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CSIR Technologies for COVID-19 Mitigation

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CSIR Technologies for COVID-19 Mitigation Fold CYANMAGENTAYELLOWBLACK CSIR Technologies for COVID-19 Mitigation Council of Scientific and Industrial Research Fold iv CSIR Technologies for COVID-19 Mitigation Council of Scientific and Industrial Research RAFI MARG, NEW DELHI – 110 001 i CSIR Technologies for COVID-19 Mitigation July 2020 Formatting & Designing Neeru Vijan, Sarla Dutta and Abhinav Raj Production Neelu Srivastav and Ashwani Brahmi Designed and Printed by CSIR-National Institute of Science Communication and Information Resources (CSIR-NISCAIR) Vigyan Sanchar Bhawan, New Delhi ii Foreword he COVID-19 pandemic has brought the world literally to a Tstandstill. There is still no cure or a vaccine for this highly infectious disease. The WHO declared COVID-19 as a pandemic on 11 March 2020 and ever since, scientists all over the world have been in pursuit of a cure or a vaccine and have been developing technologies to combat this pandemic. CSIR, through its 38 laboratories and expertise in diverse areas ranging from aerospace to buildings to genomics to chemicals, quickly sprang into action developing COVID-19 interventions. For effective planning and strategizing, CSIR swiftly set up five COVID-19 verticals including disease surveillance, drugs & vaccines, testing & diagnostics, PPEs and supply chain management. CSIR's rich R&D knowledgebase is embodied in the rapid testing, cost-effective diagnostic kits, virus culture, genome sequencing and disease surveillance. With the perfect blend of scientific knowledge, technical expertise, industry linkages and governmental interfaces, in about 100 days CSIR has come up with almost as many technologies and products to be deployed against COVID-19. From innovations and improvisations, these technologies have different levels of sophistication. Right from ventilators to indigenous diagnostic kits to clinical trials of repurposed drugs to much needed WHO stipulated hand sanitizers and masks, CSIR has been at the forefront in the nation's crusade against COVID-19. CSIR has developed direct RT-PCR method and novel FELUDA diagnostic kit for COVID-19. When the country faced a shortage of PPEs, CSIR developed a protective coverall and today coveralls are being manufactured in the thousands. CSIR developed a ventilator in a record 36 days. Even the mundane but must-adorn mask underwent various kinds of innovations in terms of the materials woven or the coatings layered in them. About 60 out of the 100 or so technologies listed in this compendium have already been transferred to industry partners. The COVID-19 technologies are licensed on a non-exclusive basis and it is heart-warming that all our industrial partners have been quick to respond and engage with us in the larger interest of taking these technologies to the needy in a short time. With the lockdown effecting reverse migration, CSIR took upon itself to provide tons of nutritious and immunity-boosting foods. The recently launched KisanSabha portal and App supports the farmers to get better prices for their produce. It is very heartening that the farming community has received the App very well. We hope that this compendium will not just give an insight into the COVID-19 technologies developed by CSIR so far, but will also spur more innovations. An 'Aatma Nirbhar Bharat' is high on our agenda, and we are eager to partner with more industries to take these technologies to the users. Your feedback and ideas are very welcome. Shekhar C Mande Director General Council of Scientific and Industrial Research iii iv Introduction The ongoing pandemic of Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2). The World Health Organization (WHO) declared the outbreak to be a Public Health Emergency of International Concern on 30th January 2020 and recognized it as a pandemic on 11 March 2020. As of 1 July 2020, there are 5,86,956 cases of COVID-19 in India. Developing technological solutions that are needed to tackle this unprecedented challenge requires strong and cutting edge R&D capability and capacity in diverse disciplines ranging from biological sciences (vaccines, diagnostics, sequencing, testing of drugs) to chemical sciences (drugs: repurposed and new drugs) and engineering (ventilators, PPEs) and interdisciplinary approach transcending barriers. CSIR is uniquely placed as an S&T organization to deliver these at this critical juncture, having proven expertise in sequencing (first human genome sequencing), diagnostics for rare genetic diseases and being the fountain head of generic industry in the country. With expertise ranging from development of aircrafts to advanced materials, CSIR is committed to harness its vast scientific human resource and its considerable capacity and is well poised to serve the diverse needs required immediately and also plan for long term solutions that are needed to control this epidemic. This calls for a strategic, well-coordinated and integrated approach in cooperation with all relevant stakeholders and aligned to government’s strategy. CSIR Strategy to Fight COVID-19 CSIR has advantageously positioned itself to pursue the focused R&D to develop, integrate, scale- up, and deploy necessary technological interventions for combating coronavirus Digital and Molecular Surveillance pandemic in the country. Considering the multifarious problems created by coronavirus which require interventions in several areas and multi-pronged Rapid and Economical Diagnostics strategy, CSIR has set up five technology verticals for addressing the pandemic. These verticals are need-based and New & Repurposed Drugs and span multiple research labs and Vaccines disciplines and draw upon the strength of scientists, students and harness it for the fight against COVID-19. In addition, Hospital Assistive Devices and PPEs CSIR is also working on promoting rural employment and providing ready-to-eat food to the needy migrants. Supply Chain & Logistics CSIR has developed several COVID-19 focused technologies and products ranging from sanitizers & masks to improved tests and diagnostics and ventilators, buildings and structures. The technologies, products and processes listed in the compendium are available for non-exclusive technology transfer. Out of 105 technologies and products in this compendium, 58 have been transferred to various industry partners. For the others, the technologies are in different stages of readiness, the most basic being a working prototype. Interested start-ups and industries may contact the concerned CSIR laboratory for further discussion, and technology transfer. v vi Contents Foreword iii INtrodUctioN v RAPID AND Economical DiagnostICS 3 Dry Swab-based RNA Extraction Free Direct RT-PCR Diagnostics 3 FnCas9 Editor Linked Uniform Detection Assay (FELUDA) 3 IgG/IgM Detection Using a Biolayer Interferometry 4 Micro PCR with Disposable Chip 5 NGS-based High-Throughput Diagnostics 5 One-step RT PCR Kit-COVID-19 6 RT-LAMP Diagnosis of COVID-19 6 Development of REPurposed DRugS/NEw DRugS & Vaccine 9 Coronavirus Culture 9 Process Development of Drugs Repurposed for COVID-19 9 Process for Niclosamide 10 Repurposing of Umifenovir against COVID-19 10 Repurposing of Colchicine for COVID-19 treatment 10 Synthetic Process for Camostat Mesylate 10 Process for Tilorone Dihydrochloride (Interferon Inducer) 11 Zinc Gluconate Vitamin C Formulation (Zincona-C) for Immunity Improvement 11 HospitAL ASSIStIVE DEVICES AND Personal PROtECtIVE EquIPMENt (PPE) 15 Ventilators, Oxygen Concentrators and Other Devices 15 Aerosol Canopy for Dental Procedures 15 Bi level Positive Airway Pressure (BiPAP) System Portable Ventilator 15 Hospital Care Assistive Robotic Device (HCARD) 16 Intubation Hood 16 Oxygen Enrichment Unit (OEU) based on Membrane Technology For Oxygen Therapy 17 Pressure Sensor 17 Respiration Assistance Intervention Device- A Portable Ventilator (Respi-AID) 18 vii Personal Protective Equipment 18 Coverall Suit 18 Efficient Antimicrobial Materials, Formulations and Coatings, Cotton Fabrics for Reusable PPE (Masks/Gowns) 19 Masks and Shields 20 3-D Printed Face Shield 20 3-D Printed Face Mask 20 Face Shield 20 High Efficiency Hydrophobic Three-Layered Facemask 21 Membrane Based Face Mask 21 Printable Face Shield to Protect from COVID-19 21 PolyTi: A Biopolymer Coated Medical Grade Mask 22 Reusable Face Mask with Antimicrobial Coating 23 Reusable Stopgap Face Mask 23 Makeshift Hospitals 24 Karuna Bhawan (Makeshift Hospital for COVID-19) 24 Prefab Foldable Modular Structure for Makeshift Transit Hospital for COVID-19: Poli-Tal(M) 24 Temporary and Short-Term Hospital Structures for Rapid Construction 25 Waste Disposals 25 Flocculant based Gelation‚ Solidification‚ Disinfection System for Medical Waste Disposal 25 GreenDispo (MIDI): Eco-friendly & Energy Efficient Electric Incinerator 26 Dispensers and Disinfectants 26 Air Sanitizer 26 Disinfectant Spray (JeevNasi) 27 Electrostatic Disinfection Machine (eSPRAY & Covid-Spray) 27 Flomop: Floor Disinfectant 28 Foot Operated Hand Washing System (Hasta-Suraksha) 28 Hands Free Hand Sanitization System 29 Hands Free Hand Wash: Foot Controlled Water Tap 29 Hands Free Hand Washing Point-NEERWASH 29 Herbal Soap 30 NEERAKSHA Liquid Disinfectant 30 NEERJANTUK: Hands Free Hand Sanitization Point 31 Scientific Know-how on Ozone-based Air Disinfection for Closed Un-occupied Chambers/rooms 31 Smart Touch-Free (Palm Safe) & Automatic Hand Sanitizer Dispenser (Indoor & Outdoor) 31 Swabee - Floor/kitchen/labtop Electronic Devices Disinfectant 32 UV-Clean Disinfecting Unit (λ-FLASHBOX)
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