Cytochrome P450 Drug Interaction Table

Home , Alprenolol, Aprepitant, Carisoprodol, Enflurane, Eplerenone, Felbamate

SUBSTRATES 1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A4,5,7 amitriptyline bupropion paclitaxel NSAIDs: Proton Pump Beta Blockers: Anesthetics: Macrolide antibiotics: caffeine cyclophosphamide torsemide diclofenac Inhibitors: carvedilol enflurane clarithromycin clomipramine efavirenz amodiaquine ibuprofen lansoprazole S-metoprolol halothane erythromycin (not clozapine ifosfamide cerivastatin lornoxicam omeprazole propafenone isoflurane 3A5) cyclobenzaprine methadone repaglinide meloxicam pantoprazole timolol methoxyflurane NOT azithromycin estradiol S-naproxen_Nor rabeprazole sevoflurane telithromycin fluvoxamine piroxicam Antidepressants: haloperidol suprofen Anti-epileptics: amitriptyline acetaminophen Anti-arrhythmics: imipramine N-DeMe diazepam Nor clomipramine NAPQI quinidine 3OH (not mexilletine Oral Hypoglycemic phenytoin(O) desipramine aniline2 3A5) naproxen Agents: S-mephenytoin imipramine benzene olanzapine tolbutamide phenobarbitone paroxetine chlorzoxazone Benzodiazepines: ondansetron glipizide ethanol alprazolam phenacetin_ amitriptyline Antipsychotics: N,N-dimethyl diazepam 3OH acetaminophen NAPQI Angiotensin II carisoprodol haloperidol formamide midazolam propranolol Blockers: citalopram perphenazine theophylline triazolam riluzole losartan chloramphenicol risperidone 9OH 8-OH ropivacaine irbesartan clomipramine thioridazine Immune Modulators: tacrine cyclophosphamide zuclopenthixol cyclosporine theophylline Sulfonylureas: hexobarbital tacrolimus (FK506) tizanidine glyburide imipramine N-DeME alprenolol verapamil glibenclamide indomethacin amphetamine HIV Antivirals: (R)warfarin glipizide R-mephobarbital aripiprazole indinavir zileuton glimepiride moclobemide atomoxetine nelfinavir zolmitriptan tolbutamide nelfinavir bufuralol ritonavir nilutamide chlorpheniramine saquinavir amitriptyline primidone chlorpromazine celecoxib progesterone codeine ( O-desMe) Prokinetic: fluoxetine proguanil debrisoquine cisapride fluvastatin propranolol dexfenfluramine glyburide teniposide dextromethorphan Antihistamines: nateglinide R-warfarin 8-OH duloxetine astemizole phenytoin-4-OH2 encainide chlorpheniramine rosiglitazone flecainide terfenadine tamoxifen fluoxetine torsemide fluvoxamine Calcium Channel S-warfarin lidocaine Blockers: metoclopramide amlodipine methoxyamphetamine diltiazem mexilletine felodipine minaprine lercanidipine nebivolol nifedipine2 nortriptyline nisoldipine ondansetron nitrendipine oxycodone verapamil perhexiline phenacetin HMG CoA Reductase phenformin Inhibitors: promethazine atorvastatin propranolol cerivastatin sparteine lovastatin tamoxifen NOT pravastatin tramadol simvastatin venlafaxine Steroid 6beta-OH: estradiol hydrocortisone progesterone testosterone

Miscellaneous: alfentanyl aprepitant aripiprazole buspirone cafergot caffeine_TMU cilostazol cocaine codeine- Ndemethylation dapsone dexamethasone dextromethorphan docetaxel domperidone eplerenone fentanyl finasteride gleevec haloperidol irinotecan LAAM lidocaine methadone nateglinide ondansetron pimozide propranolol quetiapine quinine risperidone NOT rosuvastatin salmeterol sildenafil sirolimus tamoxifen taxol terfenadine trazodone vincristine zaleplon ziprasidone zolpidem INHIBITORS 1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A4,5,7 fluvoxamine thiotepa gemfibrozil fluconazole PPIs: bupropion diethyl - HIV Antivirals: ciprofloxacin ticlopidine trimethoprim lansoprazole fluoxetine dithiocarbamate indinavir cimetidine glitazones amiodarone omeprazole paroxetine disulfiram nelfinavir amiodarone montelukast pantoprazole quinidine ritonavir fluoroquinolones quercetin fenofibrate rabeprazole furafylline fluvastatin duloxetine clarithromycin interferon fluvoxamine chloramphenicol terbinafine itraconazole methoxsalen isoniazid cimetidine ketoconazole mibefradil lovastatin felbamate amiodarone nefazodone phenylbutazone fluoxetine cimetidine saquinavir probenicid fluvoxamine sertraline telithromycin sertraline indomethacin sulfamethoxazole ketoconazole celecoxib aprepitant sulfaphenazole modafinil chlorpheniramine erythromycin teniposide oxcarbazepine chlorpromazine fluconazole voriconazole probenicid citalopram grapefruit juice zafirlukast ticlopidine clemastine verapamil topiramate clomipramine diltiazem cocaine diphenhydramine cimetidine doxepin doxorubicin amiodarone escitalopram NOT azithromycin halofantrine chloramphenicol histamine H1 ciprofloxacin receptor antagonists delaviridine hydroxyzine levomepromazine diethyl- methadone dithiocarbamate metoclopramide fluvoxamine mibefradil gestodene midodrine imatinib moclobemide mibefradil perphenazine mifepristone ranitidine norfloxacin red-haloperidol norfluoxetine ritonavir star fruit ticlopidine voriconazole tripelennamine

INDUCERS 1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A4,5,7 broccoli phenobarbital rifampin rifampin carbamazepine dexamethasone ethanol HIV Antivirals: brussel sprouts rifampin secobarbital norethindrone rifampin isoniazid efavirenz char-grilled meat NOT pentobarbital nevirapine insulin prednisone barbiturates methylcholanthrene rifampin carbamazepine modafinil efavirenz nafcillin glucocorticoids beta-naphthoflavone modafinil omeprazole nevirapine tobacco oxcarbazepine phenobarbital phenytoin pioglitazone rifabutin rifampin St. John's wort troglitazone