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Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances Joshua Zolton Seither [email protected]
Florida International University FIU Digital Commons FIU Electronic Theses and Dissertations University Graduate School 4-25-2018 Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances Joshua Zolton Seither [email protected] DOI: 10.25148/etd.FIDC006565 Follow this and additional works at: https://digitalcommons.fiu.edu/etd Part of the Chemistry Commons Recommended Citation Seither, Joshua Zolton, "Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances" (2018). FIU Electronic Theses and Dissertations. 3823. https://digitalcommons.fiu.edu/etd/3823 This work is brought to you for free and open access by the University Graduate School at FIU Digital Commons. It has been accepted for inclusion in FIU Electronic Theses and Dissertations by an authorized administrator of FIU Digital Commons. For more information, please contact [email protected]. FLORIDA INTERNATIONAL UNIVERSITY Miami, Florida APPLICATION OF HIGH RESOLUTION MASS SPECTROMETRY FOR THE SCREENING AND CONFIRMATION OF NOVEL PSYCHOACTIVE SUBSTANCES A dissertation submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in CHEMISTRY by Joshua Zolton Seither 2018 To: Dean Michael R. Heithaus College of Arts, Sciences and Education This dissertation, written by Joshua Zolton Seither, and entitled Application of High- Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances, having been approved in respect to style and intellectual content, is referred to you for judgment. We have read this dissertation and recommend that it be approved. _______________________________________ Piero Gardinali _______________________________________ Bruce McCord _______________________________________ DeEtta Mills _______________________________________ Stanislaw Wnuk _______________________________________ Anthony DeCaprio, Major Professor Date of Defense: April 25, 2018 The dissertation of Joshua Zolton Seither is approved. -
2019 Conference Program
First Floor Third Floor Fourth Floor Fifth Floor Note: The Armstrong Ballroom is on the eighth floor. CREATIVITY AND INNOVATION IN HONORS 2019 NCHC Annual Conference November 6-10, 2019 • New Orleans, LA • Sheraton New Orleans NATIONAL COLLEGIATE HONORS COUNCIL Welcome to the 54th Annual Conference of the National Collegiate Honors Council Greetings, Honors Colleagues: On behalf of the 2019 Conference Planning Committee, the Board of Directors, and the staff of the NCHC national headquarters, welcome to our 54th annual conference. We are very happy that you have taken this opportunity to learn, share, contribute, and grow with us as individuals and then extend this to not only your home institutions, but also to the larger realms of honors education and higher education. The conference topics of disruption and creativity are meant to challenge us to think, question, and act: all intrinsic to honors education globally. What better place to congregate and explore these concepts than New Orleans, a city that exemplifies them perfectly. With the diverse members of the honors community— students, faculty, administrators and administrative staff—the myriad of perspectives and experiences upon which we can draw, and the setting, we have something for everyone (from first-time attendees to veterans). Mindful that conference can be as exhausting as it is exhilarating (disruption and learning take energy!), we have added some opportunities to regain balance with networking receptions, Brain Breaks, morning yoga, and explorations of our amazing host city. We are excited that you have taken time from your busy schedules to spend the next few days with your extended honors family. -
Searchable Shulgin Pharmacology Notes, Book 9
The Shulgin Lab Books Pharmacology Lab Notes #9 (1986-1994) A Bit About This Document: While undertaking the work of investigating the chemistry and pharmacology of many varied psychoactive substances, Alexander “Sasha” Shulgin kept detailed notebooks. His documentation covered not only on his own personal research, but the research of friends and acquaintances. This book, the ninth of the “Pharmacology” series, represents mostly active dose work-ups of various substances. It covers the end of 1986 through half of 1994. The Creation of This Document: The project to undertake the transcribing of Shulgin’s Lab Books was started in 2008 by a team of volunteers and staff at Erowid, along with members of Team Shulgin. Various books were transcribed without a clear idea of how to present the information as a final product; eventually this format was chosen and a volunteer began work assembling the document. Each page was painstakingly transcribed from scanned images. All the hand-drawn “dirty pictures” (molecule drawings) and graphs were edited from the original scans and combined with drawn-in marks, outlines, and arrows to form this searchable PDF. Most of the names in this document have been redacted and pseudonyms put in their place. Names are presented as much as possible as they were in the original book, for example “Robert Thompson” is also “Robert”, “R.Thompson”, and “RT”. Initials are frequently used, and no two people share names or initials so the reader can keep track of who’s who. (ATS is Sasha and AP is Ann) Words highlighted in yellow are words that the transcription team could not decipher. -
Book 3, Shulgin Lab Books
The Shulgin Lab Books Pharmacology Lab Notes #3 (1980 - 1982) A Bit About This Document: While undertaking the work of investigating the chemistry and pharmacology of many varied psychoactive substances, Alexander “Sasha” Shulgin kept detailed notebooks. His documentation covered not only on his own personal research, but the research of friends and acquaintances. This book, the third of the “Pharmacology” series, represents mostly active dose work-ups of various substances and subjective responses by Shulgin and his research group. It covers the time frame of 1980 to 1982. The Creation of This Document: The project to undertake the transcribing of Shulgin’s Lab Books was started in 2008 by a team of volunteers and staff at Erowid, along with members of Team Shulgin. Various books were transcribed without a clear idea of how to present the information as a final product; eventually this format was chosen and a volunteer began work assembling the document. Each page was painstakingly transcribed from scanned images. All the hand-drawn “dirty pictures” (molecule drawings) and graphs were edited from the original scans and combined with drawn-in marks, outlines, and arrows to form this searchable PDF. Most of the names in this document have been redacted and pseudonyms put in their place. Names are presented as much as possible as they were in the original book, for example “Robert Thompson” is also “Robert”, “R.Thompson”, and “RT”. Initials are frequently used, and no two people share names or initials so the reader can keep track of who’s who. (ATS is Sasha and AP is Ann) Words highlighted in yellow are words that the transcription team could not decipher. -
Us 2019 / 0142851 A1
US 20190142851A1 ( 19) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2019 /0142851 A1 CHADEAYNE (43 ) Pub. Date : May 16 , 2019 ( 54 ) COMPOSITIONS COMPRISING A 2017 , provisional application No. 62/ 587, 410 , filed PSILOCYBIN DERIVATIVE AND A on Nov. 16 , 2017 , provisional application No . 62 /587 , CANNABINOID 395 , filed on Nov . 16 , 2017 . (71 ) Applicant: CaaMTech , LLC , Issaquah , WA (US ) Publication Classification (51 ) Int . Ci. ( 72 ) Inventor: Andrew R . CHADEAYNE , Issaquah , A61K 31/ 675 ( 2006 .01 ) WA (US ) A61K 31 / 4045 (2006 . 01 ) A61K 31/ 4406 ( 2006 .01 ) (21 ) Appl. No. : 16 / 192, 736 A61K 31/ 05 (2006 . 01) A61K 31 / 192 (2006 .01 ) ( 22 ) Filed : Nov . 15 , 2018 A61K 31 /353 ( 2006 . 01) (52 ) U . S . CI. Related U . S . Application Data CPC .. A61K 31/ 675 ( 2013 .01 ) ; A61K 31/ 4045 (60 ) Provisional application No . 62/ 613 , 360 , filed on Jan . (2013 . 01 ) ; A61K 31/ 353 (2013 .01 ) ; ACIK 3 , 2018 , provisional application No. 62 /609 , 115 , filed 31/ 05 (2013 . 01 ) ; A61K 31/ 192 (2013 . 01 ) ; on Dec . 21 , 2017 , provisional application No . 62/ 598 , A61K 31 /4406 ( 2013 . 01 ) 767, filed on Dec . 14 , 2017 , provisional application No . 62 /595 ,336 , filed on Dec . 6 , 2017 , provisional ( 57 ) ABSTRACT application No . 62 / 595 , 321 , filed on Dec . 6 , 2017 , This disclosure pertains to new compositions and methods provisional application No . 62 /593 ,021 , filed on Nov . comprising a psilocybin derivative . In one embodiment, the 30 , 2017 , provisional application No . 62 / 592, 320 , compositions disclosed herein are used for a method of filed on Nov . 29 , 2017 , provisional application No . -
Wild Self-Care Rethinking 'Risky' Health-Related Practices Among
Wild Self-Care Rethinking ‘Risky’ Health-related Practices Among Members of the Gay Community Simon Clay, BA (Hons), BSSc A thesis submitted for the degree of Doctor of Philosophy at the University of Otago, Dunedin August 2020 Abstract Gay and queer men tend to experience higher rates of mental health issues, STIs/HIV, suicide, substance dependency, and poor well-being than other demographics. Despite sustained public health efforts internationally, many of these issues continue to disproportionately affect members of the gay community. This thesis presents a new approach to the health issues gay and queer men face. It examines how ‘risky’ health-related practices including condomless sex and the use of illicit drugs might be legitimate ways of performing self-care and pursuing well- being. In order to address this aim, I conducted 16 interviews over a 12-month period in New Zealand and Australia using a constructionist grounded theory approach and a theoretical framework that draws upon the work of Judith Butler, Elizabeth Grosz, Michel Foucault, Homi Bhabha, Kane Race, Nikolas Rose, and Pierre Bourdieu. My participants and I explore a wide range of topics including the performative nature of sex and the notion of ‘play’, how pleasure and the emotional significance of sex might be related to self-care, the ways in which space might influence sexual practices and experiences, and to what extent having sex outside the home might be a form of self-care. I also cover safer sex practices and the experience of disease, how PrEP has radically changed the way gay men approach sex, the way drugs are bound up in self- care practices, and the relationships between self-care and community. -
Risky Beeswax: Artistic Responses to the Biopolitics of Hiv/Aids
RISKY BEESWAX: ARTISTIC RESPONSES TO THE BIOPOLITICS OF HIV/AIDS ANDREW ZEALLEY A DISSERTATION SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENVIRONMENTAL STUDIES YORK UNIVERSITY TORONTO, ONTARIO NovemBer 2020 © Andrew Zealley, 2020 ABstract In my dissertation, I examine risk in relation to HIV/AIDS and queer art and sex; and the proBlem that industrial mitigations of risk pose to sexually active queer men living with HIV, the kinds of sex they want, and the people they fuck in the era of AIDS industry. I explore this proBlem through four themes that emerged during my interviews with artists whose practices respond to AIDS and/or queer sex: 1) risking the personal; 2) (radical, ludic, and risky) sexual ecologies; 3) AIDS, its intersections and risky representations; and 4) the role of risk in art and artistic practice. I also use methods of participant comprehension, sensory ethnography, participant sensing, and artistic practice. The role of the interviews in helping me select the themes shaped my theoretical conversation and the three interventions that comprise my dissertation: audio, video, and written. Industrial mitigations of risk fetishize HIV status and HIV criminalization in ways that stigmatize queer and HIV-positive sexual practices, communities, and cultures. Risk— as idea and practice—is multidimensional and has Been important in HIV/AIDS art/activism since long Before AIDS industrialization. I talk aBout Biopolitics and respond to disciplinary- and bio- power through Foucault’s concept of pastoral power and his politics of aesthetic self-creation. -
Minutes of the September 10-11, 2003 NAEHSC
February 10-11, 2003 Minutes Of The NAEHSC - DERT Page 1 of 9 Department Of Health And Human Services National Institutes Of Health National Institute Of Environmental Health Sciences Minutes Of The National Advisory Environmental Health Sciences Council February 10-11, 2003 The National Advisory Environmental Health Sciences Council was convened for its one hundred seventh regular meeting on September 9, 2002, at 8:30 a.m., in Rodbell Auditorium, Building 101, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina. The meeting was open to the public from 8:30 a.m. until 5:00 p.m.. The meeting was closed for consideration of grant applications on September 10, from 9:30. a.m. until 12:00 p.m.. Dr. Kenneth Olden presided as Chair on September 9-10, 2002. Members Present: Daniel Baden, Ph.D. Deborah Brooks Charli Coon Joan Cranmer, Ph.D. Dale Eastman George Friedman-Jimenez, M.D. Michael Gallo, Ph.D. Bernard Goldstein, M.D. George Gray, Ph.D. Frederick P. Guengerich, Ph.D. Barbara Hulka, M.D., M.P.H. Phil Iannaccone, M.D., Ph.D. Peggy Shepard Martyn T. Smith, Ph.D. James G. Townsel, Ph.D. Members Absent: Deeohn Ferris, J.D. Daniel Nebert, Ph.D. Hon. Harriett M. Wieder Ex Officio Members Present: Kelley Brix, Ph.D. Eric L. Stephens Liaison Members Present: http://devinside-www.niehs.nih.gov/dert/council/2003/feb2003.htm 4/7/2010 4:01:38 PM February 10-11, 2003 Minutes Of The NAEHSC - DERT Page 2 of 9 Robert Spengler, Ph.D. -
Pihkal by Alexander Shulgin and Ann Shulgin
PiHKAL by Alexander Shulgin and Ann Shulgin 1 PiHKAL: The Chemical Story. Part 1 This is part 1 of 6 of the second half of PiHKAL: A Chemical Love Story, by Alexander Shulgin and Ann Shulgin. Please forgive any typos or misprints in this file; further, because of ASCII limitations, many of the typographical symbols in the original book could not be properly represented in these files. If you are seriously interested in the chemistry contained in these files, you should order a copy of the book PiHKAL. The book may be purchased for $22.95 ($18.95 + $4.00 postage and handling) from Transform Press, Box 13675, Berkeley, CA 94701. California residents please add $1.38 State sales tax. At the present time, restrictive laws are in force in the United States and it is very difficult for researchers to abide by the regulations which govern efforts to obtain legal approval to do work with these compounds in human beings.... No one who is lacking legal authorization should attempt the of any of the compounds described in these files, with the intent to give them to man. To do so is to risk legal action which might lead to the tragic ruination of a life. It should also be noted that any person anywhere who experiments on himself, or on another human being, with any of the drugs described herin, without being familiar with that drug's action and aware of the physical and/or mental disturbance or harm it might cause, is acting irresponsibly and immorally, whether or not he is doing so within the bounds of the law. -
Searchable Shulgin Pharmacology Lab Book 8
The Shulgin Lab Books Pharmacology Lab Notes #8 (1984-1986) A Bit About This Document: While undertaking the work of investigating the chemistry and pharmacology of many varied psychoactive substances, Alexander “Sasha” Shulgin kept detailed notebooks. His documentation covered not only on his own personal research, but the research of friends and acquaintances. This book, the eighth of the “Pharmacology” series, represents mostly subjective responses by Shulgin and his research group and active dose work-ups of various substances. It covers the end of 1984 through most of 1986. The Creation of This Document: The project to undertake the transcribing of Shulgin’s Lab Books was started in 2008 by a team of volunteers and staff at Erowid, along with members of Team Shulgin. Various books were transcribed without a clear idea of how to present the information as a final product; eventually this format was chosen and a volunteer began work assembling the document. Each page was painstakingly transcribed from scanned images. All the hand-drawn “dirty pictures” (molecule drawings) and graphs were edited from the original scans and combined with drawn-in marks, outlines, and arrows to form this searchable PDF. Most of the names in this document have been redacted and pseudonyms put in their place. Names are presented as much as possible as they were in the original book, for example “Robert Thompson” is also “Robert”, “R.Thompson”, and “RT”. Initials are frequently used, and no two people share names or initials so the reader can keep track of who’s who. (ATS is Sasha and AP is Ann) Words highlighted in yellow are words that the transcription team could not decipher. -
Exploring the (Sub)Cultural Dynamics of Gay, Bisexual
EXPLORING THE (SUB)CULTURAL DYNAMICS OF GAY, BISEXUAL AND QUEER MALE DRUG USE IN CYBERSPACE By Brian Jay Frederick Word Count: 75991 Thesis submitted to the University of Kent and Universität Hamburg in partial fulfilment for requirements for the degree of Doctor of Philosophy after following the Erasmus Mundus Doctoral Programme in Cultural and Global Criminology. EXPLORING THE (SUB)CULTURAL DYNAMICS OF GAY, BISEXUAL AND QUEER MALE DRUG USE IN CYBERSPACE By Brian Jay Frederick Word Count: 75991 Date of Submission: 19 April 2016 Thesis submitted to the University of Kent and Universität Hamburg in partial fulfilment for requirements for the degree of Doctor of Philosophy after following the Erasmus Mundus Doctoral Programme in Cultural and Global Criminology. University of Kent, School of Sociology, Social Policy and Social Research Universität Hamburg, Fakultät für Wirtschafts- und Sozialwissenschaften, Institut für Kriminologische Sozialforschung STATEMENT OF SUPERVISION This research project was co-supervised by Prof. Dr. Susanne Krasmann of the Institut für Kriminologische Sozialforschung at Universität Hamburg and Dr. Marian Duggan in the School of Sociology, Social Policy and Social Research at the University of Kent. ii ACKNOWLEDGEMENTS First, I would like to extend my heartfelt appreciation to my supervisors, Marian and Susanne, both of whom continually challenged and encouraged me to engage my critical and analytical sensibilities. I would also like to thank my DCGC program coordinators, Dr. Phil Carney and Dr. Bettina Paul, as well as my university ‘moms’, Kalliope Glezakou and Sarah: thank all for keeping me on track. I will be forever grateful to my ‘cousins’ Paula and Carlos. Your love and support helped to sustain me in a way that only family can. -
Pihkal: the Chemical Story, by Alexander and Ann Shulgin
The Vaults of Erowid : PiHKAL: The Chemical Story, by Alexander and Ann Shulgin The existence of Erowid.org is only possible through the support of visitors. Please become a member or make a donation today. Phenethylamines I Have Known And Loved: A Chemical Love Story By Alexander and Ann Shulgin phen-ethyl-amine \fen-'eth-al-a-,men\ n. [phenyl fr. F. phène, fr. Gk. phainein, to show (from its occurrence in illuminating gas)+ ethyl ( + yl) + amine fr. NL ammonia] 1: A naturally occurring compound found in both the animal and plant kingdoms. It is an endogenous component of the human brain. 2: Any of a series of compounds containing the phenethylamine skeleton, and modified by chemical constituents at appropriate positions in the molecule. COPYRIGHT NOTICE http://www.erowid.org/library/books_online/pihkal/pihkal.shtml (1 èç 8) [26.12.02 19:58:29] The Vaults of Erowid : PiHKAL: The Chemical Story, by Alexander and Ann Shulgin The Copyright for Part 1 of PiHKAL has been reserved in all forms and it may not be distributed. Part 2 of PiHKAL may be distributed for non-commerical reproduction provided that the introductory information, copyright notice, cautionary notice and ordering information remain attached. CAUTIONARY NOTE: READ BEFORE PROCEEDING At the present time, restrictive laws are in force in the United States and it is very difficult for researchers to abide by the regulations which govern efforts to obtain legal approval to do work with these compounds in human beings.... No one who is lacking legal authorization should attempt the synthesis of any of the compounds described in these files, with the intent to give them to man.