The Impact of Chromosomal Translocation Locus and Fusion Oncogene Coding Sequence in Synovial Sarcomagenesis
HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Oncogene Manuscript Author . Author manuscript; Manuscript Author available in PMC 2016 September 23. Published in final edited form as: Oncogene. 2016 September 22; 35(38): 5021–5032. doi:10.1038/onc.2016.38. The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis Kevin B. Jones1,2,3,*, Jared J. Barrott1,2,3, Mingchao Xie4, Malay Haldar5, Huifeng Jin1,2,3, Ju-Fen Zhu1,2,3, Michael J. Monument1,3, Tim L. Mosbruger3,6, Ellen M. Langer5, R. Lor Randall1,3, Richard K. Wilson4,7,8,9, Bradley R. Cairns2,3,10, Li Ding4,7,8,9, and Mario R. Capecchi5 1Department of Orthopaedics, University of Utah, Salt Lake City, Utah 84112, USA 2Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA 3Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA 4Department of Medicine, Washington University, St. Louis, Missouri 63108, USA 5Department of Human Genetics, University of Utah, Salt Lake City, Utah, USA 6Deparment of Bioinformatics, University of Utah, Salt Lake City, Utah, 84112, USA 7McDonnell Genome Institute, Washington University, St. Louis, Missouri 63108, USA 8Department of Genetics, Washington University, St. Louis, Missouri 63108, USA 9Siteman Cancer Center, Washington University, St. Louis, Missouri 63108, USA 10Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA Abstract Synovial sarcomas are aggressive soft-tissue malignancies that express chromosomal translocation-generated fusion genes, SS18-SSX1 or SS18-SSX2 in most cases. Here, we report a mouse sarcoma model expressing SS18-SSX1, complementing our prior model expressing SS18- SSX2.
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