymph node assessment in cervical cancer: Prognostic and therapeutic implications. J Surg Oncol 2009 Mar 15;99(4):242-7. Review.

Gien L, Covens A. Principles of Laparoscopic Surgery. In: European Society of Gynecologic Oncology Handbook, Ayhan A., Gultekin M, editors. Geneva: European Society of Gynecologic Oncology, 2009.

39 PUBLICATIONS 2008-2009

Hauspy J, Kupets R, Covens A. Miscellaneous, including Omentectomy, Appendectomy, Lysis of Adhesions, and Splenectomy. In: Covens A, Kupets R, editors. Laparoscopic Surgery for Gynecologic Oncology. New York: McGraw Hill, 2009, 2008.

Hinek A, Jain S, Taylor G, Nykanen D, Chitayat D. High copper levels and increased elastolysis in a patient with cutis marmorata teleangiectasia congenita. Am J Med Genet A 2008 Oct 1;146A(19):2520-7.

Jimenez W, Covens A. The role of cytoreductive surgery in cervical cancer: Is there a benefit of retroperitoneal lymph node debulking in advanced disease. In: Cytoreductive Surgery in Gynecologic Oncology Yildirim Y. ed. Trivandrum: Research Signpost, 2009.

Johnson N, Shah PS, Shannon P, Campisi P, Medd L, Windrim R, Ryan G. A challenging delivery by EXIT procedure of a fetus with a giant cervical teratoma. J Obstet Gynaecol Can 2009 Mar;31(3):267-71.

Karamu C, Spitzer RF. Destructive procedures in pregnancy – A review for African surgeons. December 2008: www.utoronto.ca/ois/SIA/2008/Destructive_procedures.htm.

Kepron C, Blumenthal A, Chitayat D, Cutz E, Superti-Furga A, Keating S. An autophagic vacuolar myopathy-like disorder presenting as nonimmune hydrops in a female fetus. Pediatr Dev Pathol 2009 Jan- Feb;12(1):53-8.

Khalifa MA, Smith A. Lymph node assessment: Issues in pathology. J Surg Oncol 2009 Mar 15;99(4):260-4. Review.

Kives S. Ovarian cysts. In: Allen L, Bajpal M, et al. editors, Progress in Paediatric Urology, Vol. 11, New Delhi: Penwel Publishers, 2008, pp 68-92.

Kives S, Spitzer RF. Adolescent contraception. In: Clinical Pediatric and Adolescent Gynecology. Sanfilippo JS, Lara-Torre E, eds. London: Informa Healthcare, December 2008, pp 229-53.

Koifman A, Shannon P, Kingdom J, Chitayat D. Diaphragmatic hernia and limb abnormalities syndrome (Froster syndrome). Clin Dysmorphol 2009 Jul;18(3):151-3.

Koifman A, Nevo O, Toi A, Chitayat C. Diagnostic approach to prenatally diagnosed limb abnormalities. Ultrasound Clin October 2008;3(4):595-608.

Kotaska A, Menticoglou S, Gagnon R, Farine D, Basso M, Bos H, Delisle MF, Grabowska K, Hudon L, Mundle W, Murphy-Kaulbeck L, Ouellet A, Pressey T, Roggensack A; Maternal Fetal Medicine Committee; Society of Obstetricians and Gynaecologists of Canada. Vaginal delivery of breech presentation. J Obstet Gynaecol Can 2009 Jun;31(6):557-66, 567-78.

Kupets R, Covens A. The Role of Laparoscopy in Gynecologic Oncology. In: Covens A, Kupets R, editors. Laparoscopic Surgery for Gynecologic Oncology. New York: McGraw Hill, 2009, 2008.

Lambe EK, George TP. Perspective: Translational studies on glutamate and dopamine neurocircuitry in addictions: Implications for addiction treatment. Neuropsychopharmacology. 2009 Jan;34(2):255-6. Epub 2008 Nov 5.

Lambe EK, Aghajanian GK. Using basic electrophysiology to understand the neurobiology of mental illness. In: Charney D, Nestler E, editors. Neurobiology of Mental Illness, 3rd ed. London: Oxford University Press, 2008, pp 29-40. 40 PUBLICATIONS 2008-2009

Laskin MD, Tessler K, Kives S. Cecal perforation due to paralytic ileus following primary caesarean section. J Obstet Gynaecol Can 2009 Feb;31(2):167-71.

Leyland N. Abnormal uterine bleeding in premenopausal women. June 2009; 21(6).

Lie K. Beyond cramps. Glow Magazine, November 2009.

Liu KE, Binsaleh S, Lo KC, Jarvi K. Propecia-induced spermatogenic failure: a report of two cases. Fertil Steril 2008 Sep;90(3):849.e17-9. Epub 2007 Dec 11.

Liu K, Greenblatt E. Ovarian hyperstimulation syndrome. In: The 5-Minute Clinical Consult. 17th ed., 2009. Domino FJ, Baldor RA, Ehrlich AM, Golding J, eds. Philadelphia:Lippincott, Williams and Wilkins, 2008.

Lunt SJ, Fyles A, Hill RP, Milosevic M. Interstitial fluid pressure in tumors: therapeutic barrier and biomarker of angiogenesis. Future Oncol 2008 Dec;4(6):793-802. Review.

Mains L, Ryan G, Sparks A, Van Voorhis B. Sextuplets: an unusual complication of single embryo transfer. Fertil Steril 2009 Mar;91(3):932.e1-2. Epub 2008 Oct 30.

Maxwell C, McGeer A, Tai KFY, Sermer M, Maternal Fetal Medicine Committee (Farine D), Infectious Disease Committee (Yudin M, Murphy K). Management guidelines for obstetric patients and neonates born to mothers with suspected or probable SARS. SOGC Clinical Practice Guideline, No. 225, 2009 Apr; 358-9.

Newnham JP, Pennell CE, Lye SJ, Rampono J, Challis JR. Early life origins of obesity. Obstet Gynecol Clin North Am 2009 Jun;36(2):227-44, xii. Review.

Ornstein M. Androgen excess disorders. In: Allen L, Bajpal M, et al. editors, Progress in Paediatric Urology, Vol. 11, New Delhi: Penwel Publishers, 2008, pp 93-110.

Percy M. Welcome to the Journal on Developmental Disabilities and Volume 14. J Dev Disabilities 2008;14(3): v-ix.

Percy M. Welcome to the Journal on Developmental Disabilities and Volume 15. J Dev Disabilities 2009; 15(1):v-xii.

Pennell CE, Palmer LJ, Knight BS, Relton C, Lye SJ. Approaches to evaluate gene-environment interactions underlying the developmental origins of health and disease. In: Early Life Origins of Human Health and Disease. Newnham JP, Ross MG, editors, Basel: Karger, 2009, pp. 205-17.

Pfeifer SM, Kives S. Polycystic ovary syndrome in the adolescent. Obstet Gynecol Clin North Am 2009 Mar;36(1):129-52. Review.

Quinn CE, Casper RF. Pinopodes: a questionable role in endometrial receptivity. Hum Reprod Update 2009 Mar-Apr;15(2):229-36. Epub 2008 Nov 8. Review. 41 PUBLICATIONS 2008-2009

Reid RL, Blake J, Abramson B, Khan A, Senikas V, Fortier M. Menopause and Osteoporosis Update 2009. SOGC Clinical Practice Guideline, No. 222. J Obstet Gynaecol Can 2009 Jan;31(1) Supp 1:S1-45.

Roggensack A, Jefferies AL, Farine D. Management of Meconium at Birth. SOGC Technical Update, No 224. J Obstet Gynaecol Can 2009 Apr; 31(4):353-4.

Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D. The fallopian tube: primary site of most pelvic high-grade serous carcinomas. Int J Gynecol Cancer 2009 Jan;19(1):58-64. Review.

Schulz JA, Chan MC, Farrell SA; Sub-Committee on Urogynaecology (Lovatsis D). Midurethral minimally invasive sling procedures for stress urinary incontinence. J Obstet Gynaecol Can 2008 Aug;30(8):728-40.

Schulz JA, Smith KM, Drutz HP. A review of the concordance of diagnoses made after multi-channel urodynamics and video urodynamics in women with urinary incontinence J Obstet Gynaecol Can 2009 Feb;31(2):156-60.

Shah PS, Zhang K, Lee SK on behalf of the Database and Annual Report Committee of the Canadian Neonatal Network. Annual Report of the Canadian Neonatal Network, 2007, Canadian Neonatal Network, 2008.

Shore E, Kingdom J, Windrim R. Spontaneous uterine rupture. J Obstet Gynecol Can 2009 May;31(5):395, 396.

Silversides CK, Siu SC, Sermer M, Colman JM. Management of congenital heart disease in pregnancy. Paediatric Cardiology, 3rd ed. Anderson RH, Baker EJ, Penny D, Redington AN, Rigby ML, Wernovsky G, eds. Philadelphia: Churcill Livingstone, Chapter 60.

Spitzer RF, Caccia N, Kives S, Allen LM. Hysteroscopic unification of a complete obstructing uterine septum: case report and review of the literature. Fertil Steril 2008 Nov;90(5):2016.e17-20. Epub 2008 Mar 6. Review.

Spitzer RF, Kives S, Allen LM. Case series of laparoscopically resected noncommunicating functional uterine horns. J Pediatr Adolesc Gynecol 2009 Feb;22(1):e23-8.

Spitzer RF, Kives S, Caccia N, Ornstein M, Goia C, Allen LM. Retrospective review of unintentional female genital trauma at a pediatric referral center. Pediatr Emerg Care 2008 Dec;24(12):831-5. Review.

Spitzer RF. Genital trauma. In: Allen L, Bajpal M, et al. editors, Progress in Paediatric Urology, Vol. 11, New Delhi: Penwel Publishers, 2008, pp 14-27.

Taddio A, Crosdale B, Hogan ME, El Sayed MF, Lee KS, Moore AM, Shah V. Safety of morphine in nonintubated infants in the neonatal intensive care unit. Clin J Pain 2009 Jun;25(5):418-22.

Terblanche N, Maxwell C, Keunen J, Carvalho JC. Obstetric and anesthetic management of severe congenital myasthenia syndrome. Anesth Analg 2008 Oct;107(4):1313-5. 42 PUBLICATIONS 2008-2009

Thompson MD, Cole DE, Ray JG. Vitamin B-12 and neural tube defects: the Canadian experience. Am J Clin Nutr 2009 Feb;89(2):697S-701S. Epub 2008 Dec 30. Review.

Thompson MD, Percy ME, McIntyre Burnham W, Cole DE. G protein-coupled receptors disrupted in human genetic disease. Methods Mol Biol 2008;448:109-37. Review.

Toi A, Chitayat D, Blaser S. Abnormalities of the foetal cerebral cortex. Prenat Diagn 2009 Apr;29(4):355-71. Review.

Tsangaris E, Adams SL, Yoon G, Chitayat D, Lansdorp P, Dokal I, Dror Y. Ataxia and pancytopenia caused by a mutation in TINF2. Hum Genet 2008 Dec;124(5):507-13. Epub 2008 Nov 1.

Vilos GA, Urian R, Chang P, Kozak R. Femoral artery puncture site pseudoaneurysm formation following uterine artery embolization for symptomatic fibroids: A case report. J Obstet Gynaecol Can 2009 Mar;31(3):263-6. Wallace S, Herer E, Kiraly J, Valikangas E, Rahmani R. A wandering spleen: unusual cause of a pelvic mass. Obstet Gynecol 2008 Aug;112(2 Pt 2):478-80.

Yudin MH, Kaul R. Progressive hypertrophic genital herpes in an HIV-infected woman despite immune recovery an antiretroviral therapy. Infect Dis Obstet Gynecol 2008;2008:Article ID 592532. Published online 2008 September 4. doi: 10.1155/2008/592532.

Yudin MH, Money DM; Infectious Diseases Committee. Screening and management of bacterial vaginosis in pregnancy. J Obstet Gynaecol Can 2008 Aug;30(8):702-16.

Yudin MH, Romanowski B, Leduc D.Virtual practice: Prevention of cervical cancer through vaccination. MD Briefcase Online Continuing Medical Education Case. www.mdbriefcase.com, 2008.

Zolis L, Shier M. Vulvar intraepithelial neoplasia (erythroplasia of Queyrat). J Obstet Gynaecol Can 2008 Aug;30(8):647-8.

43 PUBLICATIONS 2009-2010

PEER-REVIEWED PUBLICATIONS 2009-2010 Original Research

Aggarwal A, Lucco KL, Lacy J, Kives S, Gerstle JT, Allen L. Ovarian epithelial tumors of low malignant potential: A case series of 5 adolescent patients. J Pediatr Surg 2009 Oct;44(10):2023-7.

Ahmad F, Driver N, McNally MJ, Stewart DE. “Why doesn't she seek help for partner abuse?” An exploratory study with South Asian immigrant women. Soc Sci Med 2009 Aug;69(4):613-22. Epub 2009 Jul 2.

Ahmad F, Hogg-Johnson S, Stewart DE, Skinner HA, Glazier RH, Levinson W. Computer-assisted screening for intimate partner violence and control: A randomized trial. Ann Intern Med 2009 Jul 21;151(2):93-102. Epub 2009 Jun 1.

Ahmad F, Skinner HA, Stewart DE, Levinson W. Perspectives of family physicians on computer- assisted health-risk assessments. J Med Internet Res 2010 May 7;12(2):e12.

Ahmed K, Dehghani H, Rugg-Gunn P, Fussner E, Rossant J, Bazett-Jones DP. Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One 2010 May 7;5(5):e10531.

Ai J, Esfandiari N, Casper RF. Detection of aromatase in human endometrial tissue cultured in three- dimensional fibrin matrix in vitro. Iran J Reprod Med 2009;7(3):105-9.

Ai J, Esfandiari N, Casper R. Secretion of vascular endothelial growth factor in a three-dimensional culture of human endometrium; An in-vitro model for endometriosis. J Reprod Infertil 2009;10(2):158.

Al-Saleh S, Mei-Zahav M, Faughnan ME, MacLusky IB, Carpenter S, Letarte M, Ratjen F. Screening for pulmonary and cerebral arteriovenous malformations in children with hereditary haemorrhagic telangiectasia. Eur Respir J 2009 Oct;34(4):875-81. Epub 2009 Apr 22.

Armel SR, McCuaig J, Finch A, Demsky R, Panzarella T, Murphy J, Rosen B. The effectiveness of family history questionnaires in cancer genetic counseling. J Genet Couns 2009 Aug;18(4):366-78. Epub 2009 May 21.

Audette MC, Greenwood SL, Sibley CP, Jones CJ, Challis JR, Matthews SG, Jones RL. Dexamethasone stimulates placental system A transport and trophoblast differentiation in term villous explants. Placenta 2010 Feb;31(2):97-105. Epub 2009 Dec 31.

Balki M, Cristian AL, Kingdom J, Carvalho JC. Oxytocin pretreatment of pregnant rat myometrium reduces the efficacy of oxytocin but not of ergonovine maleate or prostaglandin F 2 alpha. Reprod Sci 2010 Mar;17(3):269-77. Epub 2010 Feb 2.

Barata P, Stewart DE. Searching for housing as a battered woman: Does discrimination affect reported availability of a rental unit? Psychology of Women Quarterly. March 2010; 34(1): 43-55. 44 PUBLICATIONS 2009-2010

Barnea O, Luria O, Jaffa A, Stark M, Fox HE, Farine D. Relations between fetal head descent and cervical dilatation during individual uterine contractions in the active stage of labor. J Obstet Gynaecol Res 2009 Aug;35(4):654-9.

Basel-Vanagaite L. Shaffer L. Chitayat D. Keppen-Lubinsky syndrome: Expanding the phenotype. Am J Med Genet A. 149A(8):1827-9, 2009 Aug.

Bedaiwy MA, Mousa NA, Casper RF. Aromatase inhibitors: Potential reproductive implications. J Minim Invasive Gynecol 2009 Sep-Oct;16(5):533-9. Epub 2009 Jul 15.

Bedaiwy MA, Ryan E, Shaaban O, Claessens EA, Nasr A, Sandadi S, Blanco Mejia S, Casper RF. Pregnancy outcome after metformin co-treatment in ovulation induction. Middle East Fertility Society Journal 2009;14(4).

Belik J, Jerkic M, McIntyre BA, Pan J, Leen J, Yu LX, Henkelman RM, Toporsian M, Letarte M. Age- dependent endothelial nitric oxide synthase uncoupling in pulmonary arteries of endoglin heterozygous mice. Am J Physiol Lung Cell Mol Physiol 2009 Dec;297(6):L1170-8. Epub 2009 Oct 9.

Belsham DD, Fick LJ, Dalvi PS, Centeno ML, Chalmers JA, Lee PK, Wang Y, Drucker DJ, Koletar MM. Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons. FASEB J 2009 Dec;23(12):4256-65. Epub 2009 Aug 24.

Bentov Y, Esfandiari N, Burstein E, Casper RF. The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Fertil Steril 2010 Jan;93(1):272-5. Epub 2009 Sep 3.

Bernardini MQ, Baba T, Lee PS, Barnett JC, Sfakianos GP, Secord AA, Murphy SK, Iversen E, Marks JR, Berchuck A. Expression signatures of TP53 mutations in serous ovarian cancers. BMC Cancer 2010 May 26;10:237.

Bernardini MQ, May T, Khalifa MA, Bland AE, Nofech-Mozes S, Berchuck A, Covens A, Havrilesky L. Evaluation of two management strategies for preoperative grade 1 endometrial cancer. Obstet Gynecol 2009 Jul;114(1):7-15.

Bhaduri M, Fong K, Toi A, Tomlinson G, Okun N. Fetal anatomic survey using three-dimensional ultrasound in conjunction with first-trimester nuchal translucency screening. Prenat Diagn 2010 Mar;30(3):267-73.

Borges BC, Wieczorek P, Balki M, Carvalho JC. Sonoanatomy of the lumbar spine of pregnant women at term. Reg Anesth Pain Med 2009 Nov-Dec;34(6):581-5.

Braun T, Li S, Sloboda DM, Li W, Audette MC, Moss TJ, Matthews SG, Polglase G, Nitsos I, Newnham JP, Challis JR. Effects of maternal dexamethasone treatment in early pregnancy on pituitary-adrenal axis in fetal sheep. Endocrinology 2009 Dec;150(12):5466-77. Epub 2009 Oct 21.

Brenner DR, Hung RJ, Tsao MS, Shepherd FA, Johnston MR, Narod S, Rubenstein W, McLaughlin JR. Lung cancer risk in never-smokers: a population-based case-control study of epidemiologic risk factors. BMC Cancer 2010 Jun 14;10(1):285. [Epub ahead of print] Brual J, Gravely-Witte S, Suskin N, Stewart DE, Macpherson A, Grace SL. Drive time to cardiac rehabilitation: at what point does it affect utilization? Int J Health Geogr 2010 Jun 4;9:27.

45 PUBLICATIONS 2009-2010

Cash R, Manogaran M, Sroka H, Okun N. An assessment of women's knowledge of and views on the reporting of ultrasound soft markers during the routine anatomy ultrasound examination. J Obstet Gynaecol Can 2010 Feb;32(2):120-5.

Casper RF. Letrozole versus clomiphene citrate: Which is better for ovulation induction? Fertil Steril 2009 Sep;92(3):858-9. Epub 2007 Jun 27.

Cavalli R, Bisazza A, Rolfo A, Balbis S, Madonnaripa D, Caniggia I, Guiot C. Ultrasound-mediated oxygen delivery from chitosan nanobubbles. Int J Pharm 378(1-2):215-7, 2009 Aug 13.

Chamberlain S, Bocking A, McGrath M, Faught W, Liston R, Wilson RD, Morris M, Sagle P, Armson A, O'Grady T, Richardson B. Teaching pelvic examinations under anaesthesia: What do women think? J Obstet Gynaecol Can 2010 Jun;32(6):539-40.

Chen Y, Hao Q, Kim H, Su H, Letarte M, Karumanchi SA, Lawton MT, Barbaro NM, Yang GY, Young WL. Soluble endoglin modulates aberrant cerebral vascular remodeling. Ann Neurol 2009 Jul;66(1):19-27.

Cheung S, Fick LJ, Belsham DD, Thompson M. Depolarization of surface-attached hypothalamic mouse neurons studied by acoustic wave (thickness shear mode) detector. Analyst 2010 Feb;135(2):289-95. Epub 2009 Dec 21.

Chitayat D, Glanc P. Diagnostic approach in prenatally detected genital abnormalities. Ultrasound Obstet Gynecol. 2010 Jun;35(6):637-46.

Chopra S, Foltz WD, Milosevic MF, Toi A, Bristow RG, Ménard C, Haider MA. Comparing oxygen- sensitive MRI (BOLD R2*) with oxygen electrode measurements: a pilot study in men with prostate cancer. Int J Radiat Biol 2009 Sep;85(9):805-13.

Costello JF, Moore AR, Wieczorek PM, Macarthur AJ, Balki M, Carvalho JC. The transversus abdominis plane block, when used as part of a multimodal regimen inclusive of intrathecal morphine, does not improve analgesia after cesarean delivery. Reg Anesth Pain Med 2009 Nov-Dec;34(6):586-9.

Cummings SR, Ensrud K, Delmas PD, LaCroix AZ, Vukicevic S, Reid DM, Goldstein S, Sriram U, Lee A, Thompson J, Armstrong RA, Thompson DD, Powles T, Zanchetta J, Kendler D, Neven P, Eastell R; PEARL Study Investigators (Colgan TJ). Lasofoxifene in postmenopausal women with osteoporosis. N Engl J Med 2010 Feb 25;362(8):686-96. Dennis J, Ghadirian P, Little J, Lubinski J, Gronwald J, Kim-Sing C, Foulkes W, Moller P, Lynch HT, Neuhausen SL, Domchek S, Armel S, Isaacs C, Tung N, Sweet K, Ainsworth P, Sun P, Krewski D, Narod S; the Hereditary Breast Cancer Clinical Study Group. Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. Breast 2010 Jun 11. [Epub ahead of print]

46 PUBLICATIONS 2009-2010

Dhillon SS, Gingerich S, Belsham DD. Neuropeptide Y induces gonadotropin-releasing hormone gene expression directly and through conditioned medium from mHypoE-38 NPY neurons. Regul Pept 2009 Aug 7;156(1-3):96-103. Epub 2009 Apr 14.

Ding X, Mohd AB, Huang Z, Baba T, Bernardini MQ, Lyerly HK, Berchuck A, Murphy SK, Buermeyer AB, Devi GR. MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition. Br J Cancer 2009 Jul 21;101(2):269-77.

Djordjevic B, Gien LT, Covens A, Malpica A, Khalifa MA. Polypoid or non-polypoid? A novel dichotomous approach to uterine carcinosarcoma. Gynecol Oncol 2009 Oct;115(1):32-6. Epub 2009 Jul 28.

Dong X, Yu C, Shynlova O, Challis JR, Rennie PS, Lye SJ. p54nrb is a transcriptional corepressor of the progesterone receptor that modulates transcription of the labor-associated gene, connexin 43 (Gja1). Mol Endocrinol 23(8):1147-60, 2009 Aug.

Dunn E, Kapoor A, Leen J, Matthews SG. Prenatal synthetic glucocorticoid exposure alters hypothalamic-pituitary-adrenal regulation and pregnancy outcomes in mature female guinea pigs. J Physiol 2010 Mar 1;588(Pt 5):887-99. Epub 2010 Jan 11.

Ferguson SE, Malhotra T, Seshan VE, Levine DA, Sonoda Y, Chi DS, Barakat RR, Abu-Rustum NR. A prospective randomized trial comparing patient-controlled epidural analgesia to patient-controlled intravenous analgesia on postoperative pain control and recovery after major open gynecologic cancer surgery. Gynecol Oncol 2009 Jul;114(1):111-6. Epub 2009 Apr 23.

Fernandez BA, Roberts W, Chung B, Weksberg R, Meyn S, Szatmari P, Joseph-George AM, Mackay S, Whitten K, Noble B, Vardy C, Crosbie V, Luscombe S, Tucker E, Turner L, Marshall CR, Scherer SW. Phenotypic spectrum associated with de novo and inherited deletions and duplications at 16p11.2 in individuals ascertained for diagnosis of autism spectrum disorder. J Med Genet 2010 Mar;47(3):195-203. Epub 2009 Sep 15.

Foulkes WD, Reis-Filho JS, Narod SA.Tumor size and survival in breast cancer--a reappraisal. Nat Rev Clin Oncol 2010 Jun;7(6):348-53. Epub 2010 Mar 23.

Fridovich-Keil JL, Sanders RD, Spencer JB, Epstein MP, Lustbader JW, Vardhana [Sharma] PA. Measures of ovarian function in galactosemia. Fertil Steril 2009 Aug;92(2):e30; author reply e31.

Gertsenstein M, Nutter LM, Reid T, Pereira M, Stanford WL, Rossant J, Nagy A. Efficient generation of germ line transmitting chimeras from C57BL/6N ES cells by aggregation with outbred host embryos. PLoS One 2010 Jun 22;5(6):e11260.

Gien LT, Barbera L, Kupets R, Saskin R, Paszat L. Utilization of preoperative imaging in uterine cancer patients. Gynecol Oncol 2009 Nov;115(2):226-30. Epub 2009 Aug 15.

Gien LT, Mackay HJ. The emerging role of PARP inhibitors in the treatment of epithelial ovarian cancer. J Oncol 2010;2010:151750. Epub 2009 Dec 16.

47 PUBLICATIONS 2009-2010

Gingerich S, Wang X, Lee PK, Dhillon SS, Chalmers JA, Koletar MM, Belsham DD. The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin-inhibitory hormone neurons. Neuroscience 2009 Sep 15;162(4):1134-40. Epub 2009 May 20.

Giuffrida D, Rogers IM, Nagy A, Calogero AE, Brown TJ, Casper RF. Human embryonic stem cells secrete soluble factors that inhibit cancer cell growth. Cell Prolif 2009 Dec;42(6):788-98. Epub 2009 Sep 1.

GlaxoSmithKline Vaccine HPV-007 Study Group, Romanowski B, de Borba PC, Naud PS, Roteli- Martins CM, De Carvalho NS, Teixeira JC, Aoki F, Ramjattan B, Shier RM, Somani R, Barbier S, Blatter MM, Chambers C, Ferris D, Gall SA, Guerra FA, Harper DM, Hedrick JA, Henry DC, Korn AP, Kroll R, Moscicki AB, Rosenfeld WD, Sullivan BJ, Thoming CS, Tyring SK, Wheeler CM, Dubin G, Schuind A, Zahaf T, Greenacre M, Sgriobhadair A. Sustained efficacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: analysis of a randomised placebo-controlled trial up to 6.4 years. Lancet 2009 Dec 12;374(9706):1975-85. Epub.

Gortzak-Uzan L, Jimenez W, Nofech-Mozes S, Ismiil N, Khalifa MA, Dubé V, Rosen B, Murphy J, Laframboise S, Covens A. Sentinel lymph node biopsy vs. pelvic lymphadenectomy in early stage cervical cancer: Is it time to change the gold standard? Gynecol Oncol 2010 Jan;116(1):28-32. Epub 2009 Oct 28.

Grafodatskaya D, Choufani S, Ferreira JC, Butcher DT, Lou Y, Zhao C, Scherer SW, Weksberg R. EBV transformation and cell culturing destabilizes DNA methylation in human lymphoblastoid cell lines. Genomics 2010 Feb;95(2):73-83. Epub 2009 Dec 18.

Gravely-Witte S, Stewart DE, Suskin N, Grace SL. The association among depressive symptoms, smoking status and antidepressant use in cardiac outpatients. J Behav Med 2009 Oct;32(5):478-90. Epub 2009 Jun 6.

Grewal K, Leung YW, Safai P, Stewart DE, Anand S, Gupta M, Parsons C, Grace SL. Access to cardiac rehabilitation among South-Asian patients by referral method: A qualitative study. Rehabil Nurs 2010 May-Jun;35(3):106-12.

Grewal J, Siu SC, Ross HJ, Mason J, Balint OH, Sermer M, Colman JM, Silversides CK. Pregnancy outcomes in women with dilated cardiomyopathy. J Am Coll Cardiol 2009 Dec 29;55(1):45- 52.

Grewal K, Stewart DE, Grace SL. Differences in social support and illness perceptions among South Asian and Caucasian patients with coronary artery disease. Heart Lung 2010 May-Jun;39(3):180-7. Epub 2009 Sep 3.

Grigoriadis S, Barrett J, Pittini R, Herer E, Zaltz A, Bazinet RP, Bradley L, Kennedy S, Steiner M, Levitt A. Omega-3 supplements in pregnancy: are we too late to identify the possible benefits? J Obstet Gynaecol Can. 2010 Mar;32(3):209-16.

Grossman SL, Lovatsis D. Overactive Bladder: Correlating symptoms with low cystometric capacity. Female Pelvic Med Reconstruct Surg 16(3):158-163, May/June 2010.

48 PUBLICATIONS 2009-2010

Gucciardi E, Vogt JA, DeMelo M, Stewart DE. Exploration of the relationship between household food insecurity and diabetes in Canada. Diabetes Care 2009 Dec;32(12):2218-24. Epub 2009 Aug 31.

Gunby J, Bissonnette F, Librach C, Cowan L; IVF Directors Group of the Canadian Fertility and Andrology Society. Assisted reproductive technologies (ART) in Canada: 2006 results from the Canadian ART Register. Fertil Steril 2010 May 1;93(7):2189-201. Epub 2009 May 12.

Hartley JL, Zachos NC, Dawood B, Donowitz M, Forman J, Pollitt RJ, Morgan NV, Tee L, Gissen P, Kahr WH, Knisely AS, Watson S, Chitayat D, Booth IW, Protheroe S, Murphy S, de Vries E, Kelly DA, Maher ER. Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy). Gastroenterology 2010 Jun;138(7):2388-98, 2398.e1-2. Epub 2010 Feb 20.

Herschorn S, Stothers L, Carlson K, Egerdie B, Gajewski JB, Pommerville P, Schulz J, Radomski S, Drutz H, Barkin J, Paradiso-Hardy F. Tolerability of 5 mg solifenacin once daily versus 5 mg oxybutynin immediate release 3 times daily: results of the VECTOR trial. J Urol 2010 May;183(5):1892-8. Epub 2010 Mar 29.

Hirji A, Bernasconi A, McCrindle BW, Dunn E, Gurofsky R, Manlhiot C, Miner SE, Kingdom JC, Jaeggi ET, Van Arsdell G, Nield LE. Outcomes of prenatally diagnosed tetralogy of Fallot: Implications for valve-sparing repair versus transannular patch. Can J Cardiol 2010 Jan;26(1):e1-6.

Holtzman S, Abbey SE, Stewart DE, Ross HJ. Pain after heart transplantation: Prevalence and implications for quality of life. Psychosomatics 2010 May;51(3):230-6.

Horike S, Ferreira JC, Meguro-Horike M, Choufani S, Smith AC, Shuman C, Meschino W, Chitayat D, Zackai E, Scherer SW, Weksberg R. Screening of DNA methylation at the H19 promoter or the distal region of its ICR1 ensures efficient detection of chromosome 11p15 epimutations in Russell-Silver syndrome. Am J Med Genet A 2009 Nov;149A(11):2415-23.

Huang T, Hoffman B, Meschino W, Kingdom J, Okun N. Prediction of adverse pregnancy outcomes by combinations of first and second trimester biochemistry markers used in the routine prenatal screening of Down syndrome. Prenat Diagn 2010 May;30(5):471-7.

Hutson JR, Koren G, Matthews SG. Placental P-glycoprotein and breast cancer resistance protein: influence of polymorphisms on fetal drug exposure and physiology. Placenta 2010 May;31(5):351-7. Epub 2010 Mar 27.

Illsley NP, Caniggia I, Zamudio S. Placental metabolic reprogramming: do changes in the mix of energy- generating substrates modulate fetal growth? Int J Dev Biol 2010;54(2-3):409-19.

Ito CY, Kirouac DC, Madlambayan GJ, Yu M, Rogers I, Zandstra PW. The AC133+CD38-, but not the rhodamine-low, phenotype tracks LTC-IC and SRC function in human cord blood ex vivo expansion cultures. Blood 2010 Jan 14;115(2):257-60. Epub 2009 Nov 6.

Jaeggi E, Laskin C, Hamilton R, Kingdom J, Silverman E. The importance of the level of maternal anti- Ro/SSA antibodies as a prognostic marker of the development of cardiac neonatal lupus erythematosus a prospective study of 186 antibody-exposed fetuses and infants. J Am Coll Cardiol 2010 Jun 15;55(24):2778-84.

Jaffer S, Shynlova O, Lye S. Mammalian target of rapamycin is activated in association with myometrial proliferation during pregnancy. Endocrinology 2009 Oct;150(10):4672-80. Epub 2009 Jul 9. 49 PUBLICATIONS 2009-2010

Jaragh M, Carydis VB, MacMillan C, Freeman J, Colgan TJ. Predictors of malignancy in thyroid fine- needle aspirates "cyst fluid only" cases: can potential clues of malignancy be identified? Cancer Cytopathol 2009 Oct 25;117(5):305-10.

Jiménez W, Paszat L, Kupets R, Wilton A, Tinmouth J. Presumed previous human papillomavirus (HPV) related gynecological cancer in women diagnosed with anal cancer in the province of Ontario. Gynecol Oncol 2009 Sep;114(3):395-8. Epub 2009 Jun 5.

Johnston JJ, Teer JK, Cherukuri PF, Hansen NF, Loftus SK; NIH Intramural Sequencing Center, Chong K, Mullikin JC, Biesecker LG. Massively parallel sequencing of exons on the X chromosome identifies RBM10 as the gene that causes a syndromic form of cleft palate. Am J Hum Genet 2010 May 14;86(5):743-8. Epub 2010 May 6.

Kalabis GM, Petropoulos S, Gibb W, Matthews SG. Multidrug resistance phosphoglycoprotein (ABCB1) expression in the guinea pig placenta: developmental changes and regulation by betamethasone. Can J Physiol Pharmacol 2009 Nov;87(11):973-8.

Kayaniyil S, Gravely-Witte S, Stewart DE, Higginson L, Suskin N, Alter D, Grace SL. Degree and correlates of patient trust in their cardiologist. J Eval Clin Pract 2009 Aug;15(4):634-40. Epub 2009 Jun 10.

Kehoe SM, Zivanovic O, Ferguson SE, Barakat RR, Soslow RA. Clinicopathologic features of bone metastases and outcomes in patients with primary endometrial cancer. Gynecol Oncol 2010 May;117(2):229-33. Epub 2010 Mar 2

Kim IR, Murakami K, Chen NJ, Saibil SD, Matysiak-Zablocki E, Elford AR, Bonnard M, Benchimol S, Jurisicova A, Yeh WC, Ohashi PS. DNA damage- and stress-induced apoptosis occurs independently of PIDD. Apoptosis 2009 Sep;14(9):1039-49.

Király MA, Campbell J, Park E, Bates HE, Yue JT, Rao V, Matthews SG, Bikopoulos G, Rozakis- Adcock M, Giacca A, Vranic M, Riddell MC. Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats. Am J Physiol Endocrinol Metab 2010 Mar;298(3):E671-82. Epub 2009 Dec 8.

Kirby JM, Kachura JR, Rajan DK, Sniderman KW, Simons ME, Windrim RC, Kingdom JC. Arterial embolization for primary postpartum hemorrhage. J Vasc Interv Radiol 2009 Aug;20(8):1036-45.

Klieger-Grossmann C, Djokanovic N, Chitayat D, Koren G. In utero exposure to therapeutic radiation for Hodgkin lymphoma. Can Fam Physician 2009 Oct;55(10):988-91.

50 PUBLICATIONS 2009-2010

Knight BS, Sunn N, Pennell CE, Adamson SL, Lye SJ. Developmental regulation of cardiovascular function is dependent on both genotype and environment. Am J Physiol Heart Circ Physiol 2009 Dec;297(6):H2234-41. Epub 2009 Sep 25.

Koifman A, Feigenbaum A, Bi W, Shaffer LG, Rosenfeld J, Blaser S, Chitayat D. A homozygous deletion of 8q24.3 including the NIBP gene associated with severe developmental delay, dysgenesis of the corpus callosum, and dysmorphic facial features. Am J Med Genet A 2010 May;152A(5):1268-72.

Koifman A, Shannon P, Kingdom J, Chitayat D. Diaphragmatic hernia and limb abnormalities syndrome (Froster syndrome). Clinical Dysmorphology 18(3):151-3, 2009 Jul.

Kollara A, Brown TJ. Four and a half LIM domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity. J Steroid Biochem Mol Biol 2010 Jan;118(1-2):51-8. Epub 2009 Oct 6.

Kotsopoulos J, Chen Z, Vallis KA, Poll A, Ghadirian P, Kennedy G, Ainsworth P, Narod SA. Toenail selenium status and DNA repair capacity among female BRCA1 mutation carriers. Cancer Causes Control 2010 May;21(5):679-87. Epub 2010 Jan 9.

Kroft J, Aneja A, Tyrwhitt J, Ternamian A. Laparoscopic peritoneal entry preferences among Canadian gynaecologists. J Obstet Gynaecol Can 2009 Jul;31(7):641-8.

Labrie V, Fukumura R, Rastogi A, Fick LJ, Wang W, Boutros PC, Kennedy JL, Semeralul MO, Lee FH, Baker GB, Belsham DD, Barger SW, Gondo Y, Wong AH, Roder JC. Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet 2009 Sep 1;18(17):3227- 43. Epub 2009 May 30.

Lawrentschuk N, Haider MA, Daljeet N, Evans A, Toi A, Finelli A, Trachtenberg J, Zlotta A, Fleshner N. 'Prostatic evasive anterior tumours': The role of magnetic resonance imaging. BJU Int 2010 May;105(9):1231-6. Epub 2009 Oct 8.

Lawrentschuk N, Lockwood G, Davies P, Evans A, Sweet J, Toi A, Fleshner NE. Predicting prostate biopsy outcome: Artificial neural networks and polychotomous regression are equivalent models. Int Urol Nephrol 2010 May 13. [Epub ahead of print]

Lawrentschuk N, Toi A, Lockwood GA, Evans A, Finelli A, O'Malley M, Margolis M, Ghai S, Fleshner NE. Operator is an independent predictor of detecting prostate cancer at transrectal ultrasound guided prostate biopsy. J Urol 2009 Dec;182(6):2659-63.

Lee Y, Balki M, Parkes R, Carvalho JC. Dose requirement of intrathecal bupivacaine for cesarean delivery is similar in obese and normal weight women. Rev Bras Anestesiol 2009 Nov-Dec;59(6):674-83.

Lehman AM, Eydoux P, Doherty D, Glass IA, Chitayat D, Chung BY, Langlois S, Yong SL, Lowry RB, Hildebrandt F, Trnka P. Co-occurrence of Joubert syndrome and Jeune asphyxiating thoracic dystrophy. Am J Med Genet A 2010 Jun;152A(6):1411-9.

Levenback CF, van der Zee AG, Rob L, Plante M, Covens A, Schneider A, Coleman R, Solima E, Hertel H, Barranger E, Obermair A, Roy M. Sentinel lymph node biopsy in patients with gynecologic cancers Expert panel statement from the International Sentinel Node Society Meeting, February 21, 2008. Gynecol Oncol 2009 Aug;114(2):151-6. 51 PUBLICATIONS 2009-2010

Lightner D, Rovner E, Corcos J, Payne C, Brubaker L, Drutz H, Steinhoff G; Zuidex Study Group. Randomized controlled multisite trial of injected bulking agents for women with intrinsic sphincter deficiency: mid-urethral injection of Zuidex via the Implacer versus proximal urethral injection of Contigen cystoscopically. Urology 2009 Oct;74(4):771-5. Epub 2009 Aug 5.

Liu X, Fernandes R, Jurisicova A, Casper RF, Sun Y. In situ mechanical characterization of mouse oocytes using a cell holding device. Lab Chip 2010 Jun 14. [Epub ahead of print]

Loutfy MR, Hart TA, Mohammed SS, Su D, Ralph ED, Walmsley SL, Soje LC, Muchenje M, Rachlis AR, Smaill FM, Angel JB, Raboud JM, Silverman MS, Tharao WE, Gough K, Yudin MH; Ontario HIV Fertility Research Team. Fertility desires and intentions of HIV-positive women of reproductive age in Ontario, Canada: a cross-sectional study. PLoS One 2009 Dec 7;4(12):e7925.

Mackay HJ, Gallinger S, Tsao MS, McLachlin CM, Tu D, Keiser K, Eisenhauer EA, Oza AM. Prognostic value of microsatellite instability (MSI) and PTEN expression in women with endometrial cancer: Results from studies of the NCIC Clinical Trials Group (NCIC CTG). Eur J Cancer 2010 May;46(8):1365-73. Epub 2010 Mar 19.

Mackay HJ, Hirte H, Colgan T, Covens A, MacAlpine K, Grenci P, Wang L, Mason J, Pham PA, Tsao MS, Pan J, Zwiebel J, Oza AM. Phase II trial of the histone deacetylase inhibitor belinostat in women with platinum resistant epithelial ovarian cancer and micropapillary (LMP) ovarian tumours. Eur J Cancer 2010 Jun;46(9):1573-9. Epub 2010 Mar 19.

Mackay HJ, Tinker A, Winquist E, Thomas G, Swenerton K, Oza A, Sederias J, Ivy P, Eisenhauer EA. A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184. Gynecol Oncol 2010 Feb;116(2):163-7. Epub 2009 Sep 8.

MacRae AR, Chodirker BN, Davies GA, Palomaki GE, Knight GJ, Minett J, Kavsak PA, Toi A, Chitayat D, Van Caeseele PG. Second and first trimester estimation of risk for Down syndrome: implementation and performance in the SAFER study. Prenat Diagn 2010 May;30(5):459-66.

Mai S, Wei K, Flenniken A, Adamson SL, Rossant J, Aubin JE, Gong SG. The missense mutation W290R in Fgfr2 causes developmental defects from aberrant IIIb and IIIc signaling. Dev Dyn 2010 Jun;239(6):1888-900.

Margarido CB, Arzola C, Balki M, Carvalho JC. Anesthesiologists' learning curves for ultrasound assessment of the lumbar spine. Can J Anaesth 2010 Feb;57(2):120-6. Epub 2009 Dec 30.

Martin AM, Berger H, Nisenbaum R, Lausman AY, MacGarvie S, Crerar C, Ray JG. Abdominal visceral adiposity in the first trimester predicts glucose intolerance in later pregnancy. Diabetes Care 2009 Jul;32(7):1308-10. Epub 2009 Apr 23.

May T, Virtanen C, Sharma M, Milea A, Begley H, Rosen B, Murphy KJ, Brown TJ, Shaw PA. Low malignant potential tumors with micropapillary features are molecularly similar to low-grade serous carcinoma of the ovary. Gynecol Oncol 2010 Apr;117(1):9-17. Epub 2010 Feb 1.

Mayer CM, Belsham DD. Central insulin signaling is attenuated by long-term insulin exposure via insulin receptor substrate-1 serine phosphorylation, proteasomal degradation, and lysosomal insulin receptor degradation. Endocrinology 2010 Jan;151(1):75-84. Epub 2009 Nov 3.

52 PUBLICATIONS 2009-2010

Mayer CM, Belsham DD. Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons. Mol Cell Endocrinol 2009 Aug 13;307(1-2):99-108. Epub 2009 Mar 14.

Mayer CM, Belsham DD. Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation. Endocrinology 2010 Feb;151(2):576-85. Epub 2009 Dec 1.

Mir A, Kaufman L, Noor A, Motazacker MM, Jamil T, Azam M, Kahrizi K, Rafiq MA, Weksberg R, Nasr T, Naeem F, Tzschach A, Kuss AW, Ishak GE, Doherty D, Ropers HH, Barkovich AJ, Najmabadi H, Ayub M, Vincent JB. Identification of mutations in TRAPPC9, which encodes the NIK- and IKK- beta-binding protein, in nonsyndromic autosomal-recessive mental retardation. Am J Hum Genet 2009 Dec;85(6):909-15.

Moore AR, Siddiqui N, Kassel EE, Carvalho JC. Unintentional subdural catheter placement during labor analgesia shows typical radiological pattern but atypical response to the Tsui test. Int J Obstet Anesth 2010 Jan;19(1):111-4. Epub 2009 Nov 28.

Mousa NA, Casper RF. Menopausal estrogen deprivation activates steroid sensitive stem cells (3SC) and local estrogen biosynthesis: A model for breast cancer development. Bioscience Hypotheses 2009;2(4):252-6.

Mousa NA, Jebrail MJ, Yang H, Abdelgawad M, Metalnikov P, Chen J, Wheeler AR, Casper RF. Droplet-scale estrogen assays in breast tissue, blood, and serum. Sci Transl Med 2009 Oct 7;1(1):1ra2.

Murphy KE, Hannah ME, Willan AR, Hewson SA, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA, MACS Collaborative Group Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet 372(9656):2143-51, 2009 Dec 20

Neuhausen SL, Brummel S, Ding YC, Singer CF, Pfeiler G, Lynch HT, Nathanson KL, Rebbeck TR, Garber JE, Couch F, Weitzel J, Narod SA, Ganz PA, Daly MB, Godwin AK, Isaacs C, Olopade OI, Tomlinson G, Rubinstein WS, Tung N, Blum JL, Gillen DL. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers. Breast Cancer Res 2009;11(5):R76. Epub .

Nofech-Mozes S, Hanna WM, Cil T, Quan ML, Holloway C, Khalifa MA. Intraoperative consultation for axillary sentinel lymph node biopsy: An 8-year audit. Int J Surg Pathol 2010 Apr;18(2):129-37. Epub 2009 Feb 17.

Nofech-Mozes S, Khalifa M, Ismiil N, Dubé V, Saad RS, Sun P, Seth A, Ghorab Z. Detection of HPV-DNA by a PCR-based method in formalin-fixed, paraffin-embedded tissue from rare endocervical carcinoma types. Appl Immunohistochem Mol Morphol 2010 Jan;18(1):80-5.

Nomura-Kitabayashi A, Anderson GA, Sleep G, Mena J, Karabegovic A, Karamath S, Letarte M, Puri MC. Endoglin is dispensable for angiogenesis, but required for endocardial cushion formation in the midgestation mouse embryo. Dev Biol 2009 Nov 1;335(1):66-77. Epub 2009 Aug 21.

Norman G, Neville A, Blake JM, Mueller B. Assessment steers learning down the right road: impact of progress testing on licensing examination performance. Med Teach 2010;32(6):496-9. 53 PUBLICATIONS 2009-2010

Nulman I, Sgro M, Barrera M, Chitayat D, Cairney J, Koren G. Long-term neurodevelopment of children exposed in utero to ciclosporin after maternal renal transplant. Paediatr Drugs 2010 Apr 1;12(2):113-22. doi: 10.2165/11316280-000000000-00000.

Osborne LR. Animal models of Williams syndrome. Am J Med Genet C Semin Med Genet 2010 May 15;154C(2):209-19.

Osborne LR. Caveat mTOR: Aberrant signaling disrupts corticogenesis. J Clin Invest 2010 May 3;120(5):1392-5. doi: 10.1172/JCI43030. Epub 2010 Apr 26.

Parr G, Leyland N. The hockey stick sign in appendiceal endometriosis. J Obstet Gynaecol Can 2010 May;32(5):421, 422. English, French.

Perumalsamy A, Fernandes R, Lai I, Detmar J, Varmuza S, Casper RF, Jurisicova A. Developmental consequences of alternative Bcl-x splicing during preimplantation embryo development. FEBS J 2010 Mar;277(5):1219-33. Epub 2010 Feb 3.

Pober BR, Wang E, Caprio S, Petersen KF, Brandt C, Stanley T, Osborne LR, Dzuria J, Gulanski B.High prevalence of diabetes and pre-diabetes in adults with Williams syndrome. Am J Med Genet C Semin Med Genet 2010 May 15;154C(2):291-8.

Poynter B, Shuman M, Diaz-Granados N, Kapral M, Grace SL, Stewart DE. Sex differences in the prevalence of post-stroke depression: a systematic review. Psychosomatics 2009 Nov-Dec;50(6):563-9.

Prisant N, Tubiana R, Lefebvre G, Lebray P, Marcelin AG, Thibault V, Rosenblum O, Bonmarchand M, Vauthier-Brouzes D, Golmard JL, Katlama C, Poirot C. HIV-1 or hepatitis C chronic infection in serodiscordant infertile couples has no impact on infertility treatment outcome. Fertil Steril. 2010 Feb;93(3):1020-3. Epub 2009 Sep 3.

Proctor LK, Rushworth V, Shah PS, Keunen J, Windrim R, Ryan G, Kingdom J. Incorporation of femur length leads to underestimation of fetal weight in asymmetric preterm growth restriction. Ultrasound Obstet Gynecol 2010 Apr;35(4):442-8.

Proctor LK, Toal M, Keating S, Chitayat D, Okun N, Windrim RC, Smith GC, Kingdom JC. Placental size and the prediction of severe early-onset intrauterine growth restriction in women with low pregnancy-associated plasma protein-A. Ultrasound Obstet Gynecol 2009 Sep;34(3):274-82.

Proulx E, Young EJ, Osborne LR, Lambe EK. Enhanced prefrontal serotonin 5-HT(1A) currents in a mouse model of Williams-Beuren syndrome with low innate anxiety. J Neurodev Disord 2010 Jun;2(2):99-108. Epub 2010 Mar 19.

Ray JE, Garcia J, Jurisicova A, Caniggia I. Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia. Cell Death Differ 2010 May;17(5):846-59. Epub 2009 Nov 27.

Retnakaran R, Qi Y, Connelly PW, Sermer M, Hanley AJ, Zinman B. Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia. Diabetologia 2010 Feb;53(2):268-76. Epub 2009 Nov 24.

54 PUBLICATIONS 2009-2010

Retnakaran R, Qi Y, Connelly PW, Sermer M, Hanley AJ, Zinman B. Risk of early progression to prediabetes or diabetes in women with recent gestational dysglycemia but normal glucose tolerance at 3- months postpartum. Clin Endocrinol (Oxf) 2010 Jun 9. [Epub ahead of print]

Retnakaran R, Qi Y, Sermer M, Connelly PW, Zinman B, Hanley AJ. Comparison of National Diabetes Data Group and American Diabetes Association diagnostic criteria for gestational diabetes in their identification of postpartum risk of glucose intolerance. Diabetes Res Clin Pract 2009 Jul;85(1):40-6. Epub 2009 May 7.

Robertson D, Lefebvre G, Leyland N, Wolfman W, Allaire C, Awadalla A, Best C, Contestabile E, Dunn S, Heywood M, Leroux N, Potestio F, Rittenberg D, Senikas V, Soucy R, Singh S. Adhesion prevention in gynaecological surgery. J Obstet Gynaecol Can 2010 Jun;32(6):598-602.

Rugg-Gunn PJ, Cox BJ, Ralston A, Rossant J. Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10783-90. Epub 2010 May 17.

Saad RS, Ismiil N, Dubé V, Nofech-Mozes S, Khalifa MA. CDX-2 expression is a common event in primary intestinal-type endocervical adenocarcinoma.Am J Clin Pathol 2009 Oct; 132(4):531-8.

Sacher J, Wilson AA, Houle S, Rusjan P, Hassan S, Bloomfield PM, Stewart DE, Meyer JH. Elevated brain monoamine oxidase A binding in the early postpartum period. Arch Gen Psychiatry 2010 May;67(5):468-74.

Savasi I, Lacy JA, Gerstle JT, Stephens D, Kives S, Allen L. Management of ovarian dermoid cysts in the pediatric and adolescent population. J Pediatr Adolesc Gynecol 2009 Dec;22(6):360-4. Epub 2009 Jul 8.

Shynlova O, Chow M, Lye SJ. Expression and organization of basement membranes and focal adhesion proteins in pregnant myometrium is regulated by uterine stretch. Reprod Sci 2009 Oct;16(10):960-9. Epub 2009 Jul 14.

Shynlova O, Dorogin A, Lye SJ. Stretch-induced uterine myocyte differentiation during rat pregnancy: Involvement of caspase activation. Biol Reprod 2010 Jun;82(6):1248-55. Epub 2010 Feb 24.

Shynlova O, Kwong R, Lye SJ. Mechanical stretch regulates hypertrophic phenotype of the myometrium during pregnancy. Reproduction 2010 Jan;139(1):247-53. Epub .

Skeete D, Riddell R, Wolfman W, Colgan TJ. Massive lymphocytic infiltration in a uterine leiomyoma post-gonadotrophin-releasing hormone agonist therapy. Can Journ Pathol 2009; 1(3):18-21.

Stewart DE, Dorado LM, Diaz-Granados N, Rondon M, Saavedra J, Posada-Villa J, Torres Y. Examining gender equity in health policies in a low- (Peru), middle- (Colombia), and high- (Canada) income country in the Americas. J Public Health Policy 2009 Dec;30(4):439-54.

Suchy J, Cybulski C, Wokołorczyk D, Oszurek O, Górski B, Debniak T, Jakubowska A, Gronwald J, Huzarski T, Byrski T, Dziuba I, Gogacz M, Wiśniowski R, Wandzel P, Banaszkiewicz Z, Kurzawski G, Kładny J, Narod SA, Lubiński J. CHEK2 mutations and HNPCC-related colorectal cancer. Int J Cancer 2010 Jun 15;126(12):3005-9.

55 PUBLICATIONS 2009-2010

Sun LM, Walker MC, Cao HL, Yang Q, Duan T, Kingdom JC. Assisted reproductive technology and placenta-mediated adverse pregnancy outcomes. Obstet Gynecol 2009 Oct;114(4):818-24.

Ten Bokkel Huinink WW, Sufliarsky J, Smit WM, Spanik S, Wagnerova M, Hirte HW, Kaye S, Johri AR, Oza AM. Safety and efficacy of patupilone in patients with advanced ovarian, primary fallopian, or primary peritoneal cancer: a phase I, open-label, dose-escalation study. J Clin Oncol 2009 Jul 1;27(19):3097-103. Epub 2009 May 18.

Tierney MC, Oh P, Moineddin R, Greenblatt EM, Snow WG, Fisher RH, Iazzetta J, Hyslop PS, MacLusky NJ. A randomized double-blind trial of the effects of hormone therapy on delayed verbal recall in older women. Psychoneuroendocrinology 2009 Aug;34(7):1065-74. Epub 2009 Mar 17.

Toporsian M, Jerkic M, Zhou YQ, Kabir MG, Yu LX, McIntyre BA, Davis A, Wang YJ, Stewart DJ, Belik J, Husain M, Henkelman M, Letarte M. Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia. Arterioscler Thromb Vasc Biol 2010 Mar;30(3):509-17. Epub 2009 Dec 30. Unlugedik E, Alfaidy N, Holloway A, Lye S, Bocking A, Challis J, Gibb W. Expression and regulation of prostaglandin receptors in the human placenta and fetal membranes at term and preterm. Reprod Fertil Dev 2010;22(5):796-807.

Uxa R, Baczyk D, Kingdom JC, Viero S, Casper R, Keating S. Genetic polymorphisms in the fibrinolytic system of placentas with massive perivillous fibrin deposition. Placenta 2010 Jun;31(6):499- 505. Epub 2010 May 5.

Vardhana [Sharma] PA, Julius MA, Pollak SV, Lustbader EG, Trousdale RK, Lustbader JW. A unique human chorionic gonadotropin antagonist suppresses ovarian hyperstimulation syndrome in rats. Endocrinology 2009 Aug;150(8):3807-14. Epub 2009 May 14.

Vause TD, Cheung AP, Sierra S, Claman P, Graham J, Guillemin JA, Lapensée L, Steward S, Wong BC; Society of Obstetricians and Gynecologists of Canada. Ovulation induction in polycystic ovary syndrome. J Obstet Gynaecol Can 2010 May;32(5):495-502.

Vicus D, Beiner ME, Klachook S, Le LW, Laframboise S, Mackay H. Pure dysgerminoma of the ovary 35 years on: A single institutional experience. Gynecol Oncol 2010 Apr;117(1):23-6. Epub 2010 Jan 25.

Vicus D, Finch A, Cass I, Rosen B, Murphy J, Fan I, Royer R, McLaughlin J, Karlan B, Narod SA. Prevalence of BRCA1 and BRCA2 germ line mutations among women with carcinoma of the fallopian tube. Gynecol Oncol 2010 Jun 4. [Epub ahead of print]

Vicus D, Rosen B, Lubinski J, Domchek S, Kauff ND, Lynch HT, Isaacs C, Tung N, Sun P, Narod SA; Hereditary Ovarian Cancer Clinical Study Group.Tamoxifen and the risk of ovarian cancer in BRCA1 mutation carriers. Gynecol Oncol 2009 Oct;115(1):135-7. Epub 2009 Jul 3.

Vohra S, Akoury H, Bernstein P, Einarson TR, Pairaudeau N, Taddio A, Koren G. The effectiveness of Proctofoam-HC for treatment of hemorrhoids in late pregnancy. J Obstet Gynaecol Can 2009 Jul;31(7):654-9.

Wan AW, Jevremovic A, Selamet Tierney ES, McCrindle BW, Dunn E, Manlhiot C, Wald RM, Kingdom JP, Jaeggi ET, Nield LE. Comparison of impact of prenatal versus postnatal diagnosis of congenitally corrected transposition of the great arteries. Am J Cardiol 2009 Nov 1;104(9):1276-9.

56 PUBLICATIONS 2009-2010

Wang Y, Belsham DD, Glogauer M. 4.Rac1 and Rac2 in osteoclastogenesis: A cell immortalization model. Calcif Tissue Int 2009 Sep;85(3):257-66. Epub 2009 Aug 2.

Warwick J, Vardaki E, Fattizzi N, McNeish I, Jeyarajah A, Oram D, Hassan L, Covens A, Duffy S, Reynolds K. Defining the surgical management of suspected early-stage ovarian cancer by estimating patient numbers through alternative management strategies. BJOG 2009 Aug;116(9):1225-41. Epub 2009 May 28.

Whittle WL, Singh SS, Allen L, Glaude L, Thomas J, Windrim R, Leyland N. Laparoscopic cervico- isthmic cerclage: Surgical technique and obstetric outcomes. Am J Obstet Gynecol 2009 Oct;201(4):364.e1-7.

Widdows K, Kingdom JC, Ansari T. Double immuno-labelling of proliferating villous cytotrophoblasts in thick paraffin sections: integrating immuno-histochemistry and stereology in the human placenta. Placenta 2009 Aug;30(8):735-8. Epub 2009 Jun 12.

Williams SJ, Shynlova O, Lye SJ, MacPhee DJ. Spatiotemporal expression of alpha(1), alpha(3) and beta(1) integrin subunits is altered in rat myometrium during pregnancy and labour. Reprod Fertil Dev 2010;22(4):718-32.

Wolf N, Yang W, Dunk CE, Gashaw I, Lye SJ, Ring T, Schmidt M, Winterhager E, Gellhaus A. Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor- 1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast. Endocrinology 2010 Jun;151(6):2835-45. Epub 2010 Mar 17.

Wong CJ, Casper RF, Rogers IM. Epigenetic changes to human umbilical cord blood cells cultured with three proteins indicate partial reprogramming to a pluripotent state. Exp Cell Res 2010 Apr 1;316(6):927- 39. Epub 2010 Jan 22.

Xu H, Perez-Cuevas R, Xiong X, Reyes H, Roy C, Julien P, Smith G, von Dadelszen P, Leduc L, Audibert F, Moutquin JM, Piedboeuf B, Shatenstein B, Parra-Cabrera S, Choquette P, Winsor S, Wood S, Benjamin A, Walker M, Helewa M, Dubé J, Tawagi G, Seaward G, Ohlsson A, Magee LA, Olatunbosun F, Gratton R, Shear R, Demianczuk N, Collet JP, Wei S, Fraser WD; INTAPP study group. An international trial of antioxidants in the prevention of preeclampsia (INTAPP). Am J Obstet Gynecol 2010 Mar;202(3):239.e1-239.e10.

Yamanaka N, Wong CJ, Gertsenstein M, Casper RF, Nagy A, Rogers IM. Bone marrow transplantation results in human donor blood cells acquiring and displaying mouse recipient class I MHC and CD45 antigens on their surface. PLoS One 2009 Dec 31;4(12):e8489.

Yinon Y, Kingdom JC, Proctor LK, Kelly EN, Salle JL, Wherrett D, Keating S, Nevo O, Chitayat D. Hypospadias in males with intrauterine growth restriction due to placental insufficiency: the placental role in the embryogenesis of male external genitalia. Am J Med Genet A 2010 Jan;152A(1):75-83.

Yinon Y, Siu SC, Warshafsky C, Maxwell C, McLeod A, Colman JM, Sermer M, Silversides CK. Use of low molecular weight heparin in pregnant women with mechanical heart valves. Am J Cardiol 2009 Nov 1;104(9):1259-63. Epub 2009 Sep 16.

You B, Brade A, Magalhaes JM, Siu LL, Oza A, Lovell S, Wang L, Hedley DW, Nicacio LV, Chen EX. A dose-escalation phase I trial of nimotuzumab, an antibody against the epidermal growth factor receptor, in patients with advanced solid malignancies. Invest New Drugs 2010 May 8. Epub ahead of print 57 PUBLICATIONS 2009-2010

Yudin MH, Salripour M, Sgro MD. Impact of patient education on knowledge of influenza and vaccine recommendations among pregnant women.J Obstet Gynaecol Can 2010 Mar;32(3):232-7.

Yudin MH, Shapiro HM, Loutfy MR. Access to infertility services in Canada for HIV-positive individuals and couples: A cross-sectional study. Reprod Health 2010 May 12;7:7.

Zhang K, Li L, Huang C, Shen C, Tan F, Xia C, Liu P, Rossant J, Jing N. Distinct functions of BMP4 during different stages of mouse ES cell neural commitment. Development. 2010 Jul;137(13):2095-105. Epub 2010 May 26. 58 PUBLICATIONS 2009-2010

Invited Papers, Case Reports, Commentaries, Editorials, Reviews and Book Chapters

Allen L. Opinion one: A case for delayed gonadectomy. J Pediatr Adolesc Gynecol 2009 Dec;22(6):381- 4.

Barnett C, Langer JC, Hinek A, Bradley TJ, Chitayat D. Looking past the lump: genetic aspects of inguinal hernia in children. J Pediatr Surg 2009 Jul;44(7):1423-31. Review

Barnett CP, Jaeggi E, Han RK, Nevo O, Keating S, Shannon P, Bitnun A, Chitayat D. Unusual cardiac presentation of congenital cytomegalovirus infection. Ultrasound Obstet Gynecol 2010 Jan;35(1):119-20.

Bentov Y, Casper RF. Testosterone-induced downregulation of anti-Müllerian hormone expression in granulosa cells from small bovine follicles. Faculty of 1000 Medicine September 2009, Review.

Bentov Y, Casper RF. The safety of metoclopramide use in the first trimester of pregnancy. Faculty of 1000 Medicine July 2009, Review.

Bentov Y, Esfandiari N, Gokturk A, Burstein E, Fainaru O, Casper RF. An ongoing pregnancy from two waves of follicles developing during a long follicular phase of the same cycle. Fertil Steril 2010 Jun;94(1):350.e8-11.

Berger H, Sermer M. Counterpoint: Selective screening for gestational diabetes mellitus. Diabetes Care 2009 Jul; 32(7):1352-4.

Chamberlain S, Bocking A, McGrath M, Faught W, Liston R, Wilson RD, Morris M, Sagle P, Armson A, O'Grady T, Richardson B. Teaching pelvic examinations under anaesthesia: what do women think? J Obstet Gynaecol Can 2010 Jun;32(6):539-40.

Chung HY, Uster-Friedberg T, Pentaz S, Blaser S, Murphy K, Chitayat D. Fetal parietal foramina: Ultrasound and MRI findings. Ultrasound Obstet Gynecol 2010 Jun 28. Epub ahead of print

Colgan TJ, McLachlin M. Endometrial Lesions, Unusual Tumors, and Extrauterine Cancer. In: Comprehensive Cytopathology, 3rd ed. Philadelphia: Saunders Elsevier, 2008; Chapter 10:247-71.

Corbett SL, Walsh CM, Spitzer RF, Ngan BY, Kives S, Zachos M. Vulvar inflammation as the only clinical manifestation of Crohn disease in an 8-year-old girl. Pediatrics 2010 Jun; 125(6):e1518-22. Epub 2010 May 10.

Derzko C. Bioidentical Hormone Therapy (Snell Rounds) Endocrinology Rounds. @ www.endocrinologyrounds.ca, University of Toronto Department of Medicine, Endocrinology Division, St. Michael’s Hospital. 2009;9(5):1-6.

Derzko C. I Am Unique (A Menopause Handbook for Patients ). A SIGMA project, 2009.

Derzko C. Menopause Myths (An Information Booklet for Patients). A SIGMA project, 2010.

59 PUBLICATIONS 2009-2010

Detmar J, Jurisicova A.Embryonic resorption and polycyclic aromatic hydrocarbons: putative immune- mediated mechanisms. Syst Biol Reprod Med 2010 Feb;56(1):3-17. Review.

Dodd JM, McLeod A, Windrim RC, Kingdom J. Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction. Cochrane Database Syst Rev 2010 Jun 16;6:CD006780.

Dodd JM, Windrim RC, van Kamp IL. Techniques of intrauterine fetal transfusion for women with red- cell isoimmunisation for improving health outcomes. Cochrane Database Syst Rev 2010 Jun 16;6:CD007096. Review.Freathy RM, Mook-Kanamori DO, Sovio U, …, Pennell CE, et al.Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet 2010 May;42(5):430-5. Epub 2010 Apr 6.

Drutz HP. Axel Ingelman-Sundberg (1910–2009): IUGA loses a founding father. Int Urogynecol J 2010;21(3):259-60.

Easton WA. Overactive bladder symptoms in women: current concepts in patient management.Can J Urol 2010 Feb;17 Suppl 1:12-7. Review.

Elit L, Fyles AW, Devries MC, Oliver TK, Fung-Kee-Fung M; Gynecology Cancer Disease Site Group (Covens A, Dodge J, Oza A). Follow-up for women after treatment for cervical cancer: A systematic review. Gynecol Oncol 2009 Sep;114(3):528-35. Epub 2009 Jun 26. Review.

Esfandiari N, Kapoor M, Burjaq H, Chang P, Gotlieb L, Casper RF. Monozygotic twins in infertile patients with advanced maternal age: Case reports and review of the literature. Fertil Steril 2009 Sep;92(3):1168.e9-1168.e12. Epub 2009 Jul 15. Review.

Esfandiari N, Nazemian Z, Casper RF. Three-dimensional culture of endometrial cells: An in vitro model of endometriosis. Am J Reprod Immunol 2008 Oct;60(4):283-9. Review.

Farrugia M, Thomas J, Bernstein P. Canada’s Pregnancy Care Book. Toronto: Robert Rose Inc., September 2009.

Fung-Kee-Fung M, Howlett RI, Oliver TK, Murphy J, Elit L, Strychowsky J, Roth N, Bryson SC, McLachlin CM, Bertrand M, Shier M, McMahon E, McFaul S. The optimum organization for the delivery of colposcopy service in Ontario: A systematic review. J Low Genit Tract Dis 2010 Jan;14(1):11-21. Review.

Gagnon R, Morin L, Bly S, Butt K, Cargill YM, Denis N, Hietala-Coyle MA, Lim KI, Ouellet A, Raciot MH, Salem S; Diagnostic Imaging Committee, Hudon L, Basso M, Bos H, Delisle MF, Farine D, Grabowska K, Menticoglou S, Mundle W, Murphy-Kaulbeck L, Pressey T, Roggensack A; Maternal Fetal Medicine Committee. Guidelines for the management of vasa previa. J Obstet Gynaecol Can 2009 Aug;31(8):748-60. Review.

Gagnon R, Morin L, Bly S, Butt K, Cargil YM, Denis N, Hietala-Coyle MA, Lim KI, Ouellet A, Racicot MH, Salem S, Hudon L, Basso M, Bos H, Delisle MF, Farine D, Grabowska K, Menticoglou S, Mundle W, Murphy-Kaulbeck L, Ouellet A, Pressey T, Roggensack A; Diagnostic Imaging Committee; Maternal Fetal Medicine Committee. SOGC CLINICAL PRACTICE GUIDELINE: Guidelines for the management of vasa previa. Int J Gynaecol Obstet 2010 Jan;108(1):85-9.

60 PUBLICATIONS 2009-2010

Gien LT, Beauchemin MC, Thomas G. Adenocarcinoma: A unique cervical cancer. Gynecol Oncol 2010 Jan;116(1):140-6. Epub 2009 Oct 31. Review.

Gien LT, Covens A. Fertility-sparing options for early stage cervical cancer. Gynecol Oncol 2010 May;117(2):350-7. Epub 2010 Feb 16. Review.

Gien LT, Covens A. Total mesometrial resection for cancer of the cervix: The future surgical procedure, or oblivion? Lancet Oncol 2009 Jul;10(7):644-5.

Gouin K, Kingdom J, Keating S. A giant cord hemangioma diagnosed at 32 weeks' gestation. J Obstet Gynaecol Can. 2009 Aug;31(8):695-6.

Gruslin A, Steben M, Halperin S, Money DM, Yudin MH; Infectious Diseases Committee of the Society of Obstetricians and Gynaecologists of Canada. Immunization in pregnancy. J Obstet Gynaecol Can. 2009 Nov;31(11):1085-101.

Hamoudi A, Shier M. Late complications of childhood female genital mutilation. J Obstet Gynaecol Can 2010 Jun;32(6):587-9.

Hauspy J, Jiménez W, Rosen B, Gotlieb WH, Fung-Kee-Fung M, Plante M. Laparoscopic surgery for endometrial cancer: A review. J Obstet Gynaecol Can 2010 Jun;32(6):570-9.

Herer E, Canadian editor. Pregnancy Day By Day Canadian Edition (Hardcover) Toronto: Dorling Kindersley Ltd, 2009.

Hladunewich MA, Steinberg G, Karumanchi SA, Levine RJ, Keating S, Kingdom J, Keunen J. Angiogenic factor abnormalities and fetal demise in a twin pregnancy. Nat Rev Nephrol 2009 Nov;5(11):658-62. Review.

Jaeggi ET, Chitayat D, Taylor G. Atrial standstill associated with loss of atrial myocytes: A rare cause of fetal bradyarrhythmia. Heart Rhythm 2009 Sep;6(9):1370-2. Epub 2009 May 4.

Javed M, Esfandiari N, Casper RF. Failed fertilization after clinical intracytoplasmic sperm injection. Reprod Biomed Online 2010 Jan;20(1):56-67. Epub 2009 Oct 30. Review.

Jaworsky D, Thompson C, Yudin MH, Bitnun A, Brophy J, Samson L, Antoniou T, Loutfy MR. Use of newer antiretroviral agents, darunavir and etravirine with or without raltegravir, in pregnancy: a report of two cases. Antivir Ther 2010;15(4):677-80.

Jhaveri KS, Mazrani W, Chawla TP, Filobbos R, Toi A, Jarvi K. The role of cross-sectional imaging in male infertility: A pictorial review. Can Assoc Radiol J 2010 Jun;61(3):144-55. Epub 2010 Feb 26. Review.

Johnson J, Stewart DE. DSM-V: toward a gender sensitive approach to psychiatric diagnosis. Arch Womens Ment Health 2010 Feb;13(1):17-9. Review.

Junqueira BL, Allen LM, Spitzer RF, Lucco KL, Babyn PS, Doria AS. Müllerian duct anomalies and mimics in children and adolescents: Correlative intraoperative assessment with clinical imaging. Radiographics 2009 Jul-Aug;29(4):1085-103. Review.

61 PUBLICATIONS 2009-2010

Kives S, Lefebvre G, Wolfman W, Leyland N, Allaire C, Awadalla A, Best C, Leroux N, Potestio F, Rittenberg D, Soucy R, Singh S. SOGC Clinical Practice Guidelines. Supracervical hysterectomy. J Obstet Gynaecol Can 2010 Jan;32(1):62-8.

Klieger-Grossmann C, Djokanovic N, Chitayat D, Koren G. In utero exposure to therapeutic radiation for Hodgkin lymphoma. Can Fam Physician 2009 Oct;55(10):988-91.

Kroft J, Kung RC. Postoperative pubic symphysis osteomyelitis after laparoscopic two-team sling with anterior and posterior colporrhaphy. J Minim Invasive Gynecol 2009 Jul-Aug;16(4):513-5.

Kroft J, Sabra S, Arthur R, Wolfman W. Unexplained amenorrhea in a patient taking methotrexate for the treatment of rheumatoid arthritis. Gynecol Endocrinol 2010 Mar;26(3):179-80.

Le T, Giede C, Salem S, Lefebvre G, Rosen B, Bentley J, Kupets R, Power P, Renaud MC, Bryson P, Davis DB, Lau S, Lotocki R, Senikas V, Morin L, Bly S, Butt K, Cargill YM, Denis N, Gagnon R, Hietala-Coyle MA, Lim KI, Ouellet A, Raciot MH; Society of Obstetricians and Gynaecologists of Canada. Initial evaluation and referral guidelines for management of pelvic/ovarian masses. J Obstet Gynaecol Can 2009 Jul;31(7):668-80.

Leblanc GG, Golanov E, Awad IA, Young WL; Biology of Vascular Malformations of the Brain NINDS Workshop Collaborators [Letarte M]. Biology of vascular malformations of the brain. Stroke 2009 Dec;40(12):e694-702. Epub 2009 Oct 15. Review.

Lyons E. In: Farrugia M, Thomas J, Bernstein P, eds. Canada’s Pregnancy Care Book. Toronto: Robert Rose Inc., September 2009.

Matthews SG, Phillips DI. Minireview: transgenerational inheritance of the stress response: a new frontier in stress research. Endocrinology 2010 Jan;151(1):7-13. Epub 2009 Nov 3. Review.

Maxwell C, Poppas A, Sermer M. Heart disease in pregnancy. In: Powrie R, Greene M, Camann W, eds. de Swiet's Medical Disorders in Obstetric Practice, 5th edition. Wiley-Blackwell: Toronto, June 2010, Chapter 5.

62 PUBLICATIONS 2009-2010

Mayer CM, Fick LJ, Gingerich S, Belsham DD. Hypothalamic cell lines to investigate neuroendocrine control mechanisms. Front Neuroendocrinol 2009 Aug;30(3):405-23. Epub 2009 Mar 31. Review.

McGee J, Covens A. State of the art of sentinel lymph node biopsy in vulvar carcinoma. Womens Health (Lond Engl) 2009 Sep;5(5):555-63.

McDonald SD, Han Z, Mulla S, Murphy KE, Beyene J, Ohlsson A; Knowledge Synthesis Group. Preterm birth and low birth weight among in vitro fertilization singletons: A systematic review and meta- analyses. Eur J Obstet Gynecol Reprod Biol 2009 Oct;146(2):138-48. Epub 2009 Jul 4. Review.

McDonald SD, Han Z, Mulla S, Ohlsson A, Beyene J, Murphy KE; Knowledge Synthesis Group. Preterm birth and low birth weight among in vitro fertilization twins: A systematic review and meta- analyses. Eur J Obstet Gynecol Reprod Biol 2010 Feb;148(2):105-13. Review.

Murphy KE. H1N1 Clinical Case Scenario. Toronto Invasive Bacterial Diseases Network, Volume 4, Issue 2, January 2010.

Murphy KE. Promotion of fetal maturation. In: Berghella V, ed., Preterm Birth: Prevention and Management. Wiley-Blackwell: Toronto, May 3, 2010, Chapter 20, p 232.

Narod SA. Genes, the environment, and breast cancer. Lancet 2010 Jun 19;375(9732):2123-4.

Oppenheimer LW, Farine D. A new classification of placenta previa: Measuring progress in obstetrics. Am J Obstet Gynecol 2009 Sep;201(3):227-9.

Ralston A, Rossant J. The genetics of induced pluripotency. Reproduction 2010 Jan;139(1):35-44. Epub . Review.

Robertson D, Lefebvre G, Leyland N, Wolfman W, Allaire C, Awadalla A, Best C, Contestabile E, Dunn S, Heywood M, Leroux N, Potestio F, Rittenberg D, Senikas V, Soucy R, Singh S; Society of Obstetricians and Gynaecologists of Canada. Adhesion prevention in gynaecological surgery. J Obstet Gynaecol Can 2010 Jun;32(6):598-608.

Rogers IM. Transdifferentiation of endogenous cells: Cell therapy without the cells. Cell Cycle 2009 Dec; 8(24):4023-8.

Rohrbach M, Chitayat D, Maegawa G, Shanske S, Davidzon G, Chong K, Clarke JT, Toi A, Tarnopolsky M, Robinson B, Blaser S. Intracerebral periventricular pseudocysts in a fetus with mitochondrial depletion syndrome: An association or coincidence. Fetal Diagn Ther 2009;25(2):177-82. Epub 2009 Mar 25. Roifman CM, Chitayat D. Combined immunodeficiency, facial dysmorphism, optic nerve atrophy, skeletal anomalies and developmental delay: a new syndrome. Clin Genet 2009 Nov;76(5):449-57.

Shier M. Fibroepithelial stromal polyp of the vulva. J Obstet Gynaecol Can 2009 Nov;31(11):1009-10.

63 PUBLICATIONS 2009-2010

Silversides CK, Sermer M, Siu SC. Choosing the best contraceptive method for the adult with congenital heart disease. Curr Cardiol Rep 2009 Jul;11(4):298-305. Review.

Infertility and Gynecology, 2nd edition. Jaypee Brs. Medical Publications (P) Ltd.: New Delhi, 2010, Chapter 3.

Thistle P. Running a hospital amid one trillion percent inflation. In: Carruthers C, ed. Lessons learned: Reflections of Canadian physician leaders. Ottawa: CMA, 2009.

Tone AA, Letarte M, Brown TJ. Emerging concepts in epithelial ovarian cancer: highlights of the 4th Canadian conference on ovarian cancer research. Eur J Gynaecol Oncol 2009;30(6):625-30.

Van Eyk N, Allen L, Giesbrecht E, Jamieson MA, Kives S, Morris M, Ornstein M, Fleming N. Pediatric vulvovaginal disorders: A diagnostic approach and review of the literature. J Obstet Gynaecol Can 2009 Sep;31(9):850-62.

Vicus D, Covens A, Small W. Ovarian Cancer in Clinical Radiation Oncology third edition, editors Gunderson L, Tepper J, and Thomas G. Elsevier, Philadelphia, 2010.

Vigod SN, Stewart DE. Emergent research in the cause of mental illness in women across the lifespan. Curr Opin Psychiatry 2009 Jul;22(4):396-400. Review.

Weksberg R, Shuman C. Beckwith-Wiedemann syndrome and hemihypertrophy. In: Cassidy SB, Allanson JE, eds., Management of Genetic Syndromes, 3rd ed. Wiley-Blackwell: New York, 2010, Chapter 10.

Wong C, Rogers IM, Cell therapy for kidney disease. J Am Soc Nephrol 2009 Nov; 20(11):2279-81.

Yinon Y, Farine D, Yudin MH, Gagnon R, Hudon L, Basso M, Bos H, Delisle MF, Menticoglou S, Mundle W, Ouellet A, Pressey T, Roggensack A, Boucher M, Castillo E, Gruslin A, Money DM, Murphy K, Ogilvie G, Paquet C, Van Eyk N, van Schalkwyk J; Fetal Medicine Committee, Society of Obstetricians and Gynaecologists of Canada. Cytomegalovirus infection in pregnancy. J Obstet Gynaecol Can 2010 Apr;32(4):348-54.

Yonkers KA, Wisner KL, Stewart DE, Oberlander TF, Dell DL, Stotland N, Ramin S, Chaudron L, Lockwood C. The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists. Obstet Gynecol 2009 Sep;114(3):703-13. Review.

Yudin MH. HPV vaccination: Time to end the debate. J Pediatr Adolesc Gynecol 2010 Feb;23(1):55-6.

Yudin MH, van Schalkwyk J, Van Eyk N, Boucher M, Castillo E, Cormier B, Gruslin A, Money DM, Murphy K, Ogilvie G, Paquet C, Steenbeek A, Wong T, Gagnon R, Hudon L, Basso M, Bos H, Delisle MF, Farine D, Grabowska K, Menticoglou S, Mundle WR, Murphy-Kaulbeck LC, Ouellet A, Pressey T, Roggensack A; Society of Obstetricians and Gynaecologists of Canada. Antibiotic therapy in preterm premature rupture of the membranes. J Obstet Gynaecol Can 2009 Sep;31(9):863-7, 868-74. Review PUBLICATIONS 2010-2011 64

PEER-REVIEWED PUBLICATIONS 2010-2011 Original Research

Aggarwal A, Spitzer RF, Caccia N, Stephens D, Johnstone J, Allen L. Repeat screening for sexually transmitted infection in adolescent obstetric patients. J Obstet Gynaecol Can 2010 Oct;32(10):956-61.

Al Riyami N, Hui D, Herer E, Nevo O. Uterine Compression Sutures as an Effective Treatment for Postpartum Hemorrhage: Case Series. Am J Perinatol Rep 2011; 1(1):47-52

Alarab M, Bortolini MA, Drutz H, Lye S, Shynlova O. LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse. Int Urogynecol J 2010 Nov;21(11):1397-404. Epub 2010 Jun 18.

Alfaraj MA, Ryan G, Langer JC, Windrim R, Seaward PG, Kingdom J. Does gastric dilation predict adverse perinatal or surgical outcome in fetuses with gastroschisis? Ultrasound Obstet Gynecol 2011 Feb;37(2):202-6. doi: 10.1002/uog.8868. Epub 2010 Dec 14.

Allen LM, Lucco KL, Brown CM, Spitzer RF, Kives S. Psychosexual and functional outcomes after creation of a neovagina with laparoscopic Davydov in patients with vaginal agenesis. Fertil Steril 2010 Nov;94(6):2272-6. Epub 2010 Mar 16.

Allingham-Hawkins DJ, Chitayat D, Cirigliano V, Summers A, Tokunaga J, Winsor E, Chun K. Prospective validation of quantitative fluorescent polymerase chain reaction for rapid detection of common aneuploidies. Genet Med 2011 Feb;13(2):140-7.

Amsalem H, Fitzgerald B, Keating S, Ryan G, Keunen J, Pippi Salle JL, Berger H, Aiello H, Otaño L, Bernier F, Chitayat D. Congenital megalourethra: Prenatal diagnosis and postnatal/autopsy findings in 10 cases. Ultrasound Obstet Gynecol 2011 Jun;37(6):678-83. doi: 10.1002/uog.8862. Epub 2011 May 5.

Awong G, Herer E, La Motte-Mohs RN, Zúñiga-Pflücker JC. Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature. BMC Immunol 2011 Mar 23;12:22.

Baczyk D, Kingdom JC, Uhlén P. Calcium signaling in placenta. Cell Calcium 2011 May;49(5):350-6. Epub 2011 Jan 14.

Balint OH, Siu SC, Mason J, Grewal J, Wald R, Oechslin EN, Kovacs B, Sermer M, Colman JM, Silversides CK. Cardiac outcomes after pregnancy in women with congenital heart disease. Heart 2010 Oct;96(20):1656-61.

Barker A, Sharp SJ, Timpson NJ, Bouatia-Naji N, Warrington NM, Kanoni S, Beilin LJ, Brage S, Deloukas P, Evans DM, Grontved A, Hassanali N, Lawlor DA, Lecoeur C, Loos RJ, Lye SJ, McCarthy MI, Mori TA, Ndiaye NC, Newnham JP, Ntalla I, Pennell CE, St Pourcain B, Prokopenko I, Ring SM, Sattar N, Visvikis-Siest S, Dedoussis GV, Palmer LJ, Froguel P, Smith GD, Ekelund U, Wareham NJ, Langenberg C. Association of genetic Loci with glucose levels in childhood and adolescence: a meta- analysis of over 6,000 children. Diabetes 2011 Jun;60(6):1805-12. Epub 2011 Apr 22. Barnett CP, Chitayat D, Bradley TJ, Wang Y, Hinek A. Dexamethasone normalizes aberrant elastic fiber production and collagen 1 secretion by Loeys-Dietz syndrome fibroblasts: A possible treatment? Eur J Hum Genet 2011 Jun;19(6):624-33. Epub 2011 Jan 26. PUBLICATIONS 2010-2011 65

Barnett CP, Wilson GJ, Chiasson DA, Gross GJ, Hinek A, Hawkins C, Chitayat D. Central nervous system abnormalities in two cases with neonatal Marfan syndrome with novel mutations in the fibrillin-1 gene. Am J Med Genet A 2010 Sep;152A(9):2409-12. IEEE Trans Biomed Eng 2011 Apr;58(4):935-42. Epub 2010 Dec 13.

Bedaiwy MA, Abdelaleem MA, Hussein M, Mousa N, Brunengraber LN, Casper RF. Hormonal, follicular and endometrial dynamics in letrozole-treated versus natural cycles in patients undergoing controlled ovarian stimulation. Reprod Biol Endocrinol 2011 Jun 21;9:83.

Bentov Y, Burstein E, Esfandiari N, Casper RF. Use of letrozole challenge test to adjust gonadotropin dose in non-down-regulated cycles. Fertil Steril 2011 Jun 30;95(8):2492-3. Epub 2011 Apr 9.

Billingsley G, Bin J, Fieggen KJ, Duncan JL, Gerth C, Ogata K, Wodak SS, Traboulsi EI, Fishman GA, Paterson A, Chitayat D, Knueppel T, Millán JM, Mitchell GA, Deveault C, Héon E. Mutations in chaperonin-like BBS genes are a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. J Med Genet 2010 Jul;47(7):453-63. Epub 2010 May 14.

Bortolini MA, Shynlova O, Drutz HP, Girão MJ, Castro RA, Lye S, Alarab M. Expression of bone morphogenetic protein-1 in vaginal tissue of women with severe pelvic organ prolapse. Am J Obstet Gynecol 2011 Jun;204(6):544.e1-8. Epub 2011 Mar 11.

Chang KT, Keating S, Costa S, Machin G, Kingdom J, Shannon P. Third trimester stillbirths: Correlative neuropathology and placental pathology. Pediatr Dev Pathol 2011 Feb 23. [Epub ahead of print]

Chivers ML, Pittini R, Grigoriadis S, Villegas L, Ross LE. The relationship between sexual functioning and depressive symptomatology in postpartum women: A pilot study. J Sex Med 2011 Mar;8(3):792-9. doi: 10.1111/j.1743-6109.2010.02154.x. Epub 2010 Dec 22.

Choufani S, Shapiro JS, Susiarjo M, Butcher DT, Grafodatskaya D, Lou Y, Ferreira JC, Pinto D, Scherer SW, Shaffer LG, Coullin P, Caniggia I, Beyene J, Slim R, Bartolomei MS, Weksberg R. A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes. Genome Res. 2011 Mar;21(3):465-76. Epub 2011 Feb 7.

Chua SJ, Bielecki R, Yamanaka N, Fehlings MG, Rogers IM, Casper RF. The effect of umbilical cord blood cells on outcomes after experimental traumatic spinal cord injury. Spine (Phila Pa 1976) 2010 Jul 15;35(16):1520-6.

Covens AL, Filiaci V, Gersell D, Lutman CV, Bonebrake A, Lee YC. Phase II study of fulvestrant in recurrent/metastatic endometrial carcinoma: A Gynecologic Oncology Group study. Gynecol Oncol 2011 Feb;120(2):185-8. Epub 2010 Nov 13.

Chung B, Shaffer LG, Keating S, Johnson J, Casey B, Chitayat D. From VACTERL-H to heterotaxy: Variable expressivity of ZIC3-related disorders. Am J Med Genet A 2011 May;155A(5):1123-8. doi: 10.1002/ajmg.a.33859. Epub 2011 Apr 4. Cleary JD, Tomé S, López Castel A, Panigrahi GB, Foiry L, Hagerman KA, Sroka H, Chitayat D, Gourdon G, Pearson CE. Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus. Nat Struct Mol Biol 2010 Sep;17(9):1079-87. Epub 2010 Aug 15.

PUBLICATIONS 2010-2011 66

Devarajan K, Seaward PG, Farine D. Attitudes among Toronto obstetricians towards vaginal breech delivery. J Obstet Gynaecol Can 2011 May;33(5):437-42.

Deveault C, Billingsley G, Duncan JL, Bin J, Theal R, Vincent A, Fieggen KJ, Gerth C, Noordeh N, Traboulsi EI, Fishman GA, Chitayat D, Knueppel T, Millán JM, Munier FL, Kennedy D, Jacobson SG, Innes AM, Mitchell GA, Boycott K, Héon E. BBS genotype-phenotype assessment of a multiethnic patient cohort calls for a revision of the disease definition. Hum Mutat 2011 Jun;32(6):610-9. doi: 10.1002/humu.21480. Epub 2011 Mar 22.

Drewlo S, Czikk M, Baczyk D, Lye S, Kingdom J. Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi. Hum Reprod 2011 May;26(5):1025-34. Epub 2011 Mar 15.

Ebrahimi N, Vohra S, Gedeon C, Akoury H, Bernstein P, Pairaudeau N, Cormier J, Dontigny L, Arsenault MY, Fortin C, Goyet M, Lafortune C, Lalande J, Beauchamp C, Engel F, Fortin A, Taddio A, Einarson T, Koren G. The fetal safety of hydrocortisone-pramoxine (Proctofoam-HC) for the treatment of hemorrhoids in late pregnancy. J Obstet Gynaecol Can 2011 Feb;33(2):153-8. Erratum in: J Obstet Gynaecol Can 2011 May;33(5):436.

Elit LM, Rosen B, Jimenez W, Giede C, Cybulska P, Sinasac S, Dodge J, Ayush E, Omenge O, Bernardini M, Finlayson S, McAlpine J, Miller D; International Community of Practice Committee of the Society of Gynecologic Oncology of Canada. Teaching cervical cancer surgery in low- or middle- resource countries. Int J Gynecol Cancer 2010 Dec;20(9):1604-8.

Esfandiari N, Javed MH, Nazemian Z, Casper RF. Fertilization and embryo development of fresh and cryopreserved sibling oocytes. Oct-Dec 2010:4(3);94-143.

Ezzat H, Ross S, von Dadelszen P, Morris T, Liston R, Magee LA; CPN Collaborative Group [Whittle W]. Ethics review as a component of institutional approval for a multicentre continuous quality improvement project: The investigator's perspective. BMC Health Serv Res 2010 Jul 30;10:223.

Fainaru O, Amsalem H, Bentov Y, Esfandiari N, Casper RF. CD56brightCD16- natural killer cells accumulate in the ovarian follicular fluid of patients undergoing in vitro fertilization. Fertil Steril 2010 Oct;94(5):1918-21. Epub 2010 Feb 10

Fainaru O, Firestone R, Casper RF. Oral nimodipine inhibits the ovarian cycle in mice. Fertil Steril 2011 Mar 15;95(4):1494-6. Epub 2010 Dec 31.

Ferreira JC, Choufani S, Grafodatskaya D, Butcher DT, Zhao C, Chitayat D, Shuman C, Kingdom J, Keating S, Weksberg R. WNT2 promoter methylation in human placenta is associated with low birthweight percentile in the neonate. Epigenetics 2011 Apr;6(4):440-9. Epub 2011 Apr 1.

Freedman OC, Dodge J, Shaw P, Oza AM, Bernardini M, Klachook S, Murphy KJ, Lo E, Rosen B, Mackay H. Diagnosis of epithelial ovarian carcinoma prior to neoadjuvant chemotherapy. Gynecol Oncol 2010 Oct;119(1):22-5. Epub 2010 Jun 29.

Fitzgerald B, Levytska K, Kingdom J, Walker M, Baczyk D, Keating S. Villous trophoblast abnormalities in extremely preterm deliveries with elevated second trimester maternal serum hCG or inhibin-A. Placenta 2011 Apr;32(4):339-45.

PUBLICATIONS 2010-2011 67

Fong K, Chong K, Toi A, Uster T, Blaser S, Chitayat D.Fetal ventriculomegaly secondary to isolated large choroid plexus cysts: Prenatal findings and postnatal outcome. Prenat Diagn 2011 Apr;31(4):395- 400. doi: 10.1002/pd.2703. Epub 2011 Feb 16.

Franco C, Walker M, Robertson J, Fitzgerald B, Keating S, McLeod A, Kingdom JC. Placental infarction and thrombophilia. Obstet Gynecol 2011 Apr;117(4):929-34.

Gien LT, Kupets R, Covens A. Feasibility of same-day discharge after laparoscopic surgery in gynecologic oncology. Gynecol Oncol 2011 May 1;121(2):339-43. Epub 2011 Feb 2.

Goh JM, Bensley JG, Kenna K, Sozo F, Bocking AD, Brien J, Walker D, Harding R, Black MJ. Alcohol exposure during late gestation adversely affects myocardial development with implications for postnatal cardiac function. Am J Physiol Heart Circ Physiol 2011 Feb;300(2):H645-51. Epub 2010 Nov 12.

Goldszmidt E, Macarthur A, Silversides C, Colman J, Sermer M, Siu S. Anesthetic management of a consecutive cohort of women with heart disease for labor and delivery. Int J Obstet Anesth 2010 Jul;19(3):266-72. Epub 2010 Mar 2.

Gracie SK, Lyon AW, Kehler HL, Pennell CE, Dolan SM, McNeil DA, Siever JE, McDonald SW, Bocking AD, Lye SJ, Hegadoren KM, Olson DM, Tough SC. All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment. BMC Pregnancy Childbirth 2010 Dec 30;10:87.

Grigoriu A, Ferreira JC, Choufani S, Baczyk D, Kingdom J, Weksberg R. Cell specific patterns of methylation in the human placenta. Epigenetics 2011 Mar;6(3):368-79. Epub 2011 Mar 1.

Guglietti CL, Rosen B, Murphy KJ, Laframboise S, Dodge J, Ferguson SE, Katz J, Ritvo P. Prevalence and predictors of post-traumatic stress in women undergoing an ovarian cancer investigation. Psychological Services 2010 Nov;7(4):266-74.

Hazan AD, Smith SD, Jones RL, Whittle W, Lye SJ, Dunk CE. Vascular-leukocyte interactions: mechanisms of human decidual spiral artery remodeling in vitro. Am J Pathol 2010 Aug;177(2):1017-30. Epub 2010 Jun 17.

Helpman L, Ferguson SE, Mackean M, Rana A, Le L, Atkinson MA, Rogerson A, Mackay H. Complementary and alternative medicine use among women receiving chemotherapy for ovarian cancer in 2 patient populations. Int J Gynecol Cancer 2011 Apr;21(3):587-93.

Herschorn S, Pommerville P, Stothers L, Egerdie B, Gajewski J, Carlson K, Radomski S, Drutz H, Schulz J, Barkin J, Hirshberg E, Corcos J. Tolerability of solifenacin and oxybutynin immediate release in older (> 65 years) and younger (≤ 65 years) patients with overactive bladder: Sub-analysis from a Canadian, randomized, double-blind study. Curr Med Res Opin 2011 Feb;27(2):375-82. Epub 2010 Dec 23.

Hughes MR, Anderson N, Maltby S, Wong J, Berberovic Z, Birkenmeier CS, Haddon DJ, Garcha K, Flenniken A, Osborne LR, Adamson SL, Rossant J, Peters LL, Minden MD, Paulson RF, Wang C, Barber DL, McNagny KM, Stanford WL. A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis. Exp Hematol 2011 Mar;39(3):305-20, 320.e1-2. Epub 2010 Dec 28. Erratum in: Exp Hematol. 2011 May 39(5):601. PUBLICATIONS 2010-2011 68

Hutton EK, Hannah ME, Ross SJ, Delisle MF, Carson GD, Windrim R, Ohlsson A, Willan AR, Gafni A, Sylvestre G, Natale R, Barrett Y, Pollard JK, Dunn MS, Turtle P; Early ECV2 Trial Collaborative Group. The Early External Cephalic Version (ECV) 2 Trial: An international multicentre randomised controlled trial of timing of ECV for breech pregnancies. BJOG 2011 Apr;118(5):564-77. doi: 10.1111/j.1471-0528.2010.02837.x. Epub 2011 Feb 4.

Huynh MH, Zhu SJ, Kollara A, Brown T, Winklbauer R, Ringuette M. Knockdown of SPARC leads to decreased cell-cell adhesion and lens cataracts during post-gastrula development in Xenopus laevis. Dev Genes Evol 2011 Mar;220(11-12):315-27. Epub 2011 Mar 8.

Imperatore A, Rolfo A, Petraglia F, Challis JR, Caniggia I. Hypoxia and preeclampsia: Increased expression of urocortin 2 and urocortin 3. Reprod Sci 2010 Sep;17(9):833-43. Epub 2010 Jul 8.

Jaeggi ET, Silverman ED, Laskin C, Kingdom J, Golding F, Weber R. Prolongation of the atrioventricular conduction in fetuses exposed to maternal anti-Ro/SSA and anti-La/SSB antibodies did not predict progressive heart block. A prospective observational study on the effects of maternal antibodies on 165 fetuses. J Am Coll Cardiol 2011 Mar 29;57(13):1487-92.

Kibschull M, Mileikovsky M, Michael IP, Lye SJ, Nagy A. Human embryonic fibroblasts support single cell enzymatic expansion of human embryonic stem cells in xeno-free cultures. Stem Cell Res 2011 Jan;6(1):70-82. Epub 2010 Aug 27.

Klieger-Grossmann C, Chitayat D, Lavign S, Kao K, Garcia-Bournissen F, Quinn D, Luo V, Sermer M, Riordan S, Laskin C, Matok I, Gorodischer R, Chambers C, Levi A, Koren G. Prenatal exposure to mycophenolate mofetil: an updated estimate. J Obstet Gynaecol Can 2010 Aug;32(8):794-7.

Kollara A, Brown TJ. Variable expression of nuclear receptor coactivator 4 (NcoA4) during mouse embryonic development. J Histochem Cytochem 2010 Jul;58(7):595-609. Epub 2010 Mar 30.

Krizova A, Clarke BA, Bernardini MQ, James S, Kalloger SE, Boerner SL, Mulligan AM. Histologic artifacts in abdominal, vaginal, laparoscopic, and robotic hysterectomy specimens: a blinded, retrospective review. Am J Surg Pathol 2011 Jan;35(1):115-26.

Kroft J, Moody JR, Lee P. Canadian hysterectomy educational experience: Survey of recent graduates in obstetrics and gynecology. J Minim Invasive Gynecol 2011 Jul-Aug;18(4):438-44. Epub 2011 May 12.

Kupets R, Paszat L. How are women with high grade Pap smear abnormalities managed? A population based study. Gynecol Oncol 2011 Jun 1;121(3):499-504. Epub 2011 Feb 26.

Kupets R, Paszat L. Physician and patient factors associated with follow up of high grade dysplasias of the cervix: A population-based study. Gynecol Oncol 2011 Jan;120(1):63-7. Epub 2010 Oct 12.

Laguë MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson SL, Boerboom D. Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab 2010 Dec;299(6):E936-46. Epub 2010 Sep 21.

Lermer MA, Morra A, Moineddin R, Manson J, Blake J, Tierney MC. Somatic and affective anxiety symptoms and menopausal hot flashes. Menopause 2011 Feb;18(2):129-32.

Leung C, Lu Z, Esfandiari N, Casper RF, Sun Y. Automated sperm immobilization for intracytoplasmic sperm injection. IEEE Trans Biomed Eng. 2011 Apr;58(4):935-42. Epub 2010 Dec 13. PUBLICATIONS 2010-2011 69

Ley SH, O'Connor DL, Retnakaran R, Hamilton JK, Sermer M, Zinman B, Hanley AJ. Impact of maternal metabolic abnormalities in pregnancy on human milk and subsequent infant metabolic development: Methodology and design. BMC Public Health 2010 Oct 6;10:590.

Li W, Li H, Bocking AD, Challis JR. Tumor necrosis factor stimulates matrix metalloproteinase 9 secretion from cultured human chorionic trophoblast cells through TNF receptor 1 signaling to IKBKB- NFKB and MAPK1/3 pathway. Biol Reprod 2010 Sep;83(3):481-7. Epub 2010 May 12.

Liu X, Fernandes R, Gertsenstein M, Perumalsamy A, Lai I, Chi M, Moley KH, Greenblatt E, Jurisica I, Casper RF, Sun Y, Jurisicova A. Automated microinjection of recombinant BCL-X into mouse zygotes enhances embryo development. PLoS One 2011;6(7):e21687. Epub 2011 Jul 20.

Liu X, Fernandes R, Jurisicova A, Casper RF, Sun Y. In situ mechanical characterization of mouse oocytes using a cell holding device. Lab Chip 2010 Aug 21;10(16):2154-61. Epub 2010 Jun 14.

López Castel A, Nakamori M, Tomé S, Chitayat D, Gourdon G, Thornton CA, Pearson CE. Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues. Hum Mol Genet 2011 Jan 1;20(1):1-15. Epub 2010 Nov 1.

Ly JP, Onay T, Sison K, Sivaskandarajah G, Sabbisetti V, Li L, Bonventre JV, Flenniken A, Paragas N, Barasch JM, Adamson SL, Osborne L, Rossant J, Schnermann J, Quaggin SE. The Sweet Pee model for Sglt2 mutation. J Am Soc Nephrol 2011 Jan;22(1):113-23.

Madadi P, Ciszkowski C, Gaedigk A, Leeder JS, Teitelbaum R, Chitayat D, Koren G. Genetic transmission of cytochrome P450 2D6 (CYP2D6) ultrarapid metabolism: Implications for breastfeeding women taking codeine. Curr Drug Saf 2011 Feb 1;6(1):36-9.

Madadi P, Joly Y, Avard D, Chitayat DC, Smith MA, D Ross CJ, Carleton BC, Hayden MR, Koren G. The communication of pharmacogenetic research results: participants weigh in on their informational needs in a pilot study. J Popul Ther Clin Pharmacol 2011;18:e152-5. Epub 2011 Mar 21.

Magee LA, von Dadelszen P, Allen VM, Ansermino JM, Audibert F, Barrett J, Brant R, Bujold E, Crane JM, Demianczuk N, Joseph KS, Lee SK, Piedboeuf B, Smith G, Synnes A, Walker M, Whittle W, Wood S, Lee T, Li J, Payne B, Liston RM; Canadian Perinatal Network Collaborative Group. The Canadian Perinatal Network: a national network focused on threatened preterm birth at 22 to 28 weeks' gestation. J Obstet Gynaecol Can 2011 Feb;33(2):111-20.

Malvasi A, Tinelli A, Guido M, Zizza A, Farine D, Stark M. Should the visceral peritoneum at the bladder flap closed at cesarean sections? A post-partum sonographic and clinical assessment. J Matern Fetal Neonatal Med 2010 Jul;23(7):662-9.

Maricich SM, Aqeeb KA, Moayedi Y, Mathes EL, Patel MS, Chitayat D, Lyon G, Leroy JG, Zoghbi HY. Pontocerebellar hypoplasia: Review of classification and genetics, and exclusion of several genes known to be important for cerebellar development. J Child Neurol 2011 Mar;26(3):288-94.

Maxwell C, Dunn E, Tomlinson G, Glanc P. How does maternal obesity affect the routine fetal anatomic ultrasound? J Matern Fetal Neonatal Med 2010 Oct;23(10):1187-92.

McCarthy FP, Kingdom JC, Kenny LC, Walsh SK. Animal models of preeclampsia; Uses and limitations. Placenta 2011 Jun;32(6):413-9. Epub 2011 Apr 17. PUBLICATIONS 2010-2011 70

McDermott CD, Moravac CC, Yudin MH. The effectiveness of screening for hepatitis C in pregnancy. J Obstet Gynaecol Can 2010 Nov;32(11):1035-41.

McDermott CD, Terry CL, Woodman PJ, Hale DS. Surgical outcomes following total Prolift: colpopexy versus hysteropexy. Aust N Z J Obstet Gynaecol 2011 Feb;51(1):61-6. doi: 10.1111/j.1479- 828X.2010.01258.x. Epub 2011 Jan 5.

McDermott CD, Park J, Terry CL, Woodman PJ, Hale DS. Laparoscopic sacral colpoperineopexy: Abdominal versus abdominal-vaginal posterior graft attachment. Int Urogynecol J 2011 Apr;22(4):469- 75. Epub 2010 Oct 20.

McDermott CD, Terry CL, Woodman PJ, Hale DS.The effect of tension-free vaginal tape placement on distal anterior vaginal wall support at the time of laparoscopic sacral colpoperineopexy. Arch Gynecol Obstet 2011 Jun;283(6):1303-7. Epub 2010 Jun 12.

McFadden E, Taleski SJ, Bocking A, Spitzer RF, Mabeya H. Retrospective review of predisposing factors and surgical outcomes in obstetric fistula patients at a single teaching hospital in Western Kenya. J Obstet Gynaecol Can 2011 Jan;33(1):30-5.

Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Chénier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer AM, Megarbane A, Mendelsohn NJ, Meschino WS, Mortier GR, Parkash S, Ray CR, Roberts A, Roberts A, Reardon W, Schnur RE, Smith R, Splitt M, Tezcan K, Whiteford ML, Wong DA, Zori R, Lin AE. Genotype-phenotype analysis of the branchio-oculo-facial syndrome. Am J Med Genet A 2011 Jan;155A(1):22-32. doi: 10.1002/ajmg.a.33783. Mittal P, Romero R, Tarca AL, Gonzalez J, Draghici S, Xu Y, Dong Z, Nhan-Chang CL, Chaiworapongsa T, Lye S, Kusanovic JP, Lipovich L, Mazaki-Tovi S, Hassan SS, Mesiano S, Kim CJ. Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term. J Perinat Med 2010 Nov;38(6):617-43. Epub 2010 Jul 14.

Murji A, Sobel ML, Feig DS, Sermer M. Propylthiouracil-induced agranulocytosis in the third trimester of pregnancy. Obstet Gynecol 2010 Aug;116 Suppl 2:485-7.

Murji A, Sobel ML, Hasan L, McLeod A, Waye JS, Sermer M, Berger H. Pregnancy outcomes in women with elevated levels of fetal hemoglobin. J Matern Fetal Neonatal Med 2011 Apr 7. [Epub ahead of print]

Nadeem L, Munir S, Fu G, Dunk C, Baczyk D, Caniggia I, Lye S, Peng C. Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: Implication in the pathogenesis of preeclampsia. Am J Pathol 2011 Mar;178(3):1177-89.

Nazemian Z, Esfandiari N, Javed M, Casper RF. The effect of age on in vitro fertilization outcome: Is too young possible? J Assist Reprod Genet 2011 Feb;28(2):101-6. Epub 2010 Nov 2.

Nevo O, Soustiel JF, Thaler I. Maternal cerebral blood flow during normal pregnancy: A cross-sectional study. Am J Obstet Gynecol 2010 Nov;203(5):475.e1-6.

Nevo O, Bronshtein M. Fetal transient occipital bone protuberance during early pregnancy. Prenat Diagn 2010 Sep;30(9):879-81.

PUBLICATIONS 2010-2011 71

Ohashi Y, Ibrahim H, Furtado L, Kingdom J, Carvalho JC. Non-invasive hemodynamic assessment of non-pregnant, healthy pregnant and preeclamptic women using bioreactance. [corrected]. Rev Bras Anestesiol 2010 Nov-Dec;60(6):603-13, 335-40. Erratum in: Rev Bras Anesthesiol 2011 Jul- Aug;61(4):IX.

Osborne RJ, Filiaci V, Schink JC, Mannel RS, Alvarez Secord A, Kelley JL, Provencher D, Scott Miller D, Covens AL, Lage JM. Phase III trial of weekly methotrexate or pulsed dactinomycin for low-risk gestational trophoblastic neoplasia: A gynecologic oncology group study. J Clin Oncol 2011 Mar 1;29(7):825-31. Epub 2011 Jan 24.

Proctor LK, Whittle WL, Keating S, Viero S, Kingdom JC. Pathologic basis of echogenic cystic lesions in the human placenta: Role of ultrasound-guided wire localization. Placenta 2010 Dec;31(12):1111-5. Epub 2010 Oct 29.

Rahman SA, Marcu S, Shapiro CM, Brown TJ, Casper RF. Spectral modulation attenuates molecular, endocrine, and neurobehavioral disruption induced by nocturnal light exposure. Am J Physiol Endocrinol Metab 2011 Mar;300(3):E518-27. Epub 2010 Dec 21.

Ranney ML, Rennert-May E, Spitzer R, Chitai MA, Mamlin SE, Mabeya H. A novel ED-based sexual assault centre in western Kenya: description of patients and analysis of treatment patterns.Emerg Med J 2011 Nov;28(11):927-31. Epub 2010 Oct 14.

Rennie MY, Detmar J, Whiteley KJ, Yang J, Jurisicova A, Adamson SL, Sled JG. Vessel tortuousity and reduced vascularization in the fetoplacental arterial tree after maternal exposure to polycyclic aromatic hydrocarbons. Am J Physiol Heart Circ Physiol 2011 Feb;300(2):H675-84. Epub 2010 Dec 10. Retnakaran R, Qi Y, Connelly PW, Sermer M, Hanley AJ, Zinman B. The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: Implications for future cardiovascular risk. J Clin Endocrinol Metab 2010 Sep;95(9):4345-53. Epub 2010 Jul 14.

Retnakaran R, Qi Y, Sermer M, Connelly PW, Zinman B, Hanley AJ. Gestational diabetes and postpartum physical activity: Evidence of lifestyle change 1 year after delivery. Obesity (Silver Spring) 2010 Jul;18(7):1323-9. Epub 2009 Oct 8.

Rolfo A, Many A, Racano A, Tal R, Tagliaferro A, Ietta F, Wang J, Post M, Caniggia I. Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies. PLoS One 2010 Oct 12;5(10):e13288.

Ross LE, Villegas L, Dennis CL, Bourgeault IL, Cairney J, Grigoriadis S, Steele LS, Yudin MH. Rural residence and risk for perinatal depression: a Canadian pilot study. Arch Womens Ment Health 2011 Jun;14(3):175-85. Epub 2011 Feb 11.

Saad RS, Ismiil N, Ghorab Z, Nofech-Mozes S, Dubé V, Covens A, Khalifa MA. Lymphatic vessel density as a prognostic marker in clinical stage I endocervical adenocarcinoma. Int J Gynecol Pathol 2010 Jul;29(4):386-93.

Shah P, Kingdom J. Long-term neurocognitive outcomes of SGA/IUGR infants. Obstetrics, Gynaecology & Reproductive Medicine 2011 May;21(5):142-6.

Shah RR, Ray JG, Taback N, Meffe F, Glazier RH. Adverse pregnancy outcomes among foreign-born Canadians. J Obstet Gynaecol Can 2011 Mar;33(3):207-15. PUBLICATIONS 2010-2011 72

Skupski DW, Luks FI, Walker M, Papanna R, Bebbington M, Ryan G, O'Shaughnessy R, Moldenhauer J, Bahtiyar O; North American Fetal Therapy Network (NAFTNet). Preoperative predictors of death in twin-to-twin transfusion syndrome treated with laser ablation of placental anastomoses. Am J Obstet Gynecol. 2010 Oct;203(4):388.e1-388.e11. Epub 2010 Aug 9.

Snape K, Hanks S, Ruark E, Barros-Núñez P, Elliott A, Murray A, Lane AH, Shannon N, Callier P, Chitayat D, Clayton-Smith J, Fitzpatrick DR, Gisselsson D, Jacquemont S, Asakura-Hay K, Micale MA, Tolmie J, Turnpenny PD, Wright M, Douglas J, Rahman N. Mutations in CEP57 cause mosaic variegated aneuploidy syndrome.Nat Genet 2011 Jun;43(6):527-9.Epub 2011 May 8.

Sobel ML, Kingdom J, Drewlo S. Angiogenic response of placental villi to heparin. Obstet Gynecol 2011 Jun;117(6):1375-83.

Soylu H, Jefferies A, Diambomba Y, Windrim R, Shah PS. Rupture of membranes before the age of viability and birth after the age of viability: Comparison of outcomes in a matched cohort study. J Perinatol 2010 Oct;30(10):645-9. Epub 2010 Mar 11.

Sozo F, Vela M, Stokes V, Kenna K, Meikle PJ, De Matteo R, Walker D, Brien J, Bocking A, Harding R. Effects of prenatal ethanol exposure on the lungs of postnatal lambs. Am J Physiol Lung Cell Mol Physiol 2011 Jan;300(1):L139-47. Epub 2010 Oct 29.

Stewart JM, Shaw PA, Gedye C, Bernardini MQ, Neel BG, Ailles LE. Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6468- 73. Epub 2011 Mar 30.

Tanous D, Siu SC, Mason J, Greutmann M, Wald RM, Parker JD, Sermer M, Colman JM, Silversides CK. B-type natriuretic peptide in pregnant women with heart disease. J Am Coll Cardiol 2010 Oct 5;56(15):1247-53.

Theisen A, Rosenfeld JA, Shane K, McBride KL, Atkin JF, Gaba C, Hoo J, Kurczynski TW, Schnur RE, Coffey LB, Zackai EH, Schimmenti L, Friedman N, Zabukovec M, Ball S, Pagon R, Lucas A, Brasington CK, Spence JE, Sparks S, Banks V, Smith W, Friedberg T, Wyatt PR, Aust M, Tervo R, Crowley A, Skidmore D, Lamb AN, Ravnan B, Sahoo T, Schultz R, Torchia BS, Sgro M, Chitayat D, Shaffer LG. Refinement of the region for split hand/foot malformation 5 on 2q31.1. Mol Syndromol 2010;1(5):262- 271. Epub 2011 May 18.

Thériault BL, Pajovic S, Bernardini MQ, Shaw PA, Gallie BL. Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer. Int J Cancer 2011 May 26. doi: 10.1002/ijc.26189. [Epub ahead of print]

Tierney MC, Moineddin R, Morra A, Manson J, Blake J. Intensity of recreational physical activity throughout life and later life cognitive functioning in women. J Alzheimers Dis 2010;22(4):1331-8.

Tobler D, Fernandes SM, Wald RM, Landzberg M, Salehian O, Siu SC, Colman JM, Sermer M, Silversides CK. Pregnancy outcomes in women with transposition of the great arteries and arterial switch operation. Am J Cardiol 2010 Aug 1;106(3):417-20.

Tone AA, Virtanen C, Shaw PA, Brown TJ. Decreased progesterone receptor isoform expression in luteal phase fallopian tube epithelium and high-grade serous carcinoma. Endocr Relat Cancer 2011 Feb 23;18(2):221-34. Print 2011 Apr.

PUBLICATIONS 2010-2011 73

TRIGR Study Group (Sermer M), Akerblom HK, Krischer J, Virtanen SM, Berseth C, Becker D, Dupré J, Ilonen J, Trucco M, Savilahti E, Koski K, Pajakkala E, Fransiscus M, Lough G, Bradley B, Koski M, Knip M. The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up. Diabetologia 2011 Mar;54(3):627-33. Epub 2010 Dec 12. Erratum in: Diabetologia. 2011 Aug;54(8):2210. van Dijk M, van Bezu J, van Abel D, Dunk C, Blankenstein MA, Oudejans CB, Lye SJ. The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation. Hum Mol Genet 2010 Jul 1;19(13):2658-67. Epub 2010 Apr 16. vanderVaart S, Berger H, Tam C, Goh1 YI, Gijsen VMGJ, de Wildt SN, Taddio A, Koren G. The effect of distant reiki on pain in women after elective Caesarean section: A double-blinded randomised controlled trial. BMJ Open 2011 Feb;1:e000021 doi:10.1136/bmjopen-2010-000021

Walker MG, Hindmarsh PC, Geary M, Kingdom JC. Sonographic maturation of the placenta at 30 to 34 weeks is not associated with second trimester markers of placental insufficiency in low-risk pregnancies. J Obstet Gynaecol Can 2010 Dec;32(12):1134-9.

Wang Q, Chow J, Hong J, Smith AF, Moreno C, Seaby P, Vrana P, Miri K, Tak J, Chung ED, Mastromonaco G, Caniggia I, Varmuza S. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. BMC Genomics 2011 Apr 21;12:204.

Windrim C, Athaide G, Gerster T, Kingdom JC. Sonographic findings and clinical outcomes in women with massive subchorionic hematoma detected in the second trimester. J Obstet Gynaecol Can 2011 May;33(5):475-9.

Winsor EJ, Akoury H, Chitayat D, Steele L, Stockley TL. The role of molecular microsatellite identity testing to detect sampling errors in prenatal diagnosis. Prenat Diagn 2010 Aug;30(8):746-52.

Wright JK, Dunk CE, Amsalem H, Maxwell C, Keating S, Lye SJ. HER1 signaling mediates extravillous trophoblast differentiation in humans. Biol Reprod 2010 Dec;83(6):1036-45. Epub 2010 Aug 25.

Yeganegi M, Leung CG, Martins A, Kim SO, Reid G, Challis JR, Bocking AD. Lactobacillus rhamnosus GR-1-induced IL-10 production in human placental trophoblast cells involves activation of JAK/STAT and MAPK pathways. Reprod Sci 2010 Nov;17(11):1043-51. Epub 2010 Sep 21.

Yeganegi M, Leung CG, Martins A, Kim SO, Reid G, Challis JR, Bocking AD. Lactobacillus rhamnosus GR-1 stimulates colony-stimulating factor 3 (granulocyte) (CSF3) output in placental trophoblast cells in a fetal sex-dependent manner. Biol Reprod 2011 Jan;84(1):18-25. Epub 2010 Sep 1

Yinon Y, Chitayat D, Blaser S, Seed M, Amsalem H, Yoo SJ, Jaeggi ET. Fetal cardiac tumors: a single- center experience of 40 cases. Prenat Diagn 2010 Oct;30(10):941-9.

Yinon Y, Grisaru-Granovsky S, Chaddha V, Windrim R, Seaward PG, Kelly EN, Beresovska O, Ryan G. Perinatal outcome following fetal chest shunt insertion for pleural effusion. Ultrasound Obstet Gynecol. 2010 Jul;36(1):58-64.

Yinon Y, Visser J, Kelly EN, Windrim R, Amsalem H, Seaward PG, Ryan G. Early intrauterine transfusion in severe red blood cell alloimmunization. Ultrasound Obstet Gynecol 2010 Nov;36(5):601-6. doi: 10.1002/uog.7696. PUBLICATIONS 2010-2011 74

Yinon Y, Kingdom JC, Odutayo A, Moineddin R, Drewlo S, Lai V, Cherney DZ, Hladunewich MA. Vascular dysfunction in women with a history of preeclampsia and intrauterine growth restriction: Insights into future vascular risk. Circulation 2010 Nov 2;122(18):1846-53. Epub 2010 Oct 18.

Zelinski MB, Murphy MK, Lawson MS, Jurisicova A, Pau KY, Toscano NP, Jacob DS, Fanton JK, Casper RF, Dertinger SD, Tilly JL. In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates. Fertil Steril 2011 Mar 15;95(4):1440-5.e1-7.

Zhang S, Royer R, Li S, McLaughlin JR, Rosen B, Risch HA, Fan I, Bradley L, Shaw PA, Narod SA. Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer. Gynecol Oncol 2011 May 1;121(2):353-7. Epub 2011 Feb 15. PUBLICATIONS 2010-2011 75

Invited Papers, Case Reports, Commentaries, Editorials, Reviews and Book Chapters

Allen VM, Campbell M, Carson G, Fraser W, Liston RM, Walker M, Barrett J; Canadian Maternal Morbidity Working Group (Sermer M). Maternal mortality and severe maternal morbidity surveillance in Canada. J Obstet Gynaecol Can 2010 Dec;32(12):1140-6. Review.

Amir E, Freedman O, Allen L, Colgan T, Clemons M. Defining ovarian failure in amenorrheic young breast cancer patients. Breast 2010 Dec;19(6):545-8. Epub 2010 Jul 7.

Berger H. Special care during pregnancy. In: Sacks DA. Ed, Diabetes & Pregnancy: A Guide to a Healthy Pregnancy. American Diabetes Association: Alexandria, 2011, Chapter 3.

Blake J. Things I learn from women… Blog. http://womenandhealth.sunnybrook.ca/

Bortolini MA, Drutz HP, Lovatsis D, Alarab M. Vaginal delivery and pelvic floor dysfunction: Current evidence and implications for future research. Int Urogynecol J 2010 Aug;21(8):1025-30. Epub 2010 May 6. Review.

Brown TJ, Shathasivam P. Maintaining mesenchymal properties of ovarian surface epithelial cells: a potential early protective role for TGF-beta in ovarian carcinogenesis. Endocrinology 2010 Nov;151(11):5092-4. Editorial

Cameron JM, Levandovskiy V, Mackay N, Ackerley C, Chitayat D, Raiman J, Halliday WH, Schulze A, Robinson BH. Complex V TMEM70 deficiency results in mitochondrial nucleoid disorganization. Mitochondrion 2011 Jan;11(1):191-9. Epub 2010 Oct 30.

Chu L, Seed M, Howse E, Ryan G, Grosse-Wortmann L. Mesenchymal hamartoma: prenatal diagnosis by MRI. Pediatr Radiol 2011 Jun;41(6):781-4. Epub 2010 Dec 1.

Chung HY, Chu L, Forrest C, Silver R, Toi A, Blaser S, Viero S, Taylor G, Chitayat D. Fetal forehead hemangiopericytoma: prenatal diagnosis and postnatal outcome. Ultrasound Obstet Gynecol 2010 Jul;36(1):121-4.

Chung HY, Uster-Friedberg T, Pentaz S, Blaser S, Murphy K, Chitayat D. Enlarged parietal foramina: Findings on prenatal ultrasound and magnetic resonance imaging. Ultrasound Obstet Gynecol 2010 Oct;36(4):521-2.

Cruickshank BE. Umbilical Cord Blood Banking. Birth of a Mother. October/November 2010, p. 20-3.

Davies GA, Maxwell C, McLeod L, Gagnon R, Basso M, Bos H, Delisle MF, Farine D, Hudon L, Menticoglou S, Mundle W, Murphy-Kaulbeck L, Ouellet A, Pressey T, Roggensack A, Leduc D, Ballerman C, Biringer A, Duperron L, Jones D, Lee LS, Shepherd D, Wilson K; Society of Obstetricians and Gynaecologists of Canada. SOGC Clinical Practice Guidelines: Obesity in pregnancy. No. 239, February 2010. Int J Gynaecol Obstet 2010 Aug;110(2):167-73.

Drewlo S, Walker M, McLeod A, Dodd J, Kingdom J. Heparin in human placental development and the prevention of placental complications of pregnancy. Fetal and Maternal Medicine Review 2010; 21:3 185–203. PUBLICATIONS 2010-2011 76

Drutz HP. Overactive bladder: The importance of tailoring treatment to the individual patient. J Multidiscip Healthc 2011;4:233-7. Epub 2011 Jul 22.

Drutz HP; IUGA Education Committee. IUGA guidelines for training in female pelvic medicine and reconstructive pelvic surgery (FPM-RPS). Updated guidelines 2010. Int Urogynecol J. 2010 Dec;21(12):1445-53.

Dubé V, Chun K, Osborne R, Sherman C, Nofech-Mozes S, Ismiil N, Saad RS, Khalifa MA. Androgenetic complete mole with trisomy 13: Report of a case with microsatellite genotyping and review of the literature. Pathol Res Pract 2010 Nov 15;206(11):776-81. Epub 2010 Apr 18.

Dunk C, Drewlo S, Proctor L, Kingdom JCP. New concepts and recommendations on clinical management and research. In: Pijnenborg R, Brosens I, Romero R, editors. Placental Bed Disorders, 1st ed., Cambridge: Cambridge University Press; 2010. p. 256-70.

Eiriksson L, Covens A. Conservative surgery for early stage cervical cancer: Who should we offer it to? Gyne Onc 2010 November;119(2):173-4. Editorial

Epp A, Larochelle A, Lovatsis D, Walter JE, Easton W, Farrell SA, Girouard L, Gupta C, Harvey MA, Robert M, Ross S, Schachter J, Schulz JA, Wilkie D, Ehman W, Domb S, Gagnon A, Hughes O, Konkin J, Lynch J, Marshall C, Society of Obstetricians and Gynaecologists of Canada. Recurrent urinary tract infection. J Obstet Gynaecol Can 2010 Nov;32(11):1082-101. Review.

Fong KW, Robertson JE, Maxwell CV. The Fetal Urogenital Tract. In: Rumack CM, Wilson SR, Charboneau JW, Levine D, editors. Diagnostic Ultrasound. 4th ed. Philadelphia: Elsevier Mosby; 2011. Chapter 39, p. 1353-88.

Ghosh N, Luk A, Derzko C, Dorian P, Chow CM.The acute treatment of maternal supraventricular tachycardias during pregnancy: A review of the literature. J Obstet Gynaecol Can 2011 Jan;33(1):17-23.

Gien LT, Covens A. Principles of Laparoscopic Surgery. In: Ayhan A, Gultekin M, Dursun P, editors. Textbook of Gynecologic Oncology, 2nd ed. Gunes Publishing: Ankara, August 2010. Chapter 55, p.266- 9.

Giuffrida D, Rogers IM. Targeting cancer stem cell lines as a new treatment of human cancer. Recent Pat Anticancer Drug Discov 2010 Nov;5(3):205-18.

Glanc P, Maxwell C. Acute abdomen in pregnancy: Role of sonography. J Ultrasound Med 2010 Oct;29(10):1457-68.

Hutter D, Kingdom J, Jaeggi E. Causes and mechanisms of intrauterine hypoxia and its impact on the fetal cardiovascular system: A review. Int J Pediatr 2010;2010:401323. Epub 2010 Oct 19.

Jain Ghai S, Keating S, Chitayat D. PTPN11 gene mutation associated with abnormal gonadal determination. Am J Med Genet A 2011 May;155A(5):1136-9. doi: 10.1002/ajmg.a.33873. Epub 2011 Apr 4.

Jones C, Chan C, Farine D. Sex in pregnancy. CMAJ 2011 Apr 19;183(7):815-8. Epub 2011 Jan 31. Review.

PUBLICATIONS 2010-2011 77

Jones C, Liu K. Pregnancy after modified natural cycle IVF: Case report of a young patient with elevated FSH levels and male factor infertility. J Obstet Gynaecol Can 2011 Feb;33(2):139-41.

Kazmin A, Wong RC, Sermer M, Koren G. Antiepileptic drugs in pregnancy and hemorrhagic disease of the newborn: An update. Can Fam Physician 2010 Dec;56(12):1291-2.

Kew S, Qi Y, Sermer M, Connelly PW, Hanley AJ, Zinman B, Retnakaran R. Relationship between short stature and postchallenge glycemia in pregnancy. Diabetes Care 2010 Dec;33(12):e173.

Leyland N, Casper R, Laberge P, Singh SS; SOGC. Endometriosis: Diagnosis and management. J Obstet Gynaecol Can 2010 Jul;32(7 Suppl 2):S1-32.

Liu KE, Shapiro J, Robertson D, Chamberlain S; Ethics committee; Society of Obstetricians and Gynaecologists of Canada Ethics Committee; Association of Professors of Obstetrics and Gynaecology of Canada Undergraduate Committee. Pelvic examinations by medical students. J Obstet Gynaecol Can 2010 Sep;32(9):872-7.

Lovatsis D, Easton W, Wilkie D; Society of Obstetricians and Gynaecologists of Canada Urogynaecology Committee. Guidelines for the evaluation and treatment of recurrent urinary incontinence following pelvic floor surgery. J Obstet Gynaecol Can 2010 Sep;32(9):893-904. Review.

Madadi P, Joly Y, Avard D, Chitayat DC, Smith MA, Ross CJ, Carleton BC, Hayden MR, Koren G. Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: a pilot study of perceptions and benefits. Clin Pharmacol Ther 2010 Dec;88(6):792-5. Epub 2010 Aug 25.

Malvasi A, Di Renzo GC, Farine D et al., editors. Ecografia intrapartum. Bari:Laterza Giuseppe Edizioni; 2011.

Maxwell C, Glanc P. Imaging and obesity: a perspective during pregnancy. AJR Am J Roentgenol 2011 Feb;196(2):311-9.

McCuaig JM, Greenwood C, Shuman C, Chitayat D, Murphy KJ, Rosen B, Armel SR. Breast and ovarian cancer: Y do we forget about dad? Lancet Oncol 2010 Dec;11(12):1115-7.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Intimacy and sexuality after treatment for gynecologic cancer. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011. Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Quick Fact Sheet about endometrial cancer. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Quick Fact Sheet about ovarian cancer. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Quick Fact Sheet about cervical cancer. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Quick Fact Sheet about vulvar cancer. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011. PUBLICATIONS 2010-2011 78

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Quick Fact Sheet about vaginal cancer. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Going home after hysterectomy – Discharge instructions for patients. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Preparing for your surgery – Information for patients receiving minimally invasive radical hysterectomy. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Preparing for your surgery – Information for patients recieving minimally invasive hysterectomy. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Preparing for your surgery – Information for patients recieving radical abdominal hysterectomy. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Preparing for your surgery - Information for patients recieving abdominal hysterectomy. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Preparing for your surgery – Information for patients receiving vulvectomy. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Chemotherapy: How to manage your chemotherapy side effects. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Papadakos J, Freeman A, Abdelmutti N, Ferguson SE. Chemotherapy: Your guide to intraperitoneal chemotherapy. PMH Educational and Supportive Care Pamphlets/PMH Cancer Program, 2011.

Ray JG, Berger H, Lipscombe LL, Sermer M. Gestational prediabetes: A new term for early prevention? Indian J Med Res 2010 Sep;132:251-5. Review.

Reid R, Leyland N, Wolfman W, Allaire C, Awadalla A, Best C, Dunn S, Lemyre M, Marcoux V, Menard C, Potestio F, Rittenberg D, Singh S, Senikas V; Society of Obstetricians and Gynaecologists of Canada. SOGC clinical practice guidelines: Oral contraceptives and the risk of venous thromboembolism: An update: No. 252, December 2010. Int J Gynaecol Obstet 2011 Mar;112(3):252-6.

Robertson D, Lefebvre G, Leyland N, Wolfman W, Allaire C, Awadalla A, Best C, Contestabile E, Dunn S, Heywood M, Leroux N, Potestio F, Rittenberg D, Senikas V, Soucy R, Singh S; Society of Obstetricians and Gynaecologists of Canada. SOGC clinical practice guidelines: Adhesion prevention in gynaecological surgery: no. 243, June 2010. Int J Gynaecol Obstet 2010 Nov;111(2):193-7.

Shaffer L, Chitayat D. Chromosomal microarrays: The benefits and challenges of introduction into prenatal diagnosis. Fetal and Maternal Medicine Review 2010;21(4):307-22.

Shier M, El-Khatib S. Vulvar lichen sclerosus. J Obstet Gynaecol Can 2010 Oct;32(10):929-30. PUBLICATIONS 2010-2011 79

Sidiropoulos M, Lausman A, Yudin M, Iakovlev VV. Rising incidence of syphilis infection in Canada: A case report of syphilitic placentitis. Can J Pathol 2010 Fall;2(3):19-22.

Sterling L, van Lonkhuijzen L, Nyangena J, Orango E, Strother M, Busakhala N, Rosen B. Protocol development for ovarian cancer treatment in Kenya: A brief report. Int J Gynecol Cancer 2011 Feb;21(2):424-7.

Todros T, Piccoli E, Rolfo A, Cardaropoli S, Guiot C, Gaglioti P, Oberto M, Vasario E, Caniggia I. Review: Feto-placental vascularization: A multifaceted approach. Placenta 2011 Mar;32 Suppl 2:S165-9. Epub 2011 Jan 13. Review.

Toi A, Levine D. The Fetal Brain. In: Rumack CM, Wilson SR, Charboneau JW, Levine D, editors. Diagnostic Ultrasound. 4th ed. Philadelphia: Elsevier Mosby; 2011, Chapter 34, p 1197-244. van Schalkwyk J, Van Eyk N, van Eyk N, Yudin MH, Boucher M, Cormier B, Gruslin A, Money DM, Ogilvie G, Castillo E, Paquet C, Steenbeek A, Wong T (Society of Obstetricians and Gynaecologists of Canada Infectious Diseases Committee). Antibiotic prophylaxis in obstetric procedures. J Obstet Gynaecol Can 2010 Sep;32(9):878-92. Review.

Vicus D, Covens A. Role of sentinel lymph node biopsy in cervical cancer: pro. Int J Gynecol Cancer 2010 Oct;20(11 Suppl 2):S34-6.

Walker M, Whittle W, Keating S, Kingdom J. Sonographic diagnosis of chronic abruption. J Obstet Gynaecol Can 2010 Nov;32(11):1056-8.

Walter JE; Urogynaecology Committee, Lovatsis D, Walter JE, Easton W, Epp A, Farrell SA, Girouard L, Gupta CK, Harvey MA, Larochelle A, Robert M, Ross S, Schachter J, Schultz JA, Wilkie DH; Society of Obstetricians and Gynaecologists of Canada. Transvaginal mesh procedures for pelvic organ prolapse. J Obstet Gynaecol Can 2011 Feb;33(2):168-74.

Warren R, Greenblatt E. Celiac disease and fertility. In: Dennis M, Leffler D, editors. Real Life with Celiac Disease: Troubleshooting and Thriving Gluten Free. Bethesda: AGA Press; 2010, p. 331-5. Whittle W, Fong KW, Windrim R. Cervical Ultrasound and Preterm Birth. In: Rumack CM, Wilson SR, Charboneau JW, Levine D, editors. Diagnostic Ultrasound. 4th ed. Philadelphia: Elsevier Mosby; 2011, Chapter 45, p. 1527-42.

Windrim R. ACP Journal Club. PPI use in the first trimester was not associated with increased risk for birth defects; PPI use 1 to 4 weeks before conception was. Ann Intern Med 2011 Jun 21;154(12):JC6-11.

Wolfman W, Leyland N, Heywood M, Singh SS, Rittenberg DA, Soucy R, Allaire C, Awadalla A, Best C, Dunn S, Leroux N, Potestio F, Senikas V, Wallace S, Menzies R, Society of Obstetricians and Gynaecologists of Canada. Asymptomatic endometrial thickening. J Obstet Gynaecol Can 2010 Oct;32(10):990-9. Review

Yinon Y, Farine D, Yudin MH. Screening, diagnosis, and management of cytomegalovirus infection in pregnancy. Obstet Gynecol Surv 2010 Nov;65(11):736-43. Review.

Yudin MH, Loutfy M. Advocating for assistance with pregnancy planning in HIV-positive individuals and couples: An idea whose time has come. J Obstet Gynaecol Can 2011 Mar;33(3):269-71.

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Yudin MH. Other infectious conditions. In: James DK, Steer PJ, Weiner CP, Gonik B, Crowther C, Robson S. High Risk Pregnancy - Management Options, 4th ed. Elsevier: Philadelphia, 2010, pp 521-42.

Yudin MH, Salaripour M, Sgro MD. Acceptability and feasibility of seasonal influenza vaccine administration in an antenatal clinic setting. J Obstet Gynaecol Can 2010 Aug;32(8):745-8.

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PEER-REVIEWED PUBLICATIONS 2011-2012 Original Research

A Countercurrents Series, Narod SA. A model for breast cancer risk based on stem-cell theory. Curr Oncol. 2012 Feb;19(1):9-11.

A Countercurrents Series, Narod SA. Disappearing breast cancers. Curr Oncol 2012 Apr;19(2):59-60.

Adams LA, Marsh JA, Ayonrinde OT, Olynyk JK, Ang WQ, Beilin LJ, Mori T, Palmer LJ, Oddy WW, Lye SJ, Pennell CE.Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity. J Gastroenterol Hepatol 2012 Mar 13. doi: 10.1111/j.1440- 1746.2012.07120.x. [Epub ahead of print]

Al Riyami N, Walker MG, Proctor LK, Yinon Y, Windrim RC, Kingdom JC. Utility of head/abdomen circumference ratio in the evaluation of severe early-onset intrauterine growth restriction. J Obstet Gynaecol Can 2011 Jul;33(7):715-9.

Alfaraj MA, Shah PS, Bohn D, Pantazi S, O'Brien K, Chiu PP, Gaiteiro R, Ryan G. Congenital diaphragmatic hernia: lung-to-head ratio and lung volume for prediction of outcome. Am J Obstet Gynecol 2011 Jul;205(1):43.e1-8. Epub 2011 Feb 23.

Allen VM, Yudin MH, Bouchard C, Boucher M, Caddy S, Castillo E, Money DM, Murphy KE, Ogilvie G, Paquet C, van Schalkwyk J, Senikas V; Infectious Diseases Committee, Society of Obstetricians and Gynaecologists of Canada. Management of group B streptococcal bacteriuria in pregnancy. J Obstet Gynaecol Can 2012 May;34(5):482-6.

Amsalem H, Kingdom JC, Farine D, Allen L, Yinon Y, D'Souza DL, Kachura J, Pantazi S, Windrim R. Planned caesarean hysterectomy versus "conserving" caesarean section in patients with placenta accreta. J Obstet Gynaecol Can 2011 Oct;33(10):1005-10.

Anderson BH, Kasher PR, Mayer J, Szynkiewicz M, Jenkinson EM, Bhaskar SS, Urquhart JE, Daly SB, Dickerson JE, O'Sullivan J, Leibundgut EO, Muter J, Abdel-Salem GM, Babul-Hirji R, Baxter P, Berger A, Bonafé L, Brunstom-Hernandez JE, Buckard JA, Chitayat D, Chong WK, Cordelli DM, Ferreira P, Fluss J, Forrest EH, Franzoni E, Garone C, Hammans SR, Houge G, Hughes I, Jacquemont S, Jeannet PY, Jefferson RJ, Kumar R, Kutschke G, Lundberg S, Lourenço CM, Mehta R, Naidu S, Nischal KK, Nunes L, Ounap K, Philippart M, Prabhakar P, Risen SR, Schiffmann R, Soh C, Stephenson JB, Stewart H, Stone J, Tolmie JL, van der Knaap MS, Vieira JP, Vilain CN, Wakeling EL, Wermenbol V, Whitney A, Lovell SC, Meyer S, Livingston JH, Baerlocher GM, Black GC, Rice GI, Crow YJ. Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus. Nat Genet 2012 Jan 22;44(3):338-42. doi: 10.1038/ng.1084.

PUBLICATIONS 2011-2012 82

Anderson NM, Berberovic Z, Berndl E, Bailey ML, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Wang C, Minden MD, McNagny KM, Paulson RF, Barber DL, Stanford WL. Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens.Exp Hematol 2012 Jan;40(1):48-60. Epub 2011 Sep 14.

Audette MC, Challis JR, Jones RL, Sibley CP, Matthews SG. Antenatal dexamethasone treatment in midgestation reduces system A-mediated transport in the late-gestation murine placenta. Endocrinology 2011 Sep;152(9):3561-70. Epub 2011 Jul 5. Bainbridge SA, Minhas A, Whiteley KJ, Qu D, Sled JG, Kingdom JC, Adamson SL.Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice. Hypertension 2012 Mar;59(3):732-9. Epub 2012 Jan 23.

Balki M, Kanwal N, Erik-Soussi M, Kingdom J, Carvalho JC. Contractile Efficacy of Various Prostaglandins in Pregnant Rat Myometrium Pretreated With Oxytocin. Reprod Sci 2012 Apr 26. [Epub ahead of print]

Barbera L, Fitch M, Adams L, Doyle C, Dasgupta T, Blake J. Improving care for women after gynecological cancer: the development of a sexuality clinic. Menopause 2011 Dec;18(12):1327-33. Review.

Barthson J, Germano CM, Moore F, Maida A, Drucker DJ, Marchetti P, Gysemans C, Mathieu C, Nuñez G, Jurisicova A, Eizirik DL, Gurzov EN. Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation. J Biol Chem 2011 Nov 11;286(45):39632-43. Epub 2011 Sep 21.

Bentov Y, Kenigsberg S, Casper RF. A novel luteinizing hormone/chorionic gonadotropin receptor mutation associated with amenorrhea, low oocyte yield, and recurrent pregnancy loss. Fertil Steril 2012 May;97(5):1165-8. Epub 2012 Feb 25.

Bentov Y, Yavorska T, Esfandiari N, Jurisicova A, Casper RF. The contribution of mitochondrial function to reproductive aging. J Assist Reprod Genet 2011 Sep;28(9):773-83. Epub 2011 May 27. Review.

Bhuiyan M, Petropoulos S, Gibb W, Matthews SG. Sertraline alters multidrug resistance phosphoglycoprotein activity in the mouse placenta and fetal blood-brain barrier. Reprod Sci 2012 Apr;19(4):407-15.

Blanchard-Rohner G, Meier S, Ryser J, Schaller D, Combescure C, Yudin MH, Burton-Jeangros C, de Tejada BM, Siegrist CA. Acceptability of maternal immunization against influenza: The critical role of obstetricians. J Matern Fetal Neonatal Med 2012 Mar 16. [Epub ahead of print]

Blanpain C, Daley GQ, Hochedlinger K, Passegué E, Rossant J, Yamanaka S. Stem cells assessed. Nat Rev Mol Cell Biol 2012 Jun 8;13(7):471-6. doi: 10.1038/nrm3371.

Borges L, Iacovino M, Mayerhofer T, Koyano-Nakagawa N, Baik J, Garry DJ, Kyba M, Letarte M, Perlingeiro RC. A critical role for endoglin in the emergence of blood during embryonic development. Blood 2012 Jun 7;119(23):5417-28. Epub 2012 Apr 24.

Borgoño CA, Hamilton JK, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R. Determinants of Insulin Resistance in Infants at Age 1 Year: Impact of gestational diabetes mellitus. Diabetes Care 2012 Jun 14. [Epub ahead of print] PUBLICATIONS 2011-2012 83

Bortolini MA, Shynlova O, Drutz HP, Castro RA, Girão MJ, Lye S, Alarab M. Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse. Neurourol Urodyn 2012 Jan;31(1):109-14. doi: 10.1002/nau.21175. Epub 2011 Oct 28.

Brown TJ, Sugie A, Leed MG, Widenhoefer RA. Structures and Dynamic Solution Behavior of Cationic, Two-Coordinate Gold(I)-π-Allene Complexes. Chemistry 2012 May 29;18(22):6959-71. doi: 10.1002/chem.201103289. Epub 2012 Apr 23. Brown TJ, Weber D, Gagné MR, Widenhoefer RA. Mechanistic Analysis of Gold(I)-Catalyzed Intramolecular Allene Hydroalkoxylation Reveals an Off-Cycle Bis(gold) Vinyl Species and Reversible C-O Bond Formation. J Am Chem Soc 2012 May 29. [Epub ahead of print]

Brun CR, Shoemaker JK, Bocking A, Hammond JA, Poole M, Mottola MF. Bed-rest exercise, activity restriction, and high-risk pregnancies: a feasibility study. Appl Physiol Nutr Metab 2011 Aug;36(4):577- 82. Epub 2011 Aug 19.

Carter MT, Blaser S, Papsin B, Meschino W, Reardon W, Klatt R, Babul-Hirji R, Milunsky J, Chitayat D. Middle and inner ear malformations in mutation-proven branchio-oculo-facial (BOF) syndrome: Case series and review of the literature. Am J Med Genet A 2012 Jun 18. doi: 10.1002/ajmg.a.35436. [Epub ahead of print]

Cabral WA, Barnes AM, Adeyemo A, Cushing K, Chitayat D, Porter FD, Panny SR, Gulamali-Majid F, Tishkoff SA, Rebbeck TR, Gueye SM, Bailey-Wilson JE, Brody LC, Rotimi CN, Marini JC. A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta. Genet Med 2012 May;14(5):543-51. doi: 10.1038/gim.2011.44. Epub 2012 Jan 26.

Casper RF. Detrimental effect of induced or spontaneous menses before ovulation induction on pregnancy outcome in patients with polycystic ovary syndrome. Obstet Gynecol 2012 May;119(5):886-7.

Casper RF. It's time to pay attention to the endometrium. Fertil Steril 2011 Sep;96(3):519-21.

Casper RF, Mitwally MF. Use of the aromatase inhibitor letrozole for ovulation induction in women with polycystic ovarian syndrome. Clin Obstet Gynecol 2011 Dec;54(4):685-95.

Chand D, Song L, Delannoy L, Barsyte-Lovejoy D, Ackloo S, Boutros PC, Evans K, Belsham DD, Lovejoy DA. C-terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A- mediated mechanism in hippocampal cells. Neuroscience 2012 Jun 12. [Epub ahead of print]

Chang KT, Keating S, Costa S, Machin G, Kingdom J, Shannon P. Third-trimester stillbirths: correlative neuropathology and placental pathology. Pediatr Dev Pathol 2011 Sep-Oct;14(5):345-52. Epub 2011 Feb 23.

Chau NG, Florescu A, Chan KK, Wang L, Chen EX, Bedard P, Oza AM, Siu LL. Early mortality and overall survival in oncology phase I trial participants: can we improve patient selection? BMC Cancer 2011 Oct 5;11:426.

PUBLICATIONS 2011-2012 84

Chitayat D, Langlois S, Wilson RD; Genetics Committee of the Society of Obstetricians and Gynaecologists of Canada; Prenatal Diagnosis Committee of the Canadian College of Medical Geneticists. Prenatal screening for fetal aneuploidy in singleton pregnancies. J Obstet Gynaecol Can 2011 Jul;33(7):736-50.

Chua SJ, Casper RF, Rogers IM. Toward transgene-free induced pluripotent stem cells: lessons from transdifferentiation studies. Cell Reprogram 2011 Aug;13(4):273-80. doi: 10.1089/cell.2010.0108. Epub 2011 May 20.

Chung BH, Fernandez B, Li C, Chitayat D. Correspondence: Further studies on a kindred reported by Li 2009 as 'A new syndrome of ankyloglossia and ulnar ray defects in Newfoundland kindred'. From 'new syndrome' through EEC to ulnar mammary syndrome. Clin Dysmorphol 2012 Apr;21(2):109-11.

Cina D, Onay T, Paltoo A, Li C, Maezawa Y, De Arteaga J, Jurisicova A, Quaggin S. Inhibition of MTOR disrupts autophagic flux in podocytes. Autophagy 2012 Apr 1;8(4). [Epub ahead of print]

Cinà DP, Onay T, Paltoo A, Li C, Maezawa Y, De Arteaga J, Jurisicova A, Quaggin SE. Inhibition of MTOR disrupts autophagic flux in podocytes. J Am Soc Nephrol 2012 Mar;23(3):412-20. Epub 2011 Dec 22.

Clark CA, Laskin CA, Spitzer KA. Anticardiolipin antibodies and recurrent early pregnancy loss: a century of equivocal evidence. Hum Reprod Update 2012 Jun 13. [Epub ahead of print]

Clark CA, Laskin CA, Spitzer KA. Obstetric antiphospholipid syndrome: conclusions confounded by small sample sizes and uncertain antibody profiles. J Matern Fetal Neonatal Med 2011 Nov 25. [Epub ahead of print]

Crudo A, Petropoulos S, Moisiadis VG, Iqbal M, Kostaki A, Machnes Z, Szyf M, Matthews SG. Prenatal synthetic glucocorticoid treatment changes DNA methylation States in male organ systems: multigenerational effects. Endocrinology 2012 Jul;153(7):3269-83. Epub 2012 May 7.

Covens AL, Dodge JE, Lacchetti C, Elit LM, Le T, Devries-Aboud M, Fung-Kee-Fung M; Gynecology Cancer Disease Site Group. Surgical management of a suspicious adnexal mass: A systematic review. Gynecol Oncol 2012 Apr 19. [Epub ahead of print]

Cox B, Sharma P, Evangelou AI, Whiteley K, Ignatchenko V, Ignatchenko A, Baczyk D, Czikk M, Kingdom J, Rossant J, Gramolini AO, Adamson SL, Kislinger T. Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia. Mol Cell Proteomics 2011 Dec;10(12):M111.012526. Epub 2011 Oct 10.

Crane J, Scott H, Stewart A, Chandra S, Whittle W, Hutchens D. Transvaginal ultrasonography to predict preterm birth in women with bicornuate or didelphus uterus. J Matern Fetal Neonatal Med. 2012 Apr 21 [Epub ahead of print]

Crowther CA, Aghajafari F, Askie LM, Asztalos EV, Brocklehurst P, Bubner TK, Doyle LW, Dutta S, Garite TJ, Guinn DA, Hallman M, Hannah ME, Hardy P, Maurel K, Mazumder P, McEvoy C, Middleton PF, Murphy KE, Peltoniemi OM, Peters D, Sullivan L, Thom EA, Voysey M, Wapner RJ, Yelland L, Zhang S. Repeat prenatal corticosteroid prior to preterm birth: a systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid international IPD study group: assessing the effects using the best level of evidence) - study protocol. Syst Rev 2012 Feb 12;1(1):12. PUBLICATIONS 2011-2012 85

Dalvi PS, Belsham DD. Glucagon-like peptide-2 directly regulates hypothalamic neurons expressing neuropeptides linked to appetite control in vivo and in vitro. Endocrinology 2012 May;153(5):2385-97. Epub 2012 Mar 13.

Dalvi PS, Erbiceanu FD, Irwin DM, Belsham DD. Direct Regulation of the Proglucagon Gene by Insulin, Leptin, and cAMP in Embryonic versus Adult Hypothalamic Neurons. Mol Endocrinol 2012 Jun 5. [Epub ahead of print]

Désilets V, Oligny LL; Genetics Committee of the Society of Obstetricians and Gynaecology Canada [Wolfman W]; Family Physicians Advisory Committee; Medico–Legal Committee of the SOGC. Fetal and perinatal autopsy in prenatally diagnosed fetal abnormalities with normal karyotype. J Obstet Gynaecol Can 2011 Oct;33(10):1047-57. Review.

Dhillon SS, Gingerich S, Virtanen C, Belsham DD.Gene array analysis of embryonic- versus adult- derived hypothalamic NPY-expressing cell lines. Mol Cell Endocrinol 2012 Jul 6;358(1):116-26. Epub 2012 Mar 28.

Dhillon SS, McFadden SA, Chalmers JA, Centeno ML, Kim GL, Belsham DD. Cellular leptin resistance impairs the leptin-mediated suppression of neuropeptide Y secretion in hypothalamic neurons. Endocrinology 2011 Nov;152(11):4138-47. Epub 2011 Sep 13.

Diamond P, Hassonah S, Alarab M, Lovatsis D, Drutz HP.The prevalence of detrusor overactivity amongst patients with symptoms of overactive bladder: a retrospective cohort study. Int Urogynecol J 2012 Apr 25. [Epub ahead of print]

Diamond MP, Mitwally M, Casper R, Ager J, Legro RS, Brzyski R, Casson P, Eisenberg E, Zhang H; NICHD Cooperative Reproductive Medicine Network. Estimating rates of multiple gestation pregnancies: sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial. Contemp Clin Trials 2011 Nov;32(6):902-8. Epub 2011 Jul 20.

Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, Mobbs CV, Yang X, Gao XB, Horvath TL. Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nat Med 2011 Aug 28;17(9):1121-7. doi: 10.1038/nm.2421. Erratum in: Nat Med. 2011 Oct;17(10):1320.

Diaz-Padilla I, Duran I, Clarke BA, Oza AM. Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer. Cancer Treat Rev 2012 Oct;38(6):767-75. Epub 2012 Feb 29.

Ding YC, McGuffog L, Healey S, … Narod SA, …Neuhausen SL. A non-synonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2012 Jun 26. [Epub ahead of print]

Dodds M, Windrim R, Kingdom J. Complex umbilical cord entanglement. J Matern Fetal Neonatal Med 2012 Apr 25. [Epub ahead of print]

Dodge JE, Covens AL, Lacchetti C, Elit LM, Le T, Devries-Aboud M, Fung-Kee-Fung M; The Gynecology Cancer Disease Site Group. Preoperative identification of a suspicious adnexal mass: A systematic review and meta-analysis. Gynecol Oncol 2012 Apr 6. [Epub ahead of print]

PUBLICATIONS 2011-2012 86

Drewlo S, Levytska K, Sobel M, Baczyk D, Lye SJ, Kingdom JC. Heparin promotes soluble VEGF receptor expression in human placental villi to impair endothelial VEGF signaling. J Thromb Haemost 2011 Dec;9(12):2486-97. doi: 10.1111/j.1538-7836.2011.04526.x.

Drutz HP. Overactive bladder: the importance of tailoring treatment to the individual patient. J Multidiscip Healthc 2011;4:233-7. Epub 2011 Jul 22.

Duncan A, Langlois S; SOGC Genetics Committee; CCMG Prenatal Diagnosis Committee [Chitayat D]. Use of array genomic hybridization technology in prenatal diagnosis in Canada. J Obstet Gynaecol Can 2011 Dec;33(12):1256-9.

Dunk CE, Gellhaus A, Drewlo S, Baczyk D, Pötgens AJ, Winterhager E, Kingdom JC, Lye SJ. The molecular role of connexin 43 in human trophoblast cell fusion. Biol Reprod 2012 Apr 19;86(4):115. Print 2012 Apr.

Dunk CE, Roggensack AM, Cox B, Perkins JE, Asenius F, Keating S, Weksberg R, Kingdom JC, Adamson SL. A distinct microvascular endothelial gene expression profile in severe IUGR placentas. Placenta 2012 Apr;33(4):285-93. Epub 2012 Jan 20.

Eiriksson LR, Covens A. Follow-up after chemoradiation for cervical cancer: Why? Cancer 2011 Sep 1;117(17):3875-8. doi: 10.1002/cncr.25990. Epub 2011 Mar 8.

Eiriksson LR, Covens A. Sentinel lymph node mapping in cervical cancer: the future? BJOG 2012 Jan;119(2):129-33. doi: 10.1111/j.1471-0528.2011.03134.x. Epub 2011 Sep 14.

Emack J, Matthews SG. Effects of chronic maternal stress on hypothalamo-pituitary-adrenal (HPA) function and behavior: no reversal by environmental enrichment. Horm Behav 2011 Nov;60(5):589-98. Epub 2011 Aug 31.

Fanning N, Balki M, Sermer M, Colman J, Carvalho JC. Noninvasive cardiac output monitoring during general anesthesia for Cesarean delivery in a patient with severe aortic stenosis. Can J Anaesth 2011 Sep;58(9):837-41. Epub 2011 Jun 18.

Fernandes R, Tsuda C, Perumalsamy AL, Naranian T, Chong J, Acton BM, Tong ZB, Nelson LM, Jurisicova A. NLRP5 mediates mitochondrial function in mouse oocytes and embryos. Biol Reprod 2012 May 3;86(5):138, 1-10. Print 2012.

Fick LJ, Fick GH, Belsham DD. Palmitate alters the rhythmic expression of molecular clock genes and orexigenic neuropeptide Y mRNA levels within immortalized, hypothalamic neurons. Biochem Biophys Res Commun 2011 Sep 30;413(3):414-9. Epub 2011 Aug 27.

Finkelman BS, Rubinstein WS, Friedman S, Friebel TM, Dubitsky S, Schonberger NS, Shoretz R, Singer CF, Blum JL, Tung N, Olopade OI, Weitzel JN, Lynch HT, Snyder C, Garber JE, Schildkraut J, Daly MB, Isaacs C, Pichert G, Neuhausen SL, Couch FJ, van't Veer L, Eeles R, Bancroft E, Evans DG, Ganz PA, Tomlinson GE, Narod SA, Matloff E, Domchek S, Rebbeck TR. Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers. J Clin Oncol 2012 Apr 20;30(12):1321-8. Epub 2012 Mar 19.

Firestone RS, Esfandiari N, Moskovtsev SI, Burstein E, Videna GT, Librach C, Bentov Y, Casper RF. The effects of low-level laser light exposure on sperm motion characteristics and DNA damage. J Androl 2012 May;33(3):469-73. Epub 2011 Jul 14. PUBLICATIONS 2011-2012 87

Fitzgerald B, Shannon P, Kingdom J, Keating S. Basal plate plaque: A novel organising placental thrombotic process. J Clin Pathol 2011 Aug;64(8):725-8. Epub 2011 Jan 20.

Fitzgerald B, Shannon P, Kingdom J, Keating S. Rounded intraplacental haematomas due to decidual vasculopathy have a distinctive morphology. J Clin Pathol 2011 Aug;64(8):729-32. Epub 2011 Mar 1.

Fong KW, Toi A, Okun N, Al-Shami E, Menezes RJ. Retrospective review of diagnostic performance of intracranial translucency in detection of open spina bifida at the 11-13-week scan. Ultrasound Obstet Gynecol 2011 Dec;38(6):630-4. doi: 10.1002/uog.8994. Epub 2011 Nov 11.

Gardiner K, Chitayat D, Choufani S, Shuman C, Blaser S, Terespolsky D, Farrell S, Reiss R, Wodak S, Pu S, Ray PN, Baskin B, Weksberg R. Brain abnormalities in patients with Beckwith-Wiedemann syndrome. Am J Med Genet A 2012 Jun;158A(6):1388-94. doi: 10.1002/ajmg.a.35358. Epub 2012 May 14.

George SH, Greenaway J, Milea A, Clary V, Shaw S, Sharma M, Virtanen C, Shaw PA. Identification of abrogated pathways in fallopian tube epithelium from BRCA1 mutation carriers. J Pathol 2011 Sep;225(1):106-17. doi: 10.1002/path.2927. Epub 2011 Jul 8.

Gibson WT, Hood RL, Zhan SH, Bulman DE, Fejes AP, Moore R, Mungall AJ, Eydoux P, Babul-Hirji R, An J, Marra MA; FORGE Canada Consortium, Chitayat D, Boycott KM, Weaver DD, Jones SJ. Mutations in EZH2 cause Weaver syndrome. Am J Hum Genet 2012 Jan 13;90(1):110-8. Epub 2011 Dec 15.

Gillis J, Burashnikov E, Antzelevitch C, Blaser S, Gross G, Turner L, Babul-Hirji R, Chitayat D. Long QT, syndactyly, joint contractures, stroke and novel CACNA1C mutation: Expanding the spectrum of Timothy syndrome. Am J Med Genet A 2011 Nov 21. doi: 10.1002/ajmg.a.34355. [Epub ahead of print]

Goh ES, Perez IC, Canales CP, Ruiz P, Agatep R, Yoon G, Chitayat D, Dror Y, Shago M, Goobie S, Sgro M, Walz K, Mendoza-Londono R. Definition of a critical genetic interval related to kidney abnormalities in the Potocki-Lupski syndrome. Am J Med Genet A 2012 Jul;158A(7):1579-88. doi: 10.1002/ajmg.a.35399. Epub 2012 May 25.

Gomes MC, Kotsopoulos J, de Almeida GL, Costa MM, Vieira R, Filho Fde A, Pitombo MB, F Leal PR, Royer R, Zhang P, Narod SA. The R337H mutation in TP53 and breast cancer in Brazil. Hered Cancer Clin Pract 2012 Mar 28;10(1):3.

Gracie S, Pennell C, Ekman-Ordeberg G, Lye S, McManaman J, Williams S, Palmer L, Kelley M, Menon R, Gravett M; PREBIC "-Omics" Research Group. An integrated systems biology approach to the study of preterm birth using "-omic" technology--a guideline for research. BMC Pregnancy Childbirth 2011 Oct 12;11:71. Review.

Greenaway JB, Koehler A, McCulloch CA, Petrik J, Brown TJ, Ringuette MJ. The impact of the ovarian microenvironment on the anti-tumor effect of SPARC on ovarian cancer. Biochem Cell Biol 2012 Feb;90(1):96-107. Epub 2011 Oct 17.

PUBLICATIONS 2011-2012 88

Gribouval O, Morinière V, Pawtowski A, Arrondel C, Sallinen SL, Saloranta C, Clericuzio C, Viot G, Tantau J, Blesson S, Cloarec S, Machet MC, Chitayat D, Thauvin C, Laurent N, Sampson JR, Bernstein JA, Clemenson A, Prieur F, Daniel L, Levy-Mozziconacci A, Lachlan K, Alessandri JL, Cartault F, Rivière JP, Picard N, Baumann C, Delezoide AL, Belar Ortega M, Chassaing N, Labrune P, Yu S, Firth H, Wellesley D, Bitzan M, Alfares A, Braverman N, Krogh L, Tolmie J, Gaspar H, Doray B, Majore S, Bonneau D, Triau S, Loirat C, David A, Bartholdi D, Peleg A, Brackman D, Stone R, DeBerardinis R, Corvol P, Michaud A, Antignac C, Gubler MC. Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis. Hum Mutat 2012 Feb;33(2):316-26. doi: 10.1002/humu.21661. Epub 2011 Dec 22. Review.

Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med 2012 Jan 16;209(1):173-86. Epub 2012 Jan 2.

Hakem A, El Ghamrasni S, Maire G, Lemmers B, Karaskova J, Jurisicova A, Sanchez O, Squire J, Hakem R. Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis. Blood 2012 Apr 12;119(15):3495-502. Epub 2012 Feb 16.

Hamilton S, Oomomian Y, Stephen G, Shynlova O, Tower CL, Garrod A, Lye SJ, Jones RL. Macrophages infiltrate the human and rat decidua during term and preterm labor: evidence that decidual inflammation precedes labor. Biol Reprod 2012 Feb 14;86(2):39. Print 2012 Feb.

Hatton R, Colman JM, Sermer M, Grewal J, Silversides CK. Cardiac risks and management of complications in pregnant women with congenital heart disease. Future Cardiol 2012 Mar;8(2):315-27.

Helpman L, Grisaru D, Covens A. Early adenocarcinoma of the cervix: is radical vaginal trachelectomy safe? Gynecol Oncol 2011 Oct;123(1):95-8. Epub 2011 Jul 20.

Hladunewich MA, Kingdom J, Odutayo A, Burns K, Lai V, O'Brien T, Gandhi S, Zimpelmann J, Kiss A, Miller J, Cherney D. Postpartum assessment of the renin angiotensin system in women with previous severe, early-onset preeclampsia. J Clin Endocrinol Metab 2011 Nov;96(11):3517-24. Epub 2011 Aug 31.

Hodes-Wertz B, Grifo J, Ghadir S, Kaplan B, Laskin CA, Glassner M, Munné S. Idiopathic recurrent miscarriage is caused mostly by aneuploid embryos. Fertil Steril 2012 Jun 7. [Epub ahead of print]

Hui D, Morrison LJ, Windrim R, Lausman AY, Hawryluck L, Dorian P, Lapinsky SE, Halpern SH, Campbell DM, Hawkins P, Wax RS, Carvalho JC, Dainty KN, Maxwell C, Jeejeebhoy FM. The American Heart Association 2010 guidelines for the management of cardiac arrest in pregnancy: consensus recommendations on implementation strategies. J Obstet Gynaecol Can 2011 Aug;33(8):858- 63. No abstract available.

Hui D, Okun N, Murphy K, Kingdom J, Uleryk E, Shah PS. Combinations of maternal serum markers to predict preeclampsia, small for gestational age, and stillbirth: a systematic review. J Obstet Gynaecol Can 2012 Feb;34(2):142-53. Review.

Iqbal J, Narod SA. Choices for young women at intermediate risk of breast cancer. Curr Oncol 2012 Jun;19(3):e112-4. PUBLICATIONS 2011-2012 89

International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol 2011 Nov 27;29(12):1132-44. doi: 10.1038/nbt.2051.

Iqbal J, Narod SA. Choices for young women at intermediate risk of breast cancer. Curr Oncol 2012 Jun;19(3):e112-4.

Iqbal M, Moisiadis VG, Kostaki A, Matthews SG.Transgenerational effects of prenatal synthetic glucocorticoids on hypothalamic-pituitary-adrenal function. Endocrinology 2012 Jul;153(7):3295-307. Epub 2012 May 7.

Iqbal M, Audette MC, Petropoulos S, Gibb W, Matthews SG. Placental drug transporters and their role in fetal protection. Placenta 2012 Mar;33(3):137-42. Epub 2012 Jan 20. Review.

Jaeggi ET, Carvalho JS, De Groot E, Api O, Clur SA, Rammeloo L, McCrindle BW, Ryan G, Manlhiot C, Blom NA. Comparison of transplacental treatment of fetal supraventricular tachyarrhythmias with digoxin, flecainide, and sotalol: results of a nonrandomized multicenter study. Circulation 2011 Oct 18;124(16):1747-54. Epub 2011 Sep 19.

Jeejeebhoy FM, Zelop CM, Windrim R, Carvalho JC, Dorian P, Morrison LJ. Management of cardiac arrest in pregnancy: A systematic review. Resuscitation 2011 Jul;82(7):801-9. Epub 2011 May 6. Review.

Jerkic M, Kabir MG, Davies A, Yu LX, McIntyre BA, Husain NW, Enomoto M, Sotov V, Husain M, Henkelman M, Belik J, Letarte M. Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress. Cardiovasc Res 2011 Dec 1;92(3):375-84. Epub 2011 Aug 22.

Kapur NK, Wilson S, Yunis AA, Qiao X, Mackey E, Paruchuri V, Baker C, Aronovitz MJ, Karumanchi SA, Letarte M, Kass DA, Mendelsohn ME, Karas RH. Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure. Circulation 2012 Jun 5;125(22):2728-38. Epub 2012 May 16.

Karlan BY, Oza AM, Richardson GE, Provencher DM, Hansen VL, Buck M, Chambers SK, Ghatage P, Pippitt CH Jr, Brown JV 3rd, Covens A, Nagarkar RV, Davy M, Leath CA 3rd, Nguyen H, Stepan DE, Weinreich DM, Tassoudji M, Sun YN, Vergote IB. Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer. J Clin Oncol 2012 Feb 1;30(4):362-71. Epub 2011 Dec 19.

PUBLICATIONS 2011-2012 90

Kenna K, De Matteo R, Hanita T, Rees S, Sozo F, Stokes V, Walker D, Bocking A, Brien J, Harding R. Daily ethanol exposure during late ovine pregnancy: physiological effects in the mother and fetus in the apparent absence of overt fetal cerebral dysmorphology. Am J Physiol Regul Integr Comp Physiol 2011 Oct;301(4):R926-36. Epub 2011 Jun 29.

Kew S, Ye C, Sermer M, Connelly PW, Hanley AJ, Zinman B, Retnakaran R. Postpartum metabolic function in women delivering a macrosomic infant in the absence of gestational diabetes mellitus. Diabetes Care 2011 Dec;34(12):2608-13. Epub 2011 Oct 4.

Kim GL, Wang X, Chalmers JA, Thompson DR, Dhillon SS, Koletar MM, Belsham DD.Generation of immortal cell lines from the adult pituitary: role of cAMP on differentiation of SOX2-expressing progenitor cells to mature gonadotropes. PLoS One 2011;6(11):e27799. Epub 2011 Nov 21.

Kimberly L, Case A, Cheung AP, Sierra S, AlAsiri S, Carranza-Mamane B, Case A, Dwyer C, Graham J, Havelock J, Hemmings R, Lee F, Liu K, Murdock W, Senikas V, Vause TD, Wong BC. Advanced reproductive age and fertility: no. 269, November 2011. Int J Gynaecol Obstet 2012 Apr;117(1):95-102.

Kingdom JC, Baud D, Grabowska K, Thomas J, Windrim RC, Maxwell CV. Delivery by Caesarean section in super-obese women: Beyond Pfannenstiel. J Obstet Gynaecol Can 2012 May;34(5):472-4. No abstract available.

Kingdom JC, Drewlo S. Is heparin a placental anticoagulant in high-risk pregnancies? Blood 2011 Nov 3;118(18):4780-8. Epub 2011 Aug 25. Review.

Kingdom JC, Walker M, Proctor LK, Keating S, Shah PS, McLeod A, Keunen J, Windrim RC, Dodd JM. Unfractionated heparin for second trimester placental insufficiency: a pilot randomized trial. J Thromb Haemost 2011 Aug;9(8):1483-92. doi: 10.1111/j.1538-7836.2011.04407.x.

Kollara A, Brown TJ. Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity. Cell Mol Life Sci 2012 May 5. [Epub ahead of print]

Kollara A, Ringuette MJ, Brown TJ. Dynamic distribution of nuclear coactivator 4 during mitosis: association with mitotic apparatus and midbodies. PLoS One 2011;6(7):e22257. Epub 2011 Jul 26.

Kotsopoulos J, Lubinski J, Lynch HT, Kim-Sing C, Neuhausen S, Demsky R, Foulkes WD, Ghadirian P, Tung N, Ainsworth P, Senter L, Karlan B, Eisen A, Eng C, Weitzel J, Gilchrist DM, Blum JL, Zakalik D, Singer C, Fallen T, Ginsburg O, Huzarski T, Sun P, Narod SA. Oophorectomy after Menopause and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers. Cancer Epidemiol Biomarkers Prev 2012 May 21. [Epub ahead of print]

Kotsopoulos J, Lubinski J, Salmena L, Lynch HT, Kim-Sing C, Foulkes WD, Ghadirian P, Neuhausen SL, Demsky R, Tung N, Ainsworth P, Senter L, Eisen A, Eng C, Singer C, Ginsburg O, Blum J, Huzarski T, Poll A, Sun P, Narod SA; the Hereditary Breast Cancer Clinical Study Group. Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 2012 Mar 9;14(2):R42. [Epub ahead of print]

Kotsopoulos J, Moody JR, Fan I, Rosen B, Risch HA, McLaughlin JR, Sun P, Narod SA. Height, weight, BMI and ovarian cancer survival. Gynecol Oncol 2012 Jun 16. [Epub ahead of print]

PUBLICATIONS 2011-2012 91

Kotsopoulos J, Sukiennicki G, Muszyńska M, Gackowski D, Kąklewski K, Durda K, Jaworska K, Huzarski T, Gronwald J, Byrski T, Ashuryk O, Dębniak T, Tołoczko-Grabarek A, Stawicka M, Godlewski D, Oliński R, Jakubowska A, Narod SA, Lubinski J. Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study. Cancer Causes Control 2012 Jul;23(7):1065-74. Epub 2012 May 11.

Kroft J, Shier M. A novel approach to the surgical management of clitoral phimosis. J Obstet Gynaecol Can 2012 May;34(5):465-71.

Kulandavelu S, Whiteley KJ, Qu D, Mu J, Bainbridge SA, Adamson SL. Endothelial nitric oxide synthase deficiency reduces uterine blood flow, spiral artery elongation, and placental oxygenation in pregnant mice. Hypertension 2012 Jul;60(1):231-8. Epub 2012 May 21.

Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ. Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. J Clin Invest 2012 Jan 3;122(1):388-402. doi: 10.1172/JCI42497. Epub 2011 Dec 19.

Laskin M, Yinon Y, Whittle WL. Preterm premature rupture of membranes in the presence of cerclage: is the risk for intra-uterine infection and adverse neonatal outcome increased? J Matern Fetal Neonatal Med 2012 Apr;25(4):424-8.

Lausman A, McCarthy FP, Walker M, Kingdom J. Screening, diagnosis, and management of intrauterine growth restriction. J Obstet Gynaecol Can 2012 Jan;34(1):17-28. Li J, McCormick J, Bocking A, Reid G. Importance of vaginal microbes in reproductive health. Reprod Sci 2012 Mar;19(3):235-42.

Lee FY, Faivre EJ, Suzawa M, Lontok E, Ebert D, Cai F, Belsham DD, Ingraham HA. Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell 2011 Aug 16;21(2):315-27. Epub 2011 Aug 4.

Ley SH, Hanley AJ, Retnakaran R, Sermer M, Zinman B, O'Connor DL. Effect of macronutrient intake during the second trimester on glucose metabolism later in pregnancy. Am J Clin Nutr 2011 Nov;94(5):1232-40. Epub 2011 Sep 28.

Ley SH, Hanley AJ, Sermer M, Zinman B, O'Connor DL Associations of prenatal metabolic abnormalities with insulin and adiponectin concentrations in human milk. Am J Clin Nutr 2012 Apr;95(4):867-74. Epub 2012 Feb 29.

Liu EL, Greenblatt EM. Oocyte Cryopreservation in Canada: A survey of Canadian ART Clinics. J Obstet Gynaecol Can 2012 Mar;34(3):250-6.

Liu K, Case A. Advanced Reproductive Age and Fertility. SOGC Clinical Practice Guideline No. 269. JOGC 2011;33(11):1165-75.

Liu K, Greenblatt E. Ovarian hyperstimulation syndrome. In: Griffith’s: 5-Minute Clinical Consult. Frank J. Domino, editor. Lippincott, Williams and Wilkins: Philadelphia. 2012.

Liu KE, Alhajri M, Greenblatt E. A randomized controlled trial of NuvaRing versus combined oral contraceptive pills for pretreatment in in vitro fertilization cycles. Fertil Steril 2011 Sep;96(3):605-8.

PUBLICATIONS 2011-2012 92

Liu L, Xie N, Rennie P, Challis JR, Gleave M, Lye SJ, Dong X. Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF. Mol Endocrinol 2011 Jul;25(7):1197-210. Epub 2011 May 12.

Loutfy MR, Margolese S, Money DM, Gysler M, Hamilton S, Yudin MH. Canadian HIV Pregnancy Planning Guidelines. J Obstet Gynaecol Can 2012 Jun;34(6):575-90.

Loutfy M, Raboud J, Wong J, Yudin M, Diong C, Blitz S, Margolese S, Hart T, Ogilvie G, Masinde K, Tharao W, Linklater G, Salam K, Ongoiba F, Angel J, Smaill F, Rachlis A, Ralph E, Walmsley S; Ontario HIV Fertility Research Team. High prevalence of unintended pregnancies in HIV-positive women of reproductive age in Ontario, Canada: a retrospective study. HIV Med 2012 Feb;13(2):107-17. doi: 10.1111/j.1468-1293.2011.00946.x. Epub 2011 Nov 21.

Lu Z, Zhang X, Leung C, Esfandiari N, Casper RF, Sun Y. Robotic ICSI (intracytoplasmic sperm injection). IEEE Trans Biomed Eng 2011 Jul;58(7):2102-8. Epub 2011 Apr 25.

Luo L, Ye G, Nadeem L, Fu G, Yang BB, Dunk C, Lye S, Peng C. MicroRNA-378a-5p promotes trophoblast cell survival, migration and invasion by targeting Nodal. J Cell Sci 2012 Mar 27. [Epub ahead of print]

Mackay HJ, Buckanovich RJ, Hirte H, Correa R, Hoskins P, Biagi J, Martin LP, Fleming GF, Morgan R, Wang L, Polintan R, Oza AM. A phase II study single agent of aflibercept (VEGF Trap) in patients with recurrent or metastatic gynecologic carcinosarcomas and uterine leiomyosarcoma. A trial of the Princess Margaret Hospital, Chicago and California Cancer Phase II Consortia. Gynecol Oncol 2012 Apr;125(1):136-40. Epub 2011 Dec 2.

Malinowski AK, McGeer A, Robertson J, Sermer M, Farine D, Lapinsky SE, Maxwell C. H1N1 in pregnancy: a tertiary care centre experience. J Obstet Gynaecol Can 2011 Jul;33(7):698-704.

Malvasi A, Stark M, Ghi T, Farine D, Guido M, Tinelli A. Intrapartum sonography for fetal head asynclitism and transverse position: sonographic signs and comparison of diagnostic performance between transvaginal and digital examination. J Matern Fetal Neonatal Med 2012 May;25(5):508-12. Epub 2012 Feb 14.

Mark S, Murphy KE, Read S, Bitnun A, Yudin MH. HIV Mother-to-Child Transmission, Mode of Delivery, and Duration of Rupture of Membranes: Experience in the Current Era. Infect Dis Obstet Gynecol 2012;2012:267969. Epub 2012 May 28.

Matthews SG, Phillips DI. Transgenerational inheritance of stress pathology. Exp Neurol 2012 Jan;233(1):95-101. Epub 2011 Jan 31. Review.

McCann MR, Tamplin OJ, Rossant J, Séguin CA. Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development.Dis Model Mech 2012 Jan;5(1):73-82. Epub 2011 Oct 25.

PUBLICATIONS 2011-2012 93

McCarthy FP, Drewlo S, English FA, Kingdom J, Johns EJ, Kenny LC, Walsh SK. Evidence implicating peroxisome proliferator-activated receptor-γ in the pathogenesis of preeclampsia. Hypertension 2011 Nov;58(5):882-7. Epub 2011 Sep 19.

McCarthy FP, Drewlo S, Kingdom J, Johns EJ, Walsh SK, Kenny LC. Peroxisome proliferator-activated receptor-γ as a potential therapeutic target in the treatment of preeclampsia. Hypertension 2011 Aug;58(2):280-6. Epub 2011 Jun 20.

Mendoza-Londono R, Chitayat D, Kahr WH, Hinek A, Blaser S, Dupuis L, Goh E, Badilla-Porras R, Howard A, Mittaz L, Superti-Furga A, Unger S, Nishimura G, Bonafe L. Extracellular matrix and platelet function in patients with musculocontractural Ehlers-Danlos syndrome caused by mutations in the CHST14 gene. Am J Med Genet A 2012 Jun;158A(6):1344-54. doi: 10.1002/ajmg.a.35339. Epub 2012 May 11.

Menzies R, Wallace S, Ennis M, Bennett A, Jacobson M, Yip G, Wolfman W. Significance of abnormal sonographic findings in postmenopausal women with and without bleeding. J Obstet Gynaecol Can 2011 Sep;33(9):944-51.

Merrill AE, Sarukhanov A, Krejci P, Idoni B, Camacho N, Estrada KD, Lyons KM, Deixler H, Robinson H, Chitayat D, Curry CJ, Lachman RS, Wilcox WR, Krakow D. Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling.Am J Hum Genet 2012 Mar 9;90(3):550- 7. Epub 2012 Mar 1.

Mileva-Seitz V, Fleming AS, Meaney MJ, Mastroianni A, Sinnwell JP, Steiner M, Atkinson L, Levitan RD, Matthews SG, Kennedy JL, Sokolowski MB. Dopamine receptors D1 and D2 are related to observed maternal behavior. Genes Brain Behav 2012 May 11. doi: 10.1111/j.1601-183X.2012.00804.x. [Epub ahead of print]

Miranda V, Alarab M, Murphy K, Pineda R, Drutz H, Lovatsis D. Randomized controlled trial of cystocele plication risks: a pilot study. J Obstet Gynaecol Can 2011 Nov;33(11):1146-9.

Moalem S, Babul-Hirji R, Stavropolous DJ, Wherrett D, Bägli DJ, Thomas P, Chitayat D. XX male sex reversal with genital abnormalities associated with a de novo SOX3 gene duplication. Am J Med Genet A. 2012 Jul;158A(7):1759-64. doi: 10.1002/ajmg.a.35390. Epub 2012 Jun 7.

Mousa NA, Eiada R, Crystal P, Nayot D, Casper RF. The effect of acute aromatase inhibition on breast parenchymal enhancement in magnetic resonance imaging: a prospective pilot clinical trial. Menopause 2012 Apr;19(4):420-5.

Murji A, Proctor LK, Paterson AD, Chitayat D, Weksberg R, Kingdom J. Male sex bias in placental dysfunction. Am J Med Genet A 2012 Apr;158A(4):779-83. doi: 10.1002/ajmg.a.35250. Epub 2012 Mar 9.

Murji A, Sobel ML, Hasan L, McLeod A, Waye JS, Sermer M, Berger H. Pregnancy outcomes in women with elevated levels of fetal hemoglobin. J Matern Fetal Neonatal Med 2012 Feb;25(2):125-9. Epub 2011 Apr 7.

Murphy J, Kennedy EB, Dunn S, McLachlin CM, Fung Kee Fung M, Gzik D, Shier M, Paszat L. Cervical screening: a guideline for clinical practice in Ontario. J Obstet Gynaecol Can 2012 May;34(5):453-8.

PUBLICATIONS 2011-2012 94

Murphy J, Kennedy EB, Dunn S, McLachlin CM, Fung Kee Fung M, Gzik D, Shier M, Paszat L. HPV testing in primary cervical screening: a systematic review and meta-analysis. J Obstet Gynaecol Can 2012 May;34(5):443-52.

Murphy KE, Hannah ME, Willan AR, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Tomat L, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA; MACS Collaborative Group.Maternal side-effects after multiple courses of antenatal corticosteroids (MACS): the three-month follow-up of women in the randomized controlled trial of MACS for preterm birth study. J Obstet Gynaecol Can 2011 Sep;33(9):909-21.

Murphy KE, Willan AR, Hannah ME, Ohlsson A, Kelly EN, Matthews SG, Saigal S, Asztalos E, Ross S, Delisle MF, Amankwah K, Guselle P, Gafni A, Lee SK, Armson BA; Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study Collaborative Group. Effect of antenatal corticosteroids on fetal growth and gestational age at birth. Obstet Gynecol 2012 May;119(5):917-23.

Myatt L, Eschenbach DA, Lye SJ, Mesiano S, Murtha AP, Williams SM, Pennell CE; International Preterm Birth Collaborative Pathways and Systems Biology Working Groups. A standardized template for clinical studies in preterm birth. Reprod Sci 2012 May;19(5):474-82. Epub 2012 Feb 16.

Nam RK, Herschorn S, Loblaw DA, Liu Y, Klotz LH, Carr LK, Kodama RT, Stanimirovic A, Venkateswaran V, Saskin R, Law CH, Urbach DR, Narod SA. Population Based Study of Long-Term Rates of Surgery for Urinary Incontinence After Radical Prostatectomy for Prostate Cancer. J Urol 2012 Jun 13. [Epub ahead of print]

Narod SA. Breast cancer in young women. Nat Rev Clin Oncol 2012 Jun 26. doi: 10.1038/nrclinonc.2012.102. [Epub ahead of print]

Narod SA. The tip of the iceberg: A Countercurrents Series. Curr Oncol 2012 Jun;19(3):129-30.

Narod S, Moody J, Rosen B, Fan I, Risch A, Sun P, McLaughlin J. Estimating survival rates after ovarian cancer among women tested for BRCA1 and BRCA2 mutations. Clin Genet 2012 Jun 8;9999(9999). doi: 10.1111/j.1399-0004.2012.01906.x. [Epub ahead of print]

Narod SA, Valentini A, Nofech-Mozes S, Sun P, Hanna W. Tumour characteristics among women with very low-risk breast cancer. Breast Cancer Res Treat 2012 May 1. [Epub ahead of print]

Ng T, Chand D, Song L, Al Chawaf A, Watson JD, Boutros PC, Belsham DD, Lovejoy DA. Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells. Regul Pept 2012 Feb 10;174(1-3):79-89. Epub 2011 Dec 30.

Nofech-Mozes S, Ismiil N, Dubé V, Saad RS, Ghorab Z, Grin A, Ackerman I, Khalifa MA. Interobserver agreement for endometrial cancer characteristics evaluated on biopsy material. Obstet Gynecol Int 2012;2012:414086. Epub 2012 Feb 2.

Ochotny N, Flenniken AM, Owen C, Voronov I, Zirngibl RA, Osborne LR, Henderson JE, Adamson SL, Rossant J, Manolson MF, Aubin JE. The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice. J Bone Miner Res 2011 Jul;26(7):1484-93. doi: 10.100 PUBLICATIONS 2011-2012 95

Osei-Kumah A, Smith R, Jurisica I, Caniggia I, Clifton VL. Sex-specific differences in placental global gene expression in pregnancies complicated by asthma. Placenta 2011 Aug;32(8):570-8. Epub 2011 Jun 8.

Oza AM, Castonguay V, Tsoref D, Diaz-Padilla I, Karakasis K, Mackay H, Welch S, Weberpals J, Hoskins P, Plante M, Provencher D, Tonkin K, Covens A, Ghatage P, Gregoire J, Hirte H, Miller D, Rosen B, Maroun J, Buyse M, Coens C, Brady MF, Stuart GC. Progression-free survival in advanced ovarian cancer: a Canadian review and expert panel perspective. Curr Oncol 2011 Oct;18 Suppl 2:S20-7.

Oza AM, Elit L, Tsao MS, Kamel-Reid S, Biagi J, Provencher DM, Gotlieb WH, Hoskins PJ, Ghatage P, Tonkin KS, Mackay HJ, Mazurka J, Sederias J, Ivy P, Dancey JE, Eisenhauer EA. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group. J Clin Oncol 2011 Aug 20;29(24):3278-85. Epub 2011 Jul 25.

Paca A, Séguin CA, Clements M, Ryczko M, Rossant J, Rodriguez TA, Kunath T. BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm. Dev Biol 2012 Jan 1;361(1):90-102. Epub 2011 Oct 14.

Papanna R, Habli M, Baschat AA, Bebbington M, Mann LK, Johnson A, Ryan G, Walker M, Lewis D, Harman C, Crombleholme T, Moise KJ Jr. Cerclage for cervical shortening at fetoscopic laser photocoagulation in twin-twin transfusion syndrome. Am J Obstet Gynecol 2012 May;206(5):425.e1-7. Epub 2012 Feb 28.

Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin JF, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TJ, Markovic A, Devereux WL, Ocasio CA, Chen JK, Stearns T, Thomas RK, Dorsch M, Buonamici S, Watkins DN, Peacock CD, Sage J. A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med 2011 Oct 9;17(11):1504-8. doi: 10.1038/nm.2473.

Passaperuma K, Warner E, Causer PA, Hill KA, Messner S, Wong JW, Jong RA, Wright FC, Yaffe MJ, Ramsay EA, Balasingham S, Verity L, Eisen A, Curpen B, Shumak R, Plewes DB, Narod SA. Long-term results of screening with magnetic resonance imaging in women with BRCA mutations. Br J Cancer 2012 Jun 26;107(1):24-30. doi: 10.1038/bjc.2012.204. Epub 2012 May 15.

Perren TJ, Swart AM, Pfisterer J, Ledermann JA, Pujade-Lauraine E, Kristensen G, Carey MS, Beale P, Cervantes A, Kurzeder C, du Bois A, Sehouli J, Kimmig R, Stähle A, Collinson F, Essapen S, Gourley C, Lortholary A, Selle F, Mirza MR, Leminen A, Plante M, Stark D, Qian W, Parmar MK, Oza AM; ICON7 Investigators. A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 2011 Dec 29;365(26):2484-96. Erratum in: N Engl J Med. 2012 Jan 19;366(3):284.

Petropoulos S, Gibb W, Matthews SG. Glucocorticoid regulation of placental breast cancer resistance protein (Bcrp1) in the mouse. Reprod Sci 2011 Jul;18(7):631-9. Epub 2011 May 20.

Pham AT, Kives S, Merovitz L, Nitsch R, Tessler K, Yudin MH. Screening for bacterial vaginosis at the time of intrauterine contraceptive device insertion: is there a role? J Obstet Gynaecol Can 2012 Feb;34(2):179-85.

Phillips DI, Matthews SG. Is perinatal neuroendocrine programming involved in the developmental origins of metabolic disorders? World J Diabetes 2011 Dec 15;2(12):211-6.

PUBLICATIONS 2011-2012 96

Ranney ML, Rennert-May E, Spitzer R, Chitai MA, Mamlin SE, Mabeya H. A novel ED-based sexual assault centre in western Kenya: description of patients and analysis of treatment patterns. Emerg Med J 2011 Nov;28(11):927-31. Epub 2010 Oct 14.

Ray JG, Schull MJ, Kingdom JC, Vermeulen MJ. Heart failure and dysrhythmias after maternal placental syndromes: HAD MPS Study. Heart 2012 May 16. [Epub ahead of print]

Ray JG, Sgro M, Mamdani MM, Glazier RH, Bocking A, Hilliard R, Urquia ML. Birth weight curves tailored to maternal world region. J Obstet Gynaecol Can 2012 Feb;34(2):159-71.

Rennie MY, Detmar J, Whiteley KJ, Jurisicova A, Adamson SL, Sled JG. Expansion of the fetoplacental vasculature in late gestation is strain dependent in mice. Am J Physiol Heart Circ Physiol 2012 Mar 15;302(6):H1261-73. Epub 2012 Jan 20.

Reproductive Endocrinology and Infertility Committee [Sierra S]; Family Physicians Advisory Committee; Maternal-Fetal Medicine Committee; Executive and Council of the Society of Obstetricians, Liu K, Case A. Advanced reproductive age and fertility. J Obstet Gynaecol Can 2011 Nov;33(11):1165- 75.

Retnakaran R, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Hamilton JK. Effect of maternal weight, adipokines, glucose intolerance and lipids on infant birth weight among women without gestational diabetes mellitus. CMAJ 2012 May 22. [Epub ahead of print]

Retnakaran R, Qi Y, Sermer M, Connelly PW, Hanley AJ, Zinman B. The postpartum cardiovascular risk factor profile of women with isolated hyperglycemia at 1-hour on the oral glucose tolerance test in pregnancy. Nutr Metab Cardiovasc Dis 2011 Sep;21(9):706-12. Epub 2011 Jun 23.

Retnakaran R, Qi Y, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B. Hepatic insulin resistance is an early determinant of declining β-cell function in the first year postpartum after glucose intolerance in pregnancy. Diabetes Care 2011 Nov;34(11):2431-4. Epub 2011 Sep 16.

Robertson JR, Drutz HP. My mentors in urogynecology. Int Urogynecol J 2011 Oct;22(10):1209-10. Epub 2011 Jul 28.

Rolfo A, Garcia J, Todros T, Post M, Caniggia I. The double life of MULE in preeclamptic and IUGR placentae. Cell Death Dis 2012 May 3;3:e305. doi: 10.1038/cddis.2012.44.

Roscioli T, Kamsteeg EJ, Buysse K, Maystadt I, van Reeuwijk J, van den Elzen C, van Beusekom E, Riemersma M, Pfundt R, Vissers LE, Schraders M, Altunoglu U, Buckley MF, Brunner HG, Grisart B, Zhou H, Veltman JA, Gilissen C, Mancini GM, Delrée P, Willemsen MA, Ramadža DP, Chitayat D, Bennett C, Sheridan E, Peeters EA, Tan-Sindhunata GM, de Die-Smulders CE, Devriendt K, Kayserili H, El-Hashash OA, Stemple DL, Lefeber DJ, Lin YY, van Bokhoven H. Mutations in ISPD cause Walker- Warburg syndrome and defective glycosylation of α-dystroglycan. Nat Genet 2012;44(5):581-5.

Rossant J. The impact of developmental biology on pluripotent stem cell research: successes and challenges. Dev Cell 2011 Jul 19;21(1):20-3.

Rugg-Gunn PJ, Cox BJ, Lanner F, Sharma P, Ignatchenko V, McDonald AC, Garner J, Gramolini AO, Rossant J, Kislinger T. Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Dev Cell 2012 Apr 17;22(4):887-901. Epub 2012 Mar 15.

PUBLICATIONS 2011-2012 97

Saunders NR, Hellmann J, Farine D. Cerebral palsy and assisted conception. Obstet Gynaecol Can 2011 Oct;33(10):1038-43. Review.

Schrey S, Kelly EN, Langer JC, Davies GA, Windrim R, Seaward PG, Ryan G. Fetal thoracoamniotic shunting for large macrocystic congenital cystic adenomatoid malformations of the lung. Ultrasound Obstet Gynecol 2012 May;39(5):515-20. doi: 10.1002/uog.11084.

Shaffer LG, Dabell MP, Rosenfeld JA, Neill NJ, Ballif BC, Coppinger J, Diwan NR, Chong K, Shohat M, Chitayat D. Referral patterns for microarray testing in prenatal diagnosis. Prenat Diagn 2012 Jun;32(6):611. doi: 10.1002/pd.3909. No abstract available.

Shrim A, Koren G, Yudin MH, Farine D. Management of varicella infection (chickenpox) in pregnancy. J Obstet Gynaecol Can 2012 Mar;34(3):287-92.

Shore EM, Yudin MH. Choice of antibiotic for group B streptococcus in women in labour based on antibiotic sensitivity testing. J Obstet Gynaecol Can 2012 Mar;34(3):230-5.

Shynlova O, Lee YH, Srikhajon K, Lye S. Physiologic Uterine Inflammation and Labor Onset: Integration of Endocrine and Mechanical Signals. Reprod Sci 2012 May 21. [Epub ahead of print]

Sodek KL, Murphy KJ, Brown TJ, Ringuette MJ. Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis. Cancer Metastasis Rev 2012 Jun;31(1-2):397-414. Sword W, Landy CK, Thabane L, Watt S, Krueger P, Farine D, Foster G. Is mode of delivery associated with postpartum depression at 6 weeks: a prospective cohort study. BJOG 2011 Jul;118(8):966-77. doi: 10.1111/j.1471-0528.2011.02950.x. Epub 2011 Apr 13.

McArdle WL, Mølgaard A, Newnham JP, Palmer LJ, Palotie A, Pouta A, Ring SM, Sovio U, Standl M, Uitterlinden AG, Wichmann HE, Vissing NH, DeCarli C, van Duijn CM, McCarthy MI, Koppelman GH, Estivill X, Hattersley AT, Melbye M, Bisgaard H, Pennell CE, Widen E, Hakonarson H, Smith GD, Heinrich J, Jarvelin MR, Jaddoe VW; Early Growth Genetics Consortium. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet 2012 Apr 15;44(5):532-8. doi: 10.1038/ng.2238.

McGee J, Kotsopoulos J, Lubinski J, Lynch HT, Rosen B, Tung N, Kim-Sing C, Karlan B, Foulkes WD, Ainsworth P, Ghadirian P, Senter L, Eisen A, Sun P, Narod SA. Anthropometric Measures and Risk of Ovarian Cancer Among BRCA1 and BRCA2 Mutation Carriers. Obesity (Silver Spring) 2012 Jun;20(6):1288-92. doi: 10.1038/oby.2011.394. Epub 2012 Jan 19.

Stevens KN, Kelemen LE, Wang X, Fridley BL, Vierkant RA, Fredericksen Z, Armasu SM, Tsai YY, Berchuck A, Narod SA, Phelan CM, Sutphen R, Birrer MJ, Schildkraut JM, Sellers TA, Goode EL; Ovarian Cancer Association Consortium, Couch FJ. Common variation in Nemo-like kinase is associated with risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev 2012 Mar;21(3):523-8. Epub 2012 Jan 17.

Tamplin OJ, Cox BJ, Rossant J. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Dev Biol 2011 Dec 15;360(2):415-25. Epub 2011 Oct 8.

Thériault BL, Pajovic S, Bernardini MQ, Shaw PA, Gallie BL. Kinesin family member 14: an independent prognostic marker and potential therapeutic target for ovarian cancer. Int J Cancer 2012 Apr 15;130(8):1844-54. doi: 10.1002/ijc.26189. Epub 2011 Aug 5.

PUBLICATIONS 2011-2012 98

Tsoref D, Oza AM. Recent advances in systemic therapy for advanced endometrial cancer. Curr Opin Oncol 2011 Sep;23(5):494-500. Review.

Tsui AK, Marsden PA, Mazer CD, Adamson SL, Henkelman RM, Ho JJ, Wilson DF, Heximer SP, Connelly KA, Bolz SS, Lidington D, El-Beheiry MH, Dattani ND, Chen KM, Hare GM. Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia. Proc Natl Acad Sci U S A 2011 Oct 18;108(42):17544-9. Epub 2011 Oct 5.

Van Eyk N, van Schalkwyk J; Infectious Diseases Committee [Yudin M]. Antibiotic prophylaxis in gynaecologic procedures. J Obstet Gynaecol Can 2012 Apr;34(4):382-91. van Mieghem T, Baud D, Devlieger R, Lewi L, Ryan G, De Catte L, Deprest J. Minimally invasive fetal therapy. Best Pract Res Clin Obstet Gynaecol 2012 Jun 6. [Epub ahead of print]

Vaughan S, Coward JI, Bast RC Jr, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, Friedlander M, Gabra H, Kaye SB, Lord CJ, Lengyel E, Levine DA, McNeish IA, Menon U, Mills GB, Nephew KP, Oza AM, Sood AK, Stronach EA, Walczak H, Bowtell DD, Balkwill FR. Rethinking ovarian cancer: recommendations for improving outcomes. Nat Rev Cancer 2011 Sep 23;11(10):719-25. doi: 10.1038/nrc3144.

Verma P, Clark CA, Spitzer KA, Laskin CA, Ray J, Koren G. Use of non-aspirin NSAIDs during pregnancy may increase the risk of spontaneous abortion. Evid Based Nurs 2012 Mar 12. [Epub ahead of print]

Vicus D, Beiner ME, Clarke B, Klachook S, Le LW, Laframboise S, Mackay H. Ovarian immature teratoma: treatment and outcome in a single institutional cohort. Gynecol Oncol 2011 Oct;123(1):50-3. Epub 2011 Jul 20. Walker MG, Fitzgerald B, Keating S, Ray JG, Windrim R, Kingdom JC. Sex-specific basis of severe placental dysfunction leading to extreme preterm delivery.Placenta 2012 Jul;33(7):568-71. Epub 2012 Apr 17.

Walker MG, Colman J, Silversides CK, Gandhi S, Kingdom J. Maternal atrial arrhythmia detected by uterine artery Doppler. J Obstet Gynaecol Can 2011 Aug;33(8):851-3.

Walker MG, Fitzgerald B, Keating S, Ray JG, Windrim R, Kingdom JC. Sex-specific basis of severe placental dysfunction leading to extreme preterm delivery. Placenta. 2012 Jul;33(7):568-71. Epub 2012 Apr 17.

Wan J, Yourshaw M, Mamsa H, Rudnik-Schöneborn S, Menezes MP, Hong JE, Leong DW, Senderek J, Salman MS, Chitayat D, Seeman P, von Moers A, Graul-Neumann L, Kornberg AJ, Castro-Gago M, Sobrido MJ, Sanefuji M, Shieh PB, Salamon N, Kim RC, Vinters HV, Chen Z, Zerres K, Ryan MM, Nelson SF, Jen JC. Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration. Nat Genet 2012 Apr 29;44(6):704-8. doi: 10.1038/ng.2254.

Weinstock C, Bigenwald R, Hochman T, Sun P, Narod SA, Warner E. Outcomes of surveillance for contralateral breast cancer in patients less than age 60 at the time of initial diagnosis. Curr Oncol 2012 Jun;19(3):e160-4.

PUBLICATIONS 2011-2012 99

Wertaschnigg D, Jaeggi M, Chitayat D, Shannon P, Ryan G, Thompson M, Yoo SJ, Jaeggi E. Prenatal Diagnosis and Outcome of Absent Pulmonary Valve Syndrome: Contemporary Single Center Experience and Review of the Literature. Ultrasound Obstet Gynecol 2012 May 17. doi: 10.1002/uog.11193. [Epub ahead of print]

Widdows K, O'Malley A, O'Neill B, Kingdom J, Gillan J, Ansari T. Altered placental development in pregnancies resulting in sudden infant death syndrome (SIDS). Early Hum Dev 2012 Jun 15. [Epub ahead of print]

Windrim CM, Kingdom J. Posterior suture avulsion following cervical cerclage. Ultrasound Obstet Gynecol 2012 Mar;39(3):359-60. doi: 10.1002/uog.10087. Epub 2012 Feb 9.

Wong S, Ordean A, Kahan M; Society of Obstetricians and Gynecologists of Canada [Farine D]. SOGC clinical practice guidelines: Substance use in pregnancy: no. 256, April 2011. Int J Gynaecol Obstet 2011 Aug;114(2):190-202.

Xie N, Liu L, Li Y, Yu C, Lam S, Shynlova O, Gleave M, Challis JR, Lye S, Dong X. Expression and Function of Myometrial PSF Suggest a Role in Progesterone Withdrawal and the Initiation of Labor. Mol Endocrinol 2012 Jun 5. [Epub ahead of print]

Yang J, Noyan-Ashraf MH, Meissner A, Voigtlaender-Bolz J, Kroetsch JT, Foltz W, Jaffray D, Kapoor A, Momen A, Heximer SP, Zhang H, van Eede M, Henkelman RM, Matthews SG, Lidington D, Husain M, Bolz SS. Proximal Cerebral Arteries Develop Myogenic Responsiveness in Heart Failure via TNFα- Dependent Activation of S1P Signaling. Circulation 2012 Jun 5. [Epub ahead of print]

Yee S, Fuller-Thomson E, Lau A, Greenblatt EM. Fertility Preservation Practices Among Ontario Oncologists. J Cancer Edu 2012;27(2):362-8. (Epub Jan 2012).

Yee S, Abrol K, McDonald M, Tonelli M, Liu KE. Addressing oncofertility needs: Views of female cancer patients in fertility preservation. J Psychosoc Onc 2012; 30(3):331-46.

Yudin MH. Optimizing knowledge of antiviral medications for prophylaxis and treatment of influenza during pregnancy. Expert Rev Respir Med. 2011 Aug;5(4):495-501. Review.

Zhang X, Leung C, Lu Z, Esfandiari N, Casper RF, Sun Y. Controlled aspiration and positioning of biological cells in a micropipette. IEEE Trans Biomed Eng 2012 Apr;59(4):1032-40. Epub 2012 Jan 3.

5.2 Appendix: Research Grants 2007-2008 to 2011-2012

2007-2008

RESEARCH GRANTS AND INVESTIGATIONS

Adamson SL (Principal Investigator), Cardiovascular phenotyping in embryonic and newborn mice. Canadian Institutes of Health Research – Equipment and Maintenance Program, $122,109 total, $81,984 per annum Equipment, $8,025 per annum Operating, 2005 – 2010.

Adamson SL (Principal Investigator); Bocking AD, Caniggia I, Casper RF, Challis JR, Jurisicova A, Kingdom JC, Langille BL, Lye SJ, Rossant J (Co-Investigators). CIHR Group in Development and Fetal Health. Canadian Institutes of Health Research Group Grant, $1,876,250 total, $375,250 per annum, October 2005 – September 2010.

Adamson SL (Principal Investigator), Foster RS (Co-Investigator). Cardiovascular phenotyping in embryonic and newborn mice. Canadian Institutes of Health Research, Operating Program, $719,350 total, $170,668 per annum + $36,678 Equipment, 2004 – 2008.

Adamson SL (Principal Investigator), Rossant J (Co-Principal Investigator); Osborne L, Bruneau BG (Co-Applicants). Generation and physiological analysis of genome-wide mutations in mice. Canadian Institutes of Health Research – Operating Program, $1,293,687 total, $250,909 per annum + $39,142 Equipment, 2004 – 2009.

Alarab M, Drutz HP (Principal Investigators), Lovatsis D, Shynlova O, Lye S. (Co- Investigators). Different patterns of gene expression in pelvic tissue of women with and without pelvic organ prolapse. Sponsor: Finance Committee of Department of Obstetrics and Gynaecology, Mount Sinai Hospital, $11,830, 2006 – 2007.

Alarab M, Drutz HP. (Principal Investigators), Pascali D, Maslow K. (Co-Investigators) Prospective, randomized, double-blind placebo-controlled trial of the safety and efficacy of continuous low-dose, estradiol releasing vaginal ring in patients with pelvic organ prolapse using pessaries. Sponsor: Paladin, $20,000, 2005 – 2007.

Angle P (Principal Investigator), Halpern SH, Kronberg J, Kiss A, Gawel M. Randomized controlled trial examining the effect of small versus large Tuohy-type epidural needles on the incidence and severity of postdural puncture headache. Canadian Anesthesiologists’ Society, $40, 000, July 1, 2007 – June 30, 2008.

Asztalos E, Murphy KE, Hannah ME, Ohlsson A, Kelly E, Saigal S, Matthews S, Amankwah A, Willan A, Gafni A. (Co- Investigators). MACS-5 Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study: Five year follow-up. Canadian Institutes of Health Research, # MCT 78775, $3,585,161, 2005 – 2012. Barrett J (Principal Investigator); Allen AC, Armson BA, Asztalos EV, Farrell SA, Gafni A, Hannah ME, Hutton EK, Joseph KS, Ohlsson A, Okun NB, Ross SJ, Willan AR (Co- Investigators). The Twin Birth Study: A multicentre randomized controlled trial comparing planned Caesarean section with planned vaginal birth for twins at 32-38 weeks’ gestation. Canadian Institutes of Health Research Grant Award (Randomized Controlled Trials), $8,608,045 total, $956,449 per annum, 2003 – 2011.

Belik J, (Principal Investigator) Letarte, M. (Co-Investigator). eNOS uncoupling and role of bone morphogenetic protein-9 in the regulation of pulmonary vascular tone during development and following pulmonary hypertension. Heart & Stroke Foundation. $173,812 total, $86,906 per annum, Operating Grant, 2007 – 2009.

Belsham DD (Principal Investigator). Canada Research Chair Award in Neurodocrinology, Tier 2, $500,000 total, $100,000 per annum, July 2004 – June 2009.

Belsham DD. (Principal Investigator). Circadian regulation of neuropeptides from the hypothalamus. Natural Sciences and Engineering Research Council, Operating Grant Renewal, $42,000 per annum, April 2007 – March 2012.

Belsham DD. (Principal Investigator). Immortalization and characterization of neurons from rat hypothalamus. Pfizer Global Research and Development, Research Contract, $156,020 per annum, December 2006 – December 2007.

Belsham DD. (Principal Investigator).Insulin signaling and synthesis in the brain. Canadian Diabetes Association, Operating Grant, $75,000 per annum, June 2006 – May 2008.

Belsham DD (Principal Investigator). Molecular mechanisms dictating control of neuroendocrine function by estrogen. Canadian Institutes of Health Research, Operating Grant, Renewal, $134,390 per annum, April 2004 -- March 2009.

Belsham DD. (Principal Investigator). Sensing of peripheral nutrient status by the hypothalamus. Canadian Institutes of Health Research, Operating Grant, $96,288 per annum, April 2005 – March 2008.

Belsham DD. (Principal Investigator). Sensing of peripheral nutrient status by the hypothalamus. Canadian Institutes of Health Research, Renewal, $158,154 per annum, April 2008 – March 2013.

Berger H (Co-Principal Investigator).Developmental outcomes of adolescents exposed in utero to corticosteroids - follow up of a randomized controlled study. SickKids Foundation, $151,800, May 2008.

Berger H (Principal Investigator), Windrim R, Young B, Dalfen A, Macleod A. Is postpartum anemia an independent risk factor for postpartum depression? Canadian Foundation for Women’s Health, $19,800, 2006 – 2008.

2 Berger H (Principal Investigator), Windrim R, Young B, Dalfen A, Macleod A. Is postpartum anemia an independent risk factor for postpartum depression? Canadian Foundation for Women’s Health, Renewal $19,800, 2008 – 2009.

Bierman AS (Principal Investigator), Abramson B, Angus J, Anderson G, Bayoumi A, Booth G, Dunn J, Dunn S, Dusek J, Ferris L, Glazier R, Hawker G, Jaakkimainen L, Khanlou N, Krzyzanowski M, Lin E, McDonald L, Manuel D, Moineddin R, Rabineck L, Rhodes A, Rochon P, Stewart DE, Stukel T (Co-Applicants). Ontario Women's Health Report Card: Improving health and promoting equity for the women of Ontario AKA Project for an Ontario Women's Health Evidence-Based Report Card (POWER). Ontario Ministry of Health and Long Term Care. $4,289,300, March 2006 – February 2009. Bocking AD, (Principal Investigator); Challis JR, Reid G (Co-Investigators). Role of lactobacilli in maternal and perinatal health. Canadian Institutes of Health Research, $96,070 per annum, 2007 – 2012.

Brown AD (Principal Investigator), Abramson B, Bierman A, Davis D, Laporte A, Levinton C, Maclean H, Mahomed N, Stewart DE, Wilson C (Co-Applicants). Measuring and understanding gender equity in access to care. Canadian Institutes of Health Research, $103,254, March 2006 – March 2009.

Brown TJ (Principal Investigator). Identification and functional analysis of nuclear receptor coactivator 4 isoforms expressed during mouse development. Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant, $36,500 per annum, 2005 – 2010.

Brown TJ (Principal Investigator), Jurisica I, Letarte MVT, Shaw PA, Murphy KJ, Rosen B (Co-Investigators). Functional characterization of androgen-altered genes with a putative role during early events in ovarian carcinogenesis. Canadian Institutes of Health Research, Operating Grant, $394, 000 total, $98,500 per annum, 2005 – 2009.

Bruneau B (Principal Investigator), Chitayat D. Genetic basis of cardiac development and malformation. Canadian Institutes of Health Research, $496,312, 2005 -- 2010.

Caccia N. Development of a Web-based course covering the basics of common problems in the delivery of sub-specialty care in Paediatric & Adolescent Gynaecology for Obstetrics & Gynaecology Post-Graduate Trainees at the University of Toronto. University of Toronto Information Technology Courseware Development Fund, $5000, 2008.

Campbell MK (Principal Investigator), Bocking AD (Co-Investigator). Maternal and infant health, health services needs and utilization following term and preterm birth; Outcomes in cohort assembled antenatally. Canadian Institutes of Health Research Operating Grant, $100,275 per annum, 2005 – 2009.

Caniggia I (Co-Applicant). Developing interventions to improve fertility rates and mother and neonatal survival. Canadian Foundation for Innovation/ Ontario Research Fund (CFI/ ORF), Provincial funding: $390,545 + equal match from CFI, 2008.

3 Caniggia I (Principal Investigator). Diagnostic markers for preeclampsia. BioDiscovery Toronto, $50,000, 2007.

Caniggia I (Co- Investigator). Identification of candidate pathways in intrauterine growth restriction: Important first step towards disease etiology. Physicians’ Services Incorporated Foundation Grant: $ 20,000, 2008.

Caniggia I (Principal Investigator). The role of oxygen in regulating placental development. Canadian Institutes of Health Research Operating Grant, $787,490 total, $156,000 per annum; 2008 – 2013.

Caniggia I. Towards understanding the pathogenesis of preeclampsia. Canadian Institutes of Health Research Ontario Women's Health Council/The Institute of Gender and Health (IGH) Mid-Career Award, $80,000 per annum, 2005 -- 2010.

Caniggia I (Principal Investigator), Jurisicova A (Co-Investigator). Role of Bcl-2 family members in regulating placental cell fate. Canadian Institutes of Health Research Operating Grant, $ 757,050 total, $150,000 per annum, 2008 – 2013.

Casper RF (Principal Applicant). Optical filters for prevention of circadian rhythm disruption in shift workers. Ontario Centres of Excellence MR grant, $127,500, 2008.

Casper RF (Principal Investigator). Brown TJ, Shapiro C. Prevention of circadian rhythm disruption by nocturnal lighting. CIHR, Operating Grant, $211,360 per annum, 2008 -- 2011.

Casper RF, Jurisicova A (Principal Applicants), Perez GI. (Co-Applicant). Enhancing early embryo development in assisted reproduction. Canadian Institutes of Health Research Operating Grant – MOP 14058, $121,240 per annum, April 2005 – March 2010.

Casper RF, Rogers I. (Principal Applicants). Umbilical cord blood stem cells for tissue therapeutics. Insception Biosciences Inc., $315,000 per annum, 2003 – present.

Challis JRG (Principal Investigator), Bloomfield F, Gluckman P, Matthews S, Newnham J. Control of parturition. Canadian Institutes of Health Research (CIHR) Group in Fetal and Neonatal Health and Development, Operating Grant (Renewal), $1,138,000 total, $227,600 per annum, $113,800 first and last year, 2004 – 2010.

Challis JRG, Lye SJ (Co-Principal Investigators). Paracrine controls of human labour. Canadian Institutes of Health Research, $792,120; $158,424 per annum; Operating grant, October 2005 – September 2010.

Challis JRG (Principal Investigator), Lye SJ, MacCalman CD, Rurak DW, Gibb W. Regulation of prostaglandin synthesis, metabolism and action in pregnancy and parturition. Canadian Institutes of Health Research, Operating Grant, $792,450; $158,490 per annum, October 2004 – September 2009.

4 Challis JRG (Principal Investigator), Matthews SG. Control of parturition. Canadian Institutes of Health Research, Operating Grant, $1,050,000 total, $210,000 per annum, 2004 – 2009.

Classens C (Principal Investigator), Co-Principal Investigators: Ferguson SE, Urowitz S, Wiljer D. Development of an internet-based support group for sexual problems due to gynecologic cancer. National Cancer Institute of Canada (NCIC), $35,000, May 1, 2008 – April 30, 2010.

Covens A (Principal Investigator). A randomized, double-blind, placebo controlled, phase 2 trial of Paclitaxel in combination with AMG 386 in subjects with advanced recurrent epithelial ovarian or primary peritoneal cancer. Amgen, $100,000, April 2008 – September 2008.

Covens A (Principal Investigator). Phase III double-blinded placebo-controlled study of Kepivance (KGF) to reduce the severity and duration of vulvar mucositis and moist desquamation in patients undergoing vulvar chemo-radiation for carcinoma of the vulva. Gynecologic Oncology Group/NCI (CTEP), $US 500,000, 2006 – 2009.

Dennis CL (Principal Investigator), Stewart DE (Co-Applicant). An RCT to Evaluate the Effectiveness of Peer Support for PPD. Canadian Institutes of Health Research, $1,005,526, January 2004 – January 2008. Derzko CM (Principal Investigator). A Phase III, randomized, double-blind, placebo-controlled, multi-center study of the safety and efficacy of LibiGel for the treatment of Hypoactive Sexual Desire Disorder in surgically menopausal women. BioSante Protocol No TESTW008, Total Operating Budget: $87,074, Total cost per completed subject: $6,715, 2008 – ongoing.

Derzko CM (Principal Investigator). Efficacy and safety of two low-dose regimens of conjugated estrogen cream administered vaginally in postmenopausal women with atrophic vaginitis. Wyeth Protocol 0713S5-413-NA, Total operating budget $58,475, $4,657.50 per completed subject, 2005 – 2007.

Derzko CM (Principal Investigator). The effect of dose titration and dose tapering on the tolerability of DVS SR in women with vasomotor symptoms associated with menopause. Wyeth Protocol 3151A2-405-NA, Total operating budget: $91,890, Total cost per completed subject: $5,102.50, 2006 – 2008.

Derzko CM (Principal Investigator), Josse R (Co-Applicant). A double-blind, randomized, placebo-controlled study assessing the safety and efficacy of DVS SR for the treatment of vasomotor symptoms associated with menopause. Wyeth, $162,950 total, 2008 – ongoing.

Dodd J, Bocking A, Windrim R, Whittle W. Progesterone after previous preterm birth for prevention of neonatal respiratory distress syndrome (PROGRESS). National Health and Medical Research Council of Australia, $1,100,000, 2006 – 2008.

Drutz HP (Principal Investigator). A 12 month double-blind, randomized placebo-controlled multi-centered trial to investigate the efficacy and safety of Vagifem low dose (10ug) 17 Beta estradiol vaginal table) for the treatment of postmenopausal atrophic vaginitis symptoms. Protocol Nu: Vag – 2195. Novo Nordisk, Grant, $13,928, 2007 – 2008.

Drutz HP (Principal Investigator). A randomized double-blind study to assess the safety and efficacy of Solifenacin (Vesicare®) in comparison to Oxybutynin for overactive bladder patients. Protocol Nu: VES-001 VECTOR. Astellas Pharma Canada. Grant: $15,130, 2007 – 2008.

Drutz HP (Principal Investigator). An open, non-comparative, post marketing, multi-center study to evaluate efficacy and Safety of Solesta™ for the treatment of fecal incontinence. Protocol: Q-Med AB: Protocol 33DA0605. Sponsor: Q-Med AB Grant: Initial $20,000, 2007 – 2009.

Drutz HP (Principal Investigator). Randomized, evaluator-blinded, multi-center study comparing the efficacy and safety of Zuidex™ with Contigen® in female patients with stress urinary incontinence. Protocol: No. 33DS0201 Zuidex. Q-Med, AB Grant, $211, 419, 2004 – 2007.

Dupre J (Principal Investigator), Dosch H-M, Lawson ML, Orbine E, Fraser WD, Sermer M (Principal Investigator, Toronto Site). Trial to reduce Insulin Dependent Diabetes Mellitus (IDDM) in the genetically at risk (TRIGR). National Institutes of Health, Canadian Institutes of Health Research, $426,000 per annum, 2002 – 2012.

Ferguson SE (Principal Investigator), Co-Principal Investigators: Urowitz S, Classens C. Development and validation of the modified sexual adjustment and body image scale in women with a diagnosis of gynecologic cancer (SABIS-G). Research Award through Department of Obstetrics and Gynecology, University of Toronto, $5000, 2008.

Fleshner N (Principal Investigator), Brown TJ, Done S, Jurisica I, Lockwood G, Sweet J. Identification and characterization of alterations at the stroma-epithelial interface in prostate cancer. Ontario Cancer Research Network (OCRN), Operating Grant, $544,312, 2007 – 2010.

Friedman JM (Principal Investigator), Chitayat D. Canadian Molecular Cytogenetics Platform. Canadian Foundation for Innovation, $4,512,925, 2005 – 2010.

Friedman JM (Principal Investigator), Chitayat D. Identifying human mutations that cause mental retardation. Canadian Institutes of Health Research, $2,498,538, 2005 – 2010.

Gagnon AJ (Principal Investigator), Dennis C, Oxman-Martinez J, Stewart DE, Dougherty G, Saucier J, Wahoush E, George M, Stanger E (Co-Principal Investigators). The childbearing health and related service needs of newcomers (CHARSNN). Canadian Institutes of Health Research, $2,539,005, March 2004 – March 2008.

Gagnon AJ (Principal Investigator), Heaman MI, Small RE, Stewart DE, Zencovich ME (Co- Applicants). International comparisons of the perinatal health and care of migrant women. Canadian Institutes of Health Research, $100,000, March 2006 – March 2008.

6 Grace SL, Stewart DE (Co-Principal Investigators), Scholey P, Holder G, Kaur R, Rukholm E, Alter D, Rush J, Anand S, Williamson K, Harvey P, Oh P, Bunker S (Co-Applicants). Cardiovascular secondary prevention for vulnerable populations: An interdisciplinary approach to improving access to services and outcomes. Reducing health disparities and promoting equity for vulnerable populations. Canadian Institutes of Health Research and Heart and Stroke Foundation of Canada, Interdisciplinary capacity enhancement grants CIHR IGH, ICRH and HSFC, $704,792, April 2006 – March 2011.

Grace SL (Principal Investigator), Co-applicants: Suskin N, Arthur HM, Prior P, Reid R, Stewart DE. Comparing paper versus electronic transmission of cardiac rehabilitation summaries to primary care physicians: A multi-site multi-method study of information flow and content (the CR2DoC study). Canadian Institutes of Health Research, MOP-74431, $324,697, April 2008 –March 2011.

Grace SL, Stewart DE, Suskin N, Alter, DA, Higginson L (Co-Principal Investigators). Contribution of patient and physician factors to cardiac rehabilitation referral and participation: A prospective, multi-level study. Canadian Institutes of Health Research, $220,840, April 2005 – May 2008.

Grynpas MG (Principal Investigator); Adamson SL, Bazett-Jones DP, Brumell JH, Grinstein S, Keeley FW, McKerlie C, Quaggin SE, Tenenbaum HC, Zhen M (Co-Investigators). Maintenance of the Advanced Bioimaging Centre. Canadian Institutes of Health Research, Maintenance Grant, $563,180 total ($112,636 per annum), 2006 – 2011.

Gucciardi E (Principal Investigator), DeMelo M, Medeiros L, Tarasuk V, Stewart DE (Co- Applicants). Food insecurity in Canadians with diabetes mellitus. Canadian Diabetes Association, $20,000, July 2007 – July 2008.

Han VKM (Principal Investigator), Adamson SL, Avison WR, Cambell MK, Gagnon R, Hill DJ, Lee T-Y, Mann M, Richardson BS, Speechley KN, Thompson RT, Yang K (Co- Investigators). Fetal growth restriction: Mechanisms and outcomes. Canadian Institutes of Health Research, Healthy Pregnancy for Great Life Beginnings Program, $1,675,006 total ($322, 271 per annum + $63,650 Equipment), 2005 – 2010.

Hodgson D (Principal Investigator), Greenblatt EM, Catton P, Sridhar S, Azad A (Co-Investigators), McArdle O. Fertility in young breast cancer survivors – a novel assessment of ovarian reserve. Canadian Breast Cancer Foundation, $330,391, March 2008 – March 2011.

Hutton E (Principal Investigator), Willan A, Hannah ME, Gafni A, Ohlsson A, Barrett J, Ross S, Windrim R, Delisle MF, Carson G, Dunn M, Pollard J, Natale R (Co-investigators). Early External Cephalic Version-2 Trial. Canadian Institutes of Health Research, $2,853,717, 2003 – 2008.

Hutton E (Principal Investigator), Willan A, Hannah M, Gafni A, Ohlsson A, Barrett J, Ross S, Windrim R, Delisle M-F, Carson GD, Dunn M, Pollard JK, Natale R, Sylvestre G. External cephalic version-2 trials. Canadian Institutes of Health Research, $ 169,822, 2008 – 2009.

7 Johnson N, Windrim R, Whittle WL. Role of amniocentesis for patient selection prior to rescue cerclage. Mount Sinai Hospital, Department of Obstetrics and Gynaecology Research Fund, $4,610, 2007 – 2008.

Josse R (Principal Investigator), Derzko CM, Jamal S, Kraw M, Rubin L (Co-Investigators). A randomized, double-blind study to compare the efficacy of treatment with denosumab versus alendronate sodium in postmenopausal women with low bone mineral density. Amgen Protocol #20050141, 8,028 per patient, 2006 – 2008.

Josse R (Principal Investigator), Derzko CM, Jamal S, Kraw M, Rubin L (Co-Investigators). A multi-center, randomized, open-label study to assess the immunogenicity and safety of denosumab in pre-filled syringe compared to vial in subjects with low bone mineral density. Amgen Protocol #20060237, Total operating budget: $2,528 per patient, 2007 – 2009.

Josse R (Principal Investigator), Derzko CM, Rubin L (Co-Investigators). The efficacy and safety of 2g strontium ranelate in the treatment of male osteoporosis: A prospective multicentre, international, double-blind, placebo-controlled study with a treatment duration of 2 years and the main study analysis after 1 year. Servier Protocol CL3-12911-032 Total operating budget: $6,995 per patient, 2007 – 2011.

Josse R (Principal Investigator), Derzko C, Murray TM, Rubin L (Co-Investigators). Fracture incidence reduction and safety of TSE-424 (bazedoxifene acetate) compared to placebo and raloxifene in osteoporotic postmenopausal women. Wyeth Protocol 3068A1-301-CA. $17,000 per patient, 2002 – ongoing.

Josse R (Principal Investigator), Derzko CM, Rubin L (Co-Investigators). 52 week randomized double-blind, multicenter,mechanistic study with a 24 week open label follow-up to evaluate the effect of AVANDIA on bone in postmenopausal women with type 2 diabetes mellitus. GlaxoSmithKline Protocol ZM2007/00146/00, 2008 – 2010.

Jurisicova A. Importance of harakiri in regulation of oocyte and embryo survival. Canadian Institutes of Health Research, New Investigator Salary Support $50,000 per annum, 2003 – 2008.

Jurisicova A. (Principal Investigator), Adamson SL, Hakem R (Collaborators). Investigation of placental insufficiencies caused by Caspase 8 deficiency. Sick Kids Foundation/Canadian Institutes of Health Research, New Investigator Grant, $65,000 per annum, 2005 – 2008.

Jurisicova A (Principal Applicant), Greenblatt E, Jurisica I (Co-Applicants). Maternal lethal effect and human infertility. Canadian Institutes of Health Research, Operating grant, MOP- 8432, $132,750 per annum, 2007 – 2010.

Kim PCW, Ryan G, Chitayat D, Windrim R. Fetal Alert Network: Community-based Maternal Fetal Health Care Network, Ministry of Health and Long Term Care, $3,877,500, 2005 – 2008.

8 Kim PW, Ryan G (Project Co-leaders). The Fetal Alert Network. Ministry of Health and Long Term Care, One-time operating funds, $1,000,000, 2007-2008.

Kim PW, Ryan G (Project Co-leaders). Center for Computer-Assisted Intervention and Innovation (CCAII). Ontario Research Fund (partnership: SickKids (1/3), industry partners (1/3), provincial government (1/3)), $3,300,000, 2008 – 2012.

Kives S. Randomized controlled trial of continuous oral contraceptives vs. cyclical oral contraceptives in adolescents. Physicians’ Services Incorporated Foundation, $75,000.

Kingdom JCP (Principal Investigator). Villous trophoblast turnover. Canadian Institutes of Health Research Award, $532,888, 2006-2010.

Kingdom J, Czikk M (Co-Principal Investigators). Identification of candidate pathways in intrauterine growth restriction: Important first step towards disease etiology. Physicians Services Incorporated Foundation, Resident Research Grant, $19,560, 2008 – 2009.

Kingdom J, Jain V (Co-Principal Investigators) Induction and characterization of IUGR by sub- lethal injections of Gcm-1 siRNA into the embryonic exocoelomic cavity in mice. Physicians’ Services Incorporated Foundation, Resident Research Grant, $19,500, January – December 2007.

Kingdom J (Principal Investigator), McLeod K, Windrim R (Co-investigators). Randomised trial of heparin in women with severe placental dysfunction. Physicians’ Services Incorporated Foundation, $80,000, 2007.

Kingdom J, Sled JG (Co-Investigators) Three dimensional quantification of the placental vascular tree: Relationship with normal and abnormal fetal growth and hemodynamics. Heart and Stroke Foundation of Canada, $132,171, 2006 – 2008; Renewal $153,042, 2008 – 2010.

Kingdom J, Roggensack A (Co-Principal Investigators). Gene expression in fetal microvascular endothelial cells in fetal growth restriction study. Physicians’ Services Incorporated Foundation, Resident Research Grant, $19,500, January – December 2007.

Lambe EK. Cellular and molecular mechanisms underlying development and plasticity of prefrontal attention circuitry. Canadian Institutes of Health Research, $718,025 total; $143,605 per annum, 2008 – 2013.

Lambe EK. Signal transduction and adult cortical network activity. NAtional Science And Engineering Research Council (NSERC) Discovery Grant (Operating), $178,125 total ; $35,625 per annum, 2007 – 2012.

Langille BL. Arterial responses to hemodynamic stresses. Heart and Stroke Foundation of Ontario (T 4083), $112,007 per annum, 2002-07; $91,308 per annum, 2007-10; 2002 – 2010.

9 Langille BL. Cadherins and regulation of smooth muscle cell function. Heart and Stroke Foundation of Ontario (NA 5332), $74,196.00 per annum 2004-07; $125,957 per annum 2007- 12; 2004 – 2012.

Langille BL, Gotlieb A. Influence of hemodynamics on arterial endothelium. CIHR (MT 15044), $105,452, 2007 – 2012.

Lee SK (Principal Investigator), Aziz K, Baker GR, Barrington K, Clarke MCW, Cronin CM, Dunn MS, James A, Langley J, Lee DS, Lefebvre F, Merchant P, Ohlsson A, Orrbine E, Peliowski A, Sankaran K, Seshia M, Shaw NT, Synnes AR, Tan-Dy CR, Walker CR, Whyte RK. National health partnership for reducing infections in NICU. Canadian Institutes of Health Research, $ 99,999.00, 2005 – 2008.

Lee KS (Principal Investigator), Baker GR, Langley JM, MacNab YC, Moehr JR, Ohlsson A, Stevens B, Magee L, Sauve R, Keller P, Michalos A, Klassen A et al. Quality of care ICE (QC- ICE) team in neonatal-perinatal care. $935,000, 2003 – 2007.

Lee SK (Principal Investigator), Ohlsson A, Shaw N, Liston R, Armson A, Aziz K, Baker R, Saigal S, Skarsgard E, Hayward R, Dendukuri N, O'Campo P, Magee L, Sauve R, Stevens B, Joseph KS, Barrington K, El-Hajj M. CIHR Team in Maternal-Infant Care (MICare) grant, Canadian Institutes of Health Research, $ 4,902,135 total, $980,427 per annum + Equipment grant of $22,000, 2008 – 2012.

Letarte M (Principal Investigator). Endoglin, ALK-1 and BMPRII networks: Role in vascular disorders. Canadian Institutes of Health Research. $722,615 total, $144,523 per annum, Operating Grant, 2005 – 2010.

Letarte M (Principal Investigator). Proteins differentially expressed in ovarian epithelium of BRCA1 carriers as potential biomarkers for ovarian cancer. Ovarian Cancer Canada, $30,000, Operating Grant, 2008 – 2009.

Letarte M (Principal Investigator). The role of endoglin in the normal vasculature and in the pathology of Hereditary Hemorrhagic Telangiectasia. Heart & Stroke Foundation, $370,767 total, $92,671 per annum, Operating Grant, 2005 – 2009.

Levitan RD (Principal Investigator), Matthews SG. Sociobiological and genetic predictors of the stress response in chronic major depression. Operating Grant, $200,000 total, $100,000 per annum, 2007 – 2009.

Leyland N (Principal Investigator). Co-Investigators: Fortin C, Martyn P. A single arm multicentred study of the efficacy of hysteroscopic tubal occlusion by radiofrequency ablation. Sierra Surgical Technologies, 2008.

Leyland N (Principal Investigator), Singh S, Boroditsky R (Co-Investigators). Feasibility Study – Evaluation of the radiofrequency ablation of uterine myomas wih intrauterine ultrasound guidance. GYNESONICS, $500,000, 2008 – 2009.

10 Lilge L (Principal Investigator), Derzko C (Co-Applicant). Short term evaluations of breast tissue change in post-menopausal women using otpical breast spectroscopy (OBS). Princess Margaret Hospital Foundation – Weekend Walkers Breast Cancer Innovation Fund, $84, 655 total, April 2008 – March 2010.

Lye SJ (Principal Investigator), Adamson L, Andrulis I, Bernstein A, Briollais L, Bull S, Casper R, Cordes S, Culotti J, Dennis J, Durocher D, Esplen, MJ, Fantus I, Gallinger S, Grynpas M, Hogue C, McLaughlin J, Pawson A, Rossant J, Zinman, B. The Samuel Lunenfeld Research Institute Training Program: Applying genomics to human health. Canadian Institutes of Health Research (Strategic Training Initiative), $1,800,000 total, $300,000 per annum, April 2002 – March 2008.

Lye SJ (Principal Investigator); Adamson SL, Challis JRG, Danska S, Matthews S, Osborne L, Pennell C, Rossant J (Co-Investigators). A murine model to investigate the mechanisms underlying DOHaD. Canadian Institutes of Health Research, Operating Grant (MOP 81238), $373,674 total, $124,558 per annum, October 2006 – September 2009.

Lye SJ (Principal Investigator), Beilin L, Briollais L, Challis J, Doherty D, Matthews S, Newnham J, Ozcelik H, Palmer L, Pennell C, Siminovitch K, Stanley F, van Eekelen J, Zubrick S. Gene environment interactions underlying the developmental origins of health and disease. Canadian Institutes of Health Research, $408,828 total, $136,276 per annum, April 2007 – March 2010.

Lye SJ (Principal Investigator), Bocking AD, Pennell C (Co-Investigators). The diagnosis of true pre-term labour. March of Dimes Birth Defects Foundation, US$351, 818, US$117,272 per annum, March 2005 – February 2008.

Lye SJ (Principal Investigator), Dunk C, Keating S, Maxwel Cl. Extra villous trophoblast mediated utero-placental vascular remodelling. Canadian Institutes of Health Research, $642,810 total, $128,562 per annum, April 2007 – March 2012.

Lye SJ (Principal Investigator), Langille L. Myometrial programming: A new concept underlying the control of myometrial contractility during pregnancy. Canadian Institutes of Health Research $727,080 total, $145,416 per annum, Operating grant, October 2005-September 2010.

Magee L, Liston R (Principal Investigators); Dadelszen P, Lee SK, Allen V, Ansermino JM, Barrett J, Piedboeuf B, Smith GN, Walker MC (Co-Principal Investigators), Whittle W (Site Coordinator). Birth under 29 weeks: Improving outcomes for mothers and babies. Canadian Institutes of Health Research, $330,858, 2005 – 2009.

Matthews SG, Meaney M (Co-Directors). Maternal adversity, vulnerability & neurodevelopment. Canadian Institutes of Health Research, Program Grant, $3,750,000 total, $750,000 per annum, 2003 – 2009.

11 Matthews SG (Principal Investigator). Maternal stress in pregnancy programs endocrine function and behaviour in adult offspring. Operating Grant, Natural Sciences and Engineering Research Council of Canada (NSERC), $237,500 total, $47,500 per annum, 2006 – 2011.

Matthews SG (Principal Investigator). Multidrug resistance in pregnancy. Canadian Institutes of Health Research, Operating Grant, $637,980 total, $127,596 per annum, 2005 – 2010.

Matthews SG (Principal Investigator). Multidrug resistance in the developing brain barrier: Fetal brain protection. Canadian Institutes of Health Research, Operating Grant, $449,548 total, $112,387 per annum, 2007 – 2011.

McCulloch C (Principal Investigator) , Brown TJ, Ringuette M. Bone sialoproteins in skeletal metastasis. CIHR, Operating Grant, $430,822, 2008 – 2011.

McKerlie C (Principal Investigator); Adamson SL, Aubin JE, Hu J, Hui C-C, Nagy A, Post M, Rossant J, Stanford WL, Vidal SM (Co-Investigators). Canadian mouse mutant repository: A core resource for mouse models of human disease. Canadian Institutes of Health Research, Research Resource Grant Program, $519, 036 total, $100,000 per annum + $18,991 for equipment, 2006 – 2011.

Meaney M (Principal Investigator). Matthews SG. Genes, Environment & Health Training Grant. Canadian Institutes of Health Research, Training Grant. $1,440,000 total, $240,000 per annum, 2003 – 2009.

Meffe F (Principal Investigator), Campbell D, Houston P, Nevins A, Lynch B (Co-investigators).The development, implementation and evaluation of an interprofessional education curriculum in maternity care for undergraduate students in nursing, midwifery and medicine. Interprofessional Education in Maternity Care Pilot Project. Ministry of Health and Long Term Care, Interprofessional Care Fund, $175,000, December 2007.

Meyer JH (Principal Investigator), Co-Applicants: Houle S, Stewart DE, Wilson AA. Neurochemical aspects of depression in women: Monoamine Oxidase A in the postpartum period. Canadian Institutes of Health Research. $309,000, April 2007 – March 2010.

Miller D, Covens A. (Principal Investigators). A Phase II trial of Pemetrexed (Alimta) as salvage therapy for failed low risk gestational trophoblastic tumor. Gynecologic Oncology Group/National Cancer Institute (NCI)(CTEP), $US 250,000, Operating grant, January 2006 – January 2008.

Morgan PJ, Tregunno D, Pittini R, Regehr G, Milne K, Zwarenstein M, Tarshis J. Determination of the psychometric properties of a behavioural marking system for obstetrical team training using high-fidelity simulation. Canadian Patient Safety Institute (CPSI), $119,340, March 2007.

Murphy KE (Principal Investigator), Hannah ME, Ohlsson A, Kelly E, Saigal S, Matthews S, Amankwah A, Willan A, Gafni A. MACS Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study. Canadian Institutes of Health Research $7,743,353, 2000 – 2010.

12 Murphy KJ (Principal Investigator), Bloom JA (Co-Investigator). Evaluation of the role of human papillomavirus and P-16 testing in cervical cancer screening. Giovanni and Concetta Guglietti Family Cancer Fund, Cervix, PMH Foundation, Cervical Cytology Grant, $200,000, 2006 – 2010.

Nagy A, Piret J, Bhatia M, Eaves C (Project Leaders), Humphries K, Karsan A, van der Kooy D, Lansdorp P, Lye S, Marra M, Rancourt D, Rossant J, Zandstra P. Derivation and primary characterization of human ES cells using defined and xeno-free conditions. Networks of Centres of Excellence (NCE) $289,803 total, $96,601 per annum, Operating grant, September 2005 – August 2008.

Nam, RK (Principal Investigator), Bell D, Chin J, Narod S, Lkotz L, Izawa J, So A, Aprikian A, Trachtenberg J, Jewett M, Toi A. Cross-Canada assessment of a new nomogram prediction tool for prostate cancer screening. National Cancer Institute of Canada (NCIC). $462, 084 total ($160,796: 2006 – 2007; $150,644: 2007 – 2008; $150,644: 2008 – 2009:), 2006 – 2009.

Nam RK (Principal Investigator), Narod SA, Trachtenberg J, Klotz L, Fleshner N, Jewett M, Sugar L, Toi A, Diamandis E. Prospective evaluation of prostate biopsies for prostate cancer detection. National Cancer Institute of Canada, $410,070, 2004 – 2007.

Nevo O (Principal Investigator); Bocking AD, Caniggia I (Co-Investigators). Expressions of pro (VEGF, PIGF) and anti (sFit-1) angiogenic factors in placentae of IUGR pregnancies. Physicians` Services Incorporated Foundation, $19,500, October 2006 – October 2007.

Olson D (Principal Investigator), Bocking AD. Preterm birth and healthy outcomes. Alberta Heritage Foundation for Medical Research (AHFMR), $1,000,000 per annum, 2008 – 2012.

Oza A, Hirte H, Biagi J, Hoskins P, Chu Q, Fleming G, Covens A, Morgan R, Lele S, Kwon J, McNamara M, Scudder S, Lenz H, Belani C. A Phase II study of VEGF-Trap in recurrent or metastatic gynecologic soft-tissue sarcomas. National Cancer Institute Cancer Evaluation Therapy Program (NCI (CTEP)), $US 250,000, July 2007 – July 2008.

Oza A, Hirte H, Covens A, Welch S, Kaizer L, Swenerton K, Provencher D, Biagi J, Sturgeon J (Principal Investigators). A Phase 2 study of Oral MKC-1 administered twice daily for 14 consecutive days every 4 weeks in patients with recurrent or resistant epithelial ovarian cancer or advanced endometrial cancer. National Cancer Institute Cancer Evaluation Therapy Program (NCI (CTEP)) US$250,000, 2007 – 2009.

Oza A, Townsley C, Hirte H, Carey M, Fung Kee Fung M, Hoskins P, Covens A (Principal Investigators). A phase 2 Study of sunitinib malate in recurrent or metastatic endometrial carcinoma. National Cancer Institute Cancer Evaluation Therapy Program (NCI (CTEP))NCI (CTEP), US$250,000, 2007 – 2008.

Oza A, Townsley C, Hirte H, Carey M, Fung Kee Fung M, Hoskins P, Covens A (Principal Investigators). A Phase 2 study of PXD101 in platinum-resistant epithelial ovarian tumors and micropapillary/borderline (LMP) ovarian tumors. National Cancer Institute Cancer Evaluation Therapy Program (NCI (CTEP)), $US 250,000, July 2007 – July 2008.

13 Pedersen D, Lopez V, Sharma B, Piazza M, Chamindra Weerackody LP, Kirmayer LJ, Rousseau C, Young A, Guzder J, Stewart DE (Co-Investigators); Anckerman S, Flores MA, deVillagran M, Garcia HA, Chavez C, Jordans M, Kohrt B, Thapa S, Tol W, Castillo H, Cueva G, Mendoza M, Matos L, Calderon D, Rivera M, Fernando S, Amarasuriya H, Fernando S, Zarate CAJ (Co- Applicants). Political violence, natural disasters and mental health outcomes: Developing innovative health policies and interventions. International Development Research Centre. $1,599,542, January 2007 – January 2011.

Percy ME (National Coordinator, Canada; Principal Investigator, Surrey Place Centre Site); Dalton AJ (Project Principal Investigator); Aisen PS, Sano MC (Study Directors). Multicenter vitamin E trial in aging persons with Down syndrome. National Institute on Aging, National Institute of Child Health and Human Development, and National Center of Complementary and Alternative Medicine (RO1-AGO16381), Clinical trial, $9,000,000 (total), $1,129,849 (per annum, overall, 2007), $12,000 per annum, Surrey Place Centre site, 2000 – 2010.

Perumalla C (Primary Applicant), Belsham DD (Co-Applicant). Laboratory enrichment to enhance the educational experience of life sciences students. Academic Initiative Fund, $700,000, May 2007 – May 2009.

Ray JG. New Investigator Award. Canadian Institutes of Health Research. $250,000, 2005- 2010.

Ray JG. InterPreg Study. Canadian Institutes of Health Research. Operating Grant, $47,000 per annum, 2005 – 2010.

Ray JG, Wong DT, Goodman SG, Langer A, Leiter L. Atorvastatin Toronto Retinal Vein Occlusion (ATORVO) Study. Pfizer Canada, $540,668, 2005 – 2008.

Rogers I (Principal Investigator). Treatment of type 1 Diabetes with stem cells derived from human umbilical cord blood cells. BioDiscovery Toronto, $50,000, June 2007– May 2008.

Rogers I, Casper RF (Co-Principal Investigators). Multi-potential UCB cells. Insception Biosciences Inc., Grant, $1,700,000, January 2004 – June 2008.

Romans SE (Principal Investigator), Benazon LR, Einstein G, Kreindler D, Laredo, SE, Morgan K, Stewart DE, Toner BB (Co-Applicants). Mood changes and daily life. Canadian Institutes of Health Research, $395,000, February 2005 – February 2008.

Rossant J (Principal Investigator); Adamson SL, Aubin JE, Cordes SP, Osborne LR, Quaggin SE, Roder JC, Stanford WL, Vallis KA, Van Der Kooy DJ, Vidal SM. Centre for Modeling Human Disease. Canadian Institutes of Health Research Group Program, $2,532,330 total, $506, 466 per annum + $15,000 Equipment, 2004 – 2009.

Schmidt B (Principal Investigator), Roberts R, Barrington K, Ohlsson A, Solimano A, Davis P, Doyle L, Tin W. CAP follow-up at 5 years. Canadian Institutes of Health Research, $1,744,740, 2004 – 2009.

Sermer M (Co-Principal Investigator). Hemodynamics and hormonal changes in pregnant women with heart disease: Understanding the effects of pregnancy on the diseased heart. Heart and Stroke Foundation of Canada, $74,000 per annum, 2006 – 2008.

Sermer M (Co-Investigator). Longitudinal association of adipocytokines and markers of subclinical inflammation with changes in insulin resistance and beta-cell function in women with a history of gestational diabetes mellitus. Canadian Institutes of Health Research, $148,969 per annum, 2007 – 2012.

Sermer M (Co-Principal Investigator). Neurodevelopmental outcome in offspring of women with heart disease. Heart and Stroke Foundation of Canada, $123,080 per annum, 2006 – 2009.

Sermer M (Collaborator). Pregnancy and long term prognosis in women with congenital heart disease. Canadian Institutes of Health Research, $420,000 per annum, 2006 – 2009.

Sermer M (Co-Investigator). The impact of dietary factors on the pathophysiology of gestational diabetes and subsequent type 2 diabetes. Canadian Diabetes Association, $90,863 per annum, 2008 – 2011.

Sermer M (Collaborator). Thrombophilia in Pregnancy Prophylaxis Study. Heart and Stroke Foundation of Canada, $24,000 per annum, 2006 – 2011.

Shaw P, Jurisica I (Principal Investigators); Brown TJ, Letarte M. Fallopian tube epithelial cells as a source of serous cancer in BRCA mutation carriers. Department of Defense U.S. Army Operating Grant, $US 195,000 per annum, 2007-2010.

Shah P, Shah V, Ohlsson A, Murphy KE, McDonald S, Allen V, Hutton E, Newburm-Cook, C (Co-Investigators). Systematic reviews of determinants and effectiveness of primary preventive interventions for low birth weight, and preterm birth. Canadian Institutes for Health Research, $100,000, 2008 – 2009.

Shah P (Principal Investigator), Co-Investigators: Ohlsson A, Shah V, Murphy K, Hutton E, Beyene J, Frick C, Co-Applicants: Allen V, McDonald S, Newburn-Cook C, Scott F. Systematic reviews of determinants and effectiveness of primary preventive interventions for low birth weight, and preterm birth. Canadian Institutes of Health Research, $ 100,000, 2007 – 2008.

Shaw, P. (Principal Investigator) Letarte, M. (Co-Investigator). Characterization of hereditary serous cancer precursors in fallopian tube epithelium. United States Army, $350,000 total, $116,666 per annum, Operating Grant, 2006 – 2009.

Shier RM (Principal Investigator). A multicenter, prospective study of candidate prophylactic HPV -16/18 VLP Vaccine formulated with SBAS4. Experimental vaccine number MEDI-517. A phase IIB trial. Glaxo SmithKline Beecham, $324,000, November 2000 – present.

15 Sierra S (Principal Investigator). Genomic profiling of endometrial biopsies in recurrent implantation failure and recurrent pregnancy loss: An application of micro array technology. Physicians’ Services Incorporated Foundation, $38,500, 2007 – 2009.

Sierra S (Principal Investigator). Molecular array of the endometrium in women with recurrent early pregnancy loss and in women with recurrent implantation failure. Physicians’ Services Incorporated Foundation, $36,500, 2008 – 2010.

Siu KM (Principal Investigator), Colgan T. Discovery, identification, and verification of novel biomarkers in head and neck cancer. Canadian Institutes of Health Research (CIHR). Grant, $126,764 per annum, 2008 – 2010.

Siu KM (Principal Investigator), Romaschin A, Colgan T. Biomarker discovery, identification and verification using tissue proteomics in an endometrial cancer model. National Cancer Institute of Canada, CCS Research Grant, $750,000, $149, 210 per annum, 2005 – 2010.

Sled JG (Principal Investigator); Adamson SL, Langille BL, Kingdom J (Co-Investigators). Three-dimensional quantification of the placenta vascular tree: Relationship with normal and abnormal fetal growth and hemodynamics. Heart and Stroke Foundation of Canada, Grant-in- Aid Program, $132,171 total, $65,283 first year, $66,888 second year, 2006 – 2008.

Stewart DE (Principal Investigator), DesMeules M, Diaz-Granados N, McDermott S, Rondon M, Posada Villa J, Saavedra J. Assessing the feasibility to measure and compare gender-sensitive mental health indicators in Peru, Colombia and Canada. Canadian Institutes of Health Research, $75,000, January 2006 – January 2008.

Stewart DE, Diaz-Granados N. Health indicator research. Public Health Agency of Canada, $9,900, June 2006 – March 2008.

Sutandar M, Paek W. Survey of menstrual cycles: The incidence of menorrhagia and its impact in the workforce. The Canadian Foundation for Women’s Health Award, $2000, 2008.

Sword W (Principal Investigator), Watt SM, Krueger PD, Thabane L, Farine D, Kurtz-Landy CM (Co-Investigators). Postpartum health and service use: Does delivery method matter? Canadian Institutes of Health Research, $620,545, $124,109 per annum, 2005 – 2009.

Tremblay L, Ternamian A (Principal Investigators), Tyrwhitt J. Interdisciplinary collaborative robotic automated port application research. Department of Keniseology, the Division of Gynecologic Endoscopy and the Department of Research and Knowledge Management at St. Joseph's Health Centre. $5000, 2007 – 2009.

Vohra S, Reilly MC, Dunn M, Vincer M, Wiebe N, Zayack D, Wimmer J. Multicentre randomized trial of HeLP (heat loss prevention) in the delivery room. Canadian Institutes for Health Research, $640,465, 2004 – 2008.

16 Vranic M (Principal Investigator), Matthews SG. Physiological and molecular mechanisms of hypoglycemic counterregulation in diabetic rats. Canadian Diabetes Association, Operating Grant, $$142,500 total, $67,500 (1st yr), $75,000 (2nd yr), 2007 – 2009.

Weksberg R, Chitayat D, Kingdom J, Keating A. Investigation of intrauterine growth restriction by gene expression & DNA methylation profiling. CIHR, $383,883, 2006 – 2011.

Windrim R (Principal Investigator) for the TIPPS Group. TIPPS utility of simulated model in the teaching of invasive fetal procedures.Mount Sinai Hospital Striving for Excellence Fund ($10,000), Matching funds from University of Toronto Department of Obstetrics and Gynaecology ($10,000), Matching funds from the Dean’s Excellence Fund ($20,000), $40,000, 2002 – 2008.

Wolfman, W (Principal Investigator), Kroft, J. Effects of vaginal progesterone on vaginal atrophy, Department of Obstetrics and Gynaecology, Mount Sinai Hospital Research Fund, $2,500, April 2008.

Wolfman W, Clemons M A comparative study of estring and vagifem in the treatment of urogenital atrophy in breast cancer. Canadian Breast Cancer Foundation, $114,876, 2007 – 2009.

Wong H. Laparoscopic hysterectomy vs abdominal hysterectomy: A cost-based analysis, 2008.

Wong H, Moody A.A methodology study to investigate magnetic resonance direct thrombus imaging for assessment of lesion response to standard treatment in endometriosis. Pfizer, 2008.

Yinon Y, Kingdom J (Co-Principal Investigators) Understanding the mechanisms for increased cardiovascular risk in women with a history of severe pre-eclampsia: An assessment of postpartum endothelial function. Resident Research Grant, Physicians’ Services Incorporated Foundation, $20,000, 2008 – 2009.

Yudin M (Principal Investigator). Access to infertility services in Ontario for couples in which one or both partners is HIV-positive. AIDS Bureau, Ontario Ministry of Health and Long-Term Care, $17,635, 2007 – 2008.

Yudin M (Collaborator). Mechanism of aging following exposure to HIV antiretroviral drugs. Canadian Institutes of Health Research (CIHR), $485,586, Emerging Team Grant, 2007 – 2012.

Yudin M (Co-Investigator). Survey to assess the fertility desires and needs of Ontario HIV- positive women of reproductive age. Canadian Foundation for AIDS Research (CANFAR), $79,550, September 2006 – September 2008.

Yudin M (Principal Investigator). The seroprevalence of hepatitis C and course of infection among pregnant women attending a Toronto inner city antenatal care clinic. The Physicians’ Services Incorporated Foundation, $87,500, September 2005 – September 2007.

17 Zandstra P (Principal Investigator), Rogers I, Audet J (Co-Investigators). Integrating analytical and computational proteomics to increase in vitro human blood stem cell output. The Natural Sciences and Engineering Research Council of Canada (NSERC) Collaborative Research and Development (CRD) program, $360,000, January 2006 – December 2008.

18 2008-2009

RESEARCH GRANTS AND INVESTIGATIONS

PI=Principal Investigator; CI=Co-Investigator

Adamson SL (PI). Cardiovascular phenotyping in embryonic and newborn mice. CIHR, Equipment and Maintenance Program, $122,109 ($81,984 per annum Equipment + $8,025 per annum Operating), 2005 – 2010.

Adamson SL (PI), Al-war R, Aubin RJ, Boyd S, Mak T, McKerlie C, Nagy A, Roder J, Rossant J, Stanford W, Dick J, Dirks P, Drucker D, Gallinger S, Grynpas M, Hakem R, Henderson J, Henkelman RM, Hui C, Khokha R, McInnes R, McPherson J, Neel B, Osborne L, Post M, Quaggin S, Vidal S, Woodgett J, Yucel Y, van der Kooy D. (CIs). The CMHD: An integrated and regional platform for mouse models of human disease. Canadian Foundation for Innovation, Infrastructure Grant, Leading Edge Fund (LEF), $7,341,094 ($1,835,273 per annum), 2009 – 2012.

Adamson SL (PI), Bocking AD, Caniggia I, Casper R, Jurisicova A, Challis J, Kingdom JC, Langille BL, Lye SJ, Rossant J (CIs). Development and Fetal Health. Canadian Institutes of Health Research, Group Program, $1,876,250 ($375,250 per annum), 2005 – 2010.

Adamson SL (PI), Casper R, Caniggia I (CIs). Infrastructure to study the etiology of pregnancy complications. Canadian Foundation for Innovation/Ontario Research Fund, Infrastructure Grant, Leaders Opportunity Fund (LOF), $390,545 ($306,170/1sty, $45,320/2ndy, $39,055/3rdy), 2007 – 2010.

Adamson SL (PI), Nagy A (CI). Role of placental VEGF-A and FLT1/sFLT1 in placental vascularity, fetal growth, and maternal function in mice. Canadian Institutes of Health Research, Operating Grant, $1,028,010 ($205,602 per annum), April 1,2009 – March 31, 2014.

Adamson SL (PI), Rossant J (Co-PI), Osborne L, Bruneau BG (CIs). Generation and physiological analysis of genome-wide mutations in mice. Canadian Institutes of Health Research, Operating Program, $1,293,687 ($250,909 per annum + $39,142 Equipment). 2004 – 2009.

Alarab May (PI). Drutz HP (Co-I) Expression of modulators of collagen and elastin remodeling in vaginal wall of postmenopausal women with severe pelvic organ prolapse. University of Toronto Faculty of Medicine, Dean’s Fund, New Staff Grant, $10,000, March 1, 2009 – 2014.

Al-Riyami N, Malinowski A, Whittle W (Supervisor) The role of progesetrone in the prevention of preterm birth in women with a cervical cerclage: Evaluation of the effectiveness and mechanism of action. Mount Sinai Hospital Department of OBGYN Research Award, $2,500, 2009 – 2010.

19 Amsalem H, Kingdom J. Decidual neutrophils a novel finding: Their role in second trimester placentation. Physicians’ Services Incorporated, Resident Research Grant. $ 15,000, 2009-2010. Asztalos E, Murphy KE, Hannah ME, Ohlsson A, Delisle MF, Kelly E, Saigal S, Matthews SG, Amankwah A, Lee SK, Ross SJ, Rovet JF, Willan A, Gafni A, Guselle PJ, Sananes R (Co- Investigators). MACS-5 Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study: Five year follow-up. Canadian Institutes of Health Research, # MCT 78775, $3,585,161, 2005 – 2012.

Balki M, Windrim R, Kingdom J, Carvalho J. Optimizing contractility in human myometrium previously exposed to oxytocin: An in-vitro approach to improving treatment options for primary post-partum hemorrhage in laboring women. Canadian Anaesthesia Society Research Fund, $30,000, 2008 – 2009.

Balki M (PI), Carvalho JCA, Wax R, Windrim R (CIs). Assessment of critical skills of practicing anesthesiologists with high-fidelity obstetric anaesthesia simulation. MSH UHN AMO Phase III Innovation Funds, $75,958, 2009 – 2010.

Baratz A (Co-PI) Post-patient Encounter Reflection Tool: (Pertinant): In the Moment Reflection to Enhance Integration of the CanMEDS Roles into the Clinical Setting. SHUTC Academic Trust Fund, $6,800, 2009.

Barrett J (Principal Investigator); Allen AC, Armson BA, Asztalos EV, Farrell SA, Gafni A, Hannah ME, Hutton EK, Joseph KS, Ohlsson A, Okun NB, Ross SJ, Willan AR (Co- Investigators), Zaltz A (Site Coordinator). The Twin Birth Study: A multicentre randomized controlled trial comparing planned Caesarean section with planned vaginal birth for twins at 32- 38 weeks’ gestation. Canadian Institutes of Health Research Grant Award (Randomized Controlled Trials), $8,608,045 total, $956,449 per annum, 2003 – 2011.

Belsham, Denise D. Molecular mechnisms dictating control of neuroendocrine function by estrogen. CIHR, Operating Grant, $752,940, 2009 – 2014.

Benhabib B, Bakirtzian A, Ternamian A. Collaborative project to establish a force sensing platform for safe laparoscopic port creation in minimally invasive surgery. In collaboration with the Department of Clinical Biomedical Engineering, the Department of Kinesiology, Division of Gynecologic Endoscopy and the Department of Research and Knowledge Management at St. Joseph's Health Centre, Toronto, $2,500 and in kind donations. 2007 – 2011.

Bocking AD, Atkinson S (Co-PIs). Canadian Birth Cohort Research Network. MICYRN Seed Grant Competition, $29,096, 2008.

Bocking AD (Project Co-ordinator). Emergency Obstetrical Training (EmOC) in Western Kenya. Developmental Partnerships in Higher Education (DelPHE), British Council, UK, £30,000 per annum, 2009 – 2012.

20 Belik J, (Principal Investigator) Letarte, M. (Co-Investigator). eNOS uncoupling and role of bone morphogenetic protein-9 in the regulation of pulmonary vascular tone during development and following pulmonary hypertension. Heart & Stroke Foundation. $173,812 total, $86,906 per annum, Operating Grant, 2007 – 2009.

Belsham DD (Principal Investigator). Canada Research Chair Award in Neurodocrinology, Tier 2, $500,000 total, $100,000 per annum, July 2004 – June 2009.

Belsham DD. (Principal Investigator). Sensing of peripheral nutrient status by the hypothalamus. Canadian Institutes of Health Research, Renewal, $158,154 per annum, April 2008 – March 2013.

Berger H. Implementation and integration of a Unified Electronic Ultrasound Reporting System and Perinatal Health Care Record. Academic Funding Program Innovation Funds, $120,000, 2009 – 2010.

Berger H (Co-PI).Developmental outcomes of adolescents exposed in utero to corticosteroids - follow up of a randomized controlled study. SickKids Foundation, $151,800, May 2008.

Berger H (PI), Windrim R, Young B, Dalfen A, Macleod A. Is postpartum anemia an independent risk factor for postpartum depression? Canadian Foundation for Women’s Health, Renewal $19,800, 2008 – 2009.

Bernardini M. Clinical and immunohistochemical classification for carcinosarcoma of the uterus. University of Toronto Department of Obstetrics and Gynaecology Research Fund, $10,000, 2009.

21 Bierman AS (PI), Abramson B, Angus J, Anderson G, Bayoumi A, Booth G, Dunn J, Dunn S, Dusek J, Ferris L, Glazier R, Hawker G, Jaakkimainen L, Khanlou N, Krzyzanowski M, Lin E, McDonald L, Manuel D, Moineddin R, Rabineck L, Rhodes A, Rochon P, Stewart DE, Stukel T (Co-Applicants). Ontario Women's Health Report Card: Improving health and promoting equity for the women of Ontario AKA Project for an Ontario Women's Health Evidence-Based Report Card (POWER). Ontario Ministry of Health and Long Term Care, $4,289,300, March 2006 – February 2009.

Bocking AD, (Principal Investigator); Challis JR, Reid G (Co-Investigators). Role of lactobacilli in maternal and perinatal health. Canadian Institutes of Health Research, $96,070 per annum, 2007 – 2012.

Branko B, Lee SK. Initiative for Translational Hypertension Research. University of Alberta, $300,000, 2008 – 2011.

Brown TJ (PI). Identification and functional analysis of nuclear receptor coactivator 4 isoforms expressed during mouse development. NSERC Discovery Grant, $36,500 per annum, 2005 – 2010.

Brown TJ (PI), Jurisica I, Letarte MVT, Shaw PA, Murphy KJ, Rosen B (Co-Investigators). Functional characterization of androgen-altered genes with a putative role during early events in ovarian carcinogenesis. Canadian Institutes of Health Research, Operating Grant, $394, 000 total, $98,500 per annum, 2005 – 2009.

Brown TJ (PI), Ringuette M, Winegarden N. Androgen modulation of TGFβ signaling in ovarian cancer cells. CIHR Operating Grant, $598,000, 2009 – 2013.

Brown TJ (Principal Investigator), Ringuette MJ, Winegarden NA (CIs). Androgen modulation of TGF-beta in ovarian cancer cells. CIHR Operating Grant, $598,992, 2008 – 2012.

Brown TJ, Sweet J, Fleshner N, Winegarden N (Co-Is). Stromal factors promoting prostate cancer progression. Prostate Cancer Foundation, $60,000, 2009 – 2010.

Brown TJ, Sweet J, Kollara A, Winegarden N (Co-PIs). Identification of biomarkers and novel therapeutic targets for testicular germ cell cancers. UHN Foundation Seed Grant, $20,000, 2009.

Bruneau B (Principal Investigator), Chitayat D. Genetic basis of cardiac development and malformation. Canadian Institutes of Health Research, $496,312, 2005 – 2010.

22 Caccia N. Development of a Web-based course covering the basics of common problems in the delivery of sub-specialty care in Paediatric & Adolescent Gynaecology for Obstetrics & Gynaecology Post-Graduate Trainees at the University of Toronto. University of Toronto Information Technology Courseware Development Fund, $5000, 2008.

Caccia N. Development of a Web-based Post-Graduate Medical Education Course in the Fundamentals of Paediatric & Adolescent Gynaecology for Canadian Trainees in Obstetrics & Gynaecology. The Dr. Sheila Cohen Endowment for Women’s Health, NorthYork General Hospital Foundation, $10,000, 2009.

Caccia N. Strategic directions in interprofessional education and interprofessional collaboration in maternity care. HealthForceOntario 2008-2009, Interprofessional Care/Education Fund, $315,563, April 1, 2009 – December 31, 2010.

Cadesky K (PI). AMH as a predictor of ovarian reserve. LifeQuest Center for Reproductive Medicine, General Research Fund, 2009.

Cadesky K (Co-PI). Blood group and incidence of identical twins colab-sperm DNA integrity and birthrate. LifeQuest Center for Reproductive, General Research Fund, 2009.

Caloia D (Co-I). Electronic medical records to improve patient care & public health in rural Kenya. Centers for Disease Control and Prevention, 1 R18 HK000058-01, $1,347,577 US, October 1, 2007 – September 30, 2010.

Caniggia I (Principal Investigator). The role of oxygen in regulating placental development. Canadian Institutes of Health Research Operating Grant, $787,490 total, $156,000 per annum, 2008 – 2013.

23 Caniggia I (Principal Investigator), Jurisicova A (Co-Investigator). The role of Bcl-2 family members in regulating placental cell fate. Canadian Institutes of Health Research Operating Grant, $ 757,050 total, $150,000 per annum, 2008 – 2013.

Casper RF. Can aromatase inhibitors reduce breast density, a biomarker of breast cancer risk, in postmenopausal women taking hormone therapy? Canadian Breast Cancer Foundation, Ontario Region Research Project Grant, $449,889, 2009 – 2012.

Casper RF (Principal Applicant). Genetic polymorphisms in endometriosis. Biodiscovery Toronto, Operating Grant, $25,000, 2007 – 2009.

Casper RF. Investigation of polymorphisms in the fibrinolytic system in women with ovarian cancer. Department of Obstetrics and Gynecology, University of Toronto, $9,500, 2007 – 2008.

Casper RF (Principal Applicant). Optical filters for prevention of circadian rhythm disruption in shift workers. Ontario Centres of Excellence MR grant, $127,500, 2008 – 2009.

Casper RF. The use of aromatase inhibitors to improve sensitivity of MRI in breast cancer detection. Canadian Foundation for Women’s Health, Menopauseandu Grant, $13,500, 2008 – 2009.

Casper RF (Principal Investigator). Brown TJ, Shapiro C. Prevention of circadian rhythm disruption by nocturnal lighting. CIHR, Operating Grant, $107,705.50 per annum, 2008 – 2011.

Casper RF (Principal Applicant), Rogers I (Co-PI) Stem cells for treatment of peripheral vascular disease. BioDiscovery Toronto, Operating Grant, $50,000, 2008 – 2009.

Challis JRG (PI), Bloomfield F, Gluckman P, Matthews S, Newnham J. Control of parturition. Canadian Institutes of Health Research (CIHR) Group in Fetal and Neonatal Health and Development, Operating Grant, $1,050,000 total, $210,000 per annum, 2004 – 2009.

Challis JRG, Lye SJ (Co-PIs). Paracrine controls of human labour. Canadian Institutes of Health Research, $792,120; $158,424 per annum; Operating grant, October 2005 – September 2010.

Challis JRG (PI), Lye SJ, MacCalman CD, Rurak DW, Gibb W. Regulation of prostaglandin synthesis, metabolism and action in pregnancy and parturition. Canadian Institutes of Health Research, Operating Grant, $792,450; $158,490 per annum, October 1, 2004 – September 30, 2009.

24 Chu K, Murphy KE, Whittle W, Shah P, Windrim R. DUC Trial. A randomized controlled trial of immediate vs delayed umbilical cord clamping in preterm infants born between 24-32 weeks’ gestation. University of Toronto Department of Obstetrics and Gynaecology, $4,750, April 2008 – April 2009.

Classens C (PI), Ferguson SE (CI), Urowitz S (CI), Wiljer D (CI). Development of an internet- based support group for sexual problems due to gynecologic cancer. NCIC, $35,000, May 1, 2008 – April 30, 2010.

Compeau C, Chawla A, Tyrwhitt J, Ternamian A, Kroft J, Ambica A. National multidisciplinary collaborative survey on laparoscopic entry.SOGC, CUA, CAGS, Supported by the Division of Gynecologic Endoscopy and the Department of Research and Knowledge Management at St. Joseph's Health Centre, Toronto, $2,500, 2007 – 2010.

Dalton AJ, Aisen P, Sano M (PIs); Percy M (National (Canadian) Coordinator and Surrey Place Centre (SPC) Site Coordinator) plus investigators from 20 other sites; International Multisite Clinical Trial of Vitamin E in Aging Persons with Down Syndrome. National Institute on Aging, National Institute of Child Health and Human Development, and National Center of Complementary and Alternative Medicine (RO1-AGO16381), $10 million overall, $1 million per annum overall, 2008-09 stipend to SPC, $900; 2001 – 2011.

Debrew M, Dubrowski A, Kneebone R, Pittini R, Barrett A, Bello M, Tajirian T, Satterswaite L. A training cascade for Ethiopian surgical and obstetrical care: An interprofessional, educational, leadership and skills training program. DelPHE (Developing Partnerships in Higher Education), British Council Grant, £20,000, 2008 – 2010.

Derzko CM (PI). A Phase III, randomized, double-blind, placebo-controlled, multi-center study of the safety and efficacy of LibiGel for the treatment of Hypoactive Sexual Desire Disorder in surgically menopausal women. BioSante Protocol No TESTW008, Total Operating Budget: $87,074, Total cost per completed subject: $6,715, 2008 – ongoing.

Derzko CM (PI), Josse R (Co-Applicant). A double-blind, randomized, placebo-controlled study assessing the safety and efficacy of DVS SR for the treatment of vasomotor symptoms associated with menopause. Wyeth, Protocol 3151A2-3353-NA, $85,918, Total cost per completed subject $6,701, 2008 – ongoing.

25 Drutz HP (PI). A 12 month double-blind, randomized placebo-controlled multi-centered trial to investigate the efficacy and safety of Vagifem low dose (10ug) 17 Beta estradiol vaginal table) for the treatment of postmenopausal atrophic vaginitis symptoms. Protocol Nu: Vag – 2195. Novo Nordisk, Grant, $13,928, 2007 – 2008.

Drutz HP (PI). A randomized double-blind study to assess the safety and efficacy of Solifenacin (Vesicare®) in comparison to Oxybutynin for overactive bladder patients. Protocol Nu: VES- 001 VECTOR. Astellas Pharma Canada. Grant: $15,130, 2007 – 2008.

Du L, Singhal N, McMillan DD, Aziz K, Lee SK. Impact of (ACoRN) acute care of at risk newborn education program in rural China. Canadian Institutes of Health Research, $180,000; 2008 – 2011.

Easton W, Brookman C, Skelly J. (Co-Is) Optimal management of urinary incontinence in long term care homes in Ontario. MOHLTC NP, $18,500, 2008 – 2009.

Ferguson SE, Urowitz S. Supporting gynaecologic oncology patients with, through, and beyond: Patient education and survivorship at Princess Margaret. Schering-Plough Education Grant, $30,000, January 2009 – January 2011.

Ferguson SE(PI), Urowitz S (Co-PI), Classens C (Co-PI). Development and validation of the modified sexual adjustment and body image scale in women with a diagnosis of gynecologic cancer (SABIS-G). Department of Obstetrics and Gynaecology, University of Toronto, Research award, $5000, 2009.

Fleshner N (PI), Brown TJ, Done S, Jurisica I, Lockwood G, Sweet J (CIs). Identification and characterization of alterations at the stroma-epithelial interface in prostate cancer. Ontario Cancer Research Network (OCRN), Operating Grant, $544,312, 2007 – 2010.

Friedman JM (Principal Investigator), Chitayat D. Canadian Molecular Cytogenetics Platform. Canadian Foundation for Innovation, $4,512,925, 2005 – 2010.

Friedman JM (Principal Investigator), Chitayat D. Identifying human mutations that cause mental retardation. Canadian Institutes of Health Research, $2,498,538, 2005 – 2010.

26 Grimm N, Lee SK. Keeping track of the patient in a resource-limited setting: Pilot implementation of an electronic health record in Tanzania. Canadian Institutes of Health Research, CIHR Doctoral Research Award, $49,667, 2007 – 2009.

Grynpas MG (PI), Adamson SL, Bazett-Jones DP, Brumell JH, Grinstein S, Keeley FW, McKerlie C, Quaggin S, Tenenbaum HC, Zhen M (CIs). Maintenance of the advanced bioimaging centre. CIHR, Maintenance Grant, $563,180 ($112,636 per annum), 2006 – 2011.

Han VKM (PI), Adamson SL, Avison WR, Campbell MK, Gagnon R, Hill DJ, Lee TY, Mann M, Richardson BS, Speechley KN, Thompson RT, Yang K. Fetal growth restriction: Mechanisms and outcomes. CIHR, Healthy Pregnancy for Great Life Beginnings Program, $1,675,006 ($322,271 per annum + $63,650 Equipment), 2005 – 2010.

Hellmann J, Ives-Baine L, Golec L, Lindsay G, Lee KS, Stephens D, Hetherington R. Withdrawal of artificial hydration & nutrition in newborn infants: Determining neonatal nurses' perspectives on the ethical & practical issues in this practice. Paediatrics Consultants Partnership Grants for Creative Professional Activity, The Hospital for Sick Children, $10,000; 2008 – 2009. Hellmann J, Shah P, Lee SK. Death in Canadian Neonatal Intensive Care Units (NICUs): Exploring the ethical determinants. Canadian Institutes of Health Research, $99,698; 2008 – 2010.

Janssen P, Lee SK. Antepartum Care of High Risk Pregnancy Team. Canadian Institutes of Health Research, $213,000, 2008 – 2011.

Jones R (PI), Lye S, Shynlova O. Identification of early triggers of decidual activation in preterm labour. Tommy’s, The Baby Charity, Operating grant, $298,391; $99,464 per annum, November 1, 2008 – October 31, 2011.

Josse R (Principal Investigator), Derzko CM, Rubin L (Co-Investigators). 52 week randomized double-blind, multicenter,mechanistic study with a 24 week open label follow-up to evaluate the

27 effect of AVANDIA on bone in postmenopausal women with type 2 diabetes mellitus. GlaxoSmithKline Protocol ZM2007/00146/00, 2008 – 2010.

Jurisica Igor, Oza Amit M (Principal Investigators), Colgan Terence J, Jurisicova Andrea, Kislinger Thomas (Co-Investigators). Diagnostic and prognostic biomarkers for epithelial ovarian cancer. Canadian Institutes of Health Research, Operating Grant, $643,742, 2008 – 2012.

Jurisicova A. Canada Research Chair. CIHR, $175,000, July 1, 2008 – June 30, 2013.

Jurisicova A. Imaging equipment for Center for Maternal and Fetal Health. CRC/CFI – Infrastructure grant, $861,080, 2008.

Jurisicova A. Importance of harakiri in regulation of oocyte and embryo survival. Canadian Institutes of Health Research, New Investigator Salary Support $50,000 per annum, July 1 2003 – December 31, 2008.

Jurisicova A (PI) Molecular pathways of oocyte aging. CIHR, Catalyst Grant: Pilot Projects in Aging, $50,000, January 1, 2009 – December 31, 2009.

Jurisicova A. Mouse models of ovarian cancer. Grant Miller Research Foundation, $20,000 per annum, 2008.

Kingdom J (PI) “HEPRIN” trial. Physicians’ Services Inc., $122,000, 2007 – 2010.

Kingdom JCP (PI). Villous trophoblast turnover. Canadian Institutes of Health Research Award, $532,888, 2006-2010.

Kingdom J, Czikk M (Co-PIs). Identification of candidate pathways in intrauterine growth restriction: Important first step towards disease etiology. Physicians’s Services Incorporated Foundation, Resident Research Grant, $19,560, 2008 – 2009.

28 Kingdom J, Librach C (Co-Applicants). A prospective study on the prediction of preeclampsia using an HLA-G gene mutation. Canadian Institutes of Health Research, $148,221, Sept 2008 – August 2011.

Kingdom J, Sled JG (Co-PIs) Three dimensional quantification of the placental vascular tree: Relationship with normal and abnormal fetal growth and hemodynamics. Heart and Stroke Foundation of Canada, $132,171, 2006 – 2008; Renewal $153,042, 2008 – 2010.

Kingdom J, Walker M, Rodger, M (CIs). TAPP: Thrombophilia and Placental Pathology. Heart and Stroke Foundation of Canada, $340,000, 2005 – 2008.

Lambe EK (PI). Cellular and molecular mechanisms underlying development and plasticity of prefrontal attention circuitry. Canadian Institutes of Health Research, $718,025 total; $143,605 per annum, 2008 – 2013.

Lambe EK (PI) Mechanism of aberrant attention circuitry in a mouse model of Fragile X mental retardation. Scottish Rite Charitable Foundation, New Investigator Operating Grant, $105,000 total; $35,000 per annum; 2008 – 2011.

Lambe EK (PI). Signal transduction and adult cortical network activity. National Science and Engineering Research Council (NSERC) Discovery Grant (Operating), $178,125 total ; $35,625 per annum, 2007 – 2012.

Lee KS, Gibbins S, Aliwalas L. Comparison of tutor versus multi-media computer disk for teaching the Neonatal Pain, Agitation and Sedation Scale (N-PASS). Pediatric Consultants Educational Research Grant, $5,000, 2008.

Lee P (PI), Marcoux V. Web-based Teaching Modules for Urogynecology Residents. SHUTC Academic Trust Fund, Grant, $5,000, July 2008 – 2009.

Lee SK. Maternal Infant Care (MICare) Research. Ontario Ministry of Health & Long Term Care, $15,000,000, 2009 – 2013.

Lee SK, Armson A (PIs), Allen VM ; Andruschak J, Attenborough R, Bottomley J, Bujold E, Crane JM, Da Silva OP, Dumont AM, Frick CL, Heaman MI, Janssen PA, Klein MC, Liu S, Moutquin JM, Murphy P, O'Brien BAC, Ohlsson A, Pasquier JC, Platt RW, Sauve RS, Von Dadelszen P, Walker MC. World Health Organization Global Survey for Maternal and Perinatal Outcomes in Canada. $500,000, June 1, 2007 – May 31, 2009.

Lee SK, Armson BA, Aziz K, Baker GR, Barrington K, Dendukur N, El-Hajj MO, Haywoos RS, Joseph KJ, Liston RM, Magee LA, Ohlsson A, Saigal S, Sauve RS, Shaw NT, Skarsgard ED, Steven BJ. CIHR Team in Maternal Infant Care – Translating Knowledge into Improved Care. Canadian Institutes of Health Research [Canadian Neonatal Network], $4,902,460, 2008 – 2013.

Lee SK (PI), Armson BT, Khalid A, Baker GR, Barrington KJ, Dendukuri N, El-Hajj MO, Hayward RSA, Joseph KS, Liston RM, Magee LA, O'Campo P, Ohlsson A, Saigal S, Sauve RS,

29 Shaw NT, Skarsgard ED, Stevens BJ (Co-Investigators). CIHR Team in Maternal Infant Care, $1,727,068, October 1, 2008 – September 30, 2013.

Lee SK (PI), Aziz K, Baker GR, Barrington K, Clarke MCW, Cronin CM, Dunn MS, James A, Langley J, Lee DS, Lefebvre F, Merchant P, Ohlsson A, Orrbine E, Peliowski A, Sankaran K, Seshia M, Shaw NT, Synnes AR, Tan-Dy CR, Walker CR, Whyte RK. National health partnership for reducing infections in NICU. Canadian Institutes of Health Research, $ 99,999.00, 2005 – 2008.

Lee S, Armson A, Allen V, Andruschuk J, Attenborough R, Bottomley J, DaSilva O, Frick C, Heaman M, Murphy P, Pasquier J-C, Bujold E, Crane J, Dumont A, Janssen P, Klein M, Liu S, Moutquin J-M, O'Brien B, Ohlsson A, Platt R, Sauve R, von Dadelszen P, Walker M. Survey of mode of delivery and maternal and perinatal outcomes in Canada. CIHR/WHO, $250,000, 2007 – 2009.

Leslie K, Schreiber M, Lieff S, Pittini R, Reeves S. Utilizing teaching evaluations to promote faculty development in teaching. Undergraduate Medical Education (UME) Curriculum Renewal Fund, Ministry of Health and Long-Term Care Curriculum Renewal Fund, MOHLTC/UT, $19,630, 2008 – 2010.

Leslie K, Reeves S, LeBlanc V, Lingard L, Dubrowski A, Morgan P, Naik V, Ballon B, Satterthwaite L, Robb A, Silver I, Pittini R, Cop S, Bandali K. Faculty Development for Simulation for Clinical Teaching and Learning. NESCTL (Network for Excellence in Clinical Teaching & Learning) Grant, $83,990, 2008 – 2010.

30 Levitan RD (Principal Investigator), Davis C, Kennedy JL, Loucks EB, Matthews SG, Meaney MJ, Soares CD, Steiner MA (Co-Investigators). Longitudinal study of food reward and obesity in young children: The role of gene-environment interaction. Canadian Institutes of Health Research, Operating Grant, $780,390, 2008 – 2013.

Levitan RD (Principal Investigator), Matthews SG. Sociobiological and genetic predictors of the stress response in chronic major depression. CIHR, Operating Grant, $200,000 total, $100,000 per annum, 2007 – 2009.

Leyland N (PI). FAST Trial Multicentre Trial of Intrauterine Ultrasound-Guided Radio- Frequency Ablation Of Myomata. GYNESONICS, $2,500,000, 2009 – 2011.

Librach CL, Kingdom JC (PIs). Prediction of preeclampsia using an HLA-G gene single nucleotide polymorphism (SNP). Canadian Institutes of Health Research, Operating Grant, $266,337, 2008 – 2011.

Lilge L (PI), Derzko C (Co-Applicant). Short term evaluations of breast tissue change in postmenopausal women using otpical breast spectroscopy (OBS). Princess Margaret Hospital Foundation – Weekend Walkers Breast Cancer Innovation Fund, $84, 655 total, April 2008 – March 2010.

Liu F (PI) Fyles A, Bezjak A, Bristow R, Catton P, Gospodarowicz M, Jurisica I, Jaffray D, Kelly S, Wong S, Wouters B (Co-Applicants). Research Excellence in Radiation Medicine for the 21st Century. Canadian Institutes of Health Research and Cancer Care Ontario Strategic Training Program Grant 200301STP Competition. $1,950, 000, 2009 – 2015.

Lye SJ. Fetal, neonatal and maternal health. CIHR, Tier 1 Canada Research Chairs Program, Operating grant, $1,400,000; $200,000 per annum, July 1, 2008 – June 30, 2015.

Lye SJ (PI), Adamson SL, Challis JRG, Danska J, Matthews S, Osborne L, Pennell C, Rossant J (CIs). A murine model to investigate the mechanisms underlying DOHaD. Canadian Institutes of Health Research, Operating grant, $373,673, $124,558 per annum, October 1, 2006 – September 30, 2009.

Lye, SJ (PI), Adamson L, Matthews SG. Pennell CE (Co-Investigators). A murine model to investigate the mechanisms underlying DOHaD. CIHR, Operating Grant, $910,852, 2009 – 2014.

Lye SJ (Principal Investigator), Beilin L, Briollais L, Challis J, Doherty D, Matthews S, Newnham J, Ozcelik H, Palmer L, Pennell C, Siminovitch K, Stanley F, van Eekelen J, Zubrick S. Gene environment interactions underlying the developmental origins of health and disease. Canadian Institutes of Health Research, Operating grant, $408,828 total, $136,276 per annum, April 1, 2007 – March 31, 2010.

31 Lye SJ (Principal Investigator). Myometrial programming: A new concept underlying the control of myometrial contractility during pregnancy. Canadian Institutes of Health Research $727,080 total, $145,416 per annum, Operating grant, October 1, 2005 – September 30, 2010.

Magee L,Von Dadelszen P, Asztalos E, Logan S, Armson A, Gafni A, Gruslin A, Melewa M, Hutton E, Lee S, Moutquin JM, Murphy K, Rey E, Ross S, Singer J. CHIPS Control of Hypertension In Pregnancy Study. Canadian Institutes for Health Research, $4,135 245, 2008 – 2013.

Matthews SG (Principal Investigator). Maternal stress in pregnancy programs endocrine function and behaviour in adult offspring. Operating Grant, Natural Sciences and Engineering Research Council of Canada (NSERC), $237,500 total, $47,500 per annum, 2006 – 2011.

Matthews SG (Principal Investigator). Multidrug resistance in pregnancy. Canadian Institutes of Health Research, Operating Grant, $637,980 total, $127,596 per annum, 2005 – 2010.

Matthews SG. Trangenerational effects of antenatal glucocortocoid treatment: Mechanisms of programming. CIHR, Operating Grant, $479,331, $159,777 per annum, 2009 – 2012.

Matthews SG, Meaney M (Co-Directors). Maternal adversity, vulnerability & neurodevelopment. Canadian Institutes of Health Research, Program Grant, $3,750,000 total, $750,000 per annum, 2003 – 2009.

Matthews SG (PI), Szyf M (Co-Investigator).Transgenerational effects of antenatal glucocorticoid treatment: Mechanisms of programming. Canadian Institutes of Health Research, Operating Grant, $100,000, 2008 – 2009.

Matthews, SG (PI), Szyf M (CI). Transgenerational effects of antenatal glucocorticoid treatment: Mechanisms of program. CIHR, Operating Grant, $479,331, 2009 – 2012.

Maxwell C (PI), Glanc P (Co-PI). Can the 15 week transvaginal ultrasound decrease the number of examinations required for the fetal anatomic evaluation in obese pregnant women? Ontario Ministry of Health Mount Sinai Hospital/University Health Network Academic Medical Organization Innovation Fund (IF). $85,891, 2009 – 2011.

32 McCulloch C(PI) , Brown TJ, Ringuette M. Bone sialoproteins in skeletal metastasis. CIHR, Operating Grant, $430,822, 2008 – 2011.

McGeer AJ (Principal Investigator), Allen VM, Bujold E, Coleman BL, Drews SJ, Johnstone J, Lee BE, Levy M, Loeb MB, Louie M, Manos SH, Mcneil SA, Money DM, Murphy KE, Taylor G, Zahariadis G. Outcomes of Pandemic Influenza in Pregnancy (OPIP). CIHR, Catalyst Grant: Pandemic Outbreak Research Response, $153,011, October 1, 2009 – September 30, 2010.

McKerlie C (PI), Adamson SL, Aubin JE, Hu J. Hu CC, Nagy A, Post M, Rossant J, Stanford WL, Vidal SM (CIs). Canadian mouse mutant repository: A core resource for mouse models of human disease. CIHR, Resource Grant Program, $519,036 ($100,009 per annum + $18,991 Equipment), 2006 – 2011.

Meyer JH (Principal Investigator), Houle S, Stewart DE, Wilson AA (Co-Applicants). Neurochemical aspects of depression in women: Monoamine Oxidase A in the postpartum period. Canadian Institutes of Health Research. $309,000, April 2007 – March 2010.

Miranda V, Lovatsis D. Randomized controlled trial of cystocele plication risks (CPR Trial). MSH Research Fund, $6,150, April 2009.

Murphy KJ (Principal Investigator), Bloom JA (Co-Investigator). Evaluation of the role of human papillomavirus and P-16 testing in cervical cancer screening. Giovanni and Concetta Guglietti Family Cancer Fund, Cervix, PMH Foundation, Cervical Cytology Grant, $200,000, 2006 – 2010.

Nagy A, Piret J, Bhatia M, Eaves C (Project Leaders), Humphries K, Karsan A, van der Kooy D, Lansdorp P, Lye S, Marra M, Rancourt D, Rossant J, Zandstra P. Derivation and primary characterization of human ES cells using defined and xeno-free conditions. Networks of Centres of Excellence (NCE), $289,803 total, $96,601 per annum, Operating grant, September 1, 2005 – August 31, 2008.

Nam, RK (Principal Investigator), Bell D, Chin J, Narod S, Lkotz L, Izawa J, So A, Aprikian A, Trachtenberg J, Jewett M, Toi A. Cross-Canada assessment of a new nomogram prediction tool for prostate cancer screening. National Cancer Institute of Canada (NCIC), $462,084 total, ($160,796: 2006 – 2007; $150,644: 2007 – 2008; $150,644: 2008 – 2009:), 2006 – 2009.

Narod, Steven. BRCA1, BRCA2 and ovarian cancer survivorship. Canadian Cancer Society Research Grant. 2009/2010: $131,648; 2010/2011: $86,394, 2009 – 2011.

Narod, Steven. Risk factor analysis of hereditary breast and ovarian cancer. Canadian Breast Cancer Research Alliance Operating Grant. $297,900 per annum, $1,489,500 total, 2009 – 2014.

Narod S (PI), Eisen A, Foulkes W, Ghadirian P, Kim-Sing C, Robidoux A, Rosen B. (Co-Applicants). Risk factor analysis of hereditary breast and ovarian cancer. CBCRA, Grant #015340, $1,485,000, July 2004 – June 2009.

Narod SA (PI), Ghadirian P, Malkin DD (Co-Investigators). Genetic susceptibility to esophageal cancer. Canadian Institutes of Health Research, Operating Grant, $552,132, 2008 – 2011.

Narod S (PI), Miller A, To T. Canadian National Breast Screening Study (NBSS): Final analysis. CBCRA, Grant #: 017459, $314,363, September 2006 – September 2009.

Nevo, Ori. The role of sFlt-1 heterodimers in the pathogenesis of preeclampsia. Dean's Fund New Staff Grants, University of Toronto, $10,000, 2009.

Olson D, Lee SK. Preterm birth and healthy outcomes. AHFMR, $5,000,000, 2008 – 2013.

Olson D (Principal Investigator), Bocking AD. Preterm birth and healthy outcomes. Alberta Heritage Foundation for Medical Research (AHFMR), $1,000,000 per annum, 2008 – 2012.

Palmer L (PI), Pennell C, Beilin L, Newnham J, Lye S, Smith D. A genome-wide search for genes underlying the developmental origins of health and disease. National Health and Medical Research Council (Australia), Operating Grant, $897,878; $299,293 per annum, January 1, 2009 – December 31, 2011.

Pedersen D, Lopez V, Sharma B, Piazza M, Chamindra Weerackody LP, Kirmayer LJ, Rousseau C, Young A, Guzder J, Stewart DE (Co-Investigators); Anckerman S, Flores MA, deVillagran M, Garcia HA, Chavez C, Jordans M, Kohrt B, Thapa S, Tol W, Castillo H, Cueva G, Mendoza M, Matos L, Calderon D, Rivera M, Fernando S, Amarasuriya H, Fernando S, Zarate CAJ (Co- Applicants). Political violence, natural disasters and mental health outcomes: Developing innovative health policies and interventions. International Development Research Centre. $1,599,542, January 2007 – January 2011.

Ray JG. InterPreg Study. Canadian Institutes of Health Research. Operating Grant, $47,000 per annum, 2005 – 2010.

Ray JG. New Investigator Award. Canadian Institutes of Health Research. $250,000, 2005- 2010. Retnakaran Ravi R, Connelly Philip W, Floras John S, Hanley Anthony J,

Sermer Mathew, Zinman Bernard (Principal Investigators). The early natural history of cardiovascular disease at 4-years postpartum in young women with varying degrees of glucose intolerance in pregnancy. Canadian Institutes of Health Research, Operating Grant, $100,000, 2008 – 2009.

Roberts SW, Loh A, Feigenbaum A, Weiss S, Marcon C, Goldfarb C, Berall G, Bradley E, Brian J, Freeman N, Atkinson A, Taylor M, Stinson J, Mitchell S, Green P, Chitayat D. Autism speaks. Autism Treatment Network: Cooperative Multi-Center Program for Research and Treatment of Autism, $408,000, 2008 – 2010.

Roberts SW, Loh A, Feigenbaum A, Weiss S, Marcon C, Goldfarb C, Berall G, Bradley E, Brian J, Freeman N, Atkinson A, Taylor M, Stinson J, Mitchell S, Green P, Chitayat D. Funding of an autism intervention research network for physical health. Health Resources and Services Administration, $400,882, 2009 – 2011.

Rogers I (PI). Stem cell therapy for type 1 Diabetes. MaRS Innovations, $68,000, 2009 – 2010.

Rogers I (PI). Stem cells and Diabetes. BioDiscovery Toronto, $50,000, 2008 – 2009.

Rosen B. Canadian synoptic reporting in Canada. Canadian Partners against Cancer, $243,000 per annum, 2008 – 2010.

Rossant, Janet. Lineage development in the mouse blastocyst. CIHR, Operating Grant, $1,012,210, 2009 – 2014.

Rossant J (PI), Adamson SL, Aubin JE, Cordes SP, Osborne LR, Quaggin SE, Roder JC, Stanford WL, Vallis KA, Van Der Kooy DJ, Vidal SM (Co-Investigators), Centre for Modeling Human Disease. Canadian Institutes of Health Research, Group Program, $2,532,330 ($506,466 per annum + $15,000 Equipment), 2004 – 2009.

Sellers T (PI), Narod S (Co-Applicant). Haplotype-based genome screen for ovarian cancer loci. NIH/NCI, Grant #: R01 CA114343-01 A2, $50,000 US, March 2007 – February 2010.

Sermer M (PI). Food Frequency Questionnaire Validation Study – MIREC. Toronto Health Canada, $9999 per annum, 2009 – 2010.

35 Sermer M. (Co-PI) Hemodynamics and hormonal changes in pregnant women with heart disease; Understanding the effects of pregnancy on the diseased heart. Heart and Stroke Foundation of Canada, $74,000 per annum, 2006 – 2008.

Sermer M (CI). Maternal and Infant Research on Oxidative Stress. CIHR, $4,704, 2007 – 2009.

Sermer M (PI). Maternal Infant Research on Environmental Chemicals (MIREC), CIHR, $160,000 per annum, 2008 – 2009.

Sermer M (Co-Principal Investigator). Neurodevelopmental outcome in offspring of women with heart disease. Heart and Stroke Foundation of Canada, $123,080 per annum, 2006 – 2009.

Sermer M (Collaborator). Pregnancy and long term prognosis in women with congenital heart disease. Canadian Institutes of Health Research, $420,000 per annum, 2006 – 2009.

Sermer M (CI). The Canadian Healthy Infant Longitudinal Development (CHILD) Study. CIHR, $347,549.00/per annum, 2007 – 2016.

Sermer M (CI). The early natural history of cardiovascular disease at 4 years postpartum in young women with varying degrees of glucose intolerance in pregnancy. Heart and Stroke Foundation of Canada, $59, 836.00/first year, 2009 – 2012.

Sermer M (Collaborator). Thrombophilia in Pregnancy Prophylaxis Study. Heart and Stroke Foundation of Canada, $24,000 per annum, 2006 – 2011.

36 Sierra S (Principal Investigator). Microarray analysis of the endometrium in women with recurrent early pregnancy loss and in women with recurrent implantation failure. Physicians’ Services Incorporated Foundation, $36,500, 2007 – 2010.

Siu L (PI), Milosevic M, Brade A, Brandwein J, Chen EX, Fyles A, Haider M, Hedley D, Hirte H, Hotte S, Jurisica I, Kavsak P, Liu G, Macri J, Metser U, Milosevic M, Minden M, Moore MJ, Moran M, Oza A, Reilly R, Seymour L, Tsao M-S, Yee K (Co-Applicants). Early clinical trials of new anti-cancer agents with Phase I emphasis (U01). National Cancer Institute (USA) NIH/NCI Investigational New Drug Phase I Consortium Grant #: 1 U01 CA132123-01, $ 3,141,915 USD, February 2008 – January 2013.

Skarsgard ED, Lee SK, Bouchard S, Kim PCW, Laberge J-M, McMillan DD, Von Dadelszen P, Yanchar NL. Canadian perinatal surgery network (CAPSNET): Establishing best perinatal practices for gastroschisis and congenital diaphragmatic hernia using a Canadian dataset. $221,280, October 1, 2004 – September 30, 2008.

Sled JG (PI), Adamson SL, Langille BL, Kingdom J (CIs). Three dimensional quantification of the placenta vascular tree: Relationship with normal and abnormal fetal growth and hemodynamics. Heart and Stroke Foundation of Canada, Grant-in-Aid Program, $153,042 ($76,521 per annum), 2008 – 2010.

Sloan E (PI) Driver H, Maxwell C, Ryan C, Finan E (CIs). Ontario Ministry of Health Mount Sinai Hospital/University Health Network Academic Medical Organization Innovation Fund (IF). obstructive sleep apnea during pregnancy in obese women: Impact on fetal development, $108,850, 2009 – 2011.

Spitzer RF. Development of a partograph algorithm for use on PDAs in a global context. & Evaluation of the ALARM International Program in Kenya. Mount Sinai Department of Obsterics and Gynaecology Research Fund, $5000, 2009.

Stevens BJ (PI), Barwick MA, Campbell F, Chambers CT, Cohen JS, Cummings G, Estabrooks CA, Finley GA, Johnston C, Kavanagh PM, Latimer MA, Lee SK, Lemay S, Mcgrath PJ, Rashotte JM, Rosmus CB, Sawatzky-Dickson D, Scott SD, Sidani S, Stinson JN, Stremler RL, Synnes AR, Taddio A, Villeneuve E, Warnock FF, Willan AR, Yamada J (Co-Investigators). Translating Research on Pain in Children (TROPIC) Study, CIHR, Operating Grant, $810,472, 2007 – 2010.

37 Stevens B, Lee SK. CIHR Team in Children’s Pain. Canadian Institutes of Health Research. $4.7 million, 2006 – 2011.

Theriault B (PI), Gallie B (Supervisor), Bernardini M (Collaborator). Expression profiling of the novel cancer gene KIF14 in ovarian cancer. DOD-CDMRP, US Department of Defence Congressionally Directed Medical Research Program, Grant # OC080083, $100,000 per annum, March 2009 – March 2012.

Thombs B (PI), Stewart DE (CI). A systematic review of screening for psychosocial factors in breast cancer. Canadian Breast Cancer Research Alliance, $200,000, June 2009 – June 2010.

Tremblay L, Ternamian A (Principal Investigators), Tyrwhitt J. Interdisciplinary collaborative robotic automated port application research. Department of Kinesiology, the Division of Gynecologic Endoscopy and the Department of Research and Knowledge Management at St. Joseph's Health Centre, Toronto, $5000 and in kind donations, 2007 – 2011.

Von Dadelszen P (PI), Nsermino JM, Douglas MJ, Gruslin AMR, Lee SK, MacNab YC, Magee LA, Moutquin JM, Ouellet A, Russell JA, , Graeme N, Walley KR. PIERS (preeclampsia integrated estimate of risk for mothers): Validation across conditions and clinical settings. CIHR, Operating Grant, $705, 649, July 1, 2007 – June 30, 2010.

Vranic M (Principal Investigator), Matthews SG (Co-Investigator). Physiological and molecular mechanisms of hypoglycemic counterregulation in diabetic rats. Canadian Diabetes Association, Operating Grant, $142,500 total, $67,500 (1st yr), $75,000 (2nd yr), 2007 – 2009.

Weksberg R, Chitayat D, Kingdom J, Keating S. Investigation of intrauterine growth restriction by gene expression & DNA methylation profiling. CIHR, $383,883, 2006 – 2011.

Windrim R(PI), Seaward PGR, Lausman A, Pittini R (CIs). Development of a training program to teach teachers how to implement a simulation-based curriculum in obstetric emergencies for interprofessional teams. University of Toronto, $14,810, 2008.

Wolfman, W (Principal Investigator), Kroft, J. Effects of vaginal progesterone on vaginal atrophy, Department of Obstetrics and Gynaecology, Mount Sinai Hospital Research Fund, $2,500, April 2008.

Wolfman W, Clemons M A comparative study of estring and vagifem in the treatment of urogenital atrophy in breast cancer. Canadian Breast Cancer Foundation, $114,876, 2007 – 2009.

Wong H. Laparoscopic hysterectomy vs abdominal hysterectomy: A cost-based analysis, 2008.

Wong H, Moody A.A methodology study to investigate magnetic resonance direct thrombus imaging for assessment of lesion response to standard treatment in endometriosis. Pfizer, 2008.

Yudin M (Collaborator). Mechanism of aging following exposure to HIV antiretroviral drugs. Canadian Institutes of Health Research (CIHR), $485,586, Emerging Team Grant, 2007 – 2012.

Yudin M (PI). Canadian physician attitudes regarding pregnancy, reproductive care choices, and access to fertility services among HIV-positive individuals or couples. Canadian Foundation for AIDS Research (CANFAR) Grant, $23,172.62, 2009 – 2010.

Yudin M (CI). Ontario HIV Pregnancy Planning Initiative: An evidence-based province-wide multidisciplinary program assisting people living with HIV with fertility and pregnancy planning. Ontario HIV Treatment Network (OHTN) Capacity-Building Grant, $50,000, 2008 – 2009.

Zandstra P (Principal Investigator), Rogers I, Audet J (Co-Investigators). Integrating analytical and computational proteomics to increase in vitro human blood stem cell output. The Natural Sciences and Engineering Research Council of Canada (NSERC) Collaborative Research and Development (CRD) program, $360,000, January 2006 – December 2008.

39 2009-2010

RESEARCH GRANTS AND INVESTIGATIONS

PI=Principal Investigator; CI=Co-Investigator

Adamson SL (PI). Cardiovascular phenotyping in embryonic and newborn mice. CIHR, Equipment and Maintenance Program, $122,109 ($81,984 per annum Equipment + $8,025 per annum Operating), 2005 – 2010.

Alarab M (PI). Expression of modulators of collagen and elastin remodeling in vaginal wall of postmenopausal women with severe pelvic organ prolapse. University of Toronto Faculty of Medicine, Dean’s Fund, New Staff Grant, $10,000, March 1, 2009 – 2014.

Alarab, M (PI). Expression of modulators of collagen and elastin remodeling in vaginal tissue of premenopausal women with severe pelvic organ prolapse, Physicians’ Services Incorporated Foundation, $ 28,600, December 2009 – December 2010.

40 Al-Riyami N, Malinowski A, Whittle W (Supervisor) The role of progesetrone in the prevention of preterm birth in women with a cervical cerclage: Evaluation of the effectiveness and mechanism of action. Mount Sinai Hospital Department of OBGYN Research Award, $2,500, 2009 – 2010.

Amsalem H, Kingdom J. Decidual neutrophils a novel finding: Their role in second trimester placentation. Physicians’ Services Incorporated, Resident Research Grant. $ 15,000, 2009-2010.

Arbuckle T, Fraser WD (PIs); Weber JP, Legrand M, Kumarathasan P, Vincent R, Luo Z-C, Ettinger A, Platt R, Mitchell G, Cockell K, Villeneuve M, Tittlemier S, Julien P, Avard D, Hidiroglu N, Weiler H, LeBlanc A (CIs); von Dadelszen P, Helewa M, Sermer M, Foster WG, Ross G, Fredette P, Smith G, Walker M, Shear R, Dodds L (Site Investigators). Maternal-Infant Study on Environmental Chemicals: The MIREC Study. CIHR, $35,000 per annum. 2010 – 2011.

Asztalos E, Murphy KE, Hannah ME, Ohlsson A, Delisle MF, Kelly E, Saigal S, Matthews SG, Amankwah A, Lee SK, Ross SJ, Rovet JF, Willan A, Gafni A, Guselle PJ, Sananes R (Co- Investigators). MACS-5 Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study: Five year follow-up. Canadian Institutes of Health Research, # MCT 78775, $3,585,161, 2005 – 2012.

Barbera L (PI), Gien L, Khalifa M (Co-Investigators). Vulvar carcinoma: A population-based analysis. Canadian Cancer Society Research Institute, $352,243 total; $152,915 first year, $140,445 second year, $58,883 third year, 2010 – 2013.

Barrett J (Co-PI) Massage therapy for hospitalized pregnant women: A pilot study. Holistic Health Research Foundation of Canada, $56,000, December 2009.

Barrett J (Principal Applicant). Maternal Mortality in Canada. A Consensus Meeting. Federal Ministry of Health, $40,000, December 2009.

Barrett J (Principal Investigator); Allen AC, Armson BA, Asztalos EV, Farrell SA, Gafni A, Hannah ME, Hutton EK, Joseph KS, Ohlsson A, Okun NB, Ross SJ, Willan AR (Co- Investigators), Ornstein M (Site Coordinator), Zaltz A (Site Coordinator). The Twin Birth Study: A multicentre randomized controlled trial comparing planned Caesarean section with planned vaginal birth for twins at 32-38 weeks’ gestation. Canadian Institutes of Health Research Grant Award (Randomized Controlled Trials), $8,608,045 total, $956,449 per annum, 2003 – 2011.

41 Belik J, (Principal Investigator) Letarte, M. (Co-Investigator). eNOS uncoupling and role of bone morphogenetic protein-9 in the regulation of pulmonary vascular tone during development and following pulmonary hypertension. Heart & Stroke Foundation. $173,812 total, $86,906 per annum, Operating Grant, 2007 – 2009.

Belsham DD. (Principal Investigator). Sensing of peripheral nutrient status by the hypothalamus. Canadian Institutes of Health Research, Renewal, $790,770, $158,154 per annum, April 2008 – March 2013. Belsham DD (Principal Investigator). Molecular mechanisms dictating control of neuroendocrine function by estrogen. Canadian Institutes of Health Research, Operating Grant, Renewal, $752,940, $150,588 per annum, Renewal, April 2009 – March 2014.

Belsham DD. Canada Research Chair Award in Neuroendocrinology, Tier 2, Renewal, $500,000, $100,000 per annum, July 2009 – June 2014.

Berger H. Implementation and integration of a Unified Electronic Ultrasound Reporting System and Perinatal Health Care Record. Academic Funding Program Innovation Grant, $108,000, Year 1: $64,000 Year 2: $44,000, June 2009 – 2011.

Bernardini M. Clinical and immunohistochemical classification for carcinosarcoma of the uterus. University of Toronto Department of Obstetrics and Gynaecology Research Fund, $10,000, 2009.

Best C, Lovatsis D. Randomized controlled trial of Short-term Uresta Efficacy (SURE trial). Mount Sinai Hospital Research Fund, $7000, 2010.

Bocking AD (Project Co-ordinator), Caloia D, Spitzer RF. Emergency Obstetrical Training (EmOC) in Western Kenya. Developmental Partnerships in Higher Education (DelPHE), British Council, UK, £30,000 per annum, September 1, 2009 – August 31, 2012.

42 Bortolini M, (PI). Shynlova O, Drutz H, Alarab M. Expression of smooth muscle contractile machinery proteins in the vaginal tissue of women with and without pelvic organ prolapse. Physicians’ Services Incorporated Foundation (PSI) Award, $16,400, December 2009 – December 2010.

Bortolini M(PI), Shynlova O, Drutz H, Alarab M. Expression of procollagen c proteinase in the vaginal tissue of women with and without pelvic organ prolapse. Mount Sinai Hospital Research Fund, $8000, March 2010 – February 2011.

Branko B, Lee SK. Initiative for Translational Hypertension Research. University of Alberta, $300,000, 2008 – 2011.

Brown AD (PI), Abramson B, Bierman A, Davis D, Laporte A, Levinton C, Maclean H, Mahomed N, Stewart DE, Wilson C (Co-Applicants). Measuring and understanding gender equity in access to care. Canadian Institutes of Health Research, IGO-81095, $78,021, October 01, 2009 – September 30, 2010.

Brown TJ (PI). Identification and functional analysis of nuclear receptor coactivator 4 isoforms expressed during mouse development. NSERC Discovery Grant, $36,500 per annum, 2005 – 2010.

Brown TJ (PI), Ringuette M, Winegarden N. Androgen modulation of TGFβ signaling in ovarian cancer cells. CIHR Operating Grant, $598,000, 2009 – 2013.

Brown TJ, Rosen BP (Principal Investigators); Colgan TJ, Greenblatt EM, Murphy KJ, Tone AA, Virtanen C (Co-Investigators). Sustained ovulation-associated inflammatory signaling in fallopian tube epithelium as a predisposing factor of serous carcinoma. CIHR Operating Grant, $435,884, 2010 – 2013.

Brown TJ, Sweet J, Kollara A, Winegarden N (Co-PIs). Identification of biomarkers and novel therapeutic targets for testicular germ cell cancers. UHN Foundation Seed Grant, $20,000, 2009.

Brown TJ, Sweet J, Fleshner N, Winegarden N (Co-Is). Stromal factors promoting prostate cancer progression. Prostate Cancer Foundation, $60,000, 2009 – 2010.

Bruneau B (Principal Investigator), Chitayat D. Genetic basis of cardiac development and malformation. Canadian Institutes of Health Research, $496,312, 2005 – 2010.

Cadesky K (PI). AMH as a predictor of ovarian reserve. LifeQuest Center for Reproductive Medicine, General Research Fund, 2009.

Cadesky K (Co-PI). Blood group and incidence of identical twins colab-sperm DNA integrity and birthrate. LifeQuest Center for Reproductive Medicine, General Research Fund, 2009.

Caniggia I (Principal Investigator), Jurisicova A , Post M(Co-Investigators). The role of Bcl-2 family members in regulating placental cell fate. Canadian Institutes of Health Research Operating Grant, $ 757,050 total, $152,134 per annum, 2008 – 2013.

Caniggia I (Principal Investigator), Post M (CI). Monoclonal antibodies against hydroxylated HIF as a diagnostic tool for pregnancy disorders. MaRS MI Proof of Principal, $50,000, 2010.

Caniggia I (Principal Investigator), Post M, Zamudio S (CIs). The role of oxygen in regulating placental development. Canadian Institutes of Health Research Operating Grant, $787,490 total, $156,000 per annum, 2008 – 2013.

Casper RF (Principal Investigator). Brown TJ, Shapiro C. Prevention of circadian rhythm disruption by nocturnal lighting. CIHR, Operating Grant, $107,705.50 per annum, October 2008 – September 2011.

Casper RF (Principal Investigator), Rahman SA, Shapiro CM (Co-Investigators). Ameliorating affective disorder induced by circadian rhythm disruption. CIHR, Operating Grant, $427,126, 2010 – 2013.

Challis JRG, Lye SJ (Co-PIs). Paracrine controls of human labour. Canadian Institutes of Health Research, $792,120; $158,424 per annum; Operating grant, October 2005 – September 2010.

44 Challis JRG (PI), Lye SJ, MacCalman CD, Rurak DW, Gibb W. Regulation of prostaglandin synthesis, metabolism and action in pregnancy and parturition. Canadian Institutes of Health Research, Operating Grant, $792,450; $158,490 per annum, October 1, 2004 – September 30, 2009.

Classens C (PI), Ferguson SE (CI), Urowitz S (CI), Wiljer D (CI). Development of an internet- based support group for sexual problems due to gynaecologic cancer. CCSRI, $35,000 total, $17,500 per annum, May 1, 2008 – April 30, 2010.

Connelly PW, Hanley AJ, Retnakaran RR, Sermer M, Zinman B. Role of the aginine/nitric oxide metabalome in the early history of cardiovascular disease in young women. CIHR, Operating grant, $100,000 per annum, March 1, 2010 – February 28, 2011.

Dennis, C-L E (PI), Fung, K, Gagnon, AJ, Grigoriadis S, Noh S, Stewart DE (CIs). New mothers in a new country: Understanding postpartum depression among recent immigrant and Canadian-born Chinese women, CIHR Operating Grant, $469,691, 3 years 6 months, 2009 – 2013.

Dennis CL (PI); Fung K, Gagnon A, Grigoriadis S, Noh S, Stewart DE (Co-Applicants). Canadian Institutes of Health Research. New mothers in a new country: Understanding postpartum depression among recent immigrant and Canadian-born Chinese women. $557,208, March 2010 – September 2012.

45 Derzko CM (PI), Josse R (Co-Applicant). A double-blind, randomized, placebo-controlled study assessing the safety and efficacy of DVS SR for the treatment of vasomotor symptoms associated with menopause. Wyeth, Protocol 3151A2-3353-NA, $85,918, Total cost per completed subject $6,701, 2008 – ongoing.

Disaia P, Copeland L, Thigpen T, Alvarez R, Aghajanian C, Fracasso P, Birrer M, Hamilton T, Whitney C, Spirtos N, Miller D, Randall M, Waggoner S, Alberts D, Monk B, Koh W, Walker J, Bookman M, Rodgers W, Gershenson D, Covens A, Nolte S, Mannell R, Fleming G, Bell J, Brown C, Wenzel. GOG Operating Grant, NCI, $107,671,648 US, 2010 – 2015.

Du L, Singhal N, McMillan DD, Aziz K, Lee SK. Impact of (ACoRN) acute care of at risk newborn education program in rural China. Canadian Institutes of Health Research, $180,000; 2008 – 2011.

Ellis J, Scherer S, Weksberg R (Co-Applicants). Patient iPS cells with copy number variations to model neuropsychiatric disorders. National Institutes of Health, $207,388, 2009 – 2011.

Feig DS (Principal Investigator); Armson BA, Asztalos EV; Fantus, Ivan G; Lee, SK, Lipscombe L, Murphy KE, Ohlsson A, Ryan EA, Tomlinson GA, Zinman B (Co- Investigators). The MiTY Trial (Metformin in Women with Type 2 Diabetes in Pregnancy). CIHR, Operating Grant, $1,735,119, 2010 – 2015.

Feig DS, Lipscombe LL, Booth GL., Shah BR, Ray JG, Lowe J. Hypertensive disorders of pregnancy and future risk of diabetes in affected women and their offspring. Canadian Diabetes Association Operating Grant, 2010-2012.

Ferguson SE, Catton P. Development of survivorship and education program for gynecologic cancer patients. Princess Margaret Foundation – Weekend to End Women’s Cancer 2009, $120,000 per annum, 2009 – 2010.

Ferguson, SE (PI), Clarke B, Aronson M, Bernardini M, Gallinger S, Oza A, Mackay H, Pollet A (Co-Applicants). Screening for Lynch Syndrome in women with endometrial cancer using predetermined clinicopathologic criteria: A prospective cohort study. Mount Sinai Hospital Obstetrics and Gynaecology Research Fund, $6,000, 2010 – 2011.

46 Ferguson SE(PI), Urowitz S (Co-PI), Classens C (Co-PI). Development and validation of the modified sexual adjustment and body image scale in women with a diagnosis of gynecologic cancer (SABIS-G). Princess Margaret Hospital Foundation, $15,000, 2009 – 2010.

Fombonne E, Evans AC, Mottron L, Scherer S, Volden J, Bryson S, Iarocci G, Roberts W, Smith I, Zwaigenbaum L, Burack J, Mirenda P, Rouleau G, Szatmari P, Weksberg R (Co-Applicant). Autism Research Training (ART) Program. Canadian Institutes of Health Research, $1,950,000, 2009 – 2015.

Fraser W, Weksberg R (Co-PI). Integrated Research Network in Perinatology (IRNPQ) – Impact of intrauterine exposures on infant health and development. Canadian Institutes of Health Research/Canadian Foundation for Innovation, $20,000,000 total, $100,000 per annum for Weksberg lab, 2008 – 2013.

Friedman JM (Principal Investigator), Chitayat D. Canadian Molecular Cytogenetics Platform. Canadian Foundation for Innovation, $4,512,925, 2005 – 2010.

Friedman JM (Principal Investigator), Chitayat D. Identifying human mutations that cause mental retardation. Canadian Institutes of Health Research, $2,498,538, 2005 – 2010.

Gagnon AJ (PI) Co-Applicants: Carnevale F, Dennis C, Rousseau H, Stewart DE, Wahoush O. Developing population interventions for migrant perinatal health equity. Canadian Institutes of Health Research, $78, 900, December 2009 – December 2010.

Gien L, Barbera L, Fyles A, Covens A, Khalifa M, Thomas G, Elit L, Rakovitch E, Sutradhar R. Vulvar cancer: Patterns of care. CCSRI, $353,000, 2010 – 2013.

Grace SL, Stewart DE (PIs); Alter DA, Anand SS, Bunkers S, Gupta M, Harvey PJ, Holder G, Kaur R, Oh P, Rukholm EE, Rush JW, Scholey PE, Williamson KM. (Co-Applicants). Cardiovascular secondary prevention for vulnerable populations: An interdisciplinary approach to improving access to services and outcomes (Cardiac Rehabilitation care Continuity through Automatic Referral Evaluation (CRCARE). Canadian Institutes of Health Research, $455, 037, April 2006 – March 2011.

Grace S.L (PI), Suskin N, Arthur HM, Prior P, Reid R, Stewart DE (Co-Applicants). Comparing paper versus electronic transmission of cardiac rehabilitation summaries to primary care physicians: A multi-site multi-method study of information flow and content (the CR2DoC study). Canadian Institutes of Health Research, MOP-74431, $324,697, April 2008 – March 2011.

47 Greenblatt EM (PI). Prevalence of celiac disease in a Canadian population of women with unexplained infertility. Canadian Celiac Association, J A. Campbell Research Award, $25,000, 2009 – 2010.

Greene S, Loutfy M, Carvalhal A, Bitnun A, Brophy J, Kapiriri L, Margolese S, Masinde K, Murphy K, Raboud J, Salter R, Samson L, Smaill F, Yudin M. The psychosocial experiences and needs of HIV-positive women during their first year of motherhood. The Ontario HIV Treatment Network, $450,000, 2010 – 2011.

Gupta A (PI), Lee-Chong A, Allen L, Kives S, Traubici J (Co-Investigators). A pilot prospective study of measurement of ovarian function in adolescent females receiving cancer therapy. Comprehensive Cancer Center, $50,000, July 1, 2009 – July, 2010 with extension to 2011.

Harris D (PI), Rogers IM (CI). A model for analyzing the role of extrinsic factors responsible for aging of the human immune system. NIH Eureka Grant, $960,000, $240,000 per annum, 2010 – 2014.

Hellmann J, Shah P, Lee SK. Death in Canadian Neonatal Intensive Care Units (NICUs): Exploring the ethical determinants. Canadian Institutes of Health Research, $99,698; 2008 – 2010.

Hodgson D (Principal Investigator), Greenblatt EM, Catton P, Sridhar S, Azad A (Co- Investigators), McArdle O. Fertility in young breast cancer survivors – a novel assessment of ovarian reserve. Canadian Breast Cancer Foundation, $330,391, March 2008 – March 2011.

Hodnett ED, Stremler RL (PIs), Halpern SH, Willan AR, Windrim R (CIs). Labour Position Trial 2. CIHR, Operating Grant Priority Announcement, $100,000, March 2010 – February 28, 2011.

Holtzman S (PI); Barata P, Stewart DE. Understanding and measuring the construct of irritability in men and women. Canadian Institutes of Health Research, $98,940, March 1, 2010 – February 28, 2011.

48 Ickowicz A, Weksberg R (Co-PI), Butcher D. Identifying epigenetic targets of lithium: An in- vitro pilot study. Psychiatric Endowment Fund, $23,375, 2009 – 2010.

Janssen P, Lee SK. Antepartum Care of High Risk Pregnancy Team. Canadian Institutes of Health Research, $213,000, 2008 – 2011.

Jenkins D, Gaisano H. (Primary Applicants), Belsham DD (Co-Applicant). Diet, the Digestive tract and Disease: The 3D Centre. Canadian Foundation for Innovation, New Initiatives Fund 2009, $5,437,276, June 16, 2009.

Jones JM, Howell DM (Principal Investigators); Buchman SH, Catton P, Earle CC, Ferguson S, Fitzgerald BJ, Gagliardi AR, Gospodarowicz M, Harrison MB, Jadad AR; Jusko Friedman A, Sharpe MB, Urowitz S, Warde PR, Wiljer DE (Co-Investigators). Transition to Survivorship: Translating knowledge into action for testicular and endometrial cancer populations. CIHR, Operating Grant, $311,007 total; $103,669 per annum, 2010 – 2013.

Josse R (Principal Investigator), Derzko CM, Rubin L (Co-Investigators). A randomized open- label study to evaluate the safety and efficacy of denosumab and monthly actonel therapies in postmenopausal women transitioned from weekly or daily alendronate therapy. Amgen Protocol 20080099. $5,456 per patient, 2009-ongoing.

Jurisica I, Oza AM (Principal Investigators), Colgan TJ, Jurisicova A, Kislinger T (Co- Applicants). Diagnostic and prognostic biomarkers for epithelial ovarian cancer. Canadian Institutes of Health Research, Operating Grant, $161,125 per annum, 2009 – 2013.

Jurisicova A. Canada Research Chair. CIHR, $175,000, July 1, 2008 – June 30, 2013.

Jurisicova A. Mouse models of ovarian cancer. Grant Miller Research Foundation, $20,000, 2008 – 2012.

Jurisicova A (PI) Molecular pathways of oocyte aging. CIHR, Catalyst Grant: Pilot Projects in Aging, $50,000, January 1, 2009 – December 31, 2009.

Keunen J, Woleve T, Southgate K. The effect of a low glycemic index diet on blood sugar control in pregnancy women at risk for gestational diabetes. September 2009 – September 2011.

Kim Y-IJ, O'Connor DL (Principal Investigators); Berger H, Lausman AY (Co-Investigators). Effects of prenatal folate exposure on DNA methylation in the newborn infants. CIHR, Operating Grant, $448,683, 2010 – 2013.

Kingdom J (PI) “HEPRIN” trial. Physicians’ Services Inc., $122,000, September 2007 – August 2010.

Kingdom J, Bainbridge S. Low levels of activity of the gene, Gem 1, are observed in the placentas of women with poor pregnancy outcomes – is this a correlate or a cause? MSH Research Foundation, Department of Obstetrics and Gynaecology, $7,500, July 2009 – June 2010.

Kingdom JCP (PI), Keating S, Cross J, Dunk C (Co-Applicants).Villous trophoblast turnover. Canadian Institutes of Health Research Award, $538,888 total, 2006 – 2010.

Kingdom J, Librach C (Co-Applicants). A prospective study on the prediction of preeclampsia using an HLA-G gene mutation. Canadian Institutes of Health Research, $148,221, September 2008 – August 2011.

Kives S. Randomized controlled trial of continous oral contraceptives vs. cyclical oral contraceptives in adolescents. Physicians’ Services Inc. Foundation, $75,000, 2005 – present.

50 Lambe EK (PI). Signal transduction and adult cortical network activity. National Science and Engineering Research Council (NSERC) Discovery Grant (Operating), $178,125 total ; $35,625 per annum, 2007 – 2012.

Lee SK. Maternal Infant Care (MICare) Research. Ontario Ministry of Health & Long Term Care, $15,000,000, 2009 – 2013.

Lee SK (PI), Armson BT, Khalid A, Baker GR, Barrington KJ, Dendukuri N, El-Hajj MO, Hayward RSA, Joseph KS, Liston RM, Magee LA, O'Campo P, Ohlsson A, Saigal S, Sauve RS, Shaw NT, Skarsgard ED, Stevens BJ (Co-Investigators). CIHR Team in Maternal Infant Care, $1,727,068, October 1, 2008 – September 30, 2013.

51 Letarte M (Principal Investigator). Proteins differentially expressed in ovarian epithelium of BRCA1 carriers as potential biomarkers for ovarian cancer. Ovarian Cancer Canada, $30,000, Operating Grant, 2008 – 2009.

Letarte, M. (P.I.) Soluble endoglin in endothelial cell function and hypertension associated with preeclampsia. Heart and Stroke Foundation of Canada, Operating grant, $344,273; $114,758 per annum, 2010 – 2013.

Levitan RD (Principal Investigator), Davis C, Kennedy JL, Loucks EB, Matthews SG, Meaney MJ, Soares CD, Steiner MA (Co-Investigators). Longitudinal study of food reward and obesity in young children: The role of gene-environment interaction. Canadian Institutes of Health Research, Operating Grant, $156,078 per annum, $780,390, 2009 – 2014.

Leyland N (PI). FAST Trial multicentre trial of intrauterine ultrasound-guided radio-frequency ablation of myomata. GYNESONICS, $2,500,000, 2009 – 2011.

Librach CL, Kingdom JC (PIs). Prediction of preeclampsia using an HLA-G gene single nucleotide polymorphism (SNP). Canadian Institutes of Health Research, Operating Grant, $266,337, 2008 – 2011.

Lothar L, Derzko C (Co-Investigators) Use of Optical Breast Spectroscopy (OBS) for evaluation and comparison of short-term breast tissue changes occurring in post-menopausal women initiating various (menopausal) hormonal therapies. Weekend Walkers Breast Cancer Innovation Fund, $84,000, 2010.

Lye SJ (Principal Investigator). Myometrial programming: A new concept underlying the control of myometrial contractility during pregnancy. Canadian Institutes of Health Research, Operating grant, $727,080 total, $145,416 per annum, October 1, 2005 – September 30, 2010.

Lye SJ. Fetal, neonatal and maternal health. CIHR, Tier 1 Canada Research Chairs Program, Operating grant, $1,400,000; $200,000 per annum, July 1, 2008 – June 30, 2015.

Lye SJ (PI), Adams L, Beilin L, Briollais L, Matthews S, Newnham J, Olynyk J, Palmer L, Pennell C. Gene environment interactions underlying DOHaD. Canadian Institutes of Health Research, Operating grant, $876,529, $175,306 per annum, April 1, 2010 – March 31, 2015.

52 Lye SJ (PI), Adamson SL, Challis JRG, Danska J, Matthews S, Osborne L, Pennell C, Rossant J (CIs). A murine model to investigate the mechanisms underlying DOHaD. Canadian Institutes of Health Research, Operating grant, $373,673, $124,558 per annum, October 1, 2006 – September 30, 2009.

Lye, SJ (PI), Adamson L, Matthews SG. Pennell CE (Co-Investigators). A murine model to investigate the mechanisms underlying DOHaD. CIHR, Operating Grant, $910,852, ($182,170 per annum), 2009 – 2014.

Lye SJ (PI), Beilin L, Briollais L, Challis J, Doherty D, Matthews S, Newnham J, Ozcelik H, Palmer L, Pennell C, Siminovitch K, Stanley F, van Eekelen J, Zubrick S. Gene environment interactions underlying the developmental origins of health and disease. Canadian Institutes of Health Research, Operating grant, $408,828 total, $136,276 per annum, April 1, 2007 – March 31, 2010.

Lye SJ (Principal Investigator), Dunk C, Keating S, Maxwell C. Extra villous trophoblast mediated utero-placental vascular remodelling. Canadian Institutes of Health Research, Operating grant, $713,265; $142,653 per annum, April 1, 2007 – March 31, 2012. Lye SJ (PI), Pennell C, Shynlova. Peripheral leukocytes as targets for preterm birth prevention. March of Dimes Birth Defects Foundation, Operating grant, $482,300 U.S, $160,767 U.S. per annum, March 1, 2010 – February 28, 2013.

Lye SJ (Principal Investigator); Shynlova O (Co-Investigator). Control of myometrial contractile activity during pregnancy. CIHR, Operating Grant, $912,320, 2010 – 2015.

MacMillan HI, Stewart DE, Coben J, Herrman HE, Wathen CN (PI’s); Afifi TO, Ahmad F, Barata PC, Barlow N, Boyle MH, Chamberland C, Chartier MJ, Collin-Vezina D, Diaz-Granadas N, Donelle LF, Dudding P, Edleson JL, Erickson PG, Feder G, Ford-Gilboe MV, Gagnon AJ, Georgiades KK, Gonzales A, Hegadoren KM, Hegarty KL, Jack SM, Jackson BE, Jenkins R, Kelleher KJ, Kothari AR, Olds DL, Oliffe JL, Sareen J, Schmidt LA, Sibbald SL, Thombs BD, Tonmyn LE, Trocme N, Varcoe CM, Waddell CA, Wekerle CM (Co-Applicants). Violence across the lifespan. Canadian Institutes of Health Research, Centre for Research Development in Gender, Mental Health, $2,000,000, September 2009 – September 2013.

Matthews SG (PI). Multidrug resistance in pregnancy. Canadian Institutes of Health Research, Operating Grant, $637,980 total, $127,596 per annum, 2005 – 2010.

Matthews SG (PI). Maternal stress in pregnancy programs endocrine function and behaviour in adult offspring. Operating Grant, Natural Sciences and Engineering Research Council of Canada (NSERC), $237,500 total, $47,500 per annum, 2006 – 2011.

53 Matthews SG (PI). Multidrug resistance in the developing brain barrier: Fetal brain protection. Canadian Institutes of Health Research, Operating Grant, $449,548 total, $112,387 per annum, 2007 – 2011.

Matthews SG (PI). Trangenerational effects of antenatal glucocortocoid treatment: Mechanisms of programming. CIHR, Operating Grant, $479,331, $159,777 per annum, October 1, 2009 – September 30, 2012.

McCulloch C(PI) , Brown TJ, Ringuette M. Bone sialoproteins in skeletal metastasis. CIHR, Operating Grant, $430,822, 2008 – 2011.

McKenzie K (PI), Noh, S., et al., Stewart DE. (Co-Applicants). Strategic training program for the social etiology of mental illness. Canadian Institutes of Health Research, $1,790,000, 2009 – 2015.

Meffe F (PI), Biringer A, Seaberg R, Espin S, Simmonds A, Sharpe M, Van Wagner V, Caccia N, Lee S (Collaborator). Strategic directions in interprofessional education and interprofessional collaboration in maternity care. Funded by the Ministry of Health and Long Term Care, HealthForceOntario, Interprofessional Care Fund, $315, 563, April 2009 – September 2010.

Miranda V, Lovatsis D. Randomized controlled trial of cystocele plication risks (CPR Trial). MSH Research Fund, $6,150, April 2009 – March 2010.

54 Munjanja SP, Thistle P, Magwali T, Manase M, Madziyire G, Zvandasara P, Magure T, Marume A, Chipato T, Mushangwe V, Kasule J, Rusakaniko S, Kawanzaruwa W, Malunga G. Maternal and perinatal mortality prevention of mother to child transmission. Department for International Development (United Kingdom), $640,117 US, 2007 – 2017.

Nagy A (PI), Rogers IM, Rossant J, Wrana J, Zandstra P, Woodgett J(Co-PIs). Characterization of cell reprogramming mechanisms. Ontario Ministry of Research and Innovation Global Leadership Round in Genomics & Life Sciences (GL2), $9,058,220, $2,264,555 per annum, 2010 – 2014.

Narod SA (PI), Ghadirian P, Malkin DD (CIs). Genetic susceptibility to esophageal cancer. Canadian Institutes of Health Research, Operating Grant, $552,132, 2008 – 2011.

Narod S. BRCA1, BRCA2 and ovarian cancer survivorship. Canadian Cancer Society Research Grant. 2009/2010: $131,648; 2010/2011: $86,394, 2009 – 2011. Narod SA (Principal Investigator), Bristow RG, Nam RK, Trachtenberg J (Co-Investigators). Clinical Course of BRCA2-associated prostate cancer. CIHR Operating Grant, $425,989, 3 years, 2009 – 2012.

Narod S. Risk factor analysis of hereditary breast and ovarian cancer. Canadian Breast Cancer Research Alliance Operating Grant. $297,900 per annum, $1,489,500 total, 2009 – 2014.

Nevo O.The role of sFlt-1 heterodimers in the pathogenesis of preeclampsia. Dean's Fund New Staff Grants, University of Toronto, $10,000, 2009.

Nulman I (PI), Koren G, Barrera M, Warner E, Maxwell C, Sermer M, Tozer R, Madarnas Y, Brezden-Masley C, Sridhar S, Colapinto N (CIs). Neurodevelopment of children exposed in utero to chemotherapy for maternal breast cancer. Canadian Breast Cancer Foundation. $145, 419 per annum, 2010 – 2013.

Olson D (Principal Investigator), Bocking AD. Preterm birth and healthy outcomes. Alberta Heritage Foundation for Medical Research (AHFMR), $1,000,000 per annum, 2008 – 2012.

55 Olson D, Lee SK. Preterm birth and healthy outcomes. AHFMR, $5,000,000, 2008 – 2013.

Ray JG. InterPreg Study. Canadian Institutes of Health Research. Operating Grant, $47,000 per annum, 2005 – 2010.

Ray JG. New Investigator Award. Canadian Institutes of Health Research. $250,000, 2005- 2010.

Retnakaran Ravi R, Connelly Philip W, Floras John S, Hanley Anthony J, Roberts SW, Loh A, Feigenbaum A, Weiss S, Marcon C, Goldfarb C, Berall G, Bradley E, Brian J, Freeman N, Atkinson A, Taylor M, Stinson J, Mitchell S, Green P, Chitayat D. Autism speaks. Autism Treatment Network: Cooperative Multi-Center Program for Research and Treatment of Autism, $408,000, 2008 – 2010.

Rogers IM (PI). Differentiation of blood cells into insulin producing cells for the treatment of type 1 diabetes. MaRS Innovations, $65,000, 2009 – 2010. Rogers I (PI). Stem cell therapy for type 1 Diabetes. MaRS Innovations, $68,000, 2009 – 2010.

Rogers IM (PI). Treatment of peripheral vascular disease with stem cells. Stem Cell Network Impact Grant, $75,000, 2009 – 2010.

Rogers IM (PI). Comparison of CD34+ cells versus CD34+ cultured cells in the treatment of PVD. MaRS – Proof of Principle. $50,000, 2010 – 2011.

Rogers IM (PI). Treatment of type 1 diabetes with stem cells. CIHR – Proof of Principle, $150,000, 2010 – 2011.

56 Rosen B. Canadian synoptic reporting in Canada. Canadian Partners against Cancer, $243,000 per annum, 2008 – 2010.

Rossant J. Lineage development in the mouse blastocyst. CIHR, Operating Grant, $1,012,210, 2009 – 2014.

Rossant J (Principal Investigator). Transcriptional networks in trophoblast stem cell development. CIHR, Operating Grant, $1,049,389, 2010 – 2015.

Sellers T (PI), Narod S (Co-Applicant). Haplotype-based genome screen for ovarian cancer loci. NIH/NCI, Grant #: R01 CA114343-01 A2, $50,000 US, March 2007 – February 2010.

Serghides L (PI), Loutfy MR, Murphy KE, Yudin MH. Angiogenesis and adverse pregnancy outcomes in women with HIV, a pilot study. CIHR, $95,710, March 1, 2010 – February 28 2011.

Sermer M (Collaborator). Thrombophilia in Pregnancy Prophylaxis Study. Heart and Stroke Foundation of Canada, $24,000 per annum, 2006 – 2011.

Sermer M (CI). The Canadian Healthy Infant Longitudinal Development (CHILD) Study. CIHR, $347,549 per annum, 2007 – 2016.

Sermer M (PI). Food Frequency Questionnaire Validation Study – MIREC. Toronto Health Canada, $9,999 per annum, 2009 – 2011.

Sermer M (Site Coordinator). Evaluation of natural killer cell contributions to the known elevated risks for maternal and fetal pathologies in diabetic pregnancy. CIHR, $9,000 per annum, 2010 – 2011.

57 Sermer M (PI) MIREC Infant Development Study (MIREC FFQ), $35,000 per annum, 2010 – 2011.

Sermer M (CI). Investigation of the prognostic importance of natiuretic peptides in pregnant women with heart disease: A prospective observational cohort study. HSFO, $69,970 per annum, 2010 – 2012.

Sierra S (Principal Investigator). Microarray analysis of the endometrium in women with recurrent early pregnancy loss and in women with recurrent implantation failure. Physicians’ Services Incorporated Foundation, $36,500, 2007 – 2010.

Silverman M, Thistle P. Effectiveness of Nelfinavir-based Haart in prevention of infant adverse events in a rural setting In Zimbabwe. The Rotary Foundation, $47,000 US, 2008 – 2010.

Siu KWM (PI). Colgan TJ. Translating head and neck cancer markers into diagnostic assays. York University, International Science and Technology Partnerships Canada (ISTPCanada), ISTP Program with India. $1,163,312; $290,828 per annum, 2009 – 2012.

Sloan E (PI) Driver H, Maxwell C, Ryan C, Finan E (CIs). Obstructive sleep apnea during pregnancy in obese women: Impact on fetal development. Ontario Ministry of Health Mount Sinai Hospital/University Health Network Academic Medical Organization Innovation Fund (IF), $108,850, 2009 – 2011.

Spitzer RF. Development of a partograph algorithm for use on PDAs in a global context. $4,000 & Evaluation of the ALARM International Program in Kenya. $1,000; Mount Sinai Department of Obsterics and Gynaecology Research Fund, $5000 total, July 2009 – June 2010.

Stevens B, Lee SK. CIHR Team in Children’s Pain. Canadian Institutes of Health Research. $4.7 million, 2006 – 2011.

Thistle P. Colab cervical cancer prevention and screening: Visual inspection of the cervix with acetic acid. Long term methods of family planning. Rotary Club of Toronto Eglinton Foundation, $30,000, 2010.

Thombs B (PI), Stewart DE (CI). A systematic review of screening for psychosocial factors in breast cancer. Canadian Breast Cancer Research Alliance, $200,000, June 2009 – June 2010.

Tremblay L, Bakirtzian A, Benhabib B, Ternamian A (Principal Investigators), Tyrwhitt J. Interdisciplinary collaborative robotic automated port application research. Department of Kinesiology, the Division of Gynecologic Endoscopy, Department of Obstetrics and Gynecology and the Department of Research and Knowledge Management at St. Joseph's Health Centre, Department of Clinical Biomedical Engineering, University of Toronto, $5000 and in kind donations, 2007 – 2010. von Dadelszen P (PI), Nsermino JM, Douglas MJ, Gruslin AMR, Lee SK, MacNab YC, Magee LA, Moutquin JM, Ouellet A, Russell JA, , Graeme N, Walley KR. PIERS (pre-eclampsia integrated estimate of risk for mothers): Validation across conditions and clinical settings. CIHR, Operating Grant, $705, 649, July 1, 2007 – June 30, 2010.

59 Weksberg R (PI). Organization for the Study of Sex-Differences, Third Annual Meeting. Canadian Institute of Health Research, $15,000, 2009.

Weksberg R (PI). Constitutional epigenetic and genetic errors and the risk of paediatric cancer. HSC Foundation New Ideas Grant. $50,000, 2009 – 2010.

Weksberg R, Chitayat D, Kingdom J, Keating S. Investigation of intrauterine growth restriction by gene expression and DNA methylation profiling. Heart and Stroke Foundation, CIHR, $383,883, April 2007 – March 2011.

Weksberg R (PI), Keating S, Kingdom J, Chitayat D. Epigenetic programming and genome function during development – IUGR as a model system. CIHR, $127,961 per annum, 2008 – 2011.

Weksberg R (PI), Kingdom J, Chitayat D, Keating S. Investigation of intrauterine growth restriction by gene expression and DNA methylation profiling. Canadian Institutes of Health Research, $405,386, 2008 – 2011.

Weksberg R (PI), Roberts W, Scherer S. Genome-wide DNA methylation profiling in Autism. Canadian Institute of Health Research, $593,815, 2008-2011.

Wen, Shi Wu (Principal Investigator), Coyle DA, Davidge ST, Fergusson DA, Fraser WD, Kingdom JC, Lee, SK, Perkins SL, Smith GN, Walker MC, Wells GA (Co-Investigators). Effect of folic acid supplementation in pregnancy on preeclampsia. CIHR Randomized Controlled Trials Program, $705,290, October 1, 2009 – September 30, 2014.

Wolever TMS, O'Connor D, Josse RG, Feig DS, Ray JG, El-Sohemy A. The effect of a low glycemic index (GI) diet on maternal and neonatal markers of glycemic control and post-partum diabetes risk. Canadian Diabetes Association, 2010 – 2013.

Yudin M (Collaborator). Mechanism of aging following exposure to HIV antiretroviral drugs. Canadian Institutes of Health Research (CIHR), $485,586, Emerging Team Grant, 2007 – 2012.

Yudin M (CI). National HIV Pregnancy Planning Guidelines Development Team meeting. Canadian Institutes of Health Research (CIHR), Institute of Infection and Immunity, Emerging Team Grant, $16,146, 2009 – 2010.

60 Yudin M (CI). Ontario HIV Pregnancy Planning Initiative: A provincial evidence-based multidisciplinary program assisting people living with HIV with fertility and pregnancy planning. Women’s College Hospital AFP Innovation Funds, $30,000, 2009 – 2010.

Yudin M (CI). Angiogenesis and adverse pregnancy outcomes in women with HIV, a pilot study. Canadian Institutes of Health Research (CIHR), Institute of Infection and Immunity, Catalyst Grant, $95,710, 2010 – 2011.

Yudin M (CI). The psychosocial experiences and needs of HIV-positive women during their first year of motherhood. Ontario HIV Treatment Network (OHTN), Research Operating Grant, $450,000, 2010 – 2013.

Zinman B, Retnakaran RR, Hanley AJG, Sermer M, Connelly PW. Role of the arginine/nitric oxide metabolome in the early natural history of cardiovascular disease in young women with varying degrees of glucose intolerance in pregnancy. Canadian Diabetes Association, 2010 – 2013.

61 2010-2011

RESEARCH GRANTS AND INVESTIGATIONS

PI=Principal Investigator; CI=Co-Investigator

Adamson SL (PI). Cardiovascular phenotyping in embryonic and newborn mice. CIHR, Equipment and Maintenance Program, $122,109 ($81,984 per annum Equipment + $8,025 per annum Operating), October 2005 – September 2010.

Alarab M (PI). Expression of modulators of collagen and elastin remodeling in vaginal tissue of premenopausal women with severe pelvic organ prolapse, Physicians’ Services Incorporated Foundation, $ 28,600, December 2009 – December 2010.

Amsalem H, Kingdom J. Decidual neutrophils a novel finding: Their role in second trimester placentation. Physicians’ Services Incorporated, Resident Research Grant. $ 15,000, 2009-2010.

Azar R (PI), Bélanger M, Kelly Spurles, PL, Letourneau NL, Sermer M. Maternal prenatal negative mood & infant stress and immunity: Could increased inflammation during pregnancy be the linking mechanism? Operating grant. $88,888, March 1, 2011 – February 29, 2012.

Bainbridge SA(PI), Adamson SL, Kingdom JC (Supervisors). Effect of reduced placental expression of Glial Cell Missing-1 (Gcm1) on pregnancy. CIHR, CIHR Fellowships, September 2009 – December 2010.

Balki M (PI), Carvalho JCA, Wax R, Windrim R (CIs). Assessment of critical skills of practising anesthesiologists with high-fidelity obstetric anaesthesia simulation. MSH UHN AMO Phase III Innovation Funds, $75,958, 2009 – 2010.

Baillargeon J-P, Auger J, Belisle S, Waddell G (PIs); Carranza-Mamane B, Hivert M-F, Langlois M-F, Lavoie HB, Pesant M-H, Poder TG (CIs). Greenblatt E (Collaborator). Evaluation of clinical outcomes and costs of a transferable interdisciplinary lifestyle intervention pre-and per- pregnancy in obese infertile women. CIHR and Quebec Ministry of Health, Partnerships for Health System Improvement, FRN-114125, $345,500, April 2011 – March 2014.

Barbera L, Chivers M, Ferguson SE, Urowitz S, Wiljer D (CIs). Development of Internet- Based support group for sexual problems due to gynecologic cancer. National Cancer Institute of Canada (NCIC), $35,000, 2008 – 2010.

63 Barrett J (Principal Investigator); Allen AC, Armson BA, Asztalos EV, Farrell SA, Gafni A, Hannah ME, Hutton EK, Joseph KS, Ohlsson A, Okun NB, Ross SJ, Willan AR (Co- Investigators), Ornstein M (Site Coordinator), Zaltz A (Site Coordinator). The Twin Birth Study: A multicentre randomized controlled trial comparing planned Caesarean section with planned vaginal birth for twins at 32-38 weeks’ gestation. Canadian Institutes of Health Research Grant Award (Randomized Controlled Trials), $8,608,045 total, $956,449 per annum, 2003 – 2011.

Belsham DD. Canada Research Chair Award in Neuroendocrinology, Tier 2, Renewal, $500,000, $100,000 per annum, July 2009 – June 2014.

Bernardini M (PI), Gien L, Ferguson S, Murphy J, Rosen B (CIs) A prospective study evaluating surgical and quality of life outcomes after robotic surgery, laparoscopy, and laparotomy in the management of uterine and cervix cancer. AFP Innovation Fund, 2010-2011: $91,910; 2011-2012: $92,699, $188,009 total, 2010 – 2012.

Bernardini M (PI). Intra-operative lymph node evaluation using a handheld PET Gamma Probe in endometrial cancer surgery – A pilot study. MSH OBGYN Division Funding, $5000, July 2011 – June 2010.

Best C, Lovatsis D. Randomized controlled trial of Short-term Uresta Efficacy (SURE trial). Mount Sinai Hospital Research Fund, $7000, 2010.

64 Bocking AD (Project Co-ordinator), Caloia D, Spitzer RF. Emergency Obstetrical Training (EmOC) in Western Kenya. Developmental Partnerships in Higher Education (DelPHE), British Council, UK, £30,000 per annum, September 1, 2009 – August 31, 2012.

Bortolini M, (PI). Shynlova O, Drutz H, Alarab M. Expression of smooth muscle contractile machinery proteins in the vaginal tissue of women with and without pelvic organ prolapse. Physicians’ Services Incorporated Foundation (PSI) Award, $16,400, December 2009 – December 2010.

Branko B, Lee SK. Initiative for Translational Hypertension Research. University of Alberta, $300,000, 2008 – 2011.

Brown TJ (PI). Novel functions of nuclear receptor coactivator 4 at the mitotic apparatus. Natural Sciences and Engineering Research Council of Canada (NSERC). $50,000, April 2011 – March 2016.

Brown TJ (PI). Identification and functional analysis of nuclear receptor coactivator 4 isoforms expressed during mouse development. NSERC Discovery Grant, $182,500, 2005 – 2010.

Brown TJ (PI), Ringuette M, Winegarden N. Androgen modulation of TGFβ signaling in ovarian cancer cells. CIHR Operating Grant, $598,000, 2009 – 2013.

Brown TJ, Rosen BP (Principal Investigators); Colgan TJ, Greenblatt EM, Murphy KJ, Tone AA, Virtanen C (Co-Investigators); Allen L, Shapiro J, Farrugia M, Levinsky E (Collaborators). Sustained ovulation-associated inflammatory signaling in fallopian tube epithelium as a predisposing factor of serous carcinoma. CIHR Operating Grant, $435,884, October 2010 –September 2013.

Brown TJ, Sweet J, Fleshner N, Winegarden N (Co-Is). Stromal factors promoting prostate cancer progression. Prostate Cancer Foundation, $60,000, 2009 – 2010.

65 Caccia N. Strategic directions in interprofessional education and interprofessional collaboration in maternity care. HealthForceOntario 2008-2009, Interprofessional Care/Education Fund, $315,563, April 1, 2009 – December 31, 2010.

Caloia D (Co-PI). Electronic medical records to improve patient care & public health in rural Kenya. Centers for Disease Control and Prevention, 1 R18 HK000058-01, $1,347,577 US, October 1, 2007 – September 30, 2010.

Caniggia I (PI). Towards understanding the pathogenesis of preeclampsia. Canadian Institutes of Health Research Ontario Women's Health Council/The Institute of Gender and Health (IGH) Mid-Career Award, $80,000 per annum, 2005 – 2010.

Caniggia I (PI), Jurisicova A , Post M(Co-Investigators). The role of Bcl-2 family members in regulating placental cell fate. Canadian Institutes of Health Research Operating Grant, $ 757,050 total, $152,134 per annum, 2008 – 2013.

Caniggia I (PI), Post M (CI). Monoclonal antibodies against hydroxylated HIF as a diagnostic tool for pregnancy disorders. MaRS MI Proof of Principal, $50,000, 2009 – 2011.

Caniggia I (PI), Post M, Zamudio S (CIs). The role of oxygen in regulating placental development. Canadian Institutes of Health Research Operating Grant, $787,490 total, $156,000 per annum, 2008 – 2013.

Caniggia I (PI), Bhattacharjee J. The role of Mcl-1 in regulating placental cell fate. CIHR HOPE-Scholarship, Operating Grant, $112,000, 2011 – 2015.

Casper RF (PI). Brown TJ, Shapiro C. Prevention of circadian rhythm disruption by nocturnal lighting. CIHR, Operating Grant, $427,126 total, $142,375 per annum October 1. 2008 – September 30, 2011.

Casper RF (PI), Rahman SA, Shapiro CM (Co-Investigators). Ameliorating affective disorder induced by circadian rhythm disruption. CIHR, Operating Grant, $430,821 total, $143,607 per annum, October 2010 – September 2013.

Casper RF (PI), Wolfman W (CI). Aromatase inhibitors added to low dose hormone replacement therapy to reduce mammographic breast density in postmenopausal women. Canadian Breast Cancer Foundation, $450,000 total, $147,763 per annum, September 2009 – August 2012.

Challis JRG, Lye SJ (Co-PIs). Paracrine controls of human labour. Canadian Institutes of Health Research, $792,120; $158,424 per annum; Operating grant, October 2005 – September 2010.

66 Compeau C, Chawla A, Tyrwhitt J, Ternamian A, Kroft J, Ambica A. National multidisciplinary collaborative survey on laparoscopic entry.SOGC, CUA, CAGS, Supported by the Division of Gynecologic Endoscopy and the Department of Research and Knowledge Management at St. Joseph's Health Centre, Toronto, $2,500, 2007 – 2010.

Connelly PW, Hanley AJ, Raboud JM, Retnakaran RR, Sermer M, Zinman B (PIs). Longitudinal associations of adipocytokines and markers of sub-clinical inflammation with changes in insulin resistance and beta-cell function in women with a history of gestational diabetes mellitus. Canadian Institutes of Health Research, $713, 655, July 1, 2007 – June 30, 2012.

Covens A, Carter J, Ali S (PIs). Non radical surgical therapy for Stage IA1-IB1 (≤ 2cm) cervical cancer. Division of Cancer Prevention, National Cancer Institute, 2011 – 2014.

Croy AB(PI), Adams MA, Smith GN (CIs), Sermer M (Site Coordinator). Evaluation of natural killer cell contributions to the known, elevated risks for maternal and fetal pathologies in diabetic pregnancy. 9,000 CAD, 2010 – 2011.

Czikk M (PI), Kingdom J (Supervisor). Dual specificity phophatase 9 (DUSP-9): A candidate gene to explain the male bias in severe placental insufficiency syndrome. Mount Sinai Hospital, Research Foundation, Department of Obstetrics & Gynaecology, $10,000, July 2010 – June 2011.

67 Dennis CL (PI); Fung K, Gagnon A, Grigoriadis S, Noh S, Stewart DE (Co-Applicants). Canadian Institutes of Health Research. New mothers in a new country: Understanding postpartum depression among recent immigrant and Canadian-born Chinese women. $557,208, March 2010 – September 2012.

Diamandis E (PI), Bernardini MQ. An integrated systems biology approach for ovarian cancer biomarker discovery. NIH Sub-Award # 1U01CA152755-01, $42,000, September 2010 to August 2011.

Disaia P, Copeland L, Thigpen T, Alvarez R, Aghajanian C, Fracasso P, Birrer M, Hamilton T, Whitney C, Spirtos N, Miller D, Randall M, Waggoner S, Alberts D, Monk B, Koh W, Walker J, Bookman M, Rodgers W, Gershenson D, Covens A, Nolte S, Mannell R, Fleming G, Bell J, Brown C, Wenzel. NCI, GOG Operating Grant, $107,671,648 US, 2010 – 2015.

Drews SJ, McGeer AJ (PIs), Allen VM, Bujold E, Coleman BL, Johnstone J. Lee BE, Levy M, Loeb MB, Louie M, Manos SH, McNeil SA, Money DM, Murphy KE, Taylor G, Zahariadis G. Outcomes of Pandemic Influenza in Pregnancy (OPIP). $395,825, October 1, 2009 – September 30, 2010.

Du L, Singhal N, McMillan DD, Aziz K, Lee SK. Impact of (ACoRN) acute care of at risk newborn education program in rural China. Canadian Institutes of Health Research, $180,000, 2008 – 2011.

Dupre J (Principal Investigator), Dosch H-M, Lawson ML, Orbine E, Fraser WD, Sermer M (Principal Investigator, Canada). Trial to reduce Insulin Dependent Diabetes Mellitus (IDDM) in the genetically at risk (TRIGR). National Institutes of Health, Canadian Institutes of Health Research, $4,260,000, 2002 – 2012.

Ellis J, Scherer S, Weksberg R (Co-Applicants). Patient iPS cells with copy number variations to model neuropsychiatric disorders. National Institutes of Health, $207,388, 2009 – 2011.

Feig DS (Principal Investigator); Armson BA, Asztalos EV; Fantus, Ivan G, Lee, SK, Lipscombe L, Murphy KE, Ohlsson A, Ryan EA, Tomlinson GA, Zinman B (Co- Investigators) Cohen H. The MiTY Trial (Metformin in Women with Type 2 Diabetes in Pregnancy). CIHR, Operating Grant, $1,735,119, 2010 – 2015.

68 Feig DS, Lipscombe LL, Booth GL., Shah BR, Ray JG, Lowe J. Hypertensive disorders of pregnancy and future risk of diabetes in affected women and their offspring. Canadian Diabetes Association Operating Grant, 2010-2012.

Ferguson, SE (PI), Clarke B, Aronson M, Bernardini M, Gallinger S, Oza A, Mackay H, Pollett A. Screening for Lynch Syndrome in women with endometrial cancer using predetermined clinicopathologic criteria: A prospective cohort study. Princess Margaret Hospital Foundation, $78, 082, February 2011 – February 2012.

Ferguson SE (PI), Urowitz S (Co-PI), Classens C (Co-PI). Development and validation of the modified sexual adjustment and body image scale in women with a diagnosis of gynecologic cancer (SABIS-G). Princess Margaret Hospital Foundation, $15,000, 2009 – 2010.

Ferguson SE (PI), Barbera L, Classen, C, Massey C, Urowitz S, Wiljer D (CIs). Development and validation of the Modified Sexual Adjustment and Body Image Scale in women with a diagnosis of gynecologic cancer (SABIS-G). Mount Sinai Hospital Obstetrics and Gynaecology Research Fund. Collaborators: Total Amount: 10,000, 2009 – 2010.

69 Friedman JM (Principal Investigator), Chitayat D. Canadian Molecular Cytogenetics Platform. Canadian Foundation for Innovation, $4,512,925, 2005 – 2010.

Gien L, Barbera L, Fyles A, Covens A, Khalifa M, Thomas G, Elit L, Rakovitch E, Sutradhar R, Raymond E (local PI). Vulvar cancer: Patterns of care. CCSRI, $353,000, 2010 – 2013.

Grace SL (PI), Suskin N, Arthur HM, Prior P, Reid R, Stewart DE (Co-Applicants). Comparing paper versus electronic transmission of cardiac rehabilitation summaries to primary care physicians: A multi-site multi-method study of information flow and content (the CR2DoC study). Canadian Institutes of Health Research, MOP-74431, $324,697, April 2008 – March 2011.

Gupta A (PI), Lee-Chong A, Allen L, Kives S, Traubici J (Co-Investigators). A pilot prospective study of measurement of ovarian function in adolescent females receiving cancer therapy. Comprehensive Cancer Center, Adolescent Transition Care Program. $50,000, July 1, 2009 – July, 2010 with extension to 2011.

Harris D (PI), Rogers IM (CI). A model for analyzing the role of extrinsic factors responsible for aging of the human immune system. NIH Eureka Grant, $960,000, $240,000 per annum, 2010 – 2014.

Hodgson D (PI), Greenblatt EM, Catton P, Sridhar S, Azad A (CIs), McArdle O. Fertility in young breast cancer survivors – a novel assessment of ovarian reserve. Canadian Breast Cancer Foundation, $330,391, March 2008 – March 2011.

Hodnett ED, Stremler RL (PIs), Halpern SH, Willan AR, Windrim R (CIs). Labour Position Trial 2. CIHR, Operating Grant Priority Announcement, $100,000, March 2010 – February 28, 2011.

Hornberger LK(PI), Jain V, Ryan G (CIs). Twin-to-Twin Transfusion Syndrome: Pathogenic mechanisms & relevance to congenital heart disease. Planning Grant, $19,953, January 1, 2010 – December 31, 2010.

Janssen P, Lee SK. Antepartum Care of High Risk Pregnancy Team. Canadian Institutes of Health Research, $213,000, 2008 – 2011.

71 Jurisica I, Oza AM (Principal Investigators), Colgan TJ, Jurisicova A, Kislinger T (Co- Applicants). Diagnostic and prognostic biomarkers for epithelial ovarian cancer. Canadian Institutes of Health Research, Operating Grant, $734,532 total, $161,125 per annum, 2009 – 2013.

Jurisicova A. Canada Research Chair. CIHR, $175,000, July 1, 2008 – June 30, 2013.

Jurisicova A (PI), Casper RF (CI). Role of Pdss2 in oocyte aging. Canadian Institutes of Health Research, Catalyst Grant - Pilot Projects in Aging, $50,000, March 2011 – February 2012.

Jurisicova A. Mouse models of ovarian cancer. Grant Miller Research Foundation, $20,000, 2008 – 2012.

Keunen J, Woleve T, Southgate K. The effect of a low glycemic index diet on blood sugar control in pregnancy women at risk for gestational diabetes. September 2009 – September 2011.

Kingdom J (PI). Placental response to heparin: Implications for the prevention of pre-eclampsia. Physicians’ Services Inc., Ontario. $169,000, April 2011 – March 2012.

Kingdom J (PI). Screening for placental health in nulliparous women. AFP-UHN/Mount Sinai. $193,000, July 2010 – June 2013.

Kingdom J, Walker M, Rodger M (CIs). TAPP: Thrombophilia and Placental Pathology. Canadian Institutes of Health Research, $582,543, September 2007 – August 2010.

Kingdom J, Walker M, Rodger M (CIs). TAPP: Thrombophilia and Placental Pathology. Heart and Stroke Foundation of Canada, $340,000, September 2007 – August 2010.

Kingdom J (PI) “HEPRIN” trial. Physicians’ Services Inc. Foundation, $122,000, September 2007 – August 2010.

Kingdom JCP (PI), Keating S, Cross J, Dunk C (Co-Applicants).Villous trophoblast turnover. Canadian Institutes of Health Research Award, $538,888, October 2006 – September 2010.

Kingdom JCP (PI), Keating S, Cross J, Dunk C (Co-Applicants).Villous trophoblast turnover. Canadian Institutes of Health Research Award, $593,799, Renewal, October 2010 – September 2014.

72 Kives S. Randomized controlled trial of continous oral contraceptives vs. cyclical oral contraceptives in adolescents. Physicians’ Services Inc. Foundation, $75,000, 2005 – present.

Koren G (PI), Chitayat D, Ito S, Madadi P (CIs). The GeneMed Program. Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children. McLaughlin Centre Accelerator Grant Competition, $60,000, 2011 – 2012.

Lee SK. Maternal Infant Care (MICare) Research. Ontario Ministry of Health & Long Term Care, $15,000,000, 2009 – 2013.

73 Leyland N (PI). FAST Trial multicentre trial of intrauterine ultrasound-guided radio-frequency ablation of myomata. GYNESONICS, $2,500,000, 2009 – 2011.

Librach CL, Kingdom JC (PIs). Prediction of preeclampsia using an HLA-G gene single nucleotide polymorphism (SNP). Canadian Institutes of Health Research, Operating Grant, $266,337, September 2008 – August 2011.

Lilge L, Derzko C. Use of optical breast spectroscopy to evaluate short-term (early) breast tissue changes in post-menopausal women initiating menopausal hormone therapy. Total operating budget: $90,000, 2010 – ongoing.

Loutfy MR, De Pokomandy A, Hogg RS, Kaida AK (PI); Anema A, Angel JB, Baril J-G, Brophy JC, Brotto LA, Gahagan JC, Hankins CA, Kaushic C, Klein MB, Leonard LE, Lima VD, Lloyd-Smith EM, Miller C, Money DM, Ogilvie GS, Palmer A, Pick N, Raboud JM, Rachlis AR, Roth E, Rouleau D, Rourke SB, Tharao WE, Tremblay CL, Trottier B, Trottier S, Tsoukas CM, Walmsley SL, Yudin, MH (CI). Canadian HIV Women and Reproductive Health Cohort Study, a Canadian Observational Cohort (CANOC) Affiliated Study. Canadian Institutes of Health Research (CIHR), Operating Grant, $1,192,492, 2010 – 2015.

Loutfy MR, Serghides L, Yudin MH (PI); Bilsborrow PP, Doolittle-Romas M, Ion A, Katherine W, Leader A, Linklater Gail, Maggi JD, Margolese SL, Masinde KI, Maxwell JD, Mcgee F, Muchenje M, O'Brien-Teengs D, Doris J; Peltier DJ, Ringlein M, Said T, Sandre R, Sharp M, Tharao WE, Angel J, Bayoumi A, Bitnun S, Brophy J, Calzavara L, Carvalhal A, Greene S, Gruslin A, Hamilton G, LaPorte C, Lye S, Murphy K, Newmeyer T, Raboud J, Rachlis A, Ralph E, Rosenthal K, Shapiro H, Shynlova O, Silverman M, Smaill F, Smith M, Walmsley S, Wobeser W (Collaborators). Interdisciplinary HIV pregnancy research group: Care and research to optimize HIV-positive women’s health during preconception, pregnancy and motherhood. Canadian Institutes of Health Research (CIHR), Emerging Team Grant: Maternal Health, From Pre-conception to the Empty Nest, $900,000, 2011 – 2014.

Lye SJ. Fetal, neonatal and maternal health. CIHR, Tier 1 Canada Research Chairs Program, Operating Grant, $1,400,000; $200,000 per annum, July 1, 2008 – June 30, 2015.

Lye SJ (PI), Adams L, Beilin L, Briollais L, Matthews S, Newnham J, Olynyk J, Palmer L, Pennell C. Gene environment interactions underlying DOHaD. Canadian Institutes of Health Research, Operating Grant, $876,529; $175,306 per annum, April 1, 2010 – March 31, 2015.

74 Lye, SJ (PI), Adamson L, Matthews SG. Pennell CE (Co-Investigators). A murine model to investigate the mechanisms underlying DOHaD. CIHR, Operating Grant, $910,852, ($182,170 per annum), October 2009 – September 2014.

Lye SJ (PI), Challis J, Dong X. Progesterone signalling during pregnancy and labour. Canadian Institutes of Health Research. Operating Grant, $798,107; $159,621 per annum, January 1, 2011 – March 31, 2016.

Lye SJ (Principal Investigator), Dunk C, Keating S, Maxwell C. Extravillous trophoblast mediated utero-placental vascular remodelling. Canadian Institutes of Health Research, Operating grant, $713,265; $142,653 per annum, April 1, 2007 – March 31, 2012. Lye SJ (Principal Investigator), Langille L. Myometrial programming: A new concept underlying the control of myometrial contractility during pregnancy. Canadian Institutes of Health Research, Operating grant, $727,080 total, $145,416 per annum, October 1, 2005 – September 30, 2010.

Lye SJ (PI), Pennell C, Shynlova O. Peripheral leukocytes as targets for preterm birth prevention. March of Dimes Birth Defects Foundation, Operating Grant, $482,300 U.S, $160,767 U.S. per annum, March 1, 2010 – February 28, 2013.

Lye SJ (Principal Investigator), Shynlova O (Co-Investigator). Control of myometrial contractile activity during pregnancy. CIHR, Operating Grant, $912,320, $175,306 per annum, 2010 – 2015.

Magee LA (PI); Armson BA, Asztalos EV, Gafni A, Gruslin AMR, Helewa ME, Hutton EK, Lee SK, Logan AG, Moutquin Jean-Marie, Murphy KE, Rey EE, Ross SJ, Singer J, von Dadelszen P (CIs), Seaward PGR (Collaborator). CHIPS Control of Hypertension in Pregnancy Study. Canadian Institutes for Health Research, $3,743,575, $710,586 2010-2011, July 2008 – June 2013.

Matthews SG (PI). Multidrug resistance in the developing brain barrier: Fetal brain protection. Canadian Institutes of Health Research, Operating Grant, $449,548 total, $112,387 per annum, 2007 – 2011.

75 Matthews SG (PI). Trangenerational effects of antenatal glucocortocoid treatment: Mechanisms of programming. CIHR, Operating Grant, $479,331, $159,777 per annum, October 1, 2009 – September 30, 2012.

McCulloch C(PI) , Brown TJ, Ringuette M. Bone sialoproteins in skeletal metastasis. CIHR, Operating Grant, $430,822, 2008 – 2011.

McGeer AJ (Principal Investigator), Allen VM, Bujold E, Coleman BL, Drews SJ, Johnstone J, Lee BE, Levy M, Loeb MB, Louie M, Manos SH, Mcneil SA, Money DM, Murphy KE, Sermer M, Taylor G, Zahariadis G. Outcomes of Pandemic Influenza in Pregnancy (OPIP). CIHR, Catalyst Grant: Pandemic Outbreak Research Response, $395,825, October 1, 2009 – September 30, 2010.

McKenzie K (PI), Noh, S., et al., Stewart DE. (Co-Applicants). Strategic training program for the social etiology of mental illness. Canadian Institutes of Health Research, $1,790,000, 2009 – 2015.

Meffe F (PI), Biringer A, Caccia N, Espin S, Sharpe M, Van Wagner V, Moravac C(CIs). Developing, implementing and evaluating an Interprofessional Collaboration in Maternity Care Program (for practicing health care professionals): A Pilot Project. Canadian Protective Medical Association, Grant, $50,000, April 2011 – August 2012.

Money DM, Bocking AD, Hemmingsen SM, Hill JE, Reid G (PIs); Dumonceaux TJ, Gloor GB, Links MG, O'Doherty KC, Tang PK, Van Schalkwyk JE, Yudin MH (CIs). Vaginal Microbiome Project Team Workshop. Planning Grant, CIHR, $24,307, 2010 – 2011.

Money DM, Bocking AD, Hemmingsen SM, Hill JE, Reid G (PIs); Dumonceaux TJ, Gloor GB, Links MG, O'Doherty KC, Tang PK, Van Schalkwyk JE, Yudin MH (CIs). The Vaginal Microbiome Project Team. Emerging Team Grant: Canadian Microbiome Initiative, CIHR, Operating Grant, $1,745,340, September 2010 – August 2015.

76 Munjanja SP, Thistle P, Magwali T, Manase M, Madziyire G, Zvandasara P, Magure T, Marume A, Chipato T, Mushangwe V, Kasule J, Rusakaniko S, Kawanzaruwa W, Malunga G. Maternal and perinatal mortality prevention of mother to child transmission. Department for International Development (United Kingdom), $640,117 US, 2007 – 2017.

Narod SA (PI), Ghadirian P, Malkin DD (CIs). Genetic susceptibility to esophageal cancer. Canadian Institutes of Health Research, Operating Grant, $552,132, 2008 – 2011.

Narod S. BRCA1, BRCA2 and ovarian cancer survivorship. Canadian Cancer Society Research Grant. 2009/2010: $131,648; 2010/2011: $86,394, 2009 – 2011.

Narod SA (Principal Investigator), Bristow RG, Nam RK, Trachtenberg J (Co-Investigators). Clinical Course of BRCA2-associated prostate cancer. CIHR Operating Grant, $425,989, 3 years, 2009 – 2012.

Narod S. Risk factor analysis of hereditary breast and ovarian cancer. Canadian Breast Cancer Research Alliance Operating Grant. $297,900 per annum, $1,489,500 total, 2009 – 2014. Nulman I (PI), Koren G, Barrera M, Warner E, Maxwell C, Sermer M, Tozer R, Madarnas Y, Brezden-Masley C, Sridhar S, Colapinto N (CIs). Neurodevelopment of children exposed in utero to chemotherapy for maternal breast cancer. Canadian Breast Cancer Foundation. $436,570 total, $145, 419 per annum, 2010 – 2013.

Olson D (Principal Investigator), Bocking AD. Preterm birth and healthy outcomes. Alberta Heritage Foundation for Medical Research (AHFMR), $1,000,000 per annum, 2008 – 2012.

Olson D, Trough S (PIs), Bocking AD, Lee SK (CIs) Preterm birth and healthy outcomes. AHFMR, $5,000,000, January 2008 – December 2013.

Oyewumi L (PI), Kingdom J, Carvalho J (Co-Supervisors), Non-invasive hemodynamic monitoring using bioreactance technology in pregnant women at high risk of developing preeclampsia. Mount Sinai Hospital, Research Foundation, Department of Obstetrics & Gynaecology, $5,000, July 2010 – June 2011.

77 Pawson A(PI); Lye S, et al. (CIs) Ontario Proteomics Methods Centre (OPMC) (Project # is RE01-044). Ontario Research Fund. Overall ORF contribution (including overhead) is $4,526,986. Total project including match is $13,582,282. Lye portion of ORF contribution (excluding overhead) is $480,000. Lye portion of project including match is $992,600, October 1, 2006 – March 31, 2011.

Retnakaran RR (PI), Connelly PW, Hanley AJ, Sermer M, Vieth R, Zinman B (CIs). Vitamin D and the early pathophysiology of type 2 diabetes in women with a history of gestational diabetes. $98,483, April 1, 2011 – March 31, 2012.

Ringuette M (PI), Brown TJ, Gariepy J, Petrik J, Murphy KJ. Development of SPARC mimetic peptides for targeting peritoneal metastasis of epithelial ovarian cancer. Collaborative Health Research Projects, $461,097, April 2011 – March 2014.

Roberts SW, Loh A, Roberts W, Anagnostou E, Marcon M, Weiss S, Brian, Feigenbaum A, Schulze A, Logan W, Chitayat D, Weksberg R, Green P, Weiss J, Mitchell S, Berall G, Bradley E, Freeman N, Stinson J, Ornstein M, Atkinson A, Goldfarb C, Flanagan J, Superina D, Jiminez E, Jones Stokreef N, Orsino A, Isaacs B, Handley Derry M. Cooperative Multi-Center Program for Research and Treatment of Autism. Autism Treatment Network, $420,000, 2011 – 2013.

Rodger, MA (PI), Abenhaim HA, Bates SM, Chan WS, Fergusson DA, James A, Kahn SR, Khalil H, Khurana R, Konkle B, Mcdonald SD, Mcleod AG, Ramsay TO (CIs), Cohen H (Collaborator). A pilot study assessing feasibility of a randomized, placebo-controlled trial of low-molecular-weight-heparin for postpartum prophylaxis in women at risk of developing venous thromboembolism (pilot PROSPER Trial: PostpaRtum PrOphylaxiS for PE Randomized Control Trial). CIHR, Operating Grant, $487,377, 2010 – 2011.

Rogers IM (PI). Differentiation of blood cells into insulin producing cells for the treatment of type 1 diabetes. MaRS Innovations, $65,000, 2009 – 2010.

Rogers IM (PI). Treatment of peripheral vascular disease with stem cells. Stem Cell Network Impact Grant, $75,000, 2009 – 2010.

78 Rogers IM (PI). Comparison of CD34+ cells versus CD34+ cultured cells in the treatment of PVD. MaRS – Proof of Principle. $50,000, 2010 – 2011.

Rogers IM (PI). Treatment of type 1 diabetes with stem cells. CIHR – Proof of Principle, $150,000, 2010 – 2011.

Rosen B, Woods B (Collaborator). Canadian synoptic reporting in Canada. Canadian Partners against Cancer, $243,000 per annum, 2008 – 2010.

Rossant J. Lineage development in the mouse blastocyst. CIHR, Operating Grant, $1,012,210, 2009 – 2014.

Rossant J (Principal Investigator). Transcriptional networks in trophoblast stem cell development. CIHR, Operating Grant, $1,049,389, 2010 – 2015.

Sears M, Subbarao PH, Sermer M (CIs), Herer E (Site Investigator). The Canadian Healthy Infant Longitudinal Development (CHILD) Study. Canadian Institutes of Health Research (CIHR). $3,127,941, 2007 – 2016.

Serghides L (PI), Loutfy MR, Murphy KE, Yudin MH. Angiogenesis and adverse pregnancy outcomes in women with HIV, a pilot study. CIHR, $95,710, March 1, 2010 – February 28 2011.

Sermer M (CI). Thrombophilia in Pregnancy Prophylaxis Study. Heart and Stroke Foundation of Canada, $2,671, 825 total, 2006 – 2011.

Sermer M (Co-Investigator). The impact of dietary factors on the pathophysiology of gestational diabetes and subsequent type 2 diabetes. Canadian Diabetes Association, $272,589, 2008 – 2011.

Sermer M (PI). MIREC Infant Development Study (MIREC FFQ). Health Canada, $35,000, 2010 – 2011.

Sermer M (PI). Food Frequency Questionnaire Validation Study – MIREC. Health Canada. $19,998, 2009 – 2011.

Sermer M (CI). Investigation of the prognostic importance of natiuretic peptides in pregnant women with heart disease: A prospective observational cohort study. Heart and Stroke Foundation of Ontario, $139,940, 2010 – 2012.

Silverman M, Thistle P. Effectiveness of Nelfinavir-based Haart in prevention of infant adverse events in a rural setting In Zimbabwe. The Rotary Foundation, $47,000 US, 2008 – 2012.

79 Silversides C, Siu SCB (PIs); Colman JM, Lee DS-Y, Natale R, Penava DA, Sermer M, Wald RM (CIs). Pregnancy and subsequent cardiovascular risk in women with heart disease. Canadian Institutes of Health Research (CIHR). $492,261, April 1, 2011 – March 31, 2014.

Spitzer RF (PI). Evaluation of emergency obstetric training program in Western Kenya. Mount Sinai Hospital, Research Fund. $9,000, 2010 – 2011.

Spitzer RF (PI), Allen LM (Collaborator). Use of ACASI to gather information on risk behaviours in a referral population of pregnant Canadian adolescents. Physicians’ Services Incorporated Foundation, Grant, $37,800, 2011 – 2013.

Stevens B, Lee SK. CIHR Team in Children’s Pain. Canadian Institutes of Health Research. $4.7 million, 2006 – 2011.

Tai M (PI), Woods B, Badmos L, Murphy K(CIs) The development of a new Cesaerean section audit tool and the impact on cesarean section rate at TEGH.Ministry of Health, Responsible Physician Quality Improvement Project (MRP QIP).$16,000, 2011 – 2012.

Thistle P. Cervical cancer prevention and screening: Visual inspection of the cervix with acetic acid. Long term methods of family planning. Rotary Club of Toronto Eglinton Foundation, $30,000, 2010 – 2012.

80 Tremblay L, Bakirtzian A, Benhabib B, Ternamian A (Principal Investigators), Tyrwhitt J. Interdisciplinary collaborative robotic automated port application research. Department of Kinesiology, the Division of Gynecologic Endoscopy, Department of Obstetrics and Gynecology and the Department of Research and Knowledge Management at St. Joseph's Health Centre, Department of Clinical Biomedical Engineering, University of Toronto, $5000 and in kind donations, December 2007 – December 2010.

Weksberg R (PI), Keating S, Kingdom J, Chitayat D. Epigenetic programming and genome function during development – IUGR as a model system. CIHR, $127,961 per annum, 2008 – 2011.

Weksberg R (PI), Roberts W, Scherer S. Genome-wide DNA methylation profiling in Autism. Canadian Institute of Health Research, $593,815, 2008 – 2011.

Wen, Shi Wu (Principal Investigator), Coyle DA, Davidge ST, Fergusson DA, Fraser WD, Kingdom JC, Lee, SK, Perkins SL, Smith GN, Walker MC, Wells GA (Co-Investigators). Sermer M, Cohen H (Collaborators).Effect of folic acid supplementation in pregnancy on preeclampsia (FACT). CIHR Randomized Controlled Trials Program, $6,413,579 Operating; $34,844 Equipment, October 1, 2009 – September 30, 2014.

Whittle W, Baud D. The role of new chlamydia-like bacteria in the endometrium of patients with previous adverse pregnancy outcomes. Mount Sinai Hospital Department of Obstetrics and Gynaecology Research Award, $7, 150, 2011.

Whittle W, Kfouri J. Preterm Premature Rupture of the Membranes: What is the effect of latency on neonatal outcome? Mount Sinai Hospital Department of Obstetrics and Gynaecology Research Award, $1,000, 2011.

Windrim R (PI), Seaward PGR, Lausman A, Pittini R (Collaborators). Development of a training program to teach teachers how to implement a simulation-based curriculum in obstetric emergencies for interprofessional teams. University of Toronto, $14,810, 2008 – 2011.

Windrim R. (CI). Comparison of continuous intravenous remifentani vs. intermittent fentanil- midazolam bolus for analgesia in fetal endoscopic techinques. University of Toronto, Mount Sinai Hospital, $4,000, July 2010 – June 2011.

81 Wolever TMS, O'Connor D, Josse RG, Feig DS, Ray JG, El-Sohemy A. The effect of a low glycemic index (GI) diet on maternal and neonatal markers of glycemic control and post-partum diabetes risk. Canadian Diabetes Association, 2010 – 2013.

Yudin M (Collaborator). Mechanism of aging following exposure to HIV antiretroviral drugs. Canadian Institutes of Health Research (CIHR), $485,586, Emerging Team Grant, 2007 – 2012.

Yudin M (PI); Sgro MD, Campbell DM, Lee S, Sankaran K, Tran D (Collaborators). Maternal intrapartum antibiotic use and the prevention of early-onset neonatal sepsis. St. Michael’s Hospital AFP Innovation Funds, $42,000, 2011.

Zuniga-Pflucker, JC (PI), Herer E (Collaborator) Generation of human progenitor T cells with immune-reconstituting potential. CIHR Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream, $439,578, 2011 – 2014.

82 RESEARCH GRANTS 2011-2012

PI=Principal Investigator; CI=Co-Investigator

Alarab M (PI). Expression of Procollagen N Proteinase in the Vaginal Tissue of Women with and without Pelvic Organ Prolapse. $10 000, July 2011.

Auger J, Baillargeon J-P, Beli (PIs); Carranza-Mamane B, Greenblatt E, Hivert M-F, Langlois M-F, Lavoie HB, Pesant M-H, Poder TG (CIs). Evaluation of clinical outcomes and costs of a transferable interdisciplinary lifestyle intervention pre-and per-pregnancy in obese infertile women. CIHR and Quebec Ministry of Health, Partnerships for Health System Improvement, FRN-114125. $345,500, July 2011 – June 2012.

83 Barbera L (PI), Gien L, Khalifa M (Co-Investigators). Vulvar carcinoma: A population-based analysis. Canadian Cancer Society Research Institute, $352,243 total; $152,915 first year, $140,445 second year, $58,883 third year, 2010 – 2013.

Belsham DD. Canada Research Chair Award in Neuroendocrinology, Tier 2, Renewal, $500,000, $100,000 per annum, July 2009 – June 2014.

Berger H. Abdominal visceral fat measured in early pregnancy and the risk of gestational diabetes mellitus. Canadian Institutes of Health Research, $100,000, July 2011 June 2012.

Bernardini M (PI), Gien L, Ferguson S, Murphy J, Rosen B (CIs) A prospective study evaluating surgical and quality of life outcomes after robotic surgery, laparoscopy, and laparotomy in the management of uterine and cervix cancer. AHSC, AFP Innovation Fund, 2010-2011: $91,910; 2011-2012: $92,699, $188,009 total, 2010 – 2012.

Bernardini M (Co-PI), Rouzbahman M, Haider M, Lindner U, Kucharczyk W. A Feasibility Study to Evaluate the Safety and Preliminary Effectiveness of Focal MR-Guided Focused Ultrasound Treatment of Low-risk, Early Stage 1 Low Volume Endometrial Cancer. Focused Ultrasound Surgery Foundation, $99,900 May 2012 – May 2013.

Brown TJ (PI). Novel functions of nuclear receptor coactivator 4 at the mitotic apparatus. Natural Sciences and Engineering Research Council of Canada (NSERC). $50,000, April 2011 – March 2016.

84 Brown TJ (PI), Ringuette M, Winegarden N. Androgen modulation of TGFβ signaling in ovarian cancer cells. CIHR Operating Grant, $598,000, 2009 – 2013.

Caniggia I (PI), Bhattacharjee J. The role of Mcl-1 in regulating placental cell fate. CIHR HOPE-Scholarship, Operating Grant, $112,000, 2011 – 2015.

Casper RF (PI). Brown TJ, Shapiro C. Prevention of circadian rhythm disruption by nocturnal lighting. CIHR, Operating Grant, $427,126 total, $142,375 per annum October 1. 2008 – September 30, 2011.

Church P, Lee S, et al. Academic challenges for the preterm infant: educator’s knowledge, attitudes and identified barriers to providing aid to this population. PSI , $61,000, 2011 – 2012.

85 Covens A, Carter J, Ali S (PIs). Non radical surgical therapy for Stage IA1-IB1 (≤ 2cm) cervical cancer. Division of Cancer Prevention, National Cancer Institute, 2011 – 2014.

Derzko CM (PI), Josse R. DHEA Against Vaginal Dryness (Placebo-Controlled, Double-Blind and Randomized Phase III Study of 3-Month Intravaginal DHEA). Endoceutics Protocol ERC- 234, $3,460 per patient, 2011 – 2012.

Diamandis E (PI), Bernardini MQ. An integrated systems biology approach for ovarian cancer biomarker discovery. NIH Sub-Award # 1U01CA152755-01, $42,000, September 2010 – August 2011.

Disaia P, Copeland L, Thigpen T, Alvarez R, Aghajanian C, Fracasso P, Birrer M, Hamilton T, Whitney C, Spirtos N, Miller D, Randall M, Waggoner S, Alberts D, Monk B, Koh W, Walker J, Bookman M, Rodgers W, Gershenson D, Covens A, Nolte S, Mannell R, Fleming G, Bell J, Brown C, Wenzel. NCI, GOG Operating Grant, $107,671,648 US, 2010 – 2015.

86 Feig DS, Lipscombe LL, Booth GL., Shah BR, Ray JG, Lowe J. Hypertensive disorders of pregnancy and future risk of diabetes in affected women and their offspring. Canadian Diabetes Association Operating Grant, 2010-2012.

Ferguson, SE, Classen C, Barbera L, Chivers M, Urowitz S, Wiljer D. An online support group for sexual distress due to gynecologic cancer: A randomized study. Canadian Institutes of Health Research (CIHR). $100,000, September 2011.

Flood C, Lee S, et al. Health Law, Ethics and Policy Training Program. Canadian Institutes of Health Research, $3,412,500, 2002-2015.

Gien L, Barbera L, Fyles A, Covens A, Khalifa M, Thomas G, Elit L, Rakovitch E, Sutradhar R, Raymond E (local PI). Vulvar cancer: Patterns of care. CCSRI, $353,000, 2010 – 2013.

Greenblatt E (PI); Chan C, Brown T, Winegarden N ,Virtanen C (CIs). Non-invasive genomic analysis of human endometrial receptivity. Physicians’ Services Incorportion, Resident Research Grant, $20,000, January - December 2012.

Haider M (PI), Toi A, Sweet J,. O’Malley M, Trachtenberg J. The utility of functional and morphologic MRI in the detection of prostate cancer for patients with elevated PSA and prior negative biopsy. Princess Margaret Hospital Foundation, $30,000, April 2002 – present.

87 Harris D (PI), Rogers IM (CI). A model for analyzing the role of extrinsic factors responsible for aging of the human immune system. NIH Eureka Grant, $960,000, $240,000 per annum, 2010 – 2014.

Jarvi K (PI), Diamandis E, Finelli A, Fleshner N, Zlotta A (Co-applicants); Briollais L, Grober E, Ghai S, Lo K, Margolis M, Mullen B, O’Malley M, Tannenbaum D, Toi A, van der Kwast T. Semen Proteomics to Identify Novel Prostate Cancer Biomarkers. Canadian Cancer Society Research Institute (CCSRI), $413,853, July 2010 – June 2013.

Jurisicova A. Canada Research Chair. CIHR, $175,000, July 1, 2008 – June 30, 2013.

Jurisicova A (PI). Maternal obesity and oocyte health. Canadian Foundation for Women’s Health. Operating Grant. $17,000, July 2012 – June 2013.

88 Jurisicova A (PI). Role of Mcl-1 in ovarian biology. Canadian Institutes of Health Research (CIHR). Operating Grant, $142,000 CAD, 2012 – 2017.

Jurisicova A (PI), Casper RF (CI). Role of Pdss2 in oocyte aging. Canadian Institutes of Health Research, Catalyst Grant - Pilot Projects in Aging, $50,000, March 2011 – February 2012.

Jurisicova A. Mouse models of ovarian cancer. Grant Miller Research Foundation, $20,000, 2008 – 2012.

Keely EJ (PI). Feig DS, Gagnon R, Sermer M. (CIs). Translating New Evidence into Practice for Women with Gestational Diabetes. Canadian Institutes of Health Research, Meetings Planning & Dissemination Grant. $9,500, July 2011 – June 2012.

Keunen J, Woleve T, Southgate K. The effect of a low glycemic index diet on blood sugar control in pregnancy women at risk for gestational diabetes. September 2009 – September 2011.

Kingdom J (PI), Keating S (CI). Placental response to heparin: Implications for the prevention of pre-eclampsia. Physicians’ Services Inc., Ontario. $169,000, April 2011 – March 2012.

Kingdom J (PI). Screening for placental health in nulliparous women. AFP-UHN/Mount Sinai. $193,000, July 2010 – June 2013.

Kingdom JCP (PI), Keating S, Cross J, Dunk C (Co-Applicants).Villous trophoblast turnover. Canadian Institutes of Health Research Award, $593,799, Renewal, October 2010 – September 2014.

Kingdom J, Balki M, Carvalho J. Optimizing contractility in human myometrium using a combination of Uterotonic agents: An in-vito approach to improving treatment options for primary-post partum hemorrhage. MSH Research Foundation, Department of Obstetrics & Gynaecology. $5,000, July 2011 – June 2012.

Kislinger T (PI), Bernardini M (CI), Ailles L, McGill P, Clarke B. Glycoprotein biomarkers for ovarian cancer. Canadian Cancer Society Research Institute - Innovation Grant, $200,000, May 2012 – May 2013.

Kives S. Randomized controlled trial of continous oral contraceptives vs. cyclical oral contraceptives in adolescents. Physicians’ Services Inc. Foundation, $75,000, 2005 – present.

89 Kotsopoulos J (PI), Narod S (CI). Risk Factor Analysis for Familial Breast Cancer. Canadian Breast Cancer Foundation, Research Project Grant. $447,312, January 2011 – December 2013.

Lee SK. The Women’s Auxiliary Chair in Neonatology. The Hospital for Sick Children, $350,000, 2009 – 2013.

Lee SK. Maternal Infant Care (MICare) Research. Ontario Ministry of Health & Long Term Care, $15,000,000, 2009 – 2013.

Lee SK, James A, et al. Creating an innovative problem oriented documentation system to enhance clinical documentation for Level 3 NICUs. AHSC AFP, $200,000, 2011 – 2013.

Lee S, Shah V, et al. GentleR Study: a cluster randomized controlled trial. Lee S, AHSC AFP,$200,000, 2011 – 2013.

90 Levitan RD (Principal Investigator), Davis C, Kennedy JL, Loucks EB, Matthews SG, Meaney MJ, Soares CD, Steiner MA (Co-Investigators). Longitudinal study of food reward and obesity in young children: The role of gene-environment interaction. Canadian Institutes of Health Research, Operating Grant, $156,078 per annum, $780,390, 2009 – 2014.

Lispcombe L (PI), Lowe J, Feig D, Ray J, Booth G, Evans M (CIs). Improving Postpartum Screening for Women with Previous Gestational Diabetes Mellitus. Academic Health Sciences Centres, Alternative Funding Plans Innovation Funds. $29,516, July 2011 June 2012.

Loutfy M (PI), Interdisciplinary HIV Pregnancy Research Group (Shapiro H). Care and research to optimize HIV-positive women’s health during preconception, pregnancy and motherhood. CIHR, $300,000, July 2011 – June 2014.

Lye SJ. Fetal, neonatal and maternal health. CIHR, Tier 1 Canada Research Chairs Program, Operating Grant, $1,400,000; $200,000 per annum, July 1, 2008 – June 30, 2015.

Lye SJ (PI), Adams L, Beilin L, Briollais L, Matthews S, Newnham J, Olynyk J, Palmer L, Pennell C. Gene environment interactions underlying DOHaD. Canadian Institutes of Health Research, Operating Grant, $876,529; $175,306 per annum, April 1, 2010 – March 31, 2015.

Lye SJ (PI), Shynlova O (Co-Investigator). Control of myometrial contractile activity during pregnancy. CIHR, Operating Grant, $912,320, $175,306 per annum, 2010 – 2015.

Lye SJ (PI), Kingdom J, Caniggia I, Tough S, Lyon A, Slater D (Co-PIs). Predictive Biomarkers of Preeclampsia. McLaughlin Centre (Accelerator Grant), $50,000 May 2012 – April 2013.

Lye SJ (PI); Co-PIs: Barr C, Briollais L, Corter C, Fleming A, Jenkins J, Kennedy J, Lee S, Levitan R, Matthews S, Palmer L, Pascal C, Sokolowski M; Collaborators: Pennell C, Steiner M. Developmental Trajectories: A University of Toronto System-Wide Initiative to Improve Health, Learning and Society. Connaught Global Challenge (University of Toronto), Total: $1,000,000, $500,000 per annum. July 2011 – June 2013.

McKenzie K (PI), Noh, S., et al., Stewart DE. (Co-Applicants). Strategic training program for the social etiology of mental illness. Canadian Institutes of Health Research, $1,790,000, 2009 – 2015.

McKerlie C (PI), Brown S; Adamson SL, Bubela T, Rossant J, Weaver T (Co-Applicants). In vivo models for human disease and drug discovery. Genome Canada, Operating grant. $4,900,000, July 2011- June 2014.

Meyer, R, Oza AM (CI). CCS Clinical Trials Group, Canadian Cancer Society Research Institute. $36,992,840, July 2010 – June 2015.

Munjanja SP, Thistle P, Magwali T, Manase M, Madziyire G, Zvandasara P, Magure T, Marume A, Chipato T, Mushangwe V, Kasule J, Rusakaniko S, Kawanzaruwa W, Malunga G. Maternal and perinatal mortality prevention of mother to child transmission. Department for International Development (United Kingdom), $640,117 US, 2007 – 2017.

Narod SA (PI). The impact of pregnancy on survival after breast cancer in carriers of BRCA1 and BRCA2 mutations. Canadian Breast Cancer Foundation, Research Project Grant, $309,816, July – June 2011.

93 Narod SA (Principal Investigator), Bristow RG, Nam RK, Trachtenberg J (Co-Investigators). Clinical Course of BRCA2-associated prostate cancer. CIHR Operating Grant, $425,989, 3 years, 2009 – 2012.

Narod SA. Risk factor analysis of hereditary breast and ovarian cancer. Canadian Breast Cancer Research Alliance Operating Grant. $297,900 per annum, $1,489,500 total, 2009 – 2014.

Narod SA(PI). Casper RF, Kotsopoulos J, Wheeler AR. The physiological impact of postmenopausal oophorectomy on hormone levels in women with BRCA1 mutation. CIHR - NSERC partnered, Collaborative Health Research Projects. $412,769, June 2012 – May 2015.

Olson D, Trough S (PIs), Bocking AD, Lee SK (CIs) Preterm birth and healthy outcomes. Alberta Heritage Foundation for Medical Research (AHFMR), $5,000,000, January 2008 – December 2013.

Oza AM (PI), Siu L, Chen E, Moore M. The PMH Phase II Consortium - Early Therapeutics Development with Phase II Emphasis. National Institutes of Health/National Cancer Institute (USA), Contract: HHSN261201100032S, N01CM-2011-00032

Oza AM (PI), Mackay H. Molecular determinants of outcome with mTOR inhibition in endometrial cancer. Ontario Institute for Cancer Research, Small Projects, 071105. ,$68,790, July 2011 – June 2012.

Reedijk M, Oza AM (CI). Quantifying the Effect of Notch Inhibition on Tumor-Initiating Cells in Early Phase Trials of Gamma-Secretase Inhibitor (RO4929097) in Advanced, Triple Negative Breast Cancer and Other Solid Tumors. High Impact Clinical Trials Program, HICT-RFP0909- 04. $780,000, January 2010 – December 2011.

94 Roberts SW, Loh A, Feigenbaum A, Weiss S, Marcon C, Goldfarb C, Berall G, Bradley E, Brian J, Freeman N, Atkinson A, Taylor M, Stinson J, Mitchell S, Green P, Chitayat D. Funding of an autism intervention research network for physical health. Health Resources and Services Administration (HRSA) Award, $408,000, 2011 – 2013

Rosenblum N, Lee S. Canadian Child Health Clinician Scientist Program. Canadian Institutes of Health Research, $4,500,000, 2002 – 2015.

Rossant J. Lineage development in the mouse blastocyst. CIHR, Operating Grant, $1,012,210, 2009 – 2014.

Rossant J (Principal Investigator). Transcriptional networks in trophoblast stem cell development. CIHR, Operating Grant, $1,049,389, 2010 – 2015.

Sabri K, Lee S, et al. The First National Retinopathy of Prematurity Survey: Formulating Evidence-Based Screening Recommendations. Canadian Institute of Health Research, $349,983, 2011 – 2014.

Silverman M, Thistle P. Effectiveness of Nelfinavir-based Haart in prevention of infant adverse events in a rural setting In Zimbabwe. The Rotary Foundation, $47,000 US, 2008 – 2012.

Silversides C, Siu SCB (PIs); Colman JM, Lee DS-Y, Natale R, Penava DA, Sermer M, Wald RM (CIs). Pregnancy and subsequent cardiovascular risk in women with heart disease. Canadian Institutes of Health Research (CIHR). $492,261, April 1, 2011 – March 31, 2014.

Stevens B, Lee S. et al. Sustainability of a multidimensional knowledge translation intervention to improve paediatric pain practices and outcomes. Canadian Institute of Health Research, $822,401, 2011 – 2015.

von Dadelszen P, Lee S, et al. Clinical prediction models for critically ill pregnant women: MEOWS and CIPHER. Canadian Institute of Health Research, $100,000.00, 2011 – 2012.

96 Windrim R (PI), Seaward PGR, Lausman A, Pittini R (Collaborators). Development of a training program to teach teachers how to implement a simulation-based curriculum in obstetric emergencies for interprofessional teams. University of Toronto, $14,810, 2008 – 2011.

Wolever TM (PI). Barre DE, Darling PB, Feig DS, Josse RG, Lowe JM, Luthra M, O’Connor DL, Ray JG, Thorpe KE. (Co-investigators).The effect of a low glycemic index (GI) diet on maternal glycemic control and maternal and neonatal markers of postpartum diabetes risk in women with gestational hyperglycemia. Operating Grant. CIHR, $444,989, July 2011 – June 2014.

Yudin M (Collaborator). Mechanism of aging following exposure to HIV antiretroviral drugs. Canadian Institutes of Health Research (CIHR), $485,586, Emerging Team Grant, 2007 – 2012.

Yudin M (PI)., MacGillivray J, Newmeyer T, Loutfy MR. A qualitative evaluation of The Positive Pregnancy Program: An interprofessional multidisciplinary program for the care of HIV-positive pregnant women. AIDS Bureau, Ontario Ministry of Health and Long-Term Care, $25,000, 2012 – 2013.

Yudin M (PI ), Campbell DM, Freire-Lizama T, Sgro M, Barozzino T. Perinatal resuscitation training: A quality improvement project. St. Michael’s Hospital AFP Innovation Funds, $21,500, 2012 -- 2014.

Yudin M (PI ), Loutfy MR, Serghides L, Angel J, Bayoumi A, Bitnun S, Brophy J, Calzavara L, Carvalhal A, Greene S, Gruslin A, Hamilton G, LaPorte C, Lye S, Murphy K, Newmeyer T, Raboud J, Rachlis A, Ralph E, Rosenthal K, Shapiro H, Shynlova O, Silverman M, Smaill F, Smith M, Walmsley S, Wobeser W. Interdisciplinary HIV pregnancy research group: Care and research to optimize HIV-positive women’s health during preconception, pregnancy and motherhood. Emerging Team Grant: Maternal Health, Canadian Institutes of Health Research (CIHR), $900,000.00, 2011 – 2013.

97 Zinman B, Retnakaran RR, Hanley AJG, Sermer M, Connelly PW. Role of the arginine/nitric oxide metabolome in the early natural history of cardiovascular disease in young women with varying degrees of glucose intolerance in pregnancy. Canadian Diabetes Association, 2010 – 2013.

98 5.3 Appendix: Department Total Grants 2007-2011 By Source

TriCouncil Other Industry CFI* TOTALS

TOTAL 2007$ 3,528,659.00 $ 2,432,757.48 $ 721,719.89 $ - $ 6,683,136.37 TOTAL 2008$ 5,056,750.00 $ 2,352,576.44 $ 738,575.78 $ - $ 8,147,902.22 TOTAL 2009$ 3,935,296.96 $ 2,788,442.94 $ 58,500.96 $ 1,770,791.00 $ 8,553,031.86 TOTAL 2010$ 3,792,983.00 $ 3,496,677.31 $ 72,773.05 $ 2,411,023.00 $ 9,773,456.36 TOTAL 2011$ 3,640,489.00 $ 4,267,696.45 $ 64,332.50 $ 6,916,822.00 $ 14,889,339.95

TOTAL 2007-2011 $ 19,954,177.96 $ 15,338,150.62 $ 1,655,902.18 $ 11,098,636.00 $ 48,046,866.76

*Canadian Foundation for Innovation

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6. Organization and Financial Structure

The Department of Obstetrics and Gynaecology is a large multi-sited organization and therefore relies heavily on a clear administrative structure and communication strategy. (See Appendix 6.1 Organization Chart) The Department is supported by a number of Standing Committees:

Executive Appointments Promotion Undergraduate Medical Education Residency Program Fellowship Directors Continuing Medical Education Faculty Development Research

The Chairs of the major Committees, as well as the Chiefs at the fully-affiliated hospital sites, serve on the Department Executive Committee, which meets monthly. In addition, the Leadership Council, which consists of all the Education, Clinical and Research leaders across all the sites, meets quarterly. This group was established in 2003 and the meetings include a component of Faculty Development, with 45 minutes devoted to an invited speaker (See Appendix 4.5.2 for a list of speakers) and 45 minutes for updates and discussion regarding important Department-wide issues). The attendance at these meetings has fallen off somewhat over the last few years and the reasons for this are currently being explored. In addition to the Chair, there are 2 Vice-Chairs (Research- S. Lye and Education – H. Shapiro). Each of the Education Committees, as well as the Research Committee, is supported by fulltime administrative staff and report monthly to the Executive. In addition, the Chair meets with the Chiefs of the fully-affiliated sites quarterly to discuss issues of common interest e.g. access to care, quality, resource allocation and recruitment.

One of the challenges over the last five years has been the Undergraduate and Postgraduate enrolment expansion. This has required a progressive increase in the Department administrative support for these programs to the current status of 2.5 FTE’s and will require careful monitoring in order to ensure that sufficient resources are made available to support these programs, particularly with the increased complexities associated with enhanced Integrated Education.

The Department’s overall budget is approximately $3.4 million per annum, with $650,000 of that consisting of external salary awards and hospital/individual recoveries. The major sources of revenue for the Department are the Base Budget from the University ($900,000 pa), T and R Funding ( $998,000), Postgraduate Expansion and BIU Funding ($325,000), plus a combination of support from Department Endowments, Industry Educational Partners and Hospital Department contributions.

The major expenditures are on Academic Salaries and Stipends, including mandatory benefits ($2.9 million), Administrative Salaries and Benefits ($360,000) and Operating Expenses ($256,000 ). The Department is fortunate to hold slightly more than $7 million in endowments, Cyclical Review Fall 2012 Self-Study 58

which support Academic Salaries and various programs. In addition, the Department has been successful in securing approximately $200,000 pa over the last 6 years in philanthropic support for the Global Health Programs. The Department has also been successful in establishing three endowments to support Residents enrolled in the Clinical Investigator Program, including the Walter Hannah Clinician Scientist funds, the TG Riley Fund and the Bernard Ludwig Fund based at Mount Sinai Hospital. These funds have proven to be extremely important in allowing the Department to increase the number of postgraduate trainees enrolled in the CIP program in a consistent fashion.

The fully-affiliated Hospital Practice Plans (MSH/UHN, SMH and SHSC) also provide salary/stipend and administrative support for Faculty and Staff based at the hospitals, as well as providing support for Faculty through the Ontario Academic Health Sciences Centre (AFP). Total funding for the Department’s academic enterprise from these sources exceeds the budget of the University Department as described by at least two-fold (~ $6 million). In addition, the Faculty of Medicine has recently been able to provide Teachers at the Community-affiliated sites with a modest stipend with funds negotiated with the MOHLTC. Each of the affiliated Hospitals provides important administrative support and infrastructure to ensure a high quality experience for both Undergraduate and Postgraduate trainees in Obstetrics and Gynaecology.

The greatest challenges for the Department over the next 3-5 years will be ensuring the “comparability” of educational experiences for Undergraduate Medical Students given the large component of teaching in our discipline which is conducted in an ambulatory setting. This requires significant hospital support at a time when acute care hospitals tend to be decreasing their involvement in ambulatory care. In addition, the support from the various Research Institutes is highly dependant upon philanthropic support which, in the current economic climate, is challenging. Nevertheless, the Department has been fortunate to have strong support from each of the fully-affiliated hospitals for the research mission, as well as education. Department of Obstetrics & Gynaecology University of Toronto

Chair Dr. A. Bocking Vice-Chair Vice-Chair Research Education Dr. S. Lye Dr. H. Shapiro

Executive Leadership Committee Council

EDUCATION ADMINISTRATION DIVISIONS

Gynaecologic Business Manager Oncology Ms A. Morrin Dr. B. Rosen Department Undergraduate Administrative Assistant Maternal-Fetal Education Ms C. Bird Medicine Dr. F. Meffe Dr. D. Farine Undergraduate Program Coordinator Reproductive Endo- Residency Program Ms J. Moniz crinology & Infertility Dr. D. Steele Dr. T. Brown Postgraduate Program Coordinator Paediatric & Adolescent Fellowship Programs Ms C. Sutherland Gynaecology Dr. H. Shapiro Dr. L. Allen

Continuing Medical Urogynaecology Education Dr. H. Drutz Dr. F. Weisberg

Faculty Development Dr. J. Blake

Educator Dr. K. MacRury

Rev. Aug 23, 2012 / CB

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7. Resources and Infrastructure

The academic home of the Department is based at 92 College, and with the expansion of the Educational Programs and addition of the Global Health Programs, we now occupy all of the space in the house (1,500 square feet).This has served the Department well as it is centrally located and all of the key personnel are located within the building. The House is old, however, and the cost of maintaining the building is significant. It is our understanding that the Department will be required to move to another location in the next few years, but this is yet to be determined. This will be an important consideration for the Department and the next Leadership.

As discussed previously, the Department relies heavily on resources provided by the affiliated hospitals to support its academic mission. The Department is extremely grateful for this. Cyclical Review Fall 2012 Self-Study 60

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8. Alumni and Advancement Programs

The Department has recently established an Alumni Council with Dr. Adrian Brown (Chief of the Department of Ob/GYN at NYGH) as the inaugural Chair of the Council.

As part of the Department and Faculty of Medicine’s mandate to increase engagement of former trainees, there will be a combined event involving our alumni, with a professional development component for all our faculty, including an awards ceremony. There has been a major investment in updating our alumni database for communication of this and ongoing university events.

Alumni Day will take place on November 7, 2012 at the Estates of Sunnybrook and the Department will celebrate its 125 years of existence, a wonderful opportunity to bring together the many Alumni of the Department (former Residents and Fellows) with current Faculty.

We are planning on hosting social events, such as a tour of the campus, a debate regarding residency training through the ages and esteemed speakers, including Dr. Catharine Whiteside, Dean of Medicine. There will be a new section of the University of Toronto’s Department of Obstetrics & Gynaecology website dedicated to alumni issues and news, with postings of alumni achievements. We hope that by more active engagement with our large and dispersed alumni, we can build contact networks for our current trainees for elective experiences, potential collaborations with our current University of Toronto faculty and involve alumni more fully in the ongoing events and campaigns of the Faculty of Medicine and University of Toronto in the future.

The Department also supports a partial FTE of a Senior Development officer within the Faculty of Medicine Advancement Office and a number of initiatives have been identified to be included in the soon-to-be launched Boundless Campaign for the Faculty, including Endowed Chairs, the AMPATH Global Health Program, as well as lectureships and fellowships.

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9. Internal and External Relationships

The Department works closely with a number of clinical and basic Departments within the Faculty of Medicine, as well as the Dalla Lana School of Public Health. These are evident through joint educational and research programs with many cross-appointments reflecting these dual contributions. In addition, there are important clinical partnerships at the hospitals, including Paediatrics, Anaesthesia, Medicine, Surgery, Medical Imaging, Urology, Radiation and Medical Oncology.

The Department has particularly strong linkages with the Department of Physiology, with many Department members supervising graduate students enrolled in the Department of Physiology programs. This has proven over the years to be a very effective and productive partnership and has resulted in joint appointments (eg. Dr. Evelyn Lambe). This could be a very important recruitment model to further develop given the recognition of the importance of multidisciplinary research in Reproductive and Perinatal Medicine.

The Department has a strong presence in three GTA Cancer Centres (Princess Margaret Hospital, Odette Cancer Centre and Credit Valley Hospital) and members of the Department play key leadership roles within Cancer Care Ontario.

The Department’s Faculty have, and continue to hold, major leadership roles at the Institutional , Regional, Provincial, National and International levels in virtually all of the subspecialty disciplines in Obstetrics and Gynaecology. These include the following:

INTERNATIONAL -President of the Society for Gynecologic Investigation- Dr. Stephen Lye -President of the Perinatal Research Society – Dr. John Kingdom -Secretary, North American Society for Pediatric and Adolescent Gynecology Board – Dr. Lisa Allen

NATIONAL -Chair, Royal College Specialty Committee in Ob/Gyn – Dr. Paul Bernstein -Chair, Royal College Specialty Committee in Gynaecologic Oncology – Dr. Al Covens -President, Society of Obstetricans and Gynaecologists of Canada – Dr. Guylaine Lefebvre -President, Association of Academic Professionals in Obstetrics and Gynaecology (APOG) of Canada – Dr. Alan Bocking -President, Society of Gynecologic Oncology of Canada – Dr. Barry Rosen and Dr. Joan Murphy -Member, Society of Obstetricians and Gynaecologists of Canada Council – Dr. Wendy Wolfman

PROVINCIAL Chair, Ontario Ministry of Health and Longterm Care Prenatal Screening Subcommittee – Dr. Nan Okun Clinical Lead, Ontario Cervical Screening Program – Dr. Joan Murphy Member, Provincial Council on Maternal Child Health – Dr. Mathew Sermer

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Over the last 7 years, the Department has increased its participation in Global Health Programs and has used its membership in the AMPATH Consortium as a vehicle to enhance Clinical, Educational and Research programs at Moi University School of Medicine (MUSOM) and Moi Teaching and Referral Hospital in Eldoret, Kenya. Membership in this North American Consortium has facilitated bilateral exchanges of Faculty, Residents, and Medical Students, as well as Graduate Students in the Dalla Lana School of Public Health.

Since 2007, there have been 23 University of Toronto Undergraduate Medical and/or Public Health Graduate students; 7 Residents in Obstetrics and Gynaecology and 35 University of Toronto Faculty Exchanges to MUSOM and 18 MUSOM Faculty and 9 MUSOM student exchanges to Toronto.

The Department has recruited a Faculty Member who spends 9 months per year in Eldoret and is supported through a sub-grant from USAID through Indiana University as well as philanthropic support. In order for this program to have ongoing stability, it will be necessary to raise sufficient funds for an endowed Chair in Women’s Reproductive Global Health. The Department continues to apply for grants to support these initiatives and has been successful to date in securing both a Grand Challenges Canada Rising Star award to Dr. Christoffersen-Deb, as well as a Saving Lives at Birth Grant to MUSOM.

Department members are very active in various outreach initiatives, which have an important positive social impact (eg. ensuring access to safe family planning, advocacy for cancer care for women, infertility treatment as well as prenatal care for refugee women, to mention but a few ).

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10. Report of Faculty Members

As part of the Department review of the second term of the Chair, Dr Alan Bocking, a faculty survey was sent to all members of the Department of Obstetrics & Gynaecology. A committee consisting of generalists, subspecialists and community members of the Department prepared the survey to obtain anonymous and representative views and visions of the Faculty with regard to the Department. The survey was carried out by means of an online questionnaire.

This report is based on the response of 79 members of the Department to an anonymous survey sent in June 2012 to 220 faculty. There were seven statements for which we requested a response ranging from strongly disagree to strongly agree. One question was open-ended. The 36% response rate is similar to other U of T surveys done for the same purpose. Approximately 40% of the responders have been in the Department for fewer than 10 years, and 35% for more than 20. The large number of new members to the Department likely represents our new community affiliates, since 56 of the 220 faculty appointed in the last 4 years have been to a partially- affiliated hospital. Only 6 of the respondents have been members of the Department for 16-20 years. This reflects the small number (17) who joined during this time period.

Results of the survey are found in Table 1 below.

120

100

80 strongly agree

agree 60 disagree 40 strongly disagree

0 1234567

Table 1: Response to Department Faculty Survey Cyclical Review Fall 2012 Self-Study 66

Every member, save one, agreed or strongly agreed with the statement 1: My association with and the reputation of, the University of Toronto Department of Obstetrics & Gynaecology is important to me.

82% of the respondents agreed or strongly agreed with statement 2: There is a strong sense of community in the Department of Obstetrics & Gynaecology at University of Toronto.

Added comments often have bias toward more negative opinions. In this case, they served to qualify the positive opinions with statements such as “Generally yes, but fragmented into hospital affiliations”, “Some divisions [are] outright competitive.” There was a sense that community was stronger in the “academic” staff and while the sense of community was strong in the university Department, there was more community within hospitals than across the University.

Faculty members appear to be less content with regard to communication. 38% did not agree with Statement 3: The Department encourages and facilitates communication between sites. The comments related to this question were not helpful.

Most (80%) of the respondents agreed with Statement 4: The Department has a clear vision for its future and there is agreement with this vision by the faculty. Nonetheless, many were not clear themselves on the vision, or felt “there is a conflict between what hospital sites want and what might be best for the overall”.

The department as a whole agreed with Statement 5: The Chair understands the needs of the department’s members. It appears that several members, while agreeing with the statement, were not completely sure. Many who answered “agreed” qualified this with responses such as “I’m not sure” or “I don’t know”.

The highest support was in response to Statement 6: The Chair is supportive of my research, teaching and clinical activities and is responsive to my concerns. Close to 87% agreed or strongly agreed with this statement. One person commented that “this Chair was the first one to actually be interested in my work”.

City-wide joint educational activities (Statement 7) are considered worthwhile and enjoyable. A recurring theme was the challenges for people not in the downtown core. This was particularly dominant with this question.

The last question was an open ended question: “My concerns about the department are:” Three themes were prominent. 1. Inter-hospital relations. Comments noted “competition between the three major teaching sites is not necessarily good for the department “, and “Some sites have a nice working relationship, but some are not as good at team-playing.” There was also concern about the risk of “promotion of a single site over others”. Finally, one person worried about the lack of strength of the university compared to the hospital departments Cyclical Review Fall 2012 Self-Study 67

2. The needs of the community hospitals. Comments noted an “As yet poorly elucidated vision for teaching in the community”; another suggestion was that the Chair should make more visits to the peripheral sites. 3. The needs of new faculty. This was expressed in term of mentorship, and clarity of expectations. It was also apparent from the responses to questions around communication. Part of the confusion was again the role of the University Department compared to the Hospital department.

Summary of Faculty Survey

Although this survey is not exhaustive, it was able to address several key aspects of the Department with a significant sample size. There was a particularly strong response from recent appointees from community sites. Many of their concerns were about integration. Overall, the morale in the department and the support for the Chair is very high. There is a strong sense of pride and community. Longstanding issues about the role of the hospital vs. the university appear to have abated somewhat. Communication within a large group, now also separated by large distances, continues to be a challenge.

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Cyclical Review Fall 2012 Self-Study 69

11.1 Learners’ Report: Undergraduate Students Lesley Hawkins, Mathew Leonardi, Uthra Mohan

Training in Obstetrics and Gynaecology at the undergraduate medical level at the University of Toronto has been well-received and enjoyed by students at the clerkship and pre-clerkship levels.

Our first exposure to the field begins in our second year during the Mechanisms, Manifestations and Management of Diseases course, where we spend several weeks exploring physiology, pathology and disease management through didactic and seminar learning related to women of reproductive age and peri/post-menopausal women. Our evolving curriculum also includes seminars on Ethics in Obs/Gyn as well as LGBTQ health, so as to better serve the diverse patient population we meet in our third year.

However, certain gaps in curriculum have been repeatedly identified by students. Firstly, the lack of formal pelvic exam training in the pre-clerkship years is a common concern for students because they feel unprepared for patient encounters in clerkship. While pelvic exam teaching is indeed taught in both the family medicine and Ob/Gyn rotations in third year (with plastic models), students who have their emergency medicine rotation preceding these do not receive formal training and, thus, feel unprepared for this sensitive exam manoeuvre.

Second, there is a notable absence of training in pregnancy options. Students are interested in learning more in this area to further understand the issues and be prepared for educational or clinical experiences. As it stands currently, interested students can find avenues to enhance their knowledge in these areas (student groups discussed below). However, these areas of obstetrics and gynaecology are not only relevant for those pursuing the specialty; all graduating medical students should receive formal pelvic exam training in a timely manner to prepare them for all clinical experiences and should be knowledgeable with respect to pregnancy options and how patients can receive appropriate care, if necessary.

The third year clerkship curriculum consists of a well-structured 6-week curriculum where students rotate through downtown and community hospitals in the GTA, including: St. Michael’s Hospital, Mount Sinai Hospital, Sunnybrook Hospital, North York General Hospital, St. Joseph’s Hospital, Credit Valley Hospital and Toronto East General Hospital. Many of these hospitals boast world-class facilities and the ability to work with a multidisciplinary team (including Family Medicine Obstetrics and Midwifery). Students gain practical experience in inpatient obstetrics (labour and delivery, maternal fetal medicine) and gynaecology, including normal gynaecologic surgical care, but also fantastic subspecialty gynaecological oncology, reproductive endocrinology and fertility, and urogynaecology.

The core rotation also includes call service and ambulatory (day surgery, emergency and clinics) obstetrics and gynaecology. Many hospitals also have a mentor or preceptor program, which pairs up a student with a staff member who is able foster a period of mentorship and provide guidance during the student’s rotation.

The clerkship curriculum is enriched by daily interactive seminars, unique to the Obstetrics and Gynaecology rotation, where students are taught in small groups in their respective hospitals. Cyclical Review Fall 2012 Self-Study 70

This helps students develop an approach to the broad range of symptoms and diseases, as well as to enhance critical thinking.

A strong majority of students (70-75%) agreed or strongly agreed that the Obstetrics and Gynecology rotation was well organized and had adequate faculty and resident teaching (both clinical and didactic). Along the same lines, a majority of students felt that the quality of lectures and seminars was adequate (80%). Students also have the opportunity to attend hospital-based weekly rounds, subspecialty rounds and journal club.

In addition to formal teaching, students get much informal and bedside teaching from residents, staff physicians and multidisciplinary staff. 67% of students agreed or strongly agreed that the Obstetrics/Gynecology rotation had an appropriate amount of time for self-study, academic teaching, and clinical duties. Although this number is not in and of itself indicative of a weakness, it (along with the surgical rotations) is significantly lower than the other rotations. Moreover, a substantial portion (15%) of students reported spending more than 9 hours in the hospital per day.

A majority of students reported that call expectations were reasonable and adequately supervised. As the primary objective of this rotation is learning, it is recommended that the obstetrics and gynaecology program evaluate ways to maximize student learning without requiring the commitment of too many hours of hospital service. As well, learner competition and overcrowding have been identified as needing improvement with respect to obstetrics and gynaecology. Though new learning sites have been added in 2011-2012, this area of concern should be monitored closely to ensure the issue is resolved.

In addition to formal teaching through lectures and through the rotation, many undergraduate medical students are actively involved in furthering their interest in the specialty through research activities, observerships, electives and selectives and student interest groups.

Students have pursued research in Obstetrics and Gynaecology through the Comprehensive Research Experience for Medical Students (CREMS) program, the CREMS Scholar program, the Determinants of Community Health Course and the MAA-CREMS International Health Summer Research Program. Students have showcased their work in multiple forums such as the Faculty of Medicine’s Medical Student Research Day and at national and international conferences.

The Department of Obstetrics and Gynaecology has unique opportunities in international Women’s Health with ties to Kenya and Zimbabwe, which provide research and practical experiences for many undergraduate students.

In addition to the multitude of research opportunities, many students arrange informal observerships as well as formal elective and selective experiences. Students have also shown much leadership in organizing student interest groups/programs such as the Women’s Health Elective, Medical Students for Choice, Ob/Gyn Student Interest Group, and the Ob/Gyn Mentorship Program. Faculty support for these programs is excellent.

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Two challenges moving forward will be to accommodate the growing student body size and integrating the new Mississauga Academy of Medicine (MAM). The Department of Obstetrics and Gynaecology has fostered ties with other tertiary and quaternary hospitals to accommodate more learners in clerkship as well as pre-clerkship. With the Trillium Health Centre (consisting of Trillium Mississauga Site and Credit Valley Hospital Site) now participating in medical education through the MAM, the thought is that more learners can be accommodated, alleviating some of the overcrowding in the downtown hospitals, as well as exposing students to community obs/gyn. Facilities such as video conferencing and small group seminars are now in place at the Mississauga Academy that run concurrently with the St. George Campus.

However, faculty training and development at the new teaching sites will require keen attention. As well, close monitoring of student experience is expected. Thus far, it is difficult to assess student feedback from the students in Mississauga based on limited time at these sites as of yet.

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Cyclical Review Fall 2012 Self-Study 73

11.2 Learners’ Report -- Residents

This Learners’ Report regarding strengths, weaknesses, and improvements for the residency program reflects information from the a) Annual resident retreat (March 2012) where residents have an opportunity to review the residency program without faculty present and b) residents’ response to a survey (June 2012) asking about the strengths and weaknesses of the program.

1. Strengths: The identified strengths are the:  Volume and variety of both obstetrical and gynaecological cases  Excellent exposure to all subspecialty programs  Proactive resident wellness program.  Anatomy cadaver dissection course.  CIP available for interested residents.  Supportive and knowledgeable staff  Collegial working and learning environment

2. Weaknesses:  Weaknesses expressed related to the academic half-day (AHD) quality and duration have been addressed by a) initiating a new curriculum in September with topics based on resident input and core topics identified in the Royal College requirements, b) extending the AHD to 3 hours and c) including travel time to the teaching site in the protected time.  Finding a research supervisor and topic was a challenge -- This has been addressed in providing the teaching session, “An Introduction to Research” as part of Boot Camp (introductory transition series for the PGY1s and 2s).  PGY1 hands-on experience in the general surgery rotation.

3. Improvements: Many of the recommendations for program improvements regarding the curriculum have been addressed. These include a new curriculum that covers both obstetrics and gynaecology topics equally, clearly defined protected time, more surgical skills labs, and access to simulation programs.

To address our (the residents’) request for attending to our reported disruptive behaviour of a faculty member, the department has instituted alert notifications on POWER relating to Teacher Effectiveness Scores less than 3, so that negative/disruptive behaviour can be identified and brought to the attention of the faculty member in question by the Department Chair, site Chief, the Residency Program Director, or the Wellness Team.

PGY1 Rebecca Rich PGY2 Amanda Cipolla PGY3 Laura Sovran PGY4 Shannon Moore

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Cyclical Review Fall 2012 Self-Study 75

12. Future Directions Dr. Alan Bocking

This self-study has attempted to document the strengths and weaknesses of the Department of Obstetrics and Gynaecology as of September, 2012. As identified, the Department has many strengths in Research and Clinical Care, as well as Undergraduate and Postgraduate Medical Education. The Department has begun a journey of enhancing its profile in Women’s Global Health, as well as developing new socially-responsible programs to improve the care for women in marginalized populations. The Department has been true to its Strategic Plan, as created in 2009, and there is much more that can be done for each of the Strategic Directions. The change in leadership within the Department also will provide an opportunity for the new Chair and Department members to create a new Strategic Plan or, alternatively, build on the existing framework, in conjunction with the Faculty of Medicine Strategic Academic Plan, 2011-2016.

Within the domain of Faculty Development, it is evident that the Department can do more in the areas of Mentorship and Orientation of new Faculty, as well as leadership development, with a view to creating a more robust succession plan for the various leadership positions in the Department. The Department has created a new Mentorship Advisory Committee consisting of Dr. Jennifer Blake, Dr. Heather Shapiro and Dr. Janet Bodley, which will report back to the Executive in the fall. The work of this Committee will be aligned with that of the Faculty of Medicine Task Force and the Centre for Faculty Development.

Dr. Filomena Meffe has eloquently outlined the opportunities for improvement within the Undergraduate Medical Education program and this will include a significant component of Faculty development. We await the recommendations from the Accreditation Committee for the Faculty of Medicine and will respond to any concerns specific to Obstetrics and Gynaecology. The Undergraduate Medical Students have also identified areas for improvement in their report that are currently being addressed by both the University Department Executive and Undergraduate Education Committees. These concerns include learner crowding, timing of pelvic exam teaching, training in pregnancy options, bedside teaching and time spent on duty during Clerkship rotations. Dr. Meffe has indicated her wish to step down from her role as Program Director of Undergraduate Education and a search process has begun for this important position.

The Department has undertaken a number of new initiatives, including the revamping of the Academic Half-Day Curriculum and establishment of the Resident Wellness Program, both of which have been very well received and will be continued.

The Royal College Postgraduate Programs are currently preparing the Pre-survey Questionnaire documents in preparation for the on-site survey to be held in April, 2013. The next Chair, in conjunction with Dr. Heather Shapiro, Vice-Chair, Education and the Program Directors, will be well positioned to respond to the recommendations from the reviewers. Currently, there are 57 Clinical Fellows registered in 15 different programs. Many of these programs are Hospital or Institution-based and it will be critical for the Department, under the leadership of the Vice- Chair, Education, to maintain the high standards of curriculum, evaluation and reporting. Cyclical Review Fall 2012 Self-Study 76

Members of the Division of Urogynaecology and Pelvic Floor Disorders are working actively with their colleagues across the country to prepare a proposal to the Royal College for Diploma status in this subspecialty.

As discussed in the Chair’s Report and the research report of Dr. Stephen Lye, the establishment of the Fraser Mustard Institute of Human Development provides a tremendous opportunity for the Department of Obstetrics and Gynaecology, in collaboration and partnership with other Departments and Faculties in the University, to make an internationally-recognized contribution to this emerging field. The Department must continue to have excellent working relationships with the affiliated hospitals and research institutes and be nimble in order to respond to emerging themes and issues in women’s reproductive health. The Department will need to identify leaders who wish to take on the Chief’s roles at Sunnybrook Health Sciences Centre and Mount Sinai Hospital, which are currently being ably led in an interim nature by Drs. Zaltz and Sermer respectively. In addition, a search will need to begin in 2013 for a new Chief at St. Michael’s Hospital when Dr. Lefebvre steps down from that role to take on greater responsibilities with her Endowed Chair in Women’s Health. The Department will also be looking to identify a new Head of the Division of Urogynaecology and Pelvic Floor Disorders, as Dr. Harold Drutz has indicated his wish to step down from this position.

The Department has established itself as the lead department in reproductive health within the AMPATH Consortium and this opportunity is waiting to be further developed. Stable funding for Global Health Chairs and Fellowships are required, as well as stable core funding for the program, and these are all approved priorities for the Department within the Faculty of Medicine Boundless Campaign. This will be a major focus of the current Chair over the next 10 months and, I hope, will continue to be a priority for the Department.

As in any large, multi-sited organization, communication is critical and the Department relies heavily on e-mail from 92 College, the Department’s office. In addition, we distribute a Newsletter twice yearly. Department leadership could undergo a “needs assessment” of Faculty members regarding the type and timeliness of communication they would like to receive, given the significant increase in Community-affiliate Hospital-based Faculty.

The Department also has the opportunity to create, within Divisions, standardized Clinical Care Protocols using the best available evidence that can be used to help inform policy and procedures at the hospital, LHIN and provincial levels.

13. FACULTY CV LIST PRIMARY FACULTY Last Name First Name Adamson S Lee Aggarwal Anjali Alarab May Allen Lisa Arthur Rebecca Bambao Clarissa Barkin Marshall Barrett Jon Bentov Yaakov Berger Howard Bernardini Marcus Bernstein Paul Blake Jennifer Bocking Alan Bodley Janet Brown Theodore J Caniggia Isabella Casper Robert Chang Paul Cheng Mary Covens Al Cruickshank Barbara Dong Xuesen Doyle Patricia Drutz Harold Farine Dan Farrugia Michele Ferguson Sarah Freire-Lizama Tatiana Gien Lilian Greenblatt Ellen Herer Elaine Ho Man Fan Jurisicova Andrea Kingdom John Kirkham Yolanda Kives Sari Kroft Jamie Laframboise Stephane Lausman Andrea Lefebvre Guylaine Liu Kimberly Lovatsis Danny Lye Stephen Malinowski Ann Maxwell Cindy McDermott Colleen Moskovtsev Sergey Murphy Joan Murphy Kellie Myckan Kerry Nevo Ori Okun Nan Ornstein Melanie Osborne Ray Pairaudeau Nicholas Phillips Perry Pittini Richard Rogers Ian Rosen Barry Roth Nathan Ryan Greg Seaward Gareth Selk Amanda Sermer Mathew Shapiro Heather Sharma Pratibhasri Shier Michael Silver Michael Spitzer Rachel Tessler Karen Tunde-Byass Modupe Watt Peter Windrim Rory Wolfman Wendy Woods Brenda Yudin Mark CROSS-APPOINTED FACULTY Last Name First Name Asztalos Elizabeth Belsham Denise Carvalho Jose Chitayat David Chong Karen Colgan Terence Colman Jack Dunn Michael Feig Denice Fyles Anthony Hannah Mary E. Keating Sarah Khalifa Mahmoud Letarte Michelle Matthews Stephen Narod Steven Oza Amit Rossant Janet Thomas Gillian Toi Ants ADJUNCT FACULTY Last Name First Name Esfandiari Navid Singh Gita Thistle Paul

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