Article Pansomatostatin Agonist Pasireotide Long-Acting Release
CJASN ePress. Published on August 25, 2020 as doi: 10.2215/CJN.13661119 Article Pansomatostatin Agonist Pasireotide Long-Acting Release for Patients with Autosomal Dominant Polycystic Kidney or Liver Disease with Severe Liver Involvement A Randomized Clinical Trial 1Division of Nephrology and 1 1 2 1 1 1 Marie C. Hogan , Julie A. Chamberlin, Lisa E. Vaughan, Angela L. Waits, Carly Banks, Kathleen Leistikow, Hypertension, Mayo Troy Oftsie,1 Chuck Madsen,1 Marie Edwards,1,3 James Glockner,4 Walter K. Kremers,2 Peter C. Harris,1 Clinic College of Nicholas F. LaRusso,5 Vicente E. Torres ,1 and Tatyana V. Masyuk5 Medicine, Rochester, Minnesota 2Division of Abstract Biomedical Statistics Background and objectives We assessed safety and efficacy of another somatostatin receptor analog, pasireotide and Informatics, Mayo long-acting release, in severe polycystic liver disease and autosomal dominant polycystic kidney disease. Clinic College of Pasireotide long-acting release, with its broader binding profile and higher affinity to known somatostatin Medicine, Rochester, fi Minnesota receptors, has potential for greater ef cacy. 3Biomedical Imaging Research Core Facility, Design, setting, participants, & measurements Individuals with severe polycystic liver disease were assigned in a PKD Translational 2:1 ratio in a 1-year, double-blind, randomized trial to receive pasireotide long-acting release or placebo. Primary Research Center, Mayo Clinic College of outcome was change in total liver volume; secondary outcomes were change in total kidney volume, eGFR, and Medicine, Rochester, quality of life. Minnesota 4Department of Results Of 48 subjects randomized, 41 completed total liver volume measurements (n529 pasireotide long-acting Radiology, Mayo release and n512 placebo).
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