Anti-DKK3 (full length) polyclonal antibody (DPABH-06257) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Immunogen Recombinant full length mature protein, corresponding to amino acids 23-350 of Human Dkk3, Human cell expressed. Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Protein A purified Conjugate Unconjugated Applications WB, ELISA Format Liquid Size 250 μg Buffer pH: 7.00; Constituents: 5% Trehalose, 0.75% Glycine, 0.61% Tris. Note: 5-10% trehalose is commonly used for freeze drying, and after reconstitution, the trehalose is mostly about 3-5%. Preservative 0.05% Sodium Azide Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. GENE INFORMATION 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Gene Name DKK3 dickkopf 3 homolog (Xenopus laevis) [ Homo sapiens ] Official Symbol Dkk3 Synonyms DKK3; dickkopf 3 homolog (Xenopus laevis); dickkopf (Xenopus laevis) homolog 3; dickkopf- related protein 3; regulated in glioma; REIC; RIG; dkk-3; hDkk-3; dickkopf-3; RIG-like 5-6; RIG- like 7-1; dickkopf homolog 3; Entrez Gene ID 27122 Protein Refseq NP_001018067 UniProt ID Q9UBP4 Chromosome Location 11p15.3 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.