antibiotics Article Biological Profiling of Semisynthetic C19-Functionalized Ferruginol and Sugiol Analogues Miguel A. González-Cardenete 1,* , Fatima Rivas 2 , Rachel Basset 2, Marco Stadler 3, Steffen Hering 3, José M. Padrón 4 , Ramón J. Zaragozá 5 and María Auxiliadora Dea-Ayuela 6,* 1 Instituto de Tecnología Química (UPV-CSIC), Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Avda. de los Naranjos s/n, 46022 Valencia, Spain 2 Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA;
[email protected] (F.R.);
[email protected] (R.B.) 3 Department of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria;
[email protected] (M.S.);
[email protected] (S.H.) 4 BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sanchez 2, 38200 La Laguna, Spain;
[email protected] 5 Departamento de Química Orgánica, Universidad de Valencia, Dr. Moliner 50, 46100 Burjassot, Spain;
[email protected] 6 Departamento de Farmacia, Facultad Ciencias de la Salud, Universidad CEU Cardenal Herrera, C/Ramón y Cajal s/n, 46115 Alfara del Patriarca, Spain * Correspondence:
[email protected] (M.A.G.-C.);
[email protected] (M.A.D.-A.) Abstract: The abietane-type diterpenoids are significant bioactive compounds exhibiting a varied range of pharmacological properties. In this study, the first synthesis and biological investigation of the new abietane-diterpenoid (+)-4-epi-liquiditerpenoid acid (8a) together with several of its analogs Citation: González-Cardenete, M.A.; are reported.