Hydrogels Based on Schiff Base Linkages for Biomedical Applications
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Aldrich FT-IR Collection Edition I Library
Aldrich FT-IR Collection Edition I Library Library Listing – 10,505 spectra This library is the original FT-IR spectral collection from Aldrich. It includes a wide variety of pure chemical compounds found in the Aldrich Handbook of Fine Chemicals. The Aldrich Collection of FT-IR Spectra Edition I library contains spectra of 10,505 pure compounds and is a subset of the Aldrich Collection of FT-IR Spectra Edition II library. All spectra were acquired by Sigma-Aldrich Co. and were processed by Thermo Fisher Scientific. Eight smaller Aldrich Material Specific Sub-Libraries are also available. Aldrich FT-IR Collection Edition I Index Compound Name Index Compound Name 3515 ((1R)-(ENDO,ANTI))-(+)-3- 928 (+)-LIMONENE OXIDE, 97%, BROMOCAMPHOR-8- SULFONIC MIXTURE OF CIS AND TRANS ACID, AMMONIUM SALT 209 (+)-LONGIFOLENE, 98+% 1708 ((1R)-ENDO)-(+)-3- 2283 (+)-MURAMIC ACID HYDRATE, BROMOCAMPHOR, 98% 98% 3516 ((1S)-(ENDO,ANTI))-(-)-3- 2966 (+)-N,N'- BROMOCAMPHOR-8- SULFONIC DIALLYLTARTARDIAMIDE, 99+% ACID, AMMONIUM SALT 2976 (+)-N-ACETYLMURAMIC ACID, 644 ((1S)-ENDO)-(-)-BORNEOL, 99% 97% 9587 (+)-11ALPHA-HYDROXY-17ALPHA- 965 (+)-NOE-LACTOL DIMER, 99+% METHYLTESTOSTERONE 5127 (+)-P-BROMOTETRAMISOLE 9590 (+)-11ALPHA- OXALATE, 99% HYDROXYPROGESTERONE, 95% 661 (+)-P-MENTH-1-EN-9-OL, 97%, 9588 (+)-17-METHYLTESTOSTERONE, MIXTURE OF ISOMERS 99% 730 (+)-PERSEITOL 8681 (+)-2'-DEOXYURIDINE, 99+% 7913 (+)-PILOCARPINE 7591 (+)-2,3-O-ISOPROPYLIDENE-2,3- HYDROCHLORIDE, 99% DIHYDROXY- 1,4- 5844 (+)-RUTIN HYDRATE, 95% BIS(DIPHENYLPHOSPHINO)BUT 9571 (+)-STIGMASTANOL -
Part I: Carbonyl-Olefin Metathesis of Norbornene
Part I: Carbonyl-Olefin Metathesis of Norbornene Part II: Cyclopropenimine-Catalyzed Asymmetric Michael Reactions Zara Maxine Seibel Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Graduate School of Arts and Sciences COLUMBIA UNIVERSITY 2016 1 © 2016 Zara Maxine Seibel All Rights Reserved 2 ABSTRACT Part I: Carbonyl-Olefin Metathesis of Norbornene Part II: Cyclopropenimine-Catalyzed Asymmetric Michael Reactions Zara Maxine Seibel This thesis details progress towards the development of an organocatalytic carbonyl- olefin metathesis of norbornene. This transformation has not previously been done catalytically and has not been done in practical manner with stepwise or stoichiometric processes. Building on the previous work of the Lambert lab on the metathesis of cyclopropene and an aldehyde using a hydrazine catalyst, this work discusses efforts to expand to the less stained norbornene. Computational and experimental studies on the catalytic cycle are discussed, including detailed experimental work on how various factors affect the difficult cycloreversion step. The second portion of this thesis details the use of chiral cyclopropenimine bases as catalysts for asymmetric Michael reactions. The Lambert lab has previously developed chiral cyclopropenimine bases for glycine imine nucleophiles. The scope of these catalysts was expanded to include glycine imine derivatives in which the nitrogen atom was replaced with a carbon atom, and to include imines derived from other amino acids. i Table of Contents List of Abbreviations…………………………………………………………………………..iv Part I: Carbonyl-Olefin Metathesis…………………………………………………………… 1 Chapter 1 – Metathesis Reactions of Double Bonds………………………………………….. 1 Introduction………………………………………………………………………………. 1 Olefin Metathesis………………………………………………………………………… 2 Wittig Reaction…………………………………………………………………………... 6 Tebbe Olefination………………………………………………………………………... 9 Carbonyl-Olefin Metathesis……………………………………………………………. -
Fluorescent Aminal Linked Porous Organic Polymer for Reversible Iodine Capture and Sensing Muhammad A
www.nature.com/scientificreports OPEN Fluorescent aminal linked porous organic polymer for reversible iodine capture and sensing Muhammad A. Sabri1, Mohammad H. Al‑Sayah2, Susan Sen2, Taleb H. Ibrahim1 & Oussama M. El‑Kadri2* A novel triazene-anthracene-based fuorescent aminal linked porous organic polymer (TALPOP) was prepared via metal free-Schif base polycondensation reaction of 9,10-bis-(4,6-diamino-S‑triazin‑ 2-yl)anthracene and 2-furaldehyde. The polymer has exceptional chemical and thermal stabilities and exhibit good porosity with Brunauer–Emmett–Teller surface area of 401 m2g−1. The combination of such porosity along with the highly conjugated heteroatom-rich framework enabled the polymer to exhibit exceptional iodine vapor uptake of up to 314 wt % and reversible iodine adsorption in solution. Because of the inclusion of the anthracene moieties, the TALPOP exhibited excellent 3 −1 detection sensitivity towards iodine via forescence quenching with Ksv value of 2.9 × 10 L mol . The cost efective TALPOP along with its high uptake and sensing of iodine, make it an ideal material for environmental remediation. Nuclear energy is becoming one of the most feasible alternative sources to meet the ever-increasing energy demand and minimize the emission of greenhouse gases because of its high-density energy, minimal carbon footprints, and low operation cost1–4. Despite such advantages, the potential emissions of radioactive material 129 131 3 14 85 (such as I and I, H, CO2, and Kr) from nuclear energy power plants is a major drawback of this tech- nology due to the serious environmental and health efect of these materials4,5. -
(12) Patent Application Publication (10) Pub. No.: US 2009/0318437 A1 Gaeta Et Al
US 20090318437A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2009/0318437 A1 Gaeta et al. (43) Pub. Date: Dec. 24, 2009 (54) SUBSTITUTED PYRAZOLO15-APYRIDINE (60) Provisional application No. 60/811,604, filed on Jun. COMPOUNDS AND THER METHODS OF 6, 2006. USE (76) Inventors: Federico C.A. Gaeta, Mountain Publication Classification View, CA (US); Matthew Gross, (51) Int. Cl. Vallejo, CA (US); Kirk W. A63L/437 (2006.01) Johnson, Moraga, CA (US) C07D 47L/04 (2006.01) Correspondence Address: C07D 413/14 (2006.01) King & Spalding LLP A 6LX 3/5.377 (2006.01) P.O. BOX 889 A6IP II/06 (2006.01) Belmont, CA 94002-0889 (US) (52) U.S. Cl. ...................... 514/233.2:546/121; 544/127; (21) Appl. No.: 12/482,307 514/3OO (22) Filed: Jun. 10, 2009 Related U.S. Application Data (57) ABSTRACT (62) Division of application No. 1 1/810,885, filed on Jun. 6, The present invention is directed to substituted pyrazolo 1.5- 2007, now Pat. No. 7,585,875. apyridines and related methods for their synthesis and use. Patent Application Publication Dec. 24, 2009 Sheet 1 of 2 US 2009/0318437 A1 log threshold withdrawal (mg x 10) s s t | yme as w (s (f) pouseul emerpum 909 Y Patent Application Publication Dec. 24, 2009 Sheet 2 of 2 US 2009/0318437 A1 s o O O war C SSm S.t c) is . E E C C a S. & S. is 25 &(2 52 > w- we t : : log threshold withdrawal (mg x 10) N CN N. -
A Macroscopic Demonstration of the Malaprade Reaction † † † † E
Demonstration Cite This: J. Chem. Educ. 2019, 96, 1199−1204 pubs.acs.org/jchemeduc How To Shrink Paper Money: A Macroscopic Demonstration of the Malaprade Reaction † † † † E. Brandon Strong, Brittany A. Lore, Emily R. Christensen, Nathaniel W. Martinez, ‡ and Andres W. Martinez*, † ‡ Department of Biological Sciences and Department of Chemistry & Biochemistry, California Polytechnic State University, San Luis Obispo, California 93401, United States *S Supporting Information ABSTRACT: Shrinking paper money is a captivating and memorable demonstration of chemistry in action that can be carried out using minimal equipment and reagents. Paper bills can be shrunk down to ∼25% of their initial surface area by treating them with an aqueous solution of sodium periodate. The cellulose in the paper bill is oxidized to dialdehyde cellulose via the Malaprade reaction, and the resulting change in size of the paper money provides macroscopic evidence of the reaction. The chemical change that occurs in the cellulose can be confirmed by a Tollen’s test. KEYWORDS: General Public, Elementary/Middle-School Science, High School/Introductory Chemistry, First-Year Undergraduate/General, Second-Year Undergraduate, Demonstrations, Hands-On-Learning/Manipulatives, Alcohols, Aldehydes/Ketones, Oxidation/Reduction ■ INTRODUCTION In 1937, Jackson and Hudson reported that a piece of filter paper shrank to 25% of its original surface area upon reacting Paper money is arguably one of the most recognizable objects 14 in the world. Magicians, artists, and scientists have all with periodic acid. The shrinkage was later attributed to the capitalized on the popularity of banknotes by using them as reorganization of the dialdehyde cellulose chains into nonlinear props to capture the attention of the public. -
New Insights Into the Mechanism of Schiff Base Synthesis from Aromatic
A peer-reviewed version of this preprint was published in PeerJ on 15 December 2020. View the peer-reviewed version (peerj.com/articles/ochem-4), which is the preferred citable publication unless you specifically need to cite this preprint. Silva PJ. 2020. New insights into the mechanism of Schiff base synthesis from aromatic amines in the absence of acid catalyst or polar solvents. PeerJ Organic Chemistry 2:e4 https://doi.org/10.7717/peerj-ochem.4 New insights into the mechanism of Schiff base synthesis from aromatic amines in the absence of acid catalyst or polar solvents Pedro J Silva Corresp. 1 1 FP-ENAS/Fac. de Ciências da Saúde, Universidade Fernando Pessoa, Porto, Portugal Corresponding Author: Pedro J Silva Email address: [email protected] Extensive computational studies of the imine synthesis from amines and aldehydes in water have shown that the large-scale structure of water is needed to afford appropriate charge delocalisation and enable sufficient transition state stabilisation. These insights cannot, however, be applied to the understanding of the reaction pathway in apolar solvents due their inability to form extensive hidrogen-bonding networks. In this work, we perform the first computational studies of this reaction in apolar conditions. This density- functional study of the reaction of benzaldehyde with four closely related aromatic amines (aniline, o-toluidine, m-toluidine and p-toluidine) shows that an additional molecule of amine may provide enough stabilization of the first transition state even in the absence of a hydrogen bonding network. Our computations also show that the second reaction step cannot take place unless an extra proton is added to the system but, crucially, that reaction rate is so high that even picomolar amounts of protonated base are enough to achieve realistic rates. -
Nitroso and Nitro Compounds 11/22/2014 Part 1
Hai Dao Baran Group Meeting Nitroso and Nitro Compounds 11/22/2014 Part 1. Introduction Nitro Compounds O D(Kcal/mol) d (Å) NO NO+ Ph NO Ph N cellular signaling 2 N O N O OH CH3−NO 40 1.48 molecule in mammals a nitro compound a nitronic acid nitric oxide b.p = 100 oC (8 mm) o CH3−NO2 57 1.47 nitrosonium m.p = 84 C ion (pKa = 2−6) CH3−NH2 79 1.47 IR: υ(N=O): 1621-1539 cm-1 CH3−I 56 Nitro group is an EWG (both −I and −M) Reaction Modes Nitro group is a "sink" of electron Nitroso vs. olefin: e Diels-Alder reaction: as dienophiles Nu O NO − NO Ene reaction 3 2 2 NO + N R h 2 O e Cope rearrangement υ O O Nu R2 N N N R1 N Nitroso vs. carbonyl R1 O O O O O N O O hυ Nucleophilic addition [O] N R2 R O O R3 Other reaction modes nitrite Radical addition high temp low temp nitrolium EWG [H] ion brown color less ion Redox reaction Photochemical reaction Nitroso Compounds (C-Nitroso Compounds) R2 R1 O R3 R1 Synthesis of C-Nitroso Compounds 2 O R1 R 2 N R3 3 R 3 N R N R N 3 + R2 2 R N O With NO sources: NaNO2/HCl, NOBF4, NOCl, NOSbF6, RONO... 1 R O R R1 O Substitution trans-dimer monomer: blue color cis-dimer colorless colorless R R NOBF OH 4 - R = OH, OMe, Me, NR2, NHR N R2 R3 = H or NaNO /HCl - para-selectivity ΔG = 10 Kcal mol-1 Me 2 Me R1 NO oxime R rate determining step Blue color: n π∗ absorption band 630-790 nm IR: υ(N=O): 1621-1539 cm-1, dimer υ(N−O): 1300 (cis), 1200 (trans) cm-1 + 1 Me H NMR (α-C-H) δ = 4 ppm: nitroso is an EWG ON H 3 Kochi et al. -
Polycarbodiimides As Classification-Free and Easy to Use Crosslinkers for Water-Based Coatings
White paper Polycarbodiimides as classification-free and easy to use crosslinkers for water-based coatings By Dr. A.J. Derksen, Stahl International bv, The Netherlands Polycarbodiimides (CDl) selectively react with carboxylic acid (–COOH) groups in polymer chains. This type of crosslinking reaction results in a classic 3D polymer-crosslinker network. Compared to polyisocyanates, polycarbodiimides are much less sensitive to presence of water and able to achieve long pot lives. Due to the high reactivity, curing with CDI type crosslinkers can be done under room temperature or typical oven conditions used for drying of applied coatings. In addition to standard CDI crosslinker chemistry, on offer is also a range of dual reactivity CDI crosslinkers. A second type of reactive groups is attached to the polycarbodiimide in this range. Upon curing, this crosslinker not only reacts with the –COOH groups in the polymer chains, but also two of the reactive groups attached to the separate CDI molecules can couple to form an even denser network structure. Building further on the success of these polycarbodiimide crosslinkers, VOC-free polycarbodiimides, in aqueous delivery form, were introduced, which give extreme long pot lives. 1. Introduction when dealing with flexible substrates. A high level of crosslinking Crosslinking is widely practiced in nearly all the coating may be acceptable for hard coatings on rigid substrates, but industries in order to improve the performance of the coating. low levels may be best for soft coatings on extensible, flexible These improvements include wear, abrasion and chemical substrates such as rubber and leather. An important crosslinking resistances and toughness1. The improved performance originates system for aqueous resins involves the use of water-dispersible from the formation of a continuous three-dimensional network, oligomeric polyisocyanates. -
Origins of Life: Transition from Geochemistry to Biogeochemistry
December 2016 Volume 12, Number 6 ISSN 1811-5209 Origins of Life: Transition from Geochemistry to Biogeochemistry NITA SAHAI and HUSSEIN KADDOUR, Guest Editors Transition from Geochemistry to Biogeochemistry Staging Life: Warm Seltzer Ocean Incubating Life: Prebiotic Sources Foundation Stones to Life Prebiotic Metal-Organic Catalysts Protometabolism and Early Protocells pub_elements_oct16_1300&icpms_Mise en page 1 13-Sep-16 3:39 PM Page 1 Reproducibility High Resolution igh spatial H Resolution High mass The New Generation Ion Microprobe for Path-breaking Advances in Geoscience U-Pb dating in 91500 zircon, RF-plasma O- source Addressing the growing demand for small scale, high resolution, in situ isotopic measurements at high precision and productivity, CAMECA introduces the IMS 1300-HR³, successor of the internationally acclaimed IMS 1280-HR, and KLEORA which is derived from the IMS 1300-HR³ and is fully optimized for advanced U-Th-Pb mineral dating. • New high brightness RF-plasma ion source greatly improving spatial resolution, reproducibility and throughput • New automated sample loading system with motorized sample height adjustment, significantly increasing analysis precision, ease-of-use and productivity • New UV-light microscope for enhanced optical image resolution (developed by University of Wisconsin, USA) ... and more! Visit www.cameca.com or email [email protected] to request IMS 1300-HR³ and KLEORA product brochures. Laser-Ablation ICP-MS ~ now with CAMECA ~ The Attom ES provides speed and sensitivity optimized for the most demanding LA-ICP-MS applications. Corr. Pb 207-206 - U (238) Recent advances in laser ablation technology have improved signal 2SE error per sample - Pb (206) Combined samples 0.076121 +/- 0.002345 - Pb (207) to background ratios and washout times. -
WO 2012/044761 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date _ . 5 April 2012 (05.04.2012) WO 2012/044761 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 47/48 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, PCT/US201 1/053876 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 29 September 201 1 (29.09.201 1) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Langi English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. 12/893,344 29 September 2010 (29.09.2010) US (84) Designated States (unless otherwise indicated, for every (71) Applicant (for all designated States except US): UNI¬ kind of regional protection available): ARIPO (BW, GH, VERSITY OF NORTH CAROLINA AT WILMING¬ GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, TON [US/US]; 601 South College Road, Wilmington, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, NC 28403 (US). -
Research Journal of Pharmaceutical, Biological and Chemical Sciences
ISSN: 0975-8585 Research Journal of Pharmaceutical, Biological and Chemical Sciences Metal Complexes of Schiff's Bases Containing Sulfonamides Nucleus: A Review. Zainab Hussain1, Majid Khalaf2, Hadeel Adil2, Dheaa Zageer2, 3, Firas Hassan2, Salam Mohammed4, and Emad Yousif1*. 1Department of Chemistry, College of Science, Misan University, Misan, Iraq . 2Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq. 3Forensic DNA Center for Research and Training, Al-Nahrain University, Baghdad, Iraq. 4College of Engineering and Architecture, University of Nizwa, Birkat Almouz, 616 Nizwa, Oman. ABSTRACT Schiff's bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Schiff's bases play an important role in Inorganic chemistry due to formation of very stable complexes with various transition and inner-Transition Metals. Transition metal complexes derived from the Schiff base ligands have widly applications. This review summarizes some metal complexes of schiff's bases derived from sulfonamide derivatives and reviewed the applications of Schiff's bases chelates in quantitative analysis. Keywords: Schiff bases, Metal complexes, Quantitative analysis. *Corresponding author September – October 2016 RJPBCS 7(5) Page No. 1008 ISSN: 0975-8585 Overview of of Schiff's bases A Schiff's base is a nitrogen analog of an aldehyde or ketone in which the C=O group is replaced by C=N-R group. It is usually formed by condensation of an aldehyde or ketone with a primary amine according to the following scheme (Scheme 1): Scheme 1: Formation of Schiff's bases. Where R, may be an alkyl or an aryl group. Schiff's bases that contain aryl substituents are substantially more stable and more readily synthesized, while those which contain alkyl substituents are relatively unstable. -
Acetaldehyde Oxime Hazard Summary Identification
Common Name: ACETALDEHYDE OXIME CAS Number: 107-29-9 RTK Substance number: 0003 DOT Number: UN 2332 Date: March 1987 Revision: August 1998 ------------------------------------------------------------------------- ------------------------------------------------------------------------- HAZARD SUMMARY WORKPLACE EXPOSURE LIMITS * Acetaldehyde Oxime can affect you when breathed in and No occupational exposure limits have been established for by passing through your skin. Acetaldehyde Oxime. This does not mean that this substance * Contact can irritate the eyes and skin. is not harmful. Safe work practices should always be * Breathing Acetaldehyde Oxime can irritate the nose and followed. throat. * Acetaldehyde Oxime is a FLAMMABLE LIQUID and a * It should be recognized that Acetaldehyde Oxime can be FIRE HAZARD. absorbed through your skin, thereby increasing your exposure. IDENTIFICATION Acetaldehyde Oxime is a colorless liquid or crystalline WAYS OF REDUCING EXPOSURE (needle-like) solid. It is used to make other chemicals. * Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust REASON FOR CITATION ventilation or enclosure is not used, respirators should be * Acetaldehyde Oxime is on the Hazardous Substance List worn. because it is cited by DOT. * Wear protective work clothing. * This chemical is on the Special Health Hazard Substance * Wash thoroughly immediately after exposure to List because it is FLAMMABLE. Acetaldehyde Oxime and at the end of the workshift. * Definitions are provided on page 5. * Post hazard and warning information in the work area. In addition, as part of an ongoing education and training HOW TO DETERMINE IF YOU ARE BEING effort, communicate all information on the health and safety hazards of Acetaldehyde Oxime to potentially EXPOSED exposed workers.