Anti-DKK3 (Full Length) Polyclonal Antibody (DPABH-06257) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-DKK3 (full length) polyclonal antibody (DPABH-06257) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Immunogen Recombinant full length mature protein, corresponding to amino acids 23-350 of Human Dkk3, Human cell expressed.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Protein A purified

Conjugate Unconjugated

Applications WB, ELISA

Format Liquid

Size 250 μg

Buffer pH: 7.00; Constituents: 5% Trehalose, 0.75% Glycine, 0.61% Tris. Note: 5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5%.

Preservative 0.05% Sodium Azide

Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol Dkk3

Synonyms DKK3; dickkopf 3 homolog (Xenopus laevis); dickkopf (Xenopus laevis) homolog 3; dickkopf- related protein 3; regulated in glioma; REIC; RIG; dkk-3; hDkk-3; dickkopf-3; RIG-like 5-6; RIG- like 7-1; dickkopf homolog 3;

Entrez Gene ID 27122

Protein Refseq NP_001018067

UniProt ID Q9UBP4

Chromosome Location 11p15.3

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]