DOCSLIB.ORG

CASE REPORT Carotid Body Tumor As a Reversible Cause of Syncope

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
CASE REPORT Carotid Body Tumor As a Reversible Cause of Syncope CASE REPORT Carotid Body Tumor as a Reversible Cause of Syncope Paul Harlan Singh Janda, DO; Venkatachalam Veerappan, MD; Mark E. McKenzie, MD; and Neel V. Dhudshia, MD The causes of syncope are diverse and extensive; carotid In the current report, we present the case of a patient body tumors are an extremely rare cause of syncope. These with syncope who, after other causes had been ruled out, was rare neoplasms represent less than 0.5% of all head and neck found to have a right-sided carotid body tumor as the cause tumors. The authors present a case of a woman with syncope of her condition. We also review the history, presentation, who was found to have a right-sided carotid body tumor. epidemiology, etiology, diagnosis, management, and prog - After surgical resection was performed, she did not have nosis of this condition. any additional syncopal or near-syncopal events. The authors provide a review of the literature on the natural history, pre - Report of Case sentation, and preferred management of carotid body tumors. Our patient was a 75-year-old white woman with a medical his - With modern diagnostic tools and treatment options, most tory that included hypertension, type 2 diabetes mellitus, and patients with this diagnosis can expect to recover fully. a prolapsed bladder. She was admitted to the hospital with a J Am Osteopath Assoc . 2011;111(11):638-644 chief complaint of syncope and left hip pain secondary to her fall. She reported having approximately 4 or 5 near-syncopal episodes before this admission. These earlier events consisted yncope is defined as the abrupt loss of consciousness of a sensation of dizziness but did not result in loss of con - Swith loss of postural tone. Approximately one-third of sciousness or postural tone. However, they were increasing in 1 individuals will have a syncopal episode during their lifetime. frequency. The patient reported that the events were occa - 2 According to Manolis et al, syncope is the reason for up to sionally linked to her position (ie, standing) and occurred at dif - 5% of all emergency department admissions. However, the ferent times throughout the day. She had no history of seizures causes of syncope are diverse and extensive; syncopes that or stroke. originate from vasodepressor, cardiogenic, and orthostatic Her syncopal episode occurred while she was standing at 3 causes are among the most common. the sink in her bathroom. She reported experiencing a pro - Carotid body tumors are rare neoplasms that are also drome of dizziness before falling to the floor. She stated that referred to as carotid body paragangliomas because they arise she had a rapid recovery, crawled to the toilet for positional 4 from paraganglionic cells. Carotid body tumors are an support, and then called out to her family members, asking 4-6 extremely rare cause of syncope, representing less than 0.5% them to phone for emergency medical services. The patient was 7 of all head and neck tumors. We reviewed the literature and neither disoriented nor weak after the episode and had no 8,9 found few reports of patients with these tumors. associated bowel or bladder incontinence or any oropharyn - geal trauma. Although she had type 2 diabetes mellitus, she was normoglycemic at her home when she was tended to by emergency medical services. During physical examination at admission, the patient appeared to be her stated age and was in no acute distress; she was awake, alert, and oriented. Her vital signs were stable. Her neck was not obese, enabling the physician (P.H.S.J.) to palpate a small, pulsatile right-sided mass with some mild tender - From the departments of neurology (Drs Janda and Veerappan), internal ness to light pressure. Except for this finding, the physical medicine (Dr McKenzie), and cardiothoracic surgery (Dr Dhudshia) at Valley examination findings were within normal limits for the patient’s Hospital Medical Center in Las Vegas, Nevada. Financial Disclosures: None reported. age. Address correspondence to Paul Harlan Singh Janda, DO, Valley Hospital On day 1, several diagnostic studies were performed. An Medical Center, 620 Shadow Ln, Las Vegas, NV 89106-4119. electrocardiogram exhibited normal sinus rhythm; an echocar - E-mail: [email protected] diogram showed an ejection fraction of 60% with mild, con - Submitted March 1, 2011; final revision received August 10, 2011; accepted centric left ventricular hypertrophy. Her orthostatic vital signs August 11, 2011. were unremarkable. Plasma metanephrine levels were mea - 638 • JAOA • Vol 111 • No 11 • November 2011 Janda et al • Case Report CASE REPORT sured and were within normal limits. A computed tomo - patient was informed of the risks and benefits of the procedure graphic (CT) scan of the brain without contrast material and agreed to proceed. The operation was uncomplicated. enhancement was unremarkable. The patient’s heart rate was At resection, the tumor appeared to be a highly vascu - monitored telemetrically and exhibited a sinus cardiac rhythm larized, solid mass resembling a tuft of capillaries. It was sent throughout her hospital stay. to the pathologist for histologic analysis. Histologic findings On day 2, results from magnetic resonance (MR) imaging were typical of a carotid body tumor and indicated no signs of of the brain, performed with and without gadolinium con - malignancy. Sections of the tumor appeared highly vascular, trast enhancement, demonstrated no acute changes or with cells palisaded by surrounding blood vessels. There were abnormal enhancement; only scant chronic white matter numerous cell clusters in zellballen formation, separated by a changes were noted. An MR angiogram of the brain was unre - prominent vascular stroma that is pathognomonic for carotid markable. An electroencephalogram was within normal limits body tumors. Hematoxylin-eosin staining revealed chief cells— and showed no areas of focal slowing and no spikes or sharp type I cells that are APUD (amine precursor uptake and decar - wave activities. Results from duplex Doppler carotid ultra - boxylation) cells with copious cytoplasm and large round sonography revealed normal carotid and vertebral arteries; it nuclei ( Figure 2 ), and S100 staining revealed the elongated also demonstrated a 1.5-cm nodule that was near the thyroid type II supporting cells ( Figure 3 ) that are also found in carotid gland but situated between the bifurcation of the right common body tumors. carotid artery into the right internal and external carotid The patient had no postoperative complications and exhib - arteries. ited no nerve damage or deficits. She was closely followed On the third day, 3-dimensional CT angiography of the up for 15 months after hospital discharge and had no additional neck and CT of the neck with iopamidol contrast enhance - syncopal or near-syncopal episodes. ment (Isovue-370, 100 mL) was performed, and results from these tests demonstrated a 1.7-cm mass with an intense vascular Comment and Review of Literature blush at the bifurcation of the right common carotid artery Historical Background (Figure 1 ). The findings were deemed to be consistent with a A carotid body tumor is a rare neoplasm of the carotid body carotid body tumor. that was first described by Lushka in 1862. 10 In 1880, Riegner The vascular surgery department was consulted on day attempted the first surgical resection, which resulted in the 3 and recommended surgical resection of the tumor. The death of the patient. 11,12 Maydl’s resection attempt in 1886 A B Figure 1. Three-dimensional computed tomographic (CT) angiogram (A) and transverse CT scan (B) of the neck of a 75-year-old woman presenting with complaint of sycope. The images revealed a 1.7-cm carotid body tumor (arrows) at the bifurcation of the right common carotid artery. Janda et al • Case Report JAOA • Vol 111 • No 11 • November 2011 • 639 CASE REPORT Figure 2. Histologic analysis of a tumor in a 75-year-old woman revealed Figure 3. Histologic analysis of a tumor in a 75-year-old woman revealed numerous chief cells in the pathognomonic zellballen cluster formation elongated sustentacular cells that are pathognomonic for carotid body (arrow), separated by a vascular stroma (hematoxylin-eosin stain; orig - tumors (S100 stain; original magnification, ×40). inal magnification, ×40). was reportedly successful, but the procedure caused sub - the lesion and is caused by the external carotid artery. 11 Rarely, stantial, irreversible residual complications of aphasia and carotid body tumors secrete catecholamines, which can result hemiplegia in his patient. The first published report of resec - in hypertension. 11,19 Our patient’s metanephrine levels were tion of a carotid body tumor with preservation of the carotid within normal limits, and she did not exhibit any hemody - arteries was by Scuddder in 1903. 11,12 In 1940, Gordon-Taylor namic instability. The majority of patients with carotid body illustrated an appropriate plane of dissection for the proce - tumors are asymptomatic until the tumor enlarges; carotid dure. 13 In 1953, Morfit et al 14 described arterial reconstruction body tumors expand slowly, with a growth rate of 0.5 cm per techniques, offered operative recommendations, and provided year. 4,7,9 Syncope, dizziness, and transient ischemic attacks the first documented report of a successful carotid body tumor are very rare presentations. 20 More frequent presentations are resection. A major publication by Shamblin et al 15 provided a neck discomfort, dysphagia, or dyspnea due to the size of the reliable template for categorizing carotid body tumors based mass, or hoarseness, dysphagia, or tongue weakness due to cra - on the degree of encirclement of the carotid arteries, a system nial nerve involvement. 11 Specifically, the 8th through 12th that is still used today. cranial nerves may be involved. Involvement of the mandibular Although carotid body tumors have been reported in the branch of the seventh cranial nerve has been reported but is literature for many years, syncope has rarely been mentioned rare.
Load more

Recommended publications
  • Oxygen Chemoreception by Carotid Body Cells in Culture (Glomus Cells/Dopamine/Hypoxia/Sensory Cells) MARK C
    Proc. Nati. Acad. Sci. USA Vol. 82, pp. 1448-1450, March 1985 Cell Biology Oxygen chemoreception by carotid body cells in culture (glomus cells/dopamine/hypoxia/sensory cells) MARK C. FISHMAN*t#§¶, WILLIAM L. GREENEt§, AND DoRos PLATIKAt¶ *Howard Hughes Medical Institute, tThe Developmental Biology Laboratory (Medical Services), and *Neurology Services of the Massachusetts General Hospital, Boston, MA 02114; and Departments of §Medicine and ¶Neurology, Harvard Medical School, Boston, MA 02115 Communicated by Jerome Gross, October 29, 1984 ABSTRACT Chemoreceptors for oxygen reside within the enrichment procedure. Hypoxic conditions were identical carotid body, but it is not known which cells actually sense except that the Po2 was diminished to 36 mm Hg. Since there hypoxia and by what mechanisms they transduce this informa- are only a few thousand cells in the carotid body, each ex- tion into afferent signals in the carotid sinus nerve. We have periment necessitated the pooling of dissociated cells of 10- developed systems for the growth of glomus cells of the carotid 12 rats and subsequent distribution to two plates, one to be body in dissociated cell culture. Here we demonstrate that, as used for control and one for hypoxic conditions. Cells in in vivo, these cells contain the putative neurotransmitters do- both plates for each experiment were grown in culture for pamine, serotonin, and norepinephrine. Oxygen tension regu- the same period of time. Experiments were performed after lates the rate of dopamine secretion from the glomus cells. culturing of the cells for 5-7 days. Similar to chemically stimulated catecholamine secretion from Prior to testing the cells were washed twice in Hanks' bal- other adrenergic cells this hypoxia-stimulated release requires anced salt solution supplemented with 100 ,uM pargyline/5 extracellular calcium.
    [Show full text]
  • Carotid Sinus Syndrome As a Manifestation of Head and Neck
    Mehta et al. Int J Clin Cardiol 2014, 1:2 ISSN: 2378-2951 International Journal of Clinical Cardiology Research Article: Open Access Carotid Sinus Syndrome as a Manifestation of Head and Neck Cancer - Case Report and Literature Review Nikhil Mehta*, Medhat Abdelmessih, Lachlan Smith, Daniel Jacoby and Mark Marieb Yale School of Medicine, USA *Corresponding author: Nikhil Mehta, 1180 Chapel Street, New Haven, CT-06511, USA, E-mail: [email protected] In 1799, Parry noticed that the heart rate can be slowed by Abstract applying pressure over one of the carotid sinuses [3]. An exaggerated Head and neck cancers rarely manifest as Carotid Sinus Syndrome response to this maneuver is called Carotid Sinus Hypersensitivity (CSS). CSS is a rare complex of symptoms found in 1% of all (CSH). Most patients with CSH are asymptomatic [4,5]. However, patients who experience syncope, the pathophysiology of which is sometimes CSH can manifestas hypotension, cerebral ischemia, yet to be fully understood. Common trigger mechanisms for CSS spontaneous dizziness or syncope, and this is termed Carotid Sinus include neck movement, shaving, constricting neck wear, coughing, sneezing and straining to lift heavy objects. The left carotid sinus Syndrome (CSS). The incidence of CSS increases with advancing age mainly causes AV block while the right carotid sinus mainly causes [2,6]. Spontaneous CSS is a rare phenomenon, found in 1 percent of sinus bradycardia. The incidence of AV block in CSS is very low all cases of syncope [4]. Induced CSS is much more common, found (4.9 to 16.7%) as reported in many case series.
    [Show full text]
  • Carotid Body Detection on CT Angiography
    ORIGINAL RESEARCH Carotid Body Detection on CT Angiography R.P. Nguyen BACKGROUND AND PURPOSE: Advances in multidetector CT provide exquisite detail with improved L.M. Shah delineation of the normal anatomic structures in the head and neck. The carotid body is 1 structure that is now routinely depicted with this new imaging technique. An understanding of the size range of the E.P. Quigley normal carotid body will allow the radiologist to distinguish patients with prominent normal carotid H.R. Harnsberger bodies from those who have a small carotid body paraganglioma. R.H. Wiggins MATERIALS AND METHODS: We performed a retrospective analysis of 180 CTAs to assess the imaging appearance of the normal carotid body in its expected anatomic location. RESULTS: The carotid body was detected in Ͼ80% of carotid bifurcations. The normal size range measured from 1.1 to 3.9 mm Ϯ 2 SDs, which is consistent with the reported values from anatomic dissections. CONCLUSIONS: An ovoid avidly enhancing structure at the inferomedial aspect of the carotid bifurca- tion within the above range should be considered a normal carotid body. When the carotid body measures Ͼ6 mm, a small carotid body paraganglioma should be suspected and further evaluated. ABBREVIATIONS: AP ϭ anteroposterior; CTA ϭ CT angiography he carotid body is a structure usually located within the glomus jugulare; and at the cochlear promontory, a glomus Tadventitia of the common carotid artery at the inferome- tympanicum.5 There have been rare reports of paraganglio- dial aspect of the carotid
    [Show full text]
  • Carotid Chemoreflex Endocrine Vasoconstrictors #NO Nitric
    Fetal hypoxia Glossopharyngeal (IXth) nerve Cardiovascular centre in medulla Carotid body and sinus Vagus (Xth) nerve nerve Carotid chemoreflex Endocrine vasoconstrictors Sympathetic chain Vasculature Vascular oxidant tone •O - •NO 2 : Superoxide Anion Nitric Oxide The Fetal Brain Sparing Response to Hypoxia: Physiological Mechanisms Dino A Giussani Department of Physiology, Development & Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK Journal: Journal of Physiology Submission: Invited Review Key Words: Fetus, Hypoxia, Cardiovascular, Chemoreflex, Nitric Oxide, Reactive Oxygen Species, IUGR, Intra-partum hypoxia, Asphyxia, Cerebral palsy Running Title: Fetal Brain Sparing Correspondence: Professor Dino A Giussani, Ph.D. Department of Physiology Development & Neuroscience Downing Street University of Cambridge Cambridge CB2 3EG UK Tel: +44 1223 333894 E-mail: [email protected] 1 1 ABSTRACT 2 3 How the fetus withstands an environment of reduced oxygenation during life in the 4 womb has been a vibrant area of research since this field was introduced by Joseph 5 Barcroft, a century ago. Studies spanning five decades have since used the 6 chronically instrumented fetal sheep preparation to investigate the fetal 7 compensatory responses to hypoxia. This defence is contingent on the fetal 8 cardiovascular system, which in late gestation adopts strategies to decrease oxygen 9 consumption and redistribute the cardiac output away from peripheral vascular 10 beds and towards essential circulations, such as those perfusing the brain. The 11 introduction of simultaneous measurement of blood flow in the fetal carotid and 12 femoral circulations by ultrasonic transducers has permitted investigation of the 13 dynamics of the fetal brain sparing response for the first time.
    [Show full text]
  • Cardiovascular Responses to Hypoxemia in Sinoaortic-Denervated Fetal Sheep
    003 1-399819 1 /3004-038 1$03.0010 PEDIATRIC RESEARCH Vol. 30. No. 4, I991 Copyright ID1991 International Pediatric Research Foundation. Inc. I1riiirc~c/it1 U.S. ,.I Cardiovascular Responses to Hypoxemia in Sinoaortic-Denervated Fetal Sheep JOSEPH ITSKOVITZ (ELDOR), EDMOND F. LAGAMMA. JAMES BRISTOW, AND ABRAHAM M. RUDOLPH Ccirdiovascz~karResearch Instillrle. Unlver:c.i/yqf Califi~rniu,Sari Francisco. Sun Francisco. Cu11fi)rilia94/43 ABSTRACT. Fetal cardiovascular response to acute hy- hypoxemia in postnatal life (1 3). The vascular effects of periph- poxemia is characterized by bradycardia, hypertension, and eral chemoreceptor stimulation, with ventilation held constant, redistribution of cardiac output. The role of aortic and include coronary vasodilation and vasoconstriction in the carotid chemoreceptors in mediating these responses was splanchnic organs and the skeletal muscles. Stimulation of the examined in eight sinoaortic-denervated and nine sham- carotid body chemoreceptors results in reflex bradycardia and operated fetal lambs. Blood gases, pH, heart rate, arterial negative inotropic responses. The bradycardia and peripheral pressure, and blood flow distribution were determined be- vasoconstriction during carotid chemoreceptor stimulation can fore and during hypoxemia. In intact fetuses, heart rate be reversed by effects arising from concurrent hypernea (13). fell from 184 -+ 12 to 165 + 23 beatslmin (p< 0.01) but The arterial chemoreceptors (aortic and carotid bodies) are increased from 184 + 22 to 200 + 16 beatslmin (p< 0.05) active in the fetal lamb and are responsive to hypoxemia (14- in the sinoaortic-denervated fetuses. Intact fetuses showed 21). Stimulation of the fetal arterial chemoreceptors result in an early hypertensive response to hypoxemia, whereas the bradycardia, which is abolished by SAD (19, 20, 22).
    [Show full text]
  • Carotid Bodies and Breathing in Humans Thorax: First Published As 10.1136/Thx.49.11.1081 on 1 November 1994
    Thorax 1994;49:1081-1084 1081 Carotid bodies and breathing in humans Thorax: first published as 10.1136/thx.49.11.1081 on 1 November 1994. Downloaded from The first report to describe the carotid bodies ("ganglion clearly demonstrated in the cat.5 The carotid bodies are minutem") was a dissertation published in 1743 by Taube,l therefore the organs which subserve hypoxic ventilatory although initially there was some uncertainty as to whether responsiveness in humans; consequently, they play a vital it was Taube or his professor (Professor Haller who used the part in constraining the fall of arterial Po2 in response to term "ganglion exiguum") who was the actual discoverer.* the challenge of hypoxaemia. While other investigators continued to report that they The most convincing evidence supporting this con- had "discovered" these organs (now termed the "ganglion tention comes from studies performed in subjects who intercaroticum") even as late as the middle of the 19th have had both carotid bodies surgically resected (see century, it remained for de Castro's detailed anatomical below). These subjects have no hyperpnoea in response to characterisation to provide the great advance in the un- experimentally induced hypoxaemia,67 nor do they show a derstanding of the structures. While he did not actually decline in ventilation following the abrupt and surreptitious use the term "chemoreceptors" as such, it is hard to believe administration of 100% oxygen against an hypoxic back- that he had anything else in mind when he stated2 that ground.7 However, in tests in which the alveolar - and they function to "taste the blood".
    [Show full text]
  • Deactivation of Carotid Body Chemoreceptors by Hyperoxia Decreases Blood Pressure in Hypertensive Patients
    Hypertension Research (2014) 37, 858–862 & 2014 The Japanese Society of Hypertension All rights reserved 0916-9636/14 www.nature.com/hr ORIGINAL ARTICLE Deactivation of carotid body chemoreceptors by hyperoxia decreases blood pressure in hypertensive patients Maciej Sinski1, Jacek Lewandowski1, Jacek Przybylski2, Pawe" Zalewski3, Bartosz Symonides1, Piotr Abramczyk1 and Zbigniew Gaciong1 Previous studies have shown that hyperoxia-induced deactivation of carotid body chemoreceptors reduces sympathetic activity in hypertensive patients but it does not affect blood pressure. The maintenance of blood pressure can be explained by the direct, vasoconstrictive effect of hyperoxia, which offsets diminished sympathetic activity. This study compares the effect of acute hyperoxia on hemodynamic parameters between hypertensive and normotensive subjects. Twelve males with hypertension (age 39.4±2.4 years; body mass index 27.4±1.1 kg m À2) and 11 normotensive males (age 39.9±2.7 years; body mass index 25.4±0.7 kg m À2) received, via non-rebreathing mask ventilation, ambient air, followed by 100% oxygen for 20 min. The stroke volume, heart rate, cardiac output, blood pressure, total peripheral resistance, respiratory rate, baroreceptor control of heart rate and oxygen saturation were recorded continuously. Several 30 s periods were analyzed before, during and after inducing hyperoxia. At baseline, the hypertensive subject’s blood pressure was higher and their baroreflex control of heart rate was lower when compared with the normotensive control group. After the first 30 s of hyperoxia, systolic, diastolic and mean blood pressures, as well as the total peripheral resistance, decreased significantly in hypertensives but not in normotensives. After 20 min of 100% oxygen ventilation, systolic and mean blood pressures and total peripheral resistance was increased in hypertensive patients, and the cardiac output and stroke volume had decreased in both groups.
    [Show full text]
  • Necessity of Adequate Monitoring During Carotid Body Tumors
    380 Olgu Sunumlar› Case Reports Necessity of adequate monitoring during carotid body tumors Karotis tümör rezeksiyonlarında yeterli monitorizasyon gerekliliği Ayşe Baysal, Ahmet Şaşmazel*, Onursal Buğra*, Rahmi Zeybek* From Departments of Anesthesiology and *Cardiovascular Surgery, Kartal Koşuyolu High Speciality Training and Research Hospital, İstanbul, Turkey Introduction Carotid body tumors are rare, benign, vascular, slow growing and invasive to adjacent structures. The tumor originates from the neural crest paraganglion cells (1). Infiltration into the adjacent tissues and into the jugular vascular area requires surgical excision (2). During surgery intraluminal shunt procedure is usually required (3). The goal in the presentation of these case reports is to discuss preoperative angiographic findings and different monitoring options for cerebral ischemia prevention during removal of carotid body tumors (3, 4). Case Report 1 A 34-year-old woman presented with a mass on the left side of her neck and palsy of the left upper eyelid. On examination, she had symptoms of Horner’s syndrome and a pulsatile solid mass of 6 x 8 cm. A carotid arteriography revealed a classic Lyre sign (Fig. 1). During surgery, in addition to the intraoperative standard monitorization that included electrocardiogram, invasive blood pressure monitoring, pulse oximetry, temperature probe and central venous pressure monitoring, bispectral index monitoring (BIS) was Figure 1. A classic “Lyre sign” with broad splaying of the internal and added for cerebral ischemia detection. Mean arterial pressure was kept external carotid arteries was seen in carotid arteriography CCA - common carotid artery, ECA - external carotid artery ICA- internal carotid artery between 80 to 100 mmHg during surgery. BIS under general anesthesia ranged between 40 and 60 values.
    [Show full text]
  • Mistchenko V.P., Tkachenko E.V
    1 Mistchenko V.P., Tkachenko E.V. NORMAL PHYSIOLOGY (SHORT LECTION COURSE FOR THE STUDENTS OF MEDICAL DEPARTMENT) POLTAVA- 2005 1 2 Dear students! In a brief course of our lectures on normal physiology for the students of medical faculty, offered to you, the basic concepts about all human organism systems functionning are stated. It is natural, that because of material statement brevity due to very much lectures amount, they can not give the complete answer to numerous questions, which can appear at their reading, all the more so there is no illustrative material in them. However, from our point of view, these lectures can be good addition to the existing textbooks and manuals. All the more so we read lectures from a position of clinical physiology, and not just from those classical performances about physiology, which are stated in the bulk of educational literature. It all does not mean, that in our lectures the knowledge of classical physiology is not used. The thing is that the knowledge is so quickly replenishes with the new items of information, that the known textbooks and manuals at any stage and in any sections obviously lag behind modernity. Lectures contain as well the data, which undoubtedly can be very useful to you at a study of internal diseases, surgery and other clinical disciplines. Believe our experience, you, being trained on the senior courses, will open these lectures time and again! We wish a success to you! Yours faithfully, professor V.P.Mishenko and assistant E.V.Tkachenko. 2 3 Lecture 1 (Introductional) Physiology as a science.
    [Show full text]
  • Striking Parallels Between Carotid Body Glomus Cell and Adrenal Chroma N MARK Cell Development
    Developmental Biology 444 (2018) S308–S324 Contents lists available at ScienceDirect Developmental Biology journal homepage: www.elsevier.com/locate/developmentalbiology ffi Striking parallels between carotid body glomus cell and adrenal chroma n MARK cell development Dorit Hockmana,b,c,1, Igor Adameykod,e, Marketa Kauckad, Perrine Barrauda, Tomoki Otania, Adam Hunta, Anna C. Hartwigf, Elisabeth Sockf, Dominic Waitheg, Marina C.M. Franckh,2, Patrik Ernforsh, Sean Ehingeri,3, Marthe J. Howardi, Naoko Brownj,Jeffrey Reesej, ⁎ Clare V.H. Bakera, a Department of Physiology, Development and Neuroscience, University of Cambridge, Anatomy Building, Downing Street, Cambridge CB2 3DY, United Kingdom b Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom c Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa d Department of Physiology and Pharmacology, Karolinska Institute, S-171 77 Stockholm, Sweden e Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria f Institut für Biochemie, Emil-Fischer-Zentrum, Friedrich-Alexander-Universität Erlangen-Nürnberg, Fahrstrasse 17, 91054 Erlangen, Germany g Wolfson Imaging Centre, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, United Kingdom h Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-171 77 Stockholm, Sweden i Department of Neurosciences and Program in Neurosciences and Neurodegenerative Diseases, University of Toledo Health Sciences Campus, Toledo, OH 43614, USA j Depts. of Pediatrics, Cell and Developmental Biology, Vanderbilt University Medical Center, 2215 B Garland Avenue, Nashville, TN 37232, USA ARTICLE INFO ABSTRACT Keywords: Carotid body glomus cells mediate essential reflex responses to arterial blood hypoxia.
    [Show full text]
  • Carotid Bodies in Animal Models of Human Disease: What Do They Teach Us? S15
    S14 Thorax 1994;49 Supplement:S14-S18 Carotid bodies in animal models of human Thorax: first published as 10.1136/thx.49.Suppl.S14 on 1 September 1994. Downloaded from disease: what do they teach us? Gwenda Barer Animals suffer their own diseases and rarely Hypoxic carotid body in man and animal afford us accurate pictures ofhuman afflictions. "models": morphology and physiology The argument is cogent that we can only learn In 1970 Heath and colleagues published a about human problems through the study of paper describing the carotid bodies in 40 con- humans. However, had we never investigated secutive necropsies. The weight of the carotid animals there are things we certainly would body was high in patients with emphysema, never have known. I contend that we would Pickwickian syndrome, and cor pulmonale, and not have discovered the respiratory function of a significant correlation was observed between the carotid body. In anaesthetised animals we the combined weights ofthe carotid bodies and can humanely cut and record from nerves, the weight of both the right and, unexpectedly, change gas tensions, give drugs and poisons. the left ventricle.3 In 1971 a further paper Animals can be exposed to environments which confirmed these findings.4 affect humans under controlled conditions, and In the following years the Liverpool group then compared with normal animals of similar produced a series of fascinating papers on rats age, sex, and life experience. Then there is the exposed chronically to hypoxia in a hypobaric morphological problem. Animal tissues can be chamber. They showed that the carotid body taken at the moment of death or before, so that enlarged rapidly, developed vascular en- the autolytic problems which beset pathologists gorgement and cellular changes at both the do not hold.
    [Show full text]
  • 26 Carotid and Aortic Bodies
    Carotid and Aortic Bodies An expanded area at the bifurcation of the carotid artery known as the carotid sinus contains numerous baroreceptors that function in the control of blood pressure by mediating changes in heart rate. Blood pressure is sensed by baroreceptors in specialized regions located in the carotid sinus and along the aortic arch. Baroreceptors (mechanoreceptors) respond to stretch and consist of myelinated sensory nerve fibers the bipolar neuronal cell bodies of which are located near the brain stem and project into the medulla of the brain. A decrease in blood pressure results in an increase in sympathetic stimulation and a release of norepinephrine. The action of norepinephrine is to stimulate cardiac activity and constrict blood vessels. Increase in blood pressure results in parasympathetic stimulation and release of acetylcholine. The action of acetylcholine is to slow cardiac activity and cause vasodilation. A small group of cells and nerve endings adjacent to the carotid sinus known as the carotid body senses the partial pressure of respiratory gases and pH in the arterial blood and also contributes to respiratory and cardiovascular reflex regulation. Carotid bodies are encapsulated structures that consist of masses of large, polyhedral epithelioid (glomus) cells that are closely related to a rich network of sinusoidal vessels. The cells have large, pale nuclei and light, finely granular cytoplasm. In electron micrographs, the granules show dense cores and contain catecholamines and 5-hydroxytryptamine. A second cell type, the type II glomus cell, appears much the same as type I but lacks granules and are thought be supporting glial cells. Aortic bodies are similar structures that lie close to the aorta between the angle of the subclavian and carotid arteries on the right and near the origin of the subclavian artery on the left.
    [Show full text]