DOCSLIB.ORG

BMC Bioinformatics Biomed Central

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
BMC Bioinformatics Biomed Central BMC Bioinformatics BioMed Central Software Open Access An interactive visualization tool to explore the biophysical properties of amino acids and their contribution to substitution matrices Blazej Bulka1,2, Marie desJardins1 and Stephen J Freeland*2 Address: 1Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA and 2Department of Biological Sciences, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA Email: Blazej Bulka - [email protected]; Marie desJardins - [email protected]; Stephen J Freeland* - [email protected] * Corresponding author Published: 03 July 2006 Received: 12 December 2005 Accepted: 03 July 2006 BMC Bioinformatics 2006, 7:329 doi:10.1186/1471-2105-7-329 This article is available from: http://www.biomedcentral.com/1471-2105/7/329 © 2006 Bulka et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Quantitative descriptions of amino acid similarity, expressed as probabilistic models of evolutionary interchangeability, are central to many mainstream bioinformatic procedures such as sequence alignment, homology searching, and protein structural prediction. Here we present a web-based, user-friendly analysis tool that allows any researcher to quickly and easily visualize relationships between these bioinformatic metrics and to explore their relationships to underlying indices of amino acid molecular descriptors. Results: We demonstrate the three fundamental types of question that our software can address by taking as a specific example the connections between 49 measures of amino acid biophysical properties (e.g., size, charge and hydrophobicity), a generalized model of amino acid substitution (as represented by the PAM74-100 matrix), and the mutational distance that separates amino acids within the standard genetic code (i.e., the number of point mutations required for interconversion during protein evolution). We show that our software allows a user to recapture the insights from several key publications on these topics in just a few minutes. Conclusion: Our software facilitates rapid, interactive exploration of three interconnected topics: (i) the multidimensional molecular descriptors of the twenty proteinaceous amino acids, (ii) the correlation of these biophysical measurements with observed patterns of amino acid substitution, and (iii) the causal basis for differences between any two observed patterns of amino acid substitution. This software acts as an intuitive bioinformatic exploration tool that can guide more comprehensive statistical analyses relating to a diverse array of specific research questions. Background substitution matrices (such as the PAM and BLOSUM Molecular biology has made great progress in observing matrix families), which lie at the heart of mainstream bio- and quantifying the patterns by which amino acids informatics procedures, from algorithms that determine exchange for one another within protein sequences over whether [1] and how exactly [2] two proteins are homol- time. A key motivation here has been to create amino acid ogous, to those that predict protein tertiary structure by Page 1 of 9 (page number not for citation purposes) BMC Bioinformatics 2006, 7:329 http://www.biomedcentral.com/1471-2105/7/329 comparison with known folds [3]. However, these matri- a property that contains the term "hydrophobicity" in its ces represent generalized patterns of change "averaged" description.) Moreover, this comparison allows easy visu- across all proteins: although they typically encompass the alization of non-intuitive correlations (e.g., hydrophobic- idea that patterns of substitution will vary with evolution- ity and volume). The authors applied similarity-based ary distance, other systematic sources of variation are methods to their AAindex database to build a minimum overlooked. An increasing literature supports the idea that spanning tree: a graph-theoretic structure that connects dis- this generalization may compromise the sensitivity of crete elements together based on similarity, by minimiz- sequence comparison for various specialized subsets of ing the overall sum of the distances of the direct proteins (e.g., for particular protein families [4-8], or for connections. The result is a data structure in which ele- genomes that have evolved under unusual mutation ments are grouped together based on similarity (a detailed biases or selection regimes [9-11]). Thus a worthy chal- description and justification is given in the work of Tomii lenge is to seek the underlying ontology that can link indi- and Kanehisa who first applied this methodology to visu- vidually derived, specialized models of amino acid alizing amino acid similarity [23]). This minimum span- substitution into a common framework: if we can ulti- ning tree showed the underlying structure (clustering) for mately replace generalized patterns of observed change the 402 indices of their database. Since this time, numer- with a flexible, quantitative model of amino acid substitu- ous further indices and matrices have been developed: tion, then this offers significant potential to increase the some have been incorporated into updates of the AAin- sophistication of standard bioinformatics procedures. dex, while others remain isolated in the scientific litera- Such research may in fact be viewed as a subset of current ture (e.g., [10,25]). efforts to find a general, chemical ontology for bioactivity (e.g., [12-14]) where researchers face the same challenge In this context, we have developed free, user-friendly, of unifying diverse observations into a model that predicts publicly available web-based software that enables molecular interactions from first principles. researchers to repeat and extend the ideas of Nakai et al., [22] and Tomii and Kanehisa [23] using interactive data In this context, it has long been understood that amino visualization. We thus present the Amino Acid Explorer, a acid substitution matrices reflect a combination chemical web tool that facilitates quantitative exploration of simi- and evolutionary factors: most intuitively the biophysical larity between physiochemical properties of amino acids properties (known within chemical disciplines as "molec- and their evolutionary dynamics. Our tool allows users to ular descriptors") of the amino acids [15,16] and the explore the similarity between any of the 83 matrices and mutational distance of their encodings within the genetic any subset of the 494 indices housed by AAindex version code [5,17,18]. However, establishing accurate, quantita- 6.0, and to include any custom index or matrix (e.g., from tive connections between the outcomes of molecular evo- recent scientific literature or from unpublished research, lution and amino acids' molecular descriptors remains a as a matrix derived from an alignment of proteins in a par- complex issue under active research (e.g., [19-21]). ticular functional class, or an index derived by combining several physiochemical properties). We have embedded In this context, Nakai et al. created an innovative database, this analysis tool within a comprehensive web context: the AAindex [22], comprising both amino acid substitu- both a moderated user forum http://www.evolving tion matrices (20 × 20 matrices in which each element code.net/forum/viewforum.php?f=24 in which to discuss reflects some measure of the exchangeability of a pair of problems, findings or questions and an open wiki http:// amino acids) and amino acid indices (vectors of 20 ele- www.evolvingcode.net/ ments, each element being a value that describes some index.php?page=Amino_Acid_Indices in which the com- physiochemical property such as size or hydrophobicity, munity of those researching the interface of biochemistry for one of the twenty amino acids encoded by the stand- and protein evolution may contribute their knowledge. ard genetic code). In a later publication that expanded this database, Tomii and Kanehisa [23] suggested procedures Implementation for correlating any amino acid molecular descriptor with Our web tool, which may be accessed at http:// an observed exchange rate (e.g., substitution matrix) and www.evolvingcode.net:8080/aaindex/, comprises two for clustering indices together by similarity. major parts: one client side, one server side. The client side consists of the graphical interface that runs as a Java applet This latter technique of index clustering, is especially use- within a user's browser. The server side (residing on http:/ ful when exploring the relationship between indices, /www.evolvingcode.net), is a web application that per- given that properties of widespread interest have often forms all computations on the data, and is part of a larger been measured in many different ways by different computational infrastructure created around UMBC researchers. (For example, the latest version of the AAin- AAIndex database. Figure 1 shows an overview of our dex database [24] contains 29 different measurements of tool's architecture. Additionally, a short paragraph Page 2 of 9 (page number not for citation purposes) BMC Bioinformatics 2006, 7:329 http://www.biomedcentral.com/1471-2105/7/329 OverviewFigure 1 of Amino Acid Explorer Architecture
Load more

Recommended publications
  • Optimal Matching Distances Between Categorical Sequences: Distortion and Inferences by Permutation Juan P
    St. Cloud State University theRepository at St. Cloud State Culminating Projects in Applied Statistics Department of Mathematics and Statistics 12-2013 Optimal Matching Distances between Categorical Sequences: Distortion and Inferences by Permutation Juan P. Zuluaga Follow this and additional works at: https://repository.stcloudstate.edu/stat_etds Part of the Applied Statistics Commons Recommended Citation Zuluaga, Juan P., "Optimal Matching Distances between Categorical Sequences: Distortion and Inferences by Permutation" (2013). Culminating Projects in Applied Statistics. 8. https://repository.stcloudstate.edu/stat_etds/8 This Thesis is brought to you for free and open access by the Department of Mathematics and Statistics at theRepository at St. Cloud State. It has been accepted for inclusion in Culminating Projects in Applied Statistics by an authorized administrator of theRepository at St. Cloud State. For more information, please contact [email protected]. OPTIMAL MATCHING DISTANCES BETWEEN CATEGORICAL SEQUENCES: DISTORTION AND INFERENCES BY PERMUTATION by Juan P. Zuluaga B.A. Universidad de los Andes, Colombia, 1995 A Thesis Submitted to the Graduate Faculty of St. Cloud State University in Partial Fulfillment of the Requirements for the Degree Master of Science St. Cloud, Minnesota December, 2013 This thesis submitted by Juan P. Zuluaga in partial fulfillment of the requirements for the Degree of Master of Science at St. Cloud State University is hereby approved by the final evaluation committee. Chairperson Dean School of Graduate Studies OPTIMAL MATCHING DISTANCES BETWEEN CATEGORICAL SEQUENCES: DISTORTION AND INFERENCES BY PERMUTATION Juan P. Zuluaga Sequence data (an ordered set of categorical states) is a very common type of data in Social Sciences, Genetics and Computational Linguistics.
    [Show full text]
  • Sequence Motifs, Correlations and Structural Mapping of Evolutionary
    Talk overview • Sequence profiles – position specific scoring matrix • Psi-blast. Automated way to create and use sequence Sequence motifs, correlations profiles in similarity searches and structural mapping of • Sequence patterns and sequence logos evolutionary data • Bioinformatic tools which employ sequence profiles: PFAM BLOCKS PROSITE PRINTS InterPro • Correlated Mutations and structural insight • Mapping sequence data on structures: March 2011 Eran Eyal Conservations Correlations PSSM – position specific scoring matrix • A position-specific scoring matrix (PSSM) is a commonly used representation of motifs (patterns) in biological sequences • PSSM enables us to represent multiple sequence alignments as mathematical entities which we can work with. • PSSMs enables the scoring of multiple alignments with sequences, or other PSSMs. PSSM – position specific scoring matrix Assuming a string S of length n S = s1s2s3...sn If we want to score this string against our PSSM of length n (with n lines): n alignment _ score = m ∑ s j , j j=1 where m is the PSSM matrix and sj are the string elements. PSSM can also be incorporated to both dynamic programming algorithms and heuristic algorithms (like Psi-Blast). Sequence space PSI-BLAST • For a query sequence use Blast to find matching sequences. • Construct a multiple sequence alignment from the hits to find the common regions (consensus). • Use the “consensus” to search again the database, and get a new set of matching sequences • Repeat the process ! Sequence space Position-Specific-Iterated-BLAST • Intuition – substitution matrices should be specific to sites and not global. – Example: penalize alanine→glycine more in a helix •Idea – Use BLAST with high stringency to get a set of closely related sequences.
    [Show full text]
  • Computational Biology Lecture 8: Substitution Matrices Saad Mneimneh
    Computational Biology Lecture 8: Substitution matrices Saad Mneimneh As we have introduced last time, simple scoring schemes like +1 for a match, -1 for a mismatch and -2 for a gap are not justifiable biologically, especially for amino acid sequences (proteins). Instead, more elaborated scoring functions are used. These scores are usually obtained as a result of analyzing chemical properties and statistical data for amino acids and DNA sequences. For example, it is known that same size amino acids are more likely to be substituted by one another. Similarly, amino acids with same affinity to water are likely to serve the same purpose in some cases. On the other hand, some mutations are not acceptable (may lead to demise of the organism). PAM and BLOSUM matrices are amongst results of such analysis. We will see the techniques through which PAM and BLOSUM matrices are obtained. Substritution matrices Chemical properties of amino acids govern how the amino acids substitue one another. In principle, a substritution matrix s, where sij is used to score aligning character i with character j, should reflect the probability of two characters substituing one another. The question is how to build such a probability matrix that closely maps reality? Different strategies result in different matrices but the central idea is the same. If we go back to the concept of a high scoring segment pair, theory tells us that the alignment (ungapped) given by such a segment is governed by a limiting distribution such that ¸sij qij = pipje where: ² s is the subsitution matrix used ² qij is the probability of observing character i aligned with character j ² pi is the probability of occurrence of character i Therefore, 1 qij sij = ln ¸ pipj This formula for sij suggests a way to constrcut the matrix s.
    [Show full text]
  • Development of Novel Classical and Quantum Information Theory Based Methods for the Detection of Compensatory Mutations in Msas
    Development of novel Classical and Quantum Information Theory Based Methods for the Detection of Compensatory Mutations in MSAs Dissertation zur Erlangung des mathematisch-naturwissenschaftlichen Doktorgrades ”Doctor rerum naturalium” der Georg-August-Universität Göttingen im Promotionsprogramm PCS der Georg-August University School of Science (GAUSS) vorgelegt von Mehmet Gültas aus Kirikkale-Türkei Göttingen, 2013 Betreuungsausschuss Professor Dr. Stephan Waack, Institut für Informatik, Georg-August-Universität Göttingen. Professor Dr. Carsten Damm, Institut für Informatik, Georg-August-Universität Göttingen. Professor Dr. Edgar Wingender, Institut für Bioinformatik, Universitätsmedizin, Georg-August-Universität Göttingen. Mitglieder der Prüfungskommission Referent: Prof. Dr. Stephan Waack, Institut für Informatik, Georg-August-Universität Göttingen. Korreferent: Prof. Dr. Carsten Damm, Institut für Informatik, Georg-August-Universität Göttingen. Korreferent: Prof. Dr. Mario Stanke, Institut für Mathematik und Informatik, Ernst Moritz Arndt Universität Greifswald Weitere Mitglieder der Prüfungskommission Prof. Dr. Edgar Wingender, Institut für Bioinformatik, Universitätsmedizin, Georg-August-Universität Göttingen. Prof. Dr. Burkhard Morgenstern, Institut für Mikrobiologie und Genetik, Abteilung für Bioinformatik, Georg-August- Universität Göttingen. Prof. Dr. Dieter Hogrefe, Institut für Informatik, Georg-August-Universität Göttingen. Prof. Dr. Wolfgang May, Institut für Informatik, Georg-August-Universität Göttingen. Tag der mündlichen
    [Show full text]
  • 3D Representations of Amino Acids—Applications to Protein Sequence Comparison and Classification
    Computational and Structural Biotechnology Journal 11 (2014) 47–58 Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/csbj 3D representations of amino acids—applications to protein sequence comparison and classification Jie Li a, Patrice Koehl b,⁎ a Genome Center, University of California, Davis, 451 Health Sciences Drive, Davis, CA 95616, United States b Department of Computer Science and Genome Center, University of California, Davis, One Shields Ave, Davis, CA 95616, United States article info abstract Available online 6 September 2014 The amino acid sequence of a protein is the key to understanding its structure and ultimately its function in the cell. This paper addresses the fundamental issue of encoding amino acids in ways that the representation of such Keywords: a protein sequence facilitates the decoding of its information content. We show that a feature-based representa- Protein sequences tion in a three-dimensional (3D) space derived from amino acid substitution matrices provides an adequate Substitution matrices representation that can be used for direct comparison of protein sequences based on geometry. We measure Protein sequence classification the performance of such a representation in the context of the protein structural fold prediction problem. Fold recognition We compare the results of classifying different sets of proteins belonging to distinct structural folds against classifications of the same proteins obtained from sequence alone or directly from structural information. We find that sequence alone performs poorly as a structure classifier.Weshowincontrastthattheuseofthe three dimensional representation of the sequences significantly improves the classification accuracy. We conclude with a discussion of the current limitations of such a representation and with a description of potential improvements.
    [Show full text]
  • Assume an F84 Substitution Model with Nucleotide Frequ
    Exercise Sheet 5 Computational Phylogenetics Prof. D. Metzler Exercise 1: Assume an F84 substitution model with nucleotide frequencies (πA; πC ; πG; πT ) = (0:2; 0:3; 0:3; 0:2), a rate λ = 0:1 of “crosses” and a rate µ = 0:2 of “bullets” (see lecture). (a) Assume that the nucleotide at some site is A at time t. Calculate the probabilities that the nucleotide is A, C or G at time t + 0:2. (b) Assume the nucleotide distribution in a genomic region is (0:1; 0:2; 0:3; 0:4) at time t, but from this time on the genomic region evolves according to the model above. Calculate the expectation values for the nucleotide distributions at time points t + 0:2 and t + 2. Exercise 2: Calculate rate matrix for the nucleotide substution process for which the substitution matrix for time t is 0 1−e−t=10 21+9e−t=10−30e−t=5 1−e−t=10 1 PA!A(t) 10 70 5 B 2−2e−t=10 3−3et=10 3+7e−t=10−10e−t=5 C B PC!C (t) C S(t) = B 5 10 15 C ; B 14+6e−t=10−20e−t=5 1−e−t=10 1−e−t=10 C B PG!G(t) C @ 35 10 5 A 2−2e−t=10 3+7e−t=10−10e−t=5 3−3e−t=10 5 30 10 PT !T (t) where the diagonal entries PA!A(t), PC!C (t), PG!G(t) and PT !T (t) are the values that fulfill that each row sum is 1 in the matrix S(t).
    [Show full text]
  • Amino Acid Substitution Matrices from an Information Theoretic Perspective
    p J. Mol. Bd-(1991) 219, 555-565 Amino Acid Substitution Matrices from an , Information Theoretic Perspective Stephen F. Altschul National Center for Biotechnology Information National Library of Medicine National Institutes of Health Bethesda, MD 20894, U.S.S. (Received 1 October 1990; accepted 12 February 1991) Protein sequence alignments have become an important tool for molecular biologists. Local alignments are frequently constructed with the aid of a “substitution score matrix” that specifies a scorefor aligning each pair of amino acid residues. Over the years, manydifferent substitution matrices have been proposed, based on a wide variety of rationales. Statistical results, however, demonstrate that any such matrix is i.mplicitly a “log-odds” matrix, with a specific targetdistribution for aligned pairs of amino acid residues. Inthe light of information theory, itis possible to express the scores of a substitution matrix in bits and to see that different matrices are better adapted to different purposes. The most widely used matrix for protein sequence comparison has been the PAM-250 matrix. It is argued that for database searches the PAM-,I20 matrix generally is more appropriate, while for comparing two specific proteins with.suspecte4 homology the PAM-200 matrix is indicated. Examples discussed include the lipocalins, human a,B-glycoprotein, the cysticfibrosis transmembrane conductance regulator and the globins. Keywords: homology; sequence comparison; statistical significance; alignment algorithms; pattern recognition 2. Introduction . similarity measure (Smith & Waterman, 1981; Goad & Kanehisa, 1982; Sellers, 1984). This has the General methods for protein sequence comparison advantage of placing no a priori restrictions on the were introduced to molecular biology 20 years ago length of the local alignments sought.
    [Show full text]
  • Comparison Theorems for Splittings of M-Matrices in (Block) Hessenberg
    Comparison Theorems for Splittings of M-matrices in (block) Hessenberg Form Gemignani, Luca Dipartimento di Informatica Universit`adi Pisa [email protected] Poloni, Federico Dipartimento di Informatica Universit`adi Pisa [email protected] Abstract Some variants of the (block) Gauss–Seidel iteration for the solution of linear systems with M-matrices in (block) Hessenberg form are discussed. Comparison results for the asymptotic convergence rate of some regular splittings are derived: in particular, we prove that for a lower-Hessenberg M-matrix ρ(PGS ) ≥ ρ(PS) ≥ ρ(PAGS), where PGS , PS , PAGS are the iteration matrices of the Gauss–Seidel, staircase, and anti- Gauss–Seidel method. This is a result that does not seem to follow from classical comparison results, as these splittings are not directly comparable. It is shown that the concept of stair partitioning provides a powerful tool for the design of new variants that are suited for parallel computation. AMS classification: 65F15 1 Introduction Solving block Hessenberg systems is one of the key issues in numerical simula- tions of many scientific and engineering problems. Possibly singular M-matrix arXiv:2106.10492v1 [math.NA] 19 Jun 2021 linear systems in block Hessenberg form are found in finite difference or finite element methods for partial differential equations, Markov chains, production and growth models in economics, and linear complementarity problems in op- erational research [14, 2]. Finite difference or finite element discretizations of PDEs usually produce matrices which are banded or block banded (e.g., block tridiagonal or block pentadiagonal) [16]. Discrete-state models encountered in several applications such as modeling and analysis of communication and com- puter networks can be conveniently represented by a discrete/continuous time Markov chain [14].
    [Show full text]
  • Pathological Rate Matrices: from Primates to Pathogens
    UC San Diego UC San Diego Previously Published Works Title Pathological rate matrices: from primates to pathogens. Permalink https://escholarship.org/uc/item/5cm8723c Journal BMC bioinformatics, 9(1) ISSN 1471-2105 Authors Schranz, Harold W Yap, Von Bing Easteal, Simon et al. Publication Date 2008-12-19 DOI 10.1186/1471-2105-9-550 Peer reviewed eScholarship.org Powered by the California Digital Library University of California BMC Bioinformatics BioMed Central Research article Open Access Pathological rate matrices: from primates to pathogens Harold W Schranz1, Von Bing Yap2, Simon Easteal1, Rob Knight3 and Gavin A Huttley*1 Address: 1John Curtin School of Medical Research, The Australian National University, Canberra, ACT 0200, Australia, 2Department of Statistics and Applied Probability National University of Singapore, Kent Ridge, Singapore and 3Department of Chemistry & Biochemistry, University of Colorado, Boulder, CO, USA Email: Harold W Schranz - [email protected]; Von Bing Yap - [email protected]; Simon Easteal - [email protected]; Rob Knight - [email protected]; Gavin A Huttley* - [email protected] * Corresponding author Published: 19 December 2008 Received: 30 June 2008 Accepted: 19 December 2008 BMC Bioinformatics 2008, 9:550 doi:10.1186/1471-2105-9-550 This article is available from: http://www.biomedcentral.com/1471-2105/9/550 © 2008 Schranz et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    [Show full text]
  • 3D Deep Convolutional Neural Networks for Amino Acid Environment Similarity Analysis Wen Torng1 and Russ B
    Torng and Altman BMC Bioinformatics (2017) 18:302 DOI 10.1186/s12859-017-1702-0 METHODOLOGY ARTICLE Open Access 3D deep convolutional neural networks for amino acid environment similarity analysis Wen Torng1 and Russ B. Altman1,2* Abstract Background: Central to protein biology is the understanding of how structural elements give rise to observed function. The surfeit of protein structural data enables development of computational methods to systematically derive rules governing structural-functional relationships. However, performance of these methods depends critically on the choice of protein structural representation. Most current methods rely on features that are manually selected based on knowledge about protein structures. These are often general-purpose but not optimized for the specific application of interest. In this paper, we present a general framework that applies 3D convolutional neural network (3DCNN) technology to structure-based protein analysis. The framework automatically extracts task-specific features from the raw atom distribution, driven by supervised labels. As a pilot study, we use our network to analyze local protein microenvironments surrounding the 20 amino acids, and predict the amino acids most compatible with environments within a protein structure. To further validate the power of our method, we construct two amino acid substitution matrices from the prediction statistics and use them to predict effects of mutations in T4 lysozyme structures. Results: Our deep 3DCNN achieves a two-fold increase in prediction accuracy compared to models that employ conventional hand-engineered features and successfully recapitulates known information about similar and different microenvironments. Models built from our predictions and substitution matrices achieve an 85% accuracy predicting outcomes of the T4 lysozyme mutation variants.
    [Show full text]
  • Multiplicatively Closed Markov Models Must Form Lie Algebras
    Multiplicatively closed Markov models must form Lie algebras Jeremy G Sumner University of Tasmania, Australia [email protected] September 26, 2018 Abstract We prove that the probability substitution matrices obtained from a continuous-time Markov chain form a multiplicatively closed set if and only if the rate matrices associated to the chain form a linear space spanning a Lie algebra. The key original contribution we make is to overcome an obstruction, due to the presence of inequalities that are unavoidable in the probabilistic application, that prevents free manipulation of terms in the Baker-Campbell- Haursdorff formula. Keywords: Lie algebras; continuous-time Markov chains; semigroups; phylogenetics AMS classification codes: 17B45; 60J27 1 Background In this note we prove a result which makes explicit the requirement that a multiplicatively-closed Markov model must form a Lie algebra (definitions will be provided). We consider continuous-time Markov chains and work under the general assumption that a model is determined by specifying a subset of rate matrices (or rate generators). These models are used in a wide array of scientific modelling problems and have been previously studied in the context of Lie group theory by [8, 9]. Although the results given here are general, we are motivated primarily by applications to phylogenetics. Phylogenetics consists of the mathematical and statistical methods applied to reconstructing arXiv:1704.01418v2 [math.GR] 1 Sep 2017 evolutionary history from observed molecular sequences such as DNA [3]. Recent theoretical work [4, 12] has discussed the relevance of Lie groups and algebras to this applied area. The importance of Lie algebras to robust phylogenetic modelling has been demonstrated using simulation in [13], as well as on a diverse set of biological data sets in [15].
    [Show full text]
  • Metzlerian and Generalized Metzlerian Matrices: Some Properties and Economic Applications
    Journal of Mathematics Research; Vol. 7, No. 2; 2015 ISSN 1916-9795 E-ISSN 1916-9809 Published by Canadian Center of Science and Education Metzlerian and Generalized Metzlerian Matrices: Some Properties and Economic Applications Giorgio Giorgi1 & Cesare Zuccotti1 1 Department of Economics and Management, Via S. Felice, 5 - 27100 Pavia, Italy Correspondence: Giorgio Giorgi, Department of Economics and Management, Via S. Felice, 5 - 27100 Pavia, Italy. E-mail: [email protected] Received: February 19, 2015 Accepted: March 3, 2015 Online Published: March 25, 2015 doi:10.5539/jmr.v7n2p42 URL: http://dx.doi.org/10.5539/jmr.v7n2p42 Abstract In the first part of the paper we consider the main properties, with respect to stability and existence of solutions of multi-sectoral economic models, of Metzlerian and Morishima matrices. In the second part we introduce various generalized Metzlerian matrices, in order to enlarge the results of Ohyama (1972) in the study of stability and comparative statics for a Walrasian-type equlibrium model. Keywords: Metzlerian matrices, Morishima matrices, Walrasian system, stable matrices 1. Introduction Metzlerian matrices or Metzler matrices (in honor of the American economist L. A. Metzler (1913-1980)) are square (real) matrices in which all the off-diagonal elements are nonnegative: ai j = 0; 8i , j: Following the terminology of Fiedler and Ptak´ (1962) we can say that a square matrix A is a Metzlerian matrix if and only if −A 2 Z; where Z is the class of square matrices such that ai j 5 0; 8i , j: Therefore, the relevant properties of Matzlerian matrices can be derived from the “parallel” properties of the Z-matrices, i.
    [Show full text]