Non-Canonical Odor Coding Ensures Unbreakable Mosquito Attraction to Humans
bioRxiv preprint doi: https://doi.org/10.1101/2020.11.07.368720; this version posted November 8, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Non-canonical odor coding ensures unbreakable mosquito attraction to humans Meg A. Younger1,2,7*, Margaret Herre1,2,7*, Alison R. Ehrlich1,4, Zhongyan Gong1,5, Zachary N. Gilbert1, Saher Rahiel1, Benjamin J. Matthews1,3,6, Leslie B. Vosshall1,2,3* SUMMARY Female Aedes aegypti mosquitoes show strong innate attraction to humans. This chemosensory behavior is critical to species survival because females require a blood- meal to reproduce. Humans, the preferred host of Ae. aegypti, produce a complex blend of odor cues along with carbon dioxide (CO2) that attracts females ready to bite. Mosquitoes detect these cues with heteromeric ligand-gated ion channels encoded by three different chemosensory receptor gene families. A common theme in other species is that olfactory neurons express a single receptor that defines their chemical specificity and that they ex- tend axons that converge upon dedicated glomeruli in the first sensory processing center in the brain. Such an organization permits the brain to segregate olfactory information and monitor activity of individual glomeruli to interpret what smell has been encountered. We have discovered that Ae. aegypti uses an entirely different organizational principle for its olfactory system. Using genetic strains that label subpopulations of olfactory neurons, we found that many neurons co-express multiple members of at least two of the chemosen- sory receptor families.
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