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NATIONAL INSTITUTE OF EPIDEMIOLOGY (Indian Council of Medical Research) Annual Report 2013-14 Second Main Road Tamil Nadu Housing Board, Ayapakkam Chennai - 600 077 Telephone : 26136204 / 26821600 Fax : 044-26820464 E-mail : [email protected] Web : www.nie.gov.in Section No. TABLE OF CONTENTS Page no. 1.0 DISEASE SURVEILLANCE AND OUTBREAK RESPONSE 1.1 National hospital based Rotavirus surveillance network 1 1.2 Hospital based surveillance for Bacterial Meningitis 3 Data Management System for ICMR Antimicrobial Resistance 1.3 6 Surveillance Network 1.4 OUTBREAK INVESTIGATIONS 7 An outbreak of dengue fever in Demdema village of Rajganj block and 1.4.1 7 Siliguri municipal area, Jalpaiguri district, West Bengal 2013 Measles outbreak in Kilapudi village, Pallipattu, Tiruvallur, Tamilnadu, 1.4.2 8 India, 2014 An outbreak of scrub typhus in Senapati district, Manipur State, India, 1.4.3 9 2012 1.4.4 An outbreak of Hepatitis E in Solan Town, Himachal Pradesh, 2014 10 An outbreak of acute gastroenteritis in Molmigre village, Kherapara 1.4.5 10 PHC, West Garo Hills District, Meghalaya, 2013 Outbreak of Hepatitis-A at Kaliganj Block, Nadia District, West Bengal, 1.4.6 11 India, 2013 Combination of low vaccine coverage and effectiveness contributed 1.4.7 to measles outbreak in an urban area of Murshidabad District, West 12 Bengal, Eastern India, 2014 1.4.8 Cholera outbreak in Gotakhindaki, Bijapur District, Karnataka, 2013 13 Acute diarrhoeal disease outbreak in 15 Mile, Byrnihat, Ri-Bhoi District, 1.4.9 13 Meghalaya, 2013 Measles outbreak in Pimpalgaon (Baswant) village of Niphad Block of 1.4.10 14 Nashik District, Maharashtra, India, 2014 Outbreak of dengue fever in Siliguri Municipal Corporation, Darjeeling, 1.4.11 15 West Bengal, India, 2013 An outbreak of acute diarrhoeal disease in an urban locality of 1.4.12 16 Mubarakpur, Azamgarh District, Uttar Pradesh, India, 2013 Investigation of Hepatitis E outbreak in Chopadyachiwadi, Beed District, 1.4.13 17 Maharashtra, India 2013 Dengue outbreak investigation at Pudhukottai district, Tamil Nadu, 1.4.14 18 2012 2.0 LEPROSY 19 Multi-centric study of the ICMR task force on leprosy: ‘Socio-cultural 2.1 features and stigma of leprosy for treatment & control in general health 19 services in India: Cultural epidemiological study’ Occurrence of relapse, non-responsiveness to treatment in leprosy and 2.2 screening of M. leprae isolates for drug resistance using molecular and 22 mouse footpad techniques Endemicity of leprosy and utilization of health services in selected areas 2.3 25 of Uttar Pradesh, Chhattisgarh and Tamil Nadu WHO / TDR multi-centric trial on ‘Uniform MDT regimen for all types of 2.4 28 leprosy patients’ (CTRI/2012/05/002696) 3.0 HIV / AIDS 30 Mapping and Size Estimation of Hijras and other Transgender 3.1 30 Populations in states of India Study to understand prevention of HIV and explore barriers for women: 3.2 A multi-stakeholder perspective on vaginal microbicides and other HIV 32 new prevention technologies (NPTs) Comprehensive approach to condom promotion yields results among 3.3 long distance truckers who are clients of female sex workers in India: 33 The case of Avahan interventions Assessment of services for prevention and management of infertility in 3.4 35 the primary health care system in India 4.0 HEALTH SYSTEMS RESEARCH 37 Causes of referral out of female clients admitted in Comprehensive Emergency Obstetric and Neonatal Care (CEmONC) centres and 4.1 37 maternal and foetal outcomes: A cross sectional study, Tamil Nadu, India, 2012-13 Evaluation of hypertension management in the Non-Communicable 4.2 Disease program in Chennai, Theni and Villupuram districts : Tamil 39 Nadu Health Systems Project Coverage and effectiveness of Japanese Encephalitis vaccine, Gorakhpur, 4.3 44 Uttar Pradesh 5.0 PUBLIC HEATH TRAINING PROGRAMMES 46 5.1 The ICMR School of Public Health 46 5.1.1 Dissertation projects by MPH scholars, 2011-13 46 Estimation of injection safety practices in health care facilities and 5.1.1.1 awareness of safe injection among prescriber, provider and community 46 in Nicobar District, India, 2013 Status of Village Health Sanitation and Nutrition Committees in district 5.1.1.2 47 Chamba, Kangra and Una, Himachal Pradesh, 2013 The level of preparedness of households and associated factors for cyclone 5.1.1.3 disasters in rural communities of 3 coastal blocks of Cuddalore District, 47 Tamil Nadu Jan-March 2013 Infl uence of Social Risk Factors on Child Immunization in four tribal– 5.1.1.4 48 dominated states of North-east Adherence and factors associated with adherence in Diabetic treatment 5.1.1.5 among Patients attending public health care settings in Villupuram 48 District Tamil Nadu, January - March 2013 Utilization of services under Janani Shishu Suraksha Karyakram (JSSK) 5.1.1.6 for Institutional deliveries in Government Health facilities, Sirmaur 48 district, Himachal Pradesh, India, 2013 Prevalence of chronic complications of diabetes among type 2 diabetic 5.1.1.7 patients treated at primary health centers in Kanchipuram district of 49 Tamil Nadu, India-2013 Barriers to temporary modern contraceptive use among eligible couples 5.1.1.8 49 of Nongstoin Block, West Khasi Hills District, Meghalaya Factors associated with defi nite birth asphyxia among newborns of low- 5.1.1.9 risk antenatal mothers in Poonamallee Health Unit District, Tamil 49 Nadu, 2013: Hospital-based case-control study National Rural Health Mission’s Community-based monitoring of health 5.1.1.10 services and status of key health parameters at village level, Tamil 50 Nadu, 2013 Willingness for cervical cancer, breast cancer screening and associated 5.1.1.11 factors for not willing among women attending Primary health centres in 50 Villupuram district, Tamil Nadu, 2013 Awareness of cervical cancer and utilization of screening for cancer 5.1.1.12 cervix among female health care workers in Kancheepuram district of 50 Tamil Nadu State in India 2013 Comparison of knowledge and practice among the trained and not trained Auxiliary Nurse Midwife and Staff Nurse regarding 5.1.1.13 51 core skills of Skilled Birth Attendance in Birbhum district, West Bengal, India, 2012-2013 Burden of retinopathy amongst diabetic patients attending public health 5.1.1.14 51 facilities in Kancheepuram District, Tamil Nadu, India 2013 Process evaluation of Integrated Management of Neonatal and Childhood 5.1.1.15 52 Illnesses (IMNCI) Program in Thanjavur district, Tamil Nadu, 2013 Behavioural risk factors for Non Communicable diseases among 5.1.1.16 52 adolescents of rural areas, Kancheepuram district, Tamilnadu 2013. Newborn care practices among mothers and status of the Home Based 5.1.1.17 Postnatal Care (HBPNC) programme under National Rural Health 52 Mission in Mewat, Haryana, India, 2013 53 5.1.2 Field projects by scholars of MPH 5th cohort (2012-14) 5.2 Postgraduate Diploma in HIV Epidemiology 55 5.3 Centrally Coordinated Bioethics education in India 55 6.0 WORKSHOPS / TRAINING PROGRAMMES ORGANIZED 56 7.0 PUBLICATIONS 59 8.0 LIST OF STAFF MEMBERS 61 1. DISEASE SURVEILLANCE AND OUTBREAK RESPONSE 1.1 National Hospital Based Rotavirus Surveillance Network Project Principal Investigator (NIE) Sanjay Mehendale (National Coordinator) Co-Investigators (NIE) C. P. Girish Kumar, S. Venkatasubramanian Coordinating center- NIE; Referral centers- NIV, CMC, NICED, AIIMS ; Regional centers- Collaborating Institute/s NIE, RMRCs at Port Blair, Jabalpur, Dibrugarh, Belgaum, Bhubaneshwar& RMIMS Patna; Peripheral centers- ~30 hospital sites across the country Funding Agency ICMR (extramural) Total budget ~20 Crores (all centers for 4 years) Start date Phase I – 2012; Phase II – 2013 Study Period 4 years Background 2. To determine the age, seasonal distribution and outcomes of rotavirus- In India, an estimated 100,000 children die associated disease among the population each year because of rotavirus gastroenteritis. under surveillance, including monitoring A multicentric surveillance system in India was trends over time. established jointly in 2005 under the supervision of DG, ICMR, India and CDC, Atlanta. To strengthen 3. To investigate the molecular epidemiology this network the surveillance activities have been of rotavirus in India by typing the G and expanded in a phased manner, as recommended P type and characterization of untypeable by the National Technical Advisory Group on strains by sequencing. Immunizations. 4. To estimate the economic burden of Objectives rotavirus gastroenteritis seen at hospitals 1. To establish a national hospital based by standardized costing studies. surveillance to examine long term trends Methods and pattern of diarrhea attributable to rotavirus among children < 5 yr of age All children less than 5 years of age admitted with seen at in-patient facilities acute diarrhoea were enrolled after obtaining ANNUAL REPORT 2013-14 1 informed and written consent from parents Bhubaneswar, one CRS under NIE Chennai / guardians. Clinical information and stool (Fig 1). specimens were obtained. The stool samples were A total of 5574 children were enrolled and 5311 stool tested for presence of rotavirus by ELISA. Rotavirus samples were collected in the study from September positive specimens were further characterized 2012 to March 2014. Out of 5574 enrolled, 47% to determine the G and P types using PCR based (2500/5311) of the stool samples were positive for assays. Lab QA/QC exercises were coordinated by rotavirus. The region wise rotavirus positivity CMC, Vellore. Data entry and validation were done rates are shown in fi gure 2. The distribution of using the online data entry module developed and major rotavirus genotypes viz. G1P[8], G2P[4], hosted on the NIE website. Data management for G9P[8], G12P[6], G12P[8] are shown in Figure 3. the project was done by NIE. Current status The phase I of the surveillance was launched on 19th September 2012 in 8 Clinical Recruitment Sites (CRS) under CMC Vellore and one CRS under RMRC Port Blair.