powerful connections CHAIRMAN’S MESSAGE I am delighted to present to you the 2017 Department of Medicine Annual Report entitled table of contents “Powerful Connections”. Connections that bridge our programs and people are so important to enhancing our missions of discovery, innovative patient care and mentorship. Connections are fun- damental to science and medicine. Across departments scientists connect scientific findings from bench to bedside and back with the goal of improving patient outcomes and developing better ther- apies, and our medical educators channel their knowledge to our trainees to enhance the learning environment and prepare them for their academic careers. Chair’s message 1 Cardiology 14 Some examples from the last year include: • The appointment of four new administrative Clinically, the Department of Medicine continued Organization 2 Computational Biomedicine • The discovery that the onset of Celiac disease leaders, Matthew Sorrentino, MD as Vice Chair to impact patient care with new initiatives and and Biomedical Data Science 16 could be triggered by prior Reovirus infection for Clinical Operations, Steven White, MD as connections in the community, city, and region. Medicine by the Numbers 3 (Jabri) Associate Vice Chair for Appointments and This included the expansion of the Department’s Dermatology 18 Promotions, Anne Sperling, PhD as Associate clinical imprint at the University of Chicago Special Awards 4 • The preclinical development of novel approach- Vice Chair for Research and Julie White as Medicine’s new offsite practices in Orland Park Emergency Medicine 20 es to prostate cancer immunotherapy using a Executive Administrator and Chicago’s South Loop, at Ingalls Hospital Faculty Highlights 6 tyrosine kinase inhibitor to infiltrate and clear the as well as at satellite clinics in Indiana. The Endocrinology, Diabetes and Metabolism 22 tumor (Patnaik) • The creation of the new Section of Department also continues to lead efforts relating Research Programs Overview 8 Computational Biomedicine and Biomedical to the growth of emergency and trauma services at Gastroenterology, Hepatology • The expansion of the cellular and stem cell Data Science under the leadership of Robert UCM, and looks forward to the opening of the new Clinical Programs Overview 10 and Nutrition 24 transplant program with new targeted cellular Grossman, PhD and Andrey Rzhetsky, PhD Emergency Department in January, 2018 and the therapies, such as chimeric antigen receptor new Trauma Center in May, 2018. Education Programs Overview 12 General Internal Medicine 26 T-cell (CAR T) infusions, to improve the • The appointment of Esra Tasali, MD as responsiveness of cancer the director of the newly structured Sleep I am very proud of the Department of Medicine’s Genetic Medicine 28 Research Center contributions over the past year and the • Determining that helmet ventilation helps critically remarkable advances our faculty have achieved in Geriatrics and Palliative Medicine 30 ill patients breathe better (Patel, Hall, Kress) • The recognition of four of our faculty with patient care, research and education. I thank them named professorships from the University: for their dedication to our tripartite mission. Hematology/Oncology 32 • The creation of a new classification of common Thomas Gajewski, MD, PhD as the AbbVie diseases based on how often they occur among Foundation Professor; Robert Grossman, PhD Hospital Medicine 34 genetically-related individuals (Rzhetsky) as the Frederick H. Rawson Professor; Everett E. Vokes, MD Sonali Smith, MD as the Elwood V. Jensen John E. Ultmann Professor Infectious Diseases and Global Health 36 • The discovery that pre-existing Type 2 immune Professor and Nir Uriel, MD as the Louis Chairman, Department of Medicine activation protects against sepsis (Verhoef, Block Professor. Physician-in-Chief, University of Chicago Medicine & Biological Sciences Nephrology 38 Solway, Sperling) • National and international recognition for the Pulmonary/Critical Care 40 • New insights on improving clinical learning and work of many individuals including cancer patient care with the development of an online disparities and global health (Olufunmilayo Rheumatology 42 learning network to teach value based care, and Olopade, MD), bioethics (Mark Siegler, MD), improved strategies for inpatient handoffs (Arora) novel educational systems (Vineet Arora, MD), Residents and Fellows 44 immunotherapy (Thomas Gajewski, MD, PhD) Other noteworthy departmental highlights Select High Impact Publications 50 from this past year include: • National recognition as one of the safest • The appointment of two new section chiefs: hospitals in the country with the University of Committee Highlights 52 Vesna Petronic Rosic, MD as Chief, Section of Chicago Medicine garnering straight A’s for Dermatology, and Stacie Levine, MD as Chief, the 11th consecutive time by the prestigious Section of Geriatrics and Palliative Medicine and independent Leapfrog Group. 2017 Annual Report 1 department of medicine department of medicine organization by the numbers Chairman, Department of Medicine Everett E. Vokes, MD 2017 Executive Vice Chair of Appointments & Promotions Dorothy Hanck, PhD Committee: Vice Chair of Education John McConville, MD Vice Chair of Faculty Development Deborah Burnet, MD Vice Chair of Research Julian Solway, MD Vice Chair of Research (Basic) Bana Jabri, MD, PhD Associate Vice Chair – Appointments & Promotions Steven White, MD* Associate Vice Chair – Outpatients Operations Lisa Vinci, MD 15 303 Associate Vice Chair – Quality Andrew Davis, MD SUBSPECIALTY Associate Vice Chair – Research Anne Sperling, PhD* CLINICAL AND Associate Vice Chair – SECTIONS Urban Health Initiative/EMR & Transplant Edward Garrity, MD RESEARCH Executive Administrator Julie J. White RESEARCH FACULTY Associate Executive Administrator James Manthey ACTIVITY Section Cardiology James Liao, MD Chief Council: Computational Biomedicine & Biomedical Data Science Robert Grossman, PhD & Andrey Rzhetsky, PhD Dermatology Vesna Petronic-Rosic, MD Emergency Medicine Linda Druelinger, MD #23 NIH Funding Endocrinology, Diabetes & Metabolism Ronald Cohen, MD Gastroenterology, Hepatology & Nutrition David Rubin, MD General Medicine Deborah Burnet, MD #10 NIH Funding/Faculty Genetic Medicine Yoav Gilad, PhD Geriatrics & Palliative Medicine Stacie Levine, MD * CLINICAL $64M Total NIH Awards Hematology/Oncology Walter Stadler, MD Hospital Medicine David Meltzer, MD, PhD $104M Total Sponsored Infectious Diseases & Global Health David Pitrak, MD ACTIVITY Nephrology Arlene Chapman, MD Research Awards & Pulmonary/Critical Care Gokhan Mutlu, MD Rheumatology Marcus Clark, MD Clinical Trails Earnings Committee Diversity Committee Monica Vela, MD Chairs: Women’s Committee Helen Te, MD Julie Oyler, MD* 13,364 Admissions Chief 2017 Chief Residents: Nikhil Bassi, MD Residents Yasmin Karimi, MD 221,675 Outpatient Visits Cathryn Lee, MD Aaron Tannebaum, MD 329 63,507 Emergency Room Encounters 2018 Chief Residents Amrish Deshmukh, MD TRANSPLANT 1,118,608 RVUs Abdul Dia, MD Michelle Fletcher, MD CASES Erica MacKenzie, MD Senior Budget and Finance Sunila Goel Management: Clinical Revenue and Billing Lisa Kogan Clinical Research Support Allison Buonamici Clinical Trials Financial Group Ashley Hoambrecker Human Resources (Academic) Sharon Frazier Human Resources (Staff) Chris Yaros 302 TRAINEES EDUCATIONAL Information Systems Max Marchevsky Research Administration Katie Pizer *new in FY 18 188 RESIDENTS ACTIVITY 114 SUBSPECIALTY FELLOWS 2 Department of Medicine special awards 2017 Elected Fellows of the Elected Members of the National Academy of Medicine American Academy of Arts and Sciences • Graeme Bell, PhD • Graeme Bell, PhD • Marshall Chin, MD++ • Olufunmilayo Olopade, MD • Robert Gibbons, PhD • David Meltzer, MD, PhD Elected Members of the Association of American Physicians • Olufunmilayo Olopade, MD • Michael A. Becker, MD • Kenneth Polonsky, MD • Eugene Chang, MD • Arlene Chapman, MD American College of Physicians Masters • Marcus Clark, MD • Holly Humphrey, MD • Fredric Coe, MD • Mark Siegler, MD • Alan Leff, MD • Bana Jabri, MD, PhD Department of Medicine Named Professorships department of medicine • James Liao, MD • Graeme Bell, PhD – Kovler Family Distinguished Professor • David Meltzer, MD, PhD • Eugene Chang, MD – Martin Boyer Professor • Olufunmilayo Olopade, MD • Marshall Chin, MD – Richard Parillo Family Professor in Healthcare Ethics awards • Kenneth Polonsky, MD • Thomas Gajewski, MD, PhD – Abbvie Foundation Professor ++ • Mark J. Ratain, MD • Robert Gibbons, PhD – Blum Riese Professor+ • Samuel Refetoff, MD • Harvey Golomb, MD – Lowell T. Coggeshall Professor Distinguished Service Awards Leif B. Sorensen, MD, Biological Sciences Division Awards • Angelo Scanu, MD • Robert Grossman, PhD – Frederick H. Rawson Professor+ • Joseph B. Kirsner, MD, PhD (2006) PhD Faculty Research Award • Distinguished Educator/Mentor – • Mark Siegler, MD • Holly Humphrey, MD – Ralph W Gerard Professor • Janet Rowley, MD (2007) • Suzanne Conzen, MD ( 2007) • Dorothy Hanck, PhD • Julian Solway, MD • James Liao, MD, PhD – Harold H. Hines, Jr. Professor • Louis Cohen, MD (2008) • Marisa Alegre, MD, PhD (2008) • Distinguished Clinicians: • Everett Vokes, MD • Michelle Le Beau, PhD – Arthur and Marian Edelstein Professor • Morton Arnsdorf, MD (2009) • Anne Sperling, MD (2008) • Senior Awards – • David Meltzer, MD, PhD – Fanny L. Pritzker Professor • Angelo Scanu, MD (2010) • Bana Jabri, MD, PhD (2009) Edward