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Thrombosis in Africa: Past, Present and Future THROMBOSIS IN AFRICA: PAST, PRESENT AND FUTURE ThrombosisThrombosis in Africa:Africa: Past,Past, PresentPresent andand Future FebruaryFuture 28th - March 1st, 2018 Four Points Sheraton Hotel, Hurlingham,February 28th Nairobi - March - 1st,Kenya 2018 Four Points Sheraton Hotel, Hurlingham, Nairobi - Kenya PROGRAMME 1 THROMBOSIS IN AFRICA: PAST, PRESENT AND FUTURE Day One: Wednesday, February 28, 2018 TIME EVENT 8:45 AM Registration 9:00 AM THEME OF SESSION: STATUS OF THROMBOSIS IN AFRICA Dr M. D. Maina - Chair of session What is the most reasonable approach to diagnose and treat bleeding disorders in country/region and beyond? What are the next steps to improve management? Prof Malkit Riyat - Kenya The presentation will give regional experiences, perspectives and how to move forward 9:25AM Overview of The New Anticoagulants Dr Anne Mwirigi - Kenya 9:50AM Thrombosis Prophylaxis in country/region Dr Harun Otieno - Kenya The presentation will give the country/regional perspective in prophylaxis and treatment of thrombosis, including developments in developing national guidelines 10:15 AM QUESTIONS FOR SESSION SPEAKERS 10:40 AM REFRESHMENTS 11:10 AM THEME OF SESSION THROMBOTIC DISORDERS Dr Anne Mwirigi - Chair of session 11:35 AM Diagnosis of Thrombosis and Pulmonary Embolism in Country/region Current State Dr Anders Barasa - Kenya Thrombosis in Sickle Cell Disorder Dr. Elizabeth Kagotho - Kenya Participants will be presented with local country specific aspects in diagnosis and presentation of Thromboses and pulmonary embolism in country The presentation will focus on emerging paradigm shift relating procoagulant factors such as RBC TF decryption, PS expression, endothelial vWF release and microparticles in aetiology of thrombosis associated with Sickle cell crisis. 12:00 PM Inherited Thrombophilia rational for not testing Dr David Rabbolini - Australia Participants will gain an insight into thrombophilia risk factors, diagnostic criteria for testing, utility of information and when not order tests 2 THROMBOSIS IN AFRICA: PAST, PRESENT AND FUTURE Day One: Wednesday, February 28, 2018 TIME EVENT 12:25 PM QUESTIONS FOR SESSION SPEAKERS 1:00 PM LUNCH 2:00 PM THEME OF SESSION: PHARMACOLOGY OF VENOUS THROMBOSIS Dr Alice Kanyua - Chair of session Overview of The Old Anticoagulants Dr M. D. Maina - Kenya 2:30 PM What are the gaps in thrombosis and haemostasis research in Kenya and African region? Dr Nancy Okinda - Kenya 3:00 PM Oral presentations 3:30 PM Building international networks to improve patient care in Thrombosis and Hemostasis. Prof Steve Kitchen - UK 4:00 PM NETWORKING EVENING Day Two: Thursday, March 1, 2018 TIME EVENT 8:45 AM Registration 9:00 AM THEME OF THE SESSION: APPROACH TO BLEEDING DISORDERS Dr Gordon Ogweno - Chair of session 9:25AM How to approach a patient with a history of increased bleeding tendency? Focus on plasmatic disorders. Prof Steve Kitchen - UK This presentation will critically look into strengths and pitfalls of routine global assays of coagulation in the context of traditional and emerging concepts of coagulation. 9:50AM How to approach a patient with a history of increased bleeding tendency? Focus on von Willebrand disease Prof Johnny Mahlangu - RSA The presentation will focus on phenotypic tests available in the diagnosis of vWD. Participants will be provided with guidance on application and interpretation of these tests as a basis for rational therapy 10:15 AM How to approach a patient with a history of increased bleeding tendency? Focus on platelet disorders Dr David Rabbolini - Australia This presentation will provide overview of principles of platelet function testing in the context of clinical practice. It will present typical light transmission aggregometry (LTA) patterns in different disorders as well as choice of assay in in investigation of bleeding disorders. 3 THROMBOSIS IN AFRICA: PAST, PRESENT AND FUTURE Day Two: Thursday, March 1, 2018 TIME EVENT 10:40 AM QUESTIONS FOR SESSION SPEAKERS 11:05 AM REFRESHMENTS 11:30 AM THEME OF SESSION: DIAGNOSIS OF BLEEDING DISORDERS Dr Nancy Okinda, Chair of session Diagnosis and Treatment of Inherited Bleeding Disorders Dr Valarie Magutu-Kenya The presentation will present data in African context with special focus in the Kenyan situation. The content will cover racial and ethnic differences in clinical presentation and interpretation of laboratory data. 11:55 AM What are micro particles? Its relevance to thrombosis and cardiovascular disorders Dr Gordon Ogweno-Kenya The presentation will give an overview of science of blood microparticles, identification and relevance in haemostatis and thrombosis especially in cardiovascular disorders. 12:15 PM Womens’ health issues in hemostasis – bleeding Dr Patricia Muthaura - Kenya This presentation will give unique issues in bleeding disorders in women such as PPH, vWD and platelet disorders with regard to pregnancy complications, menstrual health and potential impact on and risk to the baby 12:40 PM QUESTIONS FOR SESSION SPEAKERS 1:00 PM LUNCH 2:30 PM THEME OF SESSION: ROLE OF INFECTION IN COAGULOPATHIES Dr Anne Barasa - Chair of session Malaria related coagulopathy-lessons learnt from vascular biology Dr Gordon Ogweno - Kenya The presentation will focus on parasite-endothelial interaction, placenta as a special case. It will give highlights of emerging concepts relating vWF, microparticles and platelets in the pathophysiology of cerebral malaria 3:00 PM HIV related coagulopathy-Role of platelets and endothelial interactions Dr Rael Onjula - Kenya Participants will gain an insight into HIV virus-platelets-endothelial triad in the pathophysiology of DVT, stroke and heart attacks. It will present current understanding of TTP in the background of HIV and HAART 3:30 PM QUESTIONS FOR SESSION SPEAKERS 4 THROMBOSIS IN AFRICA: PAST, PRESENT AND FUTURE Day Two: Thursday, March 1, 2018 TIME EVENT 4:00 PM MEET THE EXPERTS CHAIR Dr Beatrice Kabera - Kenya Meet the Experts (mentored by international experts) 4:30 PM Tropical disease, vWD or platelets, women’s health The international participants will discuss with the delegates in small groups real life cases from the participants experience 5:00 PM REFRESHMENT/SOCIAL EVENT/MEET THE EXPERTS Conference speakers Dr. Joseph M.D. Dr. Gordon Ogweno, Maina RCP ECLIN MB:ch.B: M.Med Consultant physician (Anaesth); PhD /haematology in Dr. Gordon is a Kenyatta National medical doctor Hospital. He is the and consultant founding Chairman of KSTH, member of anesthesiologist. He is currently the International Society Haemostasis and chairman department of Medical Thrombosis (ISTH) European Society Physiology at Kenyatta University School of Heamatology (EMA) and American of Medicine. society of Haematolgy (ASH). Dr Maina He graduated with MBchB and M.Medicine has special interest in Haemostasis and form the University of Nairobi and PhD thrombosis. in Medical Physiology (Thrombosis and Haemostasis) from Kenyatta Dr. Peter Waweru, University in 2016. He has had training Bpharm; MSC; PhD in Thromboelatography at University He is a lecturer in of Cape Town in South Africa, Platelet the department of aggregometry and Thrombin generation Medical Physiology at University of Maastricht. He is a School of Medicine, member of ISTH since 2012 sitting in University of Nairobi. He is currently the the subcommittees of Peroperative treasurer of KSTH. His research interests Haemotasis and platelets sub committes. are in the evaluation of traditional He is the founding Secretary General of medicines used in the management of KSTH. His research interests include VWF bleeding conditions and effects of animal and paltelets in HIV and adolescents with venom on coagulation. menorrhagia. 5 THROMBOSIS IN AFRICA: PAST, PRESENT AND FUTURE Conference speakers Anne Mwirigi, BSc, Dr. Elizabeth MBChB, MRCP, Kagotho FRCPath Dr.Elizabeth Kagotho Dr Mwirigi graduated is a medical doctor with a MBChB degree with Post graduate from the University training in Clinical of Glasgow in 2002, having also a pursued Pathology at the Aga Khan University an intercalated degree during her medical Hospital Nairobi ,2016. She is currently training and earning her Bsc (MedSci) in a Clinical Pathologist at the Aga Khan 2000 from the same university. University hospital, Nairobi. After 4 years of Internal Medicine training She is a member of the International in Glasgow and gaining Membership of the Society of thrombosis and haemostasis Royal College of Physicians in 2007, she (ISTH) and one of the founding members commenced her career in Hematology as of the Kenya society of thrombosis and a Senior House Officer at King’s College haemostasis (KSTH). Hospital in London. She thereafter became a Specialist Registrar at Guy’s She has a interest in Clinical Flow and St Thomas’ NHS Trust in 2009 and a cytometry for the diagnosis and Acute Fellow of the Royal College of Pathologist Leukemia and LPD’s and was trained on in Hematology in 2012. the same at the Toronto General Hospital , Toronto Canada. She also has a keen She obtained her Certificate of Completion interest in thrombosis and haemostasis of Training (CCT) in 2014, and later took up and is currently working on a number of consultant position for a period of two and studies on the same. a half years at both Guy’s and St Thomas’ and King’s College Hospitals. Steve Kitchen, PhD, FIBMS Dr. Mwirigi is an active member of various Current positions local and international hematological Professor Steve societies. Kitchen is the Lead Clinical With more than 10 years’ experience Scientist
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