Ⅰ．Overview of subsidiaries and affiliates The Takeda Group consists of 165 companies, including the parent company submitting these consolidated financial statements, 148 consolidated subsidiaries and 16 equity method affiliates. The following chart shows the main business areas of the Takeda Group, the position of the companies that make up the Group within their respective areas of business, and relationships with each business segment. Japan Overseas

【Ethical drugs】 【Ethical drugs】 TakedaCompany Pharmaceutical Limited ★Takeda America Holdings, Inc. 《》 ★Nihon Pharmaceutical Co., Ltd. 《Production/Sales/ ★Takeda Pharmaceuticals International, Inc. 《Supervision of the U.S. Research/Development》 Sales & Marketing/ ★Takeda Bio Development Center 《Development》 Research/ Development》 Limited ★Takeda Pharmaceuticals U.S.A., Inc. 《Sales》 ★Takeda Canada Inc. 《Sales》 And others ★Millennium Pharmaceuticals, Inc. 《Sales/Research/ Development》 ★Takeda California, Inc. 《Research》 ★Envoy Therapeutics, Inc. 《Research》 ★Takeda Vaccine (Montana), Inc. 《Research/Development 》 ★Takeda Development Center Americas, Inc. 《Development 》 【Consumer Healthcare】 ★Takeda Ventures, Inc. 《Research-related Venture Investment 》

★Takeda Healthcare Products Co., Ltd. 《Production》 ◎Amato Pharmaceutical Products, Ltd. 《Production/Sales/ ★Takeda Holdings B.V. 《Holding Company》 Research/Development》 ★Takeda A/S 《Holding Company》 ★Takeda Pharmaceuticals International GmbH 《Supervision of Sales & Marketing for areas other than Japan and the U.S.》 ★Takeda Pharmaceuticals Europe, Limited 《Supervision of Europe Sales & Marketing》 【Others】 ★Takeda GmbH 《Production/Sales/ Research/Development 》 ★Takeda Pharma Vertrieb GmbH & Co. KG 《 》 ★Wako Pure Chemical Industries, Ltd. 《Production/Sales》 Sales ★Takeda Italia S.p.A. 《Production/Sales》 ★Mizusawa Industrial Chemicals, Ltd. 《Production/Sales》 ★Takeda GmbH 《Production/Sales 》 ★Takeda Pharma Ges.m.b.H 《Sales 》 And others ★Takeda France S.A.S. 《Sales》 ★Takeda Pharma A/S 《Production/Sales/ Development》 ★Takeda Nycomed AS 《Production/Sales》 ★Takeda SCA/CVA 《Sales》 ★Takeda Christiaens SCA/CVA 《Production/Sales》 ★Takeda UK Limited 《Sales》 ★Oy Leiras Takeda Pharmaceuticals Ab 《Sales》 ★Takeda Pharma AG 《Sales》 ★Takeda Farmaceutica Espana S.A. 《Sales》 Sales of products Consign processing ★Takeda Nederland B.V. 《Sales》 ★Takeda Pharma AB 《Sales》 Supply of raw materials Others ★Takeda Pharma Sp.z.o.o. 《Production/Sales》 ★Takeda Hellas S.A. 《Sales》 ★：Consolidated subsidiaries ★Takeda Ireland Limited 《Production》 ★Takeda Cambridge Limited 《Research》 ◎：Equity method affiliates ★Takeda Development Centre Europe Ltd. 《Development 》

★Takeda Pharmaceuticals Limited 《Sales》 Liability Company ★Takeda Ukraine LLC 《Sales》

★Takeda Distribuidora Ltda. 《Sales》 ★Multilab Indústria e Comércio de 《Production/Sales/ Produtos Farmacêuticos Ltda. Research/Development 》 ★Takeda Pharma Ltda. 《Production/Sales》 ★Takeda S.A. de C.V. 《Production/Sales 》 ★Takeda S.R.L. 《Sales》 ★Takeda Pharma, S.A. 《Production/Sales》

★Takeda (China) Holdings Co., Ltd. 《Holding Company/ Development》 ★Takeda Pharmaceuticals (Asia Pacific) Pte. Ltd. 《Supervision of Asia Sales & Marketing》 ★Guangdong Techpool Bio-Pharma Co., Ltd. 《Production/Sales/ Research/Development》 ★Takeda Pharmaceutical (China) 《Sales》 Company Limited ★Tianjin Takeda Pharmaceuticals. Co., Ltd. 《Production/Sales》 ★Takeda Pharmaceuticals Korea Co., Ltd. 《Sales》 ★Takeda (Thailand), Ltd. 《Sales》 ★Takeda Pharmaceuticals Taiwan, Ltd. 《Sales》 ★P.T. Takeda Indonesia 《Production/Sales》 ★Takeda Pharmaceuticals (Philippines), Inc. 《Sales》 ■ Number of subsidiaries and affiliates by business segment ★Takeda Singapore Pte. Limited 《Research》 ＜ FY2013 2Q ＞ ★Takeda Development Center Asia, Pte. Ltd. 《Development》 Consolidated subsidiaries Companies applied"equity method" Total Japan Overseas Japan Overseas ★Takeda (Pty.) Ltd. Ethical drugs 8 123 1 4 136 《Sales》 ★Takeda Pharmaceuticals Australia Pty. Ltd. 《 》 Consumer healthcare 1 0 1 0 2 Sales Others 10 6 8 2 26 And others Total 19 129 10 6 164 vs. FY2012 04004

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