powerful connections CHAIRMAN’S MESSAGE

I am delighted to present to you the 2017 Department of Medicine Annual Report entitled table of contents “Powerful Connections”. Connections that bridge our programs and people are so important to enhancing our missions of discovery, innovative patient care and mentorship. Connections are fun- damental to science and medicine. Across departments scientists connect scientific findings from bench to bedside and back with the goal of improving patient outcomes and developing better ther- apies, and our medical educators channel their knowledge to our trainees to enhance the learning environment and prepare them for their academic careers.

Chair’s message 1 Cardiology 14 Some examples from the last year include: • The appointment of four new administrative Clinically, the Department of Medicine continued Organization 2 Computational Biomedicine • The discovery that the onset of Celiac disease leaders, Matthew Sorrentino, MD as Vice Chair to impact patient care with new initiatives and and Biomedical Data Science 16 could be triggered by prior Reovirus infection for Clinical Operations, Steven White, MD as connections in the community, city, and region. Medicine by the Numbers 3 (Jabri) Associate Vice Chair for Appointments and This included the expansion of the Department’s Dermatology 18 Promotions, Anne Sperling, PhD as Associate clinical imprint at the University of Chicago Special Awards 4 • The preclinical development of novel approach- Vice Chair for Research and Julie White as Medicine’s new offsite practices in Orland Park Emergency Medicine 20 es to prostate cancer immunotherapy using a Executive Administrator and Chicago’s South Loop, at Ingalls Hospital Faculty Highlights 6 tyrosine kinase inhibitor to infiltrate and clear the as well as at satellite clinics in Indiana. The Endocrinology, Diabetes and Metabolism 22 tumor (Patnaik) • The creation of the new Section of Department also continues to lead efforts relating Research Programs Overview 8 Computational Biomedicine and Biomedical to the growth of emergency and trauma services at Gastroenterology, Hepatology • The expansion of the cellular and stem cell Data Science under the leadership of Robert UCM, and looks forward to the opening of the new Clinical Programs Overview 10 and Nutrition 24 transplant program with new targeted cellular Grossman, PhD and Andrey Rzhetsky, PhD Emergency Department in January, 2018 and the therapies, such as chimeric antigen receptor new Trauma Center in May, 2018. Education Programs Overview 12 General Internal Medicine 26 T-cell (CAR T) infusions, to improve the • The appointment of Esra Tasali, MD as responsiveness of cancer the director of the newly structured Sleep I am very proud of the Department of Medicine’s Genetic Medicine 28 Research Center contributions over the past year and the • Determining that helmet ventilation helps critically remarkable advances our faculty have achieved in Geriatrics and Palliative Medicine 30 ill patients breathe better (Patel, Hall, Kress) • The recognition of four of our faculty with patient care, research and education. I thank them named professorships from the University: for their dedication to our tripartite mission. Hematology/Oncology 32 • The creation of a new classification of common Thomas Gajewski, MD, PhD as the AbbVie diseases based on how often they occur among Foundation Professor; Robert Grossman, PhD Hospital Medicine 34 genetically-related individuals (Rzhetsky) as the Frederick H. Rawson Professor; Everett E. Vokes, MD Sonali Smith, MD as the Elwood V. Jensen John E. Ultmann Professor Infectious Diseases and Global Health 36 • The discovery that pre-existing Type 2 immune Professor and Nir Uriel, MD as the Louis Chairman, Department of Medicine activation protects against sepsis (Verhoef, Block Professor. Physician-in-Chief, University of Chicago Medicine & Biological Sciences Nephrology 38 Solway, Sperling) • National and international recognition for the Pulmonary/Critical Care 40 • New insights on improving clinical learning and work of many individuals including cancer patient care with the development of an online disparities and global health (Olufunmilayo Rheumatology 42 learning network to teach value based care, and Olopade, MD), bioethics (Mark Siegler, MD), improved strategies for inpatient handoffs (Arora) novel educational systems (Vineet Arora, MD), Residents and Fellows 44 immunotherapy (Thomas Gajewski, MD, PhD) Other noteworthy departmental highlights Select High Impact Publications 50 from this past year include: • National recognition as one of the safest • The appointment of two new section chiefs: hospitals in the country with the University of Committee Highlights 52 Vesna Petronic Rosic, MD as Chief, Section of Chicago Medicine garnering straight A’s for Dermatology, and Stacie Levine, MD as Chief, the 11th consecutive time by the prestigious Section of Geriatrics and Palliative Medicine and independent Leapfrog Group.

2017 Annual Report 1 department of medicine department of medicine organization by the numbers Chairman, Department of Medicine Everett E. Vokes, MD

2017 Executive Vice Chair of Appointments & Promotions Dorothy Hanck, PhD Committee: Vice Chair of Education John McConville, MD Vice Chair of Faculty Development Deborah Burnet, MD Vice Chair of Research Julian Solway, MD Vice Chair of Research (Basic) Bana Jabri, MD, PhD Associate Vice Chair – Appointments & Promotions Steven White, MD* Associate Vice Chair – Outpatients Operations Lisa Vinci, MD 15 303 Associate Vice Chair – Quality Andrew Davis, MD SUBSPECIALTY Associate Vice Chair – Research Anne Sperling, PhD* CLINICAL AND Associate Vice Chair – SECTIONS Urban Health Initiative/EMR & Transplant Edward Garrity, MD RESEARCH Executive Administrator Julie J. White RESEARCH FACULTY Associate Executive Administrator James Manthey ACTIVITY Section Cardiology James Liao, MD Chief Council: Computational Biomedicine & Biomedical Data Science Robert Grossman, PhD & Andrey Rzhetsky, PhD Dermatology Vesna Petronic-Rosic, MD Emergency Medicine Linda Druelinger, MD #23 NIH Funding Endocrinology, Diabetes & Metabolism Ronald Cohen, MD Gastroenterology, Hepatology & Nutrition David Rubin, MD General Medicine Deborah Burnet, MD #10 NIH Funding/Faculty Genetic Medicine Yoav Gilad, PhD Geriatrics & Palliative Medicine Stacie Levine, MD * CLINICAL $64M Total NIH Awards Hematology/Oncology Walter Stadler, MD Hospital Medicine David Meltzer, MD, PhD $104M Total Sponsored Infectious Diseases & Global Health David Pitrak, MD ACTIVITY Nephrology Arlene Chapman, MD Research Awards & Pulmonary/Critical Care Gokhan Mutlu, MD Rheumatology Marcus Clark, MD Clinical Trails Earnings Committee Diversity Committee Monica Vela, MD Chairs: Women’s Committee Helen Te, MD Julie Oyler, MD* 13,364 Admissions Chief 2017 Chief Residents: Nikhil Bassi, MD Residents Yasmin Karimi, MD 221,675 Outpatient Visits Cathryn Lee, MD Aaron Tannebaum, MD 329 63,507 Emergency Room Encounters 2018 Chief Residents Amrish Deshmukh, MD TRANSPLANT 1,118,608 RVUs Abdul Dia, MD Michelle Fletcher, MD CASES Erica MacKenzie, MD

Senior Budget and Finance Sunila Goel Management: Clinical Revenue and Billing Lisa Kogan Clinical Research Support Allison Buonamici Clinical Trials Financial Group Ashley Hoambrecker Human Resources (Academic) Sharon Frazier Human Resources (Staff) Chris Yaros 302 TRAINEES EDUCATIONAL Information Systems Max Marchevsky Research Administration Katie Pizer *new in FY 18 188 RESIDENTS ACTIVITY 114 SUBSPECIALTY FELLOWS 2 Department of Medicine special awards 2017

Elected Fellows of the Elected Members of the National Academy of Medicine American Academy of Arts and Sciences • Graeme Bell, PhD • Graeme Bell, PhD • Marshall Chin, MD++ • Olufunmilayo Olopade, MD • Robert Gibbons, PhD • David Meltzer, MD, PhD Elected Members of the Association of American Physicians • Olufunmilayo Olopade, MD • Michael A. Becker, MD • Kenneth Polonsky, MD • Eugene Chang, MD • Arlene Chapman, MD American College of Physicians Masters • Marcus Clark, MD • Holly Humphrey, MD • Fredric Coe, MD • Mark Siegler, MD • Alan Leff, MD • Bana Jabri, MD, PhD Department of Medicine Named Professorships department of medicine • James Liao, MD • Graeme Bell, PhD – Kovler Family Distinguished Professor • David Meltzer, MD, PhD • Eugene Chang, MD – Martin Boyer Professor • Olufunmilayo Olopade, MD • Marshall Chin, MD – Richard Parillo Family Professor in Healthcare Ethics awards • Kenneth Polonsky, MD • Thomas Gajewski, MD, PhD – Abbvie Foundation Professor ++ • Mark J. Ratain, MD • Robert Gibbons, PhD – Blum Riese Professor+ • Samuel Refetoff, MD • Harvey Golomb, MD – Lowell T. Coggeshall Professor Distinguished Service Awards Leif B. Sorensen, MD, Biological Sciences Division Awards • Angelo Scanu, MD • Robert Grossman, PhD – Frederick H. Rawson Professor+ • Joseph B. Kirsner, MD, PhD (2006) PhD Faculty Research Award • Distinguished Educator/Mentor – • Mark Siegler, MD • Holly Humphrey, MD – Ralph W Gerard Professor • Janet Rowley, MD (2007) • Suzanne Conzen, MD ( 2007) • Dorothy Hanck, PhD • Julian Solway, MD • James Liao, MD, PhD – Harold H. Hines, Jr. Professor • Louis Cohen, MD (2008) • Marisa Alegre, MD, PhD (2008) • Distinguished Clinicians: • Everett Vokes, MD • Michelle Le Beau, PhD – Arthur and Marian Edelstein Professor • Morton Arnsdorf, MD (2009) • Anne Sperling, MD (2008) • Senior Awards – • David Meltzer, MD, PhD – Fanny L. Pritzker Professor • Angelo Scanu, MD (2010) • Bana Jabri, MD, PhD (2009) Edward Garrity, MD and Wendy Stock, MD Elected Members of the • Olufunmilayo Olopade, MD – Walter L. Palmer Distinguished Service Professor • Keyoumars Soltani, MD (2011) • Eric Svensson, MD, PhD (2010) • Junior Award – Kamala Cotts, MD American Society for Clinical Investigation • Nanduri Prabhakar, PhD – Harold H. Hines, Jr. Professor • Jesse B. Hall, MD (2013) • Elbert Huang, MD (2011) • Distinguished Leader in Program Innovation • Marisa Alegre, MD, PhD • Kenneth Polonsky, MD – Richard T. Crane Distinguished Service Professor • Roy E. Weiss, MD, PhD (2014) • Patrick Wilson, PhD (2012) (Junior Awards) – Megan Huisingh-Scheetz, MD • Vineet Arora, MD+ • Mark Ratain, MD – Leon O. Jacobson Professor • Mark Siegler, MD (2014) • Konstantin Birukov, MD, PhD(2013) and Katherine Thompson, MD • Michael A. Becker, MD • Samuel Refetoff, MD – Frederick H. Rawson Professor • Samuel Refetoff, MD (2015) • Lucy Godley, MD, PhD (2013) • Distinguished Leader in Diversity and Inclusion : • Eugene Chang, MD • David Rubin, MD – The Joseph B. Kirsner Professor of Medicine • Eve Van Cauter, PhD (2016) • John Schneider, MD, MPH (2014) • Junior Award – Sonia Kupfer, MD • Marcus Clark, MD • Andrey Rzhetsky, PhD – Edna K. Papazian Professor+ • Roberto Lang, MD (2017) • Yu Ying He, PhD (2015) • Senior Award – Monica Vela, MD • Fredric Coe, MD • Christopher Shea, MD – Eugene J. Van Scott Professor • Dorothy Hanck, PhD (2017) • Esra Tasali, MD (2016) • Distinguished Leader in Community Service and • Suzanne Conzen, MD • Mark Siegler, MD – Lindy Bergman Distinguished Service Professor • Monica Peek, MD (2017) Advocacy(Junior Award) – Anna Volerman, MD • Elbert Huang, MD, MPH • Sonali Smith, MD – Elwood V. Jensen Professor++ Arthur H. Rubenstein, MD • Francis Strauss Mentorship Awards: • Thomas Gajewski, MD, PhD • Julian Solway, MD – Walter L. Palmer Distinguished Service Professor Mentorship Award Diversity Award: JP Kress, MD and Matthew Brady, PhD • Lucy Godley, MD, PhD • Walter Stadler, MD – Fred C Buffett Professor • Eugene B. Chang, MD (2007) • Monica Vela, MD (2010) • Harvey Golomb, MD • Wendy Stock, MD – Anjuli Seth Nayak Professor in Leukemia • Julian Solway, MD (2008) • David Howes, MD ( 2011) • James Liao, MD • Nir Uriel, MD – Louis Block Professor++ • Jesse Hall, MD (2009) • Blanca Camoretti-Mercado, PhD (2012) • Alan Leff, MD • Eve Van Cauter, PhD – Frederick H. Rawson Professor • Roberto Lang, MD (2010) • Minoli Perera, PhD (2013) • David Meltzer, MD, PhD • Everett Vokes, MD – John E. Ultmann Professor • Marshall Chin, MD (2010) • Monica Peek, MD, MPH (2014) • Gokhan Mutlu, MD • Irving Waxman, MD – Sara and Harold Lincoln Thompson Professor • Frederic Coe, MD (2011) • John Schneider, MD, MPH (2015) • Olufunmilayo Olopade, MD • Olufunmilayo Olopade, MD (2012) • James Woodruff, MD (2016) • Kenneth Polonsky, MD +new in FY 17 • Deborah Burnet, MD (2013) • Doriane Miller, MD (2017) • Samuel Refetoff, MD ++new in FY 18 • Mary Strek, MD (2014) • Angelo Scanu, MD • David Meltzer, MD, PhD (2015) • Julian Solway, MD • Wendy Stock, MD(2016) • Everett Vokes, MD • Graeme Bell, PhD (2017)

4 Department of Medicine 2017 Annual Report 5 anergy, and he characterized their mechanism of faculty highlights action. This work thus contributed to the identifi- cation of new therapeutic targets, all of which are being studied in clinical trials. The class of drugs farthest along is antibodies that block the PD-L1/ Sonali Smith, MD, Professor of Medicine (He- tion in 2001, she was appointed to the faculty as co-chair of the Center for International Blood and PD-1 axis, which help restore the function of T cells matology/Oncology) was named as the Elwood an instructor and successfully advanced through Marrow Transplant Research (CIBMTR) Lympho- already present at tumor sites. These discoveries V. Jensen Professor effective July 1, 2017. Dr. the academic ranks to assistant professor (2003), ma Working Group, and is currently studying the have contributed to FDA approval of anti-PD1 Smith is an internationally recognized expert in associate professor (2008) and was promoted role of stem cell transplantation for patients with antibodies for melanoma, and combination studies lymphoma therapeutics who has made outstand- to professor of medicine on March 1, 2017. high-risk follicular lymphoma. She serves on the with IDO inhibitors that are in Phase 3 clinical trials. ing contributions to the field through her clinical Editorial Board of the Journal of Clinical Oncology care, education and clinical research. As Director Dr. Smith currently serves in a number of lead- and Cancer, and serves as a member of the A major question being addressed by Dr. Gajewski of the Lymphoma Program for the University of ership positions with national and international National Cancer Institute’s Lymphoma Steering is why some patients fail to mount a spontaneous Chicago Medicine, Dr. Smith’s clinical research visibility. She is Vice-Chair of the Southwest Committee and on the Scientific Advisory Board anti-tumor T cell response. Dr. Gajewski found interests are in the development of new agents Oncology Group (SWOG) Lymphoma Committee for the Lymphoma Research Foundation (LRF). that it is tumor-derived DNA that is sensed by and rational combinations in the management where she oversees clinical trial development at innate immune cells, and that this happens via the of both treatment-naïve and relapsed/refrac- the cooperative group level and mentors faculty Dr. Smith is also a highly regarded and dedicated STING pathway. This led to the development of tory lymphomas. She has a special interest in across the country. She is the incoming chair educator and mentor. She recently co-chaired new drugs that can stimulate the STING pathway, the prognosis and biology of lymphoma, with of the Continuous Professional Development LRF 2017 Lymphoma Clinical Research Men- which also arenow in Phase I clinical studies. an ultimate aim to personalize approaches Committee for the American Society of Oncology toring Program and chaired the LRF’s Chicago based on individual risk factors. She is currently (ASCO) where she currently serves as the chair Rounds. She is an elected fellow of the Pritzker Dr. Gajewski also uncovered several mechanisms studying the role of stem cell transplantation of the ASCO Women in Oncology Subcommittee, School of Medicine’s Academy of Distinguished for why anti-tumor T cells fail to infiltrate the tumor in for patients with high-risk follicular lymphoma and as scientific track leader for Lymphoma/CLL. Medical Educators and a Senior Faculty Scholar some patients and thus resist immunotherapy. Using She is the incoming chair of ASCO’s Continuous in the Bucksbaum Institute for Clinical Excellence. THOMAS F. GAJEWSKI, MD, PHD genomic techniques, he identified tumor-intrinsic Dr. Smith completed her medical and internal med- Professional Development Committee. Dr. Smith She has chaired, organized and given lectures AbbVie Foundation Professor expression of β-catenin as a mechanism by which icine residency training at Northwestern University is an active member of the American Society of at the International John Ultmann Chicago some tumors actively exclude T cells from the tumor where she also served as chief resident. In 1998 Hematology and is currently co-editor of Hema- Lymphoma Symposium, now in its 15th year. As microenvironment. This work had led to a priori- she joined the Department of Medicine’s Hema- tology, the society’s annual education book and a scholar, she has published over 130 publica- tization of Wnt/β-catenin pathway inhibitors as a tology/Oncology fellowship program where she recently served as an elected representative to the tions and lectures extensively to peers and/or therapeutic approach to expand immunotherapy effi- served as chief fellow for one year. Upon comple- American College of Radiology. Dr. Smith is also patient audiences nationally and internationally. cacy. His current work is pursuing other oncogenes that can protect the tumor from the immune system and extending beyond melanoma to other cancers. SONALI SMITH, MD Thomas Gajewski, MD, PhD, Professor of Dr. Gajewski is responsible for several landmark Elwood V. Jensen Professor Pathology, Medicine, and the Ben May Depart- discoveries, each of which has created new Dr. Gajewski has also recently discovered that ment for Cancer Research was named as the paradigms and opened up new research dimen- certain components of the gut microbiota could inaugural AbbVie Foundation Professor. Dr. sions for his laboratory trainees and the field of stimulate the immune system to attack tumor Gajewski is an outstanding physician scientist cancer immunology as a whole. Early in his career, cells, in a landmark paper published in Science, who combines basic, translational and clinical Dr. Gajewski developed vaccines to boost T cells 2015. Recent work has identified a similar set research to develop novel cancer immunothera- responses against tumor antigens with the antici- of commensal bacteria associated with clinical pies. He has applied sophisticated technologies pation that it would drive cancer rejection. Although response to anti-PD-1 in patients, and he is to generate improved understanding of the tumor/ most patients developed immune responses working with a new biotech company to develop immune system interaction, and his current work against their tumors, only a subset of patients had probiotics that facilitate cancer immunotherapy. focused on identifying how tumors actively evade tumor shrinkage. This observation generated a new immunity is transforming the cancer field. hypothesis in the field—that the tumor itself might Dr. Gajewski is the recipient of numerous awards hold the key to resistance to host immunity. Using including the American Cancer Society Jules L. Dr. Gajewski received his PhD in immunology in new genomics technologies, he identified a set of Plangere Jr. Family Foundation Professorship in 1989 and his MD in 1991 from the University of genes expressed in the tumor microenvironment Cancer Immunotherapy. Most recently he was Chicago. He is a graduate of the Department’s that correlated with clinical outcome. Patients named as a recipient of an Outstanding Inves- Internal Medicine residency program and Hema- with clinical responses were those who, prior to tigator Award by the National Cancer Institute, tology/Oncology fellowship program. For two therapy, already displayed T cell infiltrates in the as a Giant in Cancer Care by OncLive, and years during his fellowship training, Dr. Gajewski tumor, suggesting that their immune system was received the William B. Coley award from the conducted research at the Ludwig Institute for initiating a response against the tumor, but these Cancer Research Institute. Dr. Gajewski also Cancer Research in Brussels, Belgium. In 1997 T cells appeared to be restrained by expression of serves as editor for Cancer Discovery and the he was appointed to the faculty as an assis- inhibitory pathways. Dr. Gajewski identified several Journal for Experimental Medicine, is chair of tant professor in the Departments of Pathology of these key negative signals, including PD-1/PD-L1 NIH study sections focused on cancer immu- and Medicine. He was promoted to associate interactions, the tryptophan-catabolizing enzyme notherapy grant review, and is past president professor in 2004, and professor in 2009. IDO, Foxp3+ regulatory cells, and intrinsic T cell of the Society for Immunotherapy of Cancer.

6 Department of Medicine 2017 Annual Report 7 Department of Medicine Programmatic Awards

• Marisa Alegre, MD, PhD+ – Infections • Michelle Le Beau, PhD – and the Stability of Transplantation University of Chicago Comprehensive Tolerance (P01) Cancer Center (P30)

• Graeme Bell, PhD – Diabetes • Nanduri Prabhakar, PhD – Drs. Bana Jabri, Research Training Center (P60) Integrative Consequences of Julian Solway, and Hypoxia (P01) Anne Sperling • Eugene Chang, MD – Inflammatory Bowel Disease and Mucosal Inflammation, • Elaine Worcester, MD+ – Immunology, and Microbiology of the G.I. Pathogenesis of Calcium Neph- Tract (P30) rolithiasis (P01)

• Marshall Chin, MD & Monica Peek, MD – research programs Chicago Center for Diabetes Translation Research (P30) overview In FY 17 the Department of Medicine’s research port- * folio totaled nearly $64M in federal awards, $29M in Select High Impact Awards industry funded grants/clinical trial earnings and al- most $11M in other non-federal awards. The Depart- • Marc Bissonnette, MD+ – • Nanduri Prabhakar, PhD – The Department of Medicine has a long tradition of conducting original and rigorous biomedical ment is home to several NIH funded program or cen- Development of 5HMC and 5MC Therapeutic Targeting of Carotid Body ter grants as well as 10 T series and 3 K12 training Biomarkers in Cell-Free Circulating Chemoreflex for Sleep Disordered Breathing and clinical research of fundamental significance. Over the past year, Medicine investigators con- programs. Other federal awards include 51 R series DNA for Sensitive Colon Cancer (UH3) and 18 K (career development) grants. The Depart- Detection and Prognosis (U01)+ tinued to connect bench research to clinical practice with many seminal discoveries. ment’s goal to train the next generation of academic • Andrey Rzhetsky, PhD – physicians scientists successfully yielded 3 new NIH • Marcus Clark, MD – Big Machine Science (DARPA) For example, Medicine scientists discovered that tional or interdepartmental programs, including human health and disease. Currently 47 faculty from individual career development (K) awards and 2 fel- Medical Scientist Training Program the onset of Celiac disease could be triggered the Comprehensive Cancer Center, Institute for across 10 sections in the Department are actively lowships during the past year as well as the renewal • Renslow Scherer, MD – by prior Reovirus infection (Jabri, et al., Science Translational Medicine, Institute for Integrative Physi- pursuing microbiome research. In other research of the Endocrinology Training Grant (Graeme Bell, • David Ehrmann, MD & WUMER Project 2017); created a new classification of common ology, Center for Personalized Therapeutics, the highlights, the Section of Genetic Medicine led by PhD, and Samuel Refetoff, MD, PIs). The Depart- Eve Van Cauter, PhD – diseases based on how often they occur among Chronic Disease Center, Center for HIV Elimina- Yoav Gilad, PhD, established single cell genom- ment conducted more than 1,805 clinical research Enhancement of Beta Cell Function • Anne Sperling, PhD – genetically-related individuals (Rzhetsky, Nature tion, and the Center for Data Intensive Science. ic services for the Department and Biological studies, including 587 industry-funded studies. with Pharmacologic and Sleep Apnea Treat- Functional Genomics of IL-33 Expression and Genetics, 2017); and discovered that Amish Sciences Division, and Anne Sperling, PhD, was ment (U01) Asthma Risk environment provides protection against asthma by New research initiatives in FY 17 included the appointed as Associate Vice Chair for Research The third annual Janet D. Rowley Research Day was engaging and shaping the innate immune response. creation of the Section of Computational Biomedi- to oversee the development and mentoring of held on March 6, 2017. The day commenced with an • Robert Grossman, PhD – • Julian Solway, MD+ – (Hrusch, Sperling, et al., New England Journal of cine and Biomedical Data Science (CBBDS) under research focused senior fellows and junior faculty. outstanding talk by Jeffrey Bluestone, PhD, the A.W. The Open Genomic Data Commons (OGDC) ITM 2.0 Advancing Translational Science in Medicine, 2016). Recognition of the Department’s the co-leadership of Robert L. Grossman, PhD, and and Mary Margaret Clausen Distinguished Professor Metropolitan Chicago (UL1) research programs is indicated by the consistent Andrey Rzhetsky, PhD. CBBDS provides an intel- Also in FY 17 the Department created a Re- and Director of the Hormone Research Institute at • Karen Kim, MD – ranking among the top 25 NIH-funded departments lectual home for faculty whose research interests search Advisory Committee (RAC), co-directed the University of California at San Francisco. Best Cook County Colon Cancer Alliance to Reig- *Represents $800K+ in annual total cost funding of medicine by US News and World Report. encompass computational biomedicine, biomedical by Research Vice Chairs, Julian Solway, MD, and abstract winners in the faculty category include Kristin nite and Enhance Screening (CDC) data science and biomedical informatics. Also Bana Jabri, MD, PhD, to develop a short and long Bergsland, PhD, Joyce Tang, MD, Amy Gurlanick, MD +New/competitively renewed in FY 18 The Department has internationally recognized in FY 17, Esra Tasali, MD, was appointed as the term research strategic plan for the Department and Willard Sharp, MD, PhD and Alexandria Bobe, • Yusuke Nakamura, MD, PhD – expertise in multiple domains including cancer, director of the newly structured Sleep Research that optimizes research excellence and enhances MS, Julia Caldwell, PhD, Kristen Whitaker, MD and Development of New Targeted Cancer Thera- A list of the DOM’s FY 17 microbiome medicine, hypoxia, genetics, dispari- Center. Dr. Tasali is an internationally recognized interdisciplinary research in collaboration with BSD Toru Shimizu, MD, PhD in the trainee category. pies (OncoTherapy Science) Total Sponsored Research Awards can ties/outcomes research, health services, autoim- expert in the study of sleep disturbances as they and the University at large. Accomplishments to be found at: medicine.uchicago.edu munity and transplantation, mucosal immunology, relate to metabolic and endocrine abnormalities. As date includes the organization and participation in Recognizing the research success of an out- • David Pitrak, MD – endothelial biology, and critical care. The Depart- director, Dr. Tasali is developing cross-departmental two research retreats to define the Department’s standing mid-level scientist, the Department University of Chicago Program for Expanded ment’s investigative programs are diverse and span collaborations to strengthen the sleep program. thematic research priorities and launching of a selected Monica Peek, MD, Associate Professor Human Immunodeficiency Testing for Dispro- the translational research spectrum with import- Relating to microbiome research, the Department nationwide search for research focused translation- of Medicine, as the recipient of the 2017 Leif B. portionately Affected Populations in Healthcare ant connections across the Biological Sciences created the Microbiome Medicine Program (MMP) al scientists. The Department is also augmenting Sorensen, MD, PhD, Faculty Research Award for Settings in Chicago (CDPH) Division, other University units and externally at under the co-direction of Eugene Chang, MD, and the career development of junior faculty through her pioneering research on shared decision-mak- Argonne National Laboratory and the Marine Marisa Alegre, MD, PhD, to advance the tools and the efforts of the newly formed Mentorship/Reten- ing among African-Americans with diabetes and Biological Laboratory. Institutionally, Medicine practice of precision medicine through discovery tion/Leadership Committee led by the Vice Chair effective community engagement to improve faculty lead several multidisciplinary, intersec- and knowledge of microbiomes and their role in for Faculty Development, Deborah Burnet, MD. diabetes outcomes and reduce health disparities.

8 Department of Medicine 2017 Annual Report 9 Dr. Matthew Sorrentino

Park and South Loop include clinical programs in cardiology, primary care, oncology, gastroenterol- ogy, diabetes and pulmonology, and complement the five ambulatory care centers run by Ingalls clinical programs throughout the South and Southwest suburbs.

The Department’s Clinical Operations Committee overview (Matthew Sorrentino, MD - Director) launched many new initiatives in FY 17 to enhance clinical productivity and provider, housestaff and patient Dr. Peter Reidell with internal satisfaction, including refining inpatient service medicine resdients models, developing formal educational curriculum The Department of Medicine’s clinical programs demonstrate excellence across a broad spectrum for cardiac and hematology/oncology services Dr. Berry assesses a and enhancing new patient access. Wait times of subspecialty patient care services for the treatment of highly complex diseases. In FY 17, the patient in CCP clinic for new and return patients have been signifi- cantly reduced by initiatives that give patients Department’s clinical innovators continued to impact patient care with a multitude of groundbreak- more immediate access to ambulatory care. Within the area of clinical research, many of ing therapies and technologies. Many examples exist such as connecting research to the develop- the Department’s dedicated clinicians produce practice changing clinical research. The De- ment of targeted therapeutic and immunotherapeutic strategies to improve the responsiveness of partment has a robust and highly productive therapeutic clinical trials program and broad cancer, linking machine learning methods to cardiac arrest predictions, and associating data min- On the inpatient side, admissions increased the United States evaluating this new technology expertise in drug development, especially targeted by 3.6% to approximately 13,360. The Depart- in patients suffering from ventricular tachycardia. therapies. In FY 17 the Department conduct- ing techniques to identify patients at high risk of sepsis, as well as helmet ventilation to help criti- ment’s on-site outpatient subspecialty practices ed more than 1,800 clinical research studies, and primary care visits totaled 194,000 while With over 63,500 visits in FY 17, the Emergency including nearly 600 industry-funded studies. cally ill patients breathe better. In addition, over the past year the Department expanded its clinical the offsite subspecialty practices at 150 E. Department (ED) focused efforts on preparing Huron and at South Shore Senior Health Center for the opening of the new emergency room on In FY 17 the University of Chicago Medicine imprint in the city and the region with significant presence at the University of Chicago Medicine’s recorded 15,724 and 8,035 visits, respectively. January 8, 2018. With leadership from Thomas continued to be recognized as one of the safest GI procedure volumes totaled nearly 18,000 Spiegel, MD, many operational improvements hospitals in the country for the 11th consecutive (UCM) new offsite practices in Orland Park and in the Chicago’s South Loop, at Ingalls Hospital, with the largest increase in interventional were achieved in FY 17 including reduction in time by the prestigious and independent Leapfrog procedures (up 6%). In FY 17, transplant cases length of stay and left without being seen. Soon Group. In Leapfrog’s semi-annual Hospital Safety as well as at satellite clinics in Indiana. totaled 329 representing an increase of over after the new EM opens the UCM will launch Score, UCM garnered “Straight A’s” designation 14% with bone marrow transplants accounting Level 1 adult trauma services in spring 2018. The for its consistency in delivering the highest level of The Department of Medicine is an institutional leader as measured by faculty count and physician for about half (164) of the volume. The big- Center for Liver Diseases was expanded with the quality and protecting its patients from prevent- gest increases were seen in liver transplants recruitments of Michael Charlton, MD (Director) able medical errors, injuries and infections while work RVUs generation, and a major contributor to the overall success of the University of Chicago (up 58%) and heart transplants ( up 34%). Anjana Pillai, MD and Sonali Paul, MD, and the in the hospital. Only 63 out of 2,600 hospitals launch of a multidisciplinary Liver Tumor Clinic nationwide have earned continuous top marks in Medicine (UCM). In FY 17, Medicine clinical faculty continued to perform at a strong level by gen- In FY 17 the University of Chicago Medicine that includes coordinated visits with hepatolo- the twice-a-year review by The Leapfrog Group. and the Heart and Vascular Center opened a gy, surgery, oncology and other specialties. erating nearly 1.12 million physician work RVUs (wRVUs), representing a significant portion of the new 1,500 square feet Arrhythmia Technology In FY 18 the Department looks forward to the Suite, which employs state-of-the-art magnetic Also noteworthy in FY 17 was the opening of two opening of the new Emergency Department and clinical practice activity of the entire UCM and a 1.3% increase over last fiscal year. technology for cardiac electrophysiological (EP) offsite ambulatory practices with significant clinical Trauma Center as well as working with UCM mapping and ablation. Under the direction of representation from the Department of Medicine. leadership to finalize plans for the conversion of Roderick Tung, MD the EP lab is the lead site in The UCM’s Centers for Advanced Care at Orland Mitchell Hospital into a 188 bed Cancer Hospital.

10 Department of Medicine 2017 Annual Report 11 Dr. Vokes with Dr. Poston at the 2017 Medicine Awards Day educational programs Division of Biological Sciences Awards: • Francis Strauss Mentorship Award – overview Matthew Brady, PhD and JP Kress, MD Dr. McConville with the Resident Research Day Abstract Winners Department of Medicine Awards: • Preclinical Teacher of the Year – the clinical dermatology elective rotation. The Der- three graduates matched at competitive fellowships Peter O’Donnell, MD The Department of Medicine is deeply committed to the education and training of skilled physician matopathology Fellowship Program, led by Vesna in allergy-immunology, endocrinology, and palliative • Clinical Teacher of the Year – Jeanne Farnan, MD Petronic - Rosic,MD, continues to attract derma- care at University of Michigan, Mayo Clinic and Van- • Postgraduate Teaching – Jason Poston, MD scientists and leaders bound for careers in academic medicine in an environment supporting cul- tology and pathology trained graduates seeking derbilt respectively and the other graduate is cur- • Arthur Rubenstein, MD Mentorship Award– specialty training in dermatopathology, with over 40 rently serving as Pediatric Chief Resident at UCM. Graeme Bell, PhD tural diversity and patient safety. Under the leadership of John McConville, MD, the Department’s applicants for one training position in FY 17. In con- Medicine Resident Teaching Awards: tinuing medical education, the Section hosted the Honors: The Department of Medicine’s extraor- o JP Kress, MD educational programs continue to successfully prepare trainees for careers in clinical medicine, annual Chicago Dermatological Society Educational dinary pool of talented educators continue to be o Nitasha Sarswat, MD Conference in December, 2016. This event included recognized for their excellence in undergraduate o Marion Hofman-Bowman, MD, PhD teaching, and biomedical research. the Allen Lorincz Memorial Lecture as well as the and graduate medical education both institution- o Ted Naureckas, MD Maria Medenica Dermatopathology Lecture, both ally and nationally. In FY 17, Drs. Jeanne Farnan, • Emergency Medicine Resident Awards: Within the Internal Medicine Residency (IMR) recruited four outstanding MD/PhDs to continue ars training. Additionally, the Section of Emergency of which were presented by Victor G. Prieto, MD, Philip Hoffman, and Scott Stern were recognized o Outstanding Emergency Medicine Faculty Program, 85% of the graduates pursue subspe- their residency and fellowship training in cardi- Medicine continued to recruit talented and com- PhD, Chair of the Department of Pathology at the as “Favorite Faculty” by the Pritzker graduating Member Clinical Teaching – David Harter, MD cialty training. The 2016 fellowship match success- ology, gastroenterology, hematology/oncology petitive medical education scholars to participate University of Texas MD Anderson Cancer Center. class for the seventh time is as many years. Dr. o Outstanding Emergency Medicine Faculty fully matched 36 residents into many of the most and infectious diseases in the Department. in the Medical Education Fellowship (James Ahn, Dr. Prieto spoke on the updated recommendations Farnan was also selected as the 2017 Clinical Member Mentorship – Naveet Cheema, MD competitive and premier fellowship programs in the MD - Director). This year the Section welcomed for melanoma reporting and the use of special Teacher of the Year by the internal medicine • Resident Research Day 2017 country, including 11 who continued their training at With leadership from Christine Babcock, MD, the former resident and Pritzker graduate Paul Kukulski, studies in the diagnosis of melanocytic lesions. residents. Graeme Bell, PhD was awarded the o Most Outstanding Research Poster – the University of Chicago. Cardiology was the most Emergency Medicine (EM) Residency Program con- MD as a two-year Medical Education Scholar. From Department’s Arthur Rubenstein Mentorship Priya Mehta, MD popular fellowship choice with 8 house staff match- tinued to expand its robust education platform fo- a research standpoint, curricular, simulation and In FY 17 the Medicine/Pediatrics Residency Award and Naveet Cheema, MD was the recipient o Housestaff Choice Award – Linda Lee, MD ing to outstanding programs across the country. cusing on a cutting edge didactic curriculum, medi- procedure-based research has been published and Program led by Rita Rossi-Foulkes, MD had another of the Emergency Medicine Mentorship Award. o Most Outstanding Clinical Vignette – Other frequent fellowship choices included gastro- cal education research, and simulation opportunities presented nationally. For example, Eric Shappell, successful match, recruiting 4 top ranked candi- Rita Rossi-Foulkes, MD was awarded the first Parita Patel, MD enterology (6), pulmonary/critical care (4), geriatrics for residents. In FY 17, the didactic curriculum was MD created an innovative web-based “flipped class- dates into 4 open slots. Strong faculty mentorship by University of Chicago Medicine-Biological Sci- (4), hematology/oncology (3) and palliative care (3). expanded to include diversity, quality improvement, room” curriculum for EM interns which is currently in the internal medicine, pediatric and medicine – ences Division Program Director of Year Award. Pritzker School of Medicine and a wellness series to ensure a well-balanced use by many programs nationally and internationally. pediatrics faculty along with rigorous training in both Education and Mentorship Awards: In FY 17, Shannon Martin, MD and Amber curriculum for the EM learners as well as a formal disciplines and the diverse patient population attract The Department is the home to several nationally • Favorite Faculty Award Winners: Pincavage, MD led the IMR Intern Selection ultrasound education for both the EM residents The Section of Dermatology pursues its mission of top applicants. Candidates are also attracted to recognized medical research training programs, o Adam Cifu, MD Committee. An outstanding PGY 1 class of 41 and the Pritzker School of Medicine students. The contributing to the field of academic dermatology the LUCENT primary care track and the MedPeds including 10 NIH-funded training (T32) grants o Keme Carter, MD, interns (10% URM’s) was successfully recruited education platform was also expanded to include and providing excellent resident education and PATHways (Program for Adolescent and Adult in cardiology, adult and pediatric endocrinology, o Jeanne Farnan, MD, from almost 1900 applicants. IMR applicants from Emergency Medicine Services education and Di- training. The Dermatology Residency Program led Transition to Health) program to improve care of ad- oncology, respiratory biology, digestive diseases, o Philip Hoffman, MD, some of the most prestigious medical schools saster Medicine training under the direction of Katie by Sarah Stein, MD, received over 500 applications olescents and young adults with chronic childhood social science and aging, mental health, clinical o Mindy Schwartz, MD continue to be attracted to the rigorous clinical Tataris, MD. Medical education continues to be in 2016, and successfully matched outstanding conditions. In FY 17, two graduating medicine-pedi- therapeutics, sleep, as well as the medical scien- o Scott Stern, MD, training, diverse patient population and outstand- strength and a focus in the EM program, with a total candidates to each of the three available positions. atrics residents completed the MacLean Fellowship tist training program. The Department also holds ing faculty mentorship. Led by James Liao, MD, of five Emergency Medicine residents having com- Additionally, the Section hosted numerous Pritzker in Medical Ethics and one resident completed the three NIH (K12) Career Development Grants in the Physician Scientist Development Program pleted University of Chicago MERITS/GME Schol- medical students and visiting medical students on MERITS Medical Education Fellowship. In addition oncology, lung disease and outcomes research.

12 Department of Medicine 2017 Annual Report 13 implants (88.5% survival rate to date). The scripts in FY 17. New funding include two new Professors: Gene Kim, MD AHF program also successfully implanted the American Heart Association grants to Drs. Liao James Liao, MD (Chief) Hemal Nayak, MD first ever ambulatory intra-aortic balloon pump and Tabit to study RGS5 as a novel therapeutic Jafar Al-Sadir, MD (Emeritus) Cevher Ozcan, MD iVAS as part of a clinical trial and 7 patients target for ischemic stroke and to investigate the Louis Cohen, MD (Emeritus) Jonathan Paul, MD were enrolled in the CardioMEMs program. molecular mechanisms of non-surgical bleeding Jeanne DeCara, MD Tamar Polonsky, MD in patients with continuous-flow left ventricular Dorothy Hanck, PhD Jayant Raikhelkar, MD The Cardiovascular Imaging Center (Roberto assist devices, respectively. Tamar Polonsky, MD Roberto Lang, MD Nitasha Sarswat, MD Lang, MD–Director) is recognized for pioneer- received an award from the Patient Centered Victor Mor-Avi, PhD* Gabriel Sayer, MD ing many of the cardiac and vascular imaging Outcomes Research Institute (PCORI)/Chi- Matthew Sorrentino, MD Corey Tabit, MD+ techniques used around the world. In FY 17, cago Community Trust to assess the benefits Kirk Spencer, MD Gaurav Upadhyay, MD Dr. James K. Liao the Imaging Center realized growth across all and long term effectiveness of aspirin dosing. Nir Uriel, MD Rongxue Wu, PhD* domains including echocardiograms, cardi- Parker Ward, MD ac CTs, cardiac MRIs, and nuclear studies In the educational realm, the Section is home Instructor: over last year. The Interventional Cardiology/ to one of the oldest National Institutes of Associate Professors: Wenndy Hernandez, PhD+ Cardiac Catheterization Program (Sandeep Health-funded cardiovascular research pro- Marion Hofmann-Bowman, MD, PhD Nathan, MD, and Atman Shah, MD–Co-Di- grams in the nation as well as four ACGME Sandeep Nathan, MD Clinical Associates: section of rectors) also experienced growth in coronary accredited fellowship training programs. The Amit Patel, MD Marlon Everett, MD angiography and coronary interventions. In FY 7th annual Morton F. Arnsdorf Cardiovascular Atman Shah, MD Ankur Shah, MD 17, the Cath Lab launched two new clinical Sciences Research Day, co-chaired by Francis Roderick Tung, MD Evan Stein, MD initiatives: the MitraClip (percutaneous edge Alenghat, MD, PhD, and Marion Hofmann-Bow- to edge mitral repair) Clinical Program and the man, MD, PhD, featured nearly 106 presen- Assistant Professors: Part Time cardiology Pulmonary Embolism Response Team Program. tations by faculty and trainees. In FY 17, Dr. Karima Addetia, MD Michael Davidson, MD Hofmann-Bowman and Nitasha Sarswat, MD, Francis Alenghat, MD, PhD The Section of Cardiology’s research programs were recognized for excellence in teaching by Zaid Aziz, MD Section Administrator are robust with over 200 published manu- the Department of Medicine Residency Program. Andrew Beaser, MD+ Nishq Mody (interim) a clinical electrophysiologist and a physician John Blair, MD Under the leadership of James K. Liao, MD, the Section of scientist, who currently holds a NIH K award Michael Broman, MD, PhD *Research Appointee Track Faculty Cardiology enjoyed success across its clinical, research and investigating mitochondrial mechanisms of atrial Sara Kalantari, MD+ + new FY 18 faculty fibrillation and the role of cellular energetics educational programs in FY 17. This includes the expansion of and metabolism in mechanisms of arrhythmias. Dr. Tabit examines the effects of mechanical Impactful Accomplishments and Discoveries: the clinical programs with the opening of the new Arrhythmia • Nir Uriel, MD — Named as the Louis Block Endowed Professor and circulatory support on the blood vessels. • Roberto Lang, MD — Recipient of 2017 Department of Medi- selected as the national PI of MOMENTUM 3 Study and Associate Editor Technology Suite and the establishment of important connections cine Distinguished Service Award, the 2017 Gold Medal Award of Circulation Heart Failure In FY 17 the University of Chicago Medicine from the Cuban Society of Cardiology and appointed to the Board with Ingalls Health System to provide electrophysiology (EP), and the Heart and Vascular Center opened a of Directors of the National Board of Echocardiography interventional cardiology, and advanced heart failure services new 1,500 square foot Arrhythmia Technology • Roderick Tung, MD— Appointed to Editorial Board of Heart Rhythm Stereotaxis Suite, which employs state-of-the- • James Liao, MD — Recipient of 2016 Lifetime Scientific Achieve- • Amit Patel, MD — Named as Vice Chairman of the Oversight outside the medical center. art magnetic technology for cardiac electro- ment Award from the Chinese American Medical Society physiological mapping and ablation and is Committee for Cardiac MRI Boards and appointed the Director of Cardiac MRI/CT Program In FY 17 the Section welcomed five junior faculty the lead site in the United States evaluating • Matthew Sorrentino, MD — Appointed as Vice Chair for Clin- to enhance its heart failure, electrophysiology this new technology in patients suffering from ical Operations for the Department of Medicine • Gaurav Upadhyay, MD—Selected to the Heart Rhythm Society and research programs. Jayant Raikhelkar, MD, ventricular tachycardia. Under the direction of Emerging Leaders Program and selected to EP Council of the American assistant professor of medicine, specializes Roderick Tung, MD, the laboratory was the first College of Cardiology in heart transplantation and ventricular assist in Chicago to perform the first radiofrequency devices. Zaid Aziz, MD, assistant professor of ablation of ventricular tachycardia using this During the past year, Section of Cardiology investigators: medicine, is an interventional electrophysiologist technology. The EP lab also performed the first • Showed how deficits in a specific pathway of genes can lead to the • Conducted a six-month analysis of the pivotal MOMENTUM with academic interests in the management of two pulmonary denervation procedures to treat development of atrial fibrillation, a common irregular heartbeat, which 3 trial and found that patients implanted with the new Heart- complex arrhythmias with a particular focus in pulmonary hypertension in the United States. poses a significant health risk (Broman, et al., Science Translational Mate 3 left ventricular assist system (LVAS) had fewer adverse high density mapping of scar substrates in the Medicine, 2016) clotting and bleeding events than patients implanted with the Dr. Michael Broman heart and innovative treatment options. Karima Also contributing to the Section’s clinical control, HeartMate II LVAS (Uriel, et al., Circulation, 2017) Dr. Jayant Raikhelkar Addetia, MD, assistant professor of medicine, programs expansion was the Advanced Heart • Found that platelet ROCK2 plays an important role in the development of cardiac diastolic dysfunction (Liao, et al., Journal of Investigation Dr. Corey Tabit is a cardiac imaging expert with academic Failure (AHF)/Cardiac Transplant/Mechanical • Determined the mechanism of non-surgical bleeding in left ventricu- Insight, 2017) and in platelet function and thrombosis (Liao, et al., interests in right ventricular function and strain. Circulatory Support Program (Nir Uriel, MD– lar assist device (LVAD) patients occurs via increased angiopoietin-2 Cardiovascular Research, 2017) Adding to the cardiovascular research program Director). In FY 17, 38 adult heart transplants (Tabit, Kim, Sayer, Uriel, Liao, et al., Circulation, 2017) and tissue were the recruitments of Michael Broman, were performed with 100% survival rate to necrosis factor-alpha (Tabit, Uriel, Liao, et al., Journal of Heart & • Found novel associations with quantitative phenotypes related MD, PhD, assistant professor of medicine, date, 4 combined heart–kidney transplants Lung Transplantation, 2017) to cardiovascular disease (Cusanovich, Lang, DeCara, and Corey Tabit, MD, instructor. Dr. Broman is were performed and 52 adults received LVAD Gilad, et al., Human Molecular Genetics, 2016)

14 Department of Medicine 2017 Annual Report 15 Dr. Grossman with Dean Kenneth section of Polonsky at GDC launch computational

Dr. Robert L. Grossman biomedicine Dr. Andrey Rzhetsky and biomedical data science

was described in a Perspective in the New En- spanning nearly all branches of current nosology, gland Journal of Medicine (Grossman, et al., Octo- and 2) estimate the genetic and environmental In October 2016 the Department of Medicine announced the ber 2016) and in Blood (Jensen, et al., July, 2017) correlations between disease pairs from a set of 29 complex diseases. They found that the creation of the Section of Computational Biomedicine and Additionally, Dr. Grossman led the development genetic correlation value of each complex disease of the BloodPAC Data Commons (bloodpac.org), pair differed significantly from its environmental Biomedical Data Science (CBBDS) as the 15th subspecialty which was launched by Vice President Biden as correlation value. Furthermore, some pairs had part of the Cancer Moonshot project in October genetic and environmental correlation values section. Under the direction of Co-Chiefs, Robert L. Grossman, 2016, and is now a private-public partnership that were significantly negative in one realm of 26 companies, universities, and government and positive in the other. The majority of the PhD, and Andrey Rzhetsky, PhD, the Section provides an intel- agencies to accelerate the development and study’s narrow-sense heritability estimates were validation of liquid biopsy assays to improve the consistent with the previously published literature lectual home for faculty whose research interests encompass outcomes of patients with cancer. The value of (52 out of 65 estimates matched to previously blood profiling in assessing and monitoring cancer published estimates), and 84 of his estimates computational biomedicine, biomedical data science and bio- was recently illustrated in Clinical Pharmacology appear to be obtained for the first time. The & Therapeutics (Grossman, et al., 2017). Also relatively small estimates of common-parental and medical informatics. in 2017, supported by a grant from the Cohen common-sibling environments are notable given Veterans Bioscience (CVB) Foundation, Dr. the scale of the data. A systematic assessment analyses aimed at elucidating the causes of of infection changes in the county’s neighbors Biomedical data science and computational Computation Institute, is an expert in computa- Grossman began the development of a data of the genetic and environmental relationships influenza outbreak, Dr. Rzhetsky found that the and the county itself, in the recent past. The data biomedicine are becoming increasingly important tional analysis of complex human phenotypes. commons, called the Brain Commons, to support among diseases offers considerable advantages weather’s role in this matter is distinct from that shows that typical US epidemics start in the for making discoveries in the biological sciences, precision medicine for brain health, including as an approach to disease classification, with proposed in the literature and extends beyond southern continental coastline, and that infection for improving medical care, and for contributing In FY 17, Dr. Grossman continued to lead efforts the diagnosis and treatment of PTSD, traumatic potential for both improved understanding of the drops in humidity which precede infection waves flow from south to north, and inland. As to the emerging field of digital health, and Dr. relating to the unique information system called the brain injury and major depressive disorders. disease mechanisms and additional insight into onset. He used several, very large geo-tempo- expected, influenza propagation is affected by Grossman and Dr. Rzhetsky are leaders in these Genomic Data Commons (GDC) to host, analyze therapies that might be effective across diseases ral datasets, spanning the continental US for human movement (both long-and short-range), fields. Dr. Grossman, the Frederick H. Rawson and share genomic and clinical data from patients In FY 17, Dr. Rzhetsky led several projects with shared genetic or environmental etiology. more than nine years. These datasets include: but the contribution of short-range land move- Professor, Chief Research Informatics Officer of with cancer and connect it the cancer research focused on computational analysis of complex insurance claims for over 150 million people, ment dominates disease spread. Additionally, he the Biological Sciences Division and Director of community. The GDC was launched in June of human phenotypes. He and his team analyzed Another project led by Dr. Rzhetsky focused on human movement patterns inferred from billions of found that influenza epidemics are triggered by a the Center for Data Intensive Science, is an expert 2016 as part of President Obama’s Precision Med- the medical records for over a third of the entire causal analysis of outbreaks of seasonal influen- tweets, and whole-US weekly weather data cover- conjunction of several factors: weather condi- in data intensive computing and its applications icine Initiative, following two years of initial develop- United States population to create a subset of za. State-of-the-art research points to a seasonal ing the same time span as the medical records. tions (beyond just a drop in specific humidity), to biology, medicine and healthcare. Dr. Rzhetsky, ment with the goal to promote precision medicine 128,989 families (481,657 unique individuals). drop in humidity, which increases virus stability He also explicitly accounted for the temporal and proximity to major airports, demographics, and the Edna K. Papazian Professor of Medicine approaches to the diagnoses and treatment of can- The team then used this subset to 1) estimate the and thus the duration of its infectious, air-borne spatial auto-correlations of an infectious wave, degree of urbanity. Results from these studies and Human Genetics and Senior Fellow of the cer. The impact of the GDC on precision medicine heritability and familial patterns of 149 diseases, circulation. Using three orthogonal statistical predicting infection in each county as a function were recently published in Nature Genetics.

16 Department of Medicine 2017 Annual Report 17 Professors: Clinical Associates: Vesna Petronic-Rosic, MD Juliana Basko-Plluska, MD (Chief) Arlene Ruiz De Luzuriaga, MD, Christopher R. Shea, MD Keyoumars Soltani, MD Associate Member: Amy Derick, MD Associate Professors: Sarah L. Stein, MD Section Administrator: Yu-Ying He, PhD Nishq Mody

Assistant Professors: Diana Bolotin, MD, PhD Adena Rosenblatt, MD, PhD Dr. Vesna Petronic-Rosic Part-Time Faculty: section of Vivek Iyengar, MD dermatology 2017 Dermatology faculty Derick is the owner and Chief Medical Officer at molecular insights for developing effective GG- of medicine. Dr. Rosenblatt’s goal is to build a Derick Dermatology which operates 4 practices NER modulators for cancer prevention and ther- comprehensive pediatric dermatology clinical in the far northwestern suburbs of Chicago and apy. In FY 17, Dr. He was the recipient of a Janet practice focused on the diagnosis and manage- is recognized as a Chicago magazine (Janu- D. Rowley Discovery Award to further her work in In May 2017, Vesna Petronic-Rosic, MD, was appointed Chief ment of childhood skin diseases. Dr. Rosenblatt ary 2017) Top Dermatology Cancer Doctor. defining the role of RNA methylation in melanoma. of the Section of Dermatology after leading the Section in an has a special interest in vascular skin lesions and is a member of the Vascular Anomalies The Section’s investigative programs are focused The Dermatology Residency Program (Sarah interim capacity for the past year. Dr. Petronic-Rosic joined the Group at the University of Chicago. As a phy- on the fundamental question of how cells respond Stein, MD–Director), continues to recruit and sician-scientist, Dr. Rosenblatt has a particular to radiation and chemicals from internal or train outstanding young dermatologists and faculty of the Department of Medicine in 2003 where, in addition interest in quality improvement and ensuring external sources to cause cancer. Dr. Yu-Ying works to foster the core values of collegiality, patient access to healthcare. She is exploring He’s laboratory continues to investigate the scholarship, professionalism, and accountabili- to her new role as Chief, she currently serves as Professor of innovative ways to use information technology mechanism of global genome nucleotide excision ty. The Dermatopathology Fellowship Program, Dr. Adena Rosenblatt and teledermatology to enhance patient care. repair (GG-NER) regulation by autophagy, and its led by Dr. Petronic-Rosic, also remains strong, Dermatology and Pathology and Director of the Dermatopathol- The Section also welcomed Amy Derick, MD, impact on UVB-induced skin tumorigenesis and providing an excellent training experience to an as its inaugural Associate Member in 2017. Dr. tumor progression with the hope to provide new elite group of dermatologists and pathologists. ogy Fellowship Training Program. While working to strengthen As one of the top programs in the nation focused on understanding, diagnosing, and treating the the clinical, research and educational programs of the Section skin and its diseases, the Section of Dermatology is committed to providing outstanding patient Impactful Accomplishments, Highlights, and Discoveries: The Section of Dermatology’s investigative programs of Dermatology, Dr. Petronic-Rosic’s vision also includes the care, creating innovative research, and training have continued to make key contributions to research the future leaders in the field. In the clinical enter- in skin conditions, carcinogenesis, and melanocyte creation of a Skin Cancer Center of Excellence, a premier center prise, the Section continues to be productive in • Vesna Petronic-Rosic, MD — • Arlene Ruiz De Luzuriaga, MD — differentiation. Significant highlights include: outpatient visits and procedures, and in providing Recipient of the 2017 Exceptional Women Recipient of Castle Connolly’s 2017 for diagnosis, treatment and comprehensive care of patients with the highest quality interpretation of dermatopa- in Medicine Award from Castle Connol- Exceptional Women in Medicine Award • Provided new insights into the preven- thology cases. In recognition of their outstanding ly and named as Treasurer, International and named as Editor of Research tion of arsenic induced skin cancer melanoma and non-melanoma skin cancers, as well as patients patient care, three faculty were recognized by Academy of Cosmetic Dermatology Techniques Made Simple for the Jour- (Shah, He, et al, Molecules, 2017) Chicago magazine (January 2017) as Top Der- nal of Investigative Dermatology; whose skin is affected by treatments for other cancers or who matology Cancer Doctors: Drs. Petronic - Rosic, • Christopher R. Shea, MD — • Defined new molecular insights into the role are at high risk of developing skin cancer due to other diseases Christopher Shea and Diana Bolotin. Arlene Served as Editor in Chief of the Journal of • Juliana Basko-Plluska, MD — of autophagy in tumor cell survival which Ruiz De Luzuriaga, MD, MPH, was recognized Cutaneous Pathology and was the recipient Appointed to the editorial board of may facilitate the development of improved or treatments. by Castle Connelly as a Top Doctor in 2016. of the Founders Award from the American Clinical and Cosmetic Dermatology. therapeutic strategies for targeting auto- Society of Dermatopathology, in recognition phagy for cancer therapy (Yang, He et al, In FY 17, Adena Rosenblatt, MD, PhD, joined the of his outstanding original and significant Journal of Biological Chemistry, 2017) Section of Dermatology as assistant professor contributions to the field of Dermatopathology

18 Department of Medicine 2017 Annual Report 19 Impactful Accomplishments, Highlights, and Discoveries:

• Nanduri Prabhakar, PhD – Elected as a Fellow of the American Physiological Society

• Robert Mulliken, MD – Recipient of the 2017 Department of Dr. Linda Druelinger Medicine’s Overall Clinical Activity and Drs. Peng and Fang at Dr. Daniel Robinson Evaluation and Management Awards section of 2017 Research Day Dr. Alfredo Garcia • Aasim Padela, MD – Accepted into In FY 17 two new faculty were welcomed to the ygen Sensing (Nanduri Prabhakar, PhD–Director) the Mid-Career Leadership Program of Section. Daniel Robinson, MD, assistant professor work continued on the effects of systemic, cellular the Society of Behavioral Medicine of medicine, focuses his work on medical simula- and molecular responses to chronic intermittent emergency tion and medical education. He utilizes simulation hypoxia and on therapeutic targeting of carotid • Willard Sharp, MD, PhD – as a novel tool for introducing new procedures, body chemoreflex for sleep disordered breathing. Best Abstract Award (Basic Re- skills, and teamwork to medical students, resident search), 2017 Department of Medicine physicians, and practicing physicians as well as As one of the oldest emergency medicine training Janet D. Rowley Research Day nurses and EMTs. Alfredo Garcia, PhD, assis- programs in the country, the Emergency Med- medicine tant professor of medicine joined the Section’s icine Residency Program (Christine Babcock, research programs. Dr. Garcia has a broad MD–Director) continues to attract trainees from During the past year, Section of research interests in the influence of local neuronal outstanding medical schools, many of whom are Emergency Medicine investigators: environments on neurodevelopment and the co- successfully securing sought after fellowship ordination of information among neural networks. positions after completing residency training. • Demonstrated that imbalanced expres- Under the direction of Linda Druelinger, MD the Section of Emergency Medicine continues to His work has implications for the understanding Dr. Babcock has gained regional recognition for sion of gaseous transmitters carbon of the neural basis for autonomic function and her work with the Illinois College of Emergency monoxide and H2S leads to obstructive maintain its stature as a nationally prominent emergency medicine program. Over the past year, cognitive dysfunction in conditions ranging from Physicians (ICEP) and was elected to the Board and central sleep apnea (Peng, Prabha- opioid overdose to epilepsy and sleep apnea. of Directors as well as a member of the Executive kar, et al., Proceedings of the National the Section’s efforts have been focused on preparing for the opening of the new emergency Board for the College. Dr. Babcock will represent Academy of Sciences, USA, 2017). In the research realm, the Section was award- the state of Illinois as Councilor at the national department (ED) planned for January 8, 2018. With leadership from Thomas Spiegel, MD, the ED ed nearly $5M in extramural research funding. American College of Emergency Physicians • Showed that epigenetic regulation of New grants in FY 17 include a NIH funded R01 (ACEP) Council meeting. Naveet Cheema, MD, redox state mediates persistent cardio- Medical Director, many operational improvements were achieved relating to throughput including awarded to Willard Sharp, MD, PhD focused on and David Harter, MD, were honored by the respiratory abnormalities in a rodent pharmacological induced torpor/hypothermia as Emergency Medicine residents with the Out- model of sleep apnea. (Nanduri, et the use of data driven metrics to evaluate the decision time to discharge after completion of lab- a novel therapy for improving post cardiac arrest standing Faculty Mentorship Award and Out- al., Journal of Physiology, 2017) resuscitation outcomes. Within the Center for Ox- standing Clinical Teacher Awards, respectively. oratory and imaging studies. In addition, plans were developed for an extended coverage model • Found that religious beliefs influence deci- sions to pursue mammography across the that places a doctor ‘up front’ to facilitate the door to doctor time and work up of patients pre- Professors: Assistant Professors: Clinical Associates: ethnic/racial diversity of Muslim women Linda Druelinger, MD (Chief) Claire Abramoff, MD+ Kimberly Stanford, MD+ Diane Chaney, MD ( Padela et al., Psychooncology, 2016) senting to the ED and to meet the clinical care needs based on an increase in patient volume of Ira Blumen, MD James Ahn, MD Katie Tataris, MD David Harter, MD David Howes, MD Christine Babcock, MD Julianne Kjolhede, MD+ • Designed a clinical intervention, 65,000 annual visits in FY 18. Also in FY 17, Teresita Hogan, MD, Director of Geriatric Emergen- Jayasri Nanduri, PhD* Krystal Baciak, MD+ Part time Faculty: I-PREP (Improving Pain Relief in Elder Nanduri Prabhakar, PhD Keegan Checkett, MD Eric Beck, DO Medical Education Fellow: Patients) that significantly improved cy Medicine, led efforts that successfully resulted in the selection of University of Chicago Medi- James Walter, MD Navneet Cheema, MD Andrew Bokarius, MD Paul Kukulski, MD+ pain management for older adults in Alfredo Garcia, PhD Thomas Fisher, MD Eric Shappell, MD the ED (Hogan, et al., Journal of the cine’s ED as a member of the Geriatric Emergency Department Collaborative (GEDC), a project Associate Professors: Nadim Hafez, MD+ Cai Glushak, MD American Geriatrics Society, 2016) David Beiser, MS, MD Gregg Helland, MD Kamaldeep Heyer, MD Section Administrator: funded by the John Hartford and Gary and Mary West Foundations, with a goal of establishing Keme Carter, MD P. Quincy Moore, MD+ Murray Keene, MD Bradford Lane (interim) Teresita Hogan, MD Alejandro Palma, MD+ Marshall Segal, MD GED guideline initiatives to improve ED elder care. Robert Mulliken, MD John Purakal, MD+ *Research Appointee Track Faculty Aasim Padela, MD Daniel Robinson, MD + new FY 18 faculty Ying-Jie Peng, PhD* Willard Sharp, MD, PhD Thomas Spiegel, MD

20 Department of Medicine 2017 Annual Report 21 Professors: Assistant Professors: George Bakris, MD Alexandra Dumitrescu, MD, PhD Graeme Bell, PhD Siri Atima Greeley, MD, PhD Ali Cinar, PhD* Erin Hanlon, PhD* David Ehrmann, MD Rochelle Naylor, MD Murray Favus, MD Katie O’Sullivan, MD+ section of Louis Philipson, MD, PhD Decheng Ren, PhD* Kenneth Polonsky, MD Susan Sam, MD Samuel Refetoff, MD** Celeste Thomas, MD Dr. Ronald Cohen Christopher Rhodes, PhD** Christine Yu, MD Eve Van Cauter, PhD** Meltem Zeytinoglu, MD endocrinology, Tamara Vokes, MD Clinical Associates: Research Day 2017 Associate Professors: David Sarne, MD Ronald Cohen, MD (Chief) Farah Hasan, MD dent Toni Preckwinkle, Medtronic Chief Medical programs. With two NIH T32 grants to support Matthew Brady, PhD diabetes and Officer Francine R Kaufman, MD, and Elbert training in pediatric endocrinology research and Dianne Deplewski, MD Section Administrator: Huang, MD, and was moderated by Mary Ann integrated clinical and basic endocrinology, there Manami Hara, PhD* Ann M. Leu Ahern, Political Reporter for NBC5 News. is no other such program in the United States. In Silvana Pannain, MD FY 17, the dual program successfully graduated Ann Zmuda, DPM *Research Appointee Track Faculty The Thyroid Study Unit (Samuel Refetoff, MD– its 4th fellow, Katie O’Sullivan, MD, who joined **Emeritus metabolism Director) continues to work on the identification the faculty in August 2017. The Endocrinology +New FY 18 faculty and treatment of congenital thyroid diseases, T32 Training Program (Graeme Bell, PhD and in particular those that cannot be managed by Samuel Refetoff, MD - PIs) completed its 42nd sions on diabetes and emotional health, diabetes simple hormone replacement. In FY 17, research- year of training endocrinology researchers, and the complications and diabetes and exercise. ers identified alterations in the gene for DUOX2 program competitively renewed for five additional Under the direction of Ronald Cohen, MD, the Section of as a new cause of resistance to thyrotropin. years of funding from the National Institutes of The Section’s internationally recognized investiga- Health. The Committee on Molecular Metabo- Endocrinology, Diabetes and Metabolism continues to maintain tors have made important scientific contributions One of the unique aspects of the Section is the fully lism and Nutrition (Matthew Brady, PhD–Chair) that have impacted our understanding of diabe- integrated nature of the adult and pediatric training successfully graduated five doctoral students. its impressive stature as one of the top adult and pediatric tes, thyroid disease, sleep and polycystic ovary disease. In FY 17, the Section was the recipient endocrine centers as well as enjoy great success for its of over $5.4M in total grant funding. New grants Highlights, Discoveries, and Accomplishments: include an NIH R01 for Louis Philipson, MD, PhD, outstanding research and educational programs. The ability to to evaluate the consequences of a diagnosis of • George Bakris, MD – Named as Chair of the Steering Committee for During the past year, Section of Endocrinology, monogenic diabetes and to develop and validate CALM-FIM Outcome Trial in United States to evaluate a Mobius device Diabetes and Metabolism investigators: directly connect adult and pediatric researchers and clinicians new cost-effective methods to improve diagnosis for resistant hypertension • Performed a whole-genome sequencing study on the genetic architecture and treatment. Siri Greeley, MD, PhD, was the of diabetes that provided important clues about lower frequency variants has enabled the Section to be a leader in understanding the recipient on an American Diabetes Association • Graeme Bell, PhD – Awarded the Department of Medicine’s 2017 in the role of type 2 diabetes (Fuchsberger, Bell, et al., Nature, 2016) grant to investigate the impact of diabetes in Arthur H. Rubenstein Mentorship in Academic Medicine Award genetics of diabetes and thyroid disorders, and to translate these infancy. Alexandra Dumitrescu, MD, PhD, was • Provided new insights into the role of high-sensitivity troponin and car- awarded an NIH R01 to study rare genetic • Matthew Brady, PhD – Awarded the 2017 Francis Straus Mentor- diovascular outcomes in patients with diabetes (Cavender, Bakris, et al., advances to the care of patients. syndromes caused by SBP2 mutations. Rochelle ship Award from the Biological Sciences Division and appointed as a Circulation, 2017) Naylor, MD, also received notification of an NIH standing member of the National Institutes of Health Cellular Aspects K08 award to develop a personalized genetic of Diabetes and Obesity grant review panel • New insights into the interaction between circadian rhythms and bariatric In FY 17, the Section’s clinical and outreach to enhance diabetes treatment of individuals in medicine approach for patients with maturity-onset surgery to improve metabolic health (Brady, et al., American Journal of programs were highlighted by several new prisons, jails, and juvenile detention centers. She diabetes of the young in a multi-ethnic population. • Ronald Cohen, MD – Recipient of the Department of Medicine’s Physiology, 2016) initiatives. The Chicago Weight Program (Silvana also co-chaired the Hypoglycemia Oversight 2017 Patient Satisfaction Award Pannain, MD–Director), a multidisciplinary Committee to institute best practices regarding The Kovler Diabetes Center celebrated its • Demonstrated that patients with KCNJ11-related diabetes frequently have program involving endocrinologists, nutritionists, insulin therapy in hospitalized patients at the Uni- 10th anniversary as the premier destination • Samuel Refetoff, MD – Served as the keynote speaker at Sociedad neuropsychological impairments compared with sibling controls (Greeley, and psychologists that focuses on patients with versity of Chicago Medicine. The Kovler Diabetes for diabetes care and for world-class scientific Española de Endocrinología y Nutrición, Malaga, Spain Naylor, Philipson, et al., Diabetic Metabolism, 2016) obesity, was enhanced with the addition of a Center (Louis Philipson, MD, PhD–Director) research. As part of the celebration, the Cen- clinic focusing on weight management of women hosted four Living Well with Diabetes seminars ter hosted over 100 guests to “Salon Kovler: • Eve Van Cauter, PhD – Served as the Plenary Speaker at the Société • Identified a novel form of resistance to the hormone thy- with PCOS in collaboration with Susan Sam, for adults with diabetes in the local community. The Politics and Economics of Diabetes” on Française du Sommeileil, Strasbourg, France rotropin (Refetoff, et al., Thyroid, 2017) MD. Celeste Thomas, MD, partnered with the In total, more than 300 individuals attended the November 14th, 2016. This event featured National Commission on Correctional Healthcare free community programs that included discus- conversations with Cook County Board Presi-

22 Department of Medicine 2017 Annual Report 23 basic/translational research agenda combines Unique Highlights, assets of the Biological Sciences Division, Accomplishments, and Marine Biological Laboratory, and Argonne Discoveries: National Laboratory to investigate the role of the intestinal microbiome that impacts health and disease, gut immune regulation and oral • Bana Jabri, MD, PhD — Recipient 2017 of the tolerance, host genetic factors, celiac disease, University of Chicago’s Llewellyn John and Har- and pathobiology of GI cancers. In FY 17, the riet Manchester Quantrell Award for Excellence Section was awarded multiple new federal and in Undergraduate Education section of non-federal grants including a new NIH R01 Dr. David T. Rubin awarded to Dr. Chang to explore paneth cell • Carol Semrad, MD — Recipient of the American peptide YY in the pathogenesis of ileal Crohn’s Society for Parenteral and Enteral Nutrition’s disease. Dr. Leone was awarded an NIH K08 to Excellence in Nutrition Support Education Award study diurnal oscillations in gut microbes and gastroenterology, host immunity in health and obesity and Joel • Sonia Kupfer, MD — Recipient of the Biologi- Pekow, MD, secured an NIH R03 to investigate cal Sciences Division’s Distinguished Leader in new models to dissect molecular pathways Diversity and Inclusion Award in IBD-neoplasia using human colonoids. Dr. Rubin received a multi-year grant from Takeda • Marc Bissonnette, MD— Recipient of the hepatology and Pharmaceuticals to study quality of life in IBD Pritzker School of Medicine’s 2017 John D patients using passive biosensors. Through Arnold Mentor Award ongoing support from industry partnerships and support from Gastro-Intestinal Research During the past year, Section of Foundation, the Section expanded its trans- nutrition lational core (Joel Pekow, MD–Director) Gastroenterology, Hepatology and a multidisciplinary liver tumor clinic. Dr. Paul has a with biospecimens across multiple subspe- Nutrition investigators: particular interest in hepatitis B, autoimmune and cialties from more than 7,000 patients. Under the direction of David T. Rubin, MD the Section of Gastro- cholestatic liver diseases, and liver transplantation. Dr. Chapman, assistant professor of medicine, In the educational realm, Sonia Kupfer, MD • Discovered that the onset of Celiac disease enterology, Hepatology and Nutrition continued its growth across specializes in interventional gastroenterology Dr. Michael Carlton, Dr. Christopher Chapman, was named the Associate Section Chief for could be triggered by prior Reovirus infection including novel endoscopic procedures for weight Dr.Vanessa Leone, Dr. Anjana Pillai, Dr. Jeannette Messer, and educational programs. The Section’s training (Jabri et al., Science, 2017) the clinical, research and educational programs. In FY 17 the loss and bariatric surgery and serves as director of Dr. Sonali Paul program (Gautham Reddy, MD–Director) the new Metabolic Endoscopy Program and co-di- had a very successful fellowship match and • Provided a compelling argument to rethink and Section expanded its clinical programs to University of Chicago rector of the GI Obesity Program. The Section’s The Section’s research portfolio continues to be performed a thorough review and update correct current practices of indiscriminate and Microbiome Research Program (Eugene Chang, strong, with nearly $10 million in annual total cost of the GI fellowship curriculum. The Sec- empirical use of antibiotics during the peripartum Medicine’s (UCM) offsite clinics in Chicago and at satellite clinics MD–Director) was expanded with the recruit- funding across multiple subspecialties. Under tion also hosted multiple CME programs, period (Myoshi, Chang, et al., Cell Reports, 2017) ments of two pathway instructors, Drs. Leone and the direction of Associate Section Chief Eugene and two annual and nationally recognized in Indiana. Other major sectional accomplishments include suc- Messer. Dr. Leone’s work examines the influence of B. Chang, MD, and Bana Jabri, MD, PhD, the interventional endoscopy conferences. • Described the findings from two phase I clinical the gut microbiome on complex disease develop- trials to treat celiac disease using the therapeu- cessful recruitment of three hepatologists, including a Director of ment. Dr. Messer’s work focuses on the field of tic vaccine, Nexvax2, that renders gluten-specif- host-microbe interactions in IBD and colorectal Professors: Secondary Appointments ic CD4-positive T cells unresponsive to further the Center for Liver Diseases, the growth of the research faculty, cancer. Both have been successful in obtaining David Rubin, MD (Chief) Anjana Pillai, MD Atsushi Sakuraba, MD Alexander Chervonsky, PhD antigenic stimulation (Goel, Jabri, Anderson, et NIH K career development awards for 5 years. Eugene B. Chang, MD Kapuluru Gautham Reddy, MD Neil Sengupta, MD Erika Claud, PhD al., Lancet Gastroenterology, 2017) and a thorough review and update of the educational programs Michael Charlton, MD Uzma Siddiqui, MD John Hart, MD The Inflammatory Bowel Disease Center (Russell Russell Cohen, MD Instructors: Cathryn Nagler, PhD • Found that miR-193a-3p is downregulated in ul- to ensure that the Section continues to lead the country in the Cohen, MD–Director) continued to lead IBD care Ira Hanan, MD Assistant Professors: Vanessa Leone, PhD cerative colitis neoplasia, and its loss promotes in the region and as one of the country’s preemi- Bana Jabri, MD, PhD Christopher Chapman, MD Jeannette Messer, DVM, PhD Clinical Associate: carcinogenesis through upregulation of IL17RD. training of new academic gastroenterologists. nent programs. Andrew Aronsohn, MD is leading Karen Kim, MD Sushila Dalal, MD Bertram Rogers, MD This finding suggested potential new thereputic a telehealth initiative as part of a grant from the Carol Semrad, MD Murat Eren, PhD Clinical Associates: targets for the treatment of colon cancer. (Pe- Centers for Disease Control and Prevention to Irving Waxman, MD Yong Huang, PhD* Bertram Rogers, MD Section Administrator: kow, Rubin, Bissonnette, et al., Clinical Cancer In FY 17, the Section welcomed six new faculty: co-director of the UCM’s restructured Transplant battle hepatitis C in Chicago. In FY 17, the Section Helen Te, MD Robert Kavitt, MD Mark Mitchell Research, 2017) Drs. Michael Charlton, Christopher Chapman, Institute. Joining Dr. Charlton in the Center for expanded this initiative to include telehealth confer- Charles Winans, MD** Sonia Kupfer, MD Part Time Faculty Sonali Paul, Anjana Pillai, Vanessa Leone and Liver Diseases are Dr. Pillai, associate professor ences for the treatment of IBD. The Liver Transplant Edwin McDonald III, MD (Co-appointment with ANL): + New Faculty FY 18 • Used novel analytical strategies to provide Jeannette Messer. Dr. Charlton, professor of of medicine and Dr. Paul, assistant professor of Program (Helen Te, MD–Director) continued to Associate Professors: Dejan Micic, MD+ Dionysios Antonopoulos, PhD *Research Appointee Track Faculty genomic insights into bacterial popula- medicine, is an international leader in hepatology medicine. Dr. Pillai’s research is focused on viral grow with the opening of two off-site clinics in Indi- Andrew Aronsohn, MD Sonali Paul, MD Folker Meyer, PhD **Emeritus tions that may be critical to the efficacy and liver transplantation and director of the Center hepatitis and hepatocellular carcinoma. Within the ana. The metrics of transplant wait-list mortality and Marc Bissonnette, MD Joel Pekow, MD of fecal microbiota transplantation (Lee, for Liver Diseases and the Department’s first Department, Dr. Pillai is developing and directing post-transplant survival are the best in the region. Yanchun Li, PhD Vijaya Rao, MD+ Rubin, Eren, et al., Microbiome, 2017)

24 Department of Medicine 2017 Annual Report 25 tant professor of medicine, is developing a women’s renewal of the NIH funded Chicago Cen- Professors: Assistant Professors: health curriculum for internal medicine residents. ter for Diabetes Translation Research (P30) Deborah Burnet, MD (Chief) Nabil Abou Baker, MD+ and Elbert Huang, MD received an NIH R56 Diane Altkorn, MD Jason Alexander, MD Under direction of Lisa Vinci, MD the Primary Care multiple PI award to study diabetes care and Halina Brukner, MD Irsk Anderson, MD Group (PCG) cared for approximately 25,000 outcomes in a diverse elderly population. Marshall Chin, MD Mim Ari, MD+ patients through 56,000 patient encounters during Adam Cifu, MD Arshiya Baig, MD, FY 17. GIM is leading development of the new GIM faculty are implementing novel community- Elbert Huang, MD Kamala Cotts, MD population health and value-based care initiatives based research and education to address health Mindy Schwartz, MD Neda Laiteerapong, MD at UCM. To target services where they are needed disparities in Chicago and beyond. Drs. Marshall Mark Siegler, MD Wei Wei Lee, MD most, George Weyer, MD designed and directs Chin, Arshiya Baig, Scott Cook, Elbert Huang, Scott Stern, MD Valerie Press, MD UCM’s new Outpatient Complex Care Coordina- Neda Laiteerapong, Monica Peek and Monica James Woodruff, MD Jennifer Rusiecki, MD Dr. Deborah Burnet tion Program for vulnerable patients, coordinating Vela lead an initiative to study and improve shared Monica Vela, MD Milda Saunders, MD section of high-touch care for medically complex patients and decision making between clinicians and LGBTQ Lisa Vinci, MD Sachin Shah, MD building powerful connections across our expand- patients of color within healthcare systems. Drs. Todd Stern, MD ing regional health system. To more effectively track Volerman and Burnet are working with local schools Associate Professors: Anna Volerman Beaser, MD our primary care patient population, Chief Medical on Chicago’s South Side to improve health for Vineet Arora, MD George Weyer, MD Informatics Officer David Liebovitz, MD, Sachin children with asthma and to decrease obesity Dionne Blackman, MD general internal Shah, MD and other GIM faculty are leading the through healthy nutrition and exercise in partnership Andrew Davis, MD Instructor: design and implementation of a new electronic with Pilot Light, a collaborative of Chicago’s elite Rajlakshmi Krishnamurthy, MD Elizabeth Tung, MD health record tool, ‘Healthy Planet,’ to help clinicians chefs. Dr. Miller conducts an on-going series of Patricia Kurtz, MD oversee and care for their panels of patients. ‘Community Grand Rounds,’ connecting health David Liebovitz, MD Clinical Associates: The MacLean Center for Clinical Medical Ethics speakers with community groups to address a Doriane Miller, MD Joseph Asbury, MD medicine (Mark Siegler, MD - Director) trained 35 ethics variety of health and social topics. Dr. Baig connects Julie Oyler, MD Marius Commodore, MD fellows over the past year. Now in its third year, the with churches in Pilsen-Little Village to conduct Monica Peek, MD Ashley Martin, MD FY 17 faculty awards include: Dr. Burnet received LUCENT Primary Care Program (Leading Urban diabetes empowerment classes for Spanish- Amber Pincavage, MD Sandra Naaman, MD the national Chief’s Recognition Award from Primary Care Education and Transformation) speaking patients and family members. Drs. Miller Rita Rossi-Foulkes, MD Katarina Veskovic, MD the Association of Chiefs & Leaders of General (Deborah Burnet, MD and Anna Volerman, MD - Di- and Burnet lead the UC Institute for Translational Under the leadership of Deborah Burnet, MD, Internal Medicine. Vineet Arora, MD was elected rectors) trains and supports primary care residents, Medicine Community Cluster, partnering with Section Administrator: to the American Society for Clinical Investigation fellows and faculty as they develop leadership the Chicago Department of Public Health, Cindy Kitching the Section of General Internal Medicine (GIM) and named a Master of the Society of Hospital skills and implement practice-based innovation organizations and colleagues city-wide to promote +new FY 18 faculty Medicine. Mark Siegler, MD received the Harvey projects on campus and in community sites. research and policy to improve Chicago’s health. comprises highly talented faculty dedicated to M. Meyerhoff Leadership in Bioethics Award from connections from research to practice. Drs. the Johns Hopkins Berman Institute of Bioethics. In FY 17, GIM faculty were successfully award- GIM faculty are national leaders in promot- Andy Davis and Adam Cifu serve as editors for providing exceptional clinical care, teaching Institutionally, Rita Rossi Foulkes, MD was named ed approximately $4.3 million in research ing and disseminating the most up to date the influential JAMA Clinical Guidelines Syn- as Inaugural University of Chicago Medicine funding. Marshall Chin, MD led the successful evidence-based practices, building powerful opsis series, publishing 14 pieces in FY 17. and leading our educational programs, and Program Director of the Year. Monica Vela, MD received the Biological Sciences Division Distin- building powerful connections to conduct guished Leader in Diversity and Inclusion Award. Highlights, Discoveries, and Accomplishments: Anna Volerman Beaser, MD received the BSD innovative, real-world research addressing Distinguished Leader in Community Service • Jason Alexander, MD – Recipient of the 2017 Department and Advocacy Award, and Kamala Cotts, MD of Medicine Clinical Productivity Award. During the past year, Section of health disparities. The Section is home to received the BSD Distinguished Junior Clinician General Internal Medicine investigators: Award. Within the Department of Medicine, • Elbert Huang, MD – Appointed as a NIDDK-B Standing Study Section several outstanding multidisciplinary academic Monica Peek, MD received the Leif B. Sorensen, member, reviewing career development award applications and training grants • Evaluated relevant statutes related to alternate decision makers when patients MD Faculty Research Award, and Doriane Miller, lost decisional capacity (DeMartino, Siegler, et al., New England Journal of centers and programs including the MacLean MD was named as the Diversity Award winner. • Neda Laiteerapong, MD – Recipient of the Midwest Society of Gen- Medicine, 2017) eral Internal Medicine Award for Excellence in Clinical Investigation Center for Clinical Medical Ethics, the Chicago GIM welcomed three new faculty to the Section in • Showed an association between inpatient sleep loss and hyperglycemia FY 17. Rajlakshmi (Raj) Krishnamurthy, MD, associ- • Wei Wei Lee, MD – Recipient of the Midwest Society of General in hospitalized patients with and without diabetes (Arora, et al., Diabetes Center for Diabetes Translation Research, and ate professor of medicine, serves as Chief Clinical Internal Medicine Clinician Educator Award and the Bucksbaum Care, 2017) Transformation Officer for UCM overseeing the Institute for Clinical Excellence Junior Faculty Scholar Award the Center for Translational and Policy Research further development of the ambulatory health system • Determined that Asian Americans were the least likely racial and ethnic group efforts and clinical programs related to value-based • Doriane Miller, MD – Recipient of the Midwest SGIM to receive recommended diabetes screening, despite their high risk of diabetes for Chronic Diseases. Dr. Jason Alexander care and population health. Jason Alexander, MD, Advocacy and Community Service Award (Tung, et al., Journal of General Internal Medicine, 2016) Dr. Rajlakshmi Krishnamurthy assistant professor of medicine, has academic inter- Dr. Jennifer Rusiecki ests focused on curriculum development and teach- • Monica Peek, MD – Appointed to the Editorial • Showed an association between insurance status and mortality in indi- ing clinical reasoning. Jennifer Rusiecki, MD, assis- Board for Health Services Research viduals with albuminuria (Saunders, et al., BMC Nephrology, 2016)

26 Department of Medicine 2017 Annual Report 27

The University of Chicago & Argonne National Laboratory Joint Retreat “Single Cell and Nano Technology”

OPENING REMARKS

T. Conrad Gilliam, Ph.D. Thursday Dean for Research and Graduate Education, U of C

Everett Vokes, M.D. October 6, 2016 Chair, Department of Medicine, U of C

Supratik Guha, Ph.D. 10:00 AM — 2:00 PM Director, Center for Nanoscale Materials & the Nanoscience Technology Division, ANL Knapp Center for

PRESENTATIONS Biomedical Discovery

Tijana Rajh, Ph.D. (KCBD) Deputy Director, Nanoscience Technology Division, Auditorium 1103 ANL Dr. Yoav Gilad Savas Tay, Ph.D. The Institute for Molecular Engineering, U of C

Gary Wiederrecht, Ph.D. Nanophotonics & Biofunctional Structures Group, ANL

Mark Ratain, M.D. Director, Center for Personalized Therapeutics, U of C Join us for presentations and Elena Rozhkova, Ph.D. discussions on focused single Nanophotonics & Biofunctional Structures Group, ANL cell approaches and Nano Anindita Basu, Ph.D. technologies as they relate to Broad Institute of MIT and Harvard genomic, genetic and

Leo Ocola, Ph.D. clinical research Nanofabrication and Devices Group, ANL Lunch will be served section of CLOSING REMARKS Persons with disabilities, who need

Yoav Gilad, Ph.D. assistance, please call Sue Levison at 773.702.2464 Chief, Section of Genetic Medicine, U of C

rials. She will draw from these diverse disciplines genetic medicine to aid in the diagnosis and treatment of human disease through new devices technologies. As a joint appointee at Argonne National Lab, she works at the interface of science by bringing bio/nano The Section has developed a new core facility that materials, device capabilities and characterization serves the Biological Sciences Division (BSD) fac- techniques from Argonne National Lab to answer ry noise in single-cell gene expression data, Under the leadership of Yoav Gilad, PhD, the Section of Genetic ulty by training personnel to use the latest episomal pressing scientific questions in medicine, ge- identify genomic loci in which genetic variation Dr. Chen at 2017 Research Day techniques to reprogram, expand and characterize nomics, and biology to the Department. Dr. Chen is associated with inter-individual differences Medicine made significant progress in its quest to become human and mice induced pluripotent stem cells received her PhD in computation biology & bioin- in regulatory noise (robustness QTLs), and from skin or blood tissues of healthy subjects and formatics from Yale University in 2014 and served develop an understanding of the mechanisms a leader in translational genetic research at the University of diseased patients. The core also developed the as assistant professor in the Department of Bio- that underlie gene regulatory robustness. Several Professors: Section Administrator: capability to differentiate the iPS cells into specific statistics and Genetics at UNC-Chapel Hill before other high impact projects were ongoing in FY Yoav Gilad, PhD (Chief) Ann Leu Chicago in FY 17. This included the launch of new technological somatic cells, such as neutrons, cardiomyocytes, joining the Section. Dr. Chen’s interests include 17. Barbara Stranger, PhD, continued her work Dan Nicolae, PhD and hepatocytes. The Section also partnered the utilization of statistical methods to address on the genetics of gene expression in human *Research Appointee Track Faculty developments, such as single cell genomics, and a training core with the University’s Functional Genomic Facility the challenges of high throughput technologies, left ventricular myocardium. The GTEx proj- Assistant Professors: +New FY 18 faculty to develop and offer single cell genomic and particularly for data emerging from biological and ect, with one of the methodology development Anindita Basu, PhD for stem cells, establishing stronger connections with basic and gene expression data collection through two biomedical studies, such as epigenetic and cancer groups led by Dan Nicolae, PhD, continued to Mengjie Chen, PhD platforms, a Drop-SEQ and the Fluidigm C1. genomics related research. Dr. Im received her MS generate new data for characterizing genetic Hae Kyung Im, PhD clinical researchers on and off campus, and the expansion of in financial mathematics and PhD in statistics from variants implicated in transcriptome regulation, Yang Li, PhD+ In FY 17, the Section organized joint scientif- the University of Chicago. Her research centers on disease susceptibility and pharmacogenomics. Barbara Stranger, PhD the computational and statistical genetics programs with the ic retreats between UChicago and Argonne developing statistical methods to sift through the National Laboratory (ANL) investigators, which vast amounts of genomic and other high dimen- recruitment of three new faculty. were followed by an RFA for collaborative initia- sional data to understand the biological mecha- During the past year, Section of Genetic Medicine investigators: tives between the institutions. Four proposals nisms that drive complex diseases with the ultimate for collaborative work were funded this year, goal of making discoveries that can be translated • First to assess the role of genome-wide host • Identified a group of genes associated with including two from the Department of Medicine. into improving health. Dr. Im’s current work is genetic variation in shaping the human micro- hypoxia response in aggressive neuroblas- supported by an NIH R01 where she is developing biome at two upper airway sites and provided toma potentially representing a novel target Joining the Section of Genetic Medicine in FY 17 a novel computational method that links mecha- evidence of host genetic influences on upper for biomarker and therapeutic development Dr. Hae Kyung Im were three assistant professors of medicine, Drs. nistically the genetic variability to disease risk and airway microbial composition in humans and (Applebaum, Godley, Stranger, Prabhakar, et Dr. Anindita Basu Anindita Basu, Mengjie Chen and Hae Kyung Im. applies it to a range of mental disorder studies to implicate mucosal immunity genes in this al., Oncotarget, 2016). Dr. Mengjie Chen Dr. Basu received her PhD in physics from the Uni- provide more biological insights and enable dis- relationship (Igartua, Gilad, Nicolae, et al., versity of Pennsylvania in 2016 and completed her covery of potential targets for drug development. Microbiome, 2017) • Developed SynthEx, a novel tool for detect- postdoctoral fellowship training in applied physics ing copy number alterations from whole at Harvard University’s Broad Institute. Dr. Basu’s Other Section highlights in FY 17 include the • Predicted susceptibility to tuberculosis based exome and genome sequencing (Silva, research focuses on the multi-disciplinary fields of successful acquisition of a NIH R01 to support on gene expression profiling in dendritic cells Chen et al., Genome Biology, 2017) microfluidics, genomics, and nano- and bio-mate- Dr. Gilad’s efforts to characterize regulato- (Gilad, et al., Science Reports, 2017)

28 Department of Medicine 2017 Annual Report 29 Research efforts by GPM faculty and staff continue to be supported by a variety of external Highlights, Accomplishments, sources, including NIA, HRSA, and the Coleman and Impactful Discoveries: Foundation. Dr. Thompson is leading a HRSA- funded Geriatric Workforce Enhancement • Megan Huisingh-Scheetz, MD & Kather- Program which created the South Side Healthy ine Thompson, MD — Recipients of the BSD Aging Resource Experts (SHARE) Network Distinguished Leaders in Program Innovation section of to improve health for older adults across (Junior Award) in recognition of Successful Chicago’s South Side. Through this program, Aging and Frailty Evaluation (SAFE) Clinic Dr. Thompson and the geriatrics faculty provide Dr. Lauren Gleason geriatrics training to ambulatory and skilled • Katherine Thompson, MD — Elected to the Dr. Stacie Levine nursing facility health professionals through Academy of Distinguished Medical Educators geriatrics Extension for Community Healthcare Outcomes (ECHO). Dr. Huisingh-Scheetz continued her • Megan Huisingh-Scheetz, MD — Received its key programs: Frailty (Successful Aging for work on predicting early frailty biomarkers to the Presidential Poster Award from the Ameri- Frail Elders [SAFE] Clinic), Geriatric Pharma- advance understanding of the role of activity and can Geriatrics Society cy, SOCARE Geriatric-Oncology Clinic, and sedentary behavior in the pathophysiology and and palliative Palliative Medicine. In FY 17, Lauren Gleason, treatment of frailty as part of her NIH K23 award. • Lauren Gleason, MD — Appointed to the MD, MPH, assistant professor of medicine Young Professionals Advisory Group for the became the newest member of the GPM faculty. In the educational realm, Dr. Kostas was award- American Geriatrics Society Dr. Gleason’s primary interests in geriatrics are ed two grants funded by the Academy of Dis- in fractures, frailty, delirium, and polypharmacy tinguished Medical Educators and the Medical • Monica Malec, MD — Participated in the medicine as well as having expertise in geriatric surgi- Education, Research Innovation, Teaching, and American Academy of Hospice and Palliative cal co-management models. She has joined Scholarship (MERITS) program. With support Medicine Ascend Leadership Forum and was Teresita Hogan, MD, to improve the evaluation from these awards she created a successful lon- named by Castle Connolly as a Top Doctor in Nationally, Dr. Levine is an active member of the and management of older adults who fall, and gitudinal, interprofessional pharmacy experience Chicago and Exceptional Women in Medicine American Geriatrics Society and fellow of the is also a partner on the Geriatrics Emergency for Pritzker medical students. Shellie Williams, In August 2017, Stacie Levine, MD, Professor of Medicine, American Academy of Hospice and Palliative Department Collaborative (GEDC), a project MD, continues to direct the Geriatrics and Aging During the past year, Section of Medicine (AAHPM) where she served as the funded by the John Hartford and Gary and through Transitional Environments (GATE) Pro- was appointed as chief of the Section of Geriatrics & Palliative chair of the fellowship director’s task force com- Mary West Foundations, with a goal of estab- gram, a longitudinal curriculum in geriatrics for Geriatrics & Palliative Medicine mittee and member of the Curricular Milestones lishing GED guideline initiatives to improve medical students. In post-graduate education, investigators: Medicine (GPM). Dr. Levine received her MD from Rush Medical and Entrustable Professional Activity work elder care in the emergency department. the Hospice and Palliative Medicine Fellowship group. She is also a member of the Academic continues to attract excellent candidates from • Described frailty evaluation and management College in 1997 followed by internal medicine residency and Palliative Medicine Council and Workforce and The inpatient and ambulatory Oncology across the country with over 60 applicants in guidelines for oncologists in order to improve Leadership Development Strategic Coordinating Palliative Medicine Programs continue to FY 17, and is now under the direction of outcomes for this vulnerable population geriatrics fellowship training at Mount Sinai Medical Center, NY. Committee. Dr. Levine has earned recognition as grow steadily under the direction of Monica Dr. Charles Rhee, MD. The Geriatrics Fel- (Huisingh-Scheetz, et al., Journal of Geriatric a Castle Connolly and Chicago Magazine’s Top Malec, MD, who is leading the first integrated lowship Program, led by Dr. Thompson, Oncology, 2017) In 2001 she arrived at the University of Chicago as a research Doctor. She is currently Co-PI for a multi-cen- mesothelioma program in palliative medicine also attracted two top graduates from tered regional palliative medicine education pro- in the United States. The Cardiac Palliative the internal medicine residency class. • Identified differences in estimation of surgical fellow in geriatric medicine and joined the faculty in 2002. gram with Rush University engaging 22 hospitals Service (Charles Rhee, MD–Director) has risk of lung resection related to physician and across the greater Chicago-land area, and fund- seen growth as it provides support to patients Professor: Clinical Associates: patient gender (Ferguson, Huisingh-Scheetz, ed by the Coleman Foundation ($1.4 million). with advanced heart failure, including patients Stacie Levine, MD (Chief) Selina Chow, MD Thompson, et al., Annals of Thoracic Surgery, Dr. Levine successfully led efforts to build a fellowship programs in geriatrics and palli- She has published numerous book chapters with left ventricular assist devices. Within the James Wallace, MD 2017) clinical palliative medicine program in order ative medicine. These programs are consis- and manuscripts in top journals in her field. outpatient programs, the nationally recognized Associate Professor: to improve the clinical care for our seriously tently recognized as among the best in the SAFE Clinic (Katherine Thompson, MD, and Daniel Brauner, MD Secondary Appointments: • Provided insights into role of verbal and non- ill patients. This accomplishment was recog- Midwest, and continue to attract excellent Dr. Levine’s vision for the Section includes Megan Huisingh-Scheetz, MD–Co-Directors) Stacy Lindau, MD verbal communication in physicians’ commu- nized internally through renaming the Section candidates from across the country. As a growth in the research programs including continues to provide comprehensive geriatric Assistant Professors: Tamara Konetzka, PhD nication with older patients (Gorawara-Bhat, of Geriatrics to the Section of Geriatrics and clinician educator she has been recognized the creation of an Aging Research Institute, assessment and frailty evaluations for vul- Lauren Gleason, MD Erin Zahradnik, MD et al., Patient Education & Counseling, 2017) Palliative Medicine in 2008. She also success- for her contributions with appointments as growth in the clinical programs including an nerable older patients as well as serve as a Megan Huisingh-Scheetz, MD, and patients’ perceptions of hormone therapy fully led an initiative to develop a Supportive a fellow in the Academy of Distinguished on-site geriatrics assessment clinic in the platform for research and teaching efforts. The MPH Section Administrator: in recurrent prostate cancer in older patients Oncology inpatient service in collaboration Medical Educators and as a faculty scholar in DCAM and other satellite clinics, and enhanc- Specialized Oncology Care & Research in the Tia Kostas, MD Bradford Lane (Gorawara-Bhat, et al., Journal of Geriatric with the Section of Hematology/Oncology that Bucksbaum Institute for Clinical Excellence. ing the fellowship programs with additional Elderly (SOCARE) clinic (Selina Chow, MD, and Monica Malec, MD Oncology, 2017) focuses on supporting patients and families This year Dr. Levine was selected to partici- mentoring and research opportunities. James Wallace, MD–Co-Directors) remains an Michelle Martinchek, MD+ +New FY 18 faculty with advanced solid tumor malignancies. pate in the Hedwig van Ameringen Executive integral centerpiece to geriatric oncologic care Charles Rhee, MD • Described the impact of a multi-centered Leadership in Academic Medicine (ELAM) As the largest independent geriatrics & palliative in Chicago. New in FY 17 was the creation of Katherine Thompson, MD interdisciplinary training program in pal- In the educational realm, Dr. Levine directed leadership program for women in medicine. medicine section/division in Chicago, GPM an APN led, Polypharmacy in Late Life (PILL) Sandy Tun, MD+ liative medicine (Levine, et al., Journal of the development of two nationally-recognized continues to achieve substantial success across Clinic under the direction of Tia Kostas, MD. Shellie Williams, MD Pain and Symptom Management, 2017)

30 Department of Medicine 2017 Annual Report 31 outpatient visits and continued to expand the and continues to grow its multisite portfolio through Unique Highlights, cellular and stem cell transplant program (Michael this Personalized Cancer Care Consortium. Accomplishments, and Bishop,MD - Director), with 164 patients treated. Discoveries: Cellular therapies, and CAR-T cell therapy spe- Under the direction of Kenneth Cohen, MD and cifically, is a rapidly emerging treatment modality Olwen Hahn, MD the Section continues to run that utilizes autologous T-cells with genetically a highly successful fellowship program. The 7 • Philip Hoffman, MD – Appointed to serve on modified receptors targeting tumor antigens fellows selected annually typically come from the the FDA’s Oncologic Drugs Advisory Committee that has been investigated by this program. highest ranked residency training programs. For and selected by the Pritzker School of Medicine The Section is now poised to be one of the first FY 17, over 80% of the graduating fellows are Class of 2017 as a recipient of the Favorite centers in the Midwest to have this complex starting their careers with an academic affilia- Faculty Award for the 7th consecutive time. Dr. Walter Stadler treatment available as a standard of care. Under tion and one is extending her laboratory training the direction of Blase Polite, MD, the Section as a physician scientist, reflecting success in • Joseph Baron, MD – Appointed as section of continued its effort toward implementing stan- the strategic goal of training future leaders in a Bucksbaum Institute for Clinical Ex- dardized care pathways as well as value based oncology. Several fellows and junior faculty cellence Senior Faculty Scholar care models. This capability and standardization have earned external training awards in FY 17. has been critical to the successful negotiation During the past year, Section of of a number of insurance contracts by UCM. In hematology/ regard to value based care models, the Sec- Professors: tion implemented the Medicare Oncology Care Walter Stadler, MD (Chief) Satyajit Kosuri, MD Hematology/Oncology investigators: Model and continues to support value based Michael Bishop, MD Chih-Yi (Andy) Liao, MD+ contracts with Aetna and Blue Cross and Blue Suzanne Conzen, MD Tanguy Lim-Seiwert, MD • Conducted a series of translational studies Shield. This effort has involved a large cadre of Christopher K. Daugherty, MD Hongtao Liu, MD, PhD exploring the hypothesis that the glucocorticoid oncology individuals from the Department and institution M. Eileen Dolan, PhD Jason Luke, MD receptor is a therapeutic target in a variety of resulting in growth and improved utilization of Gini F. Fleming, MD Peter O’Donnell, MD malignancies, including breast, ovarian, and the Supportive Care Unit. In FY 17, the Support- Thomas F. Gajewski, MD, PhD Akash Patnaik, MD prostate cancers ( Szmulewitz, Conzen, et al., ive Care Unit (Chris Daugherty, MD and Stacie Lucy A. Godley, MD, PhD Alexander Pearson, MD, PhD+ Molecular Cancer Therapeutics, 2017 and Under the direction of Walter Stadler, MD the Section of Hematology/Oncology continues to Levine, MD - Co-directors) evaluated an average Harvey M. Golomb, MD Peter Riedell, MD Conzen et al., Molecular Cancer Research, 2016) enjoy national and international prominence for its impactful contributions to the clinical, research of 290 patients monthly which has helped the Philip Hoffman, MD Manish Sharma, MD UCM retain and negotiate a number of insurance Andrzej Jakubowiak, MD, PhD Russell Szmulewitz, MD • Showed that the density of immunogenic and educational missions. Among the many accomplishments this past year, most notable were contracts and resulted in quality care certification Hedy L. Kindler, MD Yonglan Zheng, PhD* antigens does not explain the presence or the successful initiation of value based care through the Medicare Oncology Care Model and under the QOPI program sponsored by ASCO. Richard A. Larson, MD absence of the T-cell–inflamed tumor micro- Michelle M. Le Beau, PhD Instructors: environment in melanoma (Spranger, Luke, et growth of immunotherapy clinical research, which has begun to realize a long sought connection The Section maintains a very strong and suc- Mark Lingen, DDS, PhD Emily Curran, MD al., Proceedings of the National Academy of of harnessing the immune system for cancer therapy, and which in turn strengthens the connec- cessful program in basic, translational and clinical Yusuke Nakamura, MD, PhD Steven Maron, MD+ Sciences of the United States of America, 2016) research. In FY 17 section faculty were awarded Olufunmilayo Olopade, MD Randy Sweis, MD+ tions between cancer care and research with the powerful work ongoing in the Department and over $20M in total costs grant funding coupled Jyoti Patel, MD • Made important contributions to understanding the institution in basic immunology, infectious disease, and the microbiome. with an additional $19.2 M in clinical trial earnings. Mark J. Ratain, MD Clinical Associates: the immunobiology of the T-cell reaction against Specifically, Akash Patnaik, MD garnered a number Sonali M. Smith, MD Andrea Amico, MD tumors (Saloura, Nakamura, Vokes, Lingen, Sei- of new grants to augment his prostate cancer Wendy Stock, MD Sunila Narula, MD wert, et al., Clinical Cancer Research, 2017 and Dr. Peter Riedell In FY 17 three new faculty were welcomed to as the recipient of the 2017 American Society research; Suzanne Conzen, MD was the recipient Everett Vokes, MD Brooke Phillips, MD Inoue, Nakamura, et al., OncoImmunology, 2016 ) Dr. Satyajit Kosuri the Section: Peter Riedell, MD, Satyajit Kosuri, for Clinical Oncology’s (ASCO) Humanitarian of a large Prostate Cancer Foundation award to Amittha Wickrema, PhD Murtuza Rampurwala, MD Dr. Emily Curran MD, and Emily Curran, MD. Dr. Riedell, assistant Award and Thomas Gajewski, MD, PhD was investigate the use of selective glucocorticoid re- Shayan Rayani, MD • Developed novel approaches to prostate professor of medicine, focuses his efforts on the the recipient of the National Cancer Institute ceptor antagonists in castration-resistant prostate Associate Professors Ardaman Shergill, MD cancer immunotherapy, a tumor type that development of innovative treatments for lympho- Distinguished Investigator Award. Dr. Gajewski cancer; Michael Thirman, MD was the recipient Andrew Artz, MD Grace Suh, MD has not been highly responsive to the re- ma with an emphasis on cellular and immunother- was also named the AbbVie Foundation Profes- of a new NIH R01 to study the instructive role of Joseph M. Baron, MD Samir Undevia, MD cently developed PD1 pathway inhibitors apies. Dr. Kosuri, assistant professor of medicine, sor. Sonali Smith, MD, was named the Elwood V. MLL fusion proteins in lineage determination and Kenneth Cohen, MD (Patnaik, et al., Cancer Discovery, 2017) interests lie in the area of stem cell transplantation Jensen Professor for her outstanding contributions leukemogenesis; and Lucy Godley, MD, PhD and Olwen Hahn, MD Part Time Faculty for patients diagnosed with acute leukemia, to lymphoma therapeutics and Wendy Stock, Amittha Wickrema, PhD each were awarded grants Olatoyosi M. Odenike, MD Mark Kozloff, MD • Identified a number of novel mutations pre- myelodysplastic syndrome and myelofibrosis. MD was the recipient of the Biological Sciences from the Leukemia and Lymphoma Society. Clinical Rita Nanda, MD disposing patients to hematologic and other Dr. Curran, pathway instructor, is investigating Division(BSD) Distinguished Clinician Award. research in the Section was similarly active with Blase N. Polite, MD Section Administrator malignances and investigated the biologic mechanisms of immune resistance in leukemia nearly 320 active therapeutic clinical trials conduct- Angela Stoddart, PhD* Jerry Schissler mechanisms by which these mutations have by utilizing murine models to identify therapeutic In the clinical arena, the Section was once again ed and enrollment of over 791 patients annually. Michael J. Thirman, MD their deleterious effects. (Godley et al., Blood, strategies to enhance anti-leukemia immunity. recognized by USNWR as one of the top cancer Under the direction of Dr. Gajewski and Jason *Research Appointee Track Faculty 2017 and Godley, Churpek, Larson, et al., programs in the nation (August 2017) and over Luke, MD, the Section continues to be a national Assistant Professors +New FY 18 faculty Biology and Blood Marrow Transplant, 2016) Also in FY 17 several Section faculty were rec- two dozen faculty were named as “Top Cancer leader in immunotherapy clinical trials. The Section Daniel Catenacci, MD, PhD ognized nationally for their outstanding academic Doctors” by Chicago magazine (January 2017). expanded its clinical research into the broader Jane Churpek, MD contributions: Funmi Olopade, MD was named In FY 17, the Section conducted over 43,000 UCM based network at Silver Cross, Orland Park Justin Kline, MD

32 Department of Medicine 2017 Annual Report 33 Highlights, Accomplishments, and Discoveries:

• Robert Gibbons, PhD — Appointed as an Advisor to David Shulkin, MD, the Secretary of Veterans Affairs

• Jeanne Farnan, MD — Recipient of the Pritzker School of Medicine section of Dr. David Meltzer L.D.H. Wood Pre-Clerkship Teaching Award and Favorite Faculty Award and the 2017 Department of Medicine Clinical Teacher of the Year Award hospital • Cheng-Kai Kao, MD — Elected as a Fellow of the Society of Hospi- tal Medicine and of the American College of Physicians medicine During the past year, Section of Hospital Medicine investigators: Dr. Joyce Tang – Recipient of the Department of Medicine’s 2017 Janet one-year follow-up for all 2,000 patients, receipt of CONsorTium) to enhance the application of per- Rowley Research Day Best Abstract Award in Health Services Research • Provided insights into the educational funding from the Donoghue Foundation to extend sonalized medicine targeted to African Americans impact of the electronic health record (Shan- Under the leadership of David Meltzer, MD, PhD, the Section of follow up to 3 years, and the launch of the Robert and a new grant from the Richmond Foundation Professors: Clinical Associates: non, Farnan, Journal of Graduate Medical Wood Johnson Foundation’s funded Comprehen- to launch a 5-year study assessing the effects of David Meltzer, MD, PhD (Chief) Hatem Al Kassem, MD Education, 2017) Hospital Medicine is recognized for its strong and integrated pro- sive Care Community and Culture Program to better free dental care on oral and systemic health for Robert Gibbons, PhD Rizma Bajwa, MD+ engage CCP patients by screening for unmet social older persons. Dr. Meltzer was also the recipient of Shalini Reddy, MD Nicole Bendin, MD • Conducted a national longitudinal survey grams in clinical care, research, and education. Utilizing innovative needs, addressing those needs through the ser- a National Institute on Aging R21 that will utilize a Grace Berry, MD of medical students’ intentions to prac- vices of a community health worker, and engaging national database linked with Medicare claims data Associate Professors: Christina Boutsicaris, MD+ tice among the underserved and found care models, Section faculty care for some of the most medically patients in arts and cultural programming. Another to develop a novel big-data screening tool to identify Jeanne Farnan, MD Bryan Campbell, MD that growing up in medically underserved ambulatory-based initiative was the establishment and reduce cost-related medication non-adherence. Kwang Jin Choi, MD settings and a strong sense of calling and complex patients admitted to the University of Chicago Medicine of an International Patient Program at 150 E. Huron Assistant Professors: Tatvam Choksi, MD other factors were associated with intentions offsite practice (Cheng Kai Kao, MD–Director). Hospital Medicine faculty continue to be ac- Brian Callender, MD Anne Cramer, MD to practice medicine in underserved areas (UCM). The Section of Hospital Medicine is also known for its in- tively engaged in teaching and training the next Matthew Cerasale, MD+ Parin Desai, MD (Yoon, et al., Academic Medicine, 2017) In FY 17, the Section welcomed Ishanu Chatto- generation of physicians and physician scientists Ishanu Chattopadhyay, PhD Anubhan Ganjoo, MD novative research that is advancing the frontiers of clinical practice padhyay, PhD, assistant professor of medicine, at the medical school, residency and at the post Thomas Chen, MD+ Lizhu Gao, MD • Developed a new set of recommendations to the faculty. Dr. Chattopadhyay is an expert in graduate level. Leadership roles in the medical Anton Chivu, MD Sarah Haroon, MD to improve the quality of cost-effectiveness and training future generations of physicians in hospital medicine. machine learning and predictive analytics whose school include Assistant Dean for Curricular Dana Edelson, MD Christine Jun, MD analyses (Sanders, Ganiats, Meltzer, et al., research is focused on the theory of unsuper- Development and Evaluation (Jeanne Farnan, Cheng-Kai Kao, MD Navett Kaur, MD JAMA, 2016) In FY 17, the Section continued to enhance its vised machine learning, the interplay of stochastic MD), the Global Health Scholarship and Dis- V. Ram Krishnamoorthi, MD Ehtasham Khattak, MD Dr. Ishanu Chattopadhyay growing inpatient programs at UCM by developing processes and formal language theory in exploring covery track (Brian Callender, MD), Director and Shannon Martin, MD Sladjana Mitric, MD+ • Demonstrated an association between and implementing a plan led by Marius Chivu, MD, the limits of automated learning algorithms, and the Assistant Program Director of the Internal Medicine Elizabeth Murphy, MD+ Tokhanh Nguyen, MD in-hospital critical illness events and Director of Clinical Operations, that expanded philosophical and mathematical underpinnings of Residency Program at Mercy Hospital (Shalini Gregory Ruhnke, MD Dragana Radovanovic, MD outcomes in patients on the same ward clinical coverage to include oncology hospitalists the question of inferring causality from data. His Reddy, MD and John Yoon, MD), director of the Milda Saunders, MD Edwin Rosas, MD (Kang, Edelson, et al., Critical Care and staff new services. Staffing these new services current work is supported by a new grant from the MD/PhD Program in the Social Sciences and chair Andrew Schram, MD+ Chang Yang, MD Medicine, 2016; Churpek, Edelson, et required recruiting 15 new clinicians, which was Defense Advanced Research Projects Agency. of the Committee on Clinical and Translational Joyce Tang, MD Madhu Yarlagadda, MD al., Journal of Hospital Medicine, 2016) made possible by a highly structured approach Science (David Meltzer, MD, PhD). Dr. Farnan was Audrey Tanksley, MD to identifying, screening, interviewing, and hiring The Section’s research portfolio consisted of featured as a master teacher in a book on teaching Anshu Verma, MD+ Section Administrator: new clinicians. FY 17 was also a major year for the nearly $5.0 million in extramural funding in FY 17. inpatient medicine by the University of Michigan’s John Yoon, MD James Skish (Interim) Section’s Medicare-funded Comprehensive Care In addition to the new CCP funding noted above, Dr. Sanjay Saint. Drs. Joyce Tang and Audrey Physician (CCP), a program that seeks to improve major new funding was awarded to Dr. Meltzer from Tanksley led the CCP physicians in developing Instructor: +New FY 18 faculty care and lower costs through continuity of care. FY a NIH U54 award supporting the ACCOuNT (Afri- a well-received new longitudinal clinical expo- Micah Prochaska, MD 17 highlights for the CCP include the completion of can American Cardiovascular Pharmacogenomics sure curriculum for first year medical students.

34 Department of Medicine 2017 Annual Report 35 days a week. In FY 17, the Section implemented Chicago. Other research highlights include funding an outpatient antibiotic therapy program, a joint for Dr. Ridgway from Gilead Sciences to develop Highlights, Accomplishments, effort between the antimicrobial stewardship rapid response team and algorithmic HIV post-test and Discoveries: program (ASP), the pharmacy and the Section counseling in high-volume settings and funding from to provide follow up of patients discharged on IV the Chicago Department of Public Health to utilize • John Schneider, MD — Elected as a Bucks- antibiotic therapy. The ASP continues to make informatics to identify patients with HIV who are out baum Institute for Clinical Excellence Senior great progress in assuring appropriate antimicrobi- of a care network. Dr. Ridgway was also awarded Faculty Scholar and nominated as the City of section of al use at UCM, not only through day to day review a CFAR administrative supplement to examine the Chicago’s representative for the International of antibiotic usage, but also innovative education barriers to PrEP (pre-exposure prophylaxis) against Association of Physicians in AIDS Care and efforts aimed at both physicians and patients. HIV infection among African American Women the UN AIDS fast-track city initiative. Dr. David Pitrak In quality initiatives, the UCM has continued to in Chicago. Mai Pho, MD was awarded funding meet all its goals with respect to hand hygiene, from CFAR administrative supplement for Prelink • Mai Pho, MD — Completed her term as the infectious central line associated bloodstream infections, (Pre-Release Linkage to HCV, HIV, and Addiction Interim Chief Medical Officer for the Illinois and catheter associated UTIs, and continues Services), a project that seeks to implement a Department of Public Health to combat C. difficile infection in the hospital. coordinated management model of pre-release assessment, screening, and linkage to care in a • Renslow Sherer, MD — Delivered the Harry Within the Section, the Chicago Center for HIV rural jail setting. She was recently awarded a NIH F. Dowling, MD Memorial Lecture at the diseases and Elimination (John Schneider and David Pitrak, UG3 grant to inform and implement methods to University of Illinois at Chicago entitled “Pros- co-directors) provides care for HIV-infected end the transmission of HIV, HCV, and STDs and pects for HIV Elimination in Chicago” patients, as well as screening, prevention edu- provide access to clinical services for people who cation treatment for pediatric HIV patients who inject drugs in rural communities in Illinois. In clinical are transitioning to adult care and post-partum research, Kathleen Mullane, MD continues to During the past year, global health care for HIV-infected women and their exposed conduct a number of clinical trials of new antimicro- Section of Infectious Diseases children. With uninterrupted funding from the bial agents, with many of her studies benefiting the Chicago Department of Public Health (CDPH) immunocompromised patients in our leukemia, stem and Global Health investigators: since 2011, Dr. Pitrak continues to focus his efforts cell transplant, and solid organ transplant programs. Dr. Titus Daniels, on expanded HIV testing and linkage to care • Studied the time course of microbial coloniza- Under the direction of Dr. David Pitrak, the Section of Infectious Dr. Jonathan Lio, and (X-TLC) for disproportionately affected populations In the educational arena, the Infectious Diseases tion in the Center for Care and Discovery and Diseases and Global Health has seen continued growth and Dr. Moira McNulty in healthcare settings at UCM and at 12 other and Global Health Fellowship Program continues the interplay between the hospital environ- sites on the south and west sides of Chicago. The to attract outstanding fellows, the majority from ment and patients in colonized environments expansion of clinical activities, clinical trials, research, educational impact of this program has led to an increase in the Department’s internal medicine residency (Lax, Weber, Landon, et al., Science Transla- activities, and service to the institution. The Section is currently early stage disease diagnosis and reduced early program. Within the Pritzker School of Medicine, tional Medicine, 2017) AIDS-related deaths within 1 year of diagnosis. courses on global health and HIV infections have comprised of 14 faculty who have special expertise in all areas HIV testing will be expanded at UCM in FY 18. been incorporated into medical school curriculum. • Reported on the first US cases of Candida of clinical infectious diseases, as well as education and clinical The Wuhan University Medical Education Reform auris, a multi-drug resistant fungal pathogen In FY 17, the Section’s research portfolio totaled (WUMER) Project, (Renslow Sherer, MD–Direc- that is emerging worldwide (Vallabhaneni, research in infectious diseases, public health, and global health. over $6.0M. Dr. Schneider continues to have sig- tor) is now in its ninth year and is funded through Landon, Ridgway, et al., American Journal of Efforts in public health, particularly HIV care and prevention, nificant extramural funding including 5 NIH funded 6/30/2019. The highly successful effort continues Transplantation, 2017) awards. New grants this year included a NIH R01 to provide faculty development programs, under- connect out into communities on both the south and west sides to investigate relationships between GPS-defined graduate curriculum improvement, and residency • Provided new insights into social networks of Chicago that are disproportionately affected by HIV with vul- activity space neighborhoods, social and sexual training at Wuhan University and has been lauded and their importance in HIV prevention efforts networks, and HIV pre-exposure prophylaxis among by the China Higher Education Association. (Schneider, et al, Network Science, 2016) nerable populations that include minorities and members of the young Black men who have sex with men in the LGBTQ community. The Section also has programs to combat Chicago metropolitan area. Dr. Schneider was also • Showed that recurrence rates of Clos- awarded a NIH UO1 to develop and implement a tridium difficile infection were lower with HIV, HCV, and drug addiction across the state, and internation- residency training through curricular development. health care engagement intervention to increase Professors: Assistant Professors: surotomycin with higher sustained clinical ally, with global connections in HIV prevention work in India and Dr. McNulty’s interests are focused on investi- and strengthen access to care among men and their David Pitrak, MD (Chief) Emily Landon, MD response rates compared with vancomycin gating the effectiveness of different HIV testing networks. Under the direction of Dr. Schneider, and Kathleen Mullane, DO, Pharm D Jonathan Lio, MD (Mullane, et al., Journal of Antimicrobial Greece, and efforts to reform medical education in China. strategies and the unique populations at risk for with co-directorship by Dr. Pitrak and participation Kenneth Pursell, MD Jennifer Pisano, MD Chemotherapy, 2016) and determined the HIV infection identified by those strategies. by Jessica Ridgway, MD, the Section continued Renslow Sherer, MD Mai Pho, MD efficacy and safety of isavuconazole for In FY 17 Titus Daniels, MD, joined the Section antibiotic therapy program (OPAT). Jonathan Lio, its involvement in the Third Coast Center for AIDS Stephen Weber, MD Jessica Ridgway, MD treatment of mucormycosis (Marty, Mullane, as associate professor of medicine and vice MD, assistant professor of medicine, and Moira The Section continues to provide outstanding Research (CFAR) partnership with Northwestern et al., Lancet Infectious Diseases, 2016) president and chief ambulatory medical officer McNulty, MD, Coggeshall instructor, also joined consultative services 24/7 to ensure optimal and University, the AIDS Foundation of Chicago, the Associate Professors: Coggeshall Instructor for University of Chicago Medicine (UCM). In the Section in FY 17. Dr. Lio currently serves as timely management of serious infectious diseases Chicago Department of Public Health, the Alliance Jean-Luc Benoit, MD Moira McNulty, MD addition to his large administrative role, Dr. Daniels the co-director of residency training for the Wuhan and has invested a large amount of manpower of Chicago Community Health Systems, and the Titus Daniels, MD is an active clinician and director of the Section’s University Medical Education Reform Project. His serving the oncology and transplant programs by Center on Halsted, to reduce the very high rate of John Schneider, MD Section Administrator ambulatory programs, including the outpatient interests are focused on improving the quality of running an immunocompromised host service, 7 new HIV infections among young minority MSM in Elizabeth Fitzgerald

36 Department of Medicine 2017 Annual Report 37 DO - Medical Director) and the Stony Island mal dominant polycystic kidney disease (Arlene Hemodialysis Unit (Nichole Stankus, MD - Medical Chapman, MD - PI, Bharathi Reddy, MD - Co-PI). Highlights, Accomplishments, Director) continue to deliver excellent patient and Discoveries: care. The Stony Island and Kenwood facilities In the educational realm, the Nephrology Fellow- report a relative death ratio of 0.69 compared ship Program boasts a successful match of 4/4 fel- to the national average. With regard to national lowship spots for FY 18 at a time when 40% of the • Michelle Josephson, MD – Appointed to performance measures, all four units rank in the nation’s training slots were left unfilled. The Ne- the Policy and Advocacy Committee of the top 5 in their regions, and Stony Island unit ranks phrology Fellowship Program is a joint University of American Society of Nephrology and the Data in the top 20% nationally. The Kenwood Facility Chicago-NorthShore University effort. The second Safety and Monitoring Board for the University has received, for the second consecutive year, year of the fellowship program has been reorga- of Pennsylvania Thinker Study (Open labeled 5 out of 5 stars on the CMS created star-rating nized to provide intensive training in specific areas trial of MK-5172 and MK-8742 for treatment of Dr. Arlene Chapman system. Dr. Stankus with Stony Island Dialysis of nephrology to allow all fellows to become sub- hepatitis C negative patients who receive kidney Unit was awarded the “DaVita Core Value Award ject matter experts in a particular subspecialized transplants from hepatitis C positive donors). of Team” by the DaVita Physician Council. area of Nephrology. The second year tracks pro- gram has produced meaningful research with three • Jay Koyner, MD – Reappointed to a two year The Section of Nephrology is proud of its diverse abstracts presented at Department of Medicine’s term as Chair of the American Society of Ne- bench, translational and patient oriented investi- 2017 Research Day and two abstracts submitted phrology Critical Care Nephrology Pre-Course. section of gations in polycystic kidney disease, acute kidney to the American Society of Nephrology annual injury, epithelial cell transport, growth, and gene meeting and two publications. In addition, one fel- • Tipu Puri, MD, PhD – Awarded the Harold & expression, and the pathophysiology of kidney low successfully completed his MSCS through his Molly Schwartz Founders Lifetime Achievement stone formation. New in FY 17 was the addition of work in the Stones and Bones track focusing on al- Award by the National Kidney Foundation of Illi- two NIH subcontracts (Arlene Chapman, MD - PI), buminuria, nephrolithiasis and metabolic bone dis- nois and was named as a Bucksbaum Institute nephrology the first with the University of California, Davis, a ease. Dr. Koyner has developed a new educational for Clinical Excellence Senior Faculty Scholar study of metabolomics discovery of biomarkers for track for fellows starting in FY 18 that focuses on disease progression and response to therapies. AKI-critical care nephrology and onco-nephrology. • Bharathi Reddy, MD – Re-elected to the development and validation of Nephrocheck, The second is a subcontract with the University of the Medical Review Board of the ESRD a clinical biomarker test used to predict the future Kansas as part of the Consortium for Radiologic Dr. Ko has begun a new national TREKS (Tutored Network 10 for a second 3 year term. The Section of Nephrology has a distinguished history in the development of acute kidney injury (AKI) in ICU pa- Imaging Studies of Polycystic Kidney Disease Research and Education for Kidney Scholars) study of and potential treatments for kidney disease. Under the tients that became available at University of Chicago (CRISP), a unique, longitudinal, observational program in conjunction with the American Society • Nicole Stankus, MD – Appointed as Medicine in May 2017. Mary Hammes, DO continues cohort study of 241 autosomal dominant polycystic of Nephrology for medical students interested panel member of the CMS Technical direction of Arlene Chapman, MD, Professor of Medicine, the her collaborative efforts with interventional radiology kidney disease (ADPKD) patients that began in in careers in nephrology. In July 2017, students Expert Panel for the ESRD Dialysis Fa- to standardize measurement of venous stenosis in 2000 and was competitively renewed in FY 17. The travelled to Chicago from the United States cility Compare (DFC) Star Ratings. Section had a very productive and successful year with many patients requiring interventional procedures to repair Consortium consists of researchers at University and Canada and spent a week participating in arteriovenous fistulas and grafts and is developing of Alabama, University of Chicago, Emory Universi- research and clinical experiences spanning a accomplishments to be proud of including the recruitment of prediction models for successful outcomes after ty, University of Kansas Medical Center, Mayo Clin- range of nephrology topics. The students will Rita McGill, MD, associate professor of medicine, an expert in angioplasty. In FY 17, the Section established a ic, and University of Pittsburgh. CRISP continues continue have access to ongoing mentorship Glomerulonephritis Clinic (Patrick Cunningham, to define the natural history of ADPKD and to dis- and participation in national ASN meetings. end stage renal disease, vascular access and their associated MD - Director) to serve as a referral clinic for a variety cover prognostic biomarkers in early Disease that of patients with glomerulonephritis, focusing on can accurately predict long-term renal outcomes. complications. Dr. McGill serves as the Medical Director for the those who are APOL1 genotype positive. The Renal Hatim Hassan, MD, PhD continued his NIH funded Professors: Assistant Professors: Transplantation Program (Michelle Josephson, MD investigations on calcium oxalate kidney stones Arlene Chapman, MD (Chief) Kristin Bergsland, PhD* Section’s 5th outpatient dialysis center, the Park Manor Unit that - Director) is working closely with the leadership of where he recently identified a family of Oxalobacter Fredric Coe, MD Patrick Cunningham, MD opened in September 2017. the new Transplant Institute and has successfully formigenes-derived proteins, represented by Michelle Josephson, MD Hatim Hassan, MD, PhD developed the Champion Kidney Donor Program to OF301, to be one of the major factors stimulating Elaine Worcester, MD Benjamin Ko, MD • Kristin Bergsland, PhD – Recipient of Within the clinical area, the Renal Ambulatory Care identify motivated donors for renal transplantation. oxalate transport by human intestinal Caco2-BBE Bharathi Reddy, MD the Best Abstract Award (Translational Clinic (Anna Zisman, MD - Director) increased its Orly Kohn, MD, in conjunction with Paul Chang (C2) cells (Hassan, et al., Journal of the American Associate Professors: Pratik Shah, MD+ Research) at the Department of Medi- visit volume by over 10% in FY 17 while reducing MD (Department of Radiology), continues to train Society of Nephrology, 2017). This discovery has Mary Hammes, DO Anna Zisman, MD cine 2017 Janet Rowley Research Day. wait times so that the next available appointment is clinical nephrology fellows on both transplant and a significant potential for clinical application in the Orly Kohn, MD always under one week. Patient satisfaction surveys native kidney biopsy through didactic sessions and prevention and/or treatment of hyperoxaluria. The Jay Koyner, MD Clinical Associate: • Patrick Cunningham, MD and Anna Zisman, have remained excellent and reorganization of the specialized training within the simulation center. Pathogenesis of Calcium Nephrolithiasis (Elaine Rita McGill, MD John Asplin, MD MD – Named as Bucksbaum Institute for Clinical outpatient clinic has allowed for better patient flow Worcester, MD - Principal Investigator) NIH P01 Tipu Puri, MD, PhD Excellence Associate Junior Faculty Scholars. and care for kidney disease patients. The Acute The four University of Chicago-led Davita-owned studying idiopathic hypercalciuria and renal stone Nicole Stankus, MD Section Administrator: Dialysis Unit (Jay Koyner, MD - Director) success- outpatient dialysis units, the Kenwood Chronic formation, has been competitively renewed for five Elizabeth Fitzgerald During the past year, the Section of Nephrology fully and seamlessly relocated to a 7 chair unit with Hemodialysis (Bharathi Reddy, MD - Medical more years representing its 36th year of contin- have made significant discoveries in the areas a central nurses station and dedicated space for Director), the Home Dialysis/Chronic Peritoneal uous funding. New investigator initiated studies *Research Appointee Track Faculty of urinary acidification, renal imaging, genet- Dr. Rita McGill dialysis specific needs in the Center for Care and Dialysis unit (Orly Kohn, MD - Medical Director), include the effect of renal denervation using +New FY 18 Faculty ic biomarkers for pharmacogenomics and the Discovery(CCD). Dr. Koyner was instrumental in the Woodlawn Hemodialysis Unit (Mary Hammes, Vessix catheterization for severe pain in autoso- physiology of epithelial oxalate transport.

38 Department of Medicine 2017 Annual Report 39 as the largest program in Illinois and received which they regulate innate TLR responses in IPF. competition to determine the top ten outstand- the Center of Comprehensive Care designation Robert Guzy, MD, PhD received a K08 award to ing research accomplishments in the U.S. from the Pulmonary Hypertension Association. study the role of FGF2 in alveolar epithelial repair Dr. McShane reestablished the bronchiectasis following acute lung injury. Matthew Churpek, On the educational front, the Section faculty contin- program, which received the designation of MD, PhD received an R01 grant to study whether ue to distinguish themselves in all domains of teach- national center in the National Bronchiectasis. data from the electronic health record and ing and training. John P. Kress, MD and Edward statistical modeling techniques can be used to Naureckas, MD received the Department’s Medical The Section maintains a successful research identify infected patients who are at high-risk for Resident Teaching Award and Jason Poston, MD program and continued to have a successful year sepsis. In other research highlights, Esra Tasali, was the recipient of the Favorite Faculty Award from securing extramural NIH support. Anne Sper- MD, an internationally recognized expert in sleep the Pritzker School of Medicine graduating students Dr. Gökhan Mutlu ling, PhD received a new R01 to show IRF4+ research was appointed as the Director of the for the fifth time and the Department’s Postgrad- section of dendritic cells promote type 2 inflammation in newly structured Sleep Research Center. Drs. uate Teaching Award. The Section continues to asthma. Imre Noth, MD received a new R01 to Anne Sperling, Cara Hrusch, JP Kress and Bhakti recruit outstanding fellows into our three fellowship identify functional TOLLIP variants associated Patel were selected by the Clinical Research programs; pulmonary and critical care medicine, pulmonary/ with IPF and to delineate the mechanisms by Forum (CRF) as #1 and #2 in its an annual sleep medicine and interventional pulmonary. Professors: Associate Professors: Assistant Professors: Clinical Associate: Gökhan M. Mutlu, MD (Chief) Edward Naureckas, MD Remzi Bag, MD Matthew Churpek, MD, PhD Pamela J. McShane, MD Rekha Vij, MD Edward Garrity, Jr., MD Imre Noth, MD Bohao Chen, PhD* Jessica Cooksey, MD Bhakti Patel, MD+ Jeffrey Glassroth, MD Julian Solway, MD Nickolai Dulin, PhD Yun Fang, PhD Jason Poston, MD Section Administrator: critical care Jesse Hall, MD** Anne Sperling, PhD Kyle Hogarth, MD Laura Frye, MD Philip Verhoef, MD, PhD Elneda Boyd Holly Humphrey, MD Mary Strek, MD Shwu Fan Ma, PhD* Amy Guralnick, MD+ John P. Kress, MD Steven White, MD John McConville, MD Robery D. Guzy, MD, PhD Instructors: *Research Appointee Track Faculty Alan Leff, MD** Septimiu Murgu, MD Robert B. Hamanaka, PhD* Ayodeji Adegunsoye, MD+ +New FY 18 Faculty Babak Mokhlesi, MD Esra Tasali, MD Kristen Knutson, PhD Catherine Bonham, MD **emeritus Under the direction of Gökhan Mutlu, MD, the Section of Pulmonary and Critical Cara Hrusch, PhD Care Medicine continues to be recognized nationally for excellence in clinical medicine, impactful research and innovative educational programs. In FY 17, six Highlights, Accomplishments, and Discoveries: During the past year, Section of Pulmonary/ Critical Care investigators: new faculty joined the Section: Jessica Cooksey, MD, assistant professor, is a • Catherine Bonham, MD — Received • Gokhan M. Mutlu, MD — Appointed as an the American Thoracic Society (ATS) Associate Editor of the American Journal of • Demonstrated an association between physician who has expertise in sleep medicine. Laura Frye, MD, assistant professor, Science and Innovation Award Respiratory Cell and Molecular Biology. in-hospital critical illness events and outcomes in patients on the same ward. is an interventional pulmonologist who directs the complex airway program. (Churpek, Howell, et al., JAMA, 2016) • Edward Garrity, MD — Recipient of the • Edward Naureckas, MD — Named as the Chair Pamela J. McShane, MD, assistant professor, is an expert in bronchiectasis and BSD’s Distinguished Clinician Award of the CF Foundation Guidelines Committee • Demonstrated a key role for KLF2 in endothelial lung transplantation. Philip Verhoef, MD, PhD, assistant professor, is a physician permeability during acute lung injury. (Hamanaka, scientist whose research is focused on the role of the type 2 immune response • Kyle Hogarth, MD — Named as the President • Anne Sperling, PhD — Appointed Associate Vice Kress, Mutlu, Fang, et al., American Journal of of the Society for Advanced Bronchoscopy. Chair for Research for the Department of Medicine Respiratory & Critical Care Medicine, 2017). as a mediator of protection against mortality in sepsis. Catherine Bonham, MD, • Holly Humphrey, MD — Elected member of • Mary Strek, MD — Appointed to the Editorial • Discovered a role for FGF signaling in instructor, is a physician scientist whose research focuses on the interstitial lung Alpha Omega Alpha Board of Directors. Board of Annals of the American Thoracic Society pulmonary fibrosis. (Guzy, et al., Journal diseases and sarcoidosis. Cara Hrusch, PhD, instructor, is a scientist with interest of Biological Chemistry, 2017) • John P. Kress, MD — Recipient of • Philip Verhoef, MD, PhD — Recipient of the • Discovered that Amish environment in understanding the immunologic mechanisms involved in the pathogenesis of the BSD’s Francis Straus Mentorship ASCI Young Physician-Scientist Award provides protection against asthma by Award, and the ATS Assembly on Clinical acute lung injury and fibrosis. engaging and shaping the innate immune Problems 14th Annual Educator Award. • Esra Tasali, MD — Appointed as the Chair response. (Hrusch, Sperling, et al., New Among the clinical programs within the Section, disease (ILD) program (Mary Strek, MD and of Program Committee of ATS Sleep and England Journal of Medicine, 2016). Dr. Catherine Bonham the interventional pulmonary (IP) program (Kyle Imre Noth, MD - Co-directors) remains the top • Babak Mokhlesi, MD — Appointed as Respiratory Neurobiology Assembly Dr. Jessica Cooksey Hogarth, MD & Septimiu Murgu, MD - Co-direc- referral center for patients with interstitial lung the President-Elect for the Society of • Demonstrated that elevated levels of HLA-G are a Dr. Pamela McShane tors) one of the top three centers for bronchial disease in Chicago area. The chronic obstructive Anesthesia and Sleep Medicine. • Steven White, MD — Appointed to be member marker for a low-inflammatory endotype in asthma. thermoplasty, navigational bronchoscopy and pulmonary disease (COPD) program (Steven of ATS Publications Policy Committee and as (White, Naureckas, Hogarth, Solway, Sperling, et EBUS in the U.S., was enhanced in FY 17 with White, MD - Director) successfully reduced early • Septimiu Murgu, MD — Received the Clinician the Associate Vice Chair for Appointments and al., Journal of Allergy & Clinical Immunology, 2017) the recruitment of Dr. Frye and the expansion readmissions from 22% in 2012 to about 12% Educator Award from the American College Promotions for the Department of Medicine of the lung cancer screening and lung nodule in 2017. The pulmonary hypertension program of Chest Physicians and named as the Vice • Discovered that HIF regulates cellular metabolism in aortic endothelial cells evaluation clinics. The Section’s interstitial lung (Remzi Bag, MD - Director) maintained its volume Chair of Education Committee for CHEST. (Wu, Fang, Mutlu, et al., ELife 2017)

40 Department of Medicine 2017 Annual Report 41 Professors Assistant Professors Marcus Clark, MD (Chief) Anisha Dua, MD Maria-Luisa Alegre, MD, PhD Reem Jan, MD Michael Becker, MD+ Kichul Ko, MD James Curran, MD Vladimir Liarski, MD Leif Sorensen, MD, PhD+ Kimberly Trotter, MD Patrick Wilson, PhD Clinical Associate: Associate Professors Aimee Mayuga, MD Fotini Gounari, PhD Malay Mandal, PhD* Section Administrator Ann Leu

Dr. Marcus Clark +Emeritus *Research Appointee Track Faculty

Highlights, Accomplishments, section of and Discoveries:

Drs. Gounari, Ozcan & Liarski • Marisa Alegre, MD, PhD — at the 2017 Research Day Appointed as Co-Director of the Medicine rheumatology Keynote Presentation Microbiome Program

reputation for excellence in the treatment of During the past year, Section of rheumatic diseases. New clinical initiatives Rheumatology investigators: Autoimmunity has been a longstanding strength of the Section in FY 17 include a Vasculitis Center (Anisha Dua, MD - Director), a longitudinal study of • Provided new insights into the molecular of Rheumatology. Under the leadership of Marcus Clark, MD, lupus patients with nephritis (Kichul Ko, MD understanding of serological immunity - Director) and new a clinical fellowship in to influenza in young adults before and the Section continued its tradition of clinical excellence, innova- checkpoint blockade-induced autoimmunity. after administration (Wilson, et al., Nature Through the efforts of Drs. James Curran and Medicine, 2016) tive research and outstanding training focused on the pathogen- Reem Jan, the Inflammatory Arthritis Clinic has grown and has gained prominence in the • Described the impact of environmental esis of autoimmune diseases. In the past year, Section faculty community and now includes joint ultrasound. factors on immune function and on The Gout Clinic (Michael Becker, MD - Di- alloimmune function, as well as on transplant contributed to major advancements in the field of immunology rector) continues to be nationally prominent. fate (Alegre, et al., Journal of Clinical Investigation, 2016) that have the potential to translate into cutting edge treatments With research funding of nearly $6.0M, the Section’s robust investigative programs • Demonstrated that Bcl-2 is an attractive for those suffering from autoimmune and metabolic diseases. focus on innate and adaptive immunity with therapeutic target in patients with lupus a special emphasis on T and B cells which nephritis who manifest tubulointerstitial In FY 17 the Section of Rheumatology wel- are responsible for autoimmunity. In FY 17 inflammation (Ko, Liarski, Clark, et al., Dr. Vladimir Liarski comed Vladimir Liarski, MD, to the faculty. Dr. Section investigators were successful in Arthritis and Rheumatology, 2016) Liarski, assistant professor of medicine, is a obtaining additional federal NIH funding. Dr. Dr. Marisa Alegre graduate of the Section’s fellowship program Clark was awarded an NIH R21 to test a novel • Defined a new treatment option for gout and recently served as a Coggeshall Fellow. Dr. model of epigenetic regulation controlling Dr. Fotini Gounari, PhD received an award from On the educational front, the Section is very active patients (Becker, et al., Arthritis and Liarski’s research is focused on the study of the differentiation and selection of B cell devel- the American Association of Immunologists in multiple training and teaching venues. Within Rheumatology, 2017) role, cellular make-up, and processes that lead opmental states. Patrick Wilson, PhD was to study the properties of pathogenic RORyt/ the rheumatology fellowship program, the Section to inflammation. He is currently investigating awarded a NIH subcontract in collaboration Foxp3 double positive regulatory T cells in matched top three candidates from a record num- • Provided evidence that CTLA4-Ig in the importance of in situ immune responses in with the University of Pennsylvania to study colon cancer. Section faculty continued to ber of applications. The Section has also added combination with FTY720 promotes lupus renal interstitial inflammation and polymy- the impact of prior influenza exposures on an- be extremely productive, publishing results of new clinical rotations for the fellows in musculo- allograft survival in sensitized recipients ositis as part of his NIH K08 funded project. tibody repertoires to new viral strains. Marisa their work in high impact journals such as Cell, skeletal ultrasound. Finally, one fellow, Pankti Reid, (Alegre, et al., Journal of Clinical Alegre, MD, PhD, was awarded funding from Science, Nature Immunology, Immunity, Journal MD, has begun a clinical pharmacology fellow- Investigation Insights ,2017) The Section maintains outstanding disease the American Heart Association to study the of Clinical Investigation, Science Immunol- ship to develop expertise and study autoimmune focused clinical programs that drive its role of microbiota in allograft rejection and ogy and Science Translational Medicine. complications of checkpoint blockade in cancer.

42 Department of Medicine 2017 Annual Report 43 residents & fellows

INTERNAL MEDICINE RESIDENTS

2017 Chief Residents Second Year Residents Preliminary Second Year Residents PGY LEVEL MEDICAL SCHOOL ATTENDED PGY LEVEL MEDICAL SCHOOL ATTENDED PGY LEVEL MEDICAL SCHOOL ATTENDED PGY LEVEL MEDICAL SCHOOL ATTENDED Nikhil Bassi Northwestern University Sarah Feenstra II University of Chicago Edward Chen I University of Alabama Stephanie Kazantsev III University of Chicago Yasmin Karimi University of Pennsylvania Christopher Fernandes II University of Illinois Nicholas Feinberg I Columbia University Kathleen Kelley III Indiana University Cathryn Lee Emory University Felipe Fernandez del Castillo II University of Massachusetts Sarah Jarjour I University of Illinois Larry Napolitano III Case Western Reserve University Aaron Tannenbaum Temple University Christopher Frohne II University of Virginia Shruti Mishra I Washington University Amulya Gampa II University of Illinois Kevin Rogacki I Case Western Reserve University Raffi Hagopian II Ohio State University Jordan Standlee I Washington University First Year Residents 2018 Chief Residents Michael Hawking II University of Michigan Sean Wu I Case Western Reserve University Clifford Hsieh II University of Chicago Amrish Deshmukh Case Western Reserve University Jennifer Houpy II University of Chicago Emily Lund II Columbia University Abdulrahman Dia University of Illinois Anupama Joseph II Ohio State University Jared Wishik II University of Florida Michelle Fletcher University of Chicago Joshua Katz II Loyola University Physician Scientist Development Program Erica MacKenzie University of Chicago Kendall Kling II Loyola University Ariel Halper-Stromberg I Cornell University Grace Koo II University of Maryland Benjamin McDonald I University of Chicago EMERGENCY MEDICINE RESIDENTS Shawn Kothari II University of Pennsylvania Matthew Odenwald I University of Chicago Third Year Residents Ernesto Llano II University of Texas Southwestern Athalia Pyzer I University of Birmingham Third Year Residents Maria Bacalao III University of Texas Southwestern Alexandru Marginean II Rosalind Franklin University Sherin Rouhani II University of Virginia Sina Akhavan III University of California San Francisco Mark Belkin III Rush Medical College Daniel Meza II University of Illinois Obada Shamaa II Ohio State University Dillon Barron III University of North Carolina Margaret Boyle III Saint Louis University Elizabeth Munroe II University of Chicago Lauren Cooper III Meharry Medical College Samantha Catlett III Georgetown University Justin Porter II New York University Michael Ernst III Michigan State University Kira Charney III Michigan State University Elzbieta Stob II Creighton University MEDICINE-PEDIATRICS PROGRAM Steven Flynn III University of Washington Noa Cleveland III University of Illinois Julia Sun II Duke University Racheal Gilmer III University of Colorado Michael Cui III University of Chicago Eric Swei II Ohio State University Fourth Year Residents Omobolawa Kukoyi III Duke University Andre Davies III University of Chicago Natalie Tapaskar II Case Western Reserve University Jessica Gold IV Thomas Jefferson University Albert Leung III Harvard University Lauren Feld III Mount Sinai Adam Vohra II University of Chicago Katie Good IV Virginia Commonwealth University Andrew Marshall III Meharry Medical College Sarah Gray III University of Michigan Thomas Wagner II Medical College of Wisconsin Ellora Karmarkar IV University of California Los Angeles Jacob Moore III University of Illinois at Chicago Greg Haman III Harvard University Amy Wang IV University of Texas Houston Natalie Neumann III Harvard University Rebecca Harris III University of Chicago Archana Shah III Texas Tech University Blake Jones III Loyola University First Year Residents Brian Sprouse III University of California Irvine Albert Lee III University of California San Francisco Murtaza Bharmal I University of Vermont Third Year Residents Shameeke Taylor III University of Pittsburgh Linda Lee III Rush Medical College Kent Brummel I Northwestern University Zainab Abdul-Rahim III University of Massachusetts Joshua Wunder III Case Western Reserve University Zachary Lonjers III Loyola University Jennifer Cooperrider I Ohio State University Rebecca Chohlas-Wood III University of Washington Richard Zhang III University of Pittsburgh Marie McKinnon III University of Colorado Bonnie Diep I University of Southern California Thomas Couri III University of Chicago Priya Mehta III Ohio State University Elizabeth Donnelly I University of Chicago Robert Sanchez III University of Chicago Charles Muller III University of Chicago Donald Goens I University of California San Francisco Second Year Residents Julie Neborak III University of Minnesota Gregory Ingolia I University of Colorado Zakaria Abdulnabi II Case Western Reserve University Jerry Nnanabu III Brown University Anthony Kanelidis I University of Miami Second Year Residents Patrick Ardron-Hudson II Oregon Health & Science University Parita Patel III Case Western Reserve University Shivani Khanna I Boston University Erin Hickey II University of Colorado Maureen Canellas II University of Colorado Steven Pearson III University of Illinois Neal Klauer I University of Minnesota Stephanie Kelly II McGill University Mark Chottiner II University of Maryland Gina Piscitello III University of Minnesota Brian Labadie I University of California Irvine Jori Sheade II Rush Medical College Dustin Harris II University of California Los Angeles Caitlyn Plonka III University of Pittsburgh Jonathan Lattell I Loyola University Daniel Teixeira da Silva II Boston University Michelle Ho II University of Maryland Natalie Reizine III Loyola University Betty Li I University of Illinois Andrew Hogan II University of Texas Southwestern Trisha Saha III Duke University Austin Lin I University of Michigan Eric Keast II University of Michigan Claire Shappell III University of Chicago Maria Maldonado I Baylor College of Medicine First Year Residents Jason Kopec II University of Rochester Ethan Silverman III Wayne State University Michael Maranzano I Duke University Alanna Burnett I University of Illinois Hani Kuttab II Loyola University Danielle Stahlbaum III Case Western Reserve University Steven Mazzone I Rush Medical College Nathan Georgette I Harvard University Zayir Malik II Emory University David Tehrani III University of California Irvine Christopher Miller I University of Illinois Sanjay Jumani I Rutgers The State University of New Jersey Abdullah Pratt II University of Chicago Allison Thoburn III University of Illinois Rebeca Ortiz Worthington I University of Chicago Bennett Waxse I University of Texas Southwestern Kevin Quirke II Loyola University Eisha Wali III Case Western Reserve University Charles Oshinsky I New York University Charlotte Roy II Cornell University Hannah Wenger III University of Chicago Raghavendra Paknikar I University of Michigan Brian Strickland II University of Southern California Kathleen Pollard I George Washington University DERMATOLOGY RESIDENTS Garth Walker II University of Illinois at Chicago Eleanor Reimer I University of Michigan Second Year Residents Hannah Roth I University of Chicago Third Year Residents Nina Arhin II Meharry Medical College Brooke Scheidemantle I Thomas Jefferson University Laura Buford IV University of Oklahoma Rene Bermea, Jr II University of Chicago Anthony Serritella I Johns Hopkins University Jingyun (Juliana) Gao IV Duke University Brittany Bindon II Loyola University Wenfei Wang I University of Toledo Ashley Jenkins IV University of Missouri Keely Browning II Medical College of Wisconsin Hannah Wey I Rutgers The State University of New Jersey Rebecca Kaiser IV University of Chicago Kirk Cahill II University of Chicago William Wilson I Indiana University Mike Cheng II Case Western Reserve University Thomas Yates I Wake Forest University Noura Choudhury II University of Chicago Anthony de la Pena II University of Illinois

44 Department of Medicine 2017 Annual Report 45 residents & fellows

EMERGENCY MEDICINE RESIDENTS

First Year Residents Clinical Cardiac Electrophysiology Gastroenterology, Hepatology and Nutrition (continued) Nephrology PGY LEVEL MEDICAL SCHOOL ATTENDED PGY LEVEL MEDICAL SCHOOL RESIDENCY PGY LEVEL MEDICAL SCHOOL RESIDENCY PGY LEVEL MEDICAL SCHOOL RESIDENCY Leslie Anderson I University of Rochester Christopher Jones VII East Carolina University Marshall University Matthew Stier V Purdue University University of Chicago Ziad Al Khouri V University of Damascus Presence Health Brian Bush I University of Pittsburgh Yunwei Wang V Shanxi Medical University, China University of Nevada St. Joseph, Chicago Adriana Coleska I University of Michigan Thomas Cotter IV NUI Galway School of Medicine, Mayo Clinic Rochester Sangeet Dhillon-Jhattu V Saba University Advocate Lutheran General Emily DeDonato I Ohio State University Advanced Heart Failure Ireland Hospital, Park Ridge, IL Annette Dekker I Northwestern University Ben Chung VII Jefferson Medical School University of Chicago Sujaata Dwadasi IV Indiana University Emory University Margaret Kochanek V Chicago Medical School University of Illinois, Amelia Derstine I University of Michigan Ann Nguyen VII University of Texas Houston University of Chicago Nina Gupta IV University of Chicago University of Chicago Advocate Christ Medical Christopher Harris I University of Virginia Center Matthew Heuton I Harvard University Fuoad Kutuby V Jordan University of University of Illinois, Courtney Hutchins I Rush Medical College Cardiac Imaging Geriatrics and Palliative Medicine Science and Technology Advocate Christ Neha Goyal VII Maulana Azad Medical School Marshall University Michael Huber (Palliative) VI University of Chicago University of Chicago Medical Center Akhil Narang VII University of Illinois at Chicago University of Chicago Emily Escue (Palliative) V University of Tennessee University of Oklahoma Saurabh Chawla IV Medical College of John H. Stroger Jr. First Year Residents (continued) Vanessa Alonso (Geriatrics) IV Loyola University University of Chicago Thiruvananthapuram Hospital of Cook County Leigh Jackson I Meharry Medical College Adeela Cheema (Geriatrics) IV Allama Iqbal Medical College, Jamaica Hospital, Jeongwon Choi IV Catholic University of Korea Englewood Hospital Brendan McEvoy I University of Michigan Dermatology Pakistan New York & Medical Center Thomas O’Brien I Rutgers University Lohini Sundharkrishnan V Sree Balaji Medical College and Orlando Health Chandni Patel (Geriatrics) IV Case Western Reserve University University of Chicago Sai Prasad Gadapa IV Kakatiya Medical College,- India St. Francis Medical Center Kristina Pfeiffer I New York University Hospital of Chennai, India Victoria Vo IV University of Arizona University of Saaduddin Siddiqui I University of Chicago South Carolina Joseph Tarran I University of Chicago Hematology/Oncology Eric Wang I Georgetown University Endocrinology, Diabetes and Metabolism Arpita Desai VI Kempegowda Institute of University of Buffalo William Weber I Northwestern University Adult Medical Science Pulmonary/Critical Care Sonaina Imtiaz IV Rawalpindi Medical College, North Shore Medical Anu Neerukona V Kamineri Institute State University of Krysta Wolfe VII Georgetown University University of Chicago Pakistan Center, Salem, MA New York Karen Dugan VI Ohio State University University of Chicago FELLOWS Sikarin Upala IV Siriraj Hospital Faculty Bassett Medical Center Christine Bestvina V University of Pennsylvania Duke University Heng Duong VI Case Western Reserve University University of California,San of Medicine, Thailand Michael Drazer V University of Chicago University of Chicago Francisco Cardiology Cardiovascular Diseases Isabel Casimiro IV University of Washington University of Chicago James Godfrey V Ohio State University Ohio State University William Parker VI University of Chicago University of Chicago PGY LEVEL MEDICAL SCHOOL RESIDENCY Laura Dickens V Emory University University of Chicago Andrew Hantel V Loyola University University of Chicago Juan Rojas VI University of Illinois,Chicago University of Chicago Bhavna Balaney VI University of Illinois University of Pittsburgh Mizuho Mimoto VI Oregon Health & Science University University of Chicago Abiola Falilat Ibraheem V Obafemi Awolowo College Morehouse School Nathan Schoettler VI University of Chicago University of Chicago Rohan Kalthiya VI University of Kentucky Johns Hopkins of Medicine David Wu VI University of California, Los Angeles University of Chicago University Michael Jelinek V Rush Medical College University of Chicago Sivasubramanium V University of Texas, Galveston Baylor University Kebed Kalie VI University of Minnesota Mayo Clinic Pediatrics Kristen Tobin Vealey V Penn State University University of Chicago (Siva) Bhavani Luke Laffin VI Vanderbilt University University of Chicago Michelle Lemelman VI University of Miami University of Chicago Jennifer Veneris V University of Chicago University of Chicago James Katsis V St. George’s University Georgetown University Narang Nikhil VI University of Illinois University of Chicago Susan Tucker VI Rosalind N Franklin University Northwestern University Allison West V New York University University of Chicago Lucas Kimmig V University of Freiburg University of Pennsylvania Jeremy Stone VI University of Nebraska University of Nebraska Harini Kolluri V Andhra Medical College, India John Stroger Hospital Kristen Whitaker V Drexel University George Washington Julie Lin V University of Texas, Southwestern University of Texas, Lane Benes V University of Wisconsin University of Chicago Mary McCauley IV University of Illinois Lutheran General Hospital Southwestern Tharian Cherian V University of Chicago Stanford University Hospital Joseph Wynne V New York University University of Chicago Xuan (Susan) Han IV University of Chicago University of Chicago Heddy Luise Holzhauser V International Program Albert Einstein College Marlon Brathwaite IV Howard University The Steven and Benjamin Derman IV Northwestern University Rush University Cathryn Lee IV Emory University University of Chicago of Medicine Alexandra Cohen’s Brian Heiss IV University of Maryland University of Pittsburgh William Dwight Miller IV University of Virginia University of California, Paul Larsen V Tulane University University of California Medical Center Michael Leukam IV Loyola University University of Chicago Los Angeles Andrew Putnam V Loyola University University of Michigan Marquita Nelson IV Emory University Emory University Joseph Venturini V Loyola University University of Chicago Ofaf Osman IV Weill Cornell Medical Johns Hopkins Sleep Medicine Rajeev Anchan IV University of Nebraska University of Nebraska Gastroenterology, Hepatology and Nutrition University Farbod Ghhods VII Shahid Beheshti University Loyola University Emeka Anyanwu IV Case Western Reserve University University of Chicago Roni Weisshof VIII Technion, Hifa, Israel Rambam Medical Daniel Olson IV Rush Medical College Northwestern University of Medical Sciences Ilya Karagodin IV Northwestern University Medical College of Center Sheila Padma Rajogopal IV Columbia University University of Pittsburgh Amanpreet Kaur VII Northeast Ohio Medical University Brown University Wisconsin Steven Shamah VIII Tel Aviv University, Isreal Maimonides Medical Jonathan Trujillo IV University of Iowa University of Chicago Carmela Kiraly IV Vanderbilt University University of Chicago Isla McClelland IV Georgetown University Medstar Georgetown Center University Jacob Ollech VII Semmelweis University Hadassah University Andrew Oehler IV Indiana University Oregon Health and Medical Center Hospital Medicine /Hospitalist Scholars Interventional Pulmonology Science University Adam Mikolajczyk VII University of Chicago University of Chicago Ali Thaver IV Johns Hopkins University Johns Hopkins Jonathan Kurman VII Albany Medical College Medical College of Dong Bo Yu IV University of Texas Southwestern University of Chicago Neha Nigam VI Georgetown University Georgetown University University Wisconsin Anna Lipowska VI Emory University Northwestern University Mark Anthony Sofia VI University of Chicago University of Chicago Interventional Cardiology Adjoa Anyane-Yeboa VI University of Cincinnati University of Illinois, Infectious Diseases & Global Health Rheumatology Taishi Hirai Nagoya University School of Medicine Loyola University Chicago Leona Ebara VI Kobe University University of Pankti Reid V Ohio State University University of Cincinnati Medical Center George Ou VI Penn State University University of British New Mexico Iazsmin Ventura V Universidade de Brasilia Icahn School of Medicine Jonathan Rosenberg VII Northwestern University University of Chicago Columbia Margaret Newman V University of Illinois at Chicago University of Illinois Veena Patel V American University of UTHealth McGovern Thomas Lu V University of Cincinnati University of Chicago at Chicago Antigua College of Medicine Medical School Bianca Chang V Cornell University Cedars-Sinai Medical Amutha Rajagopal V University of California, San Diego Scripps Green Hospital Josna Haritha IV University of Alabama Virginia Commonwealth Center Cassandra Betts IV University of Michigan Oregon Health & University Sciences University Matthew Enriquez IV Thomas Jefferson University Thomas Jefferson University 46 Department of Medicine 2017 Annual Report 47 residents & fellows

GRADUATES FY 17

Internal Medicine Dermatology Heart and Vascular Infectious Diseases and Global Health NAME POSITION INSITUTION NAME POSITION INSITUTION NAME POSITION INSITUTION NAME POSITION INSITUTION Vanessa Alonso Geriatrics Fellow University of Chicago Ashley Feneran Private Practice Chicago, Illinois Sara Kalantari Assistant Professor of Medicine University of Chicago Mary Ellen Acree Attending Physician Northshore University Emeka Anyanwu Cardiology Fellow University of Chicago Heather Peck Anatomic and Clinical Pathologist Clinical Laboratory of the Ajay Patel Private Practice Bakersfield Heart Hospital Health System Joshua Bakke Dermatology Resident University of Tennessee Black Hills Andrew Beaser Assistant Professor of Medicine University of Chicago Daniela Pellegrini Attending Physician Mercy Health Partners, Nikhil Bassi Cardiology Fellow University of California, Haider Bangash Private Practice Elmhurst Dermatology Kelvin Chua Hong Kong Muskegon, Michigan Los Angeles Olga Radkevich-Brown Clinical Associate/Private Practice University of Chicago/ Ankit Bhatia Cardiology Fellow Washington University Southwest Daniel Bradley Radiology Resident University of California, Dermatology, Orland Park Endocrinology, Diabetes & Metabolism Nephrology Los Angeles Carly Roman Private Practice Modern Dermatology, Rajesh Jain Assistant Professor of Medicine Temple University Manpreet Samra Assistant Professor, University of Illinois, Chicago Abdallah Bukari Hospitalist University of Chicago Seattle, Washington Katie O’Sullivan Assistant Professor of Medicine University of Chicago Transplant Nephrology NorthShore Magdalena Dumin Pediatric Endocrinologist Academic Endocrinology- Omar Al Dhaybi Hypertension Fellow University of Chicago Anisha Chandiramani Informatics Fellow Duke University Wheaton, IL Vamshi Bende Hospitalist Franciscan Health Nimit Desai Hospitalist University of Chicago Emergency Medicine Munster, Indiana NorthShore Elyssa Berg Attending Physician Locum Tenens Amrish Deshmukh Chief Resident University of Chicago Andrew Bokarius Attending Physician Mercy Health System; Gastroenterology, Hepatology & Nutrition Abdulrahman Dia Chief Resident University of Chicago Lake Geneva, WI Emmauel Coronel Advanced Endoscopy Fellow MD Anderson Pulmonary/Critical Care Danielle Farrington Chief Resident MacNeal Hospital Colton Clay Attending Physician Northwest Community Bilal Gondal Staff Physician University of Illinois, Ayodeji Adegunsoye Coggeshall Fellow University of Chicago Michelle Fletcher Chief Resident University of Chicago Hospital, Urbana Leah Witt Geriatrics Fellow University of California, Nathan Frogge Cardiology Fellow Washington University Arlington Heights, IL Vijaya Rao Assistant Professor of Medicine University of Chicago San Francisco Shewit Giovanni Pulmonary and Critical Care Fellow University of Washington Amy Ho Associate Medical Director John Peter Smith Hospital Arsalan Khan Hospitalist Advocate Christ Hosptial Xiaoxiao Guo Anesthesiology Resident Emory University and Integrative Emergency Sudarshan Paramsothy Advanced IBD Fellow Mount Sinai, NY Nina Gupta Gastroenterology Fellow University of Chicago Services; Dallas, TX Keith Naylor Clinical Lecturer University of Michigan Sleep Medicine Susan Han Pulmonary and Critical Care Fellow University of Chicago Joffre Johnson Attending Physician St. Joseph Mercy Hospital; Jennifer Butler Attending Physician Piedmont Hospital, GA Yasmin Karimi Hematology/Oncology Fellow Stanford University Ann Arbor, MI Julio Noda Milla Attending Physician Salem Health, Salem, OR Katherine Khatibi Anesthesiology Resident Johns Hopkins University Carrie Jurkiewicz Wilderness Medicine Fellow Stanford University General Internal Medicine Adam Rappoport Instructor Nemours Children’s Carmela Kiraly Sleep Medicine Fellow University of Chicago Paul Kukulski Medical Education Fellow University of Chicago Elizabeth Tung Pathway Instructor University of Chicago Specialty Care David Kopelman Cardiovascular Hospitalist Intermountain Medical Ernest Nwachukwu Attending Physician Houston Methodist West Ashley Haddad Internal Medicine Physician Oak Street Health Center Hospital; Houston, TX Cathryn Lee Pulmonary and Critical Care Fellow University of Chicago Jen Nykiel Attending Physician Fairview Hospital; Interventional Pulmonology Michael Leukam Hematology/Oncology Fellow University of Chicago Great Barrington, MA Geriatrics and Palliative Medicine Sean Stoy Attending Physician Undecided Katherine Ligtenberg Dermatology Resident Yale University Alejandro Palma Assistant Professor of Medicine University of Chicago Pringl Miller (Palliative) Palliative Medicine Physician Rush University Medical Nayna Lodhia Gastroenterology Fellow Brigham and Women’s Nishma Sachedina Attending Physician Holy Cross Hospital; Center/JourneyCare Hospice Erica MacKenzie Chief Resident University of Chicago Ft. Lauderdale, FL Janet Starck (Palliative) Director, Palliative Medicine Inpatient Unit VITAS Hospice and Rheumatology Mary Masters Infectious Diseases Fellow Northwestern University Yong Suh Clinical Partner CEP America; Palliative Medicine Heena A. Birbal Jain Attending Physician University of Illinois Chandni Patel Geriatrics Fellow University of Chicago Emeryville, CA Emily Escue (Geriatrics) Hospice & Palliative Medicine Fellow University of Chicago Ahmad Salah Attending Rheumatologist Franciscan Alliance/Health Krishna Patel Research Year / Dermatology Resident Northwestern University/ Eric Toone Attending Physician Carle Hospital; Michelle Martinchek (Geriatrics) Assistant Professor of Medicine University of Chicago University of Illinois Champagne, IL Juan Reyes Genere Gastroenterology Fellow Mayo Clinic Omar Usman Medical Informatics Fellow Stanford University Erin Rocci Dermatology Resident Mayo Clinic Kenneth Young Simulation Fellow NorthShore University Hematology/Oncology Sandra Shi Geriatrics Fellow Beth Israel Deaconess HealthSystem Jamie Brewer Pharmacology Fellow University of Chicago Medical Center Kevin Wood Assistant Professor of Medicine University of California, Aadhavi Sridharan Cardiology Fellow Tufts University San Diego Aaron Tannenbaum Pulmonary and Critical Care Fellow University of Pennsylvania Cardiology Poornima Chennamaneni Academic Lead of Northshore Justin Tomal Gastroenterology Fellow Vanderbilt University Isida Byku Interventional Fellow Emory University Breast Medical Oncology Dovie Watson Infectious Diseases Fellow University of Pennsylvania Ben (Bow Young) Chung Advanced Heart Failure and University of Chicago Steven Maron Coggeshall Fellow University of Chicago Benjamin Weber Cardiology Fellow Loyola University Transplant Cardiology Fellow Michael Tallarico Attending medical Northwest Oncology, P.C Mia Weiss Hematology/Oncology Fellow Rush University Akhil Narang Cardiac Imaging Fellow University of Chicago oncologist/hematologist Dong Bo Yu Cardiology Fellow University of Chicago Annie Nguyen Advanced Heart Failure University of Chicago Sope Olugbile Assistant Professor of Medicine The Ohio State University Dawen Zhang Rheumatology Fellow University of California, and Transplant Cardiology Fellow Randy Sweis Pathway Instructor University of Chicago Los Angeles Adam Oesterle Advanced Electrophysiology Fellow University of California, Linda Zhu Hospitalist University of Chicago San Francisco NorthShore Jonathan Rosenberg Interventional Fellow University of Chicago Hospital Medicine /Hospitalist Scholars Amita Singh Assistant Professor of Medicine University of Wisconsin Jonathan Erlich Gastroenterology Fellow Beth Israel Deaconess Noreen Nazir Assistant Professor of Medicine University of Illinois, Medical Center Medicine-Pediatrics Chicago Michael Huber Geriatrics and Palliative Care Fellow University of Chicago Sofija Degesys Allergy & Immunology Fellow University of Michigan Diego Medvedofsky Cardiovascular Investigator, Faculty Core Lab of the MedStar Jonathon Lio Assistant Professor of Medicine University of Chicago Vincent DiMaggio Chief Resident (Pediatrics) University of Chicago Health Research Institute Marc Robinson Assistant Professor of Medicine Baylor College of Medicine Natalia Genere Endocrinology Fellow Mayo Clinic Jonathan Grinstein Advanced Heart Failure Physician Medstart Ashley Thomas Palliative Care Fellow Vanderbilt University

48 Department of Medicine 2017 Annual Report 49 select high impact publications Hemisphere Revealed by the African Diaspora Genome. Nature 8. Park JW, Liu MC, Yee D, Yau C, van ‘t Veer LJ, Symmans WF, Paoloni M, 13. Skelly CL, Cifu AS. Screening, Evaluation, and Treatment of Peripheral Communications 7:12522,2016 Perlmutter J, Hylton NM, Hogarth M, DeMichele A, Buxton MB, Chien AJ, Department of Medicine faculty are extremely Arterial Disease. Journal of the American Medical Association 316(14): 2. Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey RC, Stock W, Mul- Wallace AM, Boughey JC, Haddad TC, Chui SY, Kemmer KA, Kaplan HG, 1486-148,2016 lighan CG. Genomic Analyses Identify Recurrent MEF2D Fusions in Acute Isaacs C, Nanda R, Tripathy D, Albain KS, Edmiston KK, Elias AD, Northfelt productive, publishing over 1400 original 14. Tao JX, Davis AM. Management of an Unprovoked First Seizure in Adults. Lymphoblastic Leukaemia. Nature Communications 7:13331,2016 DW, Pusztai L, Moulder SL, Lang JE, Viscusi RK, Euhus DM, Haley BB, Khan Journal of the American Medical Association 316(15):1590-1591,2016 3. Lawrenson K, Kar S, McCue K, Kuchenbaeker K, Michailidou K, QJ, Wood WC, Melisko M, Schwab R, Helsten T, Lyandres J, Davis SE, Hirst articles in a number of outstanding internal 15. Patel BK, Hall JB, Kress JP. Face Mask vs Helmet for Noninvasive Ventila- Tyrer J, Olopade OI, Gayther SA. Functional Mechanisms Underly- GL, Sanil A, Esserman LJ, Berry DA. Adaptive Randomization of Neratinib in tion-Reply. Journal of the American Medical Association 316(14):1492,2016 ing Pleiotropic Risk Alleles at the 19p13.1 Breast-Ovarian Cancer Early Breast Cancer. New England Journal of Medicine 375(1):11-22,2016 16. Cifu AS, Walker DD, Gluth MB. Guidelines for Tinnitus-Reply. Journal of the Susceptibility Locus. Nature Communications 7:12675,2016 9. Rugo HS, Olopade OI, DeMichele A, Yau C, van ‘t Veer LJ, Buxton MB, Ho- medicine and subspecialty journals. Below is a American Medical Association 316(11):1215,2016 garth M, Hylton NM, Paoloni M, Perlmutter J, Symmans WF, Yee D, Chien AJ, 17. Roman CJ, Cifu AS, Stein SL. Management of Acne Vulgaris. Journal of the Nature Genetics Wallace AM, Kaplan HG, Boughey JC, Haddad TC, Albain KS, Liu MC, Isaacs sampling of some recent high impact papers. American Medical Association 316(13):1402-140,2016 1. Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth C, Khan QJ, Lang JE, Viscusi RK, Pusztai L, Moulder SL, Chui SY, Kemmer KA, 18. Sanders GD, Neumann PJ, Basu A, Brock DW, Feeny D, Krahn M, Kuntz KM, KS, Whalen S, Sarkar AK, Albrecht E, Altmaier E, Amini M, Im HK, Hinds D, Elias AD, Edmiston KK, Euhus DM, Haley BB, Nanda R, Northfelt DW, Tripathy Meltzer DO; Owens DK, Prosser LA, Salomon JA, Sculpher MJ, Trikalinos TA, Murray A, Murabito JM, Stefansson K, Ong KK, Perry JRB. Genomic Analyses D, Wood WC, Ewing C, Schwab R, Lyandres J, Davis SE, Hirst GL, Sanil A, Annals of Internal Medicine Russell LB, Siegel JE, Ganiats TG. Recommendations for Conduct; Method- Identify Hundreds of Variants Associated with Age at Menarche and Support a Berry DA, Esserman LJ . Adaptive Randomization of Veliparib-Carboplatin Treat- ological Practices; and Reporting of Cost-effectiveness Analyses: Second Role for Puberty Timing in Cancer Risk. Nature Genetics, 49(6):834-841 ,2017 ment in Breast Cancer. New England Journal of Medicine 375(1):23-34,2016 1. Edelson DP; Churpek MM. Annals for Hospitalists Inpatient Notes - Predicting Panel on Cost-Effectiveness in Health and Medicine. Journal of the American 2. Phelan CM; Kuchenbaecker KB; Tyrer JP; Kar SP; Lawrenson K; Winham SJ, 10. Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford Codes-A Future With Fewer In-Hospital Cardiac Arrests. Annals Internal Medical Association 316(10):1093-10,2016 Olopade OI, Pharoah PD. Identification of 12 New Susceptibility Loci for JG, Marques dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Medicine 16;166(10),2017 19. McNulty M, Cifu AS, Pitrak D. HIV Screening. Journal of the American Different Histotypes of Epithelial Ovarian Cancer. Nature Genetics Gilbert JA, Holbreich M, Thorne PS, Martinez FD, von Mutius E, Vercelli D, Cell Medical Association 316(2):213-4,2016 49(5):680-691,2017 Ober C, Sperling AI. Innate Immunity and Asthma Risk in Amish and Hutterite 20. Dunlap B, Cifu AS. Clinical Management of Opioid Use Disorder. Journal of 3. Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Farm Children. New England Journal of Medicine 375(5):411-21,2016 1. Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, Bieseck- the American Medical Association 316(3):338-9,2016 Stock W, Mullighan CG. Deregulation of DUX4 and ERG in Acute Lym- er LG, Worthey E, Chisholm RL, Green ED, Jacob HJ, McLeod HL,Roden 21. Steiger N, Cifu AS. Primary Prevention of Stroke. Journal of the American phoblastic Leukemia. Nature Genetics 48(12):1481-1489 ,2016 Proceedings from the National Academy of Sciences USA D, Rodriguez LL, Williams MS, Cooper GM,Cox NJ, Herman GE, King- Medical Association 316(6):658-9,2016 1. Peng YJ; Zhang X; Gridina A; Chupikova I; McCormick DL; Thomas RJ; smore S, Lo C, Lutz C, MacRae CA, Nussbaum RL, Ordovas JM, Ramos 22. Chopra V, Edelson DP, Saint S. Mentorship Malpractice. Journal of the Nature Medicine Scammell TE; Kim G; Vasavda C; Nanduri J; Kumar GK; Semenza GL; EM, Robinson PN, Rubinstein WS, Seidman C, Stranger BE, Wang American Medical Association 315(14):1453-1454,2016 1. Lee J, Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, Snyder SH; Prabhakar NR .Complementary Roles of Gasotransmitters CO H, Westerfield M, Bult C. Bedside Back to Bench: Building Bridges be- Wilson PC, Kwong PD, Georgiou G. Molecular-Level Analysis of the and H2S in Sleep Apnea. Proceedings from the National Academy of tween Basic and Clinical Genomic Research. Cell 169(1):6-12 ,2017 Journal of Clinical Investigation Serum Antibody Repertoire in Young Adults Before and After Season- Sciences USA 114(6):1413-1418,2017 2. Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, 1. Riella LV, Bagley J, Iacomini J, Alegre ML. Impact of Environmental Factors al Influenza Vaccination. Nature Medicine 22(12):1456-1464,2016 2. Arina A, Idel C, Hyjek EM, Alegre ML, Wang Y, Bindokas VP, Firestone AJ, Young A, Lacap JA,Crocker L, Asthana S, Davis EM, Xu J, on Alloimmunity and Transplant Fate. Journal of Clinical Investigation Weichselbaum RR, Schreiber H. Tumor-associated Fibroblasts Predom- Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, 127(7):2482-2491,2017 New England Journal of Medicine inantly Come from Local and Not Circulating Precursors. Proceedings Evangelista M, Shannon K . KRAS Allelic Imbalance Enhances Fitness and 2. Gilles L, Arslan AD; Marinaccio C, Wen QJ, Arya P, McNulty M, Yang Q, Zhao 1. DeMartino ES, Dudzinski DM, Doyle CK, Sperry BP, Gregory SE, Siegler M, from the National Academy of Sciences USA 113(27):7551-6,2016 Modulates MAP Kinase Dependence in Cancer. Cell 168(5):817-829,2017 JC, Konstantinoff K, Lasho T, Pardanani A, Stein B, Plo I, Sundaravel S, Wick- Sulmasy DP, Mueller PS, Kramer DB. Who Decides When a Patient Can’t? 3. Spranger S, Luke JJ, Bao R, Zha Y, Hernandez KM, Li Y, Gajewski AP, Journal of the American Medical Association rema A, Migliaccio A, Gurbuxani S, Vainchenker W, Platanias LC, Tefferi A, Statutes on Alternate Decision Makers. New England Journal of Medicine Andrade J, Gajewski TF. Density of Immunogenic Antigens Does Not Explain Crispino JD. Downregulation of GATA1 Drives Impaired Hematopoiesis in Pri- 376(15):1478-1482,2017 the Presence or Absence of the T-cell-Inflamed Tumor Microenvironment in 1. Jain A, Cifu AS. Antithrombotic Therapy for Venous Thromboembolic Disease. mary Myelofibrosis. Journal of Clinical Investigation 127(4):1316-1320,2017 2. Hochhaus A, Larson RA, Guilhot F, Radich JP, Branford S, Hughes TP, Melanoma. Proceedings from the National Academy of Sciences USA Journal of the American Medical Association 317(19):2008-2009,2017 3. Lei YM, Chen L, Wang Y, Stefka AT, Molinero LL, Theriault B, Aquino-Michaels Baccarani M, Deininger MW, Cervantes F, Fujihara S, Ortmann CE, 113(48):E7759-E7768,2016 2. Kavitt RT, Cifu AS. Management of Helicobacter pylori Infection. Jour- K, Sivan AS, Nagler CR, Gajewski TF, Chong AS, Bartman C, Alegre ML. Menssen HD, Kantarjian H, O’Brien SG, Druker BJ. Long-Term Outcomes of 4. He W, Tan GS, Mullarkey CE, Lee AJ, Lam MM, Krammer F, Henry C, nal of the American Medical Association 317(15):1572-1573,2017 The Composition of the Microbiota Modulates Allograft Rejection. Journal of Imatinib Treatment for Chronic Myeloid Leukemia. New England Journal of Wilson PC, Ashkar AA, Palese P, Miller MS. Epitope Specificity Plays a Critical 3. Brito JP, Montori VM, Davis AM. Metabolic Surgery in the Treatment Algorithm Clinical Investigation 126(7):2736-44.2016 Medicine 37(10):917-927,2017 Role in Regulating Antibody-dependent Cell-mediated Cytotoxicity Against for Type 2 Diabetes: A Joint Statement by International Diabetes Organiza- 3. Welch JS, Petti AA, Miller CA, Fronick CC, O’Laughlin M, Fulton RS, Wilson Influenza A Virus. Proceedings from the National Academy of Sciences USA tions. Journal of the American Medical Association 317(6):635-636,2017 Lancet RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi 113(42):11931-11936,2016 4. Medalie L, Cifu AS. Management of Chronic Insomnia Disorder in Adults. 1. Ginsburg O, Badwe R, Boyle P, Derricks G, Dare A, Evans T, Eniu A, Jimenez J, A, Tomasson MH, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein KE, 5. Priyamvada L, Quicke KM, Hudson WH, Onlamoon N, Sewatanon J, Journal of the American Medical Association 317(7):762-763,2017 Kutluk T, Lopes G, Mohammed SI, Qiao YL, Rashid SF, Summers D, Sarfati D, Vij R, Oh ST, Abboud CN, Cashen AF, Schroeder MA, Jacoby MA, Heath Edupuganti S, Pattanapanyasat K, Chokephaibulkit K, Mulligan MJ, Wilson 5. Roman CJ, Cifu AS, Stein SL. Clinical Guidelines for Management of Acne Temmerman M, Trimble EL, Padela AI, Aggarwal A, Sullivan R. Changing SE, Luber K, Janke MR, Hantel A, Khan N, Sukhanova MJ, Knoebel RW, PC, Ahmed R, Suthar MS, Wrammert J. Human Antibody Responses After Vulgaris-Reply. Journal of the American Medical Association 317(2):213,2017 Global Policy to Deliver Safe, Equitable, and Affordable Care for Women’s Stock W, Graubert TA, Walter MJ, Westervelt P, Link DC, DiPersio JF, Ley Dengue Virus Infection are Highly Cross-reactive to Zika Virus. Proceedings 6. Howell MD, Davis AM. Management of Sepsis and Septic Shock. Journal of Cancers. Lancet 389(10071):871-880, 2017 TJ .TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic from the National Academy of Sciences USA 113(28):7852-7,2016 the American Medical Association 317(8):847-848,2017 Syndromes. New England Journal of Medicine 375(21):2023-2036,2016 7. Cohen RN, Davis AM. Management of Adult Patients with Thyroid Nodules Nature 4. Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Science and Differentiated Thyroid Cancer. Journal of the American Medical 1. Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Dolan ME, Harrington K, Kasper S, Vokes EE, Even C, Worden F, Saba NF, Iglesias 1. Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Association 317(4):434-435,2017 Murray SA. High-throughput Discovery of Novel Developmental Phenotypes. Docampo LC, Haddad R, Rordorf T, Kiyota N, Tahara M, Monga M, Lynch M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, 8. 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50 Department of Medicine 2017 Annual Report 51 committee highlights

Women’s Committee Women’s Committee The Department of Medicine’s Women’s Organizations and Professor of Organization residents from all of the medical schools in Chi- Committee serves as an important mechanism and Management in the Kellogg School of cago and three from the east coast attended the for networking, mentorship, professional Management at Northwestern University event. The forum was moderated by Milda Saun- development and advocacy for our female ders, MD with participation by Drs. Monica Peek, faculty. With leadership from Helen Te, MD, • Hosted Mark Linzer, MD, Division Director, Rochelle Naylor, Doriane Miller and Keme Carter the Committee is comprised of women from General Internal Medicine Clinics, Henne- from the Department. The Bowman Society also multiple sections within the Department, all of pin County Medical Center, as the Wom- hosted the first-ever “Black Men in Medicine” Fo- whom are amazing leaders, scientists, clinicians en’s Committee’s Grand Round Speaker rum, bringing faculty from various Chicago medi- and educators in their own right. On October for 2017, who spoke on “The Epidemic of cal institutions together with Pritzker medical stu- 1, 2017 Julie Oyler, MD, Associate Professor Physician Burnout: We Can Turn It Around” dents and residents in an open panel discussion. of Medicine, assumed the role as Chair of Seven panelists, including Medicine faculty Drs. Women’s Committee. Dr. Oyler succeeds Diversity Committee Keith Naylor and Edwin McDonald, were drawn Dr. Te who has led the Women’s Committee The Department of Medicine actively promotes from three different Chicago medical schools since 2014 and has accepted a position on the diversity, community-based research, and and together, represented decades of collective University of Chicago’s Women’s Leadership understanding (toward eliminating) health care experience in the fields of cardiology, gastroenter- Council. The Department is grateful for Dr. disparities. The goal of the Diversity Committee, ology, pediatrics, psychiatry, and ophthalmology. Te’s outstanding leadership of the Women’s led by Monica Vela, MD, is to build upon the long Committee over the past three years. tradition of excellence in the fields of clinical care, Other highlights from FY 17 include: research and education by working to improve The DOM Women’s Committee enjoyed diversity among all programs in the Department. • Doriane Miller, MD – Recipient of the several successes in FY 17: Department of Medicine’s Diversity Award • Published two issues of the “Women at the In addition, the Diversity Committee serves to Forefront” newsletter, highlighting the accom- focus and promote departmental activities that • Monica Vela, MD – Recipient of Please visit medicine.uchicago.edu for a full version Editorial direction by Annette Westerberg plishments of women faculty and trainees improve recruitment, retention, scholarship, the Distinguished Leader in Diversity of the 2017 Department of Medicine Annual Report Art Direction and Graphic Design leadership, and mentorship of minority medical and Inclusion (Senior) Award by the which includes a detailed list of sponsored research by Sean P. Hernandez at Graphic Arts ([email protected]) • Conducted a workshop, “Speak for Success,” students, house staff and faculty in an environ- Biological Sciences Division Photography by David Christopher, Jean Lachat, featuring Lori Klinka, a public speaking coach ment rich with cultural awareness, and sensitivity. Matthew Wood and UC Creative To that end, in FY 17, under the direction of Dr. • Sonia Kupfer, MD – Recipient of Special thanks to Marguerite Boone and • Conducted a workshop on “Leading High Vela, the Bowman Society hosted “Empowerment the Distinguished Leader in Diversity Samantha Delacruz for editorial assistance Impact Teams,” featuring Leigh Thompson, J. Stories” the Inaugural Black and Latina Women in and Inclusion (Junior) Award by the Jay Gerber Professor of Dispute Resolution & Medicine Forum. Over 60 medical students and Biological Sciences Division

52 Department of Medicine 2017 total sponsored SECTION OF COMPUTATIONAL BIOMEDICINE AND BIOMEDICAL DATA SCIENCE PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE research awards Grossman, Robert The Bionimbus Protected Data Cloud (Subcontract with LBR) $43,822 $25,417 Workshop on Translational Data Science $25,000 $0 Innovation through collaboration at the intersection of childhood development $565,613 $350,680 and cancer: a platform for the Gabriella Miller Kids First Pediatric Data Resource Center Melamed, Rachel Using Clinical Data to Identify FDA-Approved drugs for $116,142 $8,811 Cancer Prevention and Therapeutic Repurposing Rzhetsky, Andrey 2/2-Measuring Translational Dynamics and the Proteome to $380,000 $220,400 Identify Potential Brain Biomarkers for Psychiatric Disease Training in Emerging Multidisciplinary Approaches to Mental Health and Disease $263,466 $18,517

Total PHS Research $1,394,043 $623,825

STATE/ASSOCIATION/FOUNDATION GRANTS Grossman, Robert Cohen Veterans Bioscience Data Commons Grant Agreement (CVB) $805,727 $120,859

Total State/Association/Foundation Grants $805,727 $120,859

INDUSTRY GRANTS Grossman, Robert Abbvie Partnership (AbbVie) $89,286 $35,714

Total Industry Grants $89,286 $35,714

FY 17 Total Sponsored Research SECTION OF CARDIOLOGY Public Health Service $2,017,868 State/Association/Foundations $926,586 PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE Industry Grants $125,000 Alenghat, Francis Integrin-Triggered Signaling and $136,085 $10,887 TOTAL $3,069,454 Macrophage Mode Switching in Atherosclerosis Broman, Michael FOG-2 Upregulation Induces Atrial Fibrillation $119,395 $9,552 Liao, James Cardiovascular Sciences Training Grant $476,254 $35,667 Lipoproteins Effect on G Protein Function $250,000 $145,000 Ozcan, Cevher Mitochondrial Mechanisms and $151,800 $12,144 Novel Therapeutic Targets in Atrial Fibrillation Polonsky, Tamar Myocardial Ischemia & Transfusion (Subcontract with Rutgers) $81,391 $49,916

Total PHS Research $1,214,925 $263,166

STATE/ASSOCIATION/FOUNDATION GRANTS Blair, John Microvascular Dysfunction in Heart Failure $70,000 $7,000 with Preserved Ejection Fraction (American Heart Association) Polonsky, Tamar Aspirin Dosing: A Patient-Centric Trial Assessing Benefits $184,341 $36,868 and Long-term Effectiveness (PCORI/Chicago Community Trust) Tabit, Corey Molecular Mechanisms of Non-Surgical Bleeding in Human Patients $70,000 $7,000 (American Heart Association) Wu, Rongxue Functional characterization of ARNT/HIF1beta (American Heart Association) $70,000 $7,000

Total State/Association/Foundation Grants $394,341 $57,868

INDUSTRY GRANTS Ancsin, John Peptidomimetics with Companion Assay $64,267 $25,707 for the Treatment of Hypertriglyceridemia (CORVIDIA) Nayak, Hemal Clinical Cardiac Electrophysiology Fellowship Program (Medtronic) $30,000 $0 University of Chicago Clinical Cardiac Electrophysiology $25,000 $0 (CCEP) Fellowship Program (Boston Scientific) Spencer, Kirk Thomas Finding-based Clinical Context Delivery (Philips) $14,286 $5,714

Total Clinical Trials Earnings $1,468,373 $367,093 Total Industry Grants $1,601,926 $398,514

Total Sponsored Research FY13 FY 14 FY 15 FY16 FY17 Public Health Service $5,049,581 $3,816,494 $1,963,339 $1,807,597 $1,478,091 State/Association/Foundations $564,683 $429,876 $472,312 $391,786 $452,209 Industry Grants $1,614,635 $885,107 $1,356,465 $1,668,923 $2,000,440 TOTAL $7,228,899 $5,131,477 $3,792,116 $3,868,306 $3,930,740

54 Department of Medicine 2017 Annual Report 55 2017 total sponsored research awards

SECTION OF EMERGENCY MEDICINE PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE Beiser, David Mechanical Circulatory Support: Measures of Adjustment and Quality of Life $24,615 $14,277 Prabhakar, Nanduri Integrative Consequences of Hypoxia $1,440,360 $607,332 Therapeutic Targeting of Carotid Body Chemoreflex for Sleep Disordered Breathing $1,392,573 $299,698 Sharp, Willard Pharmacological Induced Torpor/Hypothermia as a $500,000 $290,000 Novel Therapy for Improving Post Cardiac Arrest Resuscitation Outcomes

Total PHS Research $3,357,548 $1,211,307

STATE/ASSOCIATION/FOUNDATION GRANTS Hogan, Teresita Developing a National Collaborative to Improve Emergency Department Care $43,200 $4,320 of Older Adults (Hartford/Geriatrics) Jurkiewicz, Carrie Altitude Sickness Prevention with Ibuprofen Relative $5,000 $0 to Acetazolamide Trial for Efficacy (WMS) Padela, Aasim Developing a Tailored Mammography Intervention $134,954 $10,796 for American Muslims (American Cancer Society) Domesticating Genomics in the Gulf Region: $25,000 $5,000 The Missing Islamic Bioethical Discourse (QNRF/HBKU) Beyond Preservation: The Higher Objectives of Islamic Law $25,000 $0 and the Enhancement of Life (John Templeton Foundation)

Total State/Association/Foundation Grants $233,154 $20,116

Total Sponsored Research FY 13 FY 14 FY 15 FY 16 FY17 Public Health Service $2,848,670 $2,191,789 $3,797,030 $3,696,644 $4,568,855 State/Association/Foundations $131,092 $285,934 $234,682 $261,822 $253,270 Industry Grants $40,000 $182,173 $142,173 $0 $0 TOTAL $3,019,762 $2,659,896 $4,173,885 $3,958,466 $4,822,125

SECTION OF DERMATOLOGY PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE He, Yu-Ying Autophagy and GG-NER in UVB-Induced Skin Cancer $225,000 $130,500 Oxidative stress, Cr(VI) Carcinogenesis, and Prevention $50,000 $29,000 (Subcontract with the University of Kentucky) Lang, Deborah PAX3 pathways in melanoma $228,750 $127,580

Total PHS Research $503,750 $287,080

STATE/ASSOCIATION/FOUNDATION GRANTS He, Yu-Ying Natural Remedy Oral Supplement (GHMST) $60,000 $24,000

Total State/Association/Foundation Grants $60,000 $24,000

Total Sponsored Research FY13 FY 14 FY15 FY16 FY17 Public Health Service $665,474 $371,039 $361,949 $711,830 $790,830 State/Association/Foundations $305,000 $310,850 $305,000 $190,000 $84,000 Industry Grants $0 $0 $0 $0 $0 TOTAL $970,474 $681,889 $666,949 $901,830 $874,830

56 Department of Medicine 2017 Annual Report 57 2017 total sponsored research awards

SECTION OF ENDOCRINOLOGY, SECTION OF ENDOCRINOLOGY, SECTION OF GASTROENTEROLOGY, HEPATOLOGY & NUTRITION PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE PUBLIC HEALTH SERVICE Bell, Graeme Diabetes Research and Training Center $765,734 $447,008 Bobe, Alexandria Autoimmune Diabetes: Gut Microbial Regulation in the IL 10KO Mouse Model $43,576 $0 Integrated Clinical and Basic Endocrinology Research $207,615 $16,609 Chang, Eugene Research Training in Digestive Health, Diseases, and Nutrition $384,133 $27,810 Brady, Matthew Sleep, Aging, and Circadian Rhythm Disorders $60,530 $35,108 IBD and Mucosal Inflammation, Immunology, and Micobiology of the G.I. ractT $750,000 $435,000 (Subcontract with Brigham & Women’s Hospital) Short Term Training: Health Professional Students $165,437 $13,234 Circadian Genes and Adipose Function: Impact of Chronotype,Obesity and Race $293,400 $144,403 Dietary Fat Effects of Gut Microbes, Host Immune State and Experimental Colitis $275,614 $145,732 Meal Time Effects on Metabolic Health $25,000 $14,500 Exploring Paneth Cell Peptide YY (OYY), a Unique Anti-Microbial Peptide $420,323 $164,546 (Subcontract with Brigham & Women’s Hospital) that Maintains Fungal Commensalism, in the Pathogenesis of Ileal Crohn’s Disease Dumitrescu, Alexandra Mouse Sbp2 Deficiency Models the Multi-System Syndrome $450,000 $250,978 Impact of Gut Microbes and Heat Shock Proteins on Mucosal Homeostasis and IBD $247,500 $143,550 of Human SBP2 Defects Eren, Murat Microbial Community Profiles Identify New Indicators of aterborneW Pathogens $24,554 $14,241 Ehrmann, David B-cell Function and Cognition in the Restoring Insulin Secretion $33,290 $19,308 (Subcontract with the University of Wisconsin) (RISE) Study (Subcontract with Wake Forest University) Jabri, Bana Innate and Adaptive Immunity in Celiac Disease $336,380 $195,100 Diabetes Prevention Program Outcomes Study - Phase 2 $246,781 $143,132 Pharmacological Validation of Transglutaminase 2 $118,040 $68,463 Favus, Murray Hypercalciuria and Bone Quality in the Geneti Hypercalciuric $28,582 $16,578 as a Novel Target for Celiac Disease Stone-Forming Rats (Subcontract with Rochester University) Viral Infections and Celiac Disease Pathogenesis $536,041 $119,204 Littlejohn, Elizabeth Fault-Tolerant Control Systems for Artificial Pancreas $70,835 $30,184 Kim, Karen Cook County Colon Cancer Alliance to Reignite and Enhance Screening $633,506 $183,085 (Subocntract with Illinois Institute of Technology) (Cook County CARES) Control System for Artificial Pancrease Use During and After Exercise $86,865 $33,895 Leone, Vanessa Diurnal Oscillations in Gut Microbes and Host Immunity in Health and Obesity $117,812 $8,603 Philipson, Louis Chicagoland Diabetes TrialNet Clinical Center $103,733 $52,388 Li, Yanchun (PQA1) Mechanism of Vitamin D Chemoprevention Against Colon Cancer $272,428 $158,008 Monogenic Diabetes: Next Generation Diagnosis, Treatment and Complications $296,106 $171,741 Pekow, Joel IBD Gene Mapping by Population and Clinical Subsets $3,000 $1,740 Pediatric Endocrinology Research Training $121,940 $9,755 (Subcontract with Johns Hopkins University) Rhodes, Christopher Central Control of Pancreatic Islet Function $302,523 $160,259 New Model to Dissect Molecular Pathways in IBD-neoplasia Using Human Colonoids $50,000 $30,688 Van Cauter, Eve Training Grant in Circadian and Sleep Research $89,152 $4,572 Pillai, Anjana Extracellular Non-Coding RNA Biomarkers of Hepatocellular Cancer $18,692 $11,308 ( Subcontract with Northwestern University) (Subcontract with Mayo Clinic) Rubin, David Fecal Microbiome Transplant National Registry (Subcontract ) $2,855 $1,727 Total PHS Research $3,182,086 $1,550,418 Total PHS Research $4,399,891 $1,722,039 STATE/ASSOCIATION/FOUNDATION GRANTS Greeley, Siri The Impact of Diabetes in Infancy: Clinical, Qualitative, and $125,455 $12,545 STATE/ASSOCIATION/FOUNDATION GRANTS Neurodevelopental Outcome (Juvenile Diabetes Foundation) Chang, Eugene Role of Gut Microbiota in determining Drug Efficacy and Toxicity (SFCCT) $50,000 $0 Naylor, Rochelle Personalized Genetic Medicine for MODY in a Multi-Ethnic US Population (CSCTR) $10,000 $0 Meisel, Marlies Impact of Interleukin 15 on Immune Homeostasis and the Intestinal Microbiota $58,250 $0 in the Development of Inflammatory Bowel Disease (Crohn’s and Colitis Foundation) Total State/Association/Foundation Grants $135,455 $12,545 Messer, Jeannette The Impact of Crohn’s Disease-Associated Genetic Polymorphisms on $58,250 $0 HMGB1-Mediated Inflammatory Responses in Intestinal Epithelial Cells INDUSTRY GRANTS (Crohn’s and Colitis Foundation) Bakris, George Hypertension Fellowship Program (RELYPSA) $70,000 $0 Sakuraba, Atushi Collaborative Study to Evaluate the Role of Neutrophil FC Receptor I $64,748 $12,950 Index as a New Biomarker for Mucosal Healing Total Clinical Trial Earnings $387,168 $96,792 and Histologic Remission in Inflammatory Bowel Disease Total Industry Grants $457,168 $96,792 Patients (SPARC)

Total Sponsored Research FY 13 FY 14 FY15 FY 16 FY 17 Total State/Association/Foundation Grants $231,248 $12,950 Public Health Service $9,166,194 $7,031,818 $6,241,384 $6,431,372 $4,732,504 State/Association/Foundations $841,979 $282,750 $366,566 $146,499 $148,000 Industry Grants $1,345,983 $994,932 $1,022,397 $1,222,825 $553,960 TOTAL $11,354,156 $8,309,500 $7,630,347 $7,800,696 $5,434,464

58 Department of Medicine 2017 Annual Report 59 2017 total sponsored research awards

SECTION OF GENERAL INTERNAL MEDICINE PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE Arora, Vineet Identifying Messages to Promote Value and Education (IMPROVE) of $158,228 $91,772 Generic Prescribing SIESTA (Sleep for Inpatients: Educating Staff to Act) $228,649 $18,292 Burnet, Deborah LUCENT: Leadership for Urban Primary Carye Education and Transformation $324,074 $25,926 Chin, Marshall Chicago Center for Diabetes Translation Research $380,788 $174,000 Huang, Elbert Research and Mentorship in Medical Decision Making in Diabetes $165,196 $13,216 HCIA Evaluations-Community Resource Planning (Subcontract with NORC) $26,283 $15,244 Preferences, Management and Outcomes of the Oldest Patients with Diabetes $81,940 $49,574 (Subcontract with Kaiser Permanente) Laiteerapong, Neda Linking the Legacy Effect in Type 2 Diabetes to Clinical Decision Making $163,040 $13,043 Wan, Wen Effectiveness of Shortened Interval to Postpartum Visit in Improving Attendance $7,118 $4,306 (Subcontract with Virgina Commonwealth University)

Total PHS Research $1,535,316 $405,373

STATE/ASSOCIATION/FOUNDATION GRANTS Arora, Vineet VISTA (Value, Improvement, Safety, and Team Advocates): $25,000 $0 Curriculum & Culture Change to Cultivate Physicians for the Future (American Medical Association) Chin, Marshall Reducing Health Care Disparities Through Payment and Delivery $129,995 $15,599 System Reform: Evaluation and Dissemination ( Robert Wood Johnson Foundation) Rewarding Equity Through Payment and Delivery System Reform $300,838 $36,101 (Robert Wood Johnson Foundation) Huang, Elbert Novel Education and Diabetes Pilot Program for Latinos at the $80,690 $8,069 SECTION OF GASTROENTEROLOGY, HEPATOLOGY & NUTRITION Barbara Center for Pediatric Diabetes (Helmsley/ U Denver) Innovative Clinical Care Approach for Young Adults with Type 1 Diabetes: $118,947 $11,895 PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED INDUSTRY GRANTS The DTC (Diabetes Telehealth Care Beyond High School) Study Dalal, Sushila Host Predictors of Pouchitis Development (Pfizer) $117,188 $32,812 (Helmsley/CU Denver) Jabri, Bana Evaluating the Effect of BNZ-2 Peptide (Bioniz) $7,143 $2,857 Team Clinic: An Innovative Approach to Care of Adolescents with $178,314 $17,831 Pharmacodynamic Studies in Mouse Models for CeD (Intrexon) $257,741 $103,096 Type 1 Diabetes Helath Economics and Cost Effectiveness Pekow, Joel Strategic Remodeling of the Academic Aproach to $141,382 $56,553 Analysis Proposal (Helmsley/CU Denver) Patient-Bassed Gastroenterology Research (AbbVie) Peek , Monica Shared Decision-Making Among Vulnerable Populations: $125,364 $12,036 Tissue Expression of A4B7 and MAdCAM-1 as Predictor of Response to $41,477 $16,591 The Confluence of Bioethics, Health Disparities and Therapy with Vedolizumab (Takeda Pharmaceuticals) Medical Decision-Making (Greenwall Foundation) Rubin, David International Visiting Professorship in Inflammatory $11,500 $1,150 Pincavage, Amber Teaching Resilience Skills to Students During Clinical Training (AAIM) $2,500 $0 Bowel Disease 2017-18 (Janssen Biotech) Stern, Scott I-Human Deployment (Manipal University) $66,853 $13,371 2016 IBD Visiting Professorship (Pfizer) $9,091 $909 Sulmasy, Daniel Your Health: A Sacred Matter (Templeton Foundation) $14,286 $714 2017-2018 IBD Patient Education Program (AbbVie) $59,091 $5,909 Tanksley, Audrey Opiod Prescribing & Prescription Monitoring Program $14,833 $2,967 Advanced IBD Fellows Research Meeting - $27,273 $2,727 Education for Graduate Medical Education (IDPH) December 9, 2016, Orlando, FL (Janssen Biotech) Wan, Wen RQ10 for Gastroparesis and Constipation in Parkinson’s Disease $25,195 $6,299 Advanced IBD Fellows Research Meeting - $27,273 $2,727 (Subcontract Virginia Commonwealth University) Gold Level DDW Meeting, May 2017 (Janseen Biotech) Advanced IBD Fellowship (2016-2017) (Janssen Biotech) $84,325 $8,433 Total State/Association/Foundation Grants $1,082,815 $124,882 Advanced Practice Nurse, IBD Nurse and $81,182 $8,118 INDUSTRY GRANTS Physcial Assistant IBD Immersion Program (Janssen Biotech) Peek, Monica Bridging the Gap National Program Office (Merck oundation)F $660,260 $99,039 Center of Excellence for Precesion Medicine in IBD “Chicago Promise” $465,029 $186,012 Bridging the Gap: Reducing Disparities in Diabetes Care (Merck Foundation) $71,037 $10,656 (Takeda Pharmaceuticals)

Waxman, Irving Cook Endoscopy Medical Devices (Cook Endoscopy) $6,268 $2,507 Total Industry Grants $731,297 $109,695

Total Clinical Trial Earnings $595,066 $148,766 Total Sponsored Research FY 13 FY14 FY15 FY16 FY 17 Total Industry Grants $1,931,029 $579,167 Public Health Service $2,889,542 $3,635,696 $3,245,309 $3,189,214 $1,940,689 State/Association/Foundations $2,466,988 $2,723,046 $1,934,873 $1,374,443 $1,207,697 Total Sponsored Research FY 13 FY 14 FY15 FY16 FY 17 Industry Grants $0 $0 $0 $81,997 $840,992 Public Health Service $6,005,423 $5,846,837 $5,857,444 $6,373,843 $6,121,930 TOTAL $5,356,530 $6,358,742 $5,180,182 $4,645,654 $3,989,378 State/Association/Foundations $2,205,235 $2,451,084 $2,318,729 $1,775,491 $244,198 Industry Grants $2,414,585 $2,485,488 $2,721,045 $913,065 $2,510,196 TOTAL $10,625,243 $10,783,409 $10,897,218 $9,062,399 $8,876,324

60 Department of Medicine 2017 Annual Report 61 2017 total sponsored research awards

SECTION OF GERIATRICS & PALLIATIVE MEDICINE PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE Dale, William Reducing Chemotherapy Toxicity in Older Adults (University of Rochester) $36,584 $21,219 Huisingh-Scheetz, Megan Early Frailty Biomarkers: Patterns of Activity and Energy Expenditure $144,875 $10,059 Thompson, Katherine South Side Healthy Agin Resource Experts (SHARE) Network $688,588 $25,603 Total PHS Research $870,047 $56,881 STATE/ASSOCIATION/FOUNDATION GRANTS Levine, Stacie A Primary Palliative Care Education Program to Improve Access for Patients $97,721 $0 with Cancer-Phase II (Subcontract with Coleman Foundation/ Rush University Medical Center) Hospice and Palliative Medicine Fellowship Program (Coleman Foundation) $76,500 $0

Total State/Association/Foundation Grants $174,221 $0

INDUSTRY GRANTS Total Industry Grants $0 $0

Total Sponsored Research FY 13 FY 14 FY15 FY16 FY 17 Public Health Service $175,418 $324,844 $177,767 $965,755 $926,928 State/Association/Foundations $228,046 $364,472 $418,360 $371,767 $174,221 Industry Grants $0 $0 $0 $0 $0 TOTAL $403,464 $689,316 $596,127 $1,337,522 $1,101,149

SECTION OF GENETIC MEDICINE PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE Gilad, Yoav A National iPS Cell network with Deep Phenotyping for Translational Research $50,000 $29,000 eQTL Mapping in iPSC-Derived Differentiated Cardiomyocytes $424,944 $177,816 Methods for Analysis of Regulatory Variation in Cellular Differentiation $119,622 $72,371 Hernandez, Wenndy Discovery of Genomic Copy Number Variants and Expression Quantitative Trait Loci $59,970 $0 that Affect Warfarin Dose Response in African Americans Im, Hae Kyung Genomic and Transcriptionomic Analysis of Emphysema and Subclinical ILD $15,194 $8,813 Predicted Gene Expression: High Power, Mechanism, and Direction of Effect $272,518 $158,060 Stranger, Barbara Genetics of Gene Expression in Human Left Ventricular Myocardium $33,429 $19,389 Total PHS Research $975,677 $465,449 STATE/ASSOCIATION/FOUNDATION GRANTS Total State/Association/Foundation Grants $0 $0

INDUSTRY GRANTS Total Industry Grants $0 $0

SECTION OF GENETIC MEDICINE* Total Sponsored Research FY 13 FY 14 FY 15 FY16 FY 17 Public Health Service $5,745,770 $24,501,313 7,067,316 $20,488,400 $1,441,126 State/Association/Foundations $248,301 $204,952 $0 $0 $0 Industry Grants $0 $0 $125,000 $0 $0 TOTAL $5,994,071 $24,706,265 $7,067,316 $20,613,400 $1,441,126 * FY13-16 includes Grossman and Rzhetsky. FY 17 does not.

62 Department of Medicine 2017 Annual Report 63 2017 total sponsored research awards SECTION OF HEMATOLOGY/ONCOLOGY PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE STATE/ASSOCIATION/FOUNDATION GRANTS Catenacci, Daniel PANGEA: Personalized Antibodies for GastroEsophageal Adenocarcinoma Pilot Trial $156,025 $12,482 CHEK2 Mutations as Predisposition Alleles for Inherited Hematopoietic Malignancies $50,000 $0 Churpek, Jane Definining the Role of BRCA1 in Hematopoiesis $151,800 $12,144 (Cancer Research Foundation) Dolan, Mary Genetic Susceptibility and Biomarkers of Platinum-related Toxicities (Subcontract) $71,658 $41,562 Modeling Myeloid Malignancies Mediated by Germline RUNX1, ETV6, $180,018 $19,982 Pharmacogenomics of Childhood Leukemia (Subcontract) $53,121 $30,810 and ANKRD26 Mutations (Leukemia Lymphoma Foundation) Regulation of mRNA Splicing by Intronic Genetic Variants (Subcontract) $67,854 $39,355 CBC Program Management at the University of Chicago ( Subcontract) $30,000 $0 Fleming, Gini Alliance NCORP Research Base (Subcontract) $706,296 $183,637 Hahn, Olwen Alliance Foundation Trials (Alliance Foundation Trials) $24,916 $2,492 Alliance for Clinical Trials in Oncology Operations Center (Subcontract) $2,774,255 $636,586 Han, Yoo-Jeong Genetic and Epigenetic-Factors in Breast Cancer - (Breast Cancer Foundation) $208,333 $41,667 Preclinical Investigation of Chemical and Nanoparticle-Based GR $14,050 $8,149 Huang, Rong Whole Genome Expression Based Drug Repurposing in $136,364 $13,636 Antagonism to Improve Chemotherapy Sensitivity in Ovarian Cancer(Subcontract) Metastatic Breast Cancer (Avon Foundation) Kindler, Hedy U10 - NCTN (Lead) $401,522 $232,882 Jakubowiak, Andrzej Multiple Myeloma Research Consortium Site Grant $66,667 $13,333 Larson, Richard Stopping Tyrosine Kinase Inhibitors in CMP Patients (Subcontract) $12,847 $7,451 (Multiple Myeloma Research Consortium) Le Beau, Michelle Molecular Mechanisms of Myeloid Suppressor Genes on Chromosome 5 $228,750 $132,675 Kindler, Hedy Precision Promise Clinical Trial Consortium Site Application $15,000 $0 UCCCC Cancer Center Support Grant $2,909,718 $1,687,635 (Pancreatic Cancer Action Network) A Rapid Spontaneous Murine Model of CN-AML (Subcontract) $41,500 $24,070 Le Beau, Michelle ACS Institutional Research Grant -(American Cancer Society) $90,000 $0 Olopade, Olufunmilayo Basic Medical Research Training in Oncology $372,254 $27,620 Lim-Seiwert, Tanguy Synergy of Pembrolizumab Anti-PD-1 Immunotherapy with $22,727 $2,273 Conference and Workshop on New Frontiers in Diagnosis, $10,000 $0 Chemotherapy for Poorly Chemo-Responsive Salivary Gland Tumors Screening, and Management of Inherited Cancer Syndromes ( Adenoid Cystic Carcinoma Research Foundation ) Developing an Oncology Workforce for the 21st Century $473,459 $37,877 Luke, Jason Determination of Tumor-Intrinsic Somatic Alterations Associated with the $37,500 $0 Returning Genetic Research Panel Results for $104,289 $60,488 ( Adenoid Cystic Carcinoma Research Foundation ) Breast Cancer Susceptibility(Subcontract) Nanda, Rita Proposal for a Partnership Between the Breast Cancer Research Consortium $20,833 $4,167 Cancer Genetics Professional Education in a $25,000 $2,000 “TBCRC” and the Komen Foundation ( Subcontract) Global Community of Practice (Subcontract) The Breast Cancer Clinical Trials Consortium (Breast Cancer Foundation) $10,417 $2,083 Patnaik, Akash Targeting the Metavolome and PI3K/AMPK/mTOR $72,978 $5,838 Olopade, Olufunmilayo Developing an Interdisciplinary Network for Sickle Cell Studies in Nigeria $92,592 $7,408 Signaling Pathways in Advanced Prostate Cancer (Doris Duke Charitable Foundation) “Perturbing DNA Repair Pathways to Enhance Immune-responsiveness $40,000 $0 Functional Analysis of SNPs Associated with Estrogen Receptor Negative $57,500 $5,750 in Prostate Cancer ( Subcontract with Northwestern University)” Breast Cancer Using CRISPR-Cas9 Technology (Doris Duke Charitable Foundation ) Ratain, Mark Clincical Therapeutics $392,436 $31,395 Genomic Appraches for Primary Prevention of Breast Cancer $80,000 $0 Sharma, Manish Genomic Prediction Tools Developed Using Phenotypes $176,867 $14,149 (American Cancer Society) from Disease Progression Models Genomics, Metabolomics and Epigenetic Regulation in Breast Cancer $122,728 $12,272 Smith, Sonali SWOG Network Group Operations Center of the NCTN(Subcontract) $11,603 $6,730 (Falk Foundation) Stadler, Walter The Prostate Cancer Clinical Trials Consortium: Application for $100,000 $58,000 Implementing Evidence Based Interventions to Reduce Breast Cancer Mortality) $208,333 $41,667 Coordinating Center with Clinical Research Site Option(Subcontract) in Low Resource Settings (Breast Cancer Foundation SPORE in Prostate Cancer (Subcontract) $285,186 $165,408 Olson, Brian Targeting Resistance to Angrogen Deprivation Therapy Using $37,500 $0 Stock, Wendy Center for Precision Medicine in Leukemia(Subcontract) $81,274 $47,140 Ummunotherapies Targeting the Androgen Receptor (Prostate Cancer Foundation) Thirman, Michael Instructive Role of MLL Fusion Proteins in $502,591 $106,587 Patnaik, Akash Combinatorial Immunotherapy Strategies to Reverse Immunosuppression within $500,000 $0 Lineage Determination and Leukemogenesis PTEN-Deficient Advanced Prostate Cancers (Prostate Cancer Foundation) Ionizing Ratiation-Induced Hematological Malignancies(Subcontract) $36,000 $22,320 PCF Young Investigator Award (Prostate Cancer Foundation) $53,126 $0 Wickrema, Amittha Improving HbF Induction by Better Selection and $18,987 $11,013 Perturbing DNA Repair Pathways to Enhance Immune-Responsiveness $50,000 $0 Inhibition of Epigenetic Targets(Subcontract) in Prostate Cancer (Cancer Research Foundation) Pettit, Kristen Identifying Pharmacogenomic Variants Associated with Response to Idelalisib $47,500 $2,500 Total PHS Research $10,292,320 $3,646,003 (Conquer Cancer Foundation) Polite, Blase Current State Assessment and Pilot of Supportive Cancer Care Processes $101,000 $0 STATE/ASSOCIATION/FOUNDATION GRANTS (Distress, Palliative, Hospice Referral and Survivorship Care) at Agyeman, Abena Using Hsp90 Inhibitors to Treat Triple Negative Breast Cancer (Komen Foundation) $60,000 $0 The University of Chicago Medicine (Coleman Foundation) Conzen, Suzanne Use of Selective GR Antagonists in Castration-Resistant Prostate Cancer $500,000 $0 Riedell, Peter ACP-196 + Immunochemotherapy and Autologous Stem-Cell $5,984 $0 (Prostate Cancer Foundation) Transplant in Mantle Cell Lymphoma (Leukemia Lymphoma Foundation) Curran, Emily Investigating the Role of the STING Pathway in Hereditary Malignancies $37,500 $0 Stock, Wendy TOPK (T-LAK Cell-Originated Protein Kinase): $181,818 $18,182 (Cancer Research Foundation) A New Target for FLT3 Mutated AML (V Foundation) Targeting the STING Pathway as Immunotherapy for Acute Myeloid Leukemia $47,500 $2,500 Sweis, Randy Facilitating Immunotherapy Responses in Non-T $55,000 $0 (Conquer Cancer Foundation) Cell-Inflamed Bladder Cancer (American Association for Cancer Research) Dolan, Mary Susan G. Komen Foundation Grant $135,000 $0 Wickrema, Amittha Therapeutic Targeting of Anemia in MDS by $180,018 $19,982 Drazer, Michael Defining Leukemogenic Mechanisms in Hereditary Hematologic Malignancies $100,000 $0 Modulation of DOCK4 Pathway (Leukemia Lymphoma Foundation) (Damon Runyon Cancer Foundation)

Fleming, Gini DNA Repair Therapies for Ovarian Cancer (Subcontract) $143,608 $15,956 Total State/Association/Foundation Grants $4,058,118 $262,214 Galanina, Natalie A Combination of BTK and HSP90 Inhibition in Relapsed NHL $5,000 $0

(Leukemia Lymphoma Foundation) Godley, Lucy Identification of Germline Predisposition Syndromes in Young MDS Patients $181,818 $18,182 (Taub Foundation) Using Insights from Hypoxia-Induced Changes in 5-Hyfroxymethylcytosine to $181,818 $18,182 Improve MDS Treatment (Edward P. Evans Foundation)

64 Department of Medicine 2017 Annual Report 65 2017 total sponsored research awards SECTION OF HOSPITAL MEDICINE PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE Chattopadhyah, Ishanu ZeD: Zero-Knowledge Discovery Using Data Smashing $126,583 $73,417 SECTION OF HEMATOLOGY/ONCOLOGY Edelson, Dana 13th International Conference on Medical Emergency Teams $9,000 $0 PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED and Rapid Response Systems INDUSTRY GRANTS Gibbons, Robert A New Statistical Paradigm for Measuring Psychopathology Dimensions in Youth $620,950 $121,399 Curran, Emily Immunologic Role of DDX41 in Development of $59,091 $5,909 Bipolar-Schizophrenia Network for Intermediate Phenotypes(Subcontract) $46,496 $24,184 Hereditary Hematologic Malignancies (Gilead Science) Optimizing Youth Suicide Risk Screening in the $123,157 $71,431 Jakubowiak,Andrzej Investigation of the MCL-1 Inhibitor AMG 176 in Multiple Myeloma (Amgen) $35,714 $14,286 Emergency Department (Subcontract) Kline, Justin To Define and Overcome Immunoregulatory Mechanisms Activated in $75,269 $30,108 Peer-Led Suicide Prevention: Promoting Healthy Role Transitions for $17,432 $10,111 Leukemia-Bearing Mice Treated with STING Agonist Immunotherapy (Merck) Military Personnel (Subcontract) Lim-Siewert, Tanguy Evaluation of Synergistic Immunotherapy Combinations in (fresh) $136,756 $54,702 Kass, Andrea Analysis of Behavioral Interventions for Pediatric Obesity $60,394 $0 Patient-Derived Head-and-Neck Cancer Thin Sections (Immune Histoculture) Meltzer, David A Novel Big-Data Screening Tool to Identify and Reduce CRN $275,000 $159,500 (Bristol Myers Squibb) African American Cardiovascular Pharmacogenetic Consortium (Account): $328,900 $190,764 Luke, Jason Development and Validation of Gene Expression Profiles Associated with $217,488 86,995 Discovery and Translation(Subcontract) Monocyte/Macrophage Infiltration and T Cell Ummunosuppression in Cancer African American Cardiovascular Pharmacogenetic Consortium (Account): $394,778 $228,971 (Array Bio) Discovery and Translation(Subcontract) Gene Expression Analysis of Melanoma Biopsy from $108,572 $43,429 Changing Long-Term Care in America: Policies, Markets, $24,165 $14,015 Clinical Trian CMP-001-001 (Checkmate) Strategy & Outcomes (Subcontract) Nakamura, Yusuke Development of New Targeted Cancer Therapies (Onco Therapeutics) $641,248 $256,499 CMS Practice Transformation Network(Subcontract) $465,574 $153,639 Patnaik, Akash Perturbing DNA Repair Pathways to Enhance Immune-Responsiveness $312,941 $125,176 Health Services Training Grant Subaward $236,658 $15,093 in Prostate Cancer (Bristol Myers Squibb) (Subcontract with Northwestern University ) Szmulewitz, Russell Preclinical Investigation of ABT-075 in the Treatment of $150,000 $60,000 MD/PhD Program in Medicine, the Social Sciences and Aging $197,304 $9,064 High Glucocorticoid-Receptor Expressing Enzalutamide-Resistant Short Term Aging-Related Research Program $62,046 $4,964 Castration-Resistant Prostate Cancer (AbbVie) The University of Chicago Patient Centered Outcome $598,738 $47,899

Research K12 Training Program Total Clinical Trial Earnings $15,394,170 $3,848,543 Press, Valerie Video vs TTG Respiratory Inhaler Technique Assessment and Instruction (V-TRAIN) $176,800 $14,144 Total Industry Grants $17,131,249 $4,525,647 Saunders, Milda Patient Referral and Education Program Prior to $176,042 $14,083

Renal Replacement Therapy (PREP RRT) Total Sponsored Research FY 13 FY 14 FY15 FY 16 FY 17

Public Health Service $24,261,953 $18,429,021 $19,723,352 $15,721,229 $13,938,323 Total PHS Research $3,940,017 $1,152,678 State/Association/Foundations $6,961,474 $5,136,773 $6,921,685 $3,220,776 $4,320,332 Industry Grants $10,426,362 $15,648,868 $16,364,357 $17,059,908 $21,656,896 STATE/ASSOCIATION/FOUNDATION GRANTS TOTAL $41,649,789 $39,214,662 $43,009,394 $36,001,913 $39,915,551 Martin, Shannon Consulting Wisely - Applying the Principle of High Value Care $2,500 $0 to the Practice of Requesting a Consult (AAIM) Meltzer, David Capricorn - Phase II (PCORI/Chicago Community Trust) $172,193 $68,877 Comprehensive Care, Community and Culture Program $447,299 $53,676 (Robert Wood Johnson Foundation) Effects of Oral Health on Systemic Health, Oral Health $433,834 $0 & Healthcare Programs (GERF) Longitudinal Effects of the Comprehensive Care Physicians Program $176,462 $17,646 (Donaghue Foundation) PCORnet Observational Study Agreement Studies (PCORnet Antibiotic Study) $6,677 $1,335 (PCORI/Chicago Community Trust) PCORnet Observational Study Agreement Study Order #1 $4,975 $995 (PCORnet Bariatric Study OBS-1505-30683) (PCORI/Chicago Community Trust) Press, Valerie Coordinated Healthcare Interventions for Childhood Asthma Gaps in Outcomes $31,523 $12,609 (CHICAGO) Trial (PCORI/University of Illinois at Chicago Ruhnke, Gregory Measuring the Impact of Accreditation on Diagnostic Accuracy and $86,303 $34,521 Health Outcomes in Echocardiography (IAC)

Total State/Association/Foundation Grants $1,361,766 $189,659

INDUSTRY GRANTS Total Clinical Trial Earnings $65,254 $16,315 Total Industry Grants $65,254 $16,315

Total Sponsored Research FY 13 FY 14 FY 15 FY 16 FY 17 Public Health Service $4,637,017 $4,207,548 $4,519,439 $3,666,163 $5,092,695 State/Association/Foundations $163,955 $405,711 $1,444,109 $1,177,457 $1,551,425 Industry Grants $195,311 $0 124920 $371,813 $81,569 TOTAL $4,996,283 $4,613,259 $6,088,468 $5,215,433 $6,725,689

66 Department of Medicine 2017 Annual Report 67 2017 total sponsored research awards

SECTION OF INFECTIOUS DISEASES AND GLOBAL HEALTH SECTION OF NEPHROLOGY PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE PUBLIC HEALTH SERVICE Eavou, Rebecca Comprehensive PrEP Retention in Care (PrEP-RC)(Subcontract) $162,652 $16,265 Chapman, Arlene A Metabolomic Approach to Discovering Markers for $56,120 $32,550 McNulty, Moira Employing eSBI in a Community-Based HIV Testing Environment $55,716 $32,315 ADPKD Progression(Subcontract) for At-Risk Youth(Subcontract) Kansas PDK Research and Translation Core Center(Subcontract) $29,703 $13,464 Pho, Mai Tuyet Optimizing Patient-Oriented Outcomes for Chronic Hepatitis C $156,228 $90,612 Consortium for Radiologic Imaging Studies of Polycystic $61,984 $35,486 Pitrak, David Sustainable Health Center Implementation PrEP Pilot (SHIPP) Study(Subcontract) $2,273 $227 Kidney Disease (CRISP) IV: Prognosis for End-Stage Renal Disease University of Chicago Expanded HIV Testing and Linkage to Care for $1,006,695 $93,305 and Biomarker Validation (Subcontract) Disproportionately Affected Populations in Healthcare Settings on Hassan, Hatim Calcium Oxalate Kidney Stones: Pathogenesis of Obesity-Associated Hyperoxaluria $217,500 $126,150 the South Side and West Side of Chicago(Subcontract) Kohn, Orly Longitudinal Changes in Intra-Renal Oxygenation by BOLD MRI in $45,629 $23,673 Ridgway, Jessica Anti-Infective Stewardship Using the Wisca Tool in the $32,879 $19,070 Patients with CKD(Subcontract) Electronic Medical Record(Subcontract) Koyner, Jay Intrarenal Oxygenation: An Early Marker for Risk of Developing AKI(Subcontract) $6,238 $3,775 CDPH Data to Care(Subcontract) $63,864 $6,386 Predictive Modeling for Retention in HIV Care(Subcontract) $44,242 $26,766 Total PHS Research $417,174 $235,098 Schneider, John Accelerating PrEP Diffusion Through Network Change Agents $390,291 $102,396 Center for Prevention Implementation Methodology for $49,919 $28,953 INDUSTRY GRANTS Drug Use and HIV(Subcontract) Total Clinical Trial Earnings $198,843 $49,711 Comprehensive High Impact HIV Prevention Projects for $230,691 $0 Total Industry Grants $198,843 $49,711 Community-Based Organizations(Subcontract) HIV Intervention Models for Crimincal Justice Involved Substance-Using Black MSM $506,033 $172,149 Total Sponsored Research FY 13 FY 14 FY 15 FY 16 FY 17 iMAN: Integrated Molecular & Affiliation Network Analysis of $14,489 $8,404 Public Health Service $3,026,468 $2,623,945 $3,268,846 $1,931,796 $652,272 HIV Transmission - (Subcontract) State/Association/Foundations $290,800 $6,900 $404,067 $687,377 $0 Impact of Neighborhoods and Networks on HIV Risk and Care $24,681 $1,974 Industry Grants $99,167 $114,900 $313,974 $279,439 $248,554 Insurance Coverage Expansion (ICE): A Collaboration to Increase and $254,260 $106,310 TOTAL $3,416,435 $2,745,745 $3,986,887 $2,898,612 $900,826 Strengthen Access to Care Among Men and their Networks Next Generation Partner Notification and Intervention Services $150,000 $87,000 PrEP Uptake and Adherence Among Young Black MSM: ) $102,356 $61,925 Neighborhood and Network Determinants(Subcontract Preventing HIV Transmission by Recently-Infected Drug Users(Subcontract) $73,231 $40,247 Social and Cultural Influences on Cardiovascular Risk Factors $19,249 $11,164 in South Asians (Subcontract) Third Coast Center for AIDS Research(Subcontract) $44,443 $25,777 YMAP: Young Men’s Affiliation Project of HIV Risk & Prevention Venue(Subcontract) $25,546 $14,817 Sherer, Renslow AIDS Education and Training Centers Program(Subcontract) $18,519 $1,481

Total PHS Research $3,428,257 $947,543 STATE/ASSOCIATION/FOUNDATION GRANTS Eavou, Rebecca South Side PrEP Project (S2P2) (Chicago Department of Public Health) $136,364 $13,636 South Side Social Network Strategy (S4 Program) $136,364 $13,636 (Chicago Department of Public Health) Schneider, John Paragon VI: Syndicate Ball (Chicago Department of Public Health)(Subcontract) $4,000 $0 Sherer, Renslow WUMER Project ( Sino American Medical School, Wuhan University) $1,065,719 $0

Total State/Association/Foundation Grants $1,342,447 $27,272

INDUSTRY GRANTS Ridgway, Jessica Rapid Response Team and Algorithmic HIV Post-Test $135,657 $13,566 Counseling in High-Volume Settings (Gilead Sciences) Schneider, John Young Men’s Affiliation Project of HIV Risk and Prevention Venue (YMAP) $30,574 $12,230 (Gilead Sciences(Subcontract)

Total Clinical Trial Earnings $360,079 $90,020 Total Industry Grants $526,310 $115,816

Total Sponsored Research FY 13 FY 14 FY 15 FY 16 FY 17 Public Health Service $2,621,169 $1,185,772 $2,006,111 $4,939,253 $4,375,800 State/Association/Foundations $739,542 $580,038 $1,582,822 $1,533,603 $1,369,719 Industry Grants $2,270,925 $1,362,267 $1,476,058 $950,764 $642,126 TOTAL $5,631,636 $3,128,077 $5,064,991 $7,423,620 $6,387,645

68 Department of Medicine 2017 Annual Report 69 2017 total sponsored research awards

SECTION OF PULMONARY/ CRITICAL CARE PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED PUBLIC HEALTH SERVICE INDUSTRY GRANTS Birukova, Anna Differential Mechano-Signaling in Vacuslar Endothelium by $250,000 $145,000 Hogarth, Douglas Interventional Pulmonology Fellowship at the University of Chicago $30,000 $0 Varying Degrees of Mechanical Stretch (Boston Scientific) Churpek, Matthew Predicting In-Hospital Cardiac Arrest Using Electronic Health Record Data $151,800 $12,144 Interventional Pulmonology Fellowship at the University of Chicago (Covidien) $22,727 $2,273 Sepsis Early Prediction and Subphenotype Illumination Study (SEPSIS) $272,481 $144,964 Interventional Pulmonology Fellowship at The University of Chicago (Pinnacle) $27,273 $2,727 Guzy, Robert Mechanism of Fibroblast Growth Factor 2-Mediated Alveolar Epithelial Repair $151,800 $12,144 Murgu, Septimiu Interventional Pulmonology Fellowship at the University of Chicago (Cook Medical ) $9,091 $909 Hamanaka, Robert Metabolic Regulation of Epidermal Homeostasis $78,488 $6,279 Howell, Michael Quantifying a Vital Symptom: Large-Scale Inpatient $11,375 $6,598 Total Clinical Trial Earnings $468,900 $117,225 Dyspnea Measurement (Subcontract) Total Industry Grants $557,991 $123,134 Knutson, Kristen Home Sleep and Circadian Phase: Mediators of Racial Disparities in Diabetes Risk $77,542 $33,135 Morning Light Treatment at Home to Improve Glucose Metabolism in $168,600 $81,886 Total Sponsored Research FY 13 FY 14 FY 15 FY 16 FY 17 Dyspnea Measurement (Subcontract) Public Health Service $11,124,683 $12,594,100 $14,426,748 $17,680,416 $9,940,793 Mokhlesi, Babak TODAY2 Phase (T2P2): Long-Term Post-Intervention Follow-Up Study(Subcontract) $30,323 $17,587 State/Association/Foundations $584,146 $71,971 $316,361 $818,564 $396,894 Mutlu, Gokhan Macrophage Responses to Epithelial Dysfunction $56,018 $32,490 Industry Grants $323,429 $874,585 $756,872 $855,821 $681,125 Promote Lung Fibrosis in Aging(Subcontract) TOTAL $12,032,258 $13,540,656 $15,499,981 $19,354,801 $11,018,812 Particulate Matter-Induced Changes in DNA Methylome and Transcriptome $395,570 $225,951 The Role of Alveolar Macrophage Beta-2 Adrenergic Receptors in Acute Lung Injury $400,000 $232,000 Noth, Imre Architectural Structure and Regulation of TOLLIP in IPF $489,865 $284,122 Study of Co-Trimoxazole and Proton Pump Inhibition $20,246 $11,743 Using Pragmatic Design in Idiopathic Pulmonary Fibrosis - CleanUP - IPF(Subcontract) Olopade, Christopher Summer Program to Increase Diversity in $129,700 $10,376 Biomedical Research & Physician Workforce Solway, Julian Chicagoland Metropolitan Asthma Net Consortium $39,980 $22,389 Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes $505,202 $273,830 Preclinical Development of Myosolvins, a New Class of Medicine for Asthma $1,498,987 $209,143 TET1-Mediated 5-Hydroxymethylcytosine Modification and $25,000 $14,500 Airway Hyperresponsiveness (Subcontract) Training of Junior Faculty for Careers in Omics of Lung Diseases $313,797 $25,104 Sperling, Anne Functional Genomics of IL-33 Expression and Asthma Risk $524,191 $294,622 Human Lung T Cell Subsets in Disease $125,000 $72,500 IRF4+ Respiratory Dendritic Cells in Type 2 Inflammatory Responses $250,000 $147,245 Research Training in Respiratory Biology $668,068 $49,806 Tasali, Esra Sleep Extension to Reduce Diabetes and Obesity Risk $388,022 $175,090 Verhoef, Philip Type 2 Immune Responses Protect Against the Morbidity and Mortality of Sepsis $151,800 $12,144 White, Steven Airway Inflammation and HLA-G in Asthma $112,493 $37,507 Wu, David Mechanical Regulation of Vascular Metabolism $64,146 $0

Total PHS Research $7,350,494 $2,590,299 STATE/ASSOCIATION/FOUNDATION GRANTS

Guzy, Robert Cell-Specific Functions of Fibroblast Growth actorF Signaling In $120,000 $12,000 Lung Injury and Pulmonary Fibrosis (American Heart Association) Krishack, Paulette Type 2 Inflammatory Response rotectsP Against Staphylococus $48,600 $0 Aureus Induced Sepsis (American Heart Association-Midwest) Naureckas, Edward American Lung Association Asthma Clinical Research Network $19,246 $0 (American Lung Association/Northwestern University) Award for a Mental Health Coordinator (Cystic Fibrosis Foundation) $50,000 $4,000 Cystic Fibrosis Foundation Practice Guidelines Update (Cystic Fibrosis Foundation) $26,276 $0 Nigdelioglu, Recep Alveolar Macrophage Beta2-Adrenergic Receptors in Acute Lung Injury $60,272 $0 (American Heart Association-Midwest) Noth, Imre PFF Care Center Network Charter Agreement (Pulmonary Fibrois Foundation) $5,652 $848 Patel, Bhakti Impact of Early Mobilization on Insulin Resistance and ICU-Acquired Weakness $50,000 $0 (Francis B. Parker Foundation)

Total State/Association/Foundation Grants $380,046 $16,848

70 Department of Medicine 2017 Annual Report 71 2017 total sponsored research awards

SECTION OF RHEUMATOLOGY TOTAL SPONSORED RESEARCH FOR THE DEPARTMENT OF MEDICINE PRINCIPAL INVESTIGATOR TITLE OF FUNDED GRANT ANNUAL DIRECT COSTS AWARDED ANNUAL INDIRECT COSTS AWARDED FY 13 FY 14 FY 15 FY 16 FY 17 PUBLIC HEALTH SERVICE Grand Total Alegre, Maria-Luisa Impact of Microbiota on Alloimmune Responses in Transplantation $250,000 $139,432 Public Health Service $83,112,280 $91,532,042 $79,503,794 $93,449,876 $63,889,941 Clark, Marcus Autoimmunity Center of Excellence Clinical Research Program - $261,364 $146,023 State/Association/Foundations $16,102,385 $13,521,116 $16,926,325 $12,330,941 $11,199,945 Collaborative Project (Subcontract) Industry Grants $19,068,843 $22,810,425 $24,457,913 $23,558,456 $29,369,759 BRWD1 in Adaptive Humoral Immunity $150,000 $91,875 Immune Tolerance Network (Subcontract) $2,874 $1,739 Total $118,283,508 $127,863,583 $120,888,032 $129,339,273 $104,459,645 In Situ Adaptive Immunity in Human Lupus Tubulointerstitial Nephritis $220,000 $127,600 Medical Scientist National Research Service Award $1,124,148 $51,292 Regulation of Ig-Kappa Recombination During B Lymphopoiesis $297,607 $164,244 University of Chicago Autoimmunity Center of Excellence $237,911 $137,988 Gounari, Fotini How Beta-Catenin Expands Foxp3+RORgammat+ $329,450 $122,111 Pro-Inflammatory -RegulatoryT Cells Liarski, Vladimir Characterizing In Situ T Cell: Dendritic Cell Networks $149,894 $11,992 Pro-Inflammatory -RegulatoryT Cells Wilson, Patrick Impact of Prior Influenza Exposures on Antibody Repertoires to $18,089 $10,491 New Viral Strains(Subcontract) Mechanisms of Broadly Neutralizing Humoral Immunity $344,519 $199,821 Against Influenza Viruses(Subcontract) NIAID Centers of Excellence in Influenza Research and Surveillance (Subcontract) $383,726 $222,561 Studies of Human B Cell Tolerance, from a Humanized Mouse $33,536 $19,451 Model to Human Beings(Subcontract) System Biological Analysis of Innate and Adaptive Responses $86,585 $50,219 to Vaccination (Subcontract) Toward a Universal Influenza Virus Vaccine (Subcontract) $243,756 $135,811 Vaccine Induced Immunity in the Young and Aged (Subcontract) $66,537 $38,591

Total Public Health Service Grants $4,199,996 $1,671,241 STATE/ASSOCIATION/FOUNDATION GRANTS Gounari, Fotini Define the Properties of athogenicP ROR¿/Foxp3 Double Positive Regulatory $45,444 $0 T Cells in Colon Cancer (American Association of Immunologists) Lei, Yuk Man The Role of Microbiota in Allograft Rejection (American Heart Association -Midwest) $25,950 $0

Total State/Association/Foundation Grants $71,394 $0

INDUSTRY GRANTS Total Clinical Trial Earnings $23,121 $5,780 Total Industry Grants $23,121 $5,780

Total Sponsored Research FY 13 FY 14 FY 15 FY 16 FY 17 Public Health Service $4,894,918 $4,771,826 $6,847,760 $5,846,364 $5,871,237 State/Association/Foundations $371,144 $266,759 $206,759 $381,356 $71,394 Industry Grants $338,446 $262,105 $179,652 $28,901 $28,901 TOTAL $5,604,508 $5,300,690 $7,234,171 $6,256,621 $5,971,532

72 Department of Medicine 2017 Annual Report 73 2017 research awards PHS 2017 Sponsored Awards State/Assoc./Found. 20172017 Sponsored Sponsored Awards Awards PHS PHS 2017 Sponsored Awards By Section State/Assoc./Found.State/Assoc./Found.Industry By BySection Section IndustryIndustry FY 13 em ipsum PHS S83.1M LoremLor ipsum State/Assoc./Found. $1 Million $50 Million $105 Million $16.1M $1 Million$1 Million $50 Million$50 Million $105 Million$105 Million Industry $19.1M total $118.3M CardiologyCardiologyCardiology $1.48M$1.48M$0.45M$0.45M$2.00M$1.48M$2.00M total $3.93M total $0.45M $3.93M $2.00M total $3.93M ComputationalComputationalComputational BiomedicineBiomedicine Biomedicine $2M $0.93M$2M $0.93M$0.10M$0.10M total$2M $3.03M total $0.93M $3.03M $0.10M total $3.03M and Biomedicaland Biomedical Data Science Data Science and Biomedical Data Science DermatologyDermatology $0.8M $0.08M$0.8M $0.08M total $0.88M total $0.88M Dermatology $0.8M $0.08M total $0.88M $4.6M $0.25M$4.6M $0.25M total $4.85M total $4.85M Emergency Emergency Medicine Medicine FY 14 Endocrinology,Endocrinology, DiabetesEmergency Diabetes and Metabolism andMedicine Metabolism $4.7M $0.2M$4.7M $.6M$0.2M total $.6M $5.40M total$4.6M $5.40M $0.25M total $4.85M $91.5M Endocrinology,Gastroenterology, DiabetesGastroenterology, and HepatologyMetabolism Hepatology $6.10M$6.10M $0.24M $0.24M$2.50M$2.50M total $4.7M$8.84M total $8.84M $0.2M $.6M total $5.40M $13.5M and Nutritionand Nutrition $22.8M FY 15 Gastroenterology,GeneralGeneral Internal InternalHepatology Medicine Medicine $1.90M$1.90M $1.20M $1.20M$0.80M$6.10M$0.80M total $3.90M total $0.24M $3.90M $2.50M total $8.84M total $127.8M and Nutrition $79.5M GeneticGenetic Medicine Medicine $1.40M$1.40M total $1.40M total $1.40M $17.0M General Internal Medicine $1.90M $1.20M $0.80M total $3.90M $24.4M GeriatricsGeriatrics and Palliative and Palliative Medicine Medicine $0.93M$0.93M $0.17M $0.17M total $1.10M total $1.10M total $120.9M Hematology/OncologyGeneticHematology/Oncology Medicine $14M $4.30M$14M $4.30M$21.60M$21.60M total $39.80M total $39.80M$1.40M total $1.40M

Geriatrics and PalliativeHospitalHospital Medicine Medicine Medicine $5.10M$5.10M $1.60M $1.60M$0.08M$0.08M total $6.78M total$0.93M $6.78M $0.17M total $1.10M InfectiousInfectious Diseases Diseases and Global and HealthGlobal Health $4.4M $1.40M$4.4M $1.40M$0.60M$0.60M total $6.40M total $6.40M Hematology/Oncology $14M $4.30M $21.60M total $39.80M NephrologyNephrology $0.65M$0.65M $0.25M $0.25M total $0.90M total $0.90M Hospital Medicine $5.10M $1.60M $0.08M total $6.78M Pulmonary/CriticalPulmonary/Critical Care Care $10M $0.4M$10M $0.68M$0.4M $0.68M total $11.08M total $11.08M

FY 16 Infectious Diseases andRheumatology GlobalRheumatology Health $5.90M$5.90M $0.07M $0.07M$0.03M$4.4M$0.03M total $6M$1.40M total $6M $0.60M total $6.40M $93.5M Nephrology $0.65M $0.25M total $0.90M $12.3M FY 17 Total Total $23.5M $63.90M$63.90M $11.20M $11.20M$29.40M$29.40M total $104.5 total $104.5 $63.9M Pulmonary/Critical Care $10M $0.4M $0.68M total $11.08M total $129.3M $11.2M $29.4M Rheumatology $5.90M $0.07M $0.03M total $6M total $104.5M Total $63.90M $11.20M $29.40M total $104.5

74 Department of Medicine 2017 Annual Report 75