Identification of Unknown Residues
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Nitrate Prodrugs Able to Release Nitric Oxide in a Controlled and Selective
Europäisches Patentamt *EP001336602A1* (19) European Patent Office Office européen des brevets (11) EP 1 336 602 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.7: C07C 205/00, A61K 31/00 20.08.2003 Bulletin 2003/34 (21) Application number: 02425075.5 (22) Date of filing: 13.02.2002 (84) Designated Contracting States: (71) Applicant: Scaramuzzino, Giovanni AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU 20052 Monza (Milano) (IT) MC NL PT SE TR Designated Extension States: (72) Inventor: Scaramuzzino, Giovanni AL LT LV MK RO SI 20052 Monza (Milano) (IT) (54) Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases (57) New pharmaceutical compounds of general effects and for this reason they are useful for the prep- formula (I): F-(X)q where q is an integer from 1 to 5, pref- aration of medicines for prevention and treatment of in- erably 1; -F is chosen among drugs described in the text, flammatory, ischemic, degenerative and proliferative -X is chosen among 4 groups -M, -T, -V and -Y as de- diseases of musculoskeletal, tegumental, respiratory, scribed in the text. gastrointestinal, genito-urinary and central nervous sys- The compounds of general formula (I) are nitrate tems. prodrugs which can release nitric oxide in vivo in a con- trolled and selective way and without hypotensive side EP 1 336 602 A1 Printed by Jouve, 75001 PARIS (FR) EP 1 336 602 A1 Description [0001] The present invention relates to new nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without the side effects typical of nitrate vasodilators drugs. -
(12) United States Patent (10) Patent No.: US 6,927,224 B2 Kaltenbach Et Al
USOO6927224B2 (12) United States Patent (10) Patent No.: US 6,927,224 B2 Kaltenbach et al. (45) Date of Patent: Aug. 9, 2005 (54) SELECTIVE ESTROGEN RECEPTOR Evans, R.M., “The Steroid and Thyroid Hormone Receptor MODULATORS Superfamily”, Science, vol. 240, pp. 889-895 (1988). Jordan, V.C. et al., “Endocrine Pharmacology of Antiestro (75) Inventors: Robert F. Kaltenbach, Wilmington, DE gens as Antitumor Agents', Endocrine Reviews, Vol. 11, No. (US); Simon P. Robinson, Stow, MA 4, pp. 578-610 (1990). (US); George L. Trainor, Wilmington, Kedar, R.P. et al., “Effects of tamoxifen on uterus and DE (US) ovaries of postmenopausal women in a randomised breast cancer prevention trial”, Lancet, vol. 343, pp. 1318-1321 (73) Assignee: Bristol Myers Squibb Company, (1994). Princeton, NJ (US) Love, R.R. et al., “Effects of Tamoxifen on Bone Mineral (*) Notice: Subject to any disclaimer, the term of this Density in Postmenopausal Women with Breast Cancer', patent is extended or adjusted under 35 The New England Journal of Medicine, vol. 326, No. 13, pp. U.S.C. 154(b) by 0 days. 852-856 (1992). Love, R.R. et al., “Effects of Tamoxifen on Cardiovascular Risk Factors in Postmenopausal Women', Annals of Internal (21) Appl. No.: 10/216,253 Medicine, vol. 115, pp. 860-864 (1991). (22) Filed: Aug. 9, 2002 McCague, R. et al., “Synthesis and Estrogen Receptor Binding of 6,7-Dihydro-8-phenyl-9-4-2-(dimethylami (65) Prior Publication Data no)ethoxyphenyl-5H-benzocycloheptene, a Nonisomeriz US 2003/0105148 A1 Jun. 5, 2003 able Analogue of Tamoxifen. X-ray Crystallographic Stud ies”, J. -
The Use of Capillary Electrophoresis (CE) in Drug Analysis
Florida International University FIU Digital Commons FIU Electronic Theses and Dissertations University Graduate School 3-28-2005 The use of capillary electrophoresis (CE) in drug analysis Agnes D. Garcia Follow this and additional works at: https://digitalcommons.fiu.edu/etd Part of the Other Life Sciences Commons Recommended Citation Garcia, Agnes D., "The use of capillary electrophoresis (CE) in drug analysis" (2005). FIU Electronic Theses and Dissertations. 3928. https://digitalcommons.fiu.edu/etd/3928 This work is brought to you for free and open access by the University Graduate School at FIU Digital Commons. It has been accepted for inclusion in FIU Electronic Theses and Dissertations by an authorized administrator of FIU Digital Commons. For more information, please contact [email protected]. FLORIDA INTERNATIONAL UNIVERSITY Miami, Florida THE USE OF CAPILLARY ELECTROPHORESIS (CE) IN DRUG ANALYSIS A thesis submitted in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE in FORENSIC SCIENCE by Agnes D. Garcia 2005 To: Dean R. Bruce Dunlap College of Arts and Sciences This thesis, written by Agnes D. Garcia, and entitled The Use of Capillary Electrophoresis (CE) in Drug Analysis, having been approved in respect to style and intellectual content, is referred to you for judgment. We have read this thesis and recommend that it be approved. Kenneth Furton Bruce McCord Jose R. Almirall, Major Professor Date of Defense: March 28,2005 The thesis of Agnes D. Garcia is approved. Dean R. Bruce Dunlap College of Arts and Sciences Dean Douglas Wartzok University Graduate School Florida International University, 2005 ii © Copyright 2005 by Agnes D. -
Schwangerschaften Während Der Anwendung Kontrazeptiver Methoden
Journal für Reproduktionsmedizin und Endokrinologie – Journal of Reproductive Medicine and Endocrinology – Andrologie • Embryologie & Biologie • Endokrinologie • Ethik & Recht • Genetik Gynäkologie • Kontrazeption • Psychosomatik • Reproduktionsmedizin • Urologie Schwangerschaften während der Anwendung kontrazeptiver Methoden - Eine Stellungnahme der Deutschen Gesellschaft für Gynäkologische Endokrinologie und Fortpflanzungsmedizin (DGGEF) e.V. und des Berufsverbands der Frauenärzte (BVF) e.V. Rabe T, Goeckenjan M, Dikow N, Schaefer C, Ahrendt HJ Mueck AO, Merkle E, Merki G, Egarter C, König K Albring C J. Reproduktionsmed. Endokrinol 2013; 10 (4), 214-234 www.kup.at/repromedizin Online-Datenbank mit Autoren- und Stichwortsuche Offizielles Organ: AGRBM, BRZ, DVR, DGA, DGGEF, DGRM, D·I·R, EFA, OEGRM, SRBM/DGE Indexed in EMBASE/Excerpta Medica/Scopus Krause & Pachernegg GmbH, Verlag für Medizin und Wirtschaft, A-3003 Gablitz FERRING-Symposium digitaler DVR 2021 Mission possible – personalisierte Medizin in der Reproduktionsmedizin Was kann die personalisierte Kinderwunschbehandlung in der Praxis leisten? Freuen Sie sich auf eine spannende Diskussion auf Basis aktueller Studiendaten. SAVE THE DATE 02.10.2021 Programm 12.30 – 13.20Uhr Chair: Prof. Dr. med. univ. Georg Griesinger, M.Sc. 12:30 Begrüßung Prof. Dr. med. univ. Georg Griesinger, M.Sc. & Dr. Thomas Leiers 12:35 Sind Sie bereit für die nächste Generation rFSH? Im Gespräch Prof. Dr. med. univ. Georg Griesinger, Dr. med. David S. Sauer, Dr. med. Annette Bachmann 13:05 Die smarte Erfolgsformel: Value Based Healthcare Bianca Koens 13:15 Verleihung Frederik Paulsen Preis 2021 Wir freuen uns auf Sie! Schwangerschaften während der Anwendung kontrazeptiver Methoden Schwangerschaften während der Anwendung kontrazeptiver Methoden* Eine Stellungnahme der Deutschen Gesellschaft für Gynäkologische Endokrinologie und Fortpflanzungsmedizin (DGGEF) e.V. -
U.S. Medical Eligibility Criteria for Contraceptive Use, 2010
Morbidity and Mortality Weekly Report www.cdc.gov/mmwr Early Release May 28, 2010 / Vol. 59 U.S. Medical Eligibility Criteria for Contraceptive Use, 2010 Adapted from the World Health Organization Medical Eligibility Criteria for Contraceptive Use, 4th edition department of health and human services Centers for Disease Control and Prevention Early Release CONTENTS The MMWR series of publications is published by the Office of Surveillance, Epidemiology, and Laboratory Services, Centers for Introduction .............................................................................. 1 Disease Control and Prevention (CDC), U.S. Department of Health Methods ................................................................................... 2 and Human Services, Atlanta, GA 30333. How to Use This Document ......................................................... 3 Suggested Citation: Centers for Disease Control and Prevention. [Title]. MMWR Early Release 2010;59[Date]:[inclusive page numbers]. Using the Categories in Practice ............................................... 3 Recommendations for Use of Contraceptive Methods ................. 4 Centers for Disease Control and Prevention Contraceptive Method Choice .................................................. 4 Thomas R. Frieden, MD, MPH Director Contraceptive Method Effectiveness .......................................... 4 Peter A. Briss, MD, MPH Unintended Pregnancy and Increased Health Risk ..................... 4 Acting Associate Director for Science Keeping Guidance Up to Date ................................................... -
Part I Biopharmaceuticals
1 Part I Biopharmaceuticals Translational Medicine: Molecular Pharmacology and Drug Discovery First Edition. Edited by Robert A. Meyers. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2018 by Wiley-VCH Verlag GmbH & Co. KGaA. 3 1 Analogs and Antagonists of Male Sex Hormones Robert W. Brueggemeier The Ohio State University, Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Columbus, Ohio 43210, USA 1Introduction6 2 Historical 6 3 Endogenous Male Sex Hormones 7 3.1 Occurrence and Physiological Roles 7 3.2 Biosynthesis 8 3.3 Absorption and Distribution 12 3.4 Metabolism 13 3.4.1 Reductive Metabolism 14 3.4.2 Oxidative Metabolism 17 3.5 Mechanism of Action 19 4 Synthetic Androgens 24 4.1 Current Drugs on the Market 24 4.2 Therapeutic Uses and Bioassays 25 4.3 Structure–Activity Relationships for Steroidal Androgens 26 4.3.1 Early Modifications 26 4.3.2 Methylated Derivatives 26 4.3.3 Ester Derivatives 27 4.3.4 Halo Derivatives 27 4.3.5 Other Androgen Derivatives 28 4.3.6 Summary of Structure–Activity Relationships of Steroidal Androgens 28 4.4 Nonsteroidal Androgens, Selective Androgen Receptor Modulators (SARMs) 30 4.5 Absorption, Distribution, and Metabolism 31 4.6 Toxicities 32 Translational Medicine: Molecular Pharmacology and Drug Discovery First Edition. Edited by Robert A. Meyers. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2018 by Wiley-VCH Verlag GmbH & Co. KGaA. 4 Analogs and Antagonists of Male Sex Hormones 5 Anabolic Agents 32 5.1 Current Drugs on the Market 32 5.2 Therapeutic Uses and Bioassays -
In Vitro Estrogenic Actions in Rat and Human Cells of Hydroxylated Derivatives of D16726 (Zindoxifene), an Agent with Known Antimammary Cancer Activity in Vivo1
[CANCER RESEARCH 48, 784-787, February 15, 1988] In Vitro Estrogenic Actions in Rat and Human Cells of Hydroxylated Derivatives of D16726 (Zindoxifene), an Agent with Known Antimammary Cancer Activity in Vivo1 S. P. Robinson, R. Koch, and V. C. Jordan2 Department of Human Oncology, University of Wisconsin Clinical Cancer Center, Madison, Wl 53792 ABSTRACT derivative D15414, (compound I, Fig. 1) in vitro (17, 19). This is of particular interest if the tumor inhibitory activity of A series of 2-phenyl-l-ethyl-3-methylindoles with or without a hy- D16726 is by estrogen antagonism as this compound does not droxyl group in the para position of the phenyl ring and the 5 or 6 position of the indole nucleus were compared with 17/3-estradiol in the have a structural equivalent of the alkylaminoethoxy side chain. We now report the activity of a series of 2-phenylindole stimulation of (a) prolactin production in rat pituitary cells in primary culture, (b) progesterone receptor synthesis in MCF-7 cells, and (c) derivatives, including D15414, in the stimulation of prolactin proliferation of MCF-7 cells. All compounds were less active than production in rat pituitary cells in primary culture and the i-stradini but all derivatives including 1)15414, the hydroxylated metab stimulation of progesterone receptor synthesis and growth of olite of D16726 (zindoxifene, a known antitumor agent against mammary MCF-7 cells. cancer) were fully estrogenic. Hydroxyl groups at the para position of the phenyl ring and 6 position of the indole nucleus conferred the highest estrogen potency [ED»(drug MATERIALS AND METHODS concentration producing 50% of maximum activity) in all assays around 10 "' M|. -
Progesterone 7K77 49-3265/R3 B7K770 Read Highlighted Changes Revised April, 2010 Progesterone
en system Progesterone 7K77 49-3265/R3 B7K770 Read Highlighted Changes Revised April, 2010 Progesterone Customer Service: Contact your local representative or find country specific contact information on www.abbottdiagnostics.com Package insert instructions must be carefully followed. Reliability of assay results cannot be guaranteed if there are any deviations from the instructions in this package insert. Key to symbols used List Number Calibrator (1,2) In Vitro Diagnostic Medical Control Low, Medium, High Device (L, M, H) Lot Number Reagent Lot Expiration Date Reaction Vessels Serial Number Sample Cups Septum Store at 2-8°C Replacement Caps Consult instructions for use Warning: May cause an allergic reaction Contains sodium azide. Contact Manufacturer with acids liberates very toxic gas. See REAGENTS section for a full explanation of symbols used in reagent component naming. 1 NAME REAGENTS ARCHITECT Progesterone Reagent Kit, 100 Tests INTENDED USE NOTE: Some kit sizes are not available in all countries or for use on all ARCHITECT i Systems. Please contact your local distributor. The ARCHITECT Progesterone assay is a Chemiluminescent Microparticle Immunoassay (CMIA) for the quantitative determination of progesterone in ARCHITECT Progesterone Reagent Kit (7K77) human serum and plasma. • 1 or 4 Bottle(s) (6.6 mL) Anti-fluorescein (mouse, monoclonal) fluorescein progesterone complex coated Microparticles SUMMARY AND EXPLANATION OF TEST in TRIS buffer with protein (bovine and murine) and surfactant Progesterone is produced primarily by the corpus luteum of the ovary stabilizers. Concentration: 0.1% solids. Preservatives: sodium azide in normally menstruating women and to a lesser extent by the adrenal and ProClin. cortex.1 At approximately the 6th week of pregnancy, the placenta 2-5 • 1 or 4 Bottle(s) (17.0 mL) Anti-progesterone (sheep, becomes the major producer of progesterone. -
Steroids – Basic Science
STEROIDS – BASIC SCIENCE Edited by Hassan Abduljabbar Steroids – Basic Science Edited by Hassan Abduljabbar Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2011 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Bojan Rafaj Technical Editor Teodora Smiljanic Cover Designer InTech Design Team Image Copyright loriklaszlo, 2011. DepositPhotos First published December, 2011 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from [email protected] Steroids – Basic Science, Edited by Hassan Abduljabbar p. -
有限公司 Testosterones
® 伊域化學藥業(香港)有限公司 YICK-VIC CHEMICALS & PHARMACEUTICALS (HK) LTD Rm 1006, 10/F, Hewlett Centre, Tel: (852) 25412772 (4 lines) No. 52-54, Hoi Yuen Road, Fax: (852) 25423444 / 25420530 / 21912858 Kwun Tong, E-mail: [email protected] YICK -VIC 伊域 Kowloon, Hong Kong. Site: http://www.yickvic.com Testosterones Product Code CAS Product Name MIS-42658 1043-10-3 (8S,9S,10R,11S,13S,14S,17S)-11,17-DIHYDROXY-10,13,17-TRIMETHYL-2,6,7,8,9,11,12,14,15,16-DECAHYDRO-1H-CYCLOPENTA[A]PHENA NTHREN-3-ONE UNIE-13864 564-35-2 11-KETOTESTOSTERONE PH-1081U 17-ALPHA-HYDROXYTESTOSTERONE ACETATE MIS-39218 51154-09-7 17ALPHA-METHYLTESTOSTERONE 4,5-EPOXIDE PH-1121 72-63-9 17BETA-HYDROXY-17-METHYLANDROSTA-1,4-DIEN-3-ONE MIS-34565 5585-85-3 17BETA-HYDROXY-17-METHYLANDROSTA-4,6-DIEN-3-ONE PH-1081S 17BETA-HYDROXYANDROST-1-ENE-3-ONE TETRAHYDROPYRANYL ETHER PH-1081VA 1-TESTOSTERONE ETHYL CARBONATE PH-1081VB 1-TESTOSTERONE METHYL CARBONATE PH-1081VC 1-TESTOSTERONE PROPYL CARBONATE PH-1081HB 1-TESTOSTERONE UNDECANOATE UNIE-15172 2141-17-5 4-HYDROXYTESTOSTERONE UNIE-13597 62-99-7 6BETA-HYDROXYTESTOSTERONE SPI-4361 14531-84-1 6-DEHYDRO-19-NORTESTOSTERONE PH-1081PK 1057-07-4 ANDROSTANOLONE 17-BENZOATE Copyright © 2018 YICK-VIC CHEMICALS & PHARMACEUTICALS (HK) LTD. All rights reserved. Page 1 of 3 Product Code CAS Product Name PH-1133 1605-89-6 BOLASTERONE UNIE-8525 CHLORDEHYDROMETHYLTESTOSTERONE PH-1081JA 1093-58-9 CLOSTEBOL PH-1081JB 855-19-6 CLOSTEBOL ACETATE SPI-0027GA 481-30-1 EPITESTOSTERONE SPI-0027GB EPITESTOSTERONE ACETATE PH-1081K 434-03-7 ETHISTERONE PH-1136B 76-43-7 -
Testosterone Art. 31
Annex I List of the names, pharmaceutical forms, strengths of the medicinal products, routes of administration, and marketing authorisation holders in the Member States 1 Member Marketing authorisation INN Invented name Strength Pharmaceutical Route of State holder form administration (in EEA) Austria Bayer Austria GmbH testosterone undecanoat Nebido 1000 mg/4 ml 1000 mg/4ml solution for intramuscular use Herbststrasse 6-10 Injektionslösung injection 1160 Wien Austria Austria Eli Lilly GmbH testosterone Axiron 30 mg/1,5 ml 30 mg/1,5ml gel cutaneous use Kölblgasse 8-10 Lösung zur 1030 Wien Anwendung auf der Austria Haut Austria Laboratoires Besins testosterone Testogel 25 mg - Gel 25 mg gel cutaneous use International SA im Beutel Rue de Bourg lÀbbè 3 75003 Paris France Austria Laboratoires Besins testosterone Testogel 50 mg - Gel 50 mg gel cutaneous use International SA im Beutel Rue de Bourg lÀbbè 3 75003 Paris France Austria ProStrakan Ltd. testosterone Tostran 2% - Gel 0.02 gel cutaneous use Galabank Business Park TD1 1QH Galashiels United Kingdom Austria Laboratoires Besins testosterone Androgel 25 mg - Gel 25 mg gel cutaneous use International SA im Beutel Rue de Bourg lÀbbè 3 75003 Paris France Austria Laboratoires Besins testosterone Androgel 50 mg - Gel 50 mg gel cutaneous use International SA im Beutel Rue de Bourg lÀbbè 3 75003 Paris France Austria N.V. Organon testosterone undecanoat Andriol Testocaps 40 40 mg capsule, soft oral use Kloosterstraat 6 mg - Kapseln 5349 AB Oss The Netherlands 2 Member Marketing authorisation INN Invented name Strength Pharmaceutical Route of State holder form administration (in EEA) Belgium Besins Healthcare testosterone Androgel 25 mg gel transdermal use Avenue Louise 287 1050 Brussels Belgium Belgium Besins Healthcare testosterone Androgel 50 mg gel transdermal use Avenue Louise 287 1050 Brussels Belgium Belgium Eli Lilly Benelux S.A.-N.V. -
Endocrine Dynamic Function Protocols
South Eastern Area Laboratory Services DEPARTMENT OF CLINICAL CHEMISTRY & ENDOCRINOLOGY SEALS Pathology Service Randwick Campus Dynamic Function Protocol DETAILS OF TESTS AVAILABLE AND SPECIMENS REQUIRED Compiled by: Phoebe Stanford Registrar Dept of Clinical Chemistry and Endocrinology SEALS North South Eastern Area Laboratory Services SEALS PATHOLOGY SERVICE RANDWICK CAMPUS TABLE OF CONTENTS PATIENT PREPARATION……………………………………………………….. 4 PROCEDURE FOR USING THE GLUCOMETER…………………………….. 6 PANCREAS DIABETES GLUCOSE TOLERANCE TEST …………………………………………………………………………..7 GESTATIONAL DIABETES SCREENING………………………………………………………………..8 GTT FOR INSULIN RESISTANCE (PCOS)…………………………………………………………….10 MEAL TOLERANCE……………………………………………………………………………………….10 EXTENDED GLUCOSE TOLERANCE TEST……………………………………………………11 ANTERIOR PITUITARY ANTERIOR PITUITARY FUNCTION ITT………………………………………………………………………………………………..12 CUSHING'S DISEASE OVERNIGHT DEXAMETHASONE TEST……………………………………………………15 BILATERAL SIMULTANEOUS INFERIOR PETROSAL SINUS SAMPLING…………….16 ACROMEGALY GROWTH HORMONE SUPPRESSION TEST (OGTT) FOR ACROMEGALY……………26 POSTERIOR PITUITARY DIABETES INSIPIDUS WATER DEPRIVATION TEST………………………………………………………………..27 ADRENAL ADRENAL INSUFFICIENCY SHORT SYNACTHEN TEST…………………………………………………………………..30 SYNACTHEN TEST - CONGENITAL ADRENAL HYERPLASIA………………………….32 HYPERALDOSTERONISM SALINE SUPPRESSION TEST………………………………………………………………..33 LYING/STANDING AND FRUSEMIDE TEST………………………………………………..34 ADRENAL VENOUS SAMPLING……………………………………………………………..36 CHEMAI - Dynamic Function Protocol - 05 Page 2 of 47 Authorised by: