Anterior Interosseous Nerve Palsy: Spontaneous Recovery in Two Patients
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J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.37.10.1146 on 1 October 1974. Downloaded from Journal of Neurology, Neurosurgery, and Psychiatry, 1974, 37, 1146-1150 Anterior interosseous nerve palsy: spontaneous recovery in two patients CHRISTOPHER GARDNER-THORPE' From the Regional Neurological Centre, Newcastle General Hospital, Newcastle upon Tyne SYNOPSIS The case histories of two patients who developed an anterior interosseous nerve palsy apparently as a result of an external pressure injury are reported. Both patients recovered fully without surgical exploration, one 19 months and the other nine months after the onset. It is stressed that complete recovery may occur spontaneously. interosseous fingers, together with weakness of pronation Palsy due to lesions of the anterior guest. Protected by copyright. nerve is rare. Most of the literature on the sub- when the elbow is flexed (in order to minimize ject stems from orthopaedic sources: in particu- pronation due to the action of pronator teres lar, the work of Spinner (1972) is noteworthy. which is not weak). Sensory testing is normal as However, anterior interosseous nerve palsy may is power in the other muscles supplied by the present to the neurologist as well as to the ortho- median nerve-for example, abductor pollicis paedic surgeon. The purpose of this paper is to brevis. The characteristic clinical picture, there- report the case histories of two patients who fore, is weakness of pinch together with developed it probably as a result of external inability actively to flex the interphalangeal pressure and to draw attention to the spon- joint of the thumb and the terminal inter- taneous recovery which may occur and which phalangeal joint of the index finger. These joints renders surgical exploration unnecessary. become hyperextended and the proximal inter- phalangeal joints flexed. The index finger con- USUAL ANATOMICAL FINDINGS (Davies and Coup- tacts the pulp of the thumb at a point situated land, 1967) The anterior interosseous nerve more proximally than is normal. In some arises from the median nerve where the latter patients, pain and tenderness may be found in passes between the two heads of the pronator the proximal part of the forearm. teres just below the elbow. The anterior inter- osseous nerve passes down the forearm and Anatomical anomalies Anomalies in the dis- http://jnnp.bmj.com/ supplies three muscles-flexor pollicis longus, tribution of the anterior interosseous nerve are flexor digitorum profundus to the index and not uncommon (Wilson, 1954). The Martin- middle fingers, and pronator quadratus. Sensory Gruber anastomosis (Martin, 1763; Gruber, fibres in the nerve arise from end-organs in the 1870) is a communication between the motor distal radio-ulnar joint and the wrist joint. The fibres of the median nerve or its branches and the anterior interosseous nerve does not convey ulnar nerve in the forearm which occurs in 15% fibres from in the skin and it of limbs (Thompson, 1893). Approximately one sensory end-organs on September 24, 2021 by may be regarded as a pure motor nerve for Martin-Gruber anastomosis in two arises from practical clinical purposes. the anterior interosseous nerve and therefore a Palsy of the anterior interosseous nerve is lesion of that nerve can sometimes cause weak- characterized by weakness of flexion of the inter- ness of the ulnar-innervated small muscles of the phalangeal joint of the thumb and terminal hand (Mannerfelt, 1966). The part of the flexor interphalangeal joints of the index and middle digitorum profundus muscle which controls the index finger is usually supplied by the anterior 1 Present address: Department of Neurology, Royal Devon and Exeter Hospital (Wonford), Barrack Road, Exeter EX2 5DW. interosseous nerve (Sunderland, 1945) but the 1146 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.37.10.1146 on 1 October 1974. Downloaded from Anzterior interosseous nerve palsy: spontaneous recovery in two patienits 1147 part which controls the middle finger may be the medial root of the median nerve. The prona- supplied by the median nerve, the ulnar nerve, tor syndrome (Seyffarth, 1951) may easily be or both. Flexor pollicis longus may also receive distinguished, since the main trunk of the median a branch directly from the median nerve but it nerve is compromised. O'Brien and Upton (1972) seems that pronator quadratus is always sup- were the first to describe the detailed clinical plied by the anterior interosseous nerve (Sunder- neurophysiological investigation of a patient land, 1968). with anterior interosseous nerve palsy. CAUSES OF PALSY OF ANTERIOR INTEROSSEOUS Prognosis and treatment Many of the patients NERVE These may be summarized as follows: discussed in the early case reports did not receive any specific treatment. Recovery was 1. Injury slow and the pathology not always known. Of a. Penetrating injuries Knife wounds, bullet the 36 patients with neuralgic amyotrophy dis- wounds, and forearm venous injections. In one cussed by Parsonage and Turner (1948) six had case, the palsy appeared 10 years after a stab isolated weakness of flexor pollicis longus and wound (Spinner, 1972). flexor digitorum profundus: one patient re- b. Supracondylar fracture of humerus in covered in a few months but the prognosis in the children Probably due to traction on the other five is not known. Partial recovery anterior interosseous nerve (Spinner and Schrei- occurred after 12 and 23 months in the two ber, 1969) rather than to pressure on the patients reported by Kiloh and Nevin (1952) and guest. Protected by copyright. posterior fibres of the median nerve (Lipscomb the two patients described by Thomas (1962) and Burleson, 1955). recovered almost completely. Return of function c. Midshaft fracture of radius (Spinner, 1972). started four to six weeks after a closed fracture d. Operative procedure for the relief of flexion of the forearm in the two patients described by contracture in the forearm (Page, 1923). Warren (1963) and power was normal after five and seven months. Partial recovery occurred 2. Muscle abnormality after six and 18 months in the patients reported a. Tendinous origin of the deep head ofpronator by Farber and Bryan (1968): one patient had teres, flexor digitorum profundus or palmaris worn a plaster cast for recurrent dislocation of longus (Spinner, 1972). the humerus before the anterior interosseous b. Accessory head of flexor pollicis longus- palsy developed. Gantzer's (1813) muscle-or accessory muscle The first description of an operation for this and tendon between flexor digitorum super- palsy has been attributed to Fearn and Good- ficialis and flexor pollicis longus. fellow (1965) who divided a fibrous band and 3. Vascular abnormality showed complete recovery after three months. a. Scarring and swelling of muscle in Volkmann's However, Lipscomb and Burleson (1955) de- ischaemia (Lipscomb and Burleson, 1955). scribed the operations performed in four patients http://jnnp.bmj.com/ b. Aberrant radial artery. with a supracondylar fracture of the humerus c. Thrombosis of ulnar collateral vessels. primarily to relieve brachial artery compression but the outcome, so far as the anterior inter- 4. Neuralgic amyotrophy osseous nerve was concerned, was the same- Usually with evidence of involvement of other complete recovery of function. Fibrous bands roots or nerves (Parsonage and Turner, 1948). have been divided by other workers (Stern et al., Mills et 1967; Sharrard, 1968, al., 1969; Schmidt on September 24, 2021 by 5. Enlarged bicipital bursa and Eiken, 1971) and recovery has followed after DIFFERENTIAL DIAGNOSIS Other conditions may periods ranging from 10 days to four months. mimic anterior interosseous palsy. The more Spinner (1970, 1972) and Spinner and important of these include congenital absence of Schreiber (1969) advocated exploration immedi- the deep flexor muscles (Spinner, 1972), rupture ately after penetrating wounds and after an of the flexor tendons in rheumatoid disease and interval of six to eight weeks in other cases when Kienbock's disease (James, 1949), and lesions of there had not been any clinical or electromyo- J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.37.10.1146 on 1 October 1974. Downloaded from 1148 Christopher Gardner-Thorpe graphic evidence of recovery. Spinner also Case I Positive sharp wave potentials were pointed out that nerve and tendon transplant recorded from pronator quadratus where motor unit operations may help to normalize the function potentials were of reduced amplitude in contrast to of the limb. the normal potentials recorded from abductor pollicis brevis and flexor pollicis longus. The inter- ference pattern on maximum voluntary activity was CASE 1 reduced both in density and amplitude in pronator M.B. (N46796), a 35 year old housewife, first quadratus and flexor pollicis longus: it was normal noticed pain in the left cubital fossa in February in abductor pollicis brevis. 1972. At about that time she had frequently been lifting her baby's carrycot into and out of the car, Case 2 Fibrillation potentials were recorded from through the driver's door (right hand drive) and on pronator quadratus. The interference pattern was to the back seat, but she does not recall whether she reduced in flexor digitorum profundus and pronator held the carrycot straps over her forearm. A few quadratus but the remainder of the examination, days after the appearance of the pain, which was including the abductor pollicis brevis, was normal. accentuated by extension of the elbow, she noticed difficulty in moving the distal joints of the thumb and MOTOR NERVE CONDUCTION Motor nerves were index finger although sensation in the hand and digits stimulated with saline-soaked pads placed on the was quite normal. Typewriting, sewing, knitting, skin overlying the nerves. The responses were re- filing the nails, turning a key, lifting coins from a corded from concentric needle electrodes placed in purse, and fastening buttons were particularly diffi- the appropriate muscles.