Communications in Computer and Information Science 1024

Commenced Publication in 2007 Founding and Former Series Editors: Phoebe Chen, Alfredo Cuzzocrea, Xiaoyong Du, Orhun Kara, Ting Liu, Krishna M. Sivalingam, Dominik Ślęzak, Takashi Washio, and Xiaokang Yang

Editorial Board Members Simone Diniz Junqueira Barbosa Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brazil Joaquim Filipe Polytechnic Institute of Setúbal, Setúbal, Portugal Ashish Ghosh Indian Statistical Institute, Kolkata, India Igor Kotenko St. Petersburg Institute for Informatics and Automation of the Russian Academy of Sciences, St. Petersburg, Russia Junsong Yuan University at Buffalo, The State University of New York, Buffalo, NY, USA Lizhu Zhou Tsinghua University, Beijing, China More information about this series at http://www.springer.com/series/7899 Alberto Cliquet Jr. • Sheldon Wiebe • Paul Anderson • Giovanni Saggio • Reyer Zwiggelaar • Hugo Gamboa • Ana Fred • Sergi Bermúdez i Badia (Eds.)

Biomedical Engineering Systems and Technologies 11th International Joint Conference, BIOSTEC 2018 Funchal, Madeira, Portugal, January 19–21, 2018 Revised Selected Papers

123 Editors Alberto Cliquet Jr. Sheldon Wiebe University of Sao Paulo University of Saskatchewan São Paulo, Brazil Saskatoon, Canada Paul Anderson Giovanni Saggio College of Charleston University of Rome Tor Vergata Charleston, SC, USA Rome, Italy Reyer Zwiggelaar Hugo Gamboa Aberystwyth University LIBPhys Aberystwyth, UK New University of Lisbon Lisbon, Portugal Ana Fred Instituto de Telecomunicações Sergi Bermúdez i Badia and Instituto Superior Técnico Madeira Interactive Technologies Institute Lisbon, Portugal Universidade da Madeira Funchal, Portugal

ISSN 1865-0929 ISSN 1865-0937 (electronic) Communications in Computer and Information Science ISBN 978-3-030-29195-2 ISBN 978-3-030-29196-9 (eBook) https://doi.org/10.1007/978-3-030-29196-9

© Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface

The present book includes extended and revised versions of a set of selected papers from the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018), held in Funchal, Madeira, Portugal, during January 19–21, 2018. BIOSTEC is composed of five co-located conferences, each specialized in a different knowledge area, namely, BIODE-VICES, BIOIMAGING, BIOINFORMATICS, BIOSIGNALS, and HEALTH-INF. BIOSTEC 2018 received 344 paper submissions from 50 countries, of which only 7% are included in this book. This reflects our care in selecting those contributions. These papers were selected by the conference chairs and their selection is based on a number of criteria that include the classifications and comments provided by the Program Committee members, the session chairs’ assessment, and the program chairs’ meta review of the papers that were included in the technical program. The authors of selected papers were invited to submit a revised, extended, and improved version of their conference paper, including at least 30% new material. The purpose of the BIOSTEC joint conferences is to bring together researchers and practitioners, including engineers, biologists, health professionals, and informatics/ computer scientists. Research presented at BIOSTEC included both theoretical advances and applications of information systems, artificial intelligence, signal processing, electronics, and other engineering tools in areas related to advancing biomedical research and improving healthcare. These advances and improvements are to answer modern requests relevant in the medical field that have not been evolving as rapidly as in other fields. Different examples can be made: aviation evolved from the first flight of the Wright brothers in 1903 to the current tests for commercial space flights; the automotive evolved from the first model-T by Ford in 1908 to the current electric motor Model 3 by Tesla; radio-communications evolved from the bulky radio stations by Marconi company in 1897 to the current foldable smartphone models Mate X and Galaxy X by Huawei and Samsung, respectively. Conversely, the hospital model is pretty similar today as it was in the seventeenth century: rooms with beds where patients are lying down and medical doctors come to visit. Fortunately, new technologies are continuously evolving, allowing medical doctors to count on new and more objective measures of biomarkers for different pathologies (objectively-based rather than subjectively-based diagnostics), medical treatments that are considerable more focused on the individual rather than the pathology (personalized medicine), and new wearable technology for non-invasive measures to allow for telemedicine, without forcing the patient to go every-time to the hospital (home-care treatment). Within Medical Imaging, there is a continued rapid development in using large datasets and high computational processes in data analysis and evaluation. Artificial Intelligence interests have increased significantly to the point where large multinational companies are significantly investing in developing products that could potentially vi Preface automate some of the work done at clinical level. I think in the future there will be two major disruptive scientific developments within the world of Medical Imaging. One, mentioned above, is the use of artificial intelligence in medical imaging systems. The other is the integration of targeted contrast or therapeutic agents that will provide some functional imaging or therapeutic component to anatomical imaging and may be very disease specific. Within this framework, this book includes different, meaningful contributions, from new technologies for objective measurements, to new algorithms to manage medical records, to predictive algorithms, and so forth. We would like to thank all the authors for their contributions and also to the reviewers who have helped to ensure the quality of this publication.

January 2018 Alberto Cliquet Jr. Sheldon Wiebe Paul Anderson Giovanni Saggio Reyer Zwiggelaar Hugo Gamboa Ana Fred Sergi Bermúdez i Badia Organization

Conference Co-chairs

Hugo Gamboa LIBPHYS-UNL/FCT, New University of Lisbon, Portugal Ana Fred Instituto de Telecomunicaçöes/IST, Lisbon University, Portugal Sergi Bermúdez i Badia Madeira Interactive Technologies Institute, Universidade da Madeira, Portugal

Program Co-chairs BIODEVICES Alberto Cliquet Jr. University of Säo Paulo and University of Campinas, Brazil

BIOIMAGING Sheldon Wiebe University of Saskatchewan, Canada

BIOINFORMATICS Paul Anderson College of Charleston, USA

BIOSIGNALS Giovanni Saggio University of Rome Tor Vergata, Italy

HEALTHINF Reyer Zwiggelaar Aberystwyth University, UK

BIODEVICES Program Committee Nizametin Aydin Yildiz Technical University, Turkey Steve Beeby University of Southampton, UK Dinesh Bhatia North Eastern Hill University, India Luciano Boquete Alcala University, Spain Jan Cabri Norwegian School of Sport Sciences, Norway Carlo Capelli Norwegian School of Sport Sciences, Norway Youngjae Chun University of Pittsburgh, USA Alberto Cliquet Jr. University of Säo Paulo and University of Campinas, Brazil Albert Cook Faculty of Rehabilitation Medicine, University of Alberta, Canada viii Organization

George Dulikravich Florida International University, USA Maria Evelina Fantacci University of Pisa, INFN, Italy Elisabetta Farella Fondazione Bruno Kessler, Italy Mireya Fernández Chimeno Universitat Politècnica de Catalunya, Spain Bruno Gago University of Aveiro, Portugal Juan Carlos Garcia University of Alcala, Spain Miguel García Gonzalez Universitat Politècnica de Catalunya, Spain Javier Garcia-Casado Universitat Politècnica de València, Spain Michinao Hashimoto Singapore University of Technology and Design, Singapore Leonid Hrebien Drexel University, USA Sandeep Jha Indian Institute of Technology Delhi, India Kourosh Kalantar-Zadeh University of New South Wales, Australia Bozena Kaminska Simon Fraser University, Canada Eyal Katz Afeka Tel Aviv Academic College of Engineering, Israel Michael Kraft University of Liege, Belgium Ondrej Krejcar University of Hradec Kralove, Czech Republic Vladimir Kublanov Ural Federal University, Russia Jung Lee Seoul National University, South Korea Anita Lloyd Spetz Linköpings Universitet, Sweden Mai Mabrouk Misr University for Science and Technology, Egypt Carlos Maciel University of Säo Paulo, Brazil Jordi Madrenas Universitat Politècnica de Catalunya, Spain Jarmo Malinen Aalto University, Finland Dan Mandru Technical University of Cluj Napoca, Romania Joseph Mizrahi Technion - Israel Institute of Technology, Israel Ana Moita IN+, Instituto Superior Técnico, Portugal Raimes Moraes Universidade Federal de Santa Catarina, Brazil Umberto Morbiducci Politecnico di Torino, Italy Antoni Nowakowski Gdansk University of Technology, Poland Eoin O’Cearbhaill University College Dublin, Ireland Abraham Otero Universidad San Pablo CEU, Spain Gonzalo Pajares Universidad Complutense de Madrid, Spain Krzysztof Pancerz University of Rzeszow, Poland Sofia Panteliou University of Patras, Greece Lionel Pazart Tech4Health/F-CRIN, Inserm, CHU de Besançon, France Marek Penhaker VŠB - Technical University of Ostrava, Czech Republic Shubhajit Roy Chowdhury Indian Institute of Technology Mandi, India Wim Rutten University of Twente, The Netherlands Seonghan Ryu Hannam University, South Korea Jose M. Sabater Miguel Hernandez University, Spain Michael Schöning FH Aachen, Germany Mauro Serpelloni University of Brescia, Italy Organization ix

Dong Ik Shin Asan Medical Center, South Korea Filomena Soares Algoritmi Research Centre, UM, Portugal Akihiro Takeuchi Kitasato University School of Medicine, Japan Marco Tatullo Tecnologica Research Institute, Italy John Tudor University of Southampton, UK Egon L. van den Broek Utrecht University, The Netherlands Renato Varoto University of Campinas, Brazil Pedro Vieira Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal Bruno Wacogne FEMTO-ST, UMR CNRS 6174, France Hakan Yavuz Çukurova Üniversity, Turkey Alberto Yufera Instituto de MIcroelectronica de Sevilla, Universidad de Sevilla, Spain Xian-En Zhang Institute of Biophysics, Chinese Academy of Sciences, China

BIOIMAGING Program Committee Anna Chiara De Luca IBP-CNR, Italy Sameer Antani National Library of Medicine, National Institutes of Health, USA Peter Balazs University of Szeged, Hungary Grégory Barbillon EPF Ecole d’Ingénieurs, France Richard Bayford Middlesex University, UK Alpan Bek Middle East Technical University, Turkey Obara Boguslaw University of Durham, UK Alexander Bykov University of Oulu, Optoelectronics and Measurement Techniques Laboratory, Finland Enrico Caiani Politecnico di Milano, Italy Begoña Calvo University of Zaragoza, Spain Alessia Cedola CNR, Institute of Nanotechnology, Italy Heang-Ping Chan University of Michigan, USA Chung-Ming Chen National Taiwan University, Taiwan Guanying Chen Harbin Institute of Technology and SUNY Buffalo, China Miguel Coimbra IT, University of Porto, Portugal Giacomo Cuttone INFN, Laboratori Nazionali del Sud Catania, Italy Alexandre Douplik Ryerson University, Canada Wolfgang Drexler Medical University Vienna, Austria Karen Drukker The University of Chicago, USA Edite Figueiras Champalimaud Foundation, Portugal Costel Flueraru National Research Council of Canada, Canada Dimitrios Fotiadis University of Ioannina, Greece Carlos Geraldes Universidade de Coimbra, Portugal P. Gopinath Indian Institute of Technology Roorkee, India Dimitris Gorpas Technical University of Munich, Germany x Organization

Patricia Haro Gonzalez Fluorescent Imaging Group, Universidad Autonoma Madrid, Spain Tzung-Pei Hong National University of Kaohsiung, Taiwan Ying Hu Salk Institute, Nomis Center for Immunobiology and Microbial Pathogenesis, USA Jae Youn Hwang DGIST, South Korea Rittscher Jens University of Oxford, UK Ming Jiang Peking University, China Xiaoyi Jiang University of Münster, Germany Pluim Josien Eindhoven University of Technology, The Netherlands Jan Kalina Institute of Computer Science CAS, Czech Republic Sinan Kockara University of Central Arkansas, USA Algimantas Krisciukaitis Lithuanian University of Health Sciences, Lithuania Adriaan Lammertsma VU University Medical Center Amsterdam, The Netherlands Sang-Won Lee Korea Research Institute of Standards and Science, South Korea Ivan Lima Jr. North Dakota State University, USA Benoit Macq UCLouvain, Belgium Jan Mares University of Chemistry and Technology, Czech Republic Pavel Matula Faculty of Informatics, Masaryk University, Czech Republic Aidan Meade Centre for Radiation and Environmental Science, Dublin Institute of Technology, Ireland Israel Mendoza Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Mexico Kunal Mitra Florida Institute of Technology, USA Christophoros Nikou University of Ioannina, Greece Joanna Isabelle Olszewska University of West Scotland, UK Kalman Palagyi University of Szeged, Hungary George Panoutsos The University of Sheffield, UK Gennaro Percannella University of Salerno, Italy Laurent Pilon UCLA, USA Ales Prochazka University of Chemistry and Technology, Czech Republic Wan Qin University of Washington, USA Anthi Ranella Foundation for Research and Technology-Hellas (FORTH), Greece Alessandra Retico Istituto Nazionale di Fisica Nucleare, Italy Giovanna Rizzo Consiglio Nazionale delle Ricerche, Italy Bart Romeny Eindhoven University of Technology (TU/e), The Netherlands Olivier Salvado CSIRO, Australia Carlo Sansone University of Naples Federico II, Italy K. C. Santosh The University of South Dakota, USA Organization xi

Jan Schier The Institute of Information Theory and Automation of the Czech Academy of Sciences, Czech Republic Gregory Sharp Massachusetts General Hospital, USA Leonid Shvartsman Hebrew University, Israel Arcot Sowmya UNSW, Australia Chi-Kuang Sun National Taiwan University, Taiwan Piotr Szczepaniak Institute of Information Technology, Lodz University of Technology, Poland Pablo Taboada University of Santiago de Compostela, Spain Jie Tian Chinese Academy of Sciences, China Arkadiusz Tomczyk Institute of Information Technology, Lodz University of Technology, Poland Ibtisam Tothill Cranfield University, UK Muhammed Toy Istanbul Medipol University, Turkey Carlos M. Travieso University of Las Palmas de Gran Canaria, Spain Benjamin Tsui Johns Hopkins University, USA Vladimír Ulman Faculty of Informatics, Masaryk University, Czech Republic Sandra Ventura School of Health - Escola Superior de Saüde do Politécnico do Porto, Portugal Vijay Vijay Massachusetts Institute of Technology, USA Irina Voiculescu University of Oxford, UK Yuanyuan Wang Fudan University, China Quan Wen University of Electronic Science and Technology of China, China Sheldon Wiebe University of Saskatchewan, Canada Lei Xi University of Electronic Science and Technology of China, China Hongki Yoo Hanyang University, South Korea Zeyun Yu University of Wisconsin at Milwaukee, USA Jiangbo Zhao University of Adelaide, Australia

BIOIMAGING Additional Reviewers Xiaoli Qi Johns Hopkins University, USA

BIOINFORMATICS Program Committee Allen Adum Nnamdi Azikiwe University, Nigeria Afiahayati Afiahayati Universitas Gadjah Mada, Indonesia Tatsuya Akutsu Kyoto University, Japan Jens Allmer Hochschule Ruhr West, University of Applied Sciences, Germany Paul Anderson College of Charleston, USA Francois Andry Philips, France Sameer Antani National Library of Medicine, National Institutes of Health, USA xii Organization

Marco Antoniotti Università degli Studi di Milano Bicocca, Italy Joel Arrais Universidade de Coimbra, Portugal Lucia Ballerini University of Edinburgh, UK Emiliano Universidad Nacional de Colombia, Colombia Barreto-Hernandez Dhundy Bastola University of Nebraska at Omaha, USA Payam Behzadi Shahr-e-Qods Branch, Islamic Azad University, Iran Shifra Ben-Dor Weizmann Institute of Science, Israel Michael Biehl University of Groningen, The Netherlands Ugur Bilge Akdeniz University, Turkey Judith Blake Jackson Laboratory, USA Leonardo Bocchi Università di Firenze, Italy Ulrich Bodenhofer Johannes Kepler University Linz, Austria Luca Bortolussi University of Trieste, Italy Conrad Burden Australian National University, Australia Giulio Caravagna University of Edinburgh, UK José Cerón Carrasco Universidad Católica San Antonio de Murcia, Spain Marcus Cheetham University of Zurich, Switzerland Wai-Ki Ching The University of Hong Kong, SAR China Young-Rae Cho Baylor University, USA Mark Clement Brigham Young University, USA Federica Conte National Research Council of Rome, Italy Kathryn Cooper University of Nebraska at Omaha, USA Antoine Danchin Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, France Thomas Dandekar University of Würzburg, Germany Sérgio Deusdado Instituto Politecnico de Bragança, Portugal Santa Di Cataldo Politecnico di Torino, Italy Richard Edwards University of Southampton, UK Maria Evelina Fantacci University of Pisa, INFN, Italy Fabrizio Ferre University of Rome Tor Vergata, Italy António Ferreira Faculdade de Ciências da Universidade de Lisboa, Portugal Giulia Fiscon National Research Council of Rome (CNR), Italy Liliana Florea Johns Hopkins University, USA Alexandre Francisco Instituto Superior Técnico, Universidade de Lisboa, Portugal Dmitrij Frishman Technical University of Munich, Germany Christopher Hann University of Canterbury, New Zealand Ronaldo Hashimoto University of Säo Paulo, Brazil Shan He University of Birmingham, UK Daniela Iacoviello Sapienza University of Rome, Italy Sohei Ito National Fisheries University, Japan Bo Jin MilliporeSigma, Merck KGaA, USA Giuseppe Jurman Fondazione Bruno Kessler, Italy Organization xiii

Yannis Kalaidzidis Max Planck Institute Molecular Cell Biology and Genetic, Germany Michael Kaufmann Witten/Herdecke University, Germany Natalia Khuri Wake Forest University, USA Inyoung Kim Virginia Tech, USA Jirí Kléma Czech Technical University in Prague, Faculty of Electrical Engineering, Czech Republic Malgorzata Kotulska Wroclaw University of Technology, Poland Ivan Kulakovskiy Russia Carlile Lavor University of Campinas, Brazil Antonios Lontos Frederick University, Cyprus Pawel Mackiewicz Faculty of Biotechnology, Wroclaw University, Poland Paolo Magni Università degli Studi di Pavia, Italy Thérése Malliavin CNRS/Institut Pasteur, France Elena Marchiori Radboud University, The Netherlands Andrea Marin University of Venice, Italy Majid Masso George Mason University, USA Petr Matula Faculty of Informatics, Masaryk University, Czech Republic Giancarlo Mauri Università di Milano Bicocca, Italy Nikolaos Michailidis Aristoteles University of Thessaloniki, Greece Paolo Milazzo Università di Pisa, Italy Pedro Monteiro INESC-ID/IST, Universidade de Lisboa, Portugal Monica Mordonini Universitá Degli Studi Di Parma, Italy Vincent Moulton University of East Anglia, UK Helder Nakaya University of Säo Paulo, Brazil David Naranjo-Hernández University of Seville, Spain Jean-Christophe Nebel Kingston University, UK José Oliveira University of Aveiro, DETI/IEETA, Portugal Hakan Orer Koc University, Turkey Giulia Paciello Politecnico di Torino, Italy Taesung Park Seoul National University, South Korea Oscar Pastor Universidad Politécnica de Valencia, Spain Marco Pellegrini Consiglio Nazionale delle Ricerche, Italy Matteo Pellegrini University of California, Los Angeles, USA Horacio Pérez-Sánchez Catholic University of Murcia, Spain Nadia Pisanti Università di Pisa, Italy Olivier Poch ICube, UMR 7357 CNRS, Université de Strasbourg, France Alberto Policriti Università degli Studi di Udine, Italy Gianfranco Politano Politecnico di Torino, Italy Giuseppe Profiti University of Bologna, Italy Maria Psiha Ionian University, Greece Junfeng Qu Clayton State University, USA Javier Reina-Tosina University of Seville, Spain Laura Roa University of Seville, Spain xiv Organization

Simona Rombo Dipartimento di Matematica e Informatica, Università degli Studi di Palermo, Italy Eric Rouchka University of Louisville, USA Claudia Rubiano Universidad Nacional de Colombia, Colombia Castellanos Carolina Ruiz WPI, USA J. Salgado University of Chile, Chile Alessandro Savino Politecnico di Torino, Italy Noor Akhmad Setiawan Universitas Gadjah Mada, Indonesia João Setubal Universidade de São Paulo, Brazil Christine Sinoquet University of Nantes, France Neil Smalheiser University of Illinois Chicago, USA Pavel Smrz Brno University of Technology, Czech Republic Gordon Smyth Walter and Eliza Hall Institute of Medical Research, Australia Yinglei Song Jiansu University of Science and Technology, China David Svoboda Masaryk University, Czech Republic Peter Sykacek University of Natural Resources and Life Sciences, Austria Gerhard Thallinger Graz University of Technology, Austria Takashi Tomita Japan Advanced Institute of Science and Technology, Japan Alexander Tsouknidas Aristotle University of Thessaloniki, Greece Gabriel Valiente Technical University of Catalonia, Spain Juris Viksna Institute of Mathematics and Computer Science, University of Latvia, Latvia Arndt von Haeseler Center for Integrative Bioinformatics Vienna, Austria Sebastian Will Universität Leipzig, Germany Yanbin Yin University of Nebraska, USA Malik Yousef Zefat Academic College, Israel Erliang Zeng University of Iowa, USA Wen Zhang Icahn School of Medicine at Mount Sinai, USA Leming Zhou University of Pittsburgh, USA Jiali Zhuang Molecular Stethoscope Inc., USA

BIOINFORMATICS Additional Reviewers Artem Kasianov VIGG, Russia Michalis Michaelides The University of Edinburgh, UK Cátia Vaz INESC-ID, Portugal

BIOSIGNALS Program Committee Bruce Denby Université Pierre et Marie Curie, France Robert Allen University of Southampton, UK Alexandre Andrade Faculdade de Ciências da Universidade de Lisboa, Portugal Organization xv

Mochammad Ariyanto Diponegoro University, Indonesia Sridhar Arjunan RMIT University, Australia Joonbum Bae UNIST, South Korea Richard Bayford Middlesex University, UK Eberhard Beck Brandenburg University of Applied Sciences, Germany Philipp Beckerle TU Darmstadt, Germany Peter Bentley UCL, UK Santosh Bothe NMIMS Deemed to be University, India Bethany Bracken Charles River Analytics Inc., USA Maurizio Caon University of Applied Sciences and Arts Western Switzerland, Switzerland Guy Carrault University of Rennes 1, France Maria Claudia Castro Centro Universitário FEI, Brazil Marcus Cheetham University of Zurich, Switzerland Gaurav Chitranshi HCL Technologies Ltd., Technical Excellence Group, Uttar Pradesh, India Bruno Cornelis Vrije Universiteit Brussel (VUB), Belgium Jan Cornelis VUB, Belgium Adam Czajka University of Notre Dame, USA Christakis Damianou Cyprus University of Technology, Cyprus Justin Dauwels Nanyang Technological University, Singapore Gert-Jan de Vries Philips Research - Healthcare, The Netherlands Petr Dolezel University of Pardubice, Czech Republic Pier Emiliani Italian National Research Council (CNR), Italy Pedro Encarnaçäo Universidade Católica Portuguesa, Portugal Poree Fabienne Université de Rennes 1, France Luca Faes Università degli Studi di Trento, Italy Dimitrios Fotiadis University of Ioannina, Greece Takuya Funatomi Nara Institute of Science and Technology, Japan Javier Garcia-Casado Universitat Politècnica de València, Spain Arfan Ghani Coventry University, UK James Gilbert University of Hull, UK Didem Gokcay Middle East Technical University, Turkey Pedro Gómez Vilda Universidad Politécnica de Madrid, Spain Inan Güler Gazi University, Turkey Thomas Hinze Friedrich Schiller University Jena, Germany Roberto Hornero University of Valladolid, Spain Donna Hudson University of California San Francisco, USA Bart Jansen Vrije Universiteit Brussel, Belgium Gordana Jovanovic Dolecek Institute INAOE, Mexico Tzyy-Ping Jung University of California San Diego, USA Natalya Kizilova Warsaw University of Technology, Poland Dagmar Krefting HTW Berlin - University of Applied Sciences, Germany Vaclav Kremen Czech Technical University in Prague, Czech Republic Lenka Lhotska Czech Technical University in Prague, Czech Republic xvi Organization

Julián Londoño Universidad de Antioquia, Colombia Ana Londral Universidade de Lisboa, Portugal Harald Loose Brandenburg University of Applied Sciences, Germany S. Maheswaran Department of ECE, Kongu Engineering College, India Jan Mares University of Chemistry and Technology, Czech Republic Pina Marziliano Nanyang Technological University, Singapore Pramod Meher Singapore Jirí Mekyska Brno University of Technology, Czech Republic Vojkan Mihajlovic Holst Centre, imec the Netherlands, The Netherlands Mihaela Morega University Politehnica of Bucharest, Romania Minoru Nakayama Tokyo Institute of Technology, Japan Percy Nohama Pontifícia Universidade Católica do Paraná, Brazil Giandomenico Nollo Università degli Studi di Trento, Italy Joanna Isabelle Olszewska University of West Scotland, UK Andres Orozco-Duque Instituto Tecnológico Metropolitano, Colombia Rui Pedro Paiva University of Coimbra, Portugal Krzysztof Pancerz University of Rzeszow, Poland Gennaro Percannella University of Salerno, Italy Vitor Pires Escola Superior de Tecnologia de Setübal, Instituto Politécnico de Setübal, Portugal Shitala Prasad NTU Singapore, Singapore Ales Prochazka University of Chemistry and Technology, Czech Republic Palaniappan Ramaswamy University of Kent, UK José Joaquín Rieta Universidad Politécnica de Valencia, Spain Marcos Rodrigues Sheffield Hallam University, UK Elmar Rueckert University of Luebeck, Germany Heather Ruskin Dublin City University, Ireland Giovanni Saggio University of Rome Tor Vergata, Italy Andrews Samraj Mahendra Engineering College, India Anita Sant’Anna Halmstad University, Sweden Gerald Schaefer Loughborough University, UK Reinhard Schneider Fachhochschule Vorarlberg, Austria Lotfi Senhadji University of Rennes 1, France Elizabeth Shumbayawonda University of Surrey, UK Samuel Silva Department Electronics Telecommunications & Informatics/IEETA, Universidade de Aveiro, Portugal Jordi Solé-Casals University of Vic - Central University of Catalonia, Spain Alan Stocker University of Pennyslvania, USA Nicola Strisciuglio University of Groningen, The Netherlands António Teixeira University of Aveiro, Portugal João Teixeira Polytechnic Institute of Bragança, Portugal Carlos Thomaz Centro Universitário FEI, Brazil Organization xvii

Ana Tomé University of Aveiro, Portugal Carlos M. Travieso University of Las Palmas de Gran Canaria, Spain Ahsan Ursani Mehran University of Engineering and Technology, Pakistan Pedro Vaz University of Coimbra, Portugal Giovanni Vecchiato National Research Council, Italy Jacques Verly University of Liege, Belgium Yuanyuan Wang Fudan University, China Quan Wen University of Electronic Science and Technology of China, China Didier Wolf Research Centre for Automatic Control, CRAN CNRS UMR 7039, France Chia-Hung Yeh National Sun Yat-sen University, Taiwan Rafal Zdunek Wroclaw University of Technology, Poland Wei Zhang Swiss Federal Institute of Technology Lausanne, Switzerland Aneeq Zia Georgia Institute of Technology, USA

BIOSIGNALS Additional Reviewers Francesco Carrino University of Applied Sciences and Arts Western Switzerland, Switzerland Luca Gerardo Giorda BCAM Basque Center for Applied Mathematics, Spain

HEALTHINF Program Committee Anurag Agrawal CSIR Institute of Genomics and Integrative Biology, Center for Translational Research in Asthma & Lung, India Francois Andry Philips, France Wassim Ayadi LERIA, University of Angers, France and LaTICE, University of Tunis, Tunisia Payam Behzadi Shahr-e-Qods Branch, Islamic Azad University, Iran Bert-Jan van Beijnum University of Twente, The Netherlands Sorana Bolboaca Iuliu Hatieganu University of Medicine and Pharmacy, Romania Alessio Bottrighi Universitá del Piemonte Orientale, Italy Andrew Boyd University of Illinois at Chicago, USA Klaus Brinker Hamm-Lippstadt University of Applied Sciences, Germany Edward Brown Memorial University, Canada Eric Campo LAAS CNRS, France Guilherme Campos IEETA, Portugal Marc Cavazza University of Greenwich, UK Rui César das Neves Directorate-General of Health, Portugal James Cimino School of Medicine at the University of Alabama at Birmingham, USA xviii Organization

Miguel Coimbra IT, University of Porto, Portugal Emmanuel Conchon XLIM, France Carlos Costa Universidade de Aveiro, Portugal Berry de Bruijn National Research Council, Canada Liliana Dobrica University Politehnica of Bucharest, Romania Stephan Dreiseitl Upper Austria University of Applied Sciences at Hagenberg, Austria George Drosatos Democritus University of Thrace, Greece Martin Duneld Stockholm University, Sweden Christo El Morr York University, Canada José Fonseca UNINOVA, Portugal Daniel Ford Dell Research, USA Christoph Friedrich University of Applied Sciences and Arts Dortmund, Germany Ioannis Fudos University of Ioannina, Greece Henry Gabb University of Illinois at Urbana-Champaign, USA James Geller New Jersey Institute of Technology, USA Yves Gourinat ISAE-SUPAERO, France David Greenhalgh University of Strathclyde, UK Tahir Hameed Merrimack College, USA Andrew Hamilton-Wright Mount Allison University, Canada Jorge Henriques Universidade de Coimbra, Portugal Dragan Jankovic Faculty of Electronic Engineering Nis, Serbia Petr Ježek University of West Bohemia, Czech Republic Eleni Kaldoudi Democritus University of Thrace, Greece Jan Kalina Institute of Computer Science CAS, Czech Republic Anne Kanstrup Aalborg University, Denmark Finn Kensing University of Copenhagen, Denmark Panayiotis Ketikidis The International Faculty of the University of Sheffield, CITY College, Greece Tomohiro Kuroda Kyoto University Hospital, Japan Elyes Lamine University of Toulouse, CUFR J.F. Champollion, France Nekane Larburu Rubio Vicomtech, Spain Giuseppe Liotta University of Perugia, Italy Nicolas Loménie Université Paris Descartes, France Guillaume Lopez Aoyama Gakuin University, Japan Martin Lopez-Nores University of Vigo, Spain Alda Marques University of Aveiro, Portugal Paloma Martínez Universidad Carlos III de Madrid, Spain Ken Masters Sultan Qaboos University, Oman James McGlothlin Fusion Consulting Inc., USA Vincenzo Mea University of Udine, Italy Rebecca Meehan Kent State University, USA Roman Moucek University of West Bohemia, Czech Republic Binh Nguyen Victoria University of Wellington, New Zealand Organization xix

José Oliveira University of Aveiro, DETI/IEETA, Portugal Agnieszka Onisko Faculty of Computer Science, Bialystok University of Technology, Poland Thomas Ostermann Witten/Herdecke University, Germany Nelson Pacheco da Rocha University of Aveiro, Portugal Rui Pedro Paiva University of Coimbra, Portugal Sotiris Pavlopoulos ICCS, Greece Alejandro Pazos Sierra University of A Coruña, Spain José Pazos-Arias University of Vigo, Spain Fabrizio Pecoraro National Research Council, Italy Liam Peyton University of Ottawa, Canada Enrico Piras Fondazione Bruno Kessler, Italy Arkalgud Ramaprasad University of Illinois at Chicago, USA Grzegorz Redlarski Gdansk University of Technology, Poland Ita Richardson University of Limerick, Ireland Marcos Rodrigues Sheffield Hallam University, UK Alejandro Rodríguez Centro de Tecnología Biomédica, Spain González Elisabetta Ronchieri INFN, Italy Carolina Ruiz WPI, USA Renato Sabbatini The Edumed Institute, Brazil George Sakellaropoulos University of Patras, Greece Ovidio Salvetti National Research Council of Italy (CNR), Italy Akio Sashima AIST, Japan Bettina Schnor Potsdam University, Germany Yuval Shahar Ben Gurion University, Israel Aziz Sheikh Centre of Medical Informatics, University of Edinburgh, UK Berglind Smaradottir University of Agder, Norway Äsa Smedberg Stockholm University, Sweden Jiangwen Sun Old Dominion University, USA Lauri Tuovinen Dublin City University, Ireland Mohy Uddin King Abdullah International Medical Research Center (KAIMRC), Saudi Arabia Gary Ushaw Newcastle University, UK Aristides Vagelatos CTI, Greece Egon L. van den Broek Utrecht University, The Netherlands Sitalakshmi Venkatraman Melbourne Polytechnic, Australia Francisco Veredas Universidad de Málaga, Spain Dagmar Waltemath University of Rostock, Germany Szymon Wilk Institute of Computing Science, Poznan University of Technology, Poland Janusz Wojtusiak George Mason University, USA Jitao Yang China xx Organization

Lixia Yao Mayo Clinic, USA Xuezhong Zhou Beijing Jiaotong University, China André Züquete IEETA, IT, Universidade de Aveiro, Portugal

HEALTHINF Additional Reviewers Luca Piovesan Università del Piemonte Orientale, Italy

Invited Speakers

Anatole Lécuyer Inria Rennes/IRISA, Hybrid Research Team, France Corina Sas Lancaster University, UK Dinesh Kumar RMIT University, Australia Maximiliano Romero Università Iuav di Venezia, Italy Contents

Biomedical Electronics and Devices

Fiber Bragg Based Sensors for Foot Plantar Pressure Analysis ...... 3 Arnaldo G. Leal-Junior, M. Fátima Domingues, Rui Min, Débora Vilarinho, Antreas Theodosiou, Cátia Tavares, Nélia Alberto, Cátia Leitão, Kyriacos Kalli, Anselmo Frizera-Neto, Paulo André, Paulo Antunes, and Carlos Marques

A New Compact Optical System Proposal and Image Quality Comparison Against Other Affordable Non-mydriatic Fundus Cameras ...... 26 David Melo, Filipe Soares, Simão Felgueiras, João Gonçalves, and Pedro Vieira

Design and Optimization of an Open Configuration Microfluidic Device for Clinical Diagnostics ...... 49 A. S. Moita, F. Jacinto, F. Mata, and A. L. N. Moreira

Bioimaging

Transferability of Deep Learning Algorithms for Malignancy Detection in Confocal Laser Endomicroscopy Images from Different Anatomical Locations of the Upper Gastrointestinal Tract ...... 67 Marc Aubreville, Miguel Goncalves, Christian Knipfer, Nicolai Oetter, Tobias Würfl, Helmut Neumann, Florian Stelzle, Christopher Bohr, and Andreas Maier

Min-Cut Segmentation of Retinal OCT Images ...... 86 Bashir Isa Dodo, Yongmin Li, Khalid Eltayef, and Xiaohui Liu

An Optimized Method for 3D Body Scanning Applications Based on KinectFusion ...... 100 Faraj Alhwarin, Stefan Schiffer, Alexander Ferrein, and Ingrid Scholl

Going Deeper into Colorectal Cancer Histopathology ...... 114 Francesco Ponzio, Enrico Macii, Elisa Ficarra, and Santa Di Cataldo

A Convolutional Neural Network for Spot Detection in Microscopy Images ...... 132 Matsilele Mabaso, Daniel Withey, and Bhekisipho Twala xxii Contents

Bioinformatics Models, Methods and Algorithms

Inferring the Synaptical Weights of Leaky Integrate and Fire Asynchronous Neural Networks: Modelled as Timed Automata ...... 149 Elisabetta De Maria and Cinzia Di Giusto

Formal Neuron Models: Delays Offer a Simplified Dendritic Integration for Free ...... 167 Ophélie Guinaudeau, Gilles Bernot, Alexandre Muzy, Daniel Gaffé, and Franck Grammont

Discovering Trends in Environmental Time-Series with Supervised Classification of Metatranscriptomic Reads and Empirical Mode Decomposition...... 192 Enzo Acerbi, Caroline Chénard, Stephan C. Schuster, and Federico M. Lauro

Health Informatics

How to Realize Device Interoperability and Information Security in mHealth Applications...... 213 Christoph Stach, Frank Steimle, and Bernhard Mitschang

Evaluation of Power-Based Stair Climb Performance via Inertial Measurement Units ...... 238 Sandra Hellmers, Sandra Lau, Rebecca Diekmann, Lena Dasenbrock, Tobias Kromke, Jürgen M. Bauer, Sebastian Fudickar, and Andreas Hein

Considerations on the Usability of SClínico ...... 262 João Pavão, Rute Bastardo, Luís Torres Pereira, Paula Oliveira, Victor Costa, Ana Isabel Martins, Alexandra Queirós, and Nelson Pacheco Rocha

Interoperability in Pervasive Health: A Systematic Review ...... 279 Ana Dias, Ana Isabel Martins, Alexandra Queirós, and Nelson Pacheco Rocha

Coping with “Exceptional” Patients in META-GLARE ...... 298 Alessio Bottrighi, Luca Piovesan, and Paolo Terenziani

A Multiagent-Based Model for Epidemic Disease Monitoring in DR Congo ...... 326 Jean-Claude Tshilenge Mfumu, Annabelle Mercier, Michel Occello, and Christine Verdier Contents xxiii

Predictive Modeling of Emerging Antibiotic Resistance Trends...... 348 M. L. Tlachac, Elke A. Rundensteiner, T. Scott Troppy, Kirthana Beaulac, Shira Doron, and Kerri Barton

Exploring the Value of Electronic Health Records from Multiple Datasets . . . 367 Olga Fajarda, Alina Trifan, Michel Van Speybroeck, Peter R. Rijnbeek, and José Luís Oliveira

Application of a Rule-Based Classifier to Data Regarding Radiation Toxicity in Prostate Cancer Treatment ...... 384 Juan L. Domínguez-Olmedo, Jacinto Mata, Victoria Pachón, and Jose L. Lopez Guerra

Detecting MRSA Infections by Fusing Structured and Unstructured Electronic Health Record Data ...... 399 Thomas Hartvigsen, Cansu Sen, and Elke A. Rundensteiner

Multi-layered Learning for Information Extraction from Adverse Drug Event Narratives ...... 420 Susmitha Wunnava, Xiao Qin, Tabassum Kakar, M. L. Tlachac, Xiangnan Kong, Elke A. Rundensteiner, Sanjay K. Sahoo, and Suranjan De

Application of Sample Entropy of Pulse Waves in Identifying Characteristic Physiological Patterns of Parkinson’s Disease Sufferers ...... 447 Mayumi Oyama-Higa, Tokihiko Niwa, Fumitake Ou, and Yoshifumi Kawanabe

META-GLARE’s Supports to Agent Coordination ...... 464 Luca Anselma, Alessio Bottrighi, Luca Piovesan, and Paolo Terenziani

Realistic Synthetic Data Generation: The ATEN Framework...... 497 Scott McLachlan, Kudakwashe Dube, Thomas Gallagher, Jennifer A. Simmonds, and Norman Fenton

Author Index ...... 525