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EMBL in Finland Join EMBL staff, alumni, their colleagues and networks for an exciting day of science talks and discussions about resources and opportunities at EMBL and in Finland Friday 5 October 2018 Registration is free and open to all: Biomedicum 1, Haartmaninkatu 8, Helsinki www.embl.org/alumni/finland2018 Contact Peter Papagiannis: [email protected] Speakers: Sarah Butcher Pekka Lappalainen Tommi Nyrönen Professor, Faculty of Biological and Group Leader, Institute of Biotechnology, Project Director and Head of ELIXIR Finland Environmental Sciences and HiLIFE Institute of University of Helsinki Node, IT Center for Science (CSC), Espoo Biotechnology, University of Helsinki Tomi Määttä Rainer Pepperkok Mark Daly Predoc, EMBL, Heidelberg Head of Core Facilities, Head of Advanced Light Director, Institute for Molecular Medicine Microscopy Core Facility, Team Leader and Finland (FIMM), University of Helsinki Riitta Maijala Senior Scientist, EMBL, Heidelberg Vice President for Research, Academy of Elina Ikonen Finland, Helsinki Merja Särkioja Academy Professor, University of Helsinki Senior Science Adviser, Academy of Finland, Marja Makarow Helsinki Howy Jacobs Director, Biocenter Finland, Helsinki Professor of Molecular Biology, University of Kai Simons Tampere Johanna Myllyharju Chief Executive Officer, Lipotype, Dresden Scientific Director, Biocenter Oulu and André Juffer Professor, University of Oulu Eero Vuorio Biocomputing Coordinator, Biocenter Oulu Professor Emeritus, University of Turku and Faculty of Biochemistry and Molecular Medicine, University of Oulu Co-organisers: Marja Makarow, Director, Biocenter Finland, Helsinki Peter Papagiannis, Alumni Volunteer Officer, EMBL, Heidelberg Mehrnoosh Rayner, Head of Alumni Relations, EMBL, Heidelberg Antti Siltanen, Coordinator, Biocenter Finland, Helsinki The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world with 1600 employees from more than 80 countries, operating across six sites in Heidelberg, Hamburg, Grenoble, Hinxton (near Cambridge), Rome and Barcelona..

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BOARD MEETING 3/2013 E-MAIL MEETING 30 September 2013 MINUTES INSTITUTE FOR MOLECULAR MEDICINE FINLAND FIMM Nordic EMBL Partnership for Molecular Medicine Title: Meeting of the Board of FIMM 3/2013 Time: Monday, 30 September 2013 Place: E-mail Meeting Chair: Vice Rector, Professor Kimmo Kontula, University of Helsinki Attendees: Dean, Professor Risto Renkonen, Faculty of Medicine, University of Helsinki Research Director, Professor Anna-Elina Lehesjoki, Neuroscience Center, University of Helsinki Professor Kimmo Porkka, Institute of Clinical Medicine, Faculty of Medicine, University of Helsinki Chief Research Officer, Professor Lasse Viinikka, HUS Deputy Director General, Professor Juhani Eskola, THL Vice President, Professor, R&D Biotechnology Anu Kaukovirta-Norja, VTT CEO Pekka Mattila, Desentum Oy Director, Professor Eero Vuorio, Biocenter Finland Head of Laboratory Pekka Ellonen, FIMM Technology Centre Presenter: Director, Professor Olli Kallioniemi, FIMM Secretary: Administrative Manager Reetta Niemelä, FIMM 2(5) INSTITUTE FOR MOLECULAR MEDICINE FINLAND FIMM Nordic EMBL Partnership for Molecular Medicine Meeting of the Board of FIMM 3/2013 1 Appointment of the Evaluation Committee for the evaluation of suggested collaboration be- tween FIMM/University of Helsinki and VTT in the field of metabolomics (presenter: Kallioniemi) 2 Dates of the next meetings 3(5) INSTITUTE FOR MOLECULAR MEDICINE FINLAND FIMM Nordic EMBL Partnership for Molecular Medicine 1 Appointment of the Evaluation Committee for the evaluation of suggested collaboration between FIMM/University of Helsinki and VTT in the field of metabolomics (presenter: Kallioniemi) The Directorship of VTT and the University of Helsinki discussed the possible collaboration between FIMM/University of Helsinki and VTT in the field of metabolomics in May 2013.
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EMBL in Finland
EMBL in Finland Friday 5 October 2018 Biomedicum 1, Lecture Hall 1 Helsinki PROGRAMME 10:00-10:30 Arrival, coffee and registration 10:30-10:40 Welcome remarks 10:30 Marja Makarow, Director, Biocenter Finland, Helsinki (EMBL Heidelberg, Postdoc, 1981-1983; EMBL Council Advisor, 1999-2008; and President of EMBC, 2004-2007) 10:35 Johanna Myllyharju, Scientific Director, Biocenter Oulu and Professor, University of Oulu (EMBL Council Member, 2016-Present) 10:40-12:20 Session 1: EMBL and EMBO opportunities and resources Chair: Johanna Myllyharju, Scientific Director, Biocenter Oulu and Professor, University of Oulu (EMBL Council Member, 2016-Present) 10:40 Rainer Pepperkok, Head of Core Facilities, Head of Advanced Light Microscopy Core Facility, Team Leader and Senior Scientist, EMBL, Heidelberg “EMBL opportunities and resources” 11:20 Kai Simons, Chief Executive Officer, Lipotype, Dresden “EMBL and me” (EMBL Heidelberg, Head of Cell Biology and Biophysics Unit, 1975-2000; and EMBO Council Member, 2004-2009) 11:40 Tomi Määtä, Predoc, EMBL, Heidelberg “My life as a predoc at EMBL” 11:50 Howy Jacobs, Professor of Molecular Biology, University of Tampere “What you can do for EMBO and EMBO can do for you” 12:10 Discussion 12:20-13:20 Lunch and discussion with the speakers PROGRAMME (continued) 13:20-14:30 Session 2: Collaboration opportunities and research infrastructures Panel chair: Merja Särkioja, Senior Science Adviser, Academy of Finland, Helsinki 13:20 Riitta Maijala, Vice President for Research, Academy of Finland, Helsinki “Finland’s strategy
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161104 Press Release Robert Koch Gold Medal 2016 to Kai Simons EN
PRESS RELEASE Robert Koch Gold Medal 2016 to Kai Simons Berlin/Dresden, 4 November 2016: Kai Simons, founding director of the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and managing director of Lipotype GmbH, receives the Robert Koch Medal in Gold for his lifetime achievements, in particular for his characterization of membrane-forming lipids and the development of the lipid raft concept. The Award Ceremony takes place on Friday, November 4th 2016 at the Berlin-Brandenburg Academy of Sciences and Humanities. Simons has spent his life studying cell membranes, wafer-thin bilayers of fat molecules (“lipids”) that surround each cell of the human body and most cellular compartments. Kai Simons discovered floating nano-assemblies of lipids and proteins in the lipid bilayer of cell membranes that reminded him of the log rafts which Finnish lumberjacks used as platforms drifting downstream – hence the name “lipid rafts”. Simons demonstrated the fascinating properties of these rafts: They are fluid and dynamic, they can appear and disappear. Lipid rafts do not only play a significant role as functional platforms in signal transduction and many other membrane processes, but they are also involved in many diseases such as Alzheimer’s disease and AIDS. “I am overwhelmed!” says laureate Kai Simons. “This award is inspiring and I hope that lipids and lipidomics will continue to stimulate molecular life science research, but ultimately also help to improve health and clinical performance”. Kai Simons started the Cell Biology Program at the European Molecular Biology Laboratory (EMBL) in Heidelberg and moved to Dresden in 2001 to build up the Max Planck Institute of Molecular Cell Biology and Genetics.
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CURRICULUM VITAE KAI SIMONS Name
CURRICULUM VITAE KAI SIMONS Name Simons First Name Kai Date of birth May 24, 1938 Born in Helsinki, Finland Nationality Finnish Civil status married to Carola Simons born Smeds, three children Address: Max-Planck-Institute of Molecular Cell Biology and Genetics Pfotenhauerstr. 108, 01307 Dresden Telephone +49 351 210 2800 Fax +49 351 210 2900 e-mail [email protected] Education 1964 MD, University of Helsinki Research Positions 1965 - 1967 Postdoctoral Research fellow at the Rockefeller University in New York (Prof. A.G. Bearn) 1967 - 1975 Investigator at the Finnish Medical Research Council, University of Helsinki 1971 - 1972 Acting Professor of Biochemistry, Medical Faculty, University of Helsinki 1976 - 1979 Professor, Department of Biochemistry, University of Helsinki 1975 - 2000 Group Leader at the European Molecular Biology Laboratory, Heidelberg 1982 - 1998 Coordinator of the Cell Biology Programme, at the European Molecular Biology Laboratory, Heidelberg 1998 - 2006 Director of the Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden Present position 1998 – present Group leader at the Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden Membership in Societies 1975 European Molecular Biology Organisation 1978 Societas Scientarium Fennica 1987 Heidelberg Academy of Sciences 1996 American Academy of Art and Science 1997 Academia Europaea 1997 Foreign Member of the National Academy of Sciences, USA 1998 German Academy of Sciences Leopoldina 2006- Member/Fellow of ScanBalt Academy Honors 1975 Federation
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Lukas A. Huber Biographical Sketch I Studied Medicine at the University
Lukas A. Huber Biographical sketch I studied medicine at the University of Innsbruck. I joined the laboratory of Kai Simons at EMBL in Heidelberg (Germany) as postdoc in epithelial biology until 1994. I then moved to the University of Geneva (Switzerland) and worked in the laboratory of Jean Gruenberg on endocytosis in epithelial cells. In 1996 I started my own laboratory at the I.M.P. in Vienna (Austria) and in 2002 I got appointed as professor and head of the Division of Cell Biology and in 2005 as scientific director of the Biocenter of Innsbruck Medical University (Austria). My research interests have expanded to understanding the spatial and temporal resolution of signaling mechanisms in mammalian cells applying molecular cell biology, mouse genetics and functional proteomics. I initiated and coordinated the FP6 EU program GROWTHSTOP, the Austrian Proteomics Platform of the Austrian Genome Program (GEN-AU), a special research program in Innsbruck entitled “Cell proliferation and Cell Death in Tumors” – SFB021 of the Austrian Science Fund (FWF) and actively participate in several EU programs and also coordinate programs. Since 2009 I am also CSO of the ONCOTYROL center of personalized cancer medicine in Innsbruck, Austria and since 2012 founder and scientific director of the Austrian Drug Screening Institute (ADSI). Curriculum vitae Biozentrum der Medizinischen Universität Innsbruck Sektion für Zellbiologie Innrain 80-82 A-6020 Innsbruck Austria Tel: +43-512-9003-70170 Web: http://biocenter.i-med.ac.at/ http://www.oncotyrol.at/ http://www.adsi.ac.at/ Email [email protected] Date of birth 4 July 1961 Place of birth Vienna, Austria Citizenship Austrian Education 1980 Matura, Humanistisches Gymnasium Paulinum, Schwaz, Austria 1989 MD, Medical School, University of Innsbruck, Austria Career History 1987-1989 M.D.
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Lipid Function in Health and Disease 27 – 30 September 2019 | Dresden, Germany
Lipid function in health and disease 27 – 30 September 2019 | Dresden, Germany ORGANIZER SPEAKERS Kai Simons Alan Bridge Jens Brüning Robin Klemm Max Planck Institute of Molecular Cell Swiss Insitute of Bioinformatics Max Planck Institute for University of Zurich, CH Biology and Genetics, DE Metabolism Research, DE Allan Tall Rose Goodchild Columbia University College of Jodi Nunnari VIB-KU Leuven Center for Brain & CO-ORGANIZERS Physicians & Surgeons, US University of California, US Disease Research, BE Triantafyllos Chavakis Andrej Shevchenko Kai Simons Rosemary Cornell University Hospital Dresden, DE Max Planck Institute of Molecular Max Planck Institute of Molecular Simon Fraser University, US Cell Biology and Genetics, DE Cell Biology and Genetics, DE Ünal Coskun Samuli Ripatti Paul Langerhans Institute Dresden Arun Radhakrishnan Karin Reinisch Institute for Molecular Medicine, /Helmholtz Zentrum München, DE University of Texas, US Yale School of Medicine, US FI Elina Ikonen Bruno Antonny Mihai Netea Shamshad Cockcroft University of Helsinki, FI Institute of Molecular and Cellular Radboud Universität, NL University College London, UK Pharmacology, FR Mikael Simons Suzanne Pfeffer REGISTRATION Doris Höglinger Technical University Munich, DE Stanford University, US Heidelberg Univeristy, DE Registration deadline Naomi Taylor Theodore Alexandrov 31 May 2019 Edda Klipp NIH National Cancer Institute, US EMBL, DE Humboldt-Universität zu Berlin, DE Nicola Zamboni Triantafyllos Chavakis Student/postdoc ............ 300 EUR ETH Zurich, CH
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Suzanne Eaton: 1959–2019 Our Mentor, Suzanne Eaton, Tragically Fell Victim to Homicide on 2 July 2019
obituary Suzanne Eaton: 1959–2019 Our mentor, Suzanne Eaton, tragically fell victim to homicide on 2 July 2019. The circumstances of her disappearance and death have shocked scientists and the public alike, worldwide. From the moment she went missing, the members of her family, laboratory and colleagues have received admirable and touching support from the scientifc community. This outpouring stands testament to the inspiration that Suzanne—a world-leader scientist, creative pioneer and beloved mentor—is to all of us. uzanne sought diverse training range, are fascinating unsolved questions.” from early on in her career, first She was awestruck by nature and its Sby tackling the regulation of gene grandeur. Her views towards biology were expression as a graduate student with deeply informed and shaped by her regular Kathryn Calame, then by investigating exercise in philosophy. She wanted to tissue patterning at the developmental and understand biological processes on a grand molecular levels as a postdoc with Tom scale, hence her fascination in something so Kornberg and Kai Simons. She continued to fundamental as the effects of temperature. leverage her curiosity and large breadth of Leading a large group of scientists from knowledge to answer fundamental biological various disciplines—a ‘Forschergruppe’ questions by integrating concepts from (a german word she used frequently to refer disparate disciplines. to this group)—she took on the mammoth As Suzanne started her first independent task of asking how temperature coordinates position at the European Molecular biological processes at multiple levels: cell, Biology Laboratory (EMBL) in 1997, tissue and organism. In 2018, she published we had the privilege to observe the an article on the effects of temperature on principles that guided her research.
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Model Systems, Lipid Rafts and Cell Membranes
30 Apr 2004 18:28 AR AR214-BB33-13.tex AR214-BB33-13.sgm LaTeX2e(2002/01/18) P1: FHD 10.1146/annurev.biophys.32.110601.141803 Annu. Rev. Biophys. Biomol. Struct. 2004. 33:269–95 doi: 10.1146/annurev.biophys.32.110601.141803 Copyright c 2004 by Annual Reviews. All rights reserved First published online as a Review in Advance on February 2, 2004 MODEL SYSTEMS,LIPID RAFTS, AND CELL MEMBRANES1 Kai Simons Max-Planck-Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany; email: [email protected] Winchil L.C. Vaz Departamento de Qu´ımica, Universidade de Coimbra, 3004-535 Coimbra, Portugal; email: [email protected] Key Words sphingolipids, cholesterol, phase immiscibility, detergent resistance, membrane proteins ■ Abstract Views of how cell membranes are organized are presently changing. The lipid bilayer that constitutes these membranes is no longer understood to be a homogeneous fluid. Instead, lipid assemblies, termed rafts, have been introduced to provide fluid platforms that segregate membrane components and dynamically com- partmentalize membranes. These assemblies are thought to be composed mainly of sphingolipids and cholesterol in the outer leaflet, somehow connected to domains of unknown composition in the inner leaflet. Specific classes of proteins are associated with the rafts. This review critically analyzes what is known of phase behavior and liquid-liquid immiscibility in model systems and compares these data with what is known of domain formation in cell membranes. CONTENTS INTRODUCTION .....................................................270
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Phase Coexistence and Connectivity in the Apical Membrane of Polarized Epithelial Cells
Phase coexistence and connectivity in the apical membrane of polarized epithelial cells Doris Meder*, Maria Joao Moreno†, Paul Verkade*, Winchil L. C. Vaz*†, and Kai Simons*‡ *Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany; and †Departamento de Quı´mica,Universidade de Coimbra, 3004-535 Coimbra, Portugal Contributed by Kai Simons, November 14, 2005 Although it is well described in model membranes, little is known (15) and from fluorescence anisotropy measurements of diphe- about phase separation in biological membranes. Here, we provide nyl chain-labeled phosphatidylcholine revealing liquid-ordered evidence for a coexistence of at least two different lipid bilayer environments in the plasma membrane of mast cells (16) and in phases in the apical plasma membrane of epithelial cells. Phase vivo images of liquid-ordered domains in macrophages labeled connectivity was assessed by measuring long-range diffusion of with 6-lauroyl-2-dimethylaminonaphthalene (17). However, the several membrane proteins by fluorescence recovery after photo- interpretations of the results obtained in all three cases may be bleaching in two polarized epithelial cell lines and one fibroblast questioned because of the invasive nature of the techniques. Also cell line. In contrast to the fibroblast plasma membrane, in which high-speed, single-molecule imaging has failed to detect lipid all of the proteins diffused with similar characteristics, in the apical domains in resting fibroblasts (18). membrane of epithelial cells the proteins could be divided into two In this work we have studied the long-range translational groups according to their diffusion characteristics. At room tem- diffusion of several proteins associated with the apical mem- perature (Ϸ25°C), one group showed fast diffusion and complete brane of epithelial cells [Madin-Darby-canine kidney (MDCK) recovery.
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New Heads of Units for EMBL Heidelberg Council
40 EMBL August 2007 &Newslettercetera of the European Molecular Biology Laboratory Council Meeting: Australia to join as associate member state Delegates at this summer’s EMBL Council meeting in Hamburg agreed that Australia will become EMBL’s first associate member state. The associate membership is planned to officially start in January next year and will initially last for seven years. Other news from the meeting includes Luxembourg’s ratification to become EMBL’s 20th full member state, the appointment of Anne Ephrussi as the new Unit Coordinator for Developmental Biology, Detlev Arendt’s promotion to Senior Scientist and much more. pages 2 and 3 New heads of units for EMBL Heidelberg Following the departure at the end of last year of Structural and Computational Biology Unit coordi- nator Luis Serrano to the Center for Genomic Regulation in Barcelona, former Deputy Head of EMBL Grenoble Christoph Müller (right) arrived at EMBL Heidelberg at the start of August to fill his shoes as Joint Coordinator alongside Peer Bork. In addition, Anne Ephrussi has been appointed as the new Unit Coordinator for Developmental Biology. Inside, both talk about their plans for the units. pages 2 and 3 EMBL-EBI throws open the doors to training facilities Next time you pay a visit to EMBL-EBI, take a look at their new IT training suite, part of the newly com- pleted East Wing. It’s where visitors will receive tuition in the EBI’s bioinformatics resources at its Genome Campus location for the first time. With 40 permanent workstations and the option to dou- ble the room’s capacity for an additional 40 laptop-based users, the state-of-the-art suite also features touchscreen audio-visual controls, window blinds and lights.
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New Beginnings: Getting the Kick I Needed
TURNING POINTS New beginnings: getting the kick I needed Kai Simons I come from the north, from the periphery At that time, in the 1960s, we had few my short visit. I told him about my work in try- of Europe — Finland. I studied medicine in international contacts in Helsinki and I had ing to purify Gc protein variants and to find out Helsinki, but actually I wanted to do research difficulty in finding a lab where I could do how these variants differ at the molecular level. and first I tried clinical research. A classical postdoctoral work. I saw a paper by Alexander I recall how Brian not so gently asked me, “Kai, area of Finnish medicine was vitamin B12. Bearn from the Rockefeller University, on do you really think this work is interesting?” Why? Because a large part of the Finnish popu- Wilson’s disease, a condition characterized by Deep inside me I knew this work was boring lation was infected with the broad tapeworm, a excessive deposition of copper in all tissues, but I needed this kick from Brian. “Don’t you parasite that colonizes the intestine and needs caused by increased absorption of copper from have another more interesting project that you vitamin B12 for growth. Some people infected the small intestine. Somehow, a serum protein would want to tackle?” Then, I told him about with the tapeworm develop pernicious anae- called ceruloplasmin was involved. I joined the Semliki Forest virus membrane and in a mia, which is why vitamin B12 was an area for Bearn’s lab only to find out that they no longer split second he convinced me that this was the medical research.
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CV Kai Simons
Curriculum Vitae Prof. Dr. Kai Simons Name: Kai Simons Geboren: 24. Mai 1938 Forschungsschwerpunkte: Zellmembran, zelluläre Polarität, Membrantransport in Zellen, „Lipid Rafts“‐Modell Kai Simons ist ein finnischer Mediziner und Biochemiker. Er forscht zur Zellbiologie, insbesondere zur Zellmembran und deren Funktionen. Er etablierte das Konzept der „Lipid Rafts“ als Organisationsprinzip der Zellmembran. Akademischer und beruflicher Werdegang seit 2012 Geschäftsführer der Lipotype GmbH seit 2007 Direktor emeritus am Max‐Planck‐Institut für molekulare Zellbiologie und Genetik, Dresden (MPI‐CBG) 1998 ‐ 2006 Direktor am MPI‐CBG 1998 ‐ 2014 Forschungsgruppenleiter am MPI‐CBG 1982 ‐ 1998 Koordinator des Cell Biology Programme am Europäischen Laboratorium für Molekularbiologie (EMBL), Heidelberg 1976 ‐ 1979 Professor für Biochemie an der Universität Helsinki, Finnland 1975 ‐ 2000 Gruppenleiter am EMBL 1971 ‐ 1972 Professor für Biochemie an der Universität Helsinki 1967 ‐ 1975 Forscher am Finnish Medical Research Council, Universität Helsinki 1965 ‐ 1967 Postdoktorand an der Rockefeller University, New York, USA 1964 Promotion (M.D.) Studium der Medizin an der Universität Helsinki Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org 1 Funktionen in wissenschaftlichen Gesellschaften und Gremien 2012 Mitglied des wissenschaftlichen Beirats des Danish Stem Cell Center, Kopenhagen, Dänemark 2012 Mitglied im wissenschaftlichen Komitee des A.C. Camargo Hospital, São Paulo, Brasilien 2011 Mitglied des wissenschaftlichen Beirats des Biotechnology
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