RESEARCH REPORT
Our research. Our people. Southern Health is Victoria’s most integrated OUR VISION public health service uniquely providing To provide better health for our community health care across the entire lifespan – – Southern Health will be an Australian leader in improving the health and from newborns and children, to adults, wellbeing of our community. the elderly, their families and carers. Our services are provided from over 40 OUR PURPOSE care locations across south east Melbourne, To plan and deliver safe, effective and people-focused health care and services that including major tertiary and secondary anticipate and respond to our community’s hospitals, an extensive network of health needs by:
rehabilitation, community health and g collaborating with other service providers
mental health facilities and aged g maximising the use of all available resources
residential care centres. g working together to realise people’s potential
g fostering knowledge-based practice and Strong medical, clinical and translational continuous improvement. research across all clinical disciplines is To promote and provide quality education and integral to improving the health and research relevant to health care. wellbeing of our community.
Monash Health Translation Precinct MELBOURNE CBD Southern Health Deakin University Prince Henry’s Institute Monash Institute of Medical Research Monash University CSIRO Monash University Monash Medical Centre Australian Moorabbin Synchrotron Monash Medical Centre,Sgva Clayton Kingston Cockatoo Dandenong Centre Hospital Dandenong Doveton
Berwick
Casey Hospital Pakenham
Cranbourne
Cranbourne Integrated Care Centre CONTENTS
4 Message from the Chair of the Board and 62 Mental Health: Psychological and Chief Executive Behavioural Medicine 4 Director of Research Strategy’s report 64 Mental Health: Southern Synergy 5 Our year at a glance 67 Monash Children’s 6 Reducing disability in children with 69 Monash Newborn cerebral palsy 71 Melbourne Children’s Sleep Centre 6 8 Cancer prognosis indicator breakthrough 72 Nephrology 10 Improving dialysis treatment 74 Neurosciences 12 Leading the way in emergency care 76 Nursing: Deakin - Southern Health 14 2010 Emerging Researcher Fellows Nursing Research Centre 15 A calming influence on the stress of 78 Obstetrics and Gynaecology dementia 81 Ophthalmology 16 Research governance 82 Pathology: Anatomical 17 Support our research 84 Pathology: Biochemistry 85 Pharmacy 18 Research Services 86 Respiratory and Sleep Medicine 10 23 Southern Health Research Week 2010 88 Rheumatology 24 Research Group Reports 90 Supportive and Palliative Care 24 Ageing: Monash Ageing Research Centre 91 Urology (MONARC) 93 Vascular Sciences 30 Allied Health Monash Health Translation Precinct MELBOURNE CBD 32 Anaesthesia and Peri-operative Medicine 95 Monash Health Translation Precinct Southern Health 33 Cardiology: MonashHEART and Monash Partner Reports Deakin University Prince Henry’s Institute Cardiovascular Research Centre 95 Monash Institute of Medical Research Monash Institute of Medical Research 36 Cardiothoracic Surgery Monash University 99 Prince Henry’s Institute CSIRO Monash University 38 Clinical Immunology 101 Southern Clinical School Monash Australian 8 39 Colorectal Surgery Medical Centre Moorabbin Synchrotron 40 Diabetes Unit 104 Collaborations Monash Medical 41 Diagnostic Imaging 104 BioGrid Australia Centre, Clayton Sgva 42 Emergency Medicine 106 Victorian Cancer Biobank Kingston Cockatoo Dandenong 45 Endocrinology Centre Hospital Dandenong 47 Gastroenterology and Hepatology 107 Postgraduate Students Doveton 49 Haematology Berwick 50 Infectious Diseases and Microbiology 120 Funding Sources 52 Infection Control and Epidemiology Casey 123 Southern Health and MHTP Hospital 53 Intensive Care Publications Pakenham 12 55 Medical Oncology 123 Journal articles 57 Mental Health: Centre for Developmental Cranbourne Psychology and Psychiatry 153 Book chapters Cranbourne 59 Mental Health: Clinical Trials Research 155 Books Integrated Group (Psychiatry) Care Centre 60 Mental Health: Early in Life (infant to 157 Collaborations and Partnerships youth) Mental Health Service 15 MESSAGE FROM THE CHAIR OF THE BOARD AND CHIEF EXECUTIVE
We are pleased to present Southern This year’s Research Report illustrates Health’s Research Report 2010. the vast range of research being undertaken with a focus on understanding Over the last year Southern Health, in the needs of Victorians living in the collaboration with our valued research South-East of Victoria. The feature stories partners, has continued to mature as a demonstrate our commitment to translational world class research organisation. 2010 research from timely interventions in our has been a year of change and achievement. Emergency Departments to life-changing The Southern Health Research Plan outcomes for our dialysis patients in the 2010-2013 was developed after a broad Nephrology Department. stakeholder consultation process and approved by the Southern Health Board. The printed version of our Research Report In this plan, we have detailed our new highlights just some of the outstanding research vision for Southern Health: research achievements of Southern Health in conjunction with our academic partners “To be a health service that integrates including the Prince Henry’s Institute, Monash excellence in clinical services, education Institute of Medical Research, Monash and research. Southern Health will provide University, philanthropic, government and a supportive and dynamic environment commercial partners. We would encourage for health care professionals to conduct you to read the full on-line version of the world-class clinical and translational research Southern Health Research Report 2010 which that drives improved clinical practice.” provides comprehensive information on the research activities for each department, key This is an exciting step forward for Southern collaborators and Monash Health Translation Health and underscores the central Precinct partners. importance of our research in the delivery of safe and effective person-centred care. On a final note, we would like to acknowledge Professor John Funder AO, Director of Barbara Yeoh In 2010 Southern Health also undertook a Research Strategy for his contribution to Chair, Board of Directors review of its research governance framework Southern Health for over two years between to ensure that we continued to maintain the June 2008 and December 2010. John highest standards of research governance chaired a number of research committees and ethics. In August 2010, the National including the Research Advisory Council and Health and Medical Research Council’s was instrumental in the development of the certification of Southern Health’s Human Research Strategic Plan 2010-2013. We take Research Ethics Committee again evidenced the opportunity to thank John and wish him Shelly Park our leadership in this field. all the best in his retirement. Chief Executive
DIRECTOR OF RESEARCH STRATEGY’S REPORT
In 2010 there were many reasons for Towards the end of the year, the Southern celebration of research at Southern Health, Health Board signed a memorandum of and one for continuing hard work. understanding with Monash University to develop a true Academic Health Service, For four years we have awarded Emerging and Southern Health and partners performed Researcher Fellowships, of $30,000 for a at twice the national average in securing start-up year; on reviewing the program, NHMRC grants. the cause for celebration is that over half those awarded were continuing to a PhD. The current Victorian government is The Southern Health Senior Medical Staff committed to Academic Health Centres; Research Week in May was the best yet, with my swansong, post-election, was to spend excellent presentations and over 160 posters an hour briefing the current Victorian from hospital staff and the affiliated institutes. Minister for Health and Ageing, the The Research Directorate maintained its Honourable David Davis, on Monash OA status on review, a tribute to Malar Health Translation Precinct. Thiagarajan and her team. The Southern I would like to extend a very sincere Health Research Advisory Council committee welcome to my successor, Professor Stephen was reconfigured, to encourage more Holdsworth: from me, ave atque vale. participation by hospital clinicians in research Professor John Funder AO across Southern Health. Director of Research Strategy
4 Southern Health Research Report 2010 5 OUR YEAR AT A GLANCE 675 $23 million Projects underway NHMRC grant funding there were more than 675 research projects underway more than $23 million in NHMRC grant funding involving patients, either in clinical drug or device trials, awarded to Southern Health and MHTP partners or addressing key questions in clinical medicine, public health and the social sciences 225 $5.1 million New research projects Cancer research grants there were 225 new research projects approved by the more than $5.1 million in cancer research grants awarded Southern Health Human Research Ethics Committees to Southern Health and MHTP partners in 2010 255 $6 million Clinical drug or device trials Commercially sponsored clinical trials there were 255 clinical drug or device trials underway, more than $6 million funding for commercially sponsored including 16 phase 1, 47 phase II, 109 phase III, 17 phase clinical trials by leading pharmaceutical companies and IV trials biotechnology companies for national and international clinical research 117 806 Cancer clinical research Publications there were 117 cancer clinical research projects underway there were 742 journal articles published in peer reviewed in 2010 journals, 53 book chapters and 11 books
$1.7 million 270 NHMRC research fellowships Postgraduate students more than $1.7 million in fellowships awarded to there were 270 postgraduate students undertaking research researchers at MHTP at Southern Health or with one of the MHTP partners
4 Southern Health Research Report 2010 5 REDUCING DISABILITY IN CHILDREN WITH CEREBRAL PALSY
Dakota
A bright and vibrant six year old, Dakota has overcome many challenges since her premature birth at 28 weeks. As a newborn she was diagnosed with cerebral palsy, with her right arm and leg affected. Dakota began taking part in a clinical trial being conducted by Dr Brian Hoare from two years of age. Her tenacity and determination together with her family’s commitment to the treatment and therapy regime have seen significant improvement in her dexterity, fine motor skills and strength. Dakota recently began jazz ballet lessons which would have been impossible without this innovative research.
6 Southern Health Research Report 2010 7 The Victorian Paediatric Rehabilitation Service was established at Monash Children’s Clayton in 2007. The service aims to provide all Victorian children who require specialist rehabilitation with the services they need, when they need them. The service is particularly beneficial to children with cerebral palsy who typically require a variety of medical and allied health interventions in a team-focused environment.
Dr Brian Hoare is a senior occupational injections of Botulinum toxin-A and were therapist who provides specialist care randomised to receive one of two post- fast facts to children and adolescents who require injection occupational therapy interventions. rehabilitation after an illness or injury or Cerebral palsy is the most common 1 following a medical intervention such as physical disability in childhood . Botulinum toxin-A (Botox®) injections. Dr Hoare’s trial aimed at not only There is high level evidence that A graduate of La Trobe University, he has reducing the child’s muscle tightness Botulinum toxin-A (Botox®) is effective focused his research on improving the but on improving the ability of children in reducing muscle tightness in effectiveness of upper limb treatments to independently perform daily activities children with cerebral palsy 2. available to children with cerebral palsy. using two hands. Monash Children’s based at Monash Medical Centre Botulinum toxin-A should not be used These children have varying movement Clayton is the first centre in Australia in isolation but should be accompanied disorders caused by disruptions in the 2. to conduct such a trial and the results by planned occupational therapy . way the brain communicates with muscles. have been outstanding. This can have a significant impact Sustained improvement in upper limb on the child’s physical development, bimanual performance can be achieved using either a uni-manual or bimanual independence and quality of life. Without In 2008, Dr Hoare was awarded a approach to training following upper intervention, these children often avoid Department of Human Services ‘Victorian limb injection of Botulinum toxin-A 3. using their affected arm and the muscles Pathways Home Scholarship’ to present become increasingly weaker and tighter, his research at the European Academy of references creating a downward spiral during which Childhood Disability Conference in Croatia. the arm is used less and less. He completed his PhD in 2010 at La Trobe 1: www.cpresearch.org.au University. Dr Hoare’s future research Dr Hoare works alongside Associate focus is on the provision of very early 2: Hoare BJ, Wallen MA, Imms C, Villanueva E, Professor Barry Rawicki, Medical Director Rawicki HB, Carey L. Botulinum toxin A as occupational therapy intervention in infants of the Victorian Paediatric Rehabilitation an adjunct to treatment in the management diagnosed with cerebral palsy. of the upper limb in children with spastic Service and an Australian pioneer in cerebral palsy: An update. Cochrane the use of Botulinum toxin-A in children There is emerging evidence that Database of Systematic Reviews. 2010;Issue 1. with cerebral palsy. Dr Hoare began a intervention provided before brain circuitry 3: Hoare BJ, Imms C, Rawicki HB, Carey L. clinical trial in 2003 to establish the most has been established may avert secondary Upper limb therapy following Botulinum effective combination of upper limb complications and lead to greater success toxin-A in young children with hemiplegic treatments for children with cerebral palsy. in preventing upper limb disability in cerebral palsy: Impact on bimanual Participants in the trial, received upper limb children with cerebral palsy. performance. Developmental Medicine and Child Neurology. Submitted.
Facing page: Dakota Dileo with mother Charelle. This page: Dr Brian Hoare (left) with Associate Professor Barry Rawicki in the Victorian Paediatric Rehabilitation Service at Monash Medical Centre Clayton.
6 Southern Health Research Report 2010 7 CANCER PROGNOSIS INDICATOR BREAKTHROUGH
Bernard
After an ulcer on his tongue failed to heal, Bernard saw his local doctor which resulted in a whirlwind of activity. At the Head and Neck Department, Monash Medical Centre Moorabbin a biopsy was taken and the results confirmed a malignant tumour. Within two weeks treatment began, and a further operation removed the tumour and nearby lymph nodes. Surgery was followed by a course of radiation and chemotherapy.
Bernard was happy to donate the tissue from his tumour to the Victorian Cancer Biobank, saying: “If my experience can go on to help others, I am delighted to take part.” Thanking the doctors, nurses and speech pathologists at Southern Health, Bernard has now fully recovered.
8 Southern Health Research Report 2010 9 Dr Elizabeth Sigston was the successful recipient of a $350,000 cancer research fellowship from the Victorian Cancer Agency in 2010. The fellowship will enable the continuation of vital research into the development of a cancer biomarker.
A protein called Laminin γ2 is found at higher levels in patients with certain In order to undertake the scientific fast facts cancers, including head and neck cancer component of her research, Dr Sigston and it is found on the leading edge of the is collaborating with scientists at several About 2750 people are diagnosed tumours. Dr Sigston’s groundbreaking institutes including the Monash Institute with head and neck cancer each year 1 research is the first of its kind in Australia. of Medical Research and the Monash in Australia . The development of a biomarker could Cancer Centre. The initial background Head and neck cancer can involve any lead to a more accurate prognostic work, including the development of part of the mouth, nose or throat so indicator; it may also help to determine the antibodies, has been supported by a can affect eating, breathing and speech. initial level of treatment a patient requires Project Grant from the Garnett Passe and If treated early, the impact on these and assist pathologists in assessing Rodney Williams Memorial Foundation. daily functions may be minimal 2. resection margins. Whilst smoking is a risk factor, it is Dr Sigston is a surgeon in the Significant effort has been placed into the important to remember that head and Otorhinolaryngology Head and Neck development of systems and processes neck cancer can affect non smokers, department at Monash Medical Centre to ensure the collection of tissue samples like Bernard, and is probably growing Moorabbin which is one of the largest from patients using the Victorian Cancer in incidence 3. head and neck cancer departments in Biobank (VCB). Approximately 70-80% of Australia. She is the Director of Clinical all head and neck patients at Southern Services, Training and Research with Health agree to have their tumours and references the department. serum samples collected by the VCB. It is 1: www.cancer.org.au/aboutcancer Dr Sigston completed her sub-specialty a not-for-profit consortium of tissue banks 2: www.cancervic.org.au/about-cancer surgical training at the Hôpital Européen supported by the Cancer Council Victoria Georges Pompidou in France where and the Victorian Government that aims to 3: www.headandneckoncology.org/ content/2/1/24 benchtop research is integrated with clinical provide researchers with access to high teaching. Following her return to Australia quality tissue samples and data in order to in 2006, she developed an increased facilitate cancer research discoveries that interest in translational cancer research. lead to improvements in cancer diagnosis She commenced a Master of Surgery in and treatment. This is the source of Dr 2006, evolving into a PhD in 2007 that is Sigston’s tissue samples for her research. due for completion in 2012. Her work is Dr Sigston’s focus over the coming years is truly ground-breaking as she is one of to assist the Head and Neck Department in only a few surgeons actively looking at the developing its potential of being recognised translational effect of research into head as a high quality academic department with and neck cancer. a primary focus on translational research.
Facing page: Bernard Mariadas with cancer support nurse James Hardie. This page: Dr Elizabeth Sigston (left) discusses a case with Ear Nose and Throat Registrar Dr Natalie Sist.
8 Southern Health Research Report 2010 9 IMPROVING DIALYSIS TREATMENT
Lynne
Lynne Payne’s vivacious personality and can-do attitude has enabled her to take her regular dialysis sessions in her stride. Lynne has polycystic kidney disease and using her own experience, has helped many new dialysis patients feel less anxious about the choices they need to make. The keen cook and mother of two has spoken about the advantages of fistulas in the arm, a procedure with long-term benefits, at several of the educational days organised by the Nephrology Department. Lynne strongly advocates that patients should actively manage their own care and, where possible, prepare for dialysis through the creation of a fistula.
10 Southern Health Research Report 2010 11 Chronic kidney disease is a significant and growing public health problem. The most recent data from the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry shows a total of 10,341 people were receiving dialysis at the end of 2009.
Professor Peter Kerr was previously a long-term outcomes and lower mortality coordinator for the collection of dialysis rates compared to other approaches to fast facts data for the ANZDATA registry for more blood access for dialysis. than a decade. He now has moved on There are over 10,000 patients on to manage the Australian arm of DOPPS dialysis in Australia; with over 2000 (Dialysis Outcomes and Practice Patterns This research trial translated into new patients commencing dialysis Study). This is a continuous study raising the number of patients having each year. Approximately three quarters 1 collecting data on haemodialysis patients’ fistulas prepared. Additionally the of these start on Haemodialysis . treatments and outcomes from twelve introduction of a patient passport Haemodialysis relies on access to countries worldwide. booklet titled Organising your access the blood – the best way being the to treatment for your kidney failure sets Professor Kerr is the Director of Nephrology establishment of a fistula in the out what type of treatments are available arm, yet less than half of Australian at Southern Health. After undertaking his and how to access them. The passport patients actually start dialysis with an graduate training at the old Prince Henry’s also allows the patient and the treating established fistula 2. Hospital in Victoria including a PhD in team to have an ongoing reference of transplant immunology, Professor Kerr took treatment decisions. Overcoming this barrier is important the opportunity to work overseas at the as patient survival is significantly Hôpital Lapeyronie (Montpellier) in France. better if patients commence dialysis It was during this time that he developed 2-3 Professor Kerr also plans to research with an established fistula . a keen interest in dialysis related renal phosphate control in dialysis patients. research, completing ten research papers Patient, nurse and doctor education Currently many patients find it difficult to in a year and returning to Australia with a are all important aspects of improving comply with medication guidelines and solid understanding of dialysis. the rates of fistula creation 3. higher phosphate levels are associated In 2010, Professor Kerr together with with increased mortality for the patient. references Associate Professor Kevan Polkinghorne, Jointly Professor Kerr and Associate focused on a trial to overcome the barriers Professor Polkinghorne and their team are 1: ANZDATA Registry: www.anzdata.org.au for using fistulas in dialysis patients. A working on a variety of dialysis research 2: Polkinghorne KR, McDonald SP, Atkins fistula is produced when a vein and an projects. Another member of the team, RC, Kerr PG. Vascular access and all cause artery in the arm or leg are joined together Associate Professor John Kanellis heads mortality: a propensity score analysis. so that blood can move in and out of the J Am Soc Nephrol 2004; 15(2):477-86. up the kidney transplant research team, body more quickly during dialysis. This is with Monash Medical Centre Clayton being 3: Polkinghorne KR, Seneviratne M, Kerr PG. the method eventually used in 85% of only one of two sites in Australia providing Reducing central venous catheter use in patients at Southern Health. The procedure incident haemodialysis patients: the effect combined kidney-pancreas transplantation can be daunting for new patients, but the of the vascular access nurse coordinator. for type 1 diabetics. Am J Kidney Dis 2009; 53(1):99-106. use of a fistula is associated with improved
Facing page: Lynne Payne. This page: Professor Peter Kerr (left) with Associate Professor Kevan Polkinghorne and Mechelle Seneviratne, Vascular Access Nurse for Nephrology.
10 Southern Health Research Report 2010 11 LEADING THE WAY IN EMERGENCY CARE
Ryder
Ryder was just 28 days old when he was diagnosed with bronchiolitis in the Emergency Department at Monash Medical Centre Clayton. As a mum of three boys Kelly had been through this before with Ryder’s brother and she knew how quickly the condition could deteriorate in infants. She agreed that Ryder could take part in the clinical trial being conducted, saying “without a trial it is impossible for other children to receive the best possible care in the future”. Ryder was given an intravenous line to maintain his hydration levels and after a short stay in hospital he was back at home. He is now a happy and healthy ten month old who loves to play with his older brothers.
12 Southern Health Research Report 2010 13 Bronchiolitis is a chest infection of the small tubes in the lung and causes babies and infants to cough and wheeze. It most often happens around the beginning of winter and can lead to serious illness. Babies may cough so much and have such difficulty breathing that it is hard for them to drink and they become dehydrated very quickly. Re-hydration treatment involves either the use of an intravenous line or a nasogastric tube to enable the infant to receive fluids.
Associate Professor Ed Oakley, Director Associate Professor Oakley and his of Paediatric Emergency at Southern team have also investigated the use fast facts Health, initiated a trial to compare which of ultrasound to assist with the insertion method of hydration most improved of a drip into a child’s arm. They have Bronchiolitis is the leading cause of the treatment outcome of children successfully demonstrated that the hospitalisation during the first year of life and 1-3 suffering from bronchiolitis. The trial use of an ultrasound can increase the is a major cause of morbidity and mortality . was randomised with 50% of patients speed and accuracy of performing Each year there are over 200 children admitted receiving an intravenous line and 50% this often difficult procedure. to Southern Health hospitals with bronchiolitis. receiving a nasogastric tube. This three Dr Diana Egerton-Warburton is the year international trial will be completed The estimated cost of the Victorian Director of Emergency Medicine in 2011; the research was made bronchiolitis hospital admissions for 2006 is Research at Monash Medical Centre possible by an $860,000 research grant $8.1 million dollars 4. from the National Health and Medical Clayton and her research interests Research Council (NHMRC). include anti-emetics, an important The trial on bronchiolitis re-hydration is being area in emergency medicine. Her team performed throughout the Paediatric Research An economic analysis of the cost of has recently completed a randomised in Emergency Departments International this disease to the Australian economy controlled clinical trial of 200 patients Collaborative 5. using the trial data will be completed to investigate the use of anti-nausea in collaboration with Deakin University. medication side effects in patients who references The trial is being conducted across present to the emergency department. seven hospital emergency departments Currently 80% of emergency medicine 1: Leader S, Kolhase K. Recent trends in severe respiratory across Australia and New Zealand. physicians prescribe metoclopramide, syncytial virus (RSV) among US infants, 1997-2000. which can cause the side effect of J Pediatr. 2003; 143(5 suppl): s127-s32. restlessness and Dr Egerton-Warburton 2: Pelletier AJ, Mansbach JM, Camargo CA, Jr. Direct In 2010, Associate Professor is exploring how metoclopramide and Medical Costs of Bronchiolitis Hospitalizations in the Oakley also published an article ondansetron compare to placebo. United States. Pediatrics. 2006; 118: 2418-23. demonstrating that the current 3: Shay DK. Bronchiolitis-associated hospitalisations among antidote for paracetamol poisoning This follows a journal review before the US children, 1980-1996. JAMA. 1999; 282: 1440-6. can be administered to children trial began that suggested the use of 4: Data from Victorian Admitted Episodes Dataset, a placebo was just as beneficial. It is with relative ease when compared Performance Reporting & Analysis Unit, Department of to current practice methods. He hoped the study results will change Human Services Victoria. current practice internationally. The trial expects this research will be used to 5: Babl FE, Borland M, Ngo PK, Acworth J, Krieser D, Pandit team is funded by a Morrison Taylor create evidence-based, best-practice S, et al. Paediatric research in emergency departments procedures across all emergency Award and a Southern Health Emerging international collaborative (predict). J Paediatr Child departments treating children. Researcher Fellowship and will be Health. 2005; 41(11): 614-5. completed in 2011.
Facing page: Ryder with his mother, Kelly Waddington. This page: Associate Professor Ed Oakley (right) and Dr Diana Egerton-Warburton in the Emergency Department, Monash Medical Centre, Clayton.
12 Southern Health Research Report 2010 13 2010 EMERGING RESEARCHER FELLOWS
Ms Alicia James Dr Kathy Low Ms Laura Tirlea
2010 was an extraordinary year for Ms As a child Dr Kathy Low witnessed her Ms Laura Tirlea has been a Youth Health Alicia James who received an Emerging brothers’ severe asthma attacks and Worker at the Greater Dandenong Researcher Fellowship and the Jennifer made the decision to study medicine. Community Health Centre for the O’Mere Award. The Jennifer O’Mere Academically she excelled and secured past nine years; she completed her Award is given to young podiatrists who a Government and Monash Merit and Postgraduate Diploma of Psychology at have made an outstanding contribution in Equity Scholarship to begin medicine at Swinburne University in 2007 and has the first five years of practice. Monash University. Dr Low now works always had a strong desire to focus as a Respiratory Research Registrar and Since graduating from La Trobe University on research within her career. She is believes that research is vital to eventually passionate about improving the welfare in 2006 Ms James has focused on finding a cure for asthma and to of children and adolescents through working with children at Cardinia determine the best methods of treatment their social and wellbeing development. Casey Community Health Service. She and ongoing care for asthmatics. particularly enjoys regular contact with The Emerging Researcher Fellowship During her work with Professor Philip the children and the ability to review the has enabled Ms Tirlea to concentrate on Bardin she co-authored an article which progress of each patient. evaluating the “Girls on the Go!” program was published in ‘Respirology’ (2009), which the youth team from the Greater Completing a Masters of Health Science which discussed the ground-breaking Dandenong Community Health Services (Podiatry) gave Ms James the confidence use of a 320-slice dynamic volume developed eight years ago. The program to begin integrating research into her computer tomography machine to targets young women who have a range career; the Emerging Researcher obtain explicit images of vocal cord of health issues such as low self esteem Fellowship has enabled her to investigate dysfunction. Vocal cord dysfunction is a and confidence, negative body image the effectiveness of commonly used condition which may mimic asthma and and disordered eating patterns, weight treatment approaches for heel pain involves abnormal closure of the vocal issues and eating disorders. The “Girls in children. Ms James describes the cords. Given the breadth of research on the Go!” program encourages healthy fellowship as a fantastic opportunity to required to understand the relationship eating, participation in physical activity, reduce her clinical load in order to obtain between vocal cord dysfunction and improving self esteem and confidence, extra time for research. She credits the asthma, Professor Bardin encouraged improving body image, connection and experience gained during her fellowship Dr Low to apply for the Emerging participation in the community and small for giving her the confidence to apply Researcher Fellowship. She has relished but permanent changes to lifestyle. for and successfully obtain acting team the opportunity to concentrate on her leader role within her department. research and is delighted that her clinical The young women who take part in Ms James is continuing to collect data research still allows her to spend time the program are identified by teachers for her Fellowship after deciding to with patients. She plans to turn her and youth workers within local primary take the project further and use the fellowship project into a PhD. and secondary schools. Ms Tirlea information to start on her PhD which contacts the young women after they Dr Low played an integral part in setting she hopes to complete by 2014. have completed “Girls on the Go!” to up the Laryngeal Dysfunction clinic in determine if the program is still having a Aside from her clinical role, Ms James 2010; the clinic takes a multi-disciplinary positive effect. She is confident that her is a director of the Australian Podiatry approach to the treatment of asthma evaluation of the program will identify the Association for Victoria and in 2009 and vocal cord dysfunction. Patients aspects of the therapeutic work which she co-convened the ‘Paediatrics in are treated by a team of practitioners are beneficial and also the elements Practice’ Conference which attracted including doctors and speech which could be improved. After collating over 200 allied health practioners. pathologists. Results from the clinic are and analysing the data Ms Tirlea plans to promising with many patients reducing use the information to begin her PhD in their need for medication and being early 2011. able to return to work.
14 Southern Health Research Report 2010 15 A CALMING INFLUENCE ON THE STRESS OF DEMENTIA
Dementia is a chronic, progressive mental condition that reduces people’s ability to remember recent events, make decisions and complete everyday tasks. It is often complicated by depression, psychosis and challenging behaviours that reduce sufferers’ quality of life and make caring for them more stressful. There is still no definitive treatment for Alzheimer’s disease, the commonest cause of dementia in older age-groups, and so a support network of family, friends and carers is vital for those diagnosed with the condition.
Professor Daniel O’Connor (centre) with members of his team at the Aged Mental Health Research Unit.
Over the course of his career Professor oil massaged into the forearm can reduce problem which greatly reduces residents’ Daniel O’Connor has researched agitated behaviours. Lavender has positive quality of life but receives much less techniques and methods to alleviate stress effects in animal models but has yet to attention than agitated behaviours. and improve care for elderly people with be tested definitively in clinical trials. dementia, depression and other mental The results will be known later this year. disorders, particularly those living in nursing Previous trials of antidepressant In the second NHMRC study, earlier work homes. After completing his psychiatry medications had disappointing by the team showing that activity programs training in Auckland, New Zealand, results but, in a large trial funded work best when adapted to people’s Professor O’Connor accepted a role by beyondblue, a combination of earlier interests and skills is being pursued as a research fellow at Cambridge medication with simple psychosocial using Montessori educational principles. University in the UK. During this time he approaches implemented by staff led The activities are inexpensive, require investigated the prevalence of dementia to a significant improvement in mood. in the community and residential facilities little training and do not require the use and tested the effectiveness of early of language, a powerful advantage in people whose language skills have been support services for families. Professor O’Connor credits his team and lost through dementia or who come from the staff at Southern Health’s Allambee One focus of his current research is on non-English speaking backgrounds. So far, Unit and Chestnut Gardens nursing ways to reduce agitated behaviours the results look very promising indeed with homes for their support, without which his in nursing home residents with severe evidence of reduced agitation, heightened clinical trials would not be possible. He dementia. In the first of two studies attention and increased engagement. also collaborates with aged mental health funded by the National Health and services from Frankston, Caulfield and Medical Research Council (NHMRC), Another focus has been on the treatment Geelong hospitals. Professor O’Connor’s team has embarked of depression in nursing home residents upon a trial to discover whether lavender with dementia. Depression is a common
14 Southern Health Research Report 2010 15 RESEARCH GOVERNANCE
The Research Directorate is responsible for implementing Southern Health’s research governance framework and provides comprehensive, practical assistance to researchers. This includes advice on research ethics, budgets, contracts, indemnities, grant applications, mentoring, advocacy and advice for our researchers and study co-ordinators. Southern Health has best practice research governance arrangements. This was confirmed in 2010 with a continued rating of Outstanding Achievement for the Research Standard 2.5 by the Australian Council on Healthcare Standards.
Chief Executive Corporate Counsel
Executive Director of Executive Director Executive Management Nursing and Midwifery Medical Services & Quality Team
Research Advisory Council
Deakin – Southern Health Research Directorate Nursing Research Centre
Southern Two Human Research Week Research Victorian Cancer BioGrid Australia Health Research Ethics Organising Report Editorial BioBank Steering Management Libraries Committees Commitee Committee Committee Committee
Low Risk Review Panel
RESEARCH DIRECTORATE STAFF
Ms Malar Thiagarajan Ms Kathryn Frowen Mrs Micheleine Uhe Director Research Services Project Officer Research Governance Officer (from November) Ms Deborah Dell Ms Julie Carlin Administrative Officer (HREC) Administration and Mrs Heather Jackson Communications Officer Secretary Ms Julie Gephart Administrative Assistant (HREC) Mrs Sara Goodman Research Governance Officer (to September)
16 Southern Health Research Report 2010 17 SUPPORT OUR RESEARCH
Southern Health is Victoria’s most There are many ways to support our integrated health service, providing care research including: across the continuum of life. We pursue Donations Corporate Support an extremely broad range of disease Bequests Trusts in Perpetuity and health care research across all health Deferred Capital professions in collaboration with both local and international research partners. Every dollar donated will directly fund medical research and education at Southern Research conducted at Southern Heath Health and if requested, can be distributed is supported by the generosity of to support areas of specific interest to individuals, businesses and community you. All donations to support research at groups. This financial support allows Southern Health are tax deductible. us to continue making discoveries, For further information, please contact improving technologies and making a the Monash Health Foundation on real difference to clinical care. (03) 9594 2700 or the Research Directorate on (03) 9594 4056.
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16 Southern Health Research Report 2010 17
Monash Health Foundation RESEARCH SERVICES
RESEARCH ADVISORY Research Week 2010 COUNCIL Research Report 2009
The Research Advisory Council (RAC) Draft Research Strategic Plan maintains a key oversight role in the 2010 – 2013 activities of the Research Directorate. The broad role of the council is to develop Monash Health Translation Precinct and guide research strategy and assist Business Case submission to Southern Health to achieve our goal Department of Innovation, Industry to be a health service of international and Regional Development standing in the improvement of health Emerging Researcher Fellowship care. Membership of the council reflects Scheme 2010 the close relationships between Southern Health, Monash and Deakin universities, Outstanding Achievement (OA) for Prince Henry’s Institute and the Monash Research Standard in Mental Health Ms Malar Thiagarajan Institute of Medical Research. and Continuing Care Accreditation Director of Research Services The council had five meetings during 2010 Deakin University – Mutual Acceptance and the following matters were discussed: Ethical Review
Revised Terms of Reference for RAC Monash University Biostatistical Consulting Service Clinician-Researcher Leaders’ Forum Terms of Reference Membership of BioGrid Australia – membership fees Revised Human Research Ethics Committees’ Terms of Reference Membership of Neurosciences Victoria
NHMRC Harmonisation of Clinical Support Time for Public Multi-Centre Ethical Review application Hospital Doctors, Australian Medical for certification Association Position Statement
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Research Governance Toolkit, Victorian Professor Matthew Gillespie HUMAN RESEARCH ETHICS Managed Insurance Authority Prince Henry’s Institute COMMITTEES National Health and Medical Research Dr Terry Haines There are two Human Research Ethics Council (NHMRC) Strategic Plan Southern Health/Monash University Committees (HRECs) at Southern Health. 2010 – 2012 Professor Stephen Holdsworth The committees operate in accordance Draft Conflicts of Interest in Research Southern Health/Southern Clinical School with the National Statement on Ethical Policy Conduct in Human Research (2007). The Professor Paul Martin HRECs meet monthly, except in January, to
Draft Quality Assurance Procedure & Southern Health/Monash University review research applications for proposals Application Form involving patients and staff at Southern Professor Barry McGrath Health. The HRECs are supported by Draft Guidance on Data Safety Southern Health/Monash University Ms Malar Thiagarajan, Director of Monitoring Boards Research Services, Ms Deborah Dell, Professor Graham Meadows NHMRC 2010 Fast Facts Book Administrative Officer, Ms Julie Gephart, Southern Health/Monash University Administrative Assistant and Mrs Heather 2010 Victorian Cancer Agency Grants Jackson, Secretary. Professor Ian Meredith Research Week 2011 Southern Health/Monash University The Chairs of the Human Research Ethics Committees in 2010 were:
NHMRC 2011 funding announcements Professor Beverley O’Connell HREC A Professor Mel Korman, – Program Grants & Centres of Deakin University HREC B Dr Simon Bower, and the Medical Research Excellence Administrators to the HRECs in 2010 Ms Shelly Park were Dr James Doery and Dr Ian Woolley. NHMRC: Institutional Process Certificate Chief Executive, Southern Health The Low Risk Review Panel reviews Monash Children’s development Associate Professor Wayne Ramsey proposals which range from surveys, and Hospital Research Directors Forum – Southern Health data collection studies, through to quality clinical research funding assurance projects which involve minor Professor Julian Smith privacy concerns. Monash Cancer Consortium successful Southern Health/Monash University research funding announcements The Therapeutics Committee, led by Professor Helena Teede Professor Richard Harper, Chair, and Outstanding Achievement (OA) Southern Health/Monash University Mr Ian Larmour, Executive Officer, award for Research Standard during reviews all drug trials and provides Professor Euan Wallace Accreditation by the Australian Council advice to the Committees. of Healthcare Standards Southern Health/Monash University
Professor Steve Wesselingh Research Advisory Council Monash University PROJECTS SUMMARY members 2010 There were approximately 675 research Professor Bryan Williams projects being conducted at Southern Professor John Funder Monash Institute of Medical Research (Chair) Health during 2010. The Southern Professor Barbara Workman Health HRECs and Low Risk Review Ms Cheyne Chalmers Southern Health/Monash University Panel reviewed a total of 190 new ethics Southern Health/Deakin University applications and approved 185 projects. Of those, 22 were Streamlined Ethical Associate Professor Nicholas Freezer Corporate Counsel Review Process (SERP) projects and Southern Health/Monash University Southern Health Corporate Counsel, additionally there were 40 projects which were approved and will be conducted at Professor Peter Fuller Mr John Snowdon and Legal Counsel, Southern Health, however their ethical Prince Henry’s Institute Ms Sue Allen provide legal support as required. reviews were conducted at other health services via the SERP scheme. The graph on page 20 shows the categories of research of the approved projects and within these, there were seven phase one, 21 phase two, 34 phase three and 10 phase four trials.
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New research projects approved in 2010 by category (n=225)
Clinical Drug/ 32 Other 94 Device Trial
2 Public Health
Social or 7 Health Science
18 Psychological
72 Clinical Research
Figure 1: The number of new research projects approved by the Southern Health HRECs in 2010 by category of research.
New research projects approved over 7 years by category (n=1,490)
120
100
80
60
40 Number of projects 20
0 2004 2005 2006 2007 2008 2009 2010
Clinical Drug/ Clinical Research Psychological Social or Public Health Other Device Trial Health Science
Figure 2: The number of new research projects approved by Southern Health HRECs by research category from 2004 – 2010.
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Certification of the Quality assurance applications Southern Health and Monash University Southern Health HRECs to assist researchers to conduct There were 134 quality assurance health-service based research by the National Health and proposals received during 2010. In Medical Research Council accordance with the NHMRC guidelines, Monash Children’s Cancer Centre the scope of the activities considered to at Southern Health and the Royal The Southern Health HRECs in September be a quality assurance activity are defined Children’s Hospital Children’s Cancer 2010 received Certification by the National as all the various activities designed to Centre for Children’s Oncology Health and Medical Research Council in evaluate, monitor and improve the quality Group studies accordance with the National Certification of health services. Scheme for its institutional processes Southern Health and Cancer Trials relating to the ethical review of multi-centre Australia for clinical trials facilitated research. Southern Health’s HRECs have Research governance audits by Cancer Trials Australia been certified to provide ethical review In 2010, Research Governance Officer, Southern Health and Deakin University for multi-centre research in the following Ms Sara Goodman, conducted ten to assist researchers to conduct categories of research: random audits of current research projects. This involved reviewing the study health-service based research. Clinical Trials Phase 1 documentation, the data management and compliance with the applicable HREC Human Research Ethics Clinical Trials Phase II requirements and all relevant regulations, Committee A members Clinical Trials Phase III including NHMRC guidelines. The audits Professor Mel Korman highlighted seven of those research teams Chair Clinical Trials Phase IV had no compliance issues with good clinical research practice guidelines and Dr James Doery Paediatric Research maintained sound research practices. Health Care Professional The three other teams had minor issues Clinical Interventional Research other requiring advice. Ms Elizabeth Gillespie than Clinical Trials Health Care Professional
Population Health/ and or Public Health Biostatistics support Mr Doug Gimesy Layman Mental Health Biostatisticians of the Monash University School of Public Health and Preventive Dr Peter Kempster The period of Certification is valid between Medicine review many research proposals Health Care Professional 01 January 2011 to 31 December 2013. for the HRECs. This biostatistics review is in accordance with the National Statement Ms Margaret Kingston Streamlined Ethical Review requirements to ensure that the sample Lawyer size is adequate to demonstrate both Process clinically and statistically significant effect. Ms Helen Kopp The HREC’s were accredited in 2009 This expert support, provided by Associate Health Care Professional by the Consultative Council for Human Professor Damien Jolley and Mr Eldho Mr Ian Larmour Research Ethics of the Department of Paul was invaluable in maintaining a high Health Care Professional Health (Victoria) for the Streamlined Ethical standard of ethical review of all research conducted at Southern Health during Review Process of multi-site clinical trials in Ms Francine Lyn the year. Victoria. The initiative operated throughout Health Care Professional 2010 and streamlined the ethical review for commercially sponsored multi-site trials. Mutual Acceptance Programs Reverend Tony Poole Southern Health reviewed 22 proposals (MAP) Minister of Religion for multi-centre clinical research on behalf Ms Helen Stubbs of a number of Victorian institutions. Southern Health has established Mutual Acceptance Programs for Human Laywoman Southern Health accepted the review of Research Ethics Review in accordance with other accredited institutions in Victoria Ms Bobbee Terrill the NHMRC National Statement on Ethical who reviewed 41 projects that involved Health Care Professional Conduct in Human Research (2007). The researchers at Southern Health. statement advises that institutions that Associate Professor Krishna Vaddadi regularly have review responsibilities for the Medical Researcher same research should agree on a single review body to review the research. The Associate Professor Kumar Visvanathan establishment of the following agreements Medical Researcher helps avoid any duplication in review:
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Ms Janne Williams Low Risk Review Panel Ms Wendy Ewing Health Care Professional members QUM Pharmacist Dr Ian Woolley Ms Denise Brookes Dr Mark Fajgman Medical Researcher Health Care Professional Anaesthetics
Professor Ben Canny Dr Dimitri Giannios Human Research Ethics Medical Researcher Emergency Medicine Committee B members Dr Damien Castanelli Dr Victor Gordon Dr Simon Bower Health Care Professional Neurosciences Chair Professor David Clarke Associate Professor Kate Jackson Dr Steve Alatakis Health Care Professional Palliative Care Medical Researcher Dr Diana Egerton-Warburton Associate Professor Terrence Johns Dr Pascal Bernard Medical Researcher Centre for Cancer Research, MIMR Medical Researcher Ms Maggie Emmerton Ms Elaine Kennedy Dr Justin Brown Health Care Professional Nursing Representative Health Care Professional Ms Nicole Fairweather Mr Robin Lee Dr Beverley Castleman Health Care Professional Pharmacy at Casey Laywoman Ms Joanne Mockler Dr Heath Liddell Dr Bev Copnell Health Care Professional General Medical Representative Medical Researcher Ms Laima Muceniekas Mr Allan Manser Professor Wendy Cross Health Care Professional Pharmacy at Monash Medical Centre Medical Researcher Dr Anna Murphy Dr Andrew Martin Mr Trent Curtain Medical Researcher General Medical Representative Layman Associate Professor Brendan Murphy Dr Geoff Matthews Dr James Doery Medical Researcher External representative Health Care Professional Dr Nigel Toussaint Ms Angela Melder Dr Terry Haines Medical Researcher Clinical Effectiveness Medical Researcher Dr Alex Padiglione Mr Allan Manser Therapeutics Committee Infectious diseases and Clinical Health Care Professional members Epidemiology Ms Alison Medhurst Prof Richard Harper Ms Silvana Pignataro Health Care Professional Chair QUM Pharmacist Dr Bill Mulley Mr Ian Larmour Dr Hang Quach Medical Researcher Executive Officer Clinical Haematology Mr Bernard O’Shea Dr Peter Briggs Dr Boyd Strauss Lawyer General Medicine Program Clinical Nutrition Associate Professor Christine Rodda Professor George Braitberg Ms Marianne Wadsley Health Care Professional Emergency Medicine General Medical Representative Dr Stephen Tong Dr Anjali Dhulia Dr Amanda Walker Medical Researcher Medical Administration Paediatrics Ms Claire Vosk Ms Maggie Emmerton Dr Leeroy William Health Care Professional Pharmacy at Dandenong and Palliative Care Father Albert Yogarajah Kingston Centre Dr Norman Zimmerman Minister of Religion Mental Health Program
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SOUTHERN HEALTH RESEARCH WEEK 2010
Inflammatory & Infectious Diseases Winner IF5 Saleela Ruwanpura IF9 Belinda Thomas
Highly Commended IF11 Sebastian Stifter IF14 Melanie Hutton IF15 Cody Allison
Dr Norman Swan with the panellists from the hypothetical Endocrinology & Metabolism, Left to right - Dr Andre Vanzyl, Prof Stephen Stuckey, Dr James Burnes, Endocrinology & Men’s Health Mr Alan Saunder, A/Prof Richard King Front row - Mr Raymond Tiernan, Ms Shannon Montey, Prof Grant Russell, Winner Dr Norman Swan EM7 Tracey Quinn
Highly Commended In collaboration with our many university The poster competition continued EH5 Peter Nicholls and institute partners, Southern Health its popularity from previous years. EM2 Lisa J Moran hosted its annual research week from The standard of posters this year 10 – 14 May 2010. Prof Ed Byrne, was outstanding throughout the eight Mental Health & Neuroscience Vice-chancellor of Monash University categories. Over 160 entries were opened the week with a keynote received with winners in each category Winner receiving a $250 prize, a number of address that discussed the importance MN5 Tamara Yawno highly commended prizes were also of “Academic Health Precincts”. In his given in each area as follows: presentation Prof Byrne discussed some Highly Commended of the reasons for enhancing health Eclectic / Co-morbidities MN9 Louise Corben provider university collaborations and MN10 Graham Meadows for even closer interactions in the future Winner MN15 Velandai Srikanth that have applied in the past. Prof Byrne CM1 Janine Engstrom also discussed academic health science Neonatal & Women’s Health centre models as recently developed Highly Commended in the United Kingdom and possible EC9 Kylie Way Winner applicability to the Australian scene. EC16 Karen Salamon NW6 Flora Wong NW17 Ellen Menkhorst The Senior Medical Staff symposia Paediatrics focused on Diagnostic Imaging. Dr Highly Commended Norman Swan, a multi-award winning Winner NW7 Natalie Hannan broadcaster and journalist led a Diagnostic PD 21 Stephanie Yiallourou NW15 Cheryce Harrison Imaging hypothetical titled ‘The imaging NW31 YukShan Kong conveyor belt’ which reflected on demand, Highly Commended usuage and cost-benefits of contemporary PD3 Gill Nixon diagnostic imaging. The event proved to PD26 Simon Wilkins Cardiovascular Disease be thought provoking and entertaining. Winner Cancer ‘The Great Debate’, a battle of the sexes CV8 Amanda Rickard between six prominent staff members, Winner on the topic “The more we learn, the less CC10 Nicholas Fleming Highly Commended we know” was a great success. Several CV2 Tamica Hoggins seminars hosted by Allied Health were Highly Commended CV4 Lauren Sanders co-oridnated and hosted at the same time CC2 Sarah To CV5 Joshua Casan across several Southern Health sites. CC6 Dhanya Sreedharan
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Ageing: Monash Ageing Research Centre (MONARC)
DIRECTOR: PROFESSOR BARBARA WORKMAN
Monash Ageing Research MONARC appointed a manager to support Southern Health has the largest number Centre development of research expertise and of positions for trainee geriatricians in dissemination of research results through Victoria and new training positions in MONARC is a research centre within regular seminars, support to researchers expanded settings have commenced. the Faculty of Medicine, Nursing and through improved strategic planning and Health Sciences, Monash University improved access to external funding based at Southern Health. A significant opportunities and promotion of MONARC. Aged Mental Health number of the researchers also provide Research Unit a clinical service to Southern Health so The unit is also part of the School of the results of research can be readily Academic Unit of Geriatric Psychology, Psychiatry and Psychological translated into practice. During 2010, Medicine Medicine and is based at Kingston Centre. MONARC became aligned with Monash The unit continues to focus on clinical Staff members include psychiatrists University’s School of Public Health and research in geriatric medicine and and psychologists with expertise in the Preventive Medicine due to a restructure there was successful recruitment of assessment, diagnosis and treatment within the University. This has facilitated two geriatricians, both qualified in of late-life mental disorders. Research development of additional collaborations epidemiology, who bring interests in interests include depression in residential and a new stream of research developing quality, dementia, patient safety and care, electroconvulsive therapy (ECT) in epidemiology and ageing. medication to the unit. and challenging behaviours in dementia. Staff contribute to undergraduate and Ongoing work in health services reform postgraduate teaching of a range and medical education continue, and the of disciplines at Monash and other unit staff contribute to the undergraduate universities. MBBS teaching program in all years of the course with a significant contribution to Year 5/D.
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Clinical Research Centre for Rehabilitation RESEARCH ACTIVITIES Movement Disorders and Gait The Acute Rehabilitation Program in This centre investigates neurological Southern Health focuses on the provision The Aged Mental Health conditions across the age continuum, with of inpatient and ambulatory rehabilitation Research Unit particular reference to basal ganglia and to adults with a wide range of impairments cerebellar disorders such as Parkinson resulting in disabilities. These include The Aged Mental Health Research disease and autism. In 2010, the centre neurological disorders such as stroke and Unit is a partner of the Commonwealth concentrated on finalising several subarachnoid haemorrhage; orthopaedic Government’s Dementia Collaborative projects, resulting in a number of journal issues such as joint arthroplasty or lower Research Centre with the goal of identifying papers being prepared for submission limb fracture as well as severe debility non-pharmacological treatments of the with publication expected in 2011. Staff following medical or surgical problems. behavioural and psychological symptoms also concentrated on grant applications There are also a number of specialty areas of dementia and then mounting trials of throughout the year, resulting in several such as spasticity management, chronic their efficacy. Seeding grants from the new projects commencing in 2011, with a pain and Friedreich’s ataxia. The research Dementia Collaborative Research number of applications still outstanding. activities of the program involve projects Centre led to two successful NHMRC based around the clinical expertise and grants for randomised controlled trials of The centre has a dedicated research experience of the unit. lavender essential oil and personalised, staff allocation, but also accommodates goal-directed activities as treatments project staff, postgraduate doctorate and of agitated behaviours in nursing home honours students, and Southern Health Research achievements residents with dementia. Both studies will clinical staff participating in research for 2010 come to an end late 2011. or evaluating rehabilitation outcomes. An invitation was extended to Professor The unit recently completed a successful Collaborations and formal links with Workman to present in China on Geriatric randomised controlled trial funded by Monash University, the University of Rehabilitation. It is hoped this may lead to beyondblue of multi-disciplinary treatments Melbourne, the Murdoch Institute, the further research collaborations in China on of major depression in nursing home Alfred Hospital and Caulfield General health service development and medical residents with dementia. A combination of Medical Centre enable an expansive education and training. network of experts from multiple fields health evaluations, pleasant activities and to work together on a wide variety of Professor O’Connor contributed a adjustment of antidepressant medications research projects. chapter to the world’s leading textbook resulted in a significant lifting of mood. on dementia and also to the International This is encouraging as previous research The centre’s facilities include the Gait Psychogeriatric Association’s guidelines had suggested that depression in people Laboratory, with a three-dimensional on the treatment of the behavioural and with dementia was resistant to commonly motion analysis system, force platforms, a psychological symptoms of dementia. used therapies. The next step will be to computerised walkway, electromyography explore the practical, professional and and electroencephalogram equipment and The unit attracted two very promising structural barriers to implementing such the recently installed remote controlled young geriatric medicine researchers who treatments in everyday practice. split screen video system that tracks with have trained at Harvard. the individual as they walk through the In another study, it was confirmed that laboratory. The Clinical Research Centre for Movement nursing home residents with dementia Disorders and Gait received $US180,000 who come from culturally and linguistically Closely aligned to the centre is the grant funding from the National Parkinson diverse backgrounds communicate Clinical Gait Analysis Service that was Foundation (USA). more with co-residents and staff when established late in 2004. This part-time they live in ethno-specific, as opposed diagnostic service provides detailed Four senior members of staff presented to generic, residential facilities. They information relating to an individual’s at the 3rd International Congress on Gait were also prescribed fewer psychiatric walking pattern to assist in treatment and Mental Function, Washington DC and medications, pointing to lower levels of decision-making in people with a two senior members of staff presented behavioural disturbance. These findings neurological disorder affecting their at the 2nd World Parkinson Congress, have significant policy implications given gait. It is the only adult clinical service Glasgow, Scotland. the rapidly growing numbers of older in Australia and with an expanding Australians from non-English speaking database of patients, has immense backgrounds. To pursue this topic in more potential to translate clinical findings detail, we now have a grant from the Lions into evidence based practice. John Cockayne Memorial Fellowship Trust Fund to conduct a survey of the match between languages spoken by staff and residents of local aged care facilities.
24 Southern Health Research Report 2010 25 RESEARCH GROUP REPORTS Ageing: Monash Ageing Research Centre (MONARC)
It is also hoped to recruit volunteers to This project has identified that although Normal Walking Patterns of Adults implement individualised activities that residents in aged care facilities are aware in Victoria. Investigators: Dr Anna require little or no shared language for of deaths in co-residents, this has little Murphy, Ms Dianne Cameron, Ms Mary cognitively impaired non-English speaking impact on their mental health. Grief and Danoudis and Prof Robert Iansek, residents who would otherwise be bereavement issues are more likely to be CRCMD&G, Southern Health; A/Prof excluded from such programs. due to loss of independence and previous Barry Rawicki, Clinical Gait Analysis lifestyle. An education package for staff of Service, Southern Health. Benefits: It is known from previous research that residential facilities will be developed and This project will lead to the development the family carers of people with dementia trialled to assist staff in managing issues of a database of normal walking often continue to experience high levels of of grief amongst residents. patterns of adults in Victoria across a stress when their relative enters residential range of age groups. The database care. In an attempt to reduce this stress, will be utilised by both the CRCMD&G and to improve their quality of life, the unit CLINICAL RESEARCH and the Clinical Gait Analysis Service received funding from the Wicking Trust to to compare the walking of people undertake a randomised controlled trial of CENTRE FOR MOVEMENT with and without disability to assist in support groups for the spouses of nursing DISORDERS AND GAIT understanding how and why differences home residents with dementia. The study in walking occur in people with a is near completion and the results look Completed projects particular diagnosis. promising. Most spouses were keen to
participate and found the experience The effect of fatigue on attentional A systematic investigation of normal highly beneficial. resources required for the postural gait: What can the spatiotemporal stability of older people. Investigators: parameters of walking tell us about Researchers in the unit also have an Dr Thorlene Egerton, CRCMD&G, central control of gait and the impact interest in electroconvulsive therapy Southern Health. Benefits: This project of Parkinson’s disease? Investigators: (ECT), an effective treatment for severe aimed to test the immediate effect of Prof Robert Iansek, Dr Anna Murphy, depression. The clinical features predictive being both physically and mentally Dr Thorlene Egerton and Ms Mary of a good response to ECT – psychomotor tired on the ability of older people to Danoudis, CRCMD&G, Southern Health; retardation and psychosis – rise in maintain their balance. This information Dr Frances Huxham, Physiotherapy frequency with age, making the treatment may help us to understand why some Consultant, Southern Health. Benefits: especially useful for older people. We older people fall. In addition, this work This study aims to determine whether have shown that ECT use in Victoria is relevant to people with a range stride length is the key control variable has shown little change over the last of diagnoses including Parkinson’s used by the brain to initiate walking. decade, despite the advent of new, better Disease, and may lead to further The results will improve therapy tolerated antidepressant medications, studies in clinical populations. management of neurological conditions suggesting that ECT still has a useful affecting gait. role to play. In the hands of this team, Current projects ECT lifted mood successfully with only Identification of cerebral electrical minor cognitive sequelae. It also proved Deep Brain Stimulation in Patients potentials and wave forms in the highly successful in cutting re-admissions with Advanced Parkinson’s Disease. control of gait. Investigators: to hospital when administered on an Investigators: Prof Robert Iansek, Prof Robert Iansek, Dr Anna Murphy outpatient basis to patients at very high Ms Dianne Cameron, Ms Mary and Dr Mehrnaz Shoushtarian risk of relapse. Re-admissions were almost Danoudis and Dr Thorlene Egerton, CRCMD&G, Southern Health; Dr completely abolished when comparing CRCMD&G, Southern Health. Peter Enticott, Alfred Psychiatry the periods before and after the start of Benefits: This study provides detailed Research Centre, Monash University. maintenance therapy. quantitative information about each Benefits: This study explores a patient’s progress following deep new avenue of documenting the brain stimulation, assisting in organisation and planning of gait Monash Ageing Research optimisation of the stimulation settings. function. This will involve a combination Centre The dissemination of results from of electroencephalogram and gait The Impact on Mental Health of Frequent the new techniques being used is an analysis to reveal cortical mechanisms Deaths that Occur in High Care in Aged important facet for further improvements associated with gait activity, and to Care Settings on Individuals and the in technique and development of new investigate cortical abnormalities among Resident Community. Researchers: technologies. individuals with movement disorders. Professors’ Margaret O’Connor, Daniel O’Connor, and Barbara Workman.
26 Southern Health Research Report 2010 27 RESEARCH GROUP REPORTS Ageing: Monash Ageing Research Centre (MONARC)
Preventing Falls & Improving Mobility Temporal-spatial gait characteristics Physiotherapy, Melbourne University; in People with PD: A Community and the stride length-cadence Ms Jennifer Watts, Monash University Based Program. Investigators: relationship of people with Progressive Centre for Health Economics & Monash Prof Meg E Morris, Melbourne School Supranuclear Palsy. Investigators: Institute of Health Service Research, of Health Sciences & Department of Dr Thorlene Egerton and Prof Robert Monash University; Dr Peter Kempster, Physiotherapy, Melbourne University; Iansek, CRCMD&G, Southern Health; Monash Medical Centre, Southern Prof Robert Iansek and Dr Anna A/Prof David Williams, Van Cleef Roet Health. Benefits: This project aims to Murphy, CRCMD&G, Southern Health; Centre for Nervous Diseases, Monash compare a complex care model, the Dr Frances Huxham, Physiotherapy University. Benefits: The systematic Victorian Comprehensive Parkinson’s Consultant, Southern Health; Dr assessment of the temporal-spatial Disease Program (VCPP) with usual Jennifer McGinley, Murdoch Children’s characteristics of gait among people care (conventional care), to determine Research Institute; A/Prof Hylton Menz, with PSP, and comparison to PD and which caters best for the complexity and Musculoskeletal Research Centre, healthy older adults (HOA), may identify cumulative morbidity over time of this La Trobe University; Ms Jennifer distinguishing features of PSP, elicit condition and at what cost. Watts, Monash University Centre for alternative treatment options and Health Economics & Monash Institute permit further understanding of Neuro developmental disorders: of Health Service Research, Monash normal gait control. Autism, Asperger’s disorder and University. Benefits:This project has Attention Hyperactivity Disorder - the potential of discovering a treatment Measurement & Reliability of Furthering current neurobehavioural that reduces falls and increases mobility Spatial-temporal Gait Variables and and clinical definitions. Investigators: in people with Parkinson disease. Activities of Daily Living using Inertial Nicole Papadopoulos, PhD Student, The interventions being trialled have Measurement Units. Investigators: Monash University; Dr Nicole unique potential for a very rapid clinical Dr Mehrnaz Shoushtarian, CRCMD&G, Rinehart and Prof John Bradshaw, translation and uptake across the entire Southern Health; Prof Subhash School of Psychology, Psychiatry, world and are novel, safe and viable. Challa and Dr Tharshan Vaithianathan, and Psychological Medicine Monash National Information & Communications University; Dr Jennifer McGinley, A RCT to determine the optimum Technology Australia. Benefits: This Murdoch Children’s Research Institute. frequency of Botulinum Toxin injections project aims to develop a wireless Benefits: This study will increase our to the calf in children with cerebral palsy. compact activity monitor using Inertial knowledge of the neurobehavioral Investigators: Prof H Kerr Graham Measurement Units (IMUs) that can presentation; most specifically and Dr Richard Baker, Hugh Williamson be worn around the ankle. Three- the neuromotor profile of children Gait Laboratory, RCH; A/Prof Barry dimensional inertial measurement units diagnosed with attention deficit Rawicki, VPRS, Southern Health; (IMUs) allow the recording of body hyperactivity disorder and will allow us Ms Tandy Hastings-Ison, RCH; segment movements in space and time. to explore similarities and differences Ms Christine Blackburn, Physiotherapy This can be used to collect information of motor difficulties in the context of Department, Southern Health; on a person’s gait and daily activities other neuro developmental disorders Dr Rory Wolfe, School of Applied in their usual living environment. Data (Autism & Asperger’s disorder). It will Clinical and Public Health Sciences, from the activity monitor can provide also increase our clinical definition of Monash University. Benefits: This critical information on the well-being of this disorder as it will describe motor study will compare the effects over a the elderly population, such as their gait difficulties referred to by our current two year period of annual Botulinum and postural stability. This information diagnostic classification system toxin A injections as against injections is valuable for falls prevention programs (DSM-IV) using empirically quantifiable every four months. The primary and monitoring interventions aimed at means of 2D gait analysis. This is the outcome measure will be the rate of improving mobility in the elderly. first study to our knowledge to use 2D development of contractures over gait analysis to describe the neuromotor that period. Measurements will also Comparison of Parkinson-related signature of children diagnosed with be made to determine whether either quality of life and cost effectiveness ADHD. Identification and quantification regime adversely affects muscle of a comprehensive service delivery of motor abnormalities will lead to the function, whether there is a difference model compared to usual care for implementation of effective treatment in functional ability and quality of life the management of people with and clinical interventions. of children and whether either leads to Parkinson’s disease. Investigators: increased secondary unresponsiveness. Prof Robert Iansek and Dr Anna Murphy CRCMD&G, Southern Health; Prof Meg E Morris, Melbourne School of Health Sciences & Department of
26 Southern Health Research Report 2010 27 RESEARCH GROUP REPORTS Ageing: Monash Ageing Research Centre (MONARC)
Botulinum toxin A injections for disease progression, or assess benefit New PW, Olver J, Cameron P, treatment of lower limb dystonia. of therapeutic interventions. Yet there is Stoelwinder J. Key stakeholders’ Investigators: A/Prof Barry Rawicki a paucity of literature that describes the perception of barriers to admission and Dr Anna Murphy, CGAS, common deviations of gait observed and discharge from inpatient subacute Southern Health; Dr Ettie Ben-Shabat, in these diagnostic groups when care in Australia. Web-based survey. Ms Adele Winter and Ms Ashley compared to healthy normal people, Mooney, Dept of Physiotherapy, or that quantifies the prevalence Milne SC, Campagna EJ, Corben LA, Caulfield Hospital; Dr Mithu Palit, and/or extent of these gait deviations. Churchyard AJ, Delatycki MB, Teo K, Prof John Olver and Dr Stephen De The project aims to identify, describe Haines TP. A retrospective study of Graaff, Dept of Rehabilitation, Caulfield and quantify the more common/ the effects of in-patient rehabilitation Hospital; A/Prof Anne Holland, Dept of prevalent gait abnormalities observed on improving and maintaining Physiotherapy, Alfred Health/LaTrobe in adult patients diagnosed with HSP, functional independence in people University. Benefits: The aim of this CP and SCI. with Friedreich’s ataxia. The Functional study is to use detailed and sensitive Independence Measure was utilised walking measurements obtained to determine the efficacy of inpatient with Gait Analyses to assess whether Rehabilitation rehabilitation compared to a decline BoNT/A injections actually improve the New PW, Scroggie G, De Morton N. over time. walking patterns of clients with lower Evaluation of the Clinimetric Properties limb dystonia. Hence, this study is an of the de MORTON Mobility and Index observational study. The outcomes (DEMMI) in Rehabilitation Patients. PUBLICATIONS, and significance of this study will be The primary aim of this project is to POSTGRADUATE STUDENTS in providing an objective measure to validate a newly developed mobility AND FUNDING SUMMARY assess the effectiveness of BoNT/A tool for use in the acute rehabilitation injections for management of lower setting and transition from inpatient Journal articles 16 limb dystonia. If BoNT/A injections rehabilitation to early community phase. Book chapters 2 for dystonic lower limbs are found to There are a number of secondary aims improve gait measures, then results will including: assessing the utility of two Conference presentations 40 provide evidence-based practice for well known comorbidity measurement management of lower limb dystonia. tools to help predict patient outcomes, Postgraduate research students 4 Furthermore, such results will provide recording the impact of patient support for future funding of costly complications, and determining the BoNT/A injections in the management prevalence and impact of obesity Funding: of lower limb dystonia. on patient outcomes. Competitive Identification and quantification of New PW. Outcomes from a Dementia CRC, Project grant. Unlocking the common gait abnormalities in rehabilitation program targeted at the potential of volunteers in aged adult patients with Hereditary Spastic patients with severe neurological residential facilities to support residents Paraparesis (HSP), Cerebral Palsy deficits. Prospective data collection with behavioural and psychological (CP) and Spinal Cord Injury (SCI). continuing in this observational study symptoms of dementia: a pilot feasibility Investigators: A/Prof Barry Rawicki, of patients admitted to the ‘Step-Down study. O’Connor D, van der Ploeg E. Dr Anna Murphy, Grant Scroggie, Program’ at Kingston Centre. 2010: $19,645 (Monash University). Dianne Cameron, Robyn Gardiner, Susan Wilson. Benefits:This project New PW, Shum K. Surveillance of NHMRC, Project grant. A randomised is a retrospective descriptive study prescription of proton pump inhibitors controlled trial of personalised goal- aiming to identify and quantify the more (PPI) in patients admitted for inpatient directed activity to treat agitation in common/prevalent gait abnormalities rehabilitation. Prospective observational dementia. O’Connor D, Camp C, Runci observed in adult patients diagnosed study on the prevalence of patients S, King M. 2010: $133,250. 2010-2012: with HSP, CP and SCI. Abnormalities prescribed PPI who do not meet $300,625 (Monash University). of gait are observed and reported published guidelines for indications JO & JR Wicking Trust, Project grant. frequently in adult patients diagnosed and/or dose. Spouses of aged care residents: with HSP, CP and SCI. Patients are New PW, Olver J, Cameron P, promoting wellbeing through support frequently referred for three dimensional Stoelwinder J. Prospective multi-centre groups. McSweeney K, O’Connor D. (3D) clinical gait analysis to assist observational study of barriers to 2010: $47,860. 2010-2011: $147,472 in clinical decision making, monitor discharge from inpatient rehabilitation. (Monash University).
28 Southern Health Research Report 2010 29 RESEARCH GROUP REPORTS Ageing: Monash Ageing Research Centre (MONARC)
NHMRC, Project grant. A controlled trial Caulfield Hospital ‘Improving care of topical lavender oil as a treatment for older people and people with of behavioural symptoms of dementia. complex needs’ scholarship, O’Connor D, Lees G, Runci S, King M. Project Grant. Botulinum toxin A 2010: $101,300. 2009-2010: $204,650 injections for treatment of lower limb (Monash University). dystonia. Palit, M., Ben-Shabat, E., Rawicki, B., Murphy, A. 2010: $19,500. ARC Linkages, Project grant. Ageing 2010-2011: $19,500 (Caulfield Hospital in prison: a strategic framework for the & Southern Health). management of ageing offenders in the Australian criminal justice system. Allergan Pty Ltd, Project Grant. Trotter C, Browning C, O’Connor D, Identification and quantification of Collier P, Sheehan R. 2010: $60,000. the common gait abnormalities in 2010-2011: $130,000 (Monash adult patients with Hereditary Spastic University). Paraparesis (HSP), Cerebral Palsy (CP) and Spinal Cord Injury (SCI). Department of Health and Ageing, Rawicki, B., Murphy, A. 2010: $1,641.00. Project grant. The impact on mental 2009-2012: $20,000 (Southern Health). health of frequent deaths that occur in high care in aged care settings on Aust. Assoc. of Gerontology (AAG) - individuals and the resident community. RM Gibson Scientific Research O’Connor M, Workman B, O’Connor D. Fund, Project Grant. The effect of 2010: $180,703. 2010-2011: $271,766 fatigue on attentional resources (Monash University). required for the postural stability of older people. Egerton, T. 2010: Mason Foundation, Project grant. $5,000 (Southern Health). A pilot randomised controlled trial of personalised goal-directed activity Other to treat agitation in dementia. O’Connor D, van der Ploeg E. 2010: Lions John Cockayne Memorial $20,000. 2009-2010: $40,000 Fellowship Trust Fund, Project Grant. (Monash University). Identification of cerebral electrical potentials and wave forms in the control National Parkinson Foundation of gait. Iansek, R., Enticott, P., Murphy, (NPF), Project Grant. Comparison of A., Shoushtarian, M. 2010: $1,621.73 Parkinson-related quality of life and (Southern Health). cost effectiveness of a comprehensive service delivery model compared Lions John Cockayne Memorial to usual care for the management Fellowship Trust Fund, Project Grant. of people with Parkinson’s disease. Measurement & reliability of spatial- Iansek, R., Morris, M., Watts, J., temporal gait variables and activities Kempster, P., Murphy, A. 2010: of daily living using inertial measurement US$90,000 (AUS $101,477). 2010-2012: units. Iansek, R., Shoushtarian, M. 2010: US$180,000 (Southern Health). $6,669.12 (Southern Health).
NHMRC, Project Grant. Motor Lions John Cockayne Memorial functioning in Autism and Asperger’s Fellowship Trust Fund, Project Grant. Disorder: Furthering current Intervention to improve gait in neurobehavioural and clinical chronic stroke: A pilot study. Iansek, definitions. Rinehart, N., Tonge, B., R., Cameron, D. 2010: $3,094.48 Bradshaw, J., Iansek, R., McGinley, (Southern Health). J., Murphy, A. 2010: $7,746. 2007- 2009: $341,878 (Monash University & Southern Health).
28 Southern Health Research Report 2010 29 RESEARCH GROUP REPORTS
Allied Health
GENERAL MANAGER: MS ATHINA GEORGIOU
DIRECTOR OF RESEARCH: DR TERRY HAINES
Allied health departments of Southern Health comprise a diverse group of health professionals working across the spectrum of services offered by the organisation.
The Allied Health Research Unit is Funding: Australian Primary Health Care a collaborative network of Monash Research Institute, Project grant. University and Southern Health Competitive Utilisation of allied health services by researchers. The unit seeks to facilitate • Southern Metropolitan Integrated people with chronic disease: differences the development of research by and in Cancer Service (SMICS) Supportive across health insurance coverage and collaboration with allied health clinicians Care Research Grants 2010-11, Project policy change. Foster M, Haynes M, and others across Southern Health, Grant. Multidisciplinary management of Haines T, Mitchell G. 2010: $75,000. to conduct innovative research that Glioblastoma Multiforme patients and 2010-2011: $149,364 (University of advances clinical practice, and to enable carer burden: A prospective pilot study Queensland). allied health clinicians to judiciously use across the disease trajectory. Downie, evidence to guide their clinical practice. Department of Health Victoria, S (OT), O’Connor, G (RN) and Long, Research tender. Education and training B (Neuropsych). 2010: $7,490. 2011- package in exercise prescription for PUBLICATIONS, 2013: $29,960 (Southern Health). falls prevention. T Haines, J Keating, B POSTGRADUATE STUDENTS Butterfly Foundation, Project Grant. Jolly, L Molloy, J Sims. 2010: $124,209 AND FUNDING SUMMARY Cluster randomised controlled trial (Monash University). of “Girls on the Go” for enhancing Southern Health Emerging Researcher Journal articles 37 self-esteem amongst school-aged Fellowship, Project Grant. Reliability and girls. Truby H, Haines T, Tirlea L. Book chapters 1 Validity of an Upper Limb Assessment 2010: $100,000. 2010-2012: $200,000 Tool (ULAT) for Acute Neuroscience Conference presentations 49 (Monash University). Patients. Downie, S (OT). 2010: $15,000. 2009-2010: $30,000. Postgraduate research students 26 NHMRC, Career Development Award. Haines T. 2010: $95,000. 2010-2013: Department of Health – Victorian $380,000 (Monash University). travelling Fellowship program, NHMRC and Department of Health, Scholarship. To develop, implement Partnership Project. Evidence based and increase the skill base of remote targeting of statewide strategies for clinicians to further support metropolitan preventing falls among community based hand therapy centres. Zoe Milner. dwelling older people in Victoria. L Day, 2010: $19,845. 2010-2011: $19,845 C Finch, K Hill, T Haines, L Clemson. (Southern Health). 2010: $180,000. 2010-2013: $556,271 AASW, Research grant. Learning (Monash University). To Practice. Glenda Kerridge. 2010: $5,000. 2010-2011: $5,000 (Southern Health).
30 Southern Health Research Report 2010 31 RESEARCH GROUP REPORTS Allied Health
Speech Pathology Australia and Dietetics Association of Australia, Project grant. Evaluation of the uptake of the Australian Standardised Terminology and Definition for Texture Modified Food and Fluids. Jukes, S., O’Rourke, M. 2010: $15,750 (Southern Health).
AASW, Project grant. Learning to practice: an evaluation of the student learning module at Southern Health. Glenda Kerridge. 2010: $5,000 (Southern Health).
AASW, literature review grant. Self-management of chronic disease. Kelsay Smith. 2010: $3,000.
Other Life threatening cancer across the lifespan: Examining the relevance of music to children (0-14 years). Baron, A., and non Southern Health collaborators: O’Callaghan, C., Barry, P., Dun, B. No funding received. Southern Health (Multi-site project completed Feb 2010 with Peter MacCallum Cancer Centre and Royal Children’s Hospital)
Southern Health Emerging Researcher Fellowship. A pilot cluster randomised controlled trial of “Girls on the Go” for enhancing self-esteem amongst school-aged girls. Tirlea L. 2010: $30,000 (Southern Health).
Southern Health Emerging Researcher Fellowship. Heel raises versus prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis (Sever’s Disease): a randomised control trial. James A. 2010: $30,000 (Southern Health).
30 Southern Health Research Report 2010 31 RESEARCH GROUP REPORTS
Anaesthesia and Peri-operative Medicine
DIRECTOR: DR JOHN MONAGLE
Anaesthesia and Pain Management is a multi-site department providing services to all sites of Southern health and covering all aspects of the craft of anaesthesia.
Research is primarily collaborative with This project was the winner of the Southern Funding: other centres focusing on anaesthetic Health Senior Medical Staff Research outcome investigations. Internally there is Award in 2009, has been accepted for an Competitive a focus on research around education and oral presentation at the 1st International ANZCA, Project Grant. Multi-source trainee assessment, as well as assessment Conference on Faculty Development in the feedback for workplace-based of senior medical staff performance. Health Profession in May 2011 in Toronto, assessment of trainees in anaesthesia. and has been submitted for publication. Castanelli D, Noonan C, Monagle J, RESEARCH ACTIVITIES Ilic D, Kitto S. 2010: $10,000 Multicentre trials: (Southern Health). Multi-source feedback for workplace-based GAS-A multi-site RCT comparing assessment of trainees in anaesthesia (PI: regional and general anaesthesia Damian Castanelli, Craig Noonan, John for effects on neurodevelopmental Monagle, Dragan Ilic, Simon Kitto). This outcome and apnoea in infants. project, which is still in progress, aims to The primary objective of this trial is to develop, implement and evaluate a tool to determine whether different types of provide feedback to anaesthetic registrars anaesthesia [regional versus general] from their co-workers in order to assist given to infants undergoing inguinal them in their professional development. hernia repair result in equivalent The project received an ANZCA (Australia neurodevelopmental outcomes. and New Zealand College of Anaesthetists) Project Grant of $10,000. The tool has ENGIMA II been developed and implemented The purpose of this project is to evaluate and analysis of the implementation the safety and benefits of using nitrous and evaluation data has commenced. oxide as part of the general anaesthesia Although still incomplete, information from gas mix in patients with cardiac disease this project has been used by ANZCA having non-cardiac surgery. in formulating new workplace-based assessments for trainees in anaesthesia in Australia and New Zealand. PUBLICATIONS, AWARDS,
Investigating the perceptions, attitudes, POSTGRADUATE STUDENTS and beliefs of staff anaesthetists related AND FUNDING SUMMARY to multi-source feedback used for their Journal articles 3 performance appraisal (PI Damian Castanelli). Consultant anaesthetists Conference presentations 5 at Monash Medical Centre receive multi-source feedback as part of their performance appraisal. This completed project used qualitative interviews to explore their responses to the feedback and the system of its delivery.
32 Southern Health Research Report 2010 33 RESEARCH GROUP REPORTS REPORTS GROUP RESEARCH RESEARCHMedicine Peri-operative GROUP and REPORTSAnaesthesia
Cardiology: MonashHEART and Monash Cardiovascular Research Centre
DIRECTOR: PROFESSOR IAN MEREDITH DIRECTOR OF RESEARCH: PROFESSOR JAMES CAMERON
MonashHEART provides tertiary referral services in cardiology to a direct catchment of more than 750,000 people and an indirect catchment of a further quarter of a million people.
International standard clinical and Field triage of patients with Heart extension of field ECG triage of STEMI transitional research undertaken within Attacks (STEMIs) – The MonAMI patients to all mobile intensive care MonashHEART through the Monash project (Ian Meredith, Yuvi Malaiapan, ambulance units of the Metropolitan Cardiovascular Research Centre (MCRC) Adam Hutchison and Jim Cameron). Ambulance Service in Melbourne and supports the continued uptake by Southern Time to treatment is an important other hospital networks outside of Health clinical services of state-of-the-art determinant on outcome in patients Southern Health. The program was also cardiological treatments and improves the presenting with heart attacks (ST recognised by The Australian Council cardiovascular health and outcome of the elevation myocardial infarction, on Healthcare Standards winning the people of Melbourne, of Victoria and on a STEMI). International guidelines 2010 Quality Improvement Award in the national and international level. mandate that >75% of patients Clinical Excellence and Patient Safety with STEMI should receive specific category. This pioneering work by MCRC is the independent research treatment - primary percutaneous MonashHEART truly has the potential to group of MonashHEART within the coronary intervention (PPCI) - within 90 improve health outcomes for Southern Faculty of Medicine, Nursing and minutes of presentation. Despite these Health patients, all Victorians and with Health Sciences at Monash University recommendations, this goal has been national and international ramifications. (through the Southern Clinical School and difficult to achieve. Departments of Medicine and Surgery, Investigation of Cardiac CT Perfusion Monash Medical Centre). The MCRC is A prospective interventional study of Imaging in Clinical Practice (Sujith also the formally recognised research patients undergoing PPCI at Monash Seneviratne, Brian Ko, Arthur Nasis, arm of MonashHEART and is responsible Medical Centre was commenced Jim Cameron). This work from the for research functions as detailed in the in 2007 to determine the impact of MonashHEART cardiac CT program MonashHEART and Southern Health pre-hospital 12-lead ECG triage and investigates the potential for cardiac Strategic Plan. emergency department activation of CT perfusion studies in the clinical the infarct team on door-to-balloon time setting as an addition to cardiac CT (D2BT). The median D2BT of all patients angiography. Multidetector CT coronary RESEARCH ACTIVITIES who underwent PPCI after field ECG angiography is a robust non-invasive and emergency department activation method for the accurate diagnosis There were four major components of of the infarct team has been significantly of coronary artery disease (CAD). It MonashHEART translational research reduced with the introduction of this has high sensitivity and very good activities during 2010: program (down to 56 minutes). negative predictive value for excluding Around 90% of patients undergoing significant CAD and is increasingly pre-hospital ECG achieved a D2BT recognised as the imaging modality of of under 90 minutes. Ongoing choice in evaluation of symptomatic investigation looking at mortality patients with suspected CAD. Its ability benefits is currently underway. to detect hemodynamically significant stenoses is relatively low and selected The truly translational nature of this populations continue to require research and the success of this trial nuclear and echocardiographic stress has been recognised by government testing to confirm the presence of any and public health organisations with the
32 Southern Health Research Report 2010 33 RESEARCH GROUP REPORTS Cardiology: MonashHEART and Monash Cardiovascular Research Centre
significant myocardial ischemia. CT of the elderly with many affected Comparison of Cardiac CT Angiography myocardial perfusion stress imaging patients having significant medical (CCTA) with Transoesophageal is an emerging non-invasive modality co-morbidities that make them Echocardiography (TOE) in patient to detect myocardial ischemia. This unsuitable for traditional aortic valve selection and follow-up for the has been enabled by CT technological replacement (AVR). Transcatheter implantation of the WATCHMAN left advances including the introduction of aortic valve implantation (TAVI) with atrial appendage occlusion device wide (320-slice single beat) detectors the CoreValve® Re-valving System (Jeff Alison, Siobhan Lockwood, with improved spatial and temporal is a therapeutic alternative for highly Philip Mottram, Julie Plunkett, Kapil resolution which allows acquisition selected elderly patients for whom Kumawatt, Manoj Obeyesekere). of the entire volume of the heart in a AVR is not a viable option. Paroxysmal, persistent and permanent single heart beat and with low radiation atrial fibrillation (AF) in patients exposure. Furthermore, perfusion MonashHEART was the first site with demonstrated risk factors for assessment is independent of ischemia in Australasia to be accredited to thromboembolic complication is an in adjacent territories, which may perform TAVI with the CoreValve® indication for long term anticoagulation. potentially position cardiac CT as a one Re-valving System. Enrolment in our The part of the heart known as the stop imaging modality to assess both TAVI program is currently under the left atrial appendage (LAA) has been coronary anatomy and perfusion which auspices of the Australia/New Zealand shown to be the site of thrombus (blood offers added convenience. CoreValve® ReValving registry with clot) accumulation and subsequent strict inclusion and exclusion criteria. embolisation in over 90% of patients Whilst early studies demonstrated Since our program commenced in with AF who suffer stroke or other comparable diagnostic accuracy of 2008, we have performed 40 TAVI major embolic events. Anticoagulation CT perfusion against single photon procedures, including 17 cases in 2010. significantly reduces the likelihood of emission CT imaging, our CT perfusion As one of the highest volume TAVI clot development within the left atrial research program in collaboration centers in Australasia, MonashHEART appendage and reduces the incidence with the MonashHEART interventional has provided invaluable data in this of stroke. services is the first to demonstrate emerging field which has been utilized comparable diagnostic accuracy nationally and internationally in the The WATCHMAN® LAA occlusion against an invasive gold standard development of future registries and device has been developed as an - invasive intracoronary pressure TAVI protocols. Accurate measurement alternative to anticoagulation for the derived assessment of fractional flow of aortic valve anatomy, especially aortic prevention of clot embolisation from the reserve. Our work is also the first to valve annulus dimension is critical for LAA. The device creates a mechanical demonstrate that this can be achieved patient selection and prosthesis sizing. barrier between the LAA and the rest with an acceptable radiation exposure of the arterial circulation. The Cardiac using 320 row detector cardiac CT and At MonashHEART we uniquely utilize Rhythm Management Service within prospective ECG gating. 320-slice multi-detector computed MonashHEART began its WATCHMAN® tomography (MDCT) technology in implantation program in November This work has broadened to include the pre-procedural assessment of 2009. As part of this program the evaluation of the applicability of potential TAVI patient. As a result of this established use of Transoesophageal CT perfusion in a wider population, experience MonashHEART have been Echocardiography (TOE) in the including symptomatic patients able to demonstrate the utility of this selection of patients with suitable with suspected CAD and patients technology in the evaluation of the aorta LAA anatomy is being compared with with suspected acute coronary and aortic valve anatomy non-invasively cardiac CT imaging with results to date syndrome (heart attack) but with low prior to TAVI with results equivalent to indicating equivalent if not superior to intermediate risk of coronary artery or better than other invasive imaging accuracy for cardiac CT in determining disease. Our CT perfusion program modalities. Furthermore, MonashHEART LAA shape and size. As well follow-up is committed to evaluate diagnostic work has provided a wealth of of the WATCHMAN® device requires accuracy in these clinical settings information regarding the short and long assessment of adequacy of LAA using the invasive gold standard, term clinical and echocardiographic occlusion at 45 days before ceasing as well as the role of quantitative outcomes of patients undergoing TAVI anticoagulation medicine and follow-up CT and the accuracy of stress CT in addition to being one of the first TOE examination is standard practice. coronary angiography. centres to study patient reported quality of life following a successful TAVI. MonashHEART is investigating if cardiac MonashHEART implemented a MonashHEART through its involvement CT is equally sensitive in detecting significant translational research in the CoreValve® Re-Valving registry residual para-device leaks that may program in transcatheter aortic valve is committed to providing a safe and require delay of anticoagulation implantation (TAVI) (Ian Meredith, Paul effective therapeutic alternative to cessation. As the WATCHMAN® Antonis, Siobhan Lockwood, Julian traditional AVR in appropriately program continues, increasing patient Smith, Randall Moshinsky). Severe selected patients. numbers will provide more robust data aortic stenosis is commonly a disease as well as analysis of outcome data such as risk/benefit comparisons and overall effect on stroke incidence.
34 Southern Health Research Report 2010 35 RESEARCH GROUP REPORTS Cardiology: MonashHEART and Monash Cardiovascular Research Centre
PUBLICATIONS, Commercial Project: Resolute. Sponsor: Medtronic. Project: CAREII. POSTGRADUATE STUDENTS Investigator: I Meredith AND FUNDING SUMMARY Sponsor: CardioMind. Investigator: I Meredith Project: DAPT. Journal articles 25 Sponsor: HCRI. Project: CathRX. Investigator: I Meredith Conference presentations 35 Sponsor: CathRX. Investigator: D Adam Project: SPIRIT PRIME. Postgraduate research students 2 Sponsor: Abbott Vascular. Project: e-Select Registry. Investigator: I Meredith Sponsor: Cordis. Funding: Investigator: I Meredith Project: Taxus Atlas. Competitive Sponsor: Boston Scientific. Project: CoreValve. Investigator: I Meredith National Heart Foundation of Australia, Sponsor: Medtronic. Project Grant. Effect of Ambulance Investigator: I Meredith Project: Top II. Based Diagnosis on Heart Attack Sponsor: TriReme Medical. Project: Aquarius. Outcome. Cameron JD, Meredith IT. Investigator: I Meredith 2010: $57,675.00. 2009-2010: $115,350 Sponsor: Novatis. over 2 years (Monash University). Investigator: J Cameron Project: Zomax I. Sponsor: Abbott Vascular. Project: Diverge. Royal Australian College of Physicians, Investigator: I Meredith Research Fellowship. Dundon B, Sponsor: Devax. Cameron JD. 2010: $60,000 (Monash Investigator: I Meredith Project: Zomaxx II. Sponsor: Abbott Vascular. University). Project: Excella II. Investigator: I Meredith NHMRC Overseas Based Biomedical Sponsor: Elixir Medical. Fellowship, NHMRC Post-doctoral Investigator: I Meredith Project: Evolve. Sponsor: Boston Scientific. Fellowship. White AJ. 2010: $69,750. Project: Nobori. Investigator: I Meredith 2010-2011: $331,271.76 (Monash Sponsor: Terumo. University). Investigator: I Meredith Project: Absorb Cohort B. Sponsor: Abbott Vascular. CV Forum Specialists Meeting (Pfizer), Project: Branch. Investigator: I Meredith Travel Grant. Cardiovascular travel Sponsor: Medtronic. grant. Thai W-E. 2010: $2000 (Southern Investigator: I Meredith Project: Absorb Extend. Health). Sponsor: Abbott Vascular. Project: Perseus. Investigator: I Meredith National Medical Research Council, Sponsor: Boston Scientific. Singapore, Project Grant. Retinal Investigator: I Meredith Project: Rhythm AF. vasculature changes, large arterial Sponsor: Merck Sharp & Dohme. stiffness and nocturnal blood Project: Platinum. Investigator: J Allison pressure patterns: The associations Sponsor: Boston Scientific. and prognostic implications of three Investigator: I Meredith Other novel vascular risk factors in ischemic stroke patients. De Silva, DA, Wong Project: Platinum QCA. Flinders Coordinating Centre. TY, Chang HM, Kingwell BA, Cameron Sponsor: Boston Scientific. ANTS. I Meredith. 2010: $4,000 JD, Woon FP, Ting CM, See SJ. 2010: Investigator: I Meredith (Southern Health). S$61,333.00. 2009-2011: SGD $184,000 Project: Protect. over 3 years (Singapore Neuroscience Concord Clinical trials. Sponsor: Medtronic. Institute). Concordance. P Antonis. 2010: $25,020 Investigator: I Meredith (Southern Health).
Project: REMEDEE Study. Sponsor: OrbusNeich. Investigator: I Meredith
Project: Res-elution. Sponsor: Cordis. Investigator: I Meredith
34 Southern Health Research Report 2010 35 RESEARCH GROUP REPORTS
Cardiothoracic Surgery
DIRECTOR: PROFESSOR JULIAN SMITH
2010 has seen the ongoing maintenance of excellent patient outcomes in Cardiac and Thoracic Surgery.
The department continues to contribute RESEARCH ACTIVITIES be an important orchestrator of the patient outcome data to the Australasian inflammatory response to cardiac Society of Cardiac and Thoracic Surgeons Completed and current projects include surgery. Neutralising its action using National Cardiac Surgery Database. The the following: follistatin may be a useful therapeutic observed and risk adjusted mortality option in the future. rates and complication rates from cardiac Activins in cardiopulmonary bypass surgery are equal to or superior to national (Y. Chen, J. Goldstein, J. McMillan, Australasian Society of Cardiac and and international benchmarks. Particularly J. Smith). Activin A, a member of the Thoracic Surgeons database: trends gratifying was the low incidence of transforming growth factor-β superfamily, in mitral valve surgery for degenerative patients returning to the operating theatre is a novel cytokine released early in a disease (P. Joshi, A. Almeida). Several for post-operative haemorrhage and broad range of inflammatory disorders. trends may be observed from a review the low incidence of peri-operative and Its role has not been investigated in of the data. Fewer mitral valve repairs post-operative blood and blood product the setting of cardiac surgery. Our are performed without an annuloplasty transfusion. study aimed to determine whether ring. The percentage of mitral valve cardiopulmonary bypass or ischemia- repairs remains relatively unchanged The department continues to publish reperfusion injury – two primary sources since 2003. When valve replacement widely on basic, clinical and collaborative of inflammation in cardiac surgery – is is performed bioprosthetic valves are cardiac and thoracic surgical research. a trigger for activin A release. A sheep more frequently implanted. Particular recent research interests have model of cardiopulmonary bypass was
focused on the inflammatory response used to establish the release profile of Australasian Society of Cardiac to cardiopulmonary bypass, patient activin A. A biphasic pattern of release and Thoracic Surgeons database: outcomes after bioprosthetic aortic valve of this critical cytokine similar to that acute kidney injury after replacement, cardiothoracic surgery seen in endotoxemia was found. Using cardiopulmonary bypass (A.Cochrane). databases, and less invasive and a mouse model of ischemia-reperfusion New post-operative renal impairment robotically assisted cardiac valve surgery. injury, we identified that the activin A resulted in major mortality, and gene was rapidly up-regulated during prolonged ICU stay and hospitalization. reperfusion. Myocardial infarct size was A risk prediction model has been significantly reduced if follistatin, a high- created from a large Australian affinity activin A binding protein, was database, with the 10 most important pre-administered. risk factors demonstrated. The most important predictive factor was the Further, we found that neutrophils pre-operative creatinine level. contained pre-stored activin A and
were thus a possible source of activin Results of valve replacement surgery A released in vivo. Taken together, with the Medtronic Mosaic bioprosthesis this series of experiments suggest (A. Koenen, J. Goldstein). Excellent that activin A is released systemically early and mid-term results were during cardiac surgery and may obtained with this bioprosthesis.
36 Southern Health Research Report 2010 37 RESEARCH GROUP REPORTS Cardiothoracic Surgery
PUBLICATIONS AND FUNDING SUMMARY
Journal articles 6
Books 1
Book chapters 2
Conference presentations 10
Funding:
Competitive ARC, Discovery Project Grant. High-fidelity modelling for robotic assisted minimally invasive needle insertion. B. Shirinzadeh, Y. Zhong, J. Smith. 2010: $50,000. 2009-2011: $150,000 (Monash University).
36 Southern Health Research Report 2010 37 RESEARCH GROUP REPORTS
Clinical Immunology
DIRECTOR: PROFESSOR STEPHEN HOLDSWORTH
The Clinical and Diagnostic Immunology Department provides laboratory, diagnostic and clinical consultative and support services for patients with various forms of immune disease including immunodeficiency, autoimmunity and allergy.
These diseases collectively afflict 20% RESEARCH ACTIVITIES PUBLICATIONS, of all Australians. The department employs a number of diagnostic platforms The flow cytometry service supports a POSTGRADUATE STUDENTS that not only provide high quality number of research projects including: AND FUNDING SUMMARY diagnostic tests but are also critical to Journal articles 10 research efforts of many of the research Dr Caroline Gargett (Endometrial Stem Cell Group): Identification of groups in the whole network. The flow Book chapters 1 cytometry services provide a network endometrial cancer stem cells surface wide research service and supports many markers in order to isolate and study Conference presentations 3 productive research projects listed under the initiation and progress of disease. the third dot point below. Postgraduate research students 3 Dr Paul King (Centre for Inflammatory Diseases): Characterisation of the T-lymphocyte response to NTHi infection Funding: RESEARCH ACHIEVEMENTS by studying lung samples from patients Competitive IN 2010 with chronic obstructive pulmonary disease (COPD). NHMRC, Project Grant. Studies of bronchiectasis showing Mechanisms of disease in humans how aberrant immune responses to Professor Bill Sievert (Centre for with MPO-ANCA associated lung viral infection contribute to chronic Inflammatory Diseases): Identification glomerulonephritis. Holdsworth, S. lung damage. and isolation of Kupffer cells with stem 2010: $174,757. 2010-2012: cell like properties from liver samples of The previously unknown role of mast $514,500 (Monash University). patients with Hepatitis C. cells (previously thought to be only NHMRC, Project Grant. relevant to allergy) in the regulation Dr Ursula Manuelpillai (Centre for Immunoregulation in the pathogenesis and development of autoimmunity. Reproduction and Development): and therapy of autoimmune anti Identification of cells with stem cell like Studies provide new laboratory assay myeloperoxidase glomerulonephritis. properties of amnion epithelial cells for assessing the functional capacity Holdsworth, S. 2010: $92,983. isolated from human term delivered of the immune system of patients 2010-2012: $273,750 placentae. with organ transplants and chronic (Monash University). viral infections. Professor Eric Morand (Centre for Inflammatory Diseases): Investigation of the expression and function of the protein GILZ in animal models of rheumatoid arthritis in order to find alternatives to glucocorticoid therapy in rheumatoid arthritis.
38 Southern Health Research Report 2010 39 RESEARCH GROUP REPORTS
Colorectal Surgery
DIRECTOR: ASSOCIATE PROFESSOR BRUCE WAXMAN
The Surgery Program at Dandenong Hospital performs a broad range of general and colorectal surgery with a research focus on colorectal disorders, disaster preparation and surgical education.
RESEARCH HIGHLIGHTS A stroke of luck or just the ideal model of care? – Associate Professor IN 2010 Bruce P Waxman Role of computed tomography Clinical research, carbon emissions, angiogram in Lower GI Bleed. climate change and Copenhagen – Biogrid Colorectal Cancer Research – our lifestyle on the line? – Associate Lifestyle questionnaires. Professor Bruce Waxman
Current projects PUBLICATIONS AND Biogrid Colorectal Cancer Research FUNDING SUMMARY – Participation in data collection and lifestyle questionnaires – Principal Journal articles 12 Investigator – Mr Peter Gibbs Book chapters 1
Medicine in Small Doses – Conference presentations 6 Associate Professor Bruce Waxman
Colorectal Cancer Database – Funding: A prospective study – Mikhail Fisher Competitive Transanal Endoscopic Microsurgery –
T C Nguyen Victorian Cancer Agency. EO109-32 Translational Research Enhanced Recovery after Surgery – Program. Gibbs P, Waxman BP. P Y Tan (Biogrid/Southern Health).
Role of computed tomography angiogram in Lower GI Bleeding – Kowsalya Murugappan
Complication rate and length of stay in patients with appendectomy transferred from a peripheral hospital with no acute surgical services to a major hospital – Rajagopalan Devanathan
38 Southern Health Research Report 2010 39 RESEARCH GROUP REPORTS
Diabetes Unit
DIRECTOR: PROFESSOR HELENA TEEDE
The Southern Health Diabetes Research Unit is integrated with the Jean Hailes Clinical Research Unit and is affiliated with both Southern Health and Monash University sitting within the School of Public Health and Preventive Medicine, located at Monash Medical Centre, Clayton.
The integrated research team is focusing Diabetes health services research The research team will be enhanced in on the continuum of adverse lifestyle, confirmed the successful new models of 2011 with the following additions to staff: obesity, insulin resistance, insulin resistant care in diabetes, entitled diabetes support syndromes including metabolic syndrome services based at Monash and Clayton. Professor of Women’s Mental Health and polycystic ovary syndrome (PCOS), These triage and acute management – to undertake research to create new gestational diabetes, pre-diabetes, services provide limited service provision knowledge and to translate physical diabetes and cardiovascular disease. (2-3 visits) and develop management plans and emotional well being for Australian The progression through this continuum to be actioned in the community. Diabetes women. The Professor joins us with a is not inevitable and our research focuses control improved considerably (reduced team of six. on prevention and translation of evidence HbA1C by 1.5%). Head of Indigenous Women’s Health to optimise prevention. The unit also Program – to undertake research to conducts an extensive women’s mental The large International Diabetes Federation create new knowledge and to translate health and menopause research program. project on prevention of weight gain in knowledge into action targeting women, The team collaborates locally, nationally those pregnant women at high risk of health professionals and policy makers and internationally in projects with other diabetes was run in Southern Health to optimise physical and emotional Southern Health units and with external antenatal clinics and completed recruiting wellbeing for Indigenous Australian research organisations. in 2010 with results due in 2011. women. Multidisciplinary higher degree research student supervision was successful with Establishment of a new clinical research RESEARCH ACTIVITIES three submissions and two new enrolments service to support clinical research at Southern Health to commence in 2011. In 2010 the integrated Jean Hailes in 2010. Foundation/Southern Health diabetes The research team also engaged in or research teams extended collaborations led national evidence based guidelines PUBLICATIONS, AWARDS, both internally with Southern Health across type I and II diabetes and PCOS. (renal, cardiothoracic surgery, nutrition, POSTGRADUATE STUDENTS obstetrics and gynaecology, psychiatry, Dr Catherine Lombard published the AND FUNDING SUMMARY cardiology) and externally. The team results of her PhD as first author in Journal articles 29 expanded by engaging a new Professor BMJ. She was awarded a prize by the of Women’s Mental Health and her team; School of Public Health for her thesis Conference presentations 43 a Clinical Epidemiology and Biostatistics on prevention of weight gain in women team bringing vital clinical research and her work has attracted international Awards 1 methodologies including biostatistics/ and national funding including a three epidemiology/trial design; and an year postdoctoral fellowship. Dr Sophia Postgraduate research students 8 Indigenous Women’s Public Zoungas, a postdoctoral fellow and a Health Researcher. member of the Southern Health diabetes unit, had an outstanding year with a first author publication in New England Journal of Medicine and a remarkable publication year overall.
40 Southern Health Research Report 2010 41 RESEARCH GROUP REPORTS
Diagnostic Imaging
DEPARTMENT DIRECTOR: PROFESSOR STEPHEN STUCKEY
The Department of Diagnostic Imaging, Southern Health, is involved in a wide variety of clinical research.
Although a significant proportion of this PUBLICATIONS, AWARDS research is primarily driven by Diagnostic Imaging we are particularly enthusiastic AND FUNDING SUMMARY to foster collaboration with clinicians of Journal articles 33 Southern Health and Monash University but also with collaborators external to Conference presentations 43 Southern Health, interstate, and overseas. The department also participates in Awards 1 providing imaging services to researchers as part of funded clinical trials external to Funding: Diagnostic Imaging. Competitive The key areas of original research Victorian Department of Health, conducted within the department include Project Grant. Fetal MRI – cost MRI and neuroimaging, ultrasound, effectiveness and change to diagnosis cardiac CT, PET and nuclear medicine, and management. S.Goergen, M.Fink paediatric imaging, fetal MRI, and health (RCH). 2006 – ongoing: $265,000+ services research relating to knowledge (Southern Health). translation and evidence based guideline development and implementation. Department of Health and Aging, Project Grant. Improving the use of diagnostic imaging in low back pain RESEARCH ACTIVITIES by general practitioners: a multifaceted intervention study. S.Goergen, R. Paediatric Imaging research platform. Sanson-Fisher (University of Newcastle). Professor Michael Ditchfield. 2007-2011: $293,970 (Royal Australian Prize winning presentation on new and New Zealand College of Dynamic CT technique of airway Radiologists). diseases in infants. NHMRC, Project Grant. Cancer and Collaborative landmark Dynamic low dose radiation. Possible effects CT assessment of Vocal Cord of CT scans in childhood. J. Mathews, Dysfunction work with Respiratory C. Kelman, S.Goergen, J. Dowty, G. Department and Toshiba. Byrnes, S. Darby. 2007-2011: $451,050. Associate Professor Stacy Goergen – Lead author for JACR Quality issue.
40 Southern Health Research Report 2010 41 RESEARCH GROUP REPORTS
Emergency Medicine
DIRECTOR: PROFESSOR GEORGE BRAITBERG
The Southern Health Emergency Medicine Research Group (SHERG) oversees the research program encompassing the three emergency departments of Monash Medical Centre Clayton, Dandenong Hospital and Casey Hospital Berwick as well as an academic emergency medicine research affiliation with Monash University.
There is an active clinical research program severe poisoning with fat-soluble drugs. Kalam Y, Graudins A. An assessment across the three Emergency Departments There is a paucity of data examining the of the efficacy of levosimendan in (EDs) with specific focus on the core mechanism of the effect that may result the treatment of severe metoprolol research interests of the network including in improvement in clinical toxicity. This poisoning in an in-vivo model of drug best-practice antiemetic and acute suggests that in part the effects may be toxicity. Levosimendan is a novel analgesia use in the ED, preventive health mediated by a reduction in free serum inotropic agent used in the treatment measures in emergency medicine, medical drug concentrations. of heart failure. This research suggests education of emergency medicine trainees, that levosimendan may have moderate point-of-care testing in the ED, as well as a Egerton-Warburton D, Povey K, Mee beneficial effects in severe beta-blocker specific toxicology research laboratory for M. A randomised controlled trial of poisoning and clinical trials may be in-vitro and in-vivo research in aspects of bolus versus fifteen-minute infusion warranted. applied and translational clinical toxicology. of Metoclopramide to determine the 2010 has been a productive year for incidence and severity of drug induced Markham D, Graudins A. An emergency medicine research at Southern akathisia. Metoclopramide is the assessment of the characteristics Health with an ever increasing number of most common antiemetic used for of adult frequent ED presenters to peer-reviewed publications, conference control of nausea and vomiting in the Southern Health EDs. Patients who presentations and trainee research project ED. This study showed no difference are recurrent attenders to the ED are presentations. in the incidence of side effects commonly more socially isolated between the two dosing regimens for and suffer with chronic physical and metoclopramide. mental health problems that may Completed projects not necessarily be best managed by Egerton-Warburton D, Braitberg G, recurrent presentation to the ED. This Craig S, Braitberg G, Nicolas C, White Nicolas C, Clarke M, the NHMRC G, Egerton-Warburton D. Clinical study has identified target groups that Emergency Care Pain Management may benefit from specific allied health supervision: Assessment and feedback Initiative Advisory Committee. in emergency medicine training: Views interventions to address the reasons for Implementation of Best Practice and reduce ED reattendances. of Australasian emergency trainees. Guidelines to Improve Emergency Craig S. Direct observation of clinical Department Pain Management: National practice in emergency medicine Institute of Clinical Studies (NICS) – education. Pain audit. The NICS audit evaluated the pain management practices within Dissanayake M, Doery J, Graudins A. the ED; highlighting specific areas An assessment of the in-vitro binding for improvement. The audit was also of anticonvulsants to intravenous lipid responsible for the implementation of emulsion in human pooled serum. necessary pain management programs Intravenous lipid emulsion has been such as Nurse Initiated Analgesia. suggested as a potential antidote to
42 Southern Health Research Report 2010 43 RESEARCH GROUP REPORTS Emergency Medicine
Marmor G, Braitberg G, Nicolas C. Braitberg G, Mosley I, Meek R, Bray J, Kalam Y, Graudins A. An assessment Medication and Therapeutic errors in Nicolas C. Pre-hospital Methoxyflurane of the efficacy of levosimendan in Emergency Departments (MATED): project. A retrospective review the treatment of severe propranolol A survey of medication prescribing, assessing the patterns of usage poisoning in an in-vivo model of drug surveillance and safety issues in and relative effectiveness of inhaled toxicity. Levosimendan is a novel Australian Emergency Departments. methoxyflurane in the pre-hospital inotropic agent used in the treatment This is the first study to evaluate management of pain in patients of heart failure. An assessment of its Fellows of the Australasian College transported to hospital by effectiveness in propranolol poisoning of Emergency Medicine (FACEMs’) Ambulance Victoria. is on-going following the observations prescribing practices in Australasian made with metoprolol poisoning. EDs. There are numerous prescribing Braitberg G, Mosley I, Nicolas C, Phan and medication safety practices and a T, Srikanth V, Bray J. Inter-rater reliability Markham D, Graudins A. The Complex lack of conformity amongst FACEMs; of stroke recognition and stroke Resource Intensive Patient (CRiP) despite the introduction of the National onset time. This study investigates Program. Development of specific care Inpatient Medication Chart (NIMC). stroke recognition and symptom plans targeting recurrent ED attending onset time identification across the patients with complex physical and Meek R, Nicolas C, Mahendraraviraj N. process of pre-hospital and ED care. psychosocial problems. This group may Primary care patients in the Emergency Assessments made by ambulance call benefit from targeted multidisciplinary Department: Reasons for attendance takers, paramedics, triage nurses, ED medical and allied health intervention and influences on likelihood to return. physicians and neurology physicians strategies that reduce ED attendances This study showed that primary will be investigated. The results of this and ensure patient needs are met in the care patients attend ED for different study will inform education programs appropriate healthcare setting. underlying reasons and are differently for health professionals on the influenced with regard to their likelihood assessment of acute stroke patients. Matera JT, Egerton-Warburton D, of return to ED with similar conditions Meek R. Ultrasound guidance for in the future. This may be important Braitberg G, Hood K, Mosley I, Nicolas central venous catheter placement in for hospitals planning interventions to C. Community stroke knowledge. A Australasian emergency departments. redirect their primary care patients away public health project to investigate McKay P, Craig S, Egerton-Warbuton from the ED. community stroke knowledge and the response of community members to D, Meyer A. NSAIDS in renal colic. To Meek R, Kwok G. Does use of an stroke symptom onset. Further analysis compare the efficacy of IM ketorolac, Accelerated Chest Pain Pathway has been undertaken to assess stroke oral ibuprofen and (the traditional) PR (ACCP) using Point of Care (POC) knowledge prior to and following indocid as analgesic agents for patients cardiac multimarkers improve global “Stroke Week”. This study will inform suffering from the clinical diagnosis of ED performance indicators? community awareness campaigns to renal colic. improve stroke awareness. Meek R. The paramedic collaboration Current projects Braitberg G, Howard M, Nicolas with triage (PACT) study. Aiming to improve patient safety at the ambulance C. Mentoring of Southern Health Arora S, Braitberg G, Kearley Y. A – ED interface. multi-centre, randomised controlled trial Emergency Medicine Junior Medical Staff. of early goal-directed therapy in patients Meek R, Tong R. The incidence of presenting to the ED with severe sepsis Egerton-Warburton D. A randomised- VTE in patients discharged from the in Australasia (A.R.I.S.E.). placebo controlled trial of antiemetic ED with below knee immobilisation for an isolated lower leg injury. This efficacy for nausea and vomiting in the Braitberg G, Mosley I, Meek R, Nicolas study will help establish whether or not C, Patsamanis H, Biuso C. Heart ED. This trial compares the efficacy of metoclopramide and ondansetron in thromboprophylaxis is warranted for ED Foundation campaign impact analysis: patients who are discharged from ED in The role of demographic factors on patients presenting with nausea and vomiting with the aim to determine a below knee cast for lower leg fracture ED chest pain presentations - pre or soft tissue injury. campaign (6 weeks), during campaign, the most effective antiemetic for use post campaign (3 months). A national in the ED. initiative aiming to evaluate the Egerton-Warburton D, Kroushev A. detection of acute coronary syndrome Vollenhoven B, Perera A. (i.e., early signs or symptoms of heart The prevalence of ovarian torsion: attack) within the ED. A retrospective audit.
42 Southern Health Research Report 2010 43 RESEARCH GROUP REPORTS Emergency Medicine
Meek R, Principal Investigator for the Mosley I, Braitberg G. HeartWatch Mosley I, Innis K, Morphet J, Bray J, PACT Study Group. The Paramedic campaign impact analysis: Analysis Braitberg G. The role of triage nurses in Collaboration with Triage (PACT) Study. and comparison of hospital facilitating acute stroke care protocols Aiming to improve patient safety at the presentation data for patients with chest in the ED. A retrospective study of triage ambulance – ED interface. This study pain - pre campaign (6 weeks), during assessments, problem identification investiges the possibility of paramedics campaign, post campaign (3 months). and triage codes allocated to acute triaging patients pre-arrival using Aim to assess if there is a subgroup that stroke patients who present to Southern the ATS in order to avoid re-triage at showed a particular response pattern/ Health EDs. This study will inform the hospital by a nurse. This may shorten increase in chest pain presentations development of education programs for ambulance patient transfer times and or admissions to hospital. This will be triage nurses. mean that only one verbal handover compared to data from the previous 2 to will be needed to treating staff. 3 years to compare seasonal variation. Oakley E. An on-going multi-centre randomised controlled trial comparing Meek R, Leonny S. Comparing visual Mosley I, Braitberg G, Bray J, Nicolas nasogastric and intravenous hydration reading of urine dipsticks with a urine C. Headache in acute stroke. in children with bronchiolitis (The CRIB chemical analyser Bayer Clinitek Status. This study examines patients with study). This is a three year trial with acute stroke presenting to the ED with second year of recruitment finished. Mellett T, Craig S. Training and severe headache by ambulance, the This trial aims to assess whether the supervision in bedside ultrasound: assessment of pre-hospital analgesia provision of nasogastric fluids for A cross-sectional study. administration by paramedics and the rehydration of children with bronchiolitis impact of analgesic administration on is as effective as intravenous Meyer A, Graudins A, Egerton- care in the ED setting. The results will administration of rehydration fluids. Warburton D, Meek R. An assessment assist in development of ambulance of three oral analgesic regimens policy and pre-hospital clinical care for moderate pain in adult patients guidelines for pain relief of patients in the emergency department. PUBLICATIONS, experiencing headache or migraine. This study is assessing the comparative POSTGRADUATE STUDENTS effectiveness of the addition of opioid Mosley I, Braitberg G. Recognition, AND FUNDING SUMMARY analgesia to paracetamol and response and organisation of acute Journal articles 19 non-steroidal anti-inflammatory stroke care in the community, agents in moderate pain in the ED. pre-hospital and emergency Book chapters 1 department settings. A prospective Meyer A, Thompson B. Children with observational study that aims to look Conference presentations 29 gastroenteritis. at ways to enhance stroke awareness Postgraduate research students 1 Meyer A. Casey aged care project. by exploring the recognition, response To devise a better method of managing and organisation of acute stroke acute medical issues in members of the among doctors, nurses and members Funding: aged community (>65 yrs), specifically of the general public. those who reside in residential aged Competitive Mosley I, Braitberg G, Bray J, Nicolas care facilities, in the City of Casey. C. Acute stroke “Ramp Time” delays. NHMRC, Project Grant. Randomised controlled trial comparing nasogastric Mosley I, Braitberg G, Meek R, Nicolas A retrospective study of delay times of and intravenous hydration in children C. An analysis of preferred language acute stroke patients who present by with bronchiolitis. Oakley E. 2010: and correlation to time from chest ambulance to Southern Health EDs. $303,000. 2009-2012: $851,850 pain symptom onset (delay), use of The focus of this study is the impact (Murdoch Institute). ambulance resources and admission of delays from triage assessment rate to the ED. to ED cubicle availability on the implementation of acute stroke rapid Other Mosley I, Braitberg G. Time of care protocols. This study will inform ED Monash University Strategic Grants presentation for patients with chest protocols to facilitate rapid stroke care Scheme, Project Grant. Recognition, pain - out of hours vs. in hours in an environment of ED overcrowding response and organisation of acute (Mon – Fri 8am to 6pm). Are people and increasing patient presentations by stroke care in the community, pre- less likely to present to emergency ambulance. hospital and emergency department in the middle of the night? Compare settings. Mosley I, Braitberg G. 2010: and contrast populations presenting $35,000 (Monash University). ‘in-hours’ and ‘out of hours’. An analysis of HeartWatch survey data assessing what people reported as their ‘intended action’ if experiencing chest pain or warning signs ‘in and out of hours’.
44 Southern Health Research Report 2010 45 RESEARCH GROUP REPORTS
Endocrinology
DIRECTOR: PROFESSOR PETER FULLER
The Department of Endocrinology was originally established at Prince Henry’s Hospital in 1968.
It was also closely aligned with the Endocrine Oncology Menopausal Medicine Medical Research Centre at Prince Henry’s Hospital. Both organisations The unit has an active program of research The unit has over the years made major were directed by Professor Henry Burger on the molecular basis of thyroid cancer contributions to the development of the for some 30 years. During that time over together with an engagement of local and management of menopause, particularly 40 endocrinologists have been trained national initiatives around the collection with respect to the endocrinology of the through the unit, many of whom now head of tissue, databases and clinical trials menopausal transition. The members endocrinology units around the country. capacity. The unit played a prominent of the unit have projects examining Under Professor Burger’s leadership it role in the development of the current management issues in women with breast became the pre-eminent endocrinology guidelines for the treatment of thyroid cancer and in premature menopause. unit in Australia. Some 10 years ago the cancer. The unit has a long standing endocrinology and diabetes functions involvement in the endocrine aspects of breast cancer. In addition, there is active Osteoporosis and Metabolic were separated in acknowledgement of Bone Disease the large expansion in the service research on aspects of ovarian cancer, demands associated with provision of particularly granulosa cell tumours of In 2009, the unit launched the diabetes services. the ovary. A number of the latter studies Osteoporosis and Secondary Prevention follow from the ground breaking work of Project which is being lead by Dr Francis Professor Peter Fuller was awarded Professor Henry Burger and colleagues in Milat. Associated with the development the 2011 Society for Endocrinology discovering the hormone ‘inhibin’. of service delivery will be research into Hoffenberg International Medal of the osteoporosis both in respect to patterns British Endocrine Society in 2010. Molecular Endocrinology of service delivery and management as well as into specific areas such as in Other work has focussed on the action males, in patients with thalassaemia RESEARCH ACTIVITIES of the adrenal steroid hormones and in women after breast cancer (aldosterone and cortisol), with particular treatment. This research crosses from Reproductive Endocrinology emphasis on aldosterone. There is bench to bedside with parallel laboratory emerging evidence for an important role and clinical research activities. Studies of male fertility and infertility, as of aldosterone and cardiovascular disease well as the role of androgens in healthy and the benefits of therapeutic blockade. aging males. More recently the unit is This is an active subject for investigation PUBLICATIONS, AWARDS, developing programs around the problems as well as the development of guidelines POSTGRADUATE STUDENTS of androgen deprivation in men with for the management of primary prostate cancer. Research in female hyperaldosteronism. AND FUNDING SUMMARY reproductive endocrinology has focused Journal articles 15 on breast cancer, the menopause and polycystic ovarian syndrome. Book chapters 2
Conference presentations 11
Awards 1
Postgraduate research students 3
44 Southern Health Research Report 2010 45 RESEARCH GROUP REPORTS Endocrinology
Funding: Cancer Council of Victoria, Project Grant. Molecular pathogenesis of granulosa cell Competitive tumours of the ovary. Peter Fuller. 2010: MBF Research Foundation / ANZAC $100,000. 2010-2011: $200,000 (PHI). Institute, cost reimbursement. The National Heart Foundation, Grant in Healthy Man Study-Development of a aid. Identification of ligand-discriminant valid diagnostic criteria for age-related interactions of the mineralocorticoid androgen deficiency in men. Robert receptor. Peter Fuller. 2010: $64,500. McLachlan. 2010: $Nil. 2008-present: 2010-2011: $125,000 (PHI). $85,935 (PHI). NABO-Ovarian Cancer Research
WHO-CONRAD, Clinical Agreement. Foundation, Project Grant. Support Sperm suppression and contraceptive of granulosa cell tumour of the ovary protection provided by Norethisterone research program. Peter Fuller. 2010: (NET-EN) and Testosterone Undecanoate $137,500. 2009-2010: $240,000 (PHI). (TU) in Healthy Men. Robert McLachlan. 2010: US$102,045. 2008-2010: Melbourne budget $US205,000 (PHI).
NHMRC, Project Grant. Mineralocorticoid receptor coregulator recruitment determines ligand-specific signalling. Peter Fuller. 2010: $174,582. 2008-2010: $491,530 (PHI).
NHMRC, Project Grant. Why we have two estrogen receptors: the role of ERbeta in folliculogenesis. Peter Fuller. 2010: $195,806. 2008-2010: $572,404 (PHI).
NHMRC, Project Grant. Macrophage mineralocorticoid receptor signalling regulars cardiovascular remodelling and systolic blood pressure. Peter Fuller. 2010: $139,780. 2009-2011: $419,531 (PHI).
NHMRC, Senior Principal Research Fellowship. Peter Fuller. 2010 $171,161. 2006-2010 $823,250 (PHI).
National Breast Cancer Foundation, Collaborative Program Grant. Identification of nuclear receptor networks as new targets for breast cancer. Peter Fuller, Christine Clarke, Wayne Tilley, Peter Leedman, George Muscat, John W Funder, Mark Ragan, Evan R Simpson and Nadia Rosenthal. 5 Years: $1,000,000 (PHI).
46 Southern Health Research Report 2010 47 RESEARCH GROUP REPORTS
Gastrointestinal and Hepatology
DIRECTOR: PROFESSOR WILLIAM SIEVERT
Current research programs in the Gastroenterology and Hepatology Unit involve clinical trials of viral hepatitis therapy, basic mechanisms and treatment of liver fibrosis, the use of stem-like cells for hepatocyte transplantation, the host immune response in Hepatitis B Virus infection, endoscopic outcomes research and inflammatory bowel disease therapy.
The unit has been involved in over 90 RESEARCH ACHIEVEMENTS A Phase 2B Study of BMS-790052 clinical trials of novel agents for the in Combination with Peginterferon treatment of chronic viral hepatitis and IN 2010 Alfa-2a and Ribavirin in Treatment hepatocellular carcinoma, including the Providing proof of concept that Naïve Subjects with Chronic Hepatitis initiation and development of clinical trial xenotransplantation of human amnion C Genotype 2 or 3. Investigator: protocols for national studies while also epithelial cells reduces murine hepatic Sievert. Sponsor: BMS participating in multi-centre international fibrosis. trials. In addition to therapy, studies in A randomised, open label, phase 3 collaboration with LaTrobe University have Demonstrating the efficacy and safety study of telaprevir administered twice focused on access to health services of a single session of argon plasma daily or every 8 hours in combination for patients from ethnic communities coagulation for the treatment of with pegylated interferon alfa-2a and and the quality of service provision. radiation proctitis. ribavirin in treatment-naïve subjects Basic hepatology research has focused with genotype 1 chronic hepatitis C
on mechanisms of liver fibrosis with Collaborating with MIMR scientists virus infection. Telaprevir Naïve Study. investigators from the Monash Institute of to complete a study characterising Investigator: Sievert. Sponsor: Medical Research, University of Melbourne the role of innate immunity in gastric Jansen Cilag and the Monash University Centre for carcinogenesis. A randomised, double-blind, placebo- Inflammatory Diseases, with whom we also controlled trial of the efficacy and safety collaborate on studies of the host immune of DEB025/Alisporivir in combination response in hepatitis B infection. RESEARCH ACTIVITIES with standard of care in hepatitis C These studies, supported in part by the A Phase 2B, randomised study to genotype 1 treatment-naïve patients. NHMRC and by funds from diagnostic evaluate the safety and efficacy of Investigator: Pianko. Sponsor: Novartis breath testing, have led to three successful Pegylated Interferon Lambda (BMS- Dose-Ranging Study to Evaluate the PhD completions. Endoscopic outcomes 914143) administered with Ribavirin Safety, Efficacy and Pharmacokinetics are a significant focus of unit research plus a single direct antiviral agent of Pegylated Interferon Lambda (BMS- pursuits because these activities directly (BMS-790052 or BMS-650032) versus 914143) Monotherapy in Interferon- affect patient outcomes. A scientific Pegasys administered with Ribavirin Naïve Patients with Chronic Hepatitis B approach to the development and (Part A) and of Pegylated Interferon Virus Infection who are HBeAg-positive. evaluation of therapeutic endoscopy Lambda (BMS-914143) administered Investigator: Sievert. Sponsor: BMS is fostered by contributions to national with or without Ribavirin plus 2 direct antiviral agents (BMS 790052 and scientific meetings in combination with A multicenter, randomized, open BMS-650032) (Part B) in chronic a training program to assist young label, parallel-group phase IIB study on hepatitis C genotype-1 treatment gastroenterologists to think critically about the efficacy and safety of oral regimens naïve subjects. Investigator: Sievert. the outcome of endoscopic procedures. of DEB025 alone or in combination with Sponsor: BMS More recently, the unit has become ribavirin versus Standard of Care (peg- involved in clinical trials evaluating novel IFN alpha-2a plus ribavirin) in treatment- treatments for patients with inflammatory naïve hepatitis C genotype 2 and 3 bowel disease. patients. Pianko. Sponsor: Novartis
46 Southern Health Research Report 2010 47 RESEARCH GROUP REPORTS Gastrointestinal and Hepatology
A randomized, open-label, controlled, Combination with Standard of Care A Phase 2B, Multi-Centre, Randomized, multi-centre pilot study evaluating the (SOC) for 12 weeks in a Population Double-Blind, Parallel Group, efficacy and safety of Tenofovir 300 mg of Relapsed HCV-1 Infected Subjects. Placebo-Controlled, Dose Ranging PO in combination with peginterferon Investigator: Pianko. Sponsor: Novartis Study Comparing the Efficacy, Safety, alpha-2a sc 180 µg for 48 weeks in and pharmacokinetics of Intravenous patients with HBeAg-positive CHB. A Randomized, Open-Label, Multicenter Infusions of ABT-874 vs. Placebo in Investigator: Dev. Study Examining the Effects of 24 Subjects with Moderately to Severely Versus 48 Weeks of Combination Active Crohn’s Disease. Investigator: A Phase 2b Study of BMS-790052 in Therapy with PEGASYS® (Peginterferon Moore. Sponsor: Abbott Combination with PegInterferon Alfa-2a alfa-2a 40KD) plus COPEGUS® and Ribavirin in Chronic Hepatitis C (Ribavirin) on Sustained Virological A Phase 3, Open-label Study to Genotype 1 Infected Subjects Who Response in Patients with Chronic Determine the Long-term Safety and are Null or Partial Responders to Hepatitis C, Genotype 2 or 3 who do Efficacy of MLN0002 in Patients with Prior Treatment with Peginterferon Alfa not Achieve a Rapid Viral Response. Ulcerative Colitis (UC) and Crohn’s plus Ribavirin Therapy. Investigator: Investigator: Pianko. Sponsor: Roche Disease (CD) (Gemini III - Millennium). Sievert. Sponsor: BMS Investigator: Moore. Sponsor: A phase II randomized, double-blind, Millennium A multicentre, randomized, placebo-controlled study of sorafenib or double-blind, placebo-controlled, placebo in combination with transarterial A Phase 3, Randomized, parallel-group phase II study on chemoembolization (TACE) performed Placebo-Controlled, Blinded, Multicenter the efficacy and safety of DEB025 with DC Bead and doxorubicin for Study of the Induction and Maintenance combined with peg-IFN alfa-2a and intermediate stage hepatocellular of Clinical Response and Remission ribavirin in chronic hepatitis C genotype carcinoma SPACE. Investigator: Sievert. by MLN0002 in Patients with Moderate 1 patients who are previous peg-IFN Sponsor: Bayer to Severe Crohn’s Disease (Gemini alfa-2 plus ribavirin treatment-non- II- Millennium). Investigator: Moore. responders. Investigator: Pianko. Antiviral effect, safety and Sponsor: Millennium Sponsor: Novartis pharmacokinetics of once daily BI 201335 NA in hepatitis C virus genotype A Phase 3, Randomized, A Phase 2b Study of BMS-790052 1 infected treatment-naïve patients for Placebo-Controlled, Blinded, in Combination with Peg-Interferon 24 weeks as combination therapy with Multicenter Study of the Induction and Alfa-2a and Ribavirin in Treatment pegylated interferon-α 2a and Ribavirin Maintenance of Clinical Response and Naïve Subjects with Chronic Hepatitis (double-blinded, randomised, placebo- Remission by MLN0002 in Patients with C Genotype 1 and 4 Infection. controlled, Phase II). Investigator: Moderate to Severe Ulcerative Colitis Investigator: Sievert. Sponsor: Sievert. Sponsor: Boehringer Ingelheim. (Gemini I - Millennium). Investigator: Bristol Myers Squib Moore. Sponsor: Millennium Comparative Study of Chronic Hepatitis An open-label, single-arm, roll-over B Subjects Treated with Entecavir Plus trial of telaprevir in combination with Tenofovir Combination Therapy vs PUBLICATIONS, pegylated interferon alfa-2a (Pegylated Entecavir Monotherapy in Adults who Interferon) and ribavirin (Copegus®) are Treatment Naïve to Nucleosides POSTGRADUATE STUDENTS for subjects from the control group and Nucleotides: (The BELOW Study). AND FUNDING SUMMARY of the VX-950-TiDP24-C216 trial who Investigator: Sievert. Sponsor: Bristol Journal articles 7 failed therapy for virologic reasons. Myers Squib Investigator: Sievert. Sponsor: Conference presentations 20 Jansen Cilag Double-blind, dose-response, randomised, placebo-controlled, Postgraduate research students 3 A Phase III randomized, placebo parallel group, multi-centre phase controlled, double blind trial of III clinical study on the efficacy and Sorafenib plus Erlotinib vs. Sorafenib tolerability of mesalazine granules vs. Funding: plus placebo as First Line systemic placebo for the prevention of Competitive treatment for Hepatocellular recurrence of diverticulitis. Investigator: Carcinoma (HCC). Investigator: Moore. Sponsor: Falk Pharma NHMRC, Project grant. Role of Sievert. Sponsor: Bayer Human Amnion Epithelial Cells POCER Study – Post-Operative Crohn’s in Resolving Hepatic Fibrosis. A Randomized, Active-Controlled, Disease Recurrence: Endoscopic U Manuelpillai, W Sievert. 2010 – 2012: Adaptive-Design Dose Finding study Guided Intervention & Determination of $596,500 (Monash University). to assess the Antiviral Efficacy and Cause. Investigator: Moore. Sponsor: Safety of NIM811 Administered in Investigator Commercial See above.
48 Southern Health Research Report 2010 49 RESEARCH GROUP REPORTS
Haematology
CLINICAL DIRECTOR: ASSOCIATE PROFESSOR STEPHEN OPAT
The Clinical Haematology Department cares for patients with blood-related disorders including cancers, clotting and bleeding disorders, and pregnancy-related haematological complications.
The unit comprises consultant Associate Professor Stephen Opat Haematology Society of Australia haematologists, advanced trainees continues to explore the potential & New Zealand, Young Investigator (registrars), a research fellow and research clinical utility of biomarkers in Scholarship. Understanding how coordinators. This is supported by a busy non-Hodgkin lymphoma. Dr Hang the loss of NFκB1 function promotes haemato-pathology service. In addition Quach completed her Doctorate of the development of T-cell neoplasms. to routine clinical work, the department Medicine: “The clinical role of biological Grigoriadis G. 2010: $50,000 conducts numerous clinical trials. agents in the treatment of multiple (2009-2010). myeloma and the in vivo immunological effects of iMIDs in myeloma”. Both have Commercial continued with their roles as principal RESEARCH ACTIVITIES Alexion Australia investigator in several clinical trials for Associate Professor Eng Gan, Dr Huyen myeloma and lymphoma that aim to Amgen Tran and Dr Sanjeev Chunilal share a evaluate the efficacy and safety of novel strong interest in venous thrombosis and therapeutic agents. Several unit members Boehringer Ingelheim continue to participate in the conduct of (Dr Andrew Wei, Dr Briony Cutts and Dr Covance numerous clinical trials involving the use George Grigoriadis) were successful in of new anticoagulants to treat and prevent obtaining fellowship and project grants, Hokusai thrombosis. Compared with vitamin K which will enable them to further their antagonists such as warfarin, these research interests. Novartis oral drugs have superior pharmacologic properties with minimal food or Orion drug-to-drug interaction and require no PUBLICATIONS AND Pfizer monitoring. The demonstrated non-inferior FUNDING SUMMARY or superior efficacy with similar safety PPD compared with warfarin will improve upon Journal articles 27 the current standard of care for patients Quintiles afflicted by venous thrombosis. Conference presentations 35 Roche
Funding: Trident for Incyte
Competitive University of Sydney Haematology Society of Australia & New Zealand, Young Investigator Patents: Scholarship. Pre-test probability Stimulating immune response. Shortt J, models, biomarkers and imaging in Hsu A, Johnstone R, Neeson P, Ritchie diagnosis of venous thromboembolism D, McArthur G. Peter MacCallum Cancer in pregnancy. Cutts B. 2010-2011: Institute, year issued 2010. Patent number: $50,000. 2010902717 (Australia).
48 Southern Health Research Report 2010 49 RESEARCH GROUP REPORTS
Infectious Diseases and Microbiology
DIRECTOR: DR TONY KORMAN
The Department of Infectious Diseases and Microbiology provides a broad range of clinical services including an inpatient unit, a busy consultation service, intensive care service, hospital in the home intravenous antibiotic therapy, and outpatient clinics (including refugee health, mycobacterial infections and HIV/AIDS), in addition to infection control, clinical microbiology laboratory, antimicrobial management service, research and teaching activities.
The establishment of the Innate Immunity RESEARCH HIGHLIGHTS Early Immune Responses to Laboratory lead by Kumar Visvanathan Mycobacterium ulcerans: Grant Jenkin, in the Centre for Inflammatory Diseases, IN 2010 Vesna Markovska, Tim Stinnear and Department of Medicine, Southern Sabine De Silva was awarded a Kumar Visvanathan Clinical School, Monash University prestigious NHMRC postgraduate Measuring adequate treatment now provides our department with medical scholarship, in addition to a responses to TB: Sabine de Silva, the opportunity to use basic science Southern Health/Monash University Grant Jenkin, Vesna Markovska and techniques to augment and support Academic training fellowship. Sabine Kumar Visvanathan clinical research in Infectious Diseases. will be commencing a PhD investigating immunological mechanisms in Recent highlights include a number of Longitudinal changes to the immune tuberculosis under the supervision of grants for the innate immune laboratory response in moderate to severe sepsis: Associate Professor Kumar Visvanathan including a NHMRC grant in Hepatitis, Chris Wright (ICU), Jay Achar, Narelle and Dr Grant Jenkin. a grant from the Australian Centre for Skinner and Kumar Visvanathan Hepatitis and HIV as well as a grant David Sheffield was invited to speak at The role of Vitamin D in response to shared with the renal department from the “Infection and Disease” symposium infection: Sam Ojami, Narelle Skinner, the transplantation society of Australia at the 5th Australian Health & Medical Ian Woolley Kumar Visvanathan and New Zealand, a number of major Research Congress 2010. publications involving, mycobacterium ulcerans, innate immune responses in Ian Woolley won the Henry Burger PUBLICATIONS, AWARDS, Hepatitis B infection and splenectomy. Prize for Clinical Research (Southern Health Senior Medical Staff) in 2010. POSTGRADUATE STUDENTS AND FUNDING SUMMARY Current projects Journal articles 25 Immunological Function post splenectomy: Ian Woolley, Denis Book chapters 16 Spellman Conference presentations 14 Innate Immunity of HBV infection: Narelle Skinner and Kumar Awards 1 Visvanathan Postgraduate research students 1 HBV and Pregnancy: Michelle Giles and Kumar Visvanathan
50 Southern Health Research Report 2010 51 RESEARCH GROUP REPORTS Infectious Diseases and Microbiology
Funding:
Competitive The foundation for AIDS research amFAR. Australian HIV Observational Database. Woolley, IJ, Giles, M. 2010: 2,000.00. 1999-ongoing (National Centre for HIV).
NHMRC, Flu Grant. Flucan. Korman, T. 2010: $50,000 (2009-2010 Australian National University).
NHMRC, Flu Grant. H1N1 Development of a signature for early responses to influenza strains that determine / correlate with severity of infection. Visvanathan K. 2010: $240,000 (2009-2010 Monash University).
Breast Cancer Research Foundation, Project Grant. Mechanisms of cancer susceptibility among BRCA1/2 mutation carriers. Visvanathan K. 2010: $60,000. 2010-2011: $120,000 (Johns Hopkins).
Commercial A phase 3, open-label, randomised study of the antiviral activity, safety, and tolerability of intravenous peramivir in hospitalised subjects with confirmed or suspected influenza infection. Sponsor: BioCryst Pharaceuticals. Principal investigator: Korman, T (Southern Health).
50 Southern Health Research Report 2010 51 RESEARCH GROUP REPORTS
Infection Control and Epidemiology
UNIT CO-DIRECTORS: DR RHONDA STUART AND MS ELIZABETH GILLESPIE
The Infection Control and Epidemiology unit are constantly looking for new innovations to promote and enhance safe and effective patient care associated with infection control. The unit covers five major sites and community centres.
RESEARCH ACTIVITIES
In 2010 an antibiotic stewardship program (Switch to oral) commenced for nurses involving a pilot study in three wards at Monash Medical Centre and three wards at Dandenong Hospital. The pilot study initially demonstrated that involving nurses increased nursing knowledge about appropriate antibiotic use – its strength and weaknesses.
This pilot is continuing into 2011 to now examine whether involving nurses is able to impact on IV antibiotic use and switch to oral use. A progress report was presented at the Australian Infection Control Association National conference in Perth in October 2010 by Anne Rodrigues. Southern Health was the successful winner of a scholarship worth $15,000 in 2009 to undertaken this pilot study.
PUBLICATIONS SUMMARY
Journal articles 8
Book chapters 4
Conference presentations 5
52 Southern Health Research Report 2010 53 RESEARCH GROUP REPORTS
Intensive Care
UNIT DIRECTOR: DR CRAIG WALKER – MONASH MEDICAL CENTRE, CLAYTON
UNIT DIRECTOR: DR YVONNE KEARLEY – DANDENONG HOSPITAL
MONASH MEDICAL CENTRE, RESEARCH PROJECTS Prowess-Shock Study: A randomised, double-blind, CLAYTON placebo-controlled, multicentre, phase The Intensive Care Unit at Monash Medical Monash Medical Centre, 3 study of Drotrecogin Alfa (activated) Centre is a large 21 bed unit. It has a broad Clayton administered as a continuous 96-hour infusion to adult patients with case mix including cardiothoracic and The Early PN study: septic shock. Principal investigator: neurosurgery and is one of the only units Early parenteral nutrition versus Dr Tim Crozier, study not yet completed. to look after obstetric patients. Monash standard care in the critically ill patient: Medical Centre is also the only tertiary An ANZICS CTG endorsed level 1 The Volume Responsive Study: unit to provide advanced life support to randomised controlled trial. Principal A prospective observational study critically ill adults and children. It provides Investigator: Dr Tim Crozier (study of volume responsiveness’ in the academic support to both medical and continuing in 2011). critically ill. (Completed February 2010). nursing staff, in addition the unit welcomes Principal Investigator: Dr Tim Crozier and fosters trainees from all backgrounds The Protect Study: and has a strong emphasis on teaching Prophylaxis of thromboembolism in Conscious 3 Study: and research. critical care trial. Principal Investigator: A prospective, multi-center, double- Dr Tim Crozier (study completed blind, randomized, placebo-controlled, March 2010) parallel-group study to assess the DANDENONG efficacy and safety of clazosentan in Statins Study: reducing vasospasm-related morbidity Dandenong Intensive Care Unit is a 14 A phase II randomised controlled trial and all-cause mortality in adult patients bed major metropolitan unit providing of atorvastatin therapy in intensive care with aneurysmal subarachnoid intensive care and high dependency care patients with severe sepsis. Trial phase: hemorrhage treated by endovascular to more than 1200 patients per annum. II. Principal Investigator: Dr Craig Walker coiling. Principal investigator: Dr Craig Dandenong ICU is accredited by the This study completed in 2010, results Walker. Study abandoned in 2010 College of Intensive Care Medicine for will be known in March 2011. following results of Consciou2 study. training in intensive care as well as for ART-123: the necessary and mutually recognised Renal Citrate Study: A randomised, double-blind, component of other specialty training A randomised controlled study of two placebo-controlled, phase 2b study to programmes. A research coordinator different anticoagulation regimens assess the safety and efficacy effects position continues to receive funding (citrate vs heparin) on filter life during of ART-123 on subjects with sepsis and allowing participation in various research continuous venovenous haemofiltration disseminated intravascular coagulation. and quality activities within the ICU. (CVVHDF). Principal Investigator: Principal Investigator: Dr Craig Walker, Research projects in 2010 have been Dr Craig Walker. in collaboration with professional study completed in 2010, results not organisations such as ANZICS Clinical known as yet. The DARE Study: Discharge and readmission evaluation. Trials Group and independent commercial DORINOS3008: (Completed February 2010). Principal sponsors. The research projects have Phase 3:A prospective, randomised, Investigator: A/Prof Chris Wright. been supervised by senior medical staff double blind, double dummy, and supported by the Director of Intensive multicentre study to assess the safety Hep B in pregnancy Study: Care along with the support of all medical and efficacy of doripenem compared Following pregnant women who and nursing staff. with imipenem in the treatment of are Hep B positive, also looking at subjects with ventilator associated transmission rates to the baby. pheumonia. (Closed out May 2010) Principal Investigator: Dr Michelle Giles, Principal Investigator: Dr Craig Walker. study continuing in 2011.
52 Southern Health Research Report 2010 53 RESEARCH GROUP REPORTS Intensive Care
Infinite Study: Dandenong Peramivir Study. ANZICS CTG study flu study. Sponsor: Bio Cryst. Dr Tony Korman
Completed December 2010. The Early PN study: Early parenteral (Southern Health). nutrition versus standard care in the Influenza Study: critically ill patient: An ANZICS CTG Dorinos3008. Peramivir study: Pharmaceutical study endorsed level 1 randomised controlled Sponsor: Janssen-Cilag. Dr Craig looking at a new anti-viral drug for trial. Principal Investigator: Dr Tim Walker. 2010: $2,200 (Southern Health). the flu. Principal Investigator: Dr Tony Crozier (study continuing in 2011) Korman. ART-123. The Protect Study: Prophylaxis of Sponsor: Omnicare. Dr Craig Walker FluCAN: thromboembolism in critical care trial. & Dr Subhash Arora. 2010: $9,151 Observational flu study (NHMRC grant). Principal Investigator: Dr Tim Crozier (Southern Health). (study completed March 2010). Post Renal Study: Early PN. Prolonged renal outcome study. Statins Study: A phase II randomised Sponsor: ANZICS CTG. Principal investigator: Dr Craig Walker. controlled trial of atorvastatin therapy Dr Tim Crozier & Dr Subhash Arora. in intensive care patients with severe 2010: $11,115 (Southern Health). FluCAN: sepsis trial, phase II. Principal Observational flu study (NHMRC grant). Investigator: Dr Craig Walker. This FluCan. Principal Investigator: Dr Tony Korman. study completed in 2010, results will Sponsor: ARC/NHMRC. Dr Tony be known in March 2011. Korman. 2010: $39,540 (Monash Cyto-Fab Study: University). A multicenter, randomised, double- ART-123: A randomised, double-blind, blind, placebo-controlled phase IIb placebo-controlled, phase 2b study to Protect Study. study to compare the efficacy and assess the safety and efficacy effects Sponsor: ANZICS CTG. Dr Tim Crozier safety of two or three dosing regimens of ART-123 on subjects with sepsis and & Dr Subhash Arora. 2010: $31,352 of intravenous infusions of CytoFab™ disseminated intravascular coagulation. (Southern Health). (AZD9773) in adult patients with Principal Investigator: Dr Craig Walker, ARISE Study. severe sepsis. Principal investigator: study completed in 2010, results not Sponsor: ANZICS CTG. Dr David Dr Craig Walker. known as yet. Lightfoot & Dr Sanjiv Vij. Dori Study: Infinite study: ANZICS CTG study flu 2010: $3,068 (Southern Health). A prospective, randomised, double study. Completed December 2010. blind, double dummy, multicentre study Volume Responsive Study. to assess the safety and efficacy of MET – DOSE study – ANZICS CORE. Sponsor: Applied Physiology. doripenem compared with imipenem in Dr Tim Crozier. 2010: $3,564
the treatment of subjects with ventilator Point prevalence study. (Southern Health). associated pneumonia. Phase 3. IMPROVE-ICU: Multicenter study one Infinite Study. Principal Investigator: Dr Craig Walker. day prevalence observational study for Sponsor: ANZICS CTG. Dr Craig Visceral fat study in pancreatitis. delirium on ICU. Walker & Dr Subhash Arora. 2010: Principal investigator: $844 (Southern Health). Dr David Brewster. PUBLICATIONS AND MET DOSE Study. Obstetric workload audit. Principal FUNDING SUMMARY Sponsor: ANZICS CORE. Dr Yvonne Investigator: Dr Tim Crozier. Kearley. 2010: $600 (Southern Health). Journal articles 1 Safety of isotonic bicarbonate in the Point Prevalence Programme. Intensive Care Unit. Book chapters 1 Sponsor: ANZICS CTG. K. Shepherd/ B. O’Bree (Southern Health). Met calls and biochemistry Funding: IMPROVE-ICU. VF arrest audit Dr Yvonne Kearley (Southern Health). Commercial Conscious 3 study. Other Sponsor: Actelion. Dr Craig Walker. Hep B Study. 2010: $71,820 (Southern Health). Dr Michelle Giles. 2010: $13,899 (Monash University). Prowess. Sponsor: Parexel. Dr Tim Crozier. 2010: $308 (Southern Health).
54 Southern Health Research Report 2010 55 RESEARCH GROUP REPORTS
Medical Oncology
UNIT HEAD: DR PETER BRIGGS
The Medical Oncology Department is part of the Monash Medical Centre based at Moorabbin.
The department provides a comprehensive RESEARCH ACTIVITIES A randomized, multi-centre, open label clinical service in medical oncology with Phase 3 study of gemcitabine-cisplatin inpatients, outpatients and chemotherapy Randomized, double blind, chemotherapy plus IMC-11F8 versus units at both Dandenong Hospital and multi-centre Phase 2 study to estimate gemcitabine-cisplatin chemotherapy the Moorabbin site. A consultation service the efficacy and evaluate the safety and alone in the first line treatment of is provided to Monash Cancer Centre tolerability of cisplatin & capecitabine in patients with squamous stage IIIB Clayton and phase one trial treatments combination with AMG 386 or placebo or IV non small cell lung cancer. are administered at the Clayton site. in subjects with metastatic gastric, Principal Investigator: Dr Peter Briggs. Our research focus is on clinical research gastroesophageal junction, or distal
involving new therapeutics and supportive esophageal adenocarcinoma. Principal An international multi-centre open care at Phases 1, 2 and 3 of development. Investigator: Dr Andrew Strickland. label 2 arm phase III trial of adjuvant A translational research program is bevacizumab in triple negative also conducted in collaboration with A randomized phase II study breast cancer. Principal Investigator: researchers based particularly at evaluating weekly docetaxel, cisplatin, Dr Michelle White. Monash Institute of Medical Research fluoropyrimidine plus or minus A multi-centre, randomized, and Monash University Clayton. panitumumab in advanced oesophago-gastric cancer. Principal double-blind, placebo controlled, Investigator: Dr Andrew Strickland. phase III study of single-agent tarceva® (erlotinib) following complete RESEARCH ACHIEVEMENTS A randomized comparative study tumour resection with or without IN 2010 of FOLFOX6m plus SIR-SPHERES® adjuvant chemotherapy in patients versus FOLFOX6 alone as first with stage IB-IIIA non-small cell lung Presentation and publication of further line treatment in patients with carcinoma who have EGFR-positive outcome data from SETUP trial of non-resectable liver metastases tumours. Principal Investigator: neoadjuvant chemotherapy in locally from primary colorectal carcinoma. Dr Peter Briggs. advanced breast cancer. Principal Investigator: Dr Andrew Cardiac monitoring with echo (TDI) Commencement of new local Strickland. and serum biomarkers to assess investigator instigated translational A randomized, multi-centre, for cardiotoxicity with anthracyclines in studies in several tumour streams. open label Phase 3 study of women during adjuvant chemotherapy. Record number of new patients pemetrexed-cisplatin chemotherapy Principal Investigator: Dr Michelle White. plus IMC-11F8 versus pemetrexed- entered onto clinical trials. cisplatin chemotherapy alone in A randomized, double-blind, the first line treatment of patients placebo-controlled study of the with non squamous stage IIIB or IV efficacy and safety of MORAb-00. non small cell lung cancer. Principal (farletuzumab) in combination with Investigator: Dr Peter Briggs. paclitaxel therapy in subjects with first platinum-resistant or refractory relapsed ovarian cancer. Principal Investigator: Dr Geraldine Goss.
54 Southern Health Research Report 2010 55 RESEARCH GROUP REPORTS Medical Oncology
A Phase III open label, randomized, 2 A randomized, multicenter Phase A randomized, multi centre, open label, arm study of ixabepilone administered IIIb,open-label, study of letrozole vs phase III study of adjuvant lapatinib, every 21 days versus paclitaxel or anastrozole in the adjuvant treatment trastuzumab, their sequence and their doxorubicin administered every 21 days of postmenopausal women with combination in patients with HER2/ in women with advanced endometrial hormone receptor and node positive ErbB2 positive primary breast cancer. cancer who have previously been breast cancer. Principal Investigator: Principal Investigator: Dr Michelle White. treated with chemotherapy. Principal Dr Michelle White. Investigator: Dr Geraldine Goss. A randomized Phase III, double-blind, A Phase III trial evaluating the role placebo-controlled multicenter trial A randomized phase III study of of ovarian function suppression and of daily everolimus in combination weekly ABI-007 plus gemcitabine the role of exemestane as adjuvant with trastuzumab and vinorelbine, in versus gemcitabine alone in patients therapies for premenopausal women pretreated women with HER2/neu with metastatic adenocarcinoma of the with endocrine responsive breast over-expressing locally advanced or pancreas. Principal Investigator: cancer. Principal Investigator: metastatic breast cancer. Principal Dr Marion Harris. Dr Michelle White. Investigator: Dr Michelle White.
A randomized, double-blinded, A Phase III trial of LHRH analogue A randomized phase III, double-blind, multi-center phase III study comparing administration during chemotherapy placebo-controlled multicenter trial everolimus (RAD001) plus BSC to reduce ovarian failure following of everolimus in combination with versus placebo plus BSC in patients chemotherapy in early stage, trastuzumab and paclitaxel, as first with advanced gastric cancer after hormone-receptor negative breast line therapy in women with HER2 progression on prior systemic cancer. Principal Investigator: positive locally advanced or metastatic chemotherapy. Principal Investigator: Dr Michelle White. breast cancer. Principal Investigator: Dr Andrew Strickland. Dr Michelle White. Neoadjuvant chemotherapy with Vengeance: Dual targeting of vascular docetaxel and anthracycline based A randomized, double-blind, endothelial growth factor-A together with chemotherapy in patients with placebo-controlled, multi-centre angiopoietins in chemotherapy-naïve advanced breast cancer: Evaluation Phase 3 study of denosumab as metastatic colorectal cancer. Principal of biological, clinical and imaging adjuvant treatment for women with Investigator: Dr Andrew Strickland. markers of tumour response: A early stage breast cancer at high pilot study (“SETUP” trial). Principal risk of recurrence (D-Care). Principal A Phase 1B multiple ascending Investigator: Dr Vinod Ganju. Investigator: Dr Michelle White. dose study to evaluate the safety, pharmacokinetics and A phase 3 randomized study of Phase II randomized, double blind, pharmacodynamics of BMS-833923 (XL brivanib alaninate (BMS-582664) in multi centre study to assess the 139) in combination with carboplatin combination with cetuximab (Erbitux™, efficacy of AZD2281 in the treatment and etoposide followed by BMS-833923 C225) in patients previously treated of patients with platinum sensitive alone in subjects with extensive- with combination chemotherapy for serous ovarian cancer following stage small cell lung cancer. Principal metastatic colorectal carcinoma. treatment with two or more platinum Investigator: Dr Jason Lickliter. Principal Investigator: Dr Andrew containing regimens. Principal Strickland. Investigator: Dr Geraldine Goss. The ability of a uracil breath test and a thymine loading test to correctly identify A randomized, Phase 1b/2 trial of AMG Phase II trial of BNC105P as 2nd line patients who have experienced severe 5 102 OR AMG 479 in combination with chemotherapy for advanced malignant Fluorouracil (5FU) toxicity: A Pilot Study. panitumumab versus panitumumab pleural mesothelioma. Principal Principal Investigator: Dr Marion Harris. alone in subjects with wild-type KRAS Investigator: Dr Peter Briggs. metastatic colorectal cancer. Principal A Phase Ib/II study of CYT997 in Investigator: Dr Andrew Strickland. combination with carboplatin in PUBLICATIONS SUMMARY relapsed glioblastoma multiforme. A Phase 2 randomised double-blind Principal Investigator: Dr Jason Lickliter. placebo controlled study of AMG386 in Journal articles 7 combination with FOLFIRI in subjects A multicenter, open-label Phase 1b/2 with previously treated colorectal Books 1 study to assess the safety and clinical carcinoma. Principal Investigator: Conference presentations 2 activity of intravenous combretastatin Dr Andrew Strickland. A1 diphosphage (OXi4503) as monotherapy in subjects with primary or secondary hepatic tumour burden. Principal Investigator: Dr Jason Lickliter.
56 Southern Health Research Report 2010 57 RESEARCH GROUP REPORTS
Mental Health: Centre for Developmental Psychology and Psychiatry Child and Adolescent Mental Health Service
DIRECTOR: PROFESSOR LOUISE NEWMAN
The Monash University Centre for Developmental Psychiatry and Psychology (CDPP) was established in December 1989 as a conjoint clinical research Centre of Monash University Faculty of Medicine and Southern Health’s Monash Medical Centre Child and Adolescent Mental Health Service.
The CDPP has developed a substantial PROJECTS THE CENTRE WAS Funding: funding base to conduct research and associated teaching and clinical services PARTICULARLY PROUD OF Competitive IN 2010 WERE: in two major streams: NHMRC Project Grant. The effects of The psychopathology, neuropsychology Children’s Recovery Project; oxytocin nasal spray on mechanisms and treatment of developmental of social-communication in young School Refusal Project; disabilities (intellectual disability people with autism. Prof B Tonge, Prof S Einfeld, Dr K Gray, Prof T and autism); Treating Trauma in Refugee Youth. Lambert, Dr A Guastella, Dr N Rinehart. The phenomenology and treatment 2010: $92,700. of childhood emotional internalising
disorders (depression and anxiety). PUBLICATIONS, NHMRC. Comparison of psychotherapy POSTGRADUATE STUDENTS with and without medication for school AND FUNDING SUMMARY refusing youth with an anxiety disorder. The centre works in close affiliation with Prof B Tonge, A/Prof N King, A/Prof E the clinical services provided by the Journal articles 15 Gullone, Dr G Melvin. 2010: $171,875. Southern Region Child and Adolescent Mental Health Service (CAMHS) as well Books 1 NHMRC. Examining the brain basis of as CAMHS in Bendigo, Mildura, Barwon, social cognitive impairment in autism Wangaratta, and the LaTrobe Valley. Book chapters 1 spectrum disorders. Dr P Enticott, Close working affiliations also exist with P. Fitzgerald, B.Tonge, N.Rinehart, Conference presentations 49 the intellectual disability services in the J.Bradshaw. 2010: $69,750. Murray Murrumbidgee, Sutherland, Postgraduate research students 31 Wollongong and Grafton areas of NSW NHMRC. Eye movements in autism and and in South Australia. These links Asperger’s disorder. E/Prof J Bradshaw, provide a substantial base of patients Prof B Tonge, A/Prof O White, Dr N who form the focus of the range of Rinehart, Dr J Fielding. 2010: $63,875. clinical research projects. NHMRC Project Grant. A course of oxytocin nasal spray to improve social communication in young people with autism. Dr A. Guastella, Prof S. Einfeld, Dr K. Gray, Dr N. Rinehart. 2010: $104,500.
56 Southern Health Research Report 2010 57 RESEARCH GROUP REPORTS Mental Health: Centre for Developmental Psychology and Psychiatry
NHMRC Project Grant. Sex hormones NSW Health. Parenting with feeling: Department of Human Services. and social interaction. Dr W.C.Boon, Evaluation of an attachment focused A parent education and skills training Dr D. Stanic, Prof B. Tonge, Dr N. mentalization-based group intervention programme for adults with an ASD. Rinehart. 2010: $105,250. for substance abusing parents. Prof B Tonge, Dr A. Brereton. Prof. L.K. Newman, A. Dunlop. 2010: 2010: $186,956. NHMRC Training Fellowship. $49,263. An investigation of cortical function Department of Human Services. in autism spectrum disorders using Kinsman Research Fellowship. Evaluation of the Mansfield Autism TMS, fMRI and EEG. Dr P Enticott. Neurobiology of parenting disturbance Statewide Services Travelling Teacher 2010: $71,250. in postnatal depression. Prof L.K. Service. Dr A. Brereton, Ms K Bull. Newman. 2010: $55,000. 2010: $120,000. Dara Foundation. Establishment of the Research and Evaluation Function of ARC Linkage. The transition from National Alliance for Research the VAPP Glen Nevis Clinic (Revised). secondary school to adulthood: on Schizophrenia & Depression. B.Tonge, S. Dean, J. Beaufoy. experiences and life outcomes for youth Enhancing neurobehavioural and 2010:$53,531. with an intellectual disability and their clinical definitions in Autism Spectrum families. Dr HM Leonard, Dr C Bower, Disorders. J. Fielding, N. Rinehart. ARC Discovery Project Grant. Behaviour Prof N de Klerk, Prof GM Llewellyn, 2010: $56,000. and emotional problems in young Prof SL Einfeld, Prof TR Parmenter, children with developmental delay. Prof BJ Tonge, Dr V Riches, A/Prof NG Dr K Gray, Prof B Tonge, Prof S Einfeld. Lennox. 2010: $77,000. 2010:$110,000. Department of Human Services. NARSAD Young Investigator Award. Children First Policy: Autism Secondary Cortical inhibition and the mirror neuron Consultation and Training Strategy. system in autism spectrum disorders. Prof B Tonge, Dr A. Brereton. 2010: Dr P Enticott, Dr N Rinehart. 2010: $149,500. $14,125. Apex Foundation for Research into ID. Dara Foundation. Time for a Future: Ocular motor functioning in Williams Youth Psychotherapy and follow-up and Downs syndromes. N.Rinehart, project. Prof B Tonge, Ms J Pullen, B.Tonge, J. Bradshaw, J. Fielding. Dr S Gold, Ms J Beaufoy. 2010: 2009-2010: $16,151. $68,000. Beyond Blue. Treating trauma in Financial Markets Foundation for refugee youth: An Australian experience. Children. Teaching emotion recognition Dr Glenn Melvin, Prof Louise Newman, skills to young children with autism. Ann Locarnini, Meredith Levi. 2010: Dr K Gray, Prof B Tonge, Prof S Einfeld. $101,384. 2010: $43,804. NHMRC equipment grant. MRI and TMS ARC. Enhancing mental health in compatible electroencephalography Aboriginal children. Prof L.K. Newman, system (EEG) and an MRI compatible R.A. Bryant, D. Silove, R.Brooks, Z. transcranial magnetic stimulation Steel, K.Senior. 2010: $333,070. system (TMS). N. Georgiou-Karistianis, P. Fitzgerald, J. Stout, K. Cornish, J. ARC Linkage. Effectiveness of social Maller, S. Rossell, S. Miller, P. Enticott, skills training for children with autism. N. Rinehart, J. Bourne, K. Hourigan, R. Prof S Einfeld, Dr Katherine Sofronoff, Rajan, J. Hohwy, V. Dubaj, J. Zhang. Dr Kylie Gray, Dr Jacqueline Roberts, 2010: $237,000. Dr Renae Beaumont. 2010: $95,000. Beyond Blue. Building Children’s Australian Rotary Health. Efficacy of Resilience in Fire Affected Communities. N-acetylcysteine in autism: A double- Prof Graham Burrows, Dr Glenn blind, placebo-controlled randomised Melvin, Mr Alan Sutherland, trial. Prof M. Berk, Dr S. Dodd, Prof B. Ms Megan McQueenie, Prof B Tonge, Dr K. Gray, Dr A. Brereton. 2010: Tonge. 2010: $67,547. $38,500.
58 Southern Health Research Report 2010 59 RESEARCH GROUP REPORTS
Mental Health: Clinical Trials Research Group (Psychiatry)
CLINICAL DIRECTOR : ASSOCIATE PROFESSOR SAJI DAMODARAN
The focus of the Clinical Trials Research Group (Psychiatry) (CTRG) is to conduct research in the field of mental health.
The majority of this research involves At the end of 2010, two of the The CTRG provided a Positive and randomised clinical trials of mental health commercially sponsored drug trials Negative Syndrome Scale (PANSS) therapies that are conducted in conjunction were still being conducted. The training session to Southern Health with pharmaceutical companies looking at commercially sponsored drug trials that clinicians. This tool is useful in the psychopharmacology and biological completed in 2010 investigated residual measuring psychotic symptom changes basis of different psychiatric conditions apathy in individuals with depression, over a period of time. Many clinicians in developing new and more suitable investigated a new combination of that came to the training session may medication. As the CTRG has flourished medication for the treatment of individuals opt to use this tool in clinical practice to and its reputation increased, more health with treatment-resistant depression and help monitor and improve patient care. care professionals in the area have the final completed study investigated joined to facilitate their research interests a new formulation for schizophrenia Our reputation has continued to and to influence clinical practice within treatment. In addition, towards the end grow in 2010 resulting in a greater Southern Health. of 2010, the CTRG were sought out number of pharmaceutical companies and accepted as a site for seven new selecting the CTRG to conduct their commercially sponsored drug trials, which research trials. The increased demand for CTRG will commence in 2011. These projects experience and support has led to a have all been overseen by Associate wider range of study areas and resource Professor Saji Damodaran with the FUNDING SUMMARY development. The CTRG has now support of Dr Atanas Yonchev, Dr Marcelo conducted a number of studies and Rosenstein and Dr Danny Thomas. continues to seek out future research Funding: opportunities that cater for the diverse interests of its members. Commercial RESEARCH ACHIEVEMENTS Astra Zeneca IN 2010 RESEARCH ACTIVITIES Eli Lilly Successfully completed several trials from which we recruited many Janssen Cilag The CTRG had a busy 2010 with five participants, all of whom received
commercially sponsored drug trials, a outstanding care from the CTRG and Otsuka multi site trial in collaboration with the many of whom responded well to the Other Monash Alfred Psychiatry Research Centre, medication. These participants are a medication usage audit of the Southern continuing to remain stable on this new Southern Synergy Seeding Grant. Health psychiatry inpatient units, a study of medication and no longer requiring Inpatient Mood Stabilizer Audit Tool. mortality in patients who accessed mental Southern Health services. Rosenstein M. 2010: $5,000 health services in south east Melbourne (Southern Health). and the continued development of a mood stabiliser drug monitoring tool for use in the inpatient units (the latter is being run by Dr Marcelo Rosenstein who successfully received a grant from Southern Synergy).
58 Southern Health Research Report 2010 59 RESEARCH GROUP REPORTS REPORTS GROUP RESEARCH RESEARCHPsychiatry and GROUPPsychology REPORTSDevelopmental for Centre Health: Mental
Mental Health: Early in Life (infant to youth) Mental Health Service
DIRECTOR EARLY IN LIFE: MS LISA LYNCH
UNIT HEAD CHILD AND ADOLESCENT PROGRAM: DR MICHAEL GORDON
The Early in Life (EIL) Mental Health Service has a number of areas of research related to the Endeavour Clinic multidisciplinary assessment team, adolescent suicide assessment and evaluation of the intake and assessment of referrals into the service.
The main areas of research are: School-refusal clinic is a collaborative Feedback reports from these pilot research between EIL and the Centre for programs conducted in 2010 indicated The CAMHS and Schools Early Developmental Psychiatry & Psychology 96% level of parental satisfaction with Action (CASEA) program is an early treating youth 11 to 16 years who are the ET program, 93% improvement in intervention program with children suffering with anxiety and depression parent relationship with child and 88% (Grades prep-3) with behavioural/ and are unable to attend school. of parents indicated changes in their emotional problems. The CASEA School-refusal clinic is a randomised child’s behaviour. program is utilising a comprehensive control trial which is investigating the educational group program, Exploring treatment of school refusing young In 2010 EIL has with Professor Bruce Together Early Primary School Program people who experience anxiety and/or Tonge and the Centre for Developmental (ET) involving the parents and children depression using both psychological Psychiatry & Psychology published within the Southern Health catchment. and pharmacological treatment six month follow-up data on a cohort approaches. of 130 adolescents who were referred The Southern Health Butterfly for treatment of clinical depression. A Eating Disorders Day Program three to nine year follow-up of this same provides intensive treatment for up RESEARCH ACHIEVEMENTS cohort has been completed and the to 12 individuals aged 12 to 24 years predictors of outcome of this original diagnosed with an eating disorder. An IN 2010 sample is pending publication. experienced multidisciplinary team The CASEA program has completed provides individual, group and family The school refusal has assessed 53 three 7-week pilot programs in the therapy with a focus on nutritional young people who were diagnosed Cardinia Casey (Hampton Park rehabilitation; normalisation of eating with an anxiety disorder. These young Primary) and Dandenong (Wallarano behaviour; correcting dysfunctional people were randomly assigned to Primary & Wooroona Park Primary) attitudes towards eating and weight; treatment. The majority of this group local government areas. The official body image issues and relapse has been treated and completed 12 evaluation of the ET program will begin prevention. Two research projects are month follow-up. in Term 2 2011. In the pilot CASEA currently being undertaken to assess program 7.5 hours of professional the effectiveness of day program development were given to three treatment in eating disorders; one to be schools, accessing 90 staff and completed in May 2011 and the second covering topics: Introduction to currently undertaking data collection. CASEA, Introduction to the Strengths and Difficulties Questionnaire and Understanding Challenging Behaviour/ Positive Behaviour change.
60 Southern Health Research Report 2010 61 RESEARCH GROUP REPORTS Mental Health: Early in Life (infant to youth) Mental Health Service
RESEARCH ACTIVITIES The Butterfly Eating Disorders Day Program is a joint, self-funded project The Child and Adolescent Mental between Monash CAMHS and the Health Service (CAMHS) and Schools Centre for Developmental Psychiatry & Early Action (CASEA) program is an Psychology. The program is designed early intervention program that aims to to evaluate and treat young people improve community access to mental (12-24 years) with an eating disorder health professionals during early using a multi-disciplinary approach in childhood, to strengthen community a day-program setting. Since 2007 the understanding of challenging program has treated 50 young people. behaviours, to increase the skill level A standardised assessment battery of schools in the management of is administered pre-treatment, at two challenging behaviours, and ultimately, monthly reviews and at discharge to ensure young people experiencing enabling an evaluation of treatment behavioural and emotional problems outcome. The CDPP has brought to receive the support they need during this collaborative project expertise in this critical developmental period. Early evaluation of clinical programs, data in Life – Perinatal to Youth Service are management, and analysis. utilising a comprehensive educational group program, Exploring Together This project has also involved an Early Primary School Program (ET), honours psychology student who with parents and children (Grades has worked under the supervision of prep-3) with behavioural/emotional Professor Newman and Dr Melvin. problems. These children are attending The project is underway and is government and Catholic primary expected to be completed in 2011. schools within the Southern Health catchment. PUBLICATIONS AND Early in Life are conducting an FUNDING SUMMARY evaluation of this program over the next three years. The aims of the Journal articles 4 ET program is that children with behavioural and/or emotional problems Book chapters 2 and their parents will experience Conference presentations 15 improved child problematic behaviour, enhanced child social skills and self-esteem, and exposure to a range Funding: of parenting techniques aimed at assisting children develop better ways Other of managing their feelings. School staff Southern Health Mental Health also receive a series of professional Research Seeding Grants. An development sessions designed to Attachment-Based Group Parenting provide developmental and mental Intervention for Depressed Mothers. health information and strategies. Prof. L. Newman, Dr. G. Melvin, Dr. D. Eyles & Ms L Cotton. 2010: The evaluation of the program includes $5,000 (Southern Health). pre assessment, post assessment (on conclusion of the nine week program), and two long term follow up assessments at six and twelve months. As such, this evaluation will determine any short term and longer term gains made in the management of difficult behaviours, improvement in child self-esteem and social skills and change in parenting practices.
60 Southern Health Research Report 2010 61 RESEARCH GROUP REPORTS
Mental Health: Psychological and Behavioural Medicine
CLINICAL DIRECTOR: PROFESSOR DAVID CLARKE
The Psychological and Behavioural Medicine Unit seeks to foster improved health in individuals and the community, informed psychological care of the physically ill, and an integrated system of behavioural and physical health care.
Its research has focussed on the nature Current projects Development of a quality-of-life measure and treatment of depression occurring for facioscapulohumeral dystrophy
in the medically ill and integrated forms Heart Failure Manual CDSM project. (FSHD). Investigators: Triecia Gibney, of chronic disease self-management, Investigators: David Clarke, Donita David Clarke. Ethics application particularly in cancer, heart disease and Baird. Manual written; pilot study completed; study in early stages. diabetes in which co-morbidity is common. completed; presented at conferences; being used in a number of clinical sites. Prevalence and correlates of The “Whole Person Model” has been hypochondriasis in the Australian RESEARCH ACHIEVEMENTS developed for individuals with chronic population (analysis of NSMHWB). conditions and complex psychosocial Investigators: David Clarke, Graham IN 2010 needs at high risk of hospital admission Meadows. Analysis completed; Completion of an integrated disease with funding from Department of Health presented at conferences; paper self management program for heart and Ageing. under preparation. failure that is being used in many heart The Melbourne Depression in Heart Application of tailored psychosocial failure clinics around Australia. Failure Collaborative Medication Trial therapies to reduce distress and Publication and dissemination of a – Proheart. Investigators: David Hare depression in cancer patients: a guide to the management of depression (Austin), David Clarke, Henry Krum, randomised trial. Investigators: in primary care, featuring a novel but Bruce Jackson. Recruitment and data Jane Turner (Brisbane), Brian Kelly useful taxonomy of depression. collection occurring. (Newcastle), David Clarke (Monash). Ethics approved; recruitment beginning.
International collaborations A comparison of psychosocial examining cross-cultural aspects to issues across four cancer groups. A cross-national multi-center study the phenomena of depression and Investigators: David Clarke, Claire Wise. of depression, demoralization and demoralisation, funded by the World Data collection complete, statistical functional impairment in cancer Psychiatric Association. analysis and report writing occurring. patients. Investigators: John de Figueiredo (US), Giovanni Fava
Healthy Mind, Healthy Heart: (Bologna), David Clarke (Monash). Assessment of depression and Ethics approved; recruitment beginning. related psychological factors in CALD people with CHD. Investigators: Litza Application of integrated disease Kiropoulos, Ian Meredith, Andrew self-management in type 2 diabetes Tonkin, David Clarke, Leon Piterman. mellitus. Investigators: David Clarke, Data collection very nearly completed. Donita Baird, Virginia Hagger, Helena Teede. Early stages of material development and focus groups.
62 Southern Health Research Report 2010 63 RESEARCH GROUP REPORTS Mental Health: Psychological and Behavioural Medicine
PUBLICATIONS, POSTGRADUATE STUDENTS AND FUNDING SUMMARY
Journal articles 3
Book chapters 1
Conference presentations 8
Postgraduate research students 4
Funding:
Competitive • Department of Health and Ageing, Project Grant. Development of the ‘Whole Person Model’ approach to self management for individuals with chronic conditions and complex psychosocial needs at high risk of hospital admission. D Baird, DM Clarke. 2010: $65.000. 2009-2010: $130,000 (Monash University).
Department of Veteran Affairs, Project Grant. Sequelae of psychiatric conditions and multisymptom disorder after stressful events: Gulf War veteran cohort follow-up. MR Sim, S McFarlane, AB Forbes, H Kelsall, DM Clarke, DP McKenzie. 2010: $198,000. 2010-2013: $595,000 (Monash University).
beyondblue the national depression initiative, Project Grant. Application of tailored psychosocial therapies to reduce distress and depression in cancer patients: a randomised trial. J Turner, B Kelly, DM Clarke, P Yates, S Aranda, D Jolley. 2010: $198,000. 2010-2013: $594,000 (Monash University).
Bupa foundation, Project Grant. Application of integrated disease self-management in type 2 diabetes mellitus. DM Clarke, D Baird, V Hagger, H Teede. 2010: 137,000. 2010-2012: $436,000 (Monash University).
World Psychiatric Association, Project Grant. A cross-national multi-center study of depression, demoralization and functional impairment in cancer patients. JM de Figueiredo, G Fava, DM Clarke. 2010: 25,000. 2010-2012: $50,000 (Monash University).
62 Southern Health Research Report 2010 63 RESEARCH GROUP REPORTS
Mental Health: Southern Synergy Southern Health Adult Psychiatry Research, Training and Evaluation Centre
DIRECTOR: PROFESSOR GRAHAM MEADOWS
Southern Synergy, which is the shorter name for the Southern Health Adult Psychiatry Research, Training and Evaluation Centre is part of the School of Psychology and Psychiatry at Monash University and is a Faculty Research Centre within the Faculty of Medicine, Nursing and Health Sciences.
It was jointly established in 2003 with RESEARCH ACHIEVEMENTS RESEARCH ACTIVITIES Southern Health and continues to be closely linked with and supported by IN 2010 the Southern Health Mental Health The team in the mindfulness Workforce program research: Program. The centre is presently based program has successfully taken Staff, Stress Management, on the Notting Hill Campus and exists forward the challenge of the largest Risk Management and to champion research, knowledge and ever randomised controlled trial of Occupational Mindfulness understanding in mental health care. mindfulness –based cognitive therapy Research The centre is dedicated to activities aimed (MBCT) over 4 years. As 2010 has at both teaching/education and research/ unfolded it has become clear that Investigators John Julian, Joanne evaluation and this work is grouped retention rates will be very strong Brooker, Graham Meadows. Stress into a series of programs including: a through the study, meaning that it impacts personal leave usage and staff directorate; Early Intervention; Headache will have every potential to be a very retention in mental health services. Stress and Migraine; Health Services Research; important resource for understanding Management Education and Occupational Mindfulness; Rehabilitation and Nutrition; the effectiveness of this novel Mindfulness (OM) training programs and Workforce. Each is headed by a senior therapeutic approach. Preliminary have been developed at South East academic with Monash University who also analyses are now under way and Education and Training Cluster (SEETC) has a Southern Health appointment. indicate an overall positive effect for with Southern Synergy, initially for work the MBCT intervention. Reporting will in the Intellectual Disability sector but be a major task for 2011. now extending into other settings. OM, a behaviour change course consisting of Publication of significant cross- 8x2 hour sessions, involves mindfulness national research involving Australia processes and principles. Each session and the Netherlands. is carefully adapted from the evidence- based Mindfulness-based Cognitive
The Headache Program has taken Therapy program. A wait-list control group forward two major studies in the design will be used with the program run areas of triggers and psychiatric in different hospitals, including Southern comorbidity. Similarly the data now Health, Latrobe Regional Health and is accumulating that will enable a Peninsula Health. SEETC funds have substantial research output to flow been provided for ethics applications from the work of this group. and some training.
64 Southern Health Research Report 2010 65 RESEARCH GROUP REPORTS Mental Health: Southern Synergy
Mindfulness Program: Collaborative work with a team from the Early Intervention The DARE (Depression Netherlands found that in both countries, Professor Murphy has led the development Awareness Recovery the vast majority of mental health care needs are not fulfilled with substantial of a research program to investigate Effectiveness) project commonalities of consumer experience negative symptoms, medical comorbidity, Investigators Graham Meadows, Fiona across these two very different countries. genetic epidemiology, service models and Judd, Paul Martin, Zindel Segal, Leon A successful grant proposal to beyondblue delivery, and neurocognitive markers of Piterman: This study is examining if supports work looking at labour market violence in schizophrenia. Collaborators MBCT when added to existing treatment costs of mental illness. (Investigators Brett include Orygen Youth Health, Forensicare, as usual plus supported self-monitoring Inder, Graham Meadows). A new strand the Australian Schizophrenia Research (DRAM: Depressive Relapse Active of work involves simulation modelling Bank and the Alfred Psychiatry Research Monitoring) is more effective than approaches to support planning in mental Centre. Clinically, Associate Professor DRAM in preventing depressive relapse health services; this broad collaboration Murphy has developed an early psychosis in people who have had at least three with health economics and information clinical pathway to ensure best practice, prior episodes of depression. Monthly technology and also with Southern Health including the early detection and data collection continued during 2010 management is gathering pace with an management of medical comorbidities, and we also commenced data analysis. award at the end of the year of a faculty and a risk factor questionnaire for Preliminary findings indicate that people grant from Monash University to support prognosis in schizophrenia. He is who completed a “dose” of MBCT pilot work. spearheading the youth service component (≥ 4 sessions) were less likely to relapse of Australia’s first mental health service for people aged 0 to 25 years, currently compared to control in the first year of The Conquer Headache follow up. An honours student (psychology) in development at Southern Health. obtained a high distinction for her thesis Program Key projects are: examining recall bias. The Conquer Headaches Program is based on a functional model of headaches Aggression and Facial Affect Health Services Research published by Paul Martin which seeks to Recognition Deficits in First-episode explain the variance in headaches, by Psychosis: ongoing (recruitment program asking questions such as: Why does a completed n=75 in Feb 2011); The first part of a contract with the headache occur at one time rather than
Department of Health, Victoria to analyse another? Why are headaches occurring Problem-solving based bibliotherapy for data from the National Surveys of Mental at this time in a person’s life rather than primary caregivers of family members Health and Wellbeing 1997 and 2007 and at other times? Why did the headaches with first-episode psychosis: A from the National Health survey 2008 was begin when they did? Why is this person randomised controlled trial: recruitment completed and two reports were submitted vulnerable to suffering from headaches? completed; Active projects through 2010 have to the Department of Health. This work A 12-week, parallel, double-blind, been the Headaches and Depression - investigated the prevalence of mental randomised, placebo-controlled Overcome Now (HeaD-On) project funded disorders, their impact on disability and adjunctive study of taurine 4 grams by beyondblue (investigators Paul Martin, days lost, and the use of mental health in 128 patients with first-episode Graham Meadows, David Reutens, Leon services in Victoria and Australia. The psychosis receiving antipsychotic Piterman. Martin Sharman, Liain Nejad) findings of this work make an important treatment: recruitment completed; contribution to a better understanding and the Headache and Migraine Program of mental health issues and services in Mastery of Triggers to Conquer Headaches Incidence and prevalence of insulin Victoria and nationally and to informing (MaTCH) project funded by the NHMRC resistance, metabolic syndrome future policy in Victoria. The third and (investigators Paul Martin, Peter Goadsby). and cardiovascular risk factors in final report, investigating the meeting of young adults with psychosis (GEMS): need and barriers to mental health care recruitment completed n=99; in Victoria and Australia is currently under way. (Investigators Graham Meadows, The Negative Symptom Onset Scale Irene Bobevski, Brett Inder, Scott Patten, – a new tool to assist the research Paul Martin). and clinical management of negative symptoms: reliability and validity: pilot study completed n=12;
A multisite study on mania with recruitment ongoing.
64 Southern Health Research Report 2010 65 RESEARCH GROUP REPORTS Mental Health: Southern Synergy
PUBLICATIONS AND FUNDING SUMMARY
Journal articles 9
Conference presentations 3
Funding:
Competitive NHMRC, Project grant. Should all triggers of headaches be avoided, or should headache sufferers learn to cope with some triggers? Martin, P.R., & Goadsby, P.J. 2010: $208,500. 2009-2011: $486,000 (Monash University).
NHMRC, Project grant. Depression, Awareness, Recovery, Effectiveness (DARE). Meadows, G, Martin P, Pitterman L, Segel Z, Judd F. 2010: $133,275. 2007–2010: $611,775 (Monash University).
Beyond Blue, Project grant. Labour Market costs of Mental Illness. Inder B, Meadows G. 2010: $15,000. 2010–2011: $50,000 (Monash University).
Victorian Office of Senior Practitioner, Contract research. Office of Senior Practitioner Training – Occupational Mindfulness. Meadows G, Julian J, Brooker J. 2010: $50,000. 2009–2011: $102,880 (Monash University).
Department of Mental Health Branch, Contract research. National Survey of Mental Health & Wellbeing research. Meadows G, Bobesvski I, Inder B, Martin P. 2010: $20,000. 2010–2011: $99,000 (Monash University).
Heart Foundation, Project grant. Genetic epidemiology and metabolism study. Foley D, Murphy B. $65,500. 2009-2011: $130,000 (Orygen Youth Health).
Commercial OM and inpatient units from cluster. OM and inpatient units from cluster, workforce cluster project grant. Julie J & Meadows G. 2010: $11,000 (Monash University).
66 Southern Health Research Report 2010 67 RESEARCH GROUP REPORTS
Monash Children’s
DIRECTOR: PROFESSOR NICK FREEZER
The Children’s Cancer Centre The Paediatric Endocrinology Paediatric Endocrinology and Diabetes Department and Diabetes The current research focus at the Children’s Cancer Centre is based on The department has a major focus on Completed a longitudinal study of enrolment in clinical trials. From a clinical collaborative diabetes research. We screening for celiac disease in Type 1 treatment perspective this has meant the established a diabetes database within Diabetes Mellitus of those individuals on development of a clinical trials program the National Diabetes Database under our Monash database over the last 20 that aims to ensure the best practice the auspices of the Australasian Paediatric years and are currently preparing this treatment protocols are available to Endocrine Group (APEG) over 15 years work for publication. families. The clinical trials program at the ago and this has enabled us to participate centre is expanding with the increased in larger national and international Paediatric Respiratory patient numbers and complexity of epidemiological diabetes studies. Our treatment protocols over the last few years. department also has a specific clinical Ms Rebekah Beard successfully completed focus of psychological support and we her BMedSc honours project “Living with Currently has nine clinical trials actively aim to develop increasing research Cystic Fibrosis”. This project received open for the treatment, data collection expertise in this area, by establishing funding from both Cystic Fibrosis Victoria and Cystic Fibrosis Australia. Dr Marc and study of childhood cancers. “Life research links with Monash University’s Theilhaber completed his RACP advanced threatening cancer across the lifespan: School of Psychology and Psychiatry. Examining the relevance of music to training project “Post-tonsillectomy children (0-14 years)” was a multi-site complications in children aged less than project conducted at Southern Health, RESEARCH ACTIVITIES two years with severe obstructive sleep Royal Children’s Hospital and Peter apnoea admitted to the Monash Medical Centre Intensive Care Unit.” MaCallum Cancer Centre. Study Melbourne Children’s outcomes indicated that children’s Sleep Centre adverse cancer experiences are often Fetal Cardiac Unit alleviated by music usages. 24th Annual Meeting of the Associated Ms Jennifer Re has completed her PhD Professional Sleep Societies – awarded thesis breaking new ground and reviewing the Winner of the 2010 Childhood Sleep The Melbourne Children’s the impact of prenatal and postnatal Disorders and Development Section Sleep Centre diagnosis of complex congenital heart Investigator Award: “Discrepancy between disease on the mother-infant relationship. The centre is currently completing a 3-year Cognitive and Behavioural Profiles of study funded by the NHMRC evaluating Young Children with Sleep-Disordered the cardiovascular and neurocognitive Breathing”. Jackman A, Davey M, Nixon Paediatric Infectious Diseases consequences of obstructive sleep apnoea G, Hope S, Catroppa C, O’Driscoll D, First description of association between (OSA) on pre-school children. This study Anderson V, Trinder J, Horne R. new generation rotavirus vaccines will help us understand more about the In conjunction with the Ritchie Centre, and intussusceptions presented and degree of OSA that is associated with Monash Institute of Medical Research, the published resulting in changes to cognitive or behavioural impairment in this Melbourne Children’s Sleep Centre was product information and WHO guidance. young group of children, which is likely successful in obtaining two new project Co-leading International Kawasaki Disease to impact on treatment decisions in the grants totalling $847,288 from the NHMRC Genetics Consortium which completed its clinical area. to commence in 2011. We expect both of 2nd genome wide association study of KD, these projects to produce results that will involving over 3000 participants. have important translational benefits to patient care, especially in relation to the Paediatric Surgery diagnosis and treatment of obstructive Professor Wei Cheng was conferred sleep apnoea. Visiting Professor by the Chong Qing Medical College, China.
66 Southern Health Research Report 2010 67 RESEARCH GROUP REPORTS Monash Children’s
PUBLICATIONS, NIH, R03 Grant. The role of APOE Other in Cerebral Palsy. Boyd R, Wallace Western Australian Institute for POSTGRADUATE STUDENTS R, Blackman J, Fahey M, Sinclair K, Medical Research. ACDDR (Australian AND FUNDING SUMMARY Rose S. 2010: US$21,000. 2008-2010: Childhood Diabetes DNA Repository). US$63,000 (University of Virginia). Journal articles 66 Rodda C. 2010: $12,200 (Monash NHMRC. Cystic Fibrosis. Bell S, Bye P, Children’s). Conference presentations 78 Rose B, Harbour C, Mark G, Robinson Melbourne Health. TrialNet (Natural P. 2010: $77,177. 2007-2009: Carry Postgraduate research students 5 History Study of the Development of over funds (Monash University). Type 1 Diabetes). Bergman P. 2010: Funding: MCRI, Top Up Grant. Oakley E. $1,500 (Monash Children’s). 2010: $30,000. Competitive APEG (Australian Paediatric Endocrine Group). National Diabetes Registers NHMRC, Project Grant. Impact of Commercial trials in collaboration with the Children’s Oncology Group (The Epidemiology of Diabetes in Sleep Disordered Breathing on children and adolescents in Australia). Cardiovscular, Behavioural and Classification of Acute Lymphoblastic Rodda C. 2010: $15,000 (Monash Neurocognitive Function in Pre-school Leukaemia Children’s). Children. Horne RH, Nixon GM, Davey MJ, O”Driscoll DM, Trinder J, Anderson Standard Risk B-prescursor Acute V. 2010: $136,000. 2008-2010: Lymphoblastic Leukemia $408,000 Monash University High Risk B-precursor Acute (Ritchie Centre, MIMR). Lymphoblastic Leukemia Helen McPherson Smith Grant. Biology Study of Transient Bladder exstrophy work. Cheng W. Myeloproliferative Disorder (TMD) in 2010: $25,000. children with Down Syndrome (DS) Jack Brockhoff Grant. Bladder A Phase II Study of IMC-A12 (Anti-IGF-I genetics. Cheng W. 2010: $40,000. Receptor Monoclonal Antibody NHMRC. Protecting asplenic children. Treatment of High Risk Renal Tumours Buttery J, Barnes C, Monagle P, Lindeman R, Spelman D. 2010: Renal Tumours Classification, Biology $150,000. 2009-11: $455,000 (MCRI). and Banking Study
NHMRC, Project Grant. Comparative Vincristine, Dactinomycin and Lower rehydration in bronchiolitis. Oakley E. Doses of Cyclophosphamide with 2010: $250,000 of $851,514. or without radiation therapy for patients with newly diagnosed low NHMRC, Postgraduate scholarship. risk embryonal/Botryoid/Spindle Cell The heart of the matter: the developing Rhabdomyosarcoma mother-infant relationship in prenatal and postnatal diagnosis of congenital Risk-based treatment for non- heart disease. Re J. 2010: $220,000. rhabdomyosarcoma Soft Tissue 2008-2010: $650,000 (SH, PHI, MIMR, Sarcomas in Patients under 30 years MU, MCRI). of age
Kathleen Tinsley Trust. Wong F. $60,000 Soft Tissue Sarcoma Diagnosis, (Monash University). Biology and Banking Protocol
NHMRC, Project Grant. Prospective A Phase II trial of conformal radiation cohort study of children with cerebral therapy for pediatric patients with palsy. Boyd R, Rawicki B, Fahey M, localized ependymoma, chemotherapy Krageloh-Mann I. 2010: $155,000. prior to second surgery for incompletely 2007-2010: $464,525 resected ependymoma (Monash University).
68 Southern Health Research Report 2010 69 RESEARCH GROUP REPORTS REPORTS GROUP RESEARCH RESEARCH GROUP REPORTS Children’s Monash
Monash Newborn
DIRECTOR: DR ANDREW RAMSDEN
Monash Newborn provides Victoria’s largest tertiary neonatal service and has a longstanding and close association with the Ritchie Centre in the Monash Institute of Medical Research.
Bringing together the clinical expertise Most recently, this program of Dr Arvind Sehgal’s research over of neonatal specialists and the scientific development of cPMP as treatment for the year 2010 has focussed on expertise of the Ritchie Centre staff, Molybdenum Cofactor Deficiency was cardiovascular function in sick unrivalled opportunities exist to undertake successfully negotiated with acquisition preterm infants using point of care translational research on topics of key by a major US orphan drug company. clinician performed echocardiography, relevance to the care of infants born Alexion Pharmaceuticals in the US have particularly after administration of preterm or critically unwell. purchased the patents and assets of indomethacin for medical closure of the MoCD/cPMP program on February the patent ductus arteriosus (PDA), 10, 2011 for USD $11 million. and after its surgical ligation. A key RESEARCH HIGHLIGHTS collaborator in this work has been IN 2010 Organisation of the 2nd Symposium Dr. Patrick J. McNamara (Assoc. Prof, on Functional Echocardiography and Neonatologist and Director of Clinical The Monash Newborn clinical team Neonatal Haemodynamics at Monash Research at The Hospital for Sick developed a novel treatment known as Medical Centre in October 2010 Children, Toronto, ON, Canada). This cPMP for a metabolic disease known (chaired and organised by Dr Arvind work has demonstrated for the first time as Molybdenum Cofactor Deficiency Sehgal). Attended by 120 delegates that indomethacin causes a temporary and the world’s first baby with this from Australia and overseas and reduction in coronary perfusion, a lethal disease was successfully treated featuring national and international finding of potentially high importance at Monash Newborn. In recognition of speakers. since ECG changes suggestive of this work the team was awarded the myocardial ischaemia have already Dr Marcel Nold was awarded an Victorian Public Health Care Award been demonstrated in infants with PDA. NHMRC Project Grant for years 2010: Minister’s Award for Outstanding It has also contributed to a greater 2011-13; also the Larkins Fellowship, Team Achievement. To further progress understanding of the etiopathogenesis Monash University; and had a major this therapy an international clinical trial of cardiorespiratory deterioration which publication in Nature Immunology. “Safety and efficacy of cPMP in the occurs in about 30% of infants after treatment of patients with Molybdenum Dr Flora Wong was awarded an PDA ligation. Cofactor deficiency Type A. An NHMRC Project Grant for years 2011- He was also invited to conduct a international Phase II study” has been 13; was granted research funding of breakfast session at the 14th Annual established with Monash Newborn’s more than £120,000 from philanthropic Meeting of the Perinatal Society of Associate Professor Alex Veldman as organisations; was invited to give a Australia and New Zealand, Wellington, the principal investigator. plenary lecture to be presented to New Zealand; and presented three the Perinatal Society of Australia and original research papers at the 14th New Zealand in 2011; and received an Annual Meeting of the Perinatal Society international invitation to speak at the of Australia and New Zealand 2010 and IpoKrates Seminars in Jarkarta (Feb the 2010 Pediatric Academic Societies 2011) and Kuala Lumpur (Sept 2011). Annual Meeting, Vancouver, Canada and had 15 publications in international peer reviewed journals.
68 Southern Health Research Report 2010 69 RESEARCH GROUP REPORTS Monash Newborn
PUBLICATIONS AND Other FUNDING SUMMARY NHMRC. Which Oxygen Saturation level should we use for very premature Journal articles 30 infants? A RCT of Benefits of Oxygen Saturation Targeting Trial II (BOOST Conference presentations 14 II). W. Tarnow-Mordi. 2010: $10,000 (Southern Health). Funding: NHMRC. Neonatal Probiotic Study: Competitive The use of probiotics to reduce the incidence of sepsis in Premature Foundation for Children, Project Grant. Infants. S. Garland, Site Investigator Oxygen Delivery for the preterm infant A. Veldman. 2010: $11,000 – optimising delivery. Tan K, Ramsden (Southern Health). A, Berger P. 2010: $55,800. 2010-2012: $81,800 (MIMR). Kathleen Tinsley Fellowship. Novel approaches to bedside Phosphagenics Ltd, Research Grant. monitoring of cerebral oxygenation Use of Dopamine to Improve Brain in infants with HIE undergoing Oxygenation in Preterm Babies. therapeutic hypothermia. F. Wong. Flora Wong. 2010: $30,000. (MIMR). 2010: $50,000 (Dept of Paediatrics, Foundation for the Study of Infant Monash University). Deaths, Research Grant. Mechanisms for the protective effects of dummies. Horne RSC, Wong FY, Yiallourou SR. 2010: £85,790 (MIMR).
Scottish Cotdeath Trust 2010-2011, Research Grant. A mechanism for the increased risk of the Sudden Infant Death Syndrome in infants sleeping in the prone position. Horne RSC, Wong FY, Yiallourou SR. 2010: £36,000. 2010-2011: £36,000 (MIMR).
NHMRC Project Grant. Preventing preterm lung disease - a cell therapy approach. 2010-2012: $444,189 (MIMR).
Jack Brockhoff Foundation, Research grant. Anti-inflammatory therapy in preterm infants with Broncho-pulmonary dysplasia. 2010: $40,000 (MIMR).
70 Southern Health Research Report 2010 71 RESEARCH GROUP REPORTS
Melbourne Children’s Sleep Centre
DIRECTOR: DR MARGOT DAVEY
The Melbourne Children’s Sleep Centre is the only paediatric sleep lab in Melbourne, serving the populations of Victoria and Tasmania.
The centre carries out original clinical The centre is also taking part in an PUBLICATIONS, AWARDS, research and also collaborates with international study of ex-premature infants, The Ritchie Centre of the Monash Institute funded by the National Institutes of Health POSTGRADUATE STUDENTS of Medical Research. The clinical lab in the USA. This study aims to evaluate AND FUNDING SUMMARY performs approximately 1000 clinical the long term effects of caffeine treatment Journal articles 7 sleep studies each year and also has a in neonates on breathing control in research bed in the lab for studies carried school-age children. The researchers Conference presentations 8 out by The Ritchie Centre. The research are carrying out sleep studies in the focus is predominantly the neurocognitive homes of children, work that will also Awards 2 and cardiovascular consequences of extend the researchers experience with obstructive sleep apnoea in children, but home testing for sleep disorders. Postgraduate research students 1 the centre also performs research in all At Sleep 2010, the 24th Annual Meeting aspects of sleep disorders in children. Funding: of the Associated Professional Sleep Societies in Texas, an abstract from Competitive RESEARCH ACTIVITIES the centre was awarded Winner of the 2010 Childhood Sleep Disorders and NHMRC, Project Grant. Impact of The centre is completing a 3-year study Development Section Investigator Award: sleep disordered breathing on funded by the National Health and “Discrepancy between Cognitive and cardiovascular, behavioural and Medical Research Council evaluating Behavioral Profiles of Young Children with neurocognitive function in pre-school the cardiovascular and neurocognitive Sleep-Disordered Breathing.” Jackman A, children. Horne RH, Nixon GM, Davey consequences of obstructive sleep apnoea Davey M, Nixon G, Hope S, Catroppa C, MJ, O’Driscoll DM, Trinder J, Anderson (OSA) on pre-school children. This study O’Driscoll D, Anderson V, Trinder J, V. 2010: $136,000. 2008-2010: $408,000 will help with understanding more about Horne R. (Monash University (Ritchie Centre for the degree of OSA that is associated with Baby Health Research, Monash Institute cognitive or behavioural impairment in this In Southern Health Research Week 2010, of Medical Research)). young group of children, which is likely the poster “Clinical Utility of Oximetry as a to impact on treatment decisions in the First Test in a Paediatric Sleep Laboratory” clinical arena. (Yorkston SM, Davey MJ, Nixon GM) won the second poster prize.
70 Southern Health Research Report 2010 71 RESEARCH GROUP REPORTS
Nephrology
DIRECTOR: PROFESSOR PETER KERR
The Department of Nephrology conducts laboratory and clinical research in many areas pertinent to nephrology. These include laboratory research in mechanisms of immune injury in glomerulonephritis, diabetic nephropathy and transplant rejection.
Clinical research includes haemodialysis, reperfusion. The laboratory has models This includes investigation of peritoneal dialysis, mineral metabolism, of all of these conditions, in mice vascular calcification in this group, progression of chronic kidney disease and/or rats and is able to manipulate which is a major cause of morbidity and anaemia. these conditions in various ways in and mortality in dialysis patients. order to study the immunological and Dialysis patients appear to have The focus of laboratory-based research inflammatory mechanisms at play. a particular form of blood vessel within the department is to understand calcification, related to renal failure inflammatory mechanisms of renal injury in The laboratory has always had a specific factors, such as phosphate different types of kidney disease, including focus on the role of the macrophage retention. Examining the interplay of glomerulonephritis, diabetic nephropathy, in these mechanisms and has played phosphate control, parathyroid hormone renal transplant rejection and acute renal a key part in unravelling the role levels, vitamin D status and bone failure. This involves analysis of animal of the macrophage, especially in disease is of paramount importance models of kidney disease, cell culture glomerulonephritis. More recently, in unravelling this. Several projects studies, and examination of investigations in the laboratory by are underway in this area. Nutrition in patient samples. Dr Greg Tesch have clearly indicated dialysis patients has been another focus a role for immune mechanisms and with Dr Rebecca Pellicano’s thesis There is an emphasis on developing inflammation in the development of in this area completed in 2010. She new therapeutic strategies to prevent or diabetic nephropathy, a condition demonstrated that the unusual paradox halt renal injury using a range of different previously considered to be purely in renal patients wherein obese patients strategies, including pharmacologic related to the chemical and biochemical survive better than thinner patients drugs, protein-based molecules and effects of the elevated serum and related to preservation of lean body cell-based treatments. Clinical tissue glucose. mass (muscle). nephrologists are closely involved in the laboratory-based research, including The laboratory continues to attract Other areas of research include acting as co-supervisors for PhD students PhD students in nephrology, with four vascular access in dialysis patients, pursuing laboratory research. students in the lab in 2010 (and another with Associate Professor Kevan two participating in clinical research). Polkinghorne heading up an Australia- The department has continued their wide project to overcome the barriers RESEARCH ACTIVITIES successful run at national meetings to establishment of permanent access with two major awards at the Australian (as arterio-venous fistulae) in patients The laboratory research in the and New Zealand Society of Nephrology heading to dialysis. This has resulted department, under the direction of annual scientific meeting, including in an improvement in the number of Dr David Nikolic-Paterson, centres Dr Frank Ma winning the Amgen patients commencing dialysis with a on mechanisms of inflammation Science Award for the best scientific fistula – an important outcome as this and fibrosis in renal diseases. More presentation from an established is associated with improved long-term specifically this includes various forms researcher. outcomes in the patients. Several of glomerulonephritis as well as diabetic other projects involve kidney transplant nephropathy – between them the cause The clinical research efforts outcomes, with a concentration on the of 70% or more of all kidney failure; predominantly concentrate on difficult transplant – those with high but also includes transplant rejection, various aspects of nephrology related antibody titres or those who are ureteric obstruction and ischaemia- specifically to dialysis patients. ABO-incompatible with their donor.
72 Southern Health Research Report 2010 73 RESEARCH GROUP REPORTS Nephrology
RESEARCH ACHIEVEMENTS Monash University Strategic Grant, NHMRC, Project Grant. Resolvin Project support. Stem cell therapies for E1 is a novel anti-inflammatory and Dr Frank Ma won the Amgen Science patients with genetic kidney disease. anti-fibrotic lipid mediator for the Award at the Annual Meeting of the SD Ricardo, B Song, J Deane, A Laslett, treatment of chronic kidney disease. Australian and New Zealand Society of PG Kerr. 2011: $55,000 (Monash Li J, Nikolic-Paterson DJ. 2010: Nephrology in Perth. University). $166,417. 2010-2012: $499,251 (Monash University). Dr Shaun Summers won the Young Jacquot Foundation, Research Investigator Award at the Annual Meeting Entry Scholarship. Cell type specific Diabetes Australia Research Trust, of the Australian and New Zealand Society mechanisms of mineralocorticoid- General Research Grant. A novel of Nephrology in Perth. He also received mediated renal injury in approach for the early detection the Jacquot Research Establishment glomerulonephritis and diabetic of diabetic kidney disease. Award, administered by the Royal nephropathy. Huang L. 2010: Nikolic-Paterson DJ. 2010: Australasian College of Physicians $30,000 (PHI). $60,000 (PHI). ($90 000). Royal Australasian College of Kidney Health Australia, PhD Physicians, Post graduate scholarship. scholarship. Macrophage activation PUBLICATIONS, AWARDS, Vitamin D and Chronic Kidney Disease: in kidney disease and renal transplant effects on mineral metabolism, vascular rejection. Abu Abrahams. 2010: POSTGRADUATE STUDENTS calcification and transplant outcomes. $33,000. 2009-2011: $99,000 (PHI). AND FUNDING SUMMARY Damasiewicz M. 2010: $30,000 (Southern Health). Kidney Health Australia, PhD Journal articles 46 scholarship. TAK1 signalling in NHMRC, Project Grant. Identifying the macrophage-mediated kidney disease. Conference presentations 31 mechanistic basis of microalbuminuria Niroj Obeyesekere. 2010: $33,000. Awards 3 in diabetic nephropathy. Poronnik P and 2008-2010: $99,000 (PHI). Tesch GH. 2010: $74,440. 2009-2011: Postgraduate research students 8 $223,320 (RMIT). NHMRC, PhD scholarship. Signalling Pathways in Antibody-Mediated NHMRC, Project Grant. TAK1- a novel Renal Injury. Jessica Ryan (nee Funding: regulator of renal inflammation and Greenall). 2010: $27,298. 2009-2012: fibrosis. Nikolic-Paterson DJ and Tesch $102,625 (PHI). Competitive GH. 2010: $178,099. 2008-2010: NHMRC, Project. Plasma Exchange $534,298 (PHI). Commercial and Glucocorticoids in ANCA Amgen Associated Vasculitis: A Randomised NHMRC, Project Grant. Therapeutic targeting of MIF in type 2 diabetes. Control Trial (PEXIVAS Australia). Baxter Peh CA, Jayne D, Merkel P, Walsh M, Tesch GH and Nikolic-Paterson DJ. Langham R, Kerr PG. 2010: $201,500. 2010: $172,141. 2008-2010: Bristol Myer Squibb 2010-2012: $604,375 (University of $516,423 (PHI). Janssen-Cilag Adelaide). NHMRC, Senior Research Fellowship. Merck NHMRC, Project. Mechanisms of Nikolic-Paterson DJ. 2010: $123,750. 2009-2013 disease in humans with MPO-ANCA Novartis associated vasculitis. Holdsworth SR, : $618,750 (Monash University). Kitching R, Hickey M, Kerr PG. 2010: Roche NHMRC, Project Grant. Selective $175,00. 2010-2012: $514,500 targeting of acute renal injury by (Monash University). Other inhibition of the receptor tyrosine kinase,
Alports Foundation of Australia, Project c-fms. Nikolic-Paterson DJ, Tesch GH, Australasian Kidney Trials Network Ma FY. 2010: $142,400. 2010-2012: Grant. Novel stem cell assays for National Institutes of Health Alports Syndrome. SD Ricardo, PG Kerr. $427,200 (Monash University). 2010: $20,000. 2010-2011: $20,000 Raine Priming Grant (Monash University). Vifor Pharma
72 Southern Health Research Report 2010 73 RESEARCH GROUP REPORTS REPORTS GROUP RESEARCH Nephrology Nephrology RESEARCH GROUP REPORTS
Neurosciences
DIRECTOR: PROFESSOR DOMINIC THYAGARAJAN
The essence of being human resides in the brain – the most complex and poorly understood organ in the body and arguably the most sophisticated structure in the universe.
The brain is the focus of the clinical RESEARCH ACHIEVEMENTS Continuing strong performance of neurosciences. Diseases of the nervous the Huntington’s disease research system cause much of the burden of IN 2010 represented at Southern Health ill-health but recent advances in imaging, Engagement of a Professor of Clinical by Associate Professor Andrew therapeutics and molecular genetics are Neurosciences and Director of Churchyard. To demonstrate his at last providing inroads into the treatment Neurology. Professor Thyagarajan has international standing in the area, of some of the most intractable and now: established his own laboratory; Associate Professor Churchyard is devastating diseases in society. the only adult Mitochondrial Genetics the chief organiser of the World Clinic in Victoria (with a strong research Congress of Huntington’s Disease The Clinical Neurosciences Department focus); coordinated the Deep Brain which will be held in Melbourne in 2011. at Southern Health is large and very Stimulation Program across the This is the main research meeting in active in research with numerous Kingston and Monash Medical Centre Huntington’s disease research in the internal and external collaborators. campus (with a focus on NHMRC world. He has also been appointed to Neurological diseases include: stroke; supported cross-institutional research the seven-person Executive Organizing neurodegenerative disorders such as in the area), and has established Committee of Enroll HD, a multi-centre Alzheimer’s disease and other dementias, several key basic and clinical research international prospective study of the Parkinson’s disease and Huntington’s collaborative partnerships within natural history of Huntington’s disease disease; neuromuscular disorders such Southern Health, at Monash University, which is expected to enrol 15,000 as motor neuron disease, peripheral the Monash Institute of Medical subjects, commencing 2011. neuropathies, myopathies and muscular Research and CSIRO. dystrophies; neuroimmunological disorders such as multiple sclerosis; the epilepsies; Continuing strong research RESEARCH ACTIVITIES traumatic disorders of the nervous performance of the Stroke and Ageing system; a vast array of neurogenetic and Research Group. The group has Stroke and Ageing Research Group: neurometabolic disorders; developmental been substantially strengthened by The group has been successful in major disorders of the nervous system; brain the recruitment of Professor Mandy grant funding, publications and has now tumours; the headaches etc. Subspecialty Thrift, a stroke epidemiologist to the included two other large divisional groups clinics with research interests exist in all Monash Medical Centre, commencing joining in epidemiology and translational these areas. 2011. Professor Thrift will lead her public health (Professor Mandy Thrift). own independent research group The key figures from neurosciences are The department is particularly active but already has strong collaborations Associate Professors Velandai Srikanth in stroke research, neurodegenerative with the Stroke and Ageing Research and Than Phan. disorders, especially movement disorders Group, particularly Associate Professors such as Huntington’s and Parkinson’s Velandai Srikanth and Thanh Phan. disease, and epilepsy.
74 Southern Health Research Report 2010 75 RESEARCH GROUP REPORTS Neurosciences
Movement Disorders: IMS-III - A phase III, randomized, Funding: The research group is represented by multi-centre, open label, 900 subject Professor Dominic Thyagarajan, Associate clinical trial that will examine whether Competitive Professor Peter Kempster, Associate a combined intravenous (IV) and intra- NHMRC/NHF, CDA. Cerebrovascular Professor Andrew Churchyard. Professor arterial (IA) approach to recanalisation disease and dementia. V Srikanth. Thyagarajan and Associate Professor is superior to standard IV rt-PA 2010: $100,000. 2010-2014: $400,000 Churchyard’s activity are outlined above. (Activase/Actilyse®) alone when (Monash University). Professor Thyagarajan has moved from initiated within 3 hours of acute Adelaide where he continues to supervise ischemic stroke onset. NHMRC, Project Grant. Diabetes and his two PhD students, one holding a dementia. Srikanth V, Phan TG et al.
prestigious Endeavour Scholarship through Rocket (end 10/2010) - A prospective, 2010: $300,000. 2010-2015: $1.2 million Flinders University and one the recipient of randomized, double blind, double (Monash University). a Multiple Sclerosis Research Association dummy, parallel group, multicentre, Grant. Refurbishment of his laboratory event driven, noninferiority study NHMRC, Project Grant. STANDFIRM – a finished in 2010, he is taking a PhD student comparing the efficacy and safety secondary stroke prevention RCT using in 2011 and has established a key research of once daily oral Rivaroxaban (BAY shared CDM management between collaboration with Professor Justin St. 59-7939) with adjusted dose oral nurses, doctors and GPs. Thrift AG, John, the new Director of the Center for Warfarin for the prevention of stroke Cadilhac D, Srikanth V, Phan TG et al. Reproduction and Development at MIMR. and non central nervous system 2010: $300,000. 2010-2015: $1.6 million systemic embolism in subjects with (Monash University). non valvular atrial fibrillation. Current projects NHMRC, Postgraduate scholarship DIAS-3 - A randomised, double-blind, Cerebrovascular disease and dementia. (PhD). Immune study of stroke. Sanders parallel-group, placebo-controlled V Srikanth. l. 2010: $25,000. 2010-2013: $80,000 phase III study to evaluate the safety (Monash University). Diabetes and dementia. Srikanth V, and efficacy of desmoteplase in
Phan TG et al. subjects with acute ischemic stroke. Endeavour Scholarship, Postgraduate scholarship (PhD). A novel STANDFIRM (STANDFIRM – a Interact 2 - A randomised trial to mitochondrial DNA (mtDNA) mutation secondary stroke prevention RCT using establish the effects of early intensive significantly attenuates transcription shared CDM management between blood pressure lowering on death and termination in a patient with a nurses, doctors and GPs. Thrift AG, disability in patients with stroke due to mitochondrial myopathy. Raghupathi Cadilhac D, Srikanth V, Phan TG et al. acute intracereral haemorrhage. Ravinarayan. 2010: $30,000. 2007-2011: $120,000 (Flinders
Immune study of stroke. Sanders l. PrePARE- Prediction and Prevention to University). Achieve Optimal Recovery Endpoints A novel mitochondrial DNA (mtDNA) after stroke (Protocol NTA0902). Multiple Sclerosis Research Association mutation significantly attenuates of Australia, Postgraduate scholarship.
transcription termination in a patient Start-EXTEND - Stroke imaging Mitochondrial dysfunction in multiple with a mitochondrial myopathy. prevention and Treatment (START); sclerosis. Mark Slee. 2010: $20,000. Raghupathi Ravinarayan. Extending the time for Thrombolysis 2007-2010: $60,000 (Flinders in Emergency Neurological Deficits University). Mitochondrial dysfunction in multiple (EXTEND) – (NTA0901) Garfield - sclerosis. Mark Slee. Prospective, multi centre, international Commercial registry of male and female patients Gadovist (end 5/2010) - A Multicentre, newly diagnosed with atrial fibrillation. Sponsor: Merck Serono. Immune randomized, double-blind, crossover, study of stroke. Sanders, Srikanth, phase 3 study to determine the safety Phan, Sobey. and efficacy of gadobutrol 1.0 molar PUBLICATIONS, (Gadovist) in patients referred for Sponsor: Pfizer CVL. Data linkage contrast-enhanced MRI of the central POSTGRADUATE STUDENTS study of TIA. Choi, Srikanth, Phan. nervous system AND FUNDING SUMMARY Sponsor: Ipsen. TMS in cervical Perform (end 5/2010) - Prevention of Journal articles 22 dystonia. Gangadharan Ganesvaran, cerebrovascular and cardiovascular Lee, Raghav, Thyagarajan. events of ischaemic origin with Book chapters 3 terutroban in patients with a history Conference presentations 17 of ischaemic stroke or transient ischaemic attack. Postgraduate research students 5
74 Southern Health Research Report 2010 75 RESEARCH GROUP REPORTS
Nursing: Deakin - Southern Health Nursing Research
CHAIR OF NURSING: PROFESSOR BEVERLY O’CONNELL
The vision of the Deakin - Southern Health Nursing Research Centre is to be nationally and internationally recognised as a centre of excellence in nursing research in the areas of quality, safety and aged care.
The centre is staffed by clinical and RESEARCH ACHIEVEMENTS the predisposing factors for elderly academic staff from a number of residents presenting to emergency disciplines. This combination supports IN 2010 departments. In addition, interviews an eclectic approach to conducting Development and publication of the are being conducted with staff from high quality research that informs policy nine-module education series: Tri-focal both residential aged care and development, clinical practice, and Model of Care Education Program for emergency departments to explore education. The centre continues to Residential Aged Care. their perceptions of the reasons for grow with the appointment of Associate such referrals. It is anticipated that Professor Paul Bennett. The primary focus Receipt of the ‘Excellence in Nursing the findings will guide practice and of Associate Professor Bennett’s research and Midwifery – Research’ award at subsequent interventions developed is exercise, nutrition and self management, the 2010 Southern Health Nursing and to reduce the transfer of residents to particularly for people living with chronic Midwifery Awards. emergency departments. kidney disease, which will make a valuable
contribution to the nursing research Centre staff have published four Nurse Unit Managers (NUMs) play program at Southern Health. peer-reviewed articles in ERA A a pivotal role in the management ranked journals. of patient care and ward staff. An The Deakin – Southern Health Nursing exploratory study was conducted Research Centre has attracted to gain a rich understanding of the approximately $1.2 million in funding since RESEARCH ACTIVITIES challenges that NUMs face and its inception in 2006. The centre is part how they manage these challenges. of the School of Nursing and Midwifery The Deakin – Southern Health Nursing In addition, a survey of NUMs has at Deakin University that received an Research Centre focused on consolidating explored factors that contribute to a Excellence in Research for Australia (ERA) existing projects and submitting articles good shift and a bad shift. The most ranking of four, indicating that the research to be published in peer-reviewed journals. common findings pertaining to a conducted is above world standards. Several studies commenced that make an good shift were having enough time important contribution to improving patient to manage their workload and achieve care across Southern Health. outcomes, a positive work environment and ward team, and appropriate staffing The research team are conducting a levels. Conversely, multi-tasking, study to identify the reasons why people having too many deadlines, working are referred to hospital emergency overtime, and not achieving outcomes departments from residential aged were among the most commonly care facilities. Data on emergency reported factors contributing to a bad admissions from residential care shift. These findings will inform the to all Southern Health emergency development of specific interventions departments over a two year period are to support and develop NUMs in currently being analysed to highlight their complex roles.
76 Southern Health Research Report 2010 77 RESEARCH GROUP REPORTS Nursing: Deakin - Southern Health Nursing Research
The Tri-focal Model of Care education PUBLICATIONS, AWARDS, program for residential aged care was finalised. This model focuses POSTGRADUATE STUDENTS on developing culture change and AND FUNDING SUMMARY incorporates three major concepts: Journal articles 9 partnership-centred care, positive work environment, and evidence-based Books 9 practice. The model of care is dynamic and inclusive and acknowledges the Conference presentations 10 importance of building and sustaining relationships among all stakeholders Awards 1 in residential aged care (i.e., residents, Postgraduate research students 2 their family members, staff, students, and service providers). Funding: The Tri-focal education program will form the basis of the Teaching Competitive Nursing Home which is currently being Deakin University, Faculty Grant. implemented at Chestnut Gardens. Reasons for referral from residential Content from the Tri-focal model aged care facilities to hospital education program has been integrated emergency departments. Hawkins M, into the nursing curriculum at Deakin O’Connell B, Considine J. Anna V. University. The Tri-focal Model of Care 2010: $15,714. 2010-2011: $15,714 is being implemented and evaluated at (Deakin University). Chestnut Gardens. This evaluation has been supported by a grant of $20,000 Department of Health and Ageing, from Deakin University. National tender. Residential aged care continence assessment tool project. O’Connell B, Ostaszkiewicz J. 2010: $53,723. 2007-2010: $659,924 (Deakin University).
76 Southern Health Research Report 2010 77 RESEARCH GROUP REPORTS
Obstetrics and Gynaecology
DIRECTOR: PROFESSOR EUAN WALLACE
Southern Health is Victoria’s largest provider of women’s health services, performing more gynaecological surgery, including general gynaecology, gynaecology cancer, urogynaecology and advanced endoscopic surgery, and caring for more pregnant women and their babies than any other hospital in the state.
As expected for such a large service, and Gynaecology, was awarded PUBLICATIONS, Southern Health also leads innovation President of the International Federation in women’s health with such services of Fertility Societies (IFFS) for the POSTGRADUATE STUDENTS as the Victorian Fetal Therapy Service duration 2010-2013 – an organisation AND FUNDING SUMMARY and Victoria’s first publicly funded home of 59 member countries and around Journal articles 22 birth service. Supporting, informing, and 40,000 health professionals. This is sometimes challenging, our services are the first time in the 60 year history of Conference presentations 27 diverse and include a comprehensive the IFFS and its sister organisation program of basic and clinical research. – the Federation for International Postgraduate research students 7 Women’s health research at Southern Gynaecology and Obstetrics (FIGO) Health is principally coordinated through - that an Australian has been head of Funding: the two research centres of the Monash either body. University Department of Obstetrics and Competitive Gynaecology: The Ritchie Centre and The Centre for Women’s Health Research. RESEARCH ACTIVITIES Bill and Melinda Gates Foundation, The Ritchie Centre is the largest perinatal Grand Challenges Explorations Grant. research centre in Australia addressing Research is undertaken in all Melatonin – preventing asphyxia brain the key research themes of women’s branches of our specialty including injury. Prof Euan Wallace, Dr Suzie health, fetal and neonatal health, sleep, fetal medicine, ultrasound, twins, Miller. 2010: $100,000 (MIMR). and cell therapies. Both research centres clinical obstetric trials and clinical risk NHMRC, Development Grant. are strategic alliances between Monash management, urogynaecology, gynae Novel methods for promoting organ Institute of Medical Research (Monash oncology, reproductive medicine and development and growth. A/Prof University) and Southern Health. gynaecological endoscopy, menopause Sharon Ricardo, Prof John Bertram, and contraception. The department Prof Euan Wallace, Prof Graham Jenkin. collaborates with Prince Henry’s Institute, 2010: $120,750. 2010-2012: $383,250 Centre for Women’s Health Research, RESEARCH ACHIEVEMENTS (Monash University). IN 2010 Monash IVF and many national and international colleagues. Australian Nuclear Science & Commenced world’s first clinical trial of Technology Organisation, Grant. a new treatment for ectopic pregnancy. Differentiation of amnion epithelial cells: imaging changes in morphology and Awarded a Bill and Melinda Gates function. Dr Rebecca Lim, Prof Euan Foundation Grant for a new treatment Wallace (Primary Supervisor). 2010: for cerebral palsy. $45,000 (Monash University). Professor David L Healy, Chairman of the Monash Department of Obstetrics
78 Southern Health Research Report 2010 79 RESEARCH GROUP REPORTS Obstetrics and Gynaecology
Monash University, Strategic Grant BUPA, Research Grant. Damaged Commercial Scheme. Investigating the role of uterine receptivity as a cause of Preterm Prelabour Rupture Of Activin A as a causative agent in the prematurity. Prof David Healy. Membranes close to Term trial. oxidative stress of preeclampsia. 2010-2012: $235,672 (Monash Induction of labour versus expectant Dr Rebecca Lim, Prof Euan Wallace University). management in patients with preterm (Primary Supervisor). 2010: $40,000 prelabour ruptured membranes (Monash University). NHMRC, Project Grant. First Trimester Aetiology of Obstetric Diseases. (PPROM) between 34 and 37 weeks NHMRC, Project Grant. Preventing Prof Gregory Rice, Dr Stephen Tong, gestation. Professor Euan Wallace, preterm lung disease – a cell therapy Dr Harry Georgiou. 2010: $163,493. Professor Jonathan Morris. approach. Prof Euan Wallace, Prof 2008-10: $481,114 (University of Progesterone after previous preterm Graham Jenkin, Dr Tim Moss, Dr Suzie Melbourne). birth for the prevention of neonatal Miller, Dr Alex Veldman. 2010: $150,875. respiratory distress syndrome. Professor 2010-2012: $452,625 (Monash NHMRC, Clinical Career Development Euan Wallace, Dr Jodie Dodd, Professor University). Award. The early origins of diseases in pregnancy; developing new predictive Caroline Crowther, Dr Andrew McPhee. NHMRC, Project Grant. Treatment tests and biological insights. Dr Stephen Syntocinon (oxytocin) bolus or of cerebral palsy – an experimental Tong. 2010: $67,228. 2008-11: $265,181 Syntocinon (oxytocin) bolus plus approach. Dr Suzie Miller, Prof Euan (Monash University). Syntocinon (oxytocin) infusion at Wallace, Prof Graham Jenkin. 2010: elective caesarean section, a $193,099. 2010-2012: $579,297 NHMRC, Project Grant. Development of double-blind randomised controlled (Monash University). novel medical therapies to cure ectopic pregnancies. Dr Stephen Tong, Dr T trial. Ms Joanne Mockler, V. Malkoutzis, NHMRC, Project Grant. Preventing Johns. 2010: $172,974. 2010-2012: Professor Euan Wallace. Prenatal Brain Injury in Fetal Growth $513,827 (Monash University). Is vaginal birth after caesarean section Restriction. Prof Euan M Wallace, Dr (VBAC) being encouraged? A survey Suzanne L Miller, Prof Graham Jenkin, NHMRC, Medical Postgraduate of the information given to women Dr Grant R Drummond, A/Pr David W Scholarship. The development of following a primary caesarean section. Walker. 2010: $170,477. 2009-2011: therapeutics for pre-eclampsia. Ms Joanne Mockler, Professor Euan $508,254 (Monash University). Dr Kirsten Palmer, Dr Stephen Tong (Primary Supervisor). 2010: $35,750. Wallace. NHMRC, Project Grant. Antenatal 2010-2012: $107,750 (Monash Improving the diagnosis and treatment Screening for Fetal Abnormalities University). of women who present with ovarian in Indigenous Women: views of torsion. Annie Kroushev, L Warburton- Indigenous People and their Health RANZCOG, Arthur Wilson RANZCOG Eggerton, A Parera, B Vollenhoven. Care Providers. Dr Alice Rumbold, Fellowship. Dr Kirsten Palmer, Dr Stephen Tong (Primary Supervisor). Dr Jacqueline Boyle, A/Pr Sue Kildea, Randomised double blind placebo 2010: $60,000 (Monash University). Prof Euan M Wallace, Dr Robyn controlled trial on the effect of Thompson. 2010: $59,778. 2008-2010: Monash IVF, Research Grant. intraperitoneal ropivacaine on $373,205 (Menzies School of Health Identification of serum markers postoperative pain and recovery Research). predictive of OHSS. Dr Luk Rombauts. after diagnostic laparoscopy and hysteroscopy. N Frawley, R Jones, NHMRC, Project Grant. Role of Amnion 2010: $55,000 (Monash University). A Polyakov, B Vollenhoven. Derived Stem Cells in Reducing Lung ACH2, Grant. Neutralising antibody Fibrosis. Prof Alan Trounson, Dr Ursula to HIV-1 ENV from hyperimmune bovine Health differences between women with Manuelpillai, Prof Euan M Wallace, colostrum as a mucosal microbicide. premature menopause and typical-age Prof Graham Jenkin. 2010: $115,262. Damian Purcell, Dr Luk Rombauts. menopause. D Yap, E Farrell, A Vincent, 2008-2010: $349,485 (Monash 2010-2011: $177,000 (Monash B Vollenhoven. University). University). Establishment of primary cell cultures NHMRC, Project Grant. Control of NHMRC, Project Grant. Critical from human fetal tissues. S Hawes, A Uterine Contraction: Role of Interstitial role of proprotein convertase 6 in Elephanty, G Weston, B Vollenhoven. Cells. A/Pr Helena Parkington, Prof Euan human uterine epithelium for embryo Wallace, Dr Richard Lang, Prof Graham Factors influencing fibroid growth and implantation and clinical implications. Jenkin. 2010: $199,647. 2008-2010: development. P Rogers, M Zaitevska, Guiying Nie, Dr Luk Rombauts. 2010: $587,206 (Monash University). L Waldrip, B Vollenhoven. $210,906. 2010-2012: $632,718 (Monash University).
78 Southern Health Research Report 2010 79 RESEARCH GROUP REPORTS Obstetrics and Gynaecology
XCEL bladeless trocar versus Veress needle: a randomised controlled trial comparing 2 entry techniques in gynaecological laparoscopic surgery. T Manley, J Tsaltas, B Vollenhoven.
Depo-Provera and bone density abnormalities. S Fernando, G Demerstein, J Wark, W Polyakov, B Vollenhoven.
VH Harmonic Scalpel Trial - Are sutures required in VH? A RCT of the use of the harmonic scalpel vs the traditional clamp, cut and tie method for VH. A Fitzgerald, G Edwards, H Najjar, W Tan, B Vollenhoven.
Combination methotrexate and epidermal growth factor inhibition as a novel treatment to cure ectopic pregnancies: Phase I. Dr Stephen Tong, Dr T Johns, Prof Euan M Wallace.
Other Monash Institute of Medical Research Flagship Grant. Combination methotrexate and epidermal growth factor inhibition as a novel treatment to cure ectopic pregnancies: Phase I-II clinical trials. Dr Stephen Tong, Dr T Johns, Prof Euan M Wallace. 2010: $100,000 (MIMR).
Keith Fitzmaurice Research Bursary, Victorian Managed Insurance Authority (VMIA). Therapeutic antibody development: a potential treatment for pre-eclampsia. Dr Kirsten Palmer, Dr Stephen Tong. 2010: $25,000 (MIMR).
80 Southern Health Research Report 2010 81 RESEARCH GROUP REPORTS
Ophthalmology
DIRECTOR: ASSOCIATE PROFESSOR IAN FAVILLA
The Ophthalmology Department comprises 16 sessional consultant ophthalmologists, five registrars and an orthoptist providing ophthalmic clinical and surgical services.
Particular clinical focus is on the evaluation PUBLICATIONS, AWARDS, of cataract surgery outcomes to ensure a resource-efficient service providing the POSTGRADUATE STUDENTS highest quality of patient care. AND FUNDING SUMMARY
Journal articles 4
RESEARCH ACTIVITIES Book chapters 1
The pattern electroretinogram (PERG) Conference presentations 2 and primary open-angle glaucoma. D Ling, I Favilla, L Santamaria. Glaucoma, a disease of the eye often associated with raised intraocular pressure, may eventually result in irreversible loss of vision. Currently available treatments aim to reduce the intraocular pressure, though not all individuals with raised pressure (ocular hypertension) will go on to develop glaucomatous nerve damage. This study demonstrated that the PERG is able to distinguish between those with primary open-angle glaucoma and those who are visually normal, by providing a measurement of retinal ganglion cell function. Further research may determine whether the PERG has a role in distinguishing between ocular hypertension and glaucoma.
80 Southern Health Research Report 2010 81 RESEARCH GROUP REPORTS
Pathology: Anatomical
DIRECTOR: DR IAN SIMPSON
The Department of Anatomical Pathology is involved with research projects in collaboration with various clinical units at Southern Health, the Monash Institute of Medical Research and the Cancer Council of Victoria.
The research projects are based on Completed projects Project titled “Mantle Cell Lymphoma morphological analysis, which include – Treatment Outcomes and Prognostic
morphology on routine stains and Project titled “Evaluation of Lymphatics Markers”. Jonathan Tan, Beena Kumar, identification of protein expression using in the Human Placental Bed and Ian Simpson, Stephen Opat. Results monoclonal antibodies on tissue sections. Surrounding the Spiral Arterioles in analysed, compiled, presented at an The researchers in the department have Decidualised Endometrium”. Mila International Conference. been involved in interpreting /analysing Volchek, Jane Girling, Gendie Lash, both human and mouse pathology. Leonie Cann, Beena Kumar, Stephen Project titled “Whole Brain Radiotherapy The focus in the past year has been in Robson, Judith Bulmer, Peter Rogers. and Ara-C in consolidation post involving anatomical pathology registrars Project completed, results published. High-Dose Methotrexate is Important in Establishing Durable Disease and laboratory scientists in research Project titled “A dermatopathological Control in the Treatment of Primary projects, research publications and scoring system to quantify acute poster presentations. CNS Lymphoma: A Single Centre synchrotron microbeam and broad Observational Study”. Melody Abikhair, beam radiation damage to normal Hang Quach, Michael MacManus, Ron RESEARCH ACHIEVEMENTS mouse skin”. Priya Capuge, Jeffrey Freilich, Beena Kumar, Ian Simpson, Crosbie, Beena Kumar, Peter Rogers. Stephen Opat. Results analysed, IN 2010 Project completed, results accepted compiled, presented at an International for publication. Project titled “Evaluation of Lymphatics Conference. in the Human Placental Bed and Project titled “Optimal Management Project titled “EUS-FNA: A review of a Surrounding the Spiral Arterioles in of Primary Central Nervous series of 101 consecutive procedures Decidualised Endometrial”. Project System Lymphoma (PCNSL) in at Monash Medical Centre. Greg Young, completed and results published. Immunocompetent Patients, a Kasturi Vaska, Christopher Desmond. Retrospective Study”. Melody Abikhair, Project titled “A dermatopathological Project completed, results being Michael MacManus, Ron Freilich, Beena analysed. scoring system to quantify acute Kumar, Ian Simpson, Stephen Opat. synchrotron microbeam and broad Results analysed, compiled, presented Project titled “A retrospective cohort beam radiation damage to normal at an International Conference. study to explore the influence of mouse skin”. Project completed and Biological Markers (CD44+/CD24- results accepted for publication. Project titled “Primary CNS lymphoma cancer stem cells) on the risk of MRI features: A retrospective study”. Various projects in collaboration with recurrence in Non Small Cell Lung Patel, Dee Nandurkar, D Anderson, Cancer. Muhammad Alamgeer, Beena the Clinical Haematology Unit were Beena Kumar, Anthony Kelmann. undertaken, results analysed and Kumar, Tracey Brown, Neil Watkins, Results analysed, compiled, presented Vinod Ganju. Project completed, presented at different national and at an International Conference. international conferences. results being compiled for publication.
82 Southern Health Research Report 2010 83 RESEARCH GROUP REPORTS Pathology: Anatomical
Project titled “Detection of lymphatic invasion in breast core biopsies using D2-40 immunohistochemistry”. Yvette Beaber, Lucy Webster, Beena Kumar, Piero Nelva, Mila Volchek, Stewart Hart. Project completed, results being analysed.
Current projects Correlative Studies in Lymphoid Cancer. Stephen Opat, Beena Kumar, Ian Simpson, Hang Quach.
Evaluation of immunohistochemical markers to predict tumour response to neoadjuvant chemotherapy in breast cancer. Vinod Ganju, Beena Kumar, Peter Midolo, Jane Fox, Leonie Cann, Zdenka Prodanovic, Alexandra De Gusclin, John Stuckey, Peter Rogers, Stewart Hart.
Mortality prediction in high-grade prostate carcinoma. Anthony Longano, Graham Giles.
ErbB4 expression in glioblastoma multiforme. Anthony Longano, Johns T.
Emphysema in gp130 F/F mouse mode. Anthony Longano, Jenkins B.
PUBLICATIONS SUMMARY
Journal articles 7
Conference presentations 20
82 Southern Health Research Report 2010 83 RESEARCH GROUP REPORTS
Pathology: Biochemistry
UNIT HEAD: DR JAMES DOERY
Research within the Biochemistry Unit makes heavy use of the extensive data generated through routine activity and is broadly focussed around the service and clinical functions of the laboratory including method development, data mining, audits and case reports.
Only a limited number of projects required Completed achievements A new collaboration with Associate external funding and substantial labour Professor Andis Graudins has
associated with projects is provided by Research activity may be classified developed an in vitro protocol to assess highly motivated staff on a voluntary into 4 areas, namely research involving the potential for intralipid therapy to after-hours basis. A number of other hypothesis driven testing, research treat various drug toxicdromes. The projects have been pursued by based on data mining of existing results results of this work will now be used as collaborations with other departments held in the laboratory information a basis to perform animal studies with within or external to Southern Health. system or transferred into specific data drugs demonstrating potential for such bases and collaborative work with therapy in the in vitro model. clinical units to develop best practice RESEARCH HIGHLIGHTS guidelines based on literature review In collaboration with the Thalassemia and review of existing investigational Service we are undertaking a cross IN 2010 protocols. In addition the Pathology sectional study of bone health in Publication by Dr Zhong Lu and Department provides a Special & transfusion dependant thalassemia colleagues on ‘HbA1c for screening Routine Analytical Service to support a patients. and diagnosis of Type 2 diabetes in large number of projects conducted by routine clinical practice’. This work is other clinical units and researchers. PUBLICATIONS, AWARDS contributing to a growing acceptance of A number of notable publications have HbA1c as a definitive diagnostic test for involved members of the Biochemistry AND POSTGRADUATE diabetes and provides the possibility of Unit this past year including: A study STUDENTS SUMMARY greatly reducing the number of glucose report by Dr Zhong Lu and colleagues Journal articles 4 tolerance tests done in patients with on ‘HbA1c for screening and diagnosis suspected diabetes. of Type 2 diabetes in routine clinical Conference presentations 25 Sixteen conference presentations, practice.’ This work is contributing to including one on pseudothyroxinemia a growing acceptance of HbA1c as a Awards 2 in a neonatal ICU patient due to definitive diagnostic test for diabetes Postgraduate research students 2 biotin therapy which won a ‘Best and provides the possibility of greatly Poster Award’. reducing the number of glucose tolerance tests done in patients with A conference presentation titled suspected diabetes. ‘How equivocal is a sweat chloride of 40-60 mmol/L? An audit of over A conference presentation titled ‘How 1,600 serial analyses’ revealed an equivocal is a sweat chloride of 40-60 unexpectedly high incidence of mmol/L? An audit of over 1,600 serial patients with atypical forms of CF analyses.’ revealed an unexpectedly and congenital absence of the vas high incidence of patients with atypical deferens when sweat choride was in forms of CF and congenital absence of the equivocal range. the vas deferens when sweat choride was 50-60 mmol/L. Another conference presentation on pseudothyroxinemia in a NICU patient due to biotin therapy won a ‘Best Poster Award’. 84 Southern Health Research Report 2010 85 RESEARCH GROUP REPORTS
Pharmacy
DIRECTOR: MR IAN LARMOUR
The Pharmacy Department is involved in a wide variety of activities to promote medication safety and the quality use of medication.
A primary goal of the department is CONFERENCE continuous quality improvement which requires the development of new PRESENTATIONS AND systems and practices which need to POSTGRADUATE STUDENTS be evaluated and refined and which SUMMARY drives the department’s research focus. Conference presentations 15
RESEARCH ACTIVITIES Postgraduate research students 1
Research themes for the department have focused on the following issues:
The introduction and evaluation of interim medication charts for patients being transferred to nursing homes.
Significant work was also done in relation to prescribing training and evaluation for intern medical staff.
Other projects related to specific areas of practice, such as the role of pharmacists in outpatient clinic; antimicrobial management roles.
Considerable progress has also been achieved in relation to staff credentialing for clinical services and dispensing Therapeutic Drug Monitoring and evaluating the data contained in the department’s Adverse Drug Reaction database.
84 Southern Health Research Report 2010 85 RESEARCH GROUP REPORTS
Respiratory and Sleep Medicine
DIRECTOR: PROFESSOR PHILIP BARDIN
DIRECTOR OF SLEEP RESEARCH: DR CARLIN HAMILTON
DIRECTOR OF RESPIRATORY DISEASE RESEARCH: DR PAUL KING
Respiratory and Sleep Medicine considers research as a key component of departmental activities. Virtually all staff are involved in some aspect of original investigation.
In 2009 the department appointed research RESEARCH ACTIVITIES Bronchiectasis research programme directors in Sleep (Dr Garun Hamilton) and under the leadership of Dr Paul King Respiratory Disease (Dr Paul King). This Asthma research studies of vocal cord has continued to publish novel findings initiative has provided leadership in areas dysfunction in difficult-to-treat disease based on studies of our large cohort of research targeted by the department. have continued in 2010. Using the of >200 patients. Dr King was also new Southern Health/Monash Medical invited to provide several lectures in Respiratory research at Southern Health Centre 320-slice Toshiba Aquilion CT the this field at various scientific meetings. has concentrated on asthma, chronic researchers were able to quantifiy this
obstructive pulmonary disease (COPD) troublesome condition for the first time. Asthma virus exacerbation and bronchiectasis under a theme of A recent paper has been accepted in programme has continued a research airway inflammation. Both clinical and the American Journal of Respiratory and programme that has linked with the basic science components form part of Critical Care Medicine, the most highly Innate Immunity Group in MIMR headed this programme. In addition, there is an ranked journal in this field. Ongoing by Professor Paul Hertzog. The senior active clinical trials unit conducting phase studies will examine the prevalence of post-doctoral scientist, Dr Belinda 1B – phase 3 trials in asthma and COPD. ‘asthma of the voice-box’ in patients Thomas, received an Asthma Victoria with severe asthma admitted to the Research Grant for 2010 as well as Research in sleep medicine is focussed emergency department. Dr Kathy Low prizes for presentations at the TLROZ on various aspects of sleep disordered had received an Emerging Researcher meeting in Queensland and Monash breathing (sleep apnoea). Phenotypic Fellowship for 2010 from Southern Institute of Medical Research meetings. and functional facets are investigated Health for this research. The department has continued work employing clinical studies in tandem on a virus and asthma NHMRC Project with basic science studies. These studies COPD research program in Grant in collaboration with Dr Reena are done in collaboration with the Ritchie collaboration with Associate Professor Ghildyal and Professor David Jans at Centre at Monash Medical Centre and Brendan Jenkins (MIMR) was expanded Monash University. the Monash Institute of Medical Research. after receiving a NHMRC Project Grant
in 2009. These studies have used a Sleep Research program is headed The department is committed to delivery new mouse model to study pathways by Dr Garun Hamilton. A number of of high level clinical care to patients with to COPD disease and to examine studies are currently underway, respiratory and sleep disorders. It is new therapies. This has culminated in mostly in their early stages. Two believed that this is best achieved through a recent publication in the American NHMRC funded studies are continuing. an active research programme that Journal of Respiratory Cell and The first is performed in collaboration emphasises new treatment developments Molecular Biology. Nutritional aspects with the Ritchie Centre and the Alfred which encourage physicians and staff to of COPD have been investigated in Hospital, and is investigating the control keep abreast of the latest developments. collaboration with the Department of mechanisms underlying respiratory Ultimately that it is the key to evidence- Human Nutrition headed by Associate instability in central sleep apnoea. based practice and high-level clinical care. Professor Boyd Strauss. Patient recruitment is continuing and the first manuscript is about to be submitted.
86 Southern Health Research Report 2010 87 RESEARCH GROUP REPORTS Respiratory and Sleep Medicine
The second is collaboration with the PUBLICATIONS AND Commercial Woolcock Institute of Medical Research Boehringer Ingelheim (Sydney University) and Prince Henry’s FUNDING SUMMARY Institute. It involves a randomised Journal articles 13 Clinical Network Services controlled trial of both CPAP and Vardenafil in men with both obstructive Book chapters 2 GlaxoSmithKline sleep apnoea and erectile dysfunction.
Both of these are in their first year of Merck recruitment. Other studies include sleep Funding: Novartis apnoea phenotyping work, looking Competitive at the role of lung volume and upper Schering Plough airway morphology in different patterns NHMRC, Project Grant. COPD of obstructive sleep apnoea (OSA). mouse model. Jenkins B, Bardin P. Trident The department continues to participate 2010: $180,000. 2008-2010: in the SAVE trial, a multi-centre, $600,000 (MIMR). Other international randomised controlled trial NHMRC, Project Grant. Rhinovirus • Emerging Researcher Fellowship. to determine whether CPAP treatment nuclear trafficking. Ghildyal R. 2010: Asthma and VCD. Dr K Low. reduces mortality and cardiovascular $190,000. 2009-2011: $660,000 2010: $30,000 (Southern Health). events in patients with moderate-severe (Monash University). OSA. Other studies about to (or just) commencing include the measurement NHMRC, Project Grant. Quantifying of energy expenditure in OSA, loop-gain. Berger P, Hamilton G. categorising OSA into rigid phenotypes, 2010: $200,000. 2010-2012: clinical trials in insomnia and the $600,000 (MIMR). validation of a new CPAP device. Monash University, Strategic grant. Clinical Trials Unit under leadership of Monash University Sleep Health Ms Joanne McKenzie has maintained a Study. Hamilton G et al. 2010: high level of research activity. A highlight $55,000 (MIMR). was completion of a phase 2 study in asthma investigating a new Il-5 antibody Monash University, NHMRC Equipment administered intravenously and Monash Grant. Actigraphy and Energy Medical Centre was the top recruiting Expenditure Equipment. Hamilton G, centre for this trial. The demand for O’Driscoll D, Strauss, B et al. 2010: the units services continue to expand $20,000 (MIMR). and space is urgently required. It is NHMRC, Project Grant. RSV M-protein hoped that the new Monash Health trafficking. Jans D, Bardin P. 2010: Translation Precinct will provide $250,000. 2010-2012: $750,000 additional opportunities for growth in (Monash University). clinical trials and clinical research. Monash University, Strategic grant. Lung response to NTHi. King P. 2010: $35 000 (Monash University).
86 Southern Health Research Report 2010 87 RESEARCH GROUP REPORTS
Rheumatology
DIRECTOR: ASSOCIATE PROFESSOR GEOFFREY LITTLEJOHN
The department co-ordinates clinical care, teaching, training, and research into a wide range of disorders affecting the musculoskeletal system.
These include inflammatory, degenerative Researchers were able to demonstrate As well as these scientifically-orientated and painful disorders affecting bone, joint, for the first time in human lupus that studies, the lupus clinic continues to muscle, blood vessels and other organs lupus patients’ white blood cells have develop its data gathering function, of the body. abnormal behaviour when placed in whereby on consenting patients clinical circumstances similar to a flowing data is collected and matched to blood vessel. Lupus patients’ white serum and urine samples for ongoing RESEARCH ACTIVITIES blood cells demonstrate increased biomarker studies. The long term goal spreading – a readout of their is a large database of prospective data The department conducts international tendency to migrate – suggesting with matching samples for such studies, collaborative clinical trial research that inflammation in lupus is partly together with the possibility of forming focussing on novel treatments in Phase explained by altered white blood cell a national cooperative research II/III development, principally in rheumatoid behaviour. This work was presented database in lupus. arthritis, systemic lupus erythematosus, at the prestigious American College osteoarthritis and fibromyalgia. The of Rheumatology Annual Scientific outcomes of these trials have resulted in Meeting. Scleroderma Clinic a large number of new and more effective Joanne Sahhar (Head of Clinic) , treatments to become available for Researchers demonstrated that Gene-Siew Ngian and Kathleen Elford Australian patients. the cytokine IL17, a molecule contributed data to the Australian which promotes immune system Scleroderma Databank and studying Investigator-driven studies derive from five abnormalities, is increased in lupus vascular reactivity in scleroderma. specialty clinics combining clinical care patients who have lupus effects on with database driven and related research. their brain. This suggests that anti-IL 17 treatment might be best used in Fibromyalgia Clinic Lupus Clinic such patients. Emma Guymer (Head of Clinic), Professor Eric Morand (Head of Clinic), Researchers also measured the serum Kathleen Elford, Geoff Littlejohn, Alberta Hoi, Sue Morton and Sarah levels of two other cytokines, BLyS conducted prospective studies of Bode, are examining cytokine profiles and APRIL, and showed that these treatment outcomes and triggering factors and disease activity and outcomes. two are elevated in some subsets of in fibromyalgia. Additional fibromyalgia The Lupus Clinic is Australia’s only lupus patients. As anti-BLyS treatments studies examining psychological factors dedicated clinic for patients with systemic are nearing clinical application, this in fibromyalgia in conjunction with lupus erythematosus (SLE). Its research may allow the selection of patients for Katrina Malin, PhD student. focus is on better outcomes for patients, therapy. and on identifying markers of disease
activity with a view to identifying future In another study, researchers examined therapeutic targets. the association of genetic variation in a pro-inflammatory gene known as MIF with specific forms of lupus renal disease and showed a strong trend towards an association. Greater numbers of patients are required in order to learn if this finding is robust.
88 Southern Health Research Report 2010 89 RESEARCH GROUP REPORTS Rheumatology
Rheumatoid Arthritis Clinic A Randomised, Double-Blind, A randomized, double-blind, International Study To Evaluate placebo-controlled, multicenter, Associate Professor Michelle Leech The Efficacy And Safety Of Various two-part, dose ranging and confirmatory (Head of Clinic), Professor Eric Morand, Re-treatment Regimens Of Rituximab study with an operationally seamless Sue Morton, conducting long-term In Combination With Methotrexate design, evaluating efficacy and safety observational outcome studies on a large In RA Patients With An Inadequate of SAR153191 on top of methotrexate cohort of patients. Additional rheumatoid Response To Methotrexate. Sponsor: MTX in patients with active rheumatoid arthritis studies include collaboration Roche. Littlejohn G. 2010: $13,440 arthritis (MOBILITY). Sponsor: Sanofi- with the OPAL Australian wide database (Southern Health). Aventis. Littlejohn G. 2010: $4,500 (Chairman Steering Committee Geoff (Southern Health). Littlejohn) studying factors contributing Multicenter, Randomised, Double-blind, to remission in 2,000 rheumatiod Placebo-controlled Trial of golimumab, A multi-center, uncontrolled extension arthritis patients. a Fully Human Anti-TNFα monoclonal study evaluating efficacy and safety Antibody, Administered Subcutaneously, of SAR153191 on top of DMARDs in Psoriatic arthritis clinic in Subjects with Active Rheumatoid patients with active Rheumatoid Arthritis Despite Methotrexate Therapy. Arthritis (RA) (ABILITY). Sponsor: Sally Ayoub (Head of Clinic) conducting Sponsor: Centecor. Littlejohn G. 2010: Sanofi- Aventis. Littlejohn G. 2010: database derived observational $27,405 (Southern Health). $3,300 (Southern Health). prospective research on a cohort of Randomized, Double Blind, Parallel- patients with psoriatic arthritis. Group Study Of Cardiovascular Safety In Osteoarthritis or Rheumatoid PUBLICATIONS, Arthritis Patients With or at High Risk for Cardiovascular Disease Comparing POSTGRADUATE STUDENTS Celecoxib With Naproxen and AND FUNDING SUMMARY Ibuprofen. Sponsor: Pfizer. Littlejohn G. 2010: $2,170 (Southern Health). Journal articles 7 Multicenter, Randomized, Double- Book chapters 3 Period, Double-Blind Study to Conference presentations 18 Determine the Optimal Protocol for Treatment Initiation with Methotrexate Postgraduate research students 3 and Adalimumab Combination Therapy in Patients with Early Rheumatoid Funding: Arthritis. Sponsor: Abbott. Littlejohn G. 2010: $12,978 (Southern Health). Commercial A randomised, double-blind, A prospective multi centre, randomised, placebo-controlled, multicentre double-blind, active comparator- prospective dose-finding Phase controlled, parallel groups study II/III study with atacicept given comparing the fully human anti-TNF subcutaneously to subjects having antibody D2E7 given every second recently experienced a flare of systemic week with methotrexate given weekly lupus erythematosus (SLE). Sponsor: and the combination of D2E7 and Merck Serono. Littlejohn G. 2010: methotrexate administered over 2 $1,896 (Southern Health). years in patients with early rheumatoid arthritis. Sponsor: Abbott. Littlejohn G. Extension Phase of the Multi-National 2010: $10,950 (Southern Health). Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of An open label study of the efficacy and Tocilizumab in Patients with Active safety of re–treatments with rituximab in Rheumatoid Arthritis on Background patients with active rheumatoid arthritis. Non-biologic DMARDs who have Sponsor: Roche. Littlejohn G. 2010: an Inadequate Response to Current $11,620 (Southern Health). Non-biologic DMARD and/or Anti-TNF Therapy. Sponsor: Roche. Littlejohn G. 2010: $31,800 (Southern Health).
88 Southern Health Research Report 2010 89 RESEARCH GROUP REPORTS
Supportive and Palliative Care
DIRECTOR: ASSOCIATE PROFESSOR KATE JACKSON
The Supportive and Palliative Care Unit aims to improve symptom control, end of life care and provide support to patients/families and other health care professionals for patients with incurable disease.
The Unit’s current major research focus PUBLICATIONS AND is refractory cancer pain and auditing of the Pathway for Improving the Care of the PRESENTATIONS SUMMARY Dying rollout across Southern Health. Journal articles 4
Conference presentations 13 RESEARCH ACTIVITIES
“Pathway for Improving the Care of the Dying (PICD) in general hospital wards”. Ongoing teaching, support and auditing at Southern Health and into Gippsland.
An audit of subcutaneous lymphoedema drainage in palliative care patients with refractory lymphoedema.
An audit of the effects of ketamine (including any effect on depression) in palliative care patients with pain.
Aesthetics in Palliative Care – with an Artist in Residence at McCulloch House.
Audit of the Palliative Prognostic Index Melbourne Modification (PPIMM) (K. Jackson, AD (Sandy) Macleod, P. Poon, L. William, M. Franco).
QT Auditing in Palliative Care Patients on Methadone. K. Jackson, A. Somogyi, P. Poon, M. Franco, L. William.
“The Disambiguation Room” developed by Efterpi Soropos, Human Rooms™ - Artist in Residence, McCulloch House
90 Southern Health Research Report 2010 91 RESEARCH GROUP REPORTS
Urology
DIRECTOR: ASSOCIATE PROFESSOR MARK FRYDENBERG
The Urology Department consists of a dedicated team who are committed to the multifaceted conduct of research.
The research focus of the department is curative treatment and avoids the Funding: diverse with data analysis ranging from associated morbidity, in particular retrospective audits; assessment of the incontinence and impotence, of Commercial prevalence of particular syndromes; surgery and radiotherapy. Sunitinib; treatment of Renal Adjuvant laboratory work and meta-analysis of cancer (S-TRAC): A randomized published studies. There is a strong Self reported competence of urethral catheterisation in interns. Principal double-blind phase III study of Adjuvant commitment to focus on clinical trials Sunitinib versus placebo in subjects which aim to increase the treatment investigators: Matthew Winter, Paul Manohar, Sree Appu and Phil McCahy. with high-risk Renal Cell carcinoma. options available to our patients. Sponsor: Pfizer. Principal investigaror: Percutaneous antegrade ureteroscopy; Frydenberg M. (Southern Health). Current projects A novel approach to the ureter.
Principal investigators: Matthew A Phase 3, Randomized, Double-Blind, A randomised trial to compare Winter, Ciaran Lynch, Sree Appu Placebo - Controlled, Parallel-Design, transurethral prostatectomy (TURP) and John Kourambas. Global Multicenter Study to Evaluate and 120W photoselective vapourisation the Efficacy and Safety of Tadalafil of the prostate (PVP) in men with lower Renal carcinoma with inferior vena Once Daily Dosing for 12 Weeks in Men urinary tract symptoms. Principal cava tumour thrombus: An Australian with Signs and Symptoms of Benign investigator: Phil McCahy. experience. Principal investigators Prostatic Hyperplasia. Sponsor: Eli Lilly. Matthew Winter, Chia Pang and Principal investigaror: Frydenberg M. HOLEP in anticoagulated patients. Sree Appu. (Southern Health). Principal investigators: Conrad Bishop, Heath Liddel, Joseph Ischia and Double-blind, Placebo Controlled Trung Pham. This study demonstrated Awards Study to Evaluate New or Worsening that Holmium Laser Enucleation Lens Opacifications in Subjects with Prostatectomy (HOLEP) is safe in Urological Society of Australia & New Non-Metastatic Prostate Cancer anticoagulated patients thereby Zealand Victorian Country Meeting Best Receiving Denosumab for Bone Loss avoiding all the financial and labour Paper 2010: Matthew Winter due to Androgen-Deprivation Therapy. costs associated with temporarily Sponsor: Amgen. Principal investigaror: stopping these increasingly common Frydenberg M. (Southern Health). medications. PUBLICATIONS, AWARDS AND FUNDING SUMMARY A phase 2 Clinical Study to Evaluate Active surveillance for prostate Daily Oral Doses of LY500307 for cancer. Principal investigators: Journal articles 4 24 weeks in Men with Lower Urinary Chia Pang, Joseph Ischia, Yeng Tract Symptoms (LUTS) and Prostatic Book chapters 2 Kwang Tey, Christopher Li Wai Suen, Enlargement Secondary to Benign Hau Choong Aw and Mark Frydenberg. Conference presentations 10 Prostatic Hyperplasia (BPH). Sponsor: Active surveillance is the expectant Eli Lilly. Principal investigaror: management of men with low-risk Awards 1 Frydenberg M. (Southern Health). prostate cancer. It appears to be a safe alternative to immediate
90 Southern Health Research Report 2010 91 RESEARCH GROUP REPORTS Urology
A randomized, double-Blind, Phase III Trial to compare the efficacy of Ipilimumab vs. Placebo in Asymptomatic or Minimally Symptomatic Patients with Metastatic Chemotherapy-Naïve Castration Resistant Prostate Cancer. Sponsor: BMS. Principal investigaror: Pook D. (Southern Health).
The uRNA® detection study. A prospective study of a novel diagnostic test for the detection of Urinary Tract Transitional Cell Carcinoma (TCC). Sponsor: Pacific Edge Biotech. Principal investigaror: Frydenberg M. (Southern Health).
A randomized, double-blind, placebo- controlled, multi-centre phase 3 study of Denosumab on prolonging bone metastasis-free survival in men with hormone-refractory prostate cancer.” Sponsor: Amgen. Principal investigaror: Frydenberg M. (Southern Health).
92 Southern Health Research Report 2010 93 RESEARCH GROUP REPORTS
Vascular Sciences
DIRECTOR: PROFESSOR BARRY MCGRATH
The department provides clinical and diagnostic services and undertakes research into vascular disorders.
Research activity is broadly related RESEARCH ACHIEVEMENTS The placebo controlled clinical trial to furthering our understanding of the was established and 20 patients have mechanisms affecting arterial function, IN 2010 completed the study. There have been including endothelial function, prevention In 2010 Cathy Martin (PhD student) no significant adverse events recorded. of arterial disease and improving clinical published a key paper identifying Investigators for this study: B McGrath management of patients suffering from glucose intolerance as an important and S Chen (Dept Vascular Sciences), vascular disease. The department has biomarker in patients with isolated clinic H Schmidt and K Wingler (Uni of a referral service for ambulatory blood (white coat) hypertension and showed Maastricht, the Netherlands). pressure monitoring and is a leading that this was not due to co-existing Analysis of the Australian ambulatory centre for research in this area. Southern metabolic syndrome features. Health vascular ultrasound is performed blood pressure database has led to in the department as is ultrasound-guided The department contributed to an the development of a new position venous sclerotherapy. Australian database of ambulatory paper on ambulatory blood pressure blood pressure monitoring and monitoring developed by a working The department also supports other evaluation of the relationship to clinic group under the auspices of the Southern Health clinical research groups blood pressure for defining diagnostic National Heart Foundation and the including heart failure and emergency and therapeutic targets. This work High Blood Pressure Research Council department research groups. In 2011 was published in the BMJ. of Australia. Professor McGrath Neurosciences will commence a weekly presented this position paper in TIA clinic in the department. It will also Dec 2010 and it is to be published in become a site for the NIH-NHMRC funded RESEARCH ACTIVITIES mid 2011. This work has been quoted ASPREE study conducted by Monash by the National Institute of Health and School of Public Health. NHMRC-funded investigator led clinical Clinical Excellence (NICE-UK) in new trial of L-citrulline versus placebo in hypertension guidelines. patients with peripheral arterial disease
has progressed well. This project has A study of more than 100 untreated been the first study in humans to look subjects has evaluated a broad at the potential benefit of restoring range of biomarkers in patients endothelial function with priming of the with hypertension. Baseline studies Nitric Oxide pathway in patients with were completed in 2010 and results peripheral arterial disease, using an oral presented at the International Society of amino acid supplement and a naturally Hypertension meeting and published. occurring co-factor. Basic laboratory research studies were completed to study the human enzyme involved in the pathway and to assay key components.
92 Southern Health Research Report 2010 93 RESEARCH GROUP REPORTS Vascular Sciences
PUBLICATIONS, A multi-centre, randomized, double-blind, placebo and active POSTGRADUATE STUDENTS controlled, parallel group, dose finding AND FUNDING SUMMARY study to evaluate the efficacy and safety of LC1699 compared to placebo Journal articles 5 after 8 weeks treatment in patients Conference presentations 6 with essential hypertension. Sponsor: Novartis Pharmaceuticals Australia. Postgraduate research students 1 Investigator: McGrath, B.
Cardiovascular Outcomes in Renal Funding: Atherosclerotic Lesions (CORAL). Randomised and Multi-Centre Competitive Two-Group Clinical Trial to Assess NHMRC, Project Grant. the Best Treatment for Patients with Pharmacological Effects of Oral High Blood Pressure and Renal L-Citrulline and Tetrahydrobiopterin in ArteryStenosis: Stenting with Patients with Peripheral Artery Disease. Anti-Hypertensive Medical Therapy, McGrath B, Schmidt H, Wingler K. Compared to Medical Therapy Alone. 2010: $63,500. 2009/2010: $312,000 Sponsor: University of Toledo, USA. (Monash University). Investigator: Burnes, J., Kerr, P., McGrath, B, Jackson B. Commercial ARISTOTLE: A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects with Nonvalvular Atrial Fibrillation. Sponsor: Bristol-Myers Squibb. Investigator: Jackson, B.
94 Southern Health Research Report 2010 95 MONASH HEALTH TRANSLATION PRECINCT PARTNER REPORTS
Monash Institute of Medical Research
DIRECTOR: PROFESSOR BRYAN WILLIAMS
The Monash Institute of Medical Research (MIMR) undertakes multidisciplinary research into stem cells, inflammatory diseases, cancer, women’s and child health, and reproduction and development.
MIMR was established in 1991 (as the Centre for Reproduction and Health Translation Precinct (MHTP), in Monash Institute of Reproduction and Development partnership with Southern Health, Prince Development) by Emeritus Professor Henry’s Institute and Monash University’s David de Kretser AC and Professor The Ritchie Centre clinical departments. The precinct partners Alan Trounson. have an emphasis on translational MIMR’s research programs have led to research, integrating basic research with ground-breaking advances in assisted Research at MIMR is conducted in four clinical studies in order to accelerate human reproduction, the reduction of SIDS research centres: the transition into improved health and advances in stem cell research. outcomes. MIMR is able to streamline Centre for Cancer Research The Institute’s innovative research is highly the development of improved treatments Centre for Innate Immunity and collaborative, and is assisted by its location targeted to patients’ clinical needs. Infectious Diseases at Southern Health’s Monash Medical Centre. MIMR is a member of the Monash
94 Southern Health Research Report 2010 95 MONASH HEALTH TRANSLATION PRECINCT PARTNER REPORTS Monash Institute of Medical Research
KEY RESEARCH KEY FUNDING HIGHLIGHTS 2010 RESEARCH OVERVIEW
ACHIEVEMENTS IN 2010 IN 2010 The Centre for Cancer Research is led Using synchrotron technology, The Monash Health Translation Precinct, by Institute Director, Professor Bryan Professor Stuart Hooper from the led by the Monash Institute of Medical Williams. Scientists working in the Ritchie Centre devised a way of Research, received $1.6 million in Centre undertake basic research into monitoring lung motion, and for the funding from the Australian Cancer the molecular mechanisms underlying first time, could show the difference Research Foundation (ACRF) the development, growth and in motion within both healthy and to establish the ACRF Centre for Cancer metastasis of tumours, as well as the diseased regions of the lung. This will Genomic Medicine. The new Centre relationship between the innate immune greatly improve understanding of the will allow researchers to expand their system and cancer. The discovery and mechanisms of lung diseases, such genetic profiling of specific cancers; development of novel therapeutics as asthma. Professor Hooper’s team information critical to the development for the treatment of cancers is also an received a US $750,000 grant from the and application of anti-cancer drugs important aspect of the Centre’s work. American Asthma Foundation to exploit tailored to individual patients. The grant, The Centre’s research groups focus this technique, by gaining a more one of only three awarded in Australia, on cancer and innate immunity; detailed and specific understanding of will be used to purchase the latest in cancer metastasis; cell adhesion the pathology of asthma, how it occurs, DNA sequencing technologies, which signalling; oncogenic signalling; and how it responds to treatment. will enable researchers and clinicians cancer and developmental biology; to introduce molecular-based patient gut regeneration; structural biology; Dr Richard Ferrero, from the Centre tumour profiles for everyday cancer pain medicine; and a Phase I Clinical for Innate Immunity and Infectious patient management. Trials Program. Diseases, led a team that discovered that the Helicobacter pylori bacteria, In 2010, the State Government and the Led by Professor Paul Hertzog, which is responsible for peptic ulcers Victorian Cancer Agency (VCA) awarded the Centre for Innate Immunity and and some forms of stomach cancers, $3 million for the Victorian Lung Cancer Infectious Diseases researches the needs vitamin B6 to flourish, just as Initiative, a state-wide program for lung molecular regulation of the innate humans need this vitamin to metabolise cancer research to be led by Professor immune response. This early immune proteins and maintain a healthy Neil Watkins from the Centre for Cancer response determines how the body immune system. Dr Ferrero’s research Research. An Australian first, this state- responds to infection by pathogens. showed that preventing H. pylori cells wide integrated program will tackle lung Research groups focus on cytokine from producing vitamin B6 caused cancer through scientific collaboration signalling; gastrointestinal infection and the flagella – the ‘motors’ that drive across Victoria’s cancer centres. inflammation; Toll-like receptors; and the bacteria – to stop functioning. Professor Watkins will oversee projects the molecular regulation of immunity. This meant the bacteria could no longer in advanced tissue banking, data Professor Justin St John heads colonise and spread. This discovery management and outcome research, as the Centre for Reproduction and points to a potential therapeutic target well as focussed translational laboratory Development; a team that focuses for sufferers of peptic ulcers and some projects linked to early phase clinical on understanding how human forms of stomach cancers. trials. Professor Watkins also received a disease is propagated and transmitted. VCA Tumour Stream Grant of $500,000 The Centre’s research groups In a major research advance, Dr Paul to investigate innate chemoresistance focus on mitochondrial genetics; Verma has led a collaborative team in lung cancer. In addition, the VCA reprogramming of somatic stem cells; that has generated Australia’s first awarded Clinician Research Fellowships amnion stem cells; endocrinology and type 1 diabetes stem cells, providing to oncologists Drs Ben Markman and immunophysiology; and germ cell researchers with an ideal model for Elizabeth Sigston, from the Centre for development and epigenetics. understanding how type 1 diabetes Cancer Research. develops and progresses, and a tool for testing potential therapies. Dr Verma and his team created the cells using induced pluripotent stem (iPS) cell technology; a method of generating cells with stem cell-like properties.
96 Southern Health Research Report 2010 97 MONASH HEALTH TRANSLATION PRECINCT PARTNER REPORTS Monash Institute of Medical Research
Director of The Ritchie Centre, Professor Commercial A Phase III randomized study of Brivanib Euan Wallace, oversees a team of Alaninate (BMS-582664) in combination A phase Ib/II study of CYT997 in researchers that focus on stages of with Cetuximab (ERBITUX®) versus combination with carboplatin in human life from birth through infancy Placebo in combination with Cetuximab relapsed glioblastoma multiforme. and childhood. Ritchie Centre scientists (ERBITUX®) in patients with K-RAS Site Co-investigator (b) Jason Lickliter and clinicians have expertise in neonatal wild type tumours previously treated and fetal physiology, newborn intensive A multicenter, open-label phase 1b/2 with combination chemotherapy for care and paediatric sleep disorders. study to assess the safety and clinical metastatic colorectal carcinoma. Site The close collaboration between activity of intravenous combretastatin A1 Co-investigator (b) Ben Markman scientists of The Ritchie Centre, The diphosphate (OXi4503) as monotherapy A randomised phase II study Melbourne Children’s Sleep Unit and in subjects with primary or secondary evaluating weekly docetaxel, cisplatin, clinicians at the Monash Newborn hepatic tumor burden. Site fluoropyrimidine (wTCF) plus or minus Unit at Monash Medical Centre offers Co-investigator (b) Jason Lickliter a unique setting where research panitumumab in advanced oesophago- developments can be rapidly applied A phase Ib multiple ascending gastric cancer. Site Co-investigator (b) for the benefit of seriously ill babies dose study to evaluate the Ben Markman and children. The Ritchie Centre’s safety, pharmacokinetics and A Randomized Phase III Study of research groups focus on maternal- pharmacodynamics of BMS-833923 Weekly ABI-007 plus Gemcitabine fetal medicine; paediatric sleep; fetal (XL139) in combination with carboplatin versus Gemcitabine Alone in Patients and neonatal physiology; endometrial and etoposide followed by BMS-833923 with Metastatic Adenocarcinoma of the stem cells; placental stem cells; and alone in subjects with extensive-stage Pancreas. Site Co-investigator (b) Ben predicting pregnancy complications. small cell lung cancer. Site Co- Markman investigator (b) Jason Lickliter Solifenacin succinate in a flexible dose A Randomized, Multicenter, Open-Label WEBSITE regimen with simplified bladder training Phase 3 Study of Pemetrexed-Cisplatin versus solifenacin succinate in a flexible www.monashinstitute.org/ Chemotherapy Plus IMC-11F8 Versus parallel group, overactive bladder Pemetrexed-Cisplatin Chemotherapy symptom study. Site Chief investigator Alone in the First-Line Treatment of Centre for Women’s Health Research Patients With Nonsquamous Stage PUBLICATIONS, PATENTS, (CWHR) POSTGRADUATE STUDENTS IIIb or IV Non-Small Cell Lung Cancer AND FUNDING SUMMARY (NSCLC). Site Co-investigator (b) A prospective randomized placebo Ben Markman controlled double blind study into the Journal articles 159 effectiveness of Botulinum toxin A for A Randomized, Multicenter, interstitial cystitis. Site Chief investigator Open-Label, Phase 3 Study of Book chapters 9 CWHR Gemcitabine-Cisplatin Chemotherapy Conference presentations 126 Plus IMC-11F8 Versus Gemcitabine- Randomized controlled pilot study to (invited speakers) Cisplatin Chemotherapy Alone in the compare TVT and Monarc Suburethral First-Line Treatment of Patients With sling procedure in women with Patents 5 Squamous Stage IIIb or IV Non-Small urodynamic stress incontinence Cell Lung Cancer (NSCLC). Site Postgraduate research students 104 and Intrinsic Sphincter deficiency. Co-investigator (b) Ben Markman Site Co-investigator CWHR
Funding: A double blind placebo controlled A prospective randomized controlled randomized trial of PF-804 in patients study comparing vaginal prolapse Total number of competitive grants with incurable stage IIIB/IV non-small repair with and without Tensionfree awarded in 2010 = 118 cell lung cancer after failure of standard vaginal Tapr (TVT) in women with therapy for advanced or metastatic Research Project Grants = 70 severe genital prolapse and disease. Site Co-investigator (b) Ben (ARC = 6, NHMRC = 23) occult stress incontinence. Site Markman Co-investigator CWHR Equipment Grants = 7 Randomised comparative study Twin Birth Study. Site Chief investigator Fellowships = 17 (ARC = 1, of FOLFOX6m plus sir-spheres® CWHR NHMRC = 4) microspheres versus FOLFOX6m alone as first line treatment in patients with Scholarships = 4 (NHMRC = 2) non-resectable liver metastases from primary colorectal carcinoma. Site Travel Grants = 15 Co-investigator (b) Ben Markman Other = 5
96 Southern Health Research Report 2010 97 MONASH HEALTH TRANSLATION PRECINCT PARTNER REPORTS Monash Institute of Medical Research
MATCH: establishing an antenatally The effects of hospitalisation on sleep Novel approaches for assessing recruited cohort of twin. To recruit, on and children. Site Chief investigator cerebral circulation and oxygenation an ongoing and national basis, a large (a) Gillian Nixon in preterm human infants. Chief cohort of mothers and their twins as a Investigator Adrian Walker, Flora Wong resource for twin research in Australia, The impact of obstructive sleep apnoea to complement the Australian Twin on cardiovascular function; are children The impact of sleep disturbance on Registry’s current volunteer register with Down Syndrome at higher risk? daytime functioning, mood and quality of twins who are willing to consider Site Chief investigator (a) Gillian Nixon of life in children and adolexcents participating in approved studies. with cystic fibrosis. Chief Investigator Impact of sleep disorder breathing Site Chief investigator (a) Euan Wallace, Rosemary Horne on cardiovascular, behavioural and Joanne Mockler neurocognitive function in pre-school Effectiveness of treatment for the Epigenetic Twin Study. Epigenetic children. Site Chief investigator (a) resolution of the sequelae of sleep difference in twins: variability at birth, Rosemary Horne disordered breathing in children. effect of prenatal environment and Chief Investigator Rosemary Horne Defining sleep states using continuous postnatal divergence. Site Chief cerebral bedside monitors (aEEG) in Combination gefitinib and methotrexate investigator CWHR newborn infants. Site Chief investigator to treat ectopic pregnancies: phase I PROGRESS: Progesterone after (a) Rosemary Horne clinical trial. Chief Investigator Stephen previous preterm birth for the prevention Tong, Terry Johns, Euan Wallace Development of cardiovascular control of neonatal respiratory distress during sleep in human infants after Randomised double blind placebo syndrome. Site Chief investigator (a) preterm birth. Site Chief investigator (a) controlled trial on the effect of Euan Wallace, Joanne Mockler Rosemary Horne, Flora Wong intraperitoneal ropivacaine on PPROMT: Preterm, prelabour rupture postoperative pain and recovery Novel approach for assessing the of membranes close to term trial. Site after diagnostic laparascopy and development of cardiovascular Chief investigator (a) Euan Wallace, hysteroscopy. Site Chief investigator control after preterm birth. Site Chief Joanne Mockler Beverley Vollenhoven investigator (a) Rosemary Horne Syntocinon (oxytocin) bolus or XCEL bladeless trocar versus Veress Chronic Lung Disease in the Preterm Syntocinon bolus plus Syntocinon needle: a randomised controlled Neonate: Cytokine Profile Analysis. infusion at elective ceasarean section, trial comparing 2 entry techniques in Site Chief investigator (a) Alex Veldman a double-blind randomised controlled gynaecological laparoscopic surgery. Site Chief investigator Beverley trial. Site Chief investigator (a) Euan Duty ratio: a simple method for Vollenhoven Wallace, Joanne Mockler quantifying loop gain during breathing instability. Site Chief investigator (a) Hypoxia regulated mRNA measured in Assessment of ovarian reserve in Philip Berger maternal blood as a novel marker for premenopausal women with breast cancer following chemotherapy. intrapartum fetal distress. Site Co-chief Improving methods for treating Supported by The Victorian Cancer investigator CWHR breathing instability in patients with Agency. Site Chief investigator Beverley heart failure. Site Chief investigator What women want - Stem Cell Vollenhoven (a) Philip Berger, Garun Hamilton, Therapy for Mother and Baby. Ritchie Centre Site Chief investigator (a) Euan Wallace, Antenatal vitamin D study (AVID). Suppored by RANZCOG, Luke Joanne Mockler A multi-centre, open-label study Proposch Grant. Site Chief investigator of the safety, tolerability and Is vaginal birth after Caesarian Section Beverley Vollenhoven pharmacodynamics of intravenously being encouraged as safe for women? administered cPMP (Precursor Z) in Site Chief investigator (a) Euan Wallace, patients with Molybdenum CoFactor Joanne Mockler Deficiency Type A. cPMP01-08. Evaluation of Maternity Services at Chief Investigator (a) Alex Veldman, Casey Hospital. Site Chief investigator Flora Wong (a) Euan Wallace, Suzanne Sinni Novel use of Near Infrared The effect of premature birth on Spectroscopy to monitor the cerebral renal function in the neonate. haemodynamics and oxygenation Site Co-chief investigator Ritchie of infants with hypoxic ischaemic Centre (RC) encephalopathy. Chief Investigator Flora Wong
98 Southern Health Research Report 2010 99 MONASH HEALTH TRANSLATION PRECINCT PARTNER REPORTS REPORTS PARTNER PRECINCT TRANSLATION HEALTH MONASH MONASHResearch Medical HEALTHof Institute TRANSLATIONMonash PRECINCT PARTNER REPORTS
Prince Henry’s Institute
DIRECTOR: PROFESSOR MATTHEW GILLESPIE
Prince Henry’s Institute (PHI) was established in 1960 as a National Health and Medical Research Council accredited independent medical research institute established as a not-for-profit organisation at Southern Health’s Monash Medical Centre in Clayton, Melbourne.
RESEARCH ACTIVITIES RESEARCH HIGHLIGHTS WEBSITE
Research at PHI encompasses the DURING 2010 www.princehenrys.org full spectrum of translational research Discovering previously unknown from fundamental laboratory research proteins in the uterus, which may understanding human biology, through improve IVF success rates. PUBLICATIONS, AWARDS, studies focused upon developing better POSTGRADUATE STUDENTS diagnostics and new treatments, and Identifying possible new drugs and finally to clinical programs improving proteins which inhibit the spread of AND FUNDING SUMMARY patient care. Our focus is on reproductive breast cancer cells. Journal articles 85 science and health, and particularly the
hormones that are critically involved in Developing new markers of male Book chapters 4 reproduction and their capacity to influence fertility and sperm development. other complications or syndromes. Many Postgraduate research students 35 Identifying that mammary stem cells of the reproductive hormones impact upon (plus 14 honours students) are regulated by steroid hormones. the development of cancer, diabetes, obesity, cardiovascular disease, bone Determining mechanisms to promote health and human genetics. bone formation and limit bone loss.
The institute celebrated its 50th anniversary Linking immune function with high in 2010, and held a research day to blood pressure and heart disease. highlight its achievements in research and health care delivery. Uncovering biological mechanisms which link stress regulators with breast The institute’s funding is derived from cancer and bone formation. competitive international and national government grants, charitable trusts Determining factors that regulate sex and foundations, the corporate sector, determination. private philanthropy.
98 Southern Health Research Report 2010 99 MONASH HEALTH TRANSLATION PRECINCT PARTNER REPORTS Prince Henry’s Institute
Funding: Bayer Schering Pharma AG
Bill and Melinda Gates Foundation
Cancer Council Victoria
CASS Foundation
CONRAD
Department of Human Services, Vic
Harold and Cora Brennan Benevolent Trust
Harold Mitchell Foundation
Heart Foundation
Helen Macpherson Smith Trust
The Lalor Foundation Inc.
The Marion & E.H. Flack Trust
Medical Advances Without Animals
Monash IVF
National Breast Cancer Foundation
NHMRC: Program Grants, Project Grants, Fellowships, Scholarships and infrastructure
National Heart Foundation
National Institutes of Health (USA)
Ovarian Cancer Research Foundation
Clive and Vera Ramaciotti Foundation
The Trust Company
USA Department of Defense
University of California Los Angeles
Victorian Cancer Agency
Victorian Government’s Operational Infrastructure Support Program
Other commercial contracts
100 Southern Health Research Report 2010 101 MONASH HEALTH TRANSLATION PRECINCT PARTNER REPORTS REPORTS PARTNER PRECINCT TRANSLATION HEALTH MONASH MONASHInstitute Henry’s HEALTHPrince TRANSLATION PRECINCT PARTNER REPORTS
Southern Clinical School Faculty of Medicine, Nursing and Health Sciences, Monash University
DIRECTOR: PROFESSOR STEPHEN HOLDSWORTH
The Southern Clinical School (SCS) of Monash University is the largest clinical single site for medical undergraduate teaching.
Monash Medical Centre provides over The acquisition of two key PUBLICATIONS, 70% of our interns. Most of the academic national research leaders POSTGRADUATE STUDENTS staff of the school are actively engaged Professor Mandy Thrift and Assoc. in research. The school is also the Professor Dominique Cadhilac have AND FUNDING SUMMARY academic organisation through which enhanced critical mass and national Journal articles 168 most of the adult physicians and surgeons recognition of the Centre for Stroke and of Southern Health do their research as Ageing in the Southern Clinical School. Books 1 will be seen from our publication list. Book chapters 3 There are many research groups in the Publication outputs totalling 173 school and three designated Monash Publications in prestigious journals Postgraduate research students 46 University Research Centres: Centre for including BMJ, New England Journal Inflammatory Diseases (Director, Professor of Medicine, Lancet, JASN, Journal of Funding: Stephen Holdsworth), Monash Cardiology Immunology, Arthritis & Rheumatism, Research Centre (Director, Professor Hepatology, Neurology and Brain. Competitive Jim Cameron) and Centre for Stroke and Ageing (Director, Associate Professor RACS, Scholarship. RACS Foundation Velandai Srikanth). Most of the physicians RESEARCH ACTIVITY for Surgery Scholarship. Chen, Y. 2010: and surgeons at Southern Health have $37,372. 2009-2010: $57,500 (Monash Most of the researchers in the departments Monash University appointments within University). of the SCS have Southern Health clinical the Southern Clinical School. service roles in the many clinical units of NHMRC Biomedical PG Research the hospital. Similarly most of the adult Scholarship. Chen, Y. 2010: $35,750. RESEARCH ACHIEVEMENTS physicians and surgeons at Southern 2010-2011: $48,942 (Monash Health have SCS academic appointments. University). IN 2010 For the purposes of this report, it has NHMRC Principal Research Fellow. been agreed that their projects and Tipping, P. 2010: $138,074. 2007-2010: NHMRC competitive grant achievements be listed under their $521,000 (Monash University). success in 2010 designated units. The Southern Clinical SCS academics (Monash Uni/ School comprises the Departments of: NHMRC, Program Grant. Innovative Southern Health clinical scientists) were Medicine, Surgery, Paediatrics, Obstetrics stem cell-based strategies to establish successful in obtaining nine research & Gynaecology and Nutrition & Dietetics immune tolerance & tissue repair. grants (with eight as CIA, one as CIB) Toh, B-H. 2010: $305,033. 2007-2011: worth a total of $4,853,353.92. $1,427,168 (Monash University). WEBSITE NHMRC, Project Grant. MIF regulation www.med.monash.edu.au/scs/ of MKP-1 & glucocorticoid responses in RA. Morand, E. 2010: $135,347. 2008- 2010: $398,157 (Monash University).
100 Southern Health Research Report 2010 101 MONASH HEALTH TRANSLATION PRECINCT PARTNER REPORTS Southern Clinical School
NHMRC Principal Research Fellow. Australia CTR HIV & Hepatitis Virology NHF, Project Grant. Sequential NKT Hickey, M. 2010: $114,128. 2008-2012: Research, Contract Research. Using and NK activation and regulatory T $565,880 (Monash University). toll like receptors to predict treatment cell suppression in atherosclerosis. responses in HIV positive patients Toh, B-H. 2010: $64,500. 2010 -2011: NHMRC PG scholarship. Summers, coinfected with hepatitis C or hepatitis $129,000 (Monash University). S. 2010: $17,924. 2008-2010: $82,555 B. Visvanathan, K. 2010: $40,000. 2009- (Monash University). 2010: $120,000 (Monash University). NHF, Project Grant. Regulation of leukocyte chemokine responses by Genzyme Corp, Int Research. Arthritis Research Phd scholarship. MIF. Hickey, M. 2010: $64,500. 2010 – Mechanisms of leukocyte activation Morand, E / Gui, R. 2010: $12,021. 2011: $129,000 (Monash University). & adherence in glomeruli in ANCA- 2009-2011: $79,777 (Monash associated glomerulonephritis in vivo. University). RACP, JRE Award. The role of mast cells Kitching, A. 2010: $51,632. 2008-2010: in progressive renal injury. Summers, S. $168,176 (Monash University). NHMRC (shared), Project Grant. 2010: $90,000 (Monash University). Pharmacological effects of oral NHMRC, Project Grant. Suppression L-citrulline and tetrahydrobiopterin in Cortical P/L, Contract Research. of immune tole-like receptor (TLC) patients with peripheral artery disease. Macrophage migration inhibitory factor signalling by Hepatitis B e Antigen McGrath, B. 2010: $64,033. 2009-2010: (MIF) in human and animal health. (HBeAg). Visvanathan, K. 2010: $128,066 (Monash University). Morand, E. 2010: $156,250 $81,000. 2008-2010: $243,333 (Monash University). (Monash University). NHF, Project Grant. Effect of ambulance based diagnosis on heart attack NHMRC (shared), Program Grant. NHMRC, Project Grant. A population outcome. Cameron, J. 2010: $57,675. Vascular Biology. Hickey, M. 2010: based cohort study of brain ageing 2009-2010: $115,350 (Monash $299,433. 2010-2011: $598,866 –rates of brain structural change, University). (University NSW). functional effects and mechanisms. Srikanth, V. 2010: $15,421. 2008-2012: NHMRC, Research Fellowship B Asthma Foundation VIC, Award. $148,800 (Monash University). (SRFB). Nikolic Paterson, D. 2010: Investigating the mechanisms of $126,101. 2009-2013: $618,750 innate immunity suppression by NHMRC, Project Grant. The role of the (Monash University). TGF-beta. Thomas, B. 2010: $20,000 cytoplasmic domain of tissue factor in (Monash University). maintenance of the glomerular filtration NHMRC, Project Grant. Mechanisms barrier. Tipping, P. 2010: $162,402. of glomercular leukocyte recruitment. NHMRC, Project Grant. Role of human 2009-2011: $460,000 (Monash Hickey, M. 2010: $192,080. 2010-2012: amnion epithelial cells in resolving University). $565,500 (Monash University). hepatic fibrosis. Sievert, W. 2010: $65,000. 2010-2012: $195,000 NHMRC (shared), Project Grant. NHMRC, Project Grant. Mechanisms (Monash University/MIMR). Role of tetraspanins in integrin function of disease in humans with MPO- and leukocyte migration. Hickey, M. ANCA associated glomerunephritis. NHMRC, Project Grant. Development 2010: $69,890. 2009-2011: $201,375 Holdsworth, S. 2010: $174,757. 2010- of a signature for early response (Monash University). 2012: $514,500 (Monash University). to influenza strains that determine/ correlate with severity for infection, NHMRC (shared), Project Grant. NHMRC, Project Grant. vaccine response and changes in The role of renal dendritic cells Immunoregulation in the pathogenesis virulence. Visvanathan, K. 2010: in infection and immunity under and therapy of autoimmune anti $70,000 (Monash University/MIMR). immunosuppression. Kitching, A. myeloperoxidase glomerulonephritis. 2010: $79,214. 2009-2011: $228, Holdsworth, S. 2010: $92,983. 2010- CBio LTD, Contract Research. X-toll 126 (Adelaide University). 2012: $273,750 (Monash University). in artheroscierosis. Toh, B-H. 2010: $114,658 (Monash University). Arthritis Australia PG Scholarship. NHMRC, Project Grant. The role of Morand, E / Ngo, D. 2010: $15,000. myeloperoxidase in adaptive immunity NHMRC, Sub Agreement. Establishing 2009-2010: $35,000 (Monash and the development of experimental a rapid alert system for severe University). glomerulonephritis and arthritis. respiratory illness in adults: The fluCAN Odobasic, D. 2010: $174,757. 2010- surveillance system. Visvanathan, K / DIISR ISL French/Australia. Expression 2012: $514,500 (Monash University). Korman T. 2010: $50,000 (Australian and function of glucocorticoid induced National University). leucine zipper in rheumatoid arthritis. Arthritis Australia, Project Grant. Morand, E. 2010: $5,500. 2009-2010: GILZ function in endothelial cell NHMRC, CDA. Cerebrovascular $22,050 (Monash University). biology. Morand, E. 2010: $30,000 diseases in ageing populations. (Monash University). Srikanth, V. 2010: $96,040. 2010-2013: $384,160 (Monash University).
102 Southern Health Research Report 2010 103 MONASH HEALTH TRANSLATION PRECINCT PARTNER REPORTS Southern Clinical School
NHMRC, Project Grant. Type 2 Kathleen Tinsley Trust, Fellowship. diabetes mellitus and cognitive Novel approaches to bedside decline – a longitudinal study of monitoring of cerebral oxygenation effects and mechanisms. Srikanth, in infants with HIE undergoing V. 2010: $99,595. 2010-2014: therapeutic hypothermia. Wong, $463,875 (Monash University). F. 2010: $60,000. 2010-2011: $135,000 (Monash University). US NIH, Contract Research. Collaborative GWAS of dementia, Dietitians Association Australia, AD and related MRI and cognitive Research Project. Systematic endophenotypes. Srikanth, V. 2010: literature review to update the $35,339. 2010-2012: $42,000 Dietary Guidelines. Truby, H. 2010: (Monash University). $31,182 (Monash University).
NHMRC biomedical PG research Butterfly Foundation, Research scholarship. Sanders, L. 2010: Project. Evaluating the efficacy of $35,750. 2010-2012: $107,750 the school based program ‘Girls (Monash University). on the Go’ to improve self esteem, body satisfaction and physical NHF-NHMRC CDA. Cerebrovascular activity in a multi-cultural environment disease and dementia. Srikanth, V. (a randomized controlled trial). 2010: $30,000 (Monash University). Truby, H. 2010: $100,000. 2010-2011: $200,000 (Monash University). Merck Serono Australia, Contract Research. The role of T lymphocyte subsets in the evolution and functional outcome of ischaemic stroke. Sanders, L. 2010: $49,850 (Monash University).
RACP, Fellowship. Evaluation of myocardial delayed contrast enhancement by 320-slice cardiac computed tomography for the prediction of myocardial viability prior to coronary revascularisation. Dundon, B. 2010: $74,500 (Monash University).
NHMRC, JC Martin Fellowship. The cellular origin and nuclear signaling mechanisms of cardiac stem cells. White, A. 2010: $40,004. 2010- 2011: $120,012 (Monash University).
NHMRC, Project Grant. Selective targeting of acute renal injury by inhibition of the receptor tyrosine kinase, c-fms. Nikolic Paterson, D. 2010: $145,104. 2010-2012: $427,200 (Monash University).
NHMRC Project Shared. Resolvin E1 is a novel anti-inflammatory and anti-fibrotic lipid mediator for the treatment of chronic kidney disease. Nikolic Paterson, D. 2010: $22,469. 2010 2012: $99,850 (Monash University).
102 Southern Health Research Report 2010 103 COLLABORATIONS
BioGrid Australia
CHIEF EXECUTIVE OFFICER: MR BOB ATWILL
CLINICAL DIRECTOR: ASSOCIATE PROFESSOR PETER GIBBS
SOUTHERN HEALTH REPRESENTATIVE: MS MALAR THIAGARAJAN, DIRECTOR OF RESEARCH SERVICES
Our Vision – integrating health and research data to facilitate improved health outcomes. BioGrid Australia is a secure research platform and infrastructure that provides access to real-time clinical imaging and biospecimen data across institutions, jurisdictions and diseases.
The web-based platform provides ethical Data currently linked to BioGrid is in excess on bowel cancer treatment decision access while protecting both privacy of 195,000 privacy-protected patients for making and building on the already and intellectual property. 2010, across 10 tumour stream areas established data collection and analysis and life sciences including cystic fibrosis, resources of BioGrid in this tumour The web-based platform has the capacity diabetes and neurosciences with ongoing stream, collecting data on up to 1,000 to uniquely identify and ethically integrate expansion of the network of data. patients across Australia. Using BioGrid data collected about a consumer across technology, the project will provide multiple institutions. BioGrid also has the insight into how clinicians choose from capability to link data with other datasets, RESEARCH HIGHLIGHTS the multiple potential treatment options produce tailored reports for audit and IN 2010 available for patients with advanced presentation purposes and provide bowel cancer. statistical analysis tools to conduct more Roche project: advanced research analysis. Authorised This significant study between BioGrid users can access, transform and add to and Roche Products continued to data and test research questions using progress in 2010. The study focuses their own analytical tools or those made available by BioGrid.
104 Southern Health Research Report 2010 105 COLLABORATIONS BioGrid Australia
Launch of CART-WHEEL.org: RESEARCH ACTIVITIES Professor Sir Gustav Nossal launched CART-WHEEL.org (Center for Analysis Southern Health Breast Services of Rare Tumours) on 14 April 2010. involved in the development of the Funded by the Victorian Cancer Agency ACCORD breast module. They have this consumer grant has enabled a been the testing the online test world-first website to be developed database and providing feedback. providing an ethically approved web Clinician involved: Dr Jane Fox portal for consumer driven research into rare tumours and molecular sub-types Colorectal data is currently being of common tumours. collected on paper forms. The IT department has approved the New ACCORD modules: application for installation and the There has been significant development next step will be the installation of during the past 12 months with the the ACCORD database. Clinician completion of multiple new ACCORD involved: Prof Bruce Waxman. (Australian Comprehensive Cancer and Research Database) modules namely; Interest in the chemotherapy breast, prostate and renal cancer, and prescribing module of ACCORD which chronic lymphocytic leukaemia. Due to will be ready in 2011. Clinician involved: clinician interest, the software has been Dr. Peter Briggs. installed at many new institutions with Lung Project: data collection across many new sites. The lung cancer project funded by Clinical Viewer Project: Victorian Cancer Agency aims to make Development of a web-based portal it easy for researchers to access data (Clinical Viewer), which allows and tissue for lung cancer research. authorised clinicians treating the same The project involved collection of tissue patient for the same disease across a from biopsy and surgery, collection number of sites and medical disciplines, of clinical and treatment data and the to view relevant identified patient establishment of a lung cancer registry. information from outside an institution. This data will all be made available This project was made possible by the through BioGrid for researchers to utilise support of the Western and Central and an over-arching ethics approval Melbourne Integrated Cancer Service. for clinical, laboratory and population health projects will be submitted across participating sites.
104 Southern Health Research Report 2010 105 RESEARCH GROUP REPORTS
Victorian Cancer Biobank
SOUTHERN HEALTH CONSORTIUM REPRESENTATIVE: DR BEENA KUMAR
The Biobank at Southern Health is one of the four consortium members of Victorian Cancer Biobank.
The BioBank supports various translational RESEARCH ACTIVITIES Current projects cancer research studies by providing good Evaluation of immunohistochemical quality fresh / fixed tissue from various The SH node of the Biobank has provided markers to predict tumour response to cancers and the associated serum and comprehensive research material to neoadjuvant chemotherapy in breast blood samples. The major development support the following projects: Ovarian cancer. Vinod Ganju, Beena Kumar, in 2010 has been in supporting project cancer study (Healthlinx) with Dr Dominic Peter Midolo, Jane Fox, Leonie Cann, specific sample collection eg, thyroid Auellilo; Glioma study with Dr Terry Johns Zdenka Prodanovic, Alexandra De cancer studies and the glioma study for as principal researcher; and colorectal Gusclin, John Stuckey, Peter Rogers, researchers within Southern Health and cancer study (Dr Oliver Sieber, Ludwig Stewart Hart. Project ongoing. Monash Institute of Medical Research. Cancer research Institute). Detection of a stem cell population The Biobank has excellent storage Poster presentation at the Research week in excision specimens from breast facilities for optimal preservation of at Southern Health (Multidisciplinary cancer patients after neoadjuvant tissue and blood samples, a well updated support in specimen collection and chemotherapy. Vinod Ganju, Beena easily accessible patient database and a processing, May 2010) and Australian Kumar, Peter Midolo, Jane Fox, state of the art Aperio digital scanner for Bionetworking Conference in Brisbane Neil Watkins, Leonie Cann, Zdenka image storage and analysis. The scientific (Thyroid research study- direct support by Prodanovic, Alexandra De Gusclin, staff are well trained in blood processing, Southern Health, December 2010). sample collection, tissue processing and Stewart Hart. Project ongoing. other techniques like creation of Tissue Micro Arrays. The staff members are Completed projects strongly encouraged to involve themselves Evaluation of Lymphatics in the Human PUBLICATIONS AND in research projects and generate posters Placental Bed and Surrounding the FUNDING SUMMARY and publications. Spiral Arterioles in Decidualised Journal articles 1 Endometrium. Mila Volchek, Jane Girling, Gendie Lash, Leonie Cann, Conference presentations 5 Beena Kumar, Stephen Robson, Judith Bulmer, Peter Rogers. Project completed. Results published. Funding:
A dermatopathological scoring Competitive system to quantify acute synchrotron Cancer Council Victoria, Project grant. microbeam and broad beam radiation Victorian Cancer Research. Dr Beena damage to normal mouse skin. Priya Kumar. 2010: $457,250. 2007-2012: Capuge, Jeffrey Crosbie, Beena Kumar, 2.2 Million (Southern Health). Peter Rogers. Project completed. Results accepted for publication.
106 Southern Health Research Report 2010 107 POSTGRADUATE STUDENTS
DOCTOR OF PHILOSOPHY Cody Allison Pratiti Bandopadhayay (PHD) STUDENTS The role of the cytosolic pathogen The role of the EWS/WT1 fusion protein recognition molecule Nod1 in host in the development of tumours. responses to Helicobacter pylori infection. Latasha Abeynaike Anticipated completion: 2011 Anticipated completion: 2011 Mechanisms of lymphocyte recruitment University of Melbourne in dermal inflammation. Monash University Anticipated completion: 2014 Tamar Black Irene Apostolopoulos Monash University CBT vs ACT for prevention of youth Aeration of the lung at birth. depression. Abu Abraham Anticipated completion: 2013 Anticipated completion: 2014 Macrophage activation in kidney Monash University Monash University disease and renal transplant rejection. Anticipated completion: 2011 Maryam Pashai Asl Genia Burchall Monash University Generation of embryonic stem cell lines Haemostatic system in polycystic from IVF embryos and parthenotes. ovarian syndrome. Sarah Abrahamson Completed: 2010 Anticipated completion: 2013 Sensory Processing in Autism Monash University RMIT Spectrum Disorders. Anticipated completion: 2013 Ana Baburamani Michele Callisaya Monash University The influence of prenatal events on Aging and Gait. the ability of newly-born lambs to Completed: 2010 resuscitate themselves. Dimuthu Alankarage University of Tasmania Anticipated completion: 2011 Novel genes in sex determination Monash University Monash University
106 Southern Health Research Report 2010 107 POSTGRADUATE STUDENTS
Edmund Carvalho Jennifer Conrick Matthew Damasiewicz In-situ gelling nanoparticulate systems for PhD Vitamin D and chronic kidney disease: tissue engineering using stem cells. Allied Health effects on mineral metabolism, vascular Anticipated completion: 2013 calcification and transplant outcomes. Indian Institute of Technology, Bombay and Sanja Coso Anticipated completion: 2012 Monash University Molecular mechanisms controlling Monash University lymphatic endothelial cell motility in Samantha Cassar prostate cancer lymph node metastasis. Zoe Davidson The role of mitochondria and exercise in Anticipated completion: 2012 Advancing dietetic practice in Duchenne women’s health. Monash University muscular dystrophy. Anticipated completion: 2013 Anticipated completion: 2012 Victoria University Davina Cossigny Monash University The role of TGF-b superfamily Ally Chau members: TGF-b1 and activin A in Annette Davis early folliculogenesis. Interactions between breast cancer cells The effect of footwear on falls and gait and the bone micro environment. Monash University characteristics amongst older adults Monash University Anticipated completion: 2014 Rebecca Craythorn Monash University Justin Chen The role of the follistatin isoforms in the female reproductive tract. The role of TGF-b ligands in muscle Sapna Devi Anticipated completion: 2010 wasting and cachexia. Mechanisms of glomerular leukocyte Monash University Monash University trafficking. Anticipated completion: 2012 Davina Crossigny (nee Rosairo) Yi Chen Monash University Functional significance of activin A in Regulation of ovarian follicle development. cardiopulmonary bypass and myocardial Anticipated completion: 2011 Yu (Carol) Dou ischemia reperfusion injury. Monash University Role of the IFN-induced helicase-1(IFIH1) Monash University in Type 1 Diabetes. Peng Cui Anticipated completion: 2013 Vanessa Cheung The roles of b cell in experimental Monash University Role of PTHrP in DNA repair and cellular autoimmune encephalomyelitis apoptosis of cancer cells. pathogenesis. Damien Eeles Monash University Anticipated completion: 2014 The roles of IL-33 and galanin in bone. Monash University La Trobe University Jenny Chow The role of estrogen in triglyceride Anna Cvrljevic Stacey Ellery homeostasis. Activation of Src family kinases in Birth asphyxia and acute renal failure: the Completed: 2010 human derived glioma cell lines protective capacity of maternal dietary induces mitochondrial localisation of Monash University supplements. the De2-7 EGFR. Anticipated completion: 2014 Tracy Comans Completed: 2010 Monash University Domiciliary vs centre-based therapy for Monash University geriatric rehabilitation. Samuel Forster Completed: 2010 Daniel Czech Biological and computational annotation of Investigating the role of SRY in University of Queensland the type 1 interferon signalling pathway. dopamine regulation and gender bias in neurological pathology. Anticipated completion: 2014 Paul Conforti Monash University Monash University Chararcterisation of Type 1 and Type 2 interferons of the black flying fox, Pteropus Alecto. Anticipated completion: 2013 Monash University
108 Southern Health Research Report 2010 109 POSTGRADUATE STUDENTS
Nerellie Freeman Cynthia Gonzalez Cheryce Harrison Development of a new attention scale to Effects of growth promoters and inhibitors Lifestyle interventions in insulin resistance assess inattentive behaviours, cognitive on fibrobiast activity in normal, keloid and related conditions. attention and working memory across Dupuytren’s disease tissues: developing Anticipated completion: 2011 neurodevelopmental disorders. strategies for improving treatment options. Monash University Anticipated completion: 2014 Anticipated completion: 2013 Monash University Monash University Penelope Hartmann Early cognitive and behavioural outcomes Lulu Fu Annette Graham following prenatal exposure to antiepileptic Fibroblast activation and endometriosis. Bibliotherapy, its current and potential drugs (AEDs). Anticipated completion: 2011 useage by Australians with mental Anticipated completion: 2012 health problems. Monash University Monash University Anticipated completion: 2013 Ka Yee Fung Monash University Jenna Haverfield Characterization of the novel type I Hormonal regulation of Sertoli cell IFN - Ifn-epsilon. Claire Greenhill function in vivo. Anticipated completion: 2011 The role of STATS in inflammation. Monash University Monash University Anticipated completion: 2011 Monash University Corey Heffernan Robert Galinsky Generation of embryonic stem Effect of intrauterine inflammation on Alexandra Grubman cell-like cells from reprogramming renal development, cardiopulmonary Identification and characterization of novel somatic cell nuclei. and cerebral haemodynamics. colonization factors of Helicobacter pylori. Anticipated completion: 2011 Anticipated completion: 2013 Anticipated completion: 2012 Monash University Monash University Monash University Amy Herlihy Brook Galna Ran Gu The effect of diagnosis and intervention The biomechanics of obstacle crossing The role of macrophage migration on the psychological impact of in people with Parkinson’s disease. inhibitory factor (MIF) in osteoclastogenesis Klinefelter’s syndrome. Completed: 2010 and bone erosion. Anticipated completion: 2011 University of Melbourne Anticipated completion: 2013 Monash University Monash University Poh-Yi Gan Anne-Marie Hill Effector mechanisms of glomerular injury Priyanka Gupta Application of the health-belief model to in models of autoimmune anti-MPO Modelling, design and optimisation of understanding falls and uptake of falls induced glomerulonephritis. novel stem cell bioreactors. prevention interventions. Anticipated completion: 2011 Anticipated completion: 2012 Completed: 2010 Monash University Indian Institute of Technology, Bombay and University of Queensland Monash University Esther Ginsberg Hui Ting Ho Ocular motor functioning in adults with Sabrina Gupta Proprotein convertase 6: role in embryo autism and Fragile X Syndrome. Ethnicity, cardiovascular disease and implantation and clinical implications. Anticipated completion: 2013 diabetes: A comparison between South Monash University Asians and Anglo Australians in Melbourne. Monash University Anticipated completion: 2011 Rebecca Jane Hobbs Tony Goldschlager Monash University Transforming growth factor-β superfamily members and primordial follicle activation The role of progenitor stem cells in in the immature mouse ovary. promoting cervical interbody fusion. Completed: 2010 Completed: 2010 Monash University Monash University
108 Southern Health Research Report 2010 109 POSTGRADUATE STUDENTS
Ryan Hodges Adam Hutchison Beth Johnson Human amnion cells as a therapy for Approaches to optimising outcome Do autism and Asperger’s disorder have preterm lung disease. in ST-elevation and non-ST elevation different neurobiological underpinnings: Anticipated completion: 2011 myocardial infarction. An Ocular motor and handwriting study. Monash University Anticipated completion: 2013 Anticipated completion: 2012 Monash University Monash University Alberta Hoi The role of macrophage migration Samantha Hutchison Zane Kaplan inhibitory factor in the pathogenesis Role of exercise in treatment of women The impact of glycoprotein-IB of systemic lupus erythematosus. with PCOS: mechanisms of action. binding to thrombin on platelet and Completed: 2010 Anticipated completion: 2011 neutrophil interaction. Monash University Monash University Anticipated completion: 2014 Monash University Darcy Holt Melanie Hutton Monash University The role of cholesterol in H. pylori Joshua Kausman interactions with the host. The role of dendritic cells in pathological Finbar Hopkins Anticipated completion: 2012 immune responses in the kidney. Self as parent: developing the Monash University Anticipated completion: 2011 supportive figure. Monash University Anticipated completion: 2012 Liane Loannou Monash University Reproductive genetic screening: Kelly Kenna Attitudes and outcomes. Ethanol-induced fetal brain injury and Louis Huang Anticipated completion: 2013 fatty acid ethyl esters in meconium: studies in pregnant sheep. Cell type specific mechanisms of Monash University mineralocorticoid-mediated renal Anticipated completion: 2010 injury in glomerulonephritis and Alicia James Monash University diabetic nephropathy. Heel raises versus prefabricated Anticipated completion: 2013 orthoses in the treatment of posterior Lauren Kerr Monash University heel pain associated with calcaneal Paediatric brain cancers. apophysitis (Sever’s Disease): a Anticipated completion: 2013 randomised control trial. Sonya Hubbard Monash University Cell surface markers for identifying Anticipated completion: 2015 endometrial cancer stem cells. Monash University Renee Kharsas Completed: 2010 Spouses of aged care residents: Monash University Stacey Jamieson promoting wellbeing through Molecular pathogenesis of granulosa support groups. Maureen Humphrey cell tumours. Anticipated completion: 2012 Energy and protein requirements and Completed 2010 Monash University tolerance in children with inborn errors Monash University of metabolism. Jing Jing Khoo Anticipated completion: 2018 Jenika Jjayamaha The role of mitochondrial ubiquitin ligase Monash University Cardiovascular consequences of sleep 1 (Mul1) in the initiation of inflammation apnoea: Derangement of coagulation. and apoptosis in response to viral invasion. Sonay Hussein-Fikret Anticipated completion: 2014 Anticipated completion: 2012 Steroid receptor coactivators in ovarian Monash University Monash University granulosa cell tumours. Monash University Anju Joham Obesity, insulin resistance and polycystic ovarian syndrome. Anticipated completion: 2013 Monash University
110 Southern Health Research Report 2010 111 POSTGRADUATE STUDENTS
Marlene Klaic Emily Yan Mei Lam Kevin Tuan-An Luu Enhancing uptake of evidence Differential regulation of the Investigating the Interaction Between based practice amongst allied health mineralocorticoid receptor by TRAF6, STAT1 and STAT3. professionals. corticosteroids and high salt in Anticipated completion: 2013 cardiovascular disease. Anticipated completion: 2012 Monash University Monash University Completed: 2010 Monash University Carissa Lyons Virginia Knight Predictors of school-age children’s The role of coagulation factors and Tali Lang occupational performance. their receptors in the pathogenesis of Immunomodulation of TLR signaling Anticipated completion: 2014 hepatic fibrosis. by Hepatitis B Virus. Monash University Anticipated completion: 2011 Anticipated completion: 2011 Monash University Monash University Annie McDougall Fetal and neonatal lung physiology. Brian Ko Kyren Lazarus Anticipated completion: 2011 Pathophysiological aspects of Role of LRH-1 in breast cancer. Monash University ventricular vascular interaction and Monash University myocardial perfusion. Lisa McKenzie Anticipated completion: 2013 Qian Li Developmental and signalling pathways Monash University Targeting IL-13Ralpha2 in glioma with in brain tumours. a monoclonal antibody. Anticipated completion: 2014 Anton Kolosov Anticipated completion: 2011 Monash University Preclinical investigation of novel Monash University putative analgesics in combination. Steven McPhail Anticipated completion: 2012 Rui Liang Measurement of health-related quality Monash University Gut regeneration. of life amongst older adults Completed: 2010 Completed: 2010 Savvas Kondouros Chong Qing Medical University University of Queensland Improvement of the current culture in human embryonic stem cells. Jason Liew Jovana Maksimovic Anticipated completion: 2012 The role of estrogen in ovarian function. Comparative genomics of lactation. Monash University Monash University Anticipated completion: 2011
Anna Kourbasis Monash University Andy Lim Effectiveness of treatment for the Novel anti-inflammatory strategies for resolution of the sequelae of sleep Katrina Malin treating diabetic nephropathy. disordered breathing in children. The influence of personality and trauma Completed: 2010 Anticipated completion: 2012 on individuals who suffer fibromyalgia. Monash University Monash University Anticipated completion: 2012 Monash University Yu-Han Liu Claudine Kraan Immune-modulation of different Characterising the neuromotor profile Cara Mand mesenchymal and placental stem cells of FMR1 premutation carriers: A search Predictive genetic testing in adolescents on a mouse model of multiple sclerosis. for presymptomatic markers of FXTAS for adult-onset genetic conditions. Anticipated completion: 2013 in men and women. Anticipated completion: 2012 Monash University Anticipated completion: 2014 Monash University Monash University Izelle Llubuschange Monash University
110 Southern Health Research Report 2010 111 POSTGRADUATE STUDENTS
Catherine Martin Chris Moran Hong Nguyen Characterisation of isolated clinic Diabetes and dementia. Identifying stem/progenitor cells in hypertension by functional and Anticipated completion: 2014 normal and malignant endometrium. circulation biomarkers. Monash University Anticipated completion: 2012 Anticipated completion: 2012 Monash University Monash University Melissa Mulraney Irritability in adolescents. Peter Nicholls Tamara May Anticipated completion: 2014 Mechanisms of spermiation failure. Anxiety and academic functioning Monash University Monash University in males and females with autism spectrum disorder. Sean Murphy Lauren Nisbet Kids Focus study: How inattention Impact of sleep disordered breathing and anxiety impact on academic Placental stem cells as a treatment for on cardiovascular function in preschool performance in children. lung disease. children. MBBS/PhD Anticipated completion: 2014 Anticipated completion: 2011 Anticipated completion: 2014 Monash University Monash University Monash University
Robert Meek Belinda Murray Niroj Obeyesekere The paramedic collaboration with triage Stem Cell Lines in sheep - isolation, TAK1 signalling in macrophage-mediated (PACT) study. Aiming to improve patient culture & characterisation. kidney disease. safety at the ambulance- ED interface. Anticipated completion: 2011 Anticipated completion: 2011 Anticipated completion: 2017 Monash University Monash University Monash University Shyamala Nadathur Bree O’Connell Jacqueline Melville The influence of hospital IT infrastructure Placentation, and the maintenance Prenatal inflammation & glucorticoids on surgery waiting list and ambulance of pregnancy in the spiny mouse influence immune function. bypass. (/Acomys cahirinus/). Anticipated completion: 2014 Completed: 2010 Anticipated completion: 2013 Monash University Monash University Monash University
Sirisha Mendis Ziad Nehme Luis Malaver Ortega Activin and its role in the developing Early indicators of cardiac arrest in Are adult mesenchymal stem cells a fetal testis. patients in the pre-hospital setting more successful target to generate Anticipated completion: 2014 Completed: 2010 induced pluripotency stem cells? Monash University Monash University Anticipated completion: 2014 Monash University Alistair Miller Peter New A study of patient flow through Aging and assessment of emphysema Joan Ostaszkiewicz in GP130 mutant mice. inpatient rehabilitation and potential for improvements Providing continence care in Anticipated completion: 2013 residential aged care settings: Anticipated completion: 2015 Monash University A grounded theory study. Monash University Anticipated completion: 2012 Michael Mond Deakin University Devi Ngo Defining the molecular pathogenesis of The expression and function of thyroid tumours. Kim O’Sullivan glucocorticoid-induced leucine zipper Anticipated completion: 2012 in models of rheumatoid arthritis. Characterisation of Th 17 immune Monash University responses in anti-neutrophil cytoplasmic Anticipated completion: 2012 antibody Glomerulonephritis. Monash University Anticipated completion: 2017 Monash University
112 Southern Health Research Report 2010 113 POSTGRADUATE STUDENTS
Claire Palermo Amanda Purcell Jennifer Re An evaluation of a mentoring Cancer-related fatigue amongst people The heart of the matter: the developing intervention for public health nutrition undergoing radiation therapy. mother-infant relationship in prenatal workforce development. Completed: 2010 and postnatal diagnosis of congenital heart disease. Completed: 2010 University of Queensland Monash University Completed: 2010 Renaud Pierre Quantin Monash University Kirsten Palmer Pax6 involvement in bladder cancer The development of therapeutics for metastasis. Jessica Ryan pre-eclampsia. Anticipated completion: 2013 Signalling pathways in antibody-mediated Anticipated completion: 2012 renal injury. Monash University Tracey Quinn Anticipated completion: 2012 Susceptibility of the fetal brain and Monash University Nicole Papadopoulos adrenal gland to maternal stress in a Neuromotor functioning in children precocial rodent. Georgina Ryland with autism and Fragile X Syndrome. Anticipated completion: 2013 Next generation sequencing of candidate Anticipated completion: 2012 Monash University ovarian tumor suppressor genes. Monash University Anticipated completion: 2013 Jyothsna Rao Monash University Irene Papageorgiou Effect of fat-derived hormone adiponectin The role of Cripto in tumourogenesis. on pancreatic beta cell function in Burcu Saglam Type 2 diabetes. Monash University The effects of sulfasalazine use on Completed: 2010 infection-mediated fetal brain injury. Rebecca Pellicano Monash University Completed: 2010 Effect of tight fluid control in dialysis Monash University patients on inflammation and Dilip Ratnam cardiovascular outcomes. Hepatitis B virus tolerance, clearance Nur Akmarina Mohd Said Completed: 2010 and the host immune response. Development of a high content screening Monash University Anticipated completion: 2011 assay to identify modulators of epithelial/ Monash University mesenchymal transition in cancer cells. Debbie Phyland Anticipated completion: 2013 Vocal fold oedema. Udani Ratnayake Monash University Anticipated completion: 2013 The effects of exposure to maternal immune activation in the offspring. Hasnawati Saleh Monash University Anticipated completion: 2013 The influence of lymphocytes on the metabolism of bone. Rebecca Piganis Monash University Completed: 2010 Mechanism and regulation of Type I IFN signalling. Taryn Rau Monash University Anticipated completion: 2010 An investigation into the interferon response to H5N1 influenza virus to both Nirukshi Samarageewa Monash University mouse and chicken models. Elucidating of the role of CRTC Anticipated completion: 2013 co-activation of CREB in regulating Agnieszka Pindel Monash University promoter II-driven aromatase expression Investigation of a role for PKR in in human breast adipose stromal cells. obesity-related diseases. Raghupathi Ravinarayan Monash University Anticipated completion: 2013 A Novel Mitochondrial DNA (mtDNA) Monash University Mutation Significantly Attenuates Transcription Termination In A Patient With A Mitochondrial Myopathy. Anticipated completion: 2011 Flinders University
112 Southern Health Research Report 2010 113 POSTGRADUATE STUDENTS
Thilini Samarasinghe Melissa Li-Lian Siew Mark Slee The effects of prenatal and maternal Identifying the most effective techniques Mitochondrial dysfunction in multiple stress on cardiovascular dysfunction in for facilitating lung liquid clearance at sclerosis. the newborn. birth in preterm rabbit pups. Anticipated completion: 2015 Anticipated completion: 2013 Anticipated completion: 2011 Flinders University Monash University Monash University Kristina Sobotka Lauren Sanders Elizabeth Sigston Determining the effect of commonly Clinical and immunobiological aspects The role of Laminin-5 in head and neck used medical interventions, surfactant of cerebrovascular disease. squamous cell cancer. and glucocorticoids, on lung structure Anticipated completion: 2013 Anticipated completion: 2014 and function in the extremely immature fetal lung. Monash University Monash University Anticipated completion: 2014 Scott Sands Courtney Simpson Monash University Mechanisms of periodic breathing and Structure and Function of Growth and hypoxemia during apnea in the infant. Differentiation Factor 9 (GDF9). Dhanya Sooraj Completed: 2010 Monash University Characterising and targeting self-renewing, pleuripotent cancer cells (cancer stem Monash University cells) in bladder cancer. Susheel Joginder Singh Anticipated completion: 2017 Padaphet Sayakhot Communication acts of children with Monash University Menopause in women with breast cancer. cerebral palsy. Anticipated completion: 2011 Anticipated completion: 2012 Samantha Speirs Monash University Monash University Psycholinguistic processing in children with autism and Asperger’s disorder. Georg Schmoelzer Suzanne Sinni Anticipated completion: 2011 Respiratory functions during neonatal Measuring patient safety in Monash University resuscitation. maternity services. Anticipated completion: 2011 Anticipated completion: 2011 Rajini Sreenivasan Monash University Monash University Genetic Regulatory mechanisms in mammalian sex determination. Ahrathy Selathurai Carmel Sivaratnam Monash University CD4, CD25 and T cells regulating Social understanding and cognition in atherosclerosis: Mechanisms and children with autism and children with Sebastian Stifter therapeutic potential. attachment disorders. Signalling mechanisms of a novel Anticipated completion: 2011 Anticipated completion: 2014 interferon. Monash University Monash University Anticipated completion: 2013 Monash University Pragati Sharma Elizabeth Hope Skinner The function of de2-7EGFR in glioma. Health-related quality of life, physical function and rehabilitation in survivors George Streitberg Anticipated completion: 2014 of critical illness. Staffing in the clinical chemistry laboratory Monash University Completed: 2010 in relation to technology. University of Melbourne Anticipated completion: 2012 Jake Shortt Charles Sturt University Targeting the PI3K/mTOR pathway in Monika Skubisz pre-clinical models of B-cell neoplasia. Combination methotrexate and gefitinib Bandar Ali Suliman Anticipated completion: 2011 to medically cure ectopic pregnancies: Modulation of interferon sensitivity by PLZF. University of Melbourne phase I and II trials. Anticipated completion: 2013 Anticipated completion: 2014 Monash University Monash University
114 Southern Health Research Report 2010 115 POSTGRADUATE STUDENTS
Shaun Summers Janet Taylor Yuet Mei (Hazel) Tye Toll like receptors and adaptive immune Effect of manual handling on the mobility Characterization of gastric disease in responses in experimental murine of aged care facility residents. gp130 mutant mice. glomerulonephritis. Anticipated completion: 2014 Anticipated completion: 2013 Completed: 2010 Monash University Monash University Monash University Melina Tee Daniela Ulrich Amy Sutherland Cytokines in the pathogenesis of Adult stem cells and novel biomaterials Effect of beth\amethasone and/or peritoneal fibrosis. for tissue engineering a cell-based melatonin on the growth restricted Completed: 2010 therapy for pelvic organ prolapsed. ovine fetus. Monash University Anticipated completion: 2014 Anticipated completion: 2013 Monash University Monash University Adam Testro Toll-like receptor expression and function Suzanita Utama Charmaine Tan in advanced cirrhosis and following liver Monitoring and assessment of nuclear Identification of markers for human transplantation. transfer pregnancies using maternal endometrial carcinoma stem cells. pregnancy recognition proteins. Matthew Thompson Anticipated completion: 2011 Anticipated completion: 2010 Characterizing the function of ATF3 in Monash University Monash University innate immunity and cancer progression. Anticipated completion: 2012 Diana Tan Gabrielle van der Kraan Monash University Regulatory T-Cells in the therapy of The potentiating effects of cell stress autoimmune crescentic glomerulonephritis on pathological bone loss. Laura Tirlea Anticipated completion: 2011 Monash University Evaluation of the ‘Girls on the Go!’ Monash University program through two randomised trials. Michelle Van Sinderen Anticipated completion: 2015 Paisu Tang The role of sex hormones in adiposity Monash University and insulin resistance in the aromatase Functional studies on the ATRX protein. knockout (ArKO) mouse model. Monash University Sarah To Completed: 2010 TNFa in the development and Monash University Elliot Taranto progression of breast cancer. Macrophage migration inhibitory factor Monash University Jubina Venghateri (nee Balan) effects on cell cycle proteins in rheumatoid arthritis’. Anticipated completion: 2011 Generation of induced pluripotent stem Lori Turner cells using a nonintegrating viral vector. Monash University The role of outer membrane vesicles Anticipated completion: 2012 in H.Pylori pathogenesis. Pollyanna Tat Indian Institute of Technology, Bombay Anticipated completion: 2014 and Monash University Factors affecting the reprogramming Monash University efficiency of somatic cells. Rajneesh Verma Completed: 2010 Lana Tutin Application of assisted reproductive Monash University Exploring the area of clinical risk in the technology for the conservation of operating theatre. endangered wild cats. Christopher Tay Anticipated completion: 2014 Anticipated completion: 2013 The atherosclerotic immune Deakin University Monash University mechanisms of B-Lymphocytes. Anticipated completion: 2014 Monash University
114 Southern Health Research Report 2010 115 POSTGRADUATE STUDENTS
Brett Verstak Kevin Wheeler Saroj Yadav Characterisation of the interaction Studies of neonatal volume targeted Generation and characterization of cell between Mal and TRAF6 in Toll-like ventilation. cycle regulation of induced pluripotent receptor signalling. Anticipated completion: 2013 cells (iPSCs). Completed: 2010 Monash University Anticipated completion: 2013 Monash University Indian Institute of Technology, Bombay and Clare Whitehead Monash University Kristi-Ann Villangonzalo Anticipated completion: 2012 Jun Yang Efficacy of N-acetylcysteine in autism: Monash University A double-blind, placebo-controlled Mineralocorticoid receptors - mechanisms randomised trial. of ligand - and tissue-specific activation. Alex Wilding Anticipated completion: 2014 Anticipated completion: 2011 Signalling of the EGFRvIII oncogene in Monash University glioblastoma. Monash University Anticipated completion: 2012 Melanie Anne Voevodin Pinglu (Louie) Ye Monash University Efficacy and economic efficiency of Generation of human endometrium from providing decision support to dietitians embryonic stem cells. Cylie Williams treating people with obesity. Anticipated completion: 2011 Idiopathic toe walking and sensory Anticipated completion: 2013 processing dysfunction. Monash University Monash University Anticipated completion: 2012 Vanessa (Ka Ye) Yeung Charles Sturt University Patricia Vosdoganes The generation of vasopressin secreting Human amniotic epithelial cells in the cells from embryonic and pluripotent Phillip Wong treatment of preterm lung disease. stem cells. Thalassaemia and bone. Anticipated completion: 2014 Anticipated completion: 2014 Monash University Monash University Monash University
Julie Woods Kenneth Walker Liang (Babinski) Yu Impact of fortification of the menu The development and function of high Role of integrin-linked kinase in bladder with protein, calcium and vitamin d on nephron endowment. cancer progression. immunity and infections in institutionalised Monash University elderly people. Anticipated completion: 2013 Anticipated completion: 2013 Monash University Willeke Walsh Monash University 10 year evaluation of an in-hospital falls Natasha Zamudio prevention program. Hui Wu Epigenetic regulation and male fertility. Anticipated completion: 2011 Activin A- A link between inflammation Completed: 2010 University of Melbourne and Diabetes & Hypercholesterolemia. Monash University Anticipated completion: 2012 Qi Feng Wang Monash University An assessment of the medical and psychosocial outcomes of adolescents Michael Wu with heart disease. Assessment of the mechanisms involved Completed: 2010 and the severity of arterial disease in insulin Monash University resistant states including diabetes. On intermission Alana Westover Monash University The role of prostaglandins in the fetal pulmonary response to intrauterine inflammation. Anticipated completion: 2012 Monash University
116 Southern Health Research Report 2010 117 POSTGRADUATE STUDENTS
DOCTORATE OF MEDICINE DOCTORATE OF Rafaela Karas (MD) STUDENTS PSYCHOLOGY (DPSYCH) Depression in young people with autism spectrum disorder. STUDENTS Anticipated completion: 2011 Emma Guymer Monash University Predicting treatment outcomes in Chloe Stanley Carey fibromyalgia. An ocularmotor study comparing Belinda Keenan Anticipated completion: 2013 children with autism and Asperger’s The relationship between attachment disorder. Monash University and social impairment in autism. Anticipated completion: 2011 Anticipated completion: 2014 Dzenana Kartal Monash University Monash University Influence of psycho-social factors and acculturation on psychological Ariane Dowd Angela Khor adaptation of Bosnian refugees in Neuromotor functioning in newly Coping style in Asperger’s Disorder Australia and Austria. diagnosed children with autism. and High Functioning Autism. Anticipated completion: 2013 Anticipated completion: 2011 Anticipated completion: 2013 Monash University Monash University Monash University
Eileen Merriman Belinda Gargaro Simone Kowitz Defining optimal treatment for distal Understanding autism and ADHD. (calf vein) thrombosis Impact of childhood trauma on Anticipated completion: 2011 adjustment following adulthood accident. Anticipated completion: 2018 Monash University Anticipated completion: 2011 Monash University Monash University Eli Gerschman Hang Quach Life meaning, psychological health Anna Makary The clinical role of biological agent in and well-being. the treatment of multiple myeloma & An investigation of cognition and Anticipated completion: 2011 the in vivo immunological effects of iMIDs behaviour during adulthood in in myeloma. Monash University Down syndrome Completed 2010 Anticipated completion: 2014 Alison Gomes University of Melbourne Monash University The impact of stroke on social functioning in children. Lucy McGregor Anticipated completion: 2011 An attachment-based infant-mother Monash University intervention: preliminary study. Phenomenology of post trauma Matthew Jepsen symptoms in refugee youth. The relationship between behaviour Anticipated completion: 2014 and emotional problems and social Monash University skills in adolescents with autism and Asperger’s Disorder. Belinda Melling Anticipated completion: 2011 Family factors in youth school refusal. Monash University Anticipated completion: 2014 Monash University Mary Karamitsios
Gait disorder in young people with Tijana Mihaljcic psychosis. Awareness and falls amongst older Anticipated completion: 2012 hospital patients. Monash University Anticipated completion: 2012 Monash University
116 Southern Health Research Report 2010 117 POSTGRADUATE STUDENTS
Sarah Milsome MASTERS STUDENTS Lorraine Lin Depression in adolescents with The role of Leukaemia inhibitory factor in intellectual disability. endometrial stromal cell decidualization Glenda Bawden Anticipated completion: 2014 (Human and mice). Master of Social Work (Course Work) Monash University Monash University Anticipated completion: 2011
Carlie Park Monash University Cheryl Martin Communicative and language skills Meaning of mental illness in late life. of young high and low functioning Pamela Fernando Master of Social Work (Research) children with autism. Smoking cessation advice delivered by Anticipated completion: 2014 a pharmacist. Anticipated completion: 2011 Monash University Monash University Master of Clinical Pharmacy Completed: 2010 Zoe Milner Jenny Patterson Monash University - Parkville Master of Health Science Evaluating the effects of music and Anticipated completion: 2013 animal-assisted therapy on depression Nick Hall Monash University in aged care residents. The application of mesenchymal stem Anticipated completion: 2011 cells in the spine-effects on fusion, Rim Nour Monash University disc regeneration and modelling a biomimetic disc. Ovarian Phenotype of the IKKb knockout mouse. Beth Williams Master Surgery Monash University Emotion recognition in young children Anticipated completion: 2011 with autism. Monash University Catherine Pilapil Anticipated completion: 2011 The role of Treg in human amnion Seungmin Ham Monash University epithelial cell (hAECs)-mediated The regulation of aromatase by the lung repair. LKB1/AMPK pathway in the testis. Master Biomedical Science Monash University Anticipated completion: 2011 Monash University Kanika Jain Differentiation of mouse embryonic Gita Pratama stem cells to hepatic progenitor cells. The anti-tumour properties of amnion Master Biomedical Science epithelial cells. Completed: 2010 Master Reproductive Science Monash University Anticipated completion: 2010 Monash University Glenda Kerridge Master of Social Work (Course Work) Gaylene Reid Anticipated completion: 2011 Master of Social Work (Course Work) Monash University Anticipated completion: 2011 Monash University Hadeel Khalil Khayat Developing an iPSC approach for Andrew Rodda conservation. Functionalised nanofibres for neural Master Biomedical Science tissue engineering. Anticipated completion: 2011 Master Engineering Science (Research) Monash University Anticipated completion: 2012 Monash University
118 Southern Health Research Report 2010 119 POSTGRADUATE STUDENTS
Debora Alejandra Romero Jennifer Ward Study of the secretory protein products Master of Social Work (Course Work) of mouse Leydig cells in vitro and in vivo Anticipated completion: 2011 following gonadotropin treatment. Monash University Master Reproductive Science Anticipated completion: 2011 Fangyuan ‘Wendy’ Yang Monash University Postnatal growth & development of the mouse epidiymis and the use of Catherine Salmon the label retaining cell approach to Social work in secure mental health identify adult stem cells. inpatient services: towards cultural Master Biomedical Science competence. Completed: 2010 Master of Social Work (Research) Monash University Anticipated completion: 2011 University of Melbourne Heba Mohamedzaki N Zahid Refining ovarian tissue cryopreservation Tamica Sturgess in domestic species. Physiotherapy after open heart surgery Master Biomedical Science Completed: 2010 Anticipated completion: 2011 University of Melbourne Monash University
Jean Tan Leyla Zaker-Tabrizi Role of macrophages in hAEC mediated Structure function studies of lung repair in a bleomycin mouse model interferon-receptor interactions. of lung injury. Master Biomedical Science Master Biomedical Science Anticipated completion: 2011 Anticipated completion: 2011 Monash University Monash University
Sean Vendervert M.Appl.Sci (Course Work) Completed: 2010 RMIT University
Brooke Wadsworth Use of abdominal binders amongst people with spinal cord injury. Master Philosophy Anticipated completion: 2011 University of Queensland
118 Southern Health Research Report 2010 119 POSTGRADUATE STUDENTS
FUNDING SOURCES
We acknowledge and thank our supporters and funding organisations, including trusts, foundations and corporate sponsors.
INSTITUTIONAL SUPPORT Australian Nuclear Science & Concord Clinical trials Technology Organisation CONRAD ANZAC Institute Australian Paediatric Endocrine Group (APEG) Dairy Futures CRC Arthritis Australia Australian Primary Health Care Dementia Collaborative Research Association for International Cancer Research Institute Centre Research (AICR) Australian Research Council (ARC) Dietitians Association of Australia Australia and New Zealand College Linkages of Anaesthetists (ANZCA) Flinders Coordinating Centre Australian Rotary Health Australian Association of Gerontology Haematology Society of Australia & (AAG) - RM Gibson Scientific Australian Synchrotron New Zealand Research Fund Australasian Gynaecological International Society for Interferon & Australian Association of Social Endoscopy & Surgery Society Ltd Cytokine Research Workers (AGES) Medical Advances Without Animals Australian Government, Department Australasian Kidney Trials Network of Education, Employment and Melbourne Health Workplace Relations beyondblue Monash IVF Australian Government, Department BUPA Monash University of Health and Ageing Cancer Council of Victoria Monash University - Faculty of Medicine, Australian Government, Department Caulfield Hospital Nursing & Health Sciences of Innovation, Industry, Science and Research Children’s Hospital Philadelphia Multiple Sclerosis Research Association (CHOP) of Australia
120 Southern Health Research Report 2010 121 FUNDING SOURCES
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JOURNAL ARTICLES Abdelmoneim SS, Bernier M, Scott CG, Aitken RJ, De Iuliis GN, Finnie JM, Hedges Dhoble A, Ness SA, Hagen ME, Moir A, McLachlan RI. Analysis of the S, McCully RB, Pellikka PA, Mulvagh relationships between oxidative stress, Abdelmoneim SS, Bernier M, Dhoble A, SL. Safety of contrast agent use DNA damage and sperm vitality in Moir S, Hagen ME, Ness SA, Abdel- during stress echocardiography in a patient population: development Kader SS, Pellikka PA, Mulvagh SL. patients with elevated right ventricular of diagnostic criteria. Human Assessment of myocardial perfusion systolic pressure: a cohort study. Reproduction 2010;25:2415-2426. during adenosine stress using real time Circ Cardiovasc Imaging. 2010 three-dimensional and two-dimensional May;3(3):240-8. Alderuccio F, Chan J, Ko HJ, Chung JY, myocardial contrast echocardiography: Nasa Z, Toh BH. A molecular Trojan comparison with single-photon Abrahamson SJ, Enticott PG, Tonge horse: hijacking the bone marrow emission computed tomography. BJ. High functioning Pervasive to treat autoimmune diseases. Echocardiography. 2010 Apr;27(4): Developmental Disorders in adults. Discov Med. 2010 Jun;9(49):512-8. 421-9. The Medical Journal of Australia. 2010;192(1), 44-48. Allan CA and McLachlan RI. Androgens Abdelmoneim SS, Bernier M, Dhoble A, and Obesity. Current Opinion in, Moir S, Hagen ME, Ness SA, Pellikka Agar JW, Hawley CM, George CR, Mathew Endocrinology, Diabetes and Obesity. PA, Abdel-Kader SS, Mulvagh SL. TH, McDonald SP, Kerr PG. Home 2010June; 17(3):224-232. Diagnostic accuracy of contrast haemodialysis in Australia - is the echocardiography during adenosine wheel turning full circle? Med J Aust. Allan CA, Strauss BJ, Forbes EA, Paul stress for detection of abnormal 2010 Apr 5;192(7):403-6. E, McLachlan RI. Variability in total myocardial perfusion: a prospective testosterone levels in ageing men with comparison with technetium-99 m Ahmed N, Abubaker K, Findlay J, Quinn symptoms of androgen deficiency. sestamibi single-photon emission M. Epithelial mesenchymal transition Int J Androl. 2010;33:1-5. computed tomography. Heart Vessels. and cancer stem cell-like phenotypes 2010 Mar;25(2):121-30. Epub 2010 facilitate chemoresistance in recurrent Allison BJ, Crossley KJ, Flecknoe SJ, Mar 26. ovarian cancer. Current Cancer Drug Morley CJ, Polglase GR, Hooper SB. Targets 2010;10:268-278. Pulmonary hemodynamic responses to in utero ventilation in very immature fetal sheep. Respir Res. 2010;11:111.
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Allison CC, Ferrero RL. Role of virulence Asselin-Labat ML, Vaillant F, Sheridan JM, Barnes EC, Said N, Williams ED, Hooper factors and host cell signaling in the Pal B, Wu D, Simpson ER, Yasuda H, JNA, Davis RA. Ecionines A and B, two recognition of Helicobacter pylori and Smyth GK, Martin TJ, Lindeman GJ, new cytotoxic pyridoacridine alkaloids the generation of immune responses. Visvader JE 2010 Control of mammary from the Australian marine sponge, Future Microbiol. 2010;5(8):1233-55. stem cell function by steroid hormone Ecionemia geodides. Tetrahedron. signalling. Nature 465:798-802. 2010;66(1):283-7. Anderson SE, Siebenrock KA, Tannast M. Femoroacetabular impingement: Atkin N, Jackson K, Danks A. Bilateral Beaulieu E, Green L, Elsby L, Alourfi evidence of an established hip Open Thoracic Cordotomy for Z, Morand EF, Ray DW, Donn R. abnormality. Radiology 2010 Refractory Cancer Pain: A neglected Identification of a novel cell Oct;257(1):8-13. technique? Journal Pain and Symptom type-specific intronic enhancer of Management 2010; 39(5):924-929. macrophage migration inhibitory Andrews PC, Busse M, Deacon GB, factor (MIF) and its regulation by Ferrero RL, Junk PC, Huynh KK, Backholer K, Bowden M, Gamber K, mithramycin. Clin Exp Immunol. Kumar I, Maclellan JG. Structural and Bjorbaek C, Iqbal J, Clarke IJ 2010 2011 Feb;163(2):178-88. solution studies of phenylbismuth(III) Melanocortins mimic the effects of sulfonate complexes and their activity leptin to restore reproductive function Beaulieu E, Ngo D, Santos L, Yang YH, against Helicobacter pylori. Dalton in lean hypogonadotropic ewes. Smith M, Jorgensen C, Escriou V, Trans. 2010;39(40):9633-41. Neuroendocrinology 91:27-40 Scherman D, Courties G, Apparailly F, Morand EF. Glucocorticoid-induced Andrews PC, Ferrero RL, Junk PC, Bagheri-Fam S, Sinclair AH, Koopman P, leucine zipper is an endogenous Kumar I, Luu Q, Nguyen K, Taylor JW. Harley VR 2010 Conserved regulatory antiinflammatory mediator in arthritis. Bismuth(III) complexes derived from modules in the Sox9 testis-specific Arthritis Rheum. 2010 Sep;62(9): non-steroidal anti-inflammatory drugs enhancer predict roles for SOX, TCF/ 2651-61. and their activity against Helicobacter LEF, Forkhead, DMRT, and GATA pylori. Dalton Trans. 2010;39(11): proteins in vertebrate sex determination. Berk M, Hallam K, Malhi GS, Henry L, 2861-8. International Journal of Biochemistry Hasty M, Macneil M, Yucel M, Pantelis and Cell Biology 42:472-477 C, Murphy B, Vieta E, Dodd S, McGorry Ang AY, Cooper I and Jenkins S. Sexual PD. Evidence and implications for early professional boundaries: physiotherapy Bailey, HD, Armstrong BK, deKlerk NH, intervention in bipolar disorder. Journal students’ experiences and opinions. Fritschi L, Attia J, Lockwood L, Milne of Mental Health (2010) 19, 2: 1-13 NZ J of Physiotherapy 2010:38(3): E; Aus-ALL Consortium collaborators 106-112. (24), Armstrong BK, Milne E, van Bernard P, Harley VR. Acquisition of SOX Bockxmeer FM, Haber M, Scott RJ, transcription factor specificity through Ang DK, Oates CV, Schuelein R, Kelly Attia J, Norris MD, Bower C, de Klerk protein-protein interaction, modulation M, Sansom FM, Bourges D, Boon NH, Fritschi L, Kees UR, Miller M, of Wnt signalling and post-translational L, Hertzog PJ, Hartland EL, van Thompson JR, Bailey HD, Alvaro F, modification. International Journal Driel IR. Cutting edge: pulmonary Cole C, Dalla Pozza L, Daubenton of Biochemistry and Cell Biology Legionella pneumophila is controlled J, Downie PA, Lockwood L, Kirby M, 2010;42:400-410 by plasmacytoid dendritic cells Marshall G, Smibert ES, Suppiah R. but not type I IFN. J Immunol. Exposure to diagnostic radiological Berry PA, Wluka AE, Davies-Tuck ML, 2010;184(10):5429-33. procedures and the risk of childhood Wang Y, Strauss BJ, Dixon JB, acute lymphoblastic leukemia. Cancer Proietto J, Jones G, Cicuttini FM. Apostolopoulos J, Moussa L, Tipping PG. Epidemiology Biomarkers Prev 2010; The relationship between body The cytoplasmic domain of tissue factor Nov 19(11):2897-909 Epub 2010 composition and structural changes restricts physiological albuminuria and Sep 22. at the knee. Rheumatology (Oxford). pathological proteinuria associated with 2010 Dec;49(12):2362-9. glomerulonephritis in mice. Nephron Bajel A, Bazargan A, Doery JCG, Roy S. Exp Nephrol. 2010;116(4):e72-83. Lymphocyte vacuolation: clue Berry PA, Wluka AE, Davies-Tuck ML, to inherited metabolic disease. Wang Y, Strauss BJ, Dixon JB, Arlaud JJ, Baker L, Williams RL, French Pathology 2010; 42: 699-700. Proietto J, Jones G, Cicuttini FM. AJ. Oestrous synchronization, ovarian Sex differences in the relationship superovulation and intraspecific Ball MK, Hillman NH, Kallapur SG, between bone mineral density and transfers from a closed breeding colony Polglase GR, Jobe AH, Pillow JJ. tibial cartilage volume. Rheumatology of inbred SLA miniature pigs. Reprod Body temperature effects on lung (Oxford). 2011 Mar;50(3):563-8. Domest Anim. 2010;45(6):951-8. injury in ventilated preterm lambs. Resuscitation. 2010;81(6):749-54.
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Berzsenyi MD, Roberts SK, Preiss S, Bohensky MA, Jolley D, Sundararajan V, Bray JE, O’Connell B, Gilligan A, Livingston Woollard DJ, Beard MR, Skinner NA, Evans S, Pilcher DV, Scott I, Brand CA. PM, Bladin C. Is FAST Stroke Smart? Bowden DS, Visvanathan K. Hepatic Data linkage: a powerful research tool Do the content and language used TLR2 & TLR4 expression correlates with potential problems. BMC Health in awareness campaigns describe with hepatic inflammation and Serv Res. 2010;10:346. the experience of stroke symptoms? TNF-α in HCV & HCV/HIV infection. International Journal of Stroke 2010; J Viral Hepat. 2010 Nov 3. doi: Boon WC, Chow JD, Simpson ER. 5:440-6. 10.1111/j.1365-2893.2010.01390.x. The multiple roles of estrogens and [Epub ahead of print] the enzyme aromatase. Progress in Brennan SL, Cicuttini FM, Shortreed S, Brain Research 2010;181:209-232 Forbes A, Jones G, Stuckey S, Wluka Beverdam A, Svingen T, Bagheri-Fam AE. Women lose patella cartilage at S, McClive P, Sinclair AH, Harley VR, Boudville N, Kanellis J. The CARI a faster rate than men: a 4.5-year Koopman P. Protein tyrosine kinase 2 guidelines. Donors at risk: proteinuria. cohort study of subjects with knee OA. beta (PTK2B), but not focal adhesion Nephrology, 15 (S1): S106-S110, 2010. Maturitas 2010 Nov;67(3):270-4. Epub kinase (FAK), is expressed in a sexually 2010 Aug 12. Bourke R, Anderson V, Yang J, Jackman dimorphic pattern in developing mouse A, Killedar A, Nixon GM, Davey MJ, gonads. Developmental Dynamics Brown KA, Hunger NI, Docanto M, Walker A Trinder J, Horne RSC. 2010;239:2735-2741 Simpson ER. Metformin inhibits Neurobehavioral function is impaired aromatase expression in human Biggs SN, Bauer KMM, Peters J, Dorrian J, in children with all severities of sleep breast adipose stromal cells via Kennedy JD, Martin AJ, Lushington K. disordered breathing. Sleep Medicine stimulation of AMP-activated protein Acute sleep restriction does not affect 2010; in press. kinase. Breast Cancer Research and declarative memory in 10-year-old Treatment 2010;123:591-596 Bourke RS, Anderson V, Yang JSC, girls. Sleep and Biological Rhythms. Jackman A, Killedar A, Nixon GM, 2010;8(3):222-5. Brown KA, Simpson ER. Obesity Davey MJ, Walker AM, Trinder J, Horne and breast cancer: progress to Biggs SN, Pizzorno VA, van den Heuvel RSC. Cognitive and academic functions understanding the relationship. CJ, Kennedy JD, Martin AJ, Lushington are impaired in children with sleep Cancer Research 2010;70:4-7 K. Differences in parental attitudes disordered breathing. Sleep Medicine towards sleep and associations with 2010; in press. Brown RA, Williams M, Barker CM, sleep-wake patterns in Caucasian Mauri L, Meredith IT, Fajadet J, Wijns Bowden MA, Drummond AE, Fuller PJ, and Southeast Asian school-aged W,Leon MB, Kandzari DE. Sex-specific Salamonsen LA, Findlay JK, and Nie children in Australia. Behav Sleep Med. outcomes following revascularization G. High temperature requirement factor 2010;8(4):207-18. with zotarolimus-eluting stents: A3 (Htra3): a novel serine protease and comparison of angiographic and Bilardi JE, De Guingand DL, Temple-Smith its potential role in ovarian function and late-term clinical results. Catheter MJ, Garland S, Fairley CK, Grover S, ovarian cancers. Molecular and Cellular Cardiovasc Interv. 2010 Nov Wallace E, Hocking JS, Tabrizi S, Pirotta Endocrinology 2010; 327:13-18. 15;76(6):804-13. M, Chen MY. Young pregnant women’s Braatz B, Evans R, Kelman A, Cheng W. views on the acceptability of screening Brown T, Boyle MJ, Williams B, Molloy A, Perinatal evolution of mesenchymal for Chlamydia as part of routine McKenna L, Palermo C, Lewis B, hamartoma of the chest wall. J Pediatr antenatal care. BMC Public Health Molloy L. Listening styles of Surg. 2010 Dec;45(12):e37-40. 2010; 10:505. undergraduate health students. Educ Health (Abingdon). 2010 Nov;23(3):424. Bradford J, Gillespie EE. Ramsden CR, Billah B, Reid CM, Shardey GC, Smith JA. Doherty RR, Stuart RL. Screening A preoperative risk prediction model Brown T, Williams B, Boyle M, Molloy A, following exposure to congenital for 30 day mortality following cardiac McKenna L, Palermo C, Molloy L, tuberculosis in a neonatal nursery. surgery in an Australian cohort. Eur J Lewis B. Communication styles of Healthcare Infect 2010; 115(1) 11–14. Cardiothorac Surg 2010;37:1086-92. undergraduate health students. Nurse Educ Today. 2010 Jul 22. Braitberg G, Oakley E. Small Dose… Billett S, Newton J, Ockerby C. Socio- big poison. Aust Fam Physician. personal premises for selecting and Brown T, Williams B, McKenna L, Palermo 2010;11: 826-833. securing an occupation as vocation. C, McCall L, Roller L, Hewitt L, Molloy L, Baird M, Aldabah L. Practice education Studies in the Education of Adults 2010; Brand CA, Sundararajan V. A 10-year learning environments: The mismatch 42(1):47-62. cohort study of the burden and risk between perceived and preferred of in-hospital falls and fractures expectations of undergraduate health using routinely collected hospital science students. Nurse Educ Today. data. Qual Saf Health Care. 2010 2010 Dec 3. Dec;19(6):e51.
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Bryant PA, Tebruegge M, Papadakis G, Capito C, Leclair MD, Arnaud A, David Chand AL, Harrison CA, Shelling AN. Clarke C, Barnett P, Daley AJ, South A, Baron S, Corradini N, et al. 46,XY Inhibin and premature ovarian M, Curtis N. Clinical and microbiologic pure gonadal dysgenesis: Clinical failure. Human Reproduction Update features associated with novel presentations and management of the 2010;16:39-50 swine-origin influenza A pandemic tumor risk. J Pediatr Urol 2011: Feb;7 2009 (H1N1) virus in children: a (1):72-5. Chand AL, Herridge KA, Thompson EW, prospective cohort study. Pediatr Clyne CD. The orphan nuclear receptor Infect Dis J 2010; Aug;29(8):694-8. Carlos CR, Goergen S. Introduction: quality LRH-1 promotes breast cancer motility in diagnostic imaging: learning from and invasion. Endocrine-Related Buonamici S, Williams J, Morrissey M, worldwide initiatives. J Am Coll Radiol. Cancer 2010;17:965-975 Wang A, Guo R, Vattay A, Hsiao K, 2010 Aug;7(8):563-4. Yuan J, Green J, Ospina B, Yu Q, Chang AB, Bell SC, Byrnes CA, Grimwood Ostrom L, Fordjour P, Anderson DL, Carrera F, Lok CE, de Francisco A, K, Holmes PW, King PT, Kolbe J, Monahan JE, Kelleher JF, Peukert S, Locatelli F, Mann JF, Canaud B, Kerr Landau LI, Maguire GP, McDonald Pan S, Wu X, Maira SM, PG, Macdougall IC, Besarab A, Villa G, MI, Reid DW, Thien FC, Torzillo PJ. Garcia-Echeverria C, Briggs KJ, Kazes I, Van Vlem B, Jolly S, Beyer U, Chronic suppurative lung disease and Watkins DN, Yao YM, Lengauer C, Dougherty FC. Maintenance treatment bronchiectasis in children and adults in Warmuth M, Sellers WR, Dorsch of renal anaemia in haemodialysis Australia and New Zealand. Med J Aust. M. Interfering with resistance to patients with methoxy polyethylene 2010 Sep 20;193(6):356-65. smoothened antagonists by inhibition of glycol-epoetin beta versus darbepoetin Chattopadhyay S, Marques JT, Yamashita the PI3K pathway in medulloblastoma. alfa administered monthly: a M, Peters KL, Smith K, Desai A, Sci Transl Med. 2010;2(51):51ra70. randomized comparative trial. Nephrol Dial Transplant. 2010 Williams BRG, Sen GC. Viral apoptosis Cabalag MS, Taylor DM, Knott JC, Dec;25(12):4009-17. is induced by IRF-3-mediated activation Buntine P, Smit D, Meyer A. Recent of Bax. EMBO J. 2010;29(10):1762-73. caffeine ingestion reduces adenosine Castanelli D, Stevens K, Monagle J. The Chen QZ, Li YA, Jin LY, Quinn JMW, efficacy in the treatment of paroxysmal provision of anaesthesia for children Komesaroff PA. A new sol-gel process supraventricular tachycardia. by nonsubspecialists: expectations of for producing Na2O-containing Academic Emergency Medicine. newly qualified consultant anaesthetists bioactive glass ceramics. Acta 2010; 17(1):44-9. and their prospective employers in Victoria. Anaesth Intensive Care. Biomaterialia 2010;6:4143-4153 Cain JE, Di Giovanni V, Smeeton 2010 38: 911-919. Chen QZ, Zhou X, Quinn JM, Komesaroff J, Rosenblum ND. Genetics of PA, Thouas G. Bone-like elastomer- renal hypoplasia: insights into Chamberlain S, Healy DL. Article for toughened scaffolds with degradability the mechanisms controlling comment: is in vitro fertilisation more kinetics matching healing rates of nephron endowment. Pediatr Res. effective than stimulated intrauterine injured bone. Advanced Biomaterials 2010;68(2):91-8. insemination as a first-line therapy for subfertility? A cohort analysis. 2010;12:B642-B648 Callisaya ML, Blizzard L, McGinley JL, Chambers GM, Sullivan EA, Shanahan Cheng Q, McKeown SJ, Santos L, Schmidt MD, Srikanth VK. Sensorimotor M, Ho MT, Priester K, Chapman MG. Santiago FS, Khachigian LM, Morand factors affecting gait variability in older Aust N Z J Obstet Gynaecol. 2010 EF, Hickey MJ. Macrophage migration people-a population-based study. Dec;50(6):583; author reply -4. inhibitory factor increases leukocyte- J Gerontol A Biol Sci Med Sci. 2010 endothelial interactions in human Apr;65(4):386-92. Chan A, Neeson P, Leeansyah E, Tainton K, Quach H, Godfrey D, Prince M, Ritchie endothelial cells via promotion of Callisaya ML, Blizzard L, Schmidt MD, D and Berzins P. Revlimid treatment expression of adhesion molecules. McGinley JL, Srikanth VK. Ageing and of myelodysplastic syndromes (MDS) J Immunol. 2010 Jul 15;185(2):1238-47. gait variability-a population-based study invokes a positive clinical response Cheng WS, Roberts SK, McCaughan G, of older people. Age Ageing. 2010 without modulating NKT cell frequency Sievert W, Weltman M, Crawford D, Mar;39(2):191-7. or function [original study]. Leukemia Rawlinson W, Marks PS, Thommes J, 2010; 24(3):592-600. Cameron D, Murphy A, Morris ME, Raghav Rizkalla B, Yoshihara M, Dore GJ. S, Iansek R. Planned stopping in Chan J, Nirwati H, Triasih R, Bogdanovic- Low virological response and high people with Parkinson. Parkinsonism Sakran N, Soenarto Y, Hakimi M, Duke relapse rates in hepatitis C genotype and Related Disorders 2010;16:191-96. T, Buttery JP, Bines JE, Bishop RF, 1 patients with advanced fibrosis Kirkwood CD, Danchin MD. Maternal despite adequate therapeutic dosing. antibodies to rotavirus: could they J Hepatol. 2010 Oct;53(4):616-23. interfere with live rotavirus vaccines in developing countries? Vaccine. 2011 Feb 1;29(6):1242-7.
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Cherian S, Burgner D, Cooke A, Sanfilipo Chui A, Pathirage NA, Johnson B, Connell TG, Tebruegge M, Ritz N, Bryant F, Forbes D. Associations between Cocquebert M, Fournier T, Evain-Brion PA, Leslie D, Curtis N. Indeterminate Helicobacter pylori infection, co-morbid D, Roald B, Manuelpillai U, Brennecke interferon-gamma release assay results infections, gastrointestinal symptoms SP, Kalionis B, Murthi P. Homeobox in children. Pediatr Infect Dis J 2010; and circulating cytokines in African gene distal-less 3 is expressed in Mar;29(3):285-6. children. Helicobacter 2010; 15(2): proliferating and differentiating cells 88-97. of the human placenta. Placenta. Coombs PR, Downie R, Phan TG. 2010;31(8):691-7. Disappearing flapping plaque in the Cheung AL, Wilcox G, Walker KZ, Shah NP, internal carotid artery. Ann Vasc Surg Strauss B, Ashton JF, Stojanovska L. Clarke DM. No cancer health without 2010 Feb; 24(2):254.e7-9. Epub 2010 Fermentation of calcium-fortified soya mental health (editorial). Medical Jan 4. milk does not appear to enhance Journal of Australia 2010; 193(suppl): acute calcium absorption in osteopenic S43. Cooney MA, Malcuit C, Cheon B, post-menopausal women. Br J Nutr. Holland MK, Fissore RA, D’Cruz NT. 2011 Jan;105(2):282-6. Clerc RG, Stauffer A, Weibel F, Hainaut Species-specific differences in the E, Perez A, Hoflack JC, Benardeau activity and nuclear localization of Chiew A, Day P, Salonikas C, Naidoo A, Pflieger P, Garriz JMR, Funder JW, murine and bovine phospholipase C D, Graudins A, Thomas R. The Capponi AM, Niesor EJ. Mechanisms zeta 1. Biol Reprod. 2010;83(1):92-101. comparative pharmacokinetics of underlying off-target effects of the modified-release and immediate- cholesteryl ester transfer protein Corben LA, Delatycki MB, Bradshaw JL, release paracetamol in a simulated inhibitor torcetrapib involve L-type Horne MK, Fahey MC, Churchyard AJ, overdose model. Emerg Med Australas. calcium channels. Journal of Georgiou-Karistianis N. Impairment 2010 Dec;22(6):548-55. Hypertension 2010;28:1676-1686 in motor reprogramming in Friedreich ataxia reflecting possible cerebellar Chong B, Gan E, Bird R, Pidcock M, Clifford V, Wadsley J, Jenner B, Buttery JP. dysfunction. J Neurol. 2010 Lloyd, Tay L, Bake R, Stone C, Maher Mumps vaccine associated orchitis: May;257(5):782-91. D. An Open Label Multicentre Study Evidence supporting a potential Evaluating the Efficacy and Safety immune-mediated mechanism. Corben, L.A., Tai, G., Wilson, C., Collins, V., of a New 10% Liquid Intravenous Vaccine. 2010 Mar 19;28(14):2671-3. Churchyard, A.J., Delatycki M.B. (2010). Immunoglobulin in Patients with Primary A comparison of three measures of Immune Thrombocytopenia (ITP). Cohney S, Kanellis J, Howell M. The upper limb function in Friedreich ataxia. APJOH 2010;2(2). November 2010. CARI guidelines. Donor renal function. Journal of Neurology, 257(4): 518 -523. Nephrology, 15 (S1): S137-S145, 2010. Chong M, Frydenberg M. Surveillance of Cornish KM, Gray KM, & Rinehart NJ. (). renal masses in a single urologist’s Collins JJ, Kallapur SG, Knox CL, Nitsos Fragile X syndrome and associated cohort; survival and outcomes. I, Polglase GR, Pillow JJ, Kuypers disorders. In J. Holmes (Ed.), Advances BJU International 2010; 105: 22 E, Newnham JP, Jobe AH, Kramer in child development and behavior BW. Inflammation in fetal sheep from 2010;(Vol. 39, pp. 211-235) Chronic Kidney Disease Prognosis intra-amniotic injection of Ureaplasma Consortium, Matsushita K, van der parvum. Am J Physiol Lung Cell Mol Coveney N, Polkinghorne KR, Linehan L, Velde M, Astor BC, Woodward M, Physiol. 2010;299(6):L852-60. Corradini A, Kerr PG. Water-soluble Levey AS, de Jong PE, Coresh vitamin levels in extended hours J, Gansevoort RT. Association of Comans T, Brauer S, Currin M, Haines T. hemodialysis. Hemodial Int. 2010 estimated glomerular filtration rate Randomised trial of domiciliary versus Nov 24. and albuminuria with all-cause and centre-based rehabilitation: Which is Cowin PA, Gold E, Aleksova J, O’Bryan cardiovascular mortality in general more effective in reducing falls and MK, Foster PM, Scott HS, Risbridger population cohorts: a collaborative improving quality of life in older fallers? GP. Vinclozolin exposure in utero meta-analysis. Lancet. 2010 Jun Journals of Gerontology (Medical induces postpubertal prostatitis 12;375(9731):2073-81. Sciences) (Accepted Apr 2010). and reduces sperm production via Chu KY, Cheng QN, Chen C, Au LS, Seto Combes AN, Spiller CM, Harley VR, a reversible hormone-regulated SW, Tuo Y, Motin L, Kwan YW, Leung Sinclair AH, Dunwoodie SL, Wilhelm D, mechanism. Endocrinology. PS. Angiotensin II exerts glucose- Koopman P. Gonadal defects in Cited2 2010;151(2):783-92. dependent effects on K-v currents -mutant mice indicate a role for SF1 Craig S, Braitberg G, Nicolas C, White in mouse pancreatic beta-cells via in both testis and ovary differentiation. G, Egerton-Warburton D. Assessment angiotensin II type 2 receptors. International Journal of Developmental and feedback in emergency medicine American Journal of Physiology-Cell Biology 2010;54:683-689 training: views of Australasian Physiology 2010;298:C313-C323 emergency trainees. Emerg Med Australas. 2010 Dec;22(6):537-47.
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Craig S, Braitberg G, Nicolas C, White G. Crosbie JC, Anderson RL, Rothkamm K, Deeks AA, Gibson-Helm ME, Teede HJ. “Scrap it”, “Drop it”, “Get rid of it”, “I Restall CM, Cann L, Ruwanpura S, Anxiety and depression in polycystic hated it”. What do ACEM trainees really Meachem S, Yagi N, Svalbe I, Lewis RA, ovary syndrome: A comprehensive think of the 4-10 project? A qualitative Williams BRG, Rogers PAW. Tumor cell investigation. Fertility and Sterility study. Emergency Medicine Australasia. response to synchrotron microbeam 2010;93(7):2421-3. 2010 (in press). radiation therapy differs markedly from cells in normal tissues. Int J Radiat Delany CM, Edwards I, Jensen GM, Craig S, Braitberg G, Nicolas C, White G. Oncol Biol Phys. 2010;77(3):886-94. Skinner E. Closing the gap between What do ACEM trainees really think of ethics knowledge and practice the primary examination? A qualitative Cross WM, Moore A, Ockerby C. Clinical through active engagement: an study. Emergency Medicine Australasia. supervision of general nurses in a busy applied model of physical therapy 2010 (in press). medical ward of a teaching hospital. ethics. Phys Ther 2010:1068-1078. Contemporary Nurse 2010; 35(2): Craig S, Braitberg G, Nicolas C, White G. 245-53. Demant AW, Bangard C, Bovenschulte What do ACEM trainees really think H, Skouras E, Anderson SE, Lackner of the fellowship examination? Custovic A, Simpson A, Bardin PG, K. MDCT evaluation of the spectrum A qualitative study. Emergency Le Souef P. Allergy is an important of injuries after tram accidents in Medicine Australasia. 2010 (in press). factor in asthma exacerbation: a pedestrians. Emerg Radiol 2010 pro/con debate. Respirology. March;17(2):103-108. Craig S, Braitberg G, Nicolas C, White G. 2010 Oct;15(7):1021-7. What do ACEM trainees think of their Denholm JT, Gordon CL, Johnson PD, supervision and feedback at work? A Czajka-Oraniec I, Simpson ER. Aromatase Hewagama SS, Stuart RL, Aboltins qualitative study. Emergency Medicine research and its clinical significance. C, Jeremiah C, Knox J, Lane GP, Australasia. 2010 (in press). Endokrynologia Polska 2010;61: Tramontana AR, Slavin MA, Schulz 126-134 TR, Richards M, Birch CJ, Cheng Craig S. Direct Observation of Clinical AC. Hospitalised adult patients with Practice in Emergency Medicine Czernichow S, Kengne AP, Huxley RR, pandemic (H1N1) 2009 influenza in Education. Acad Emerg Med. 2010 Batty GD, de Galan B, Grobbee D, Melbourne, Australia. Med J Aust. Dec 22. (In press) Pillai A, Zoungas S, Marre M, 2010 Jan 18;192(2):84-86. Woodward M, Neal B, Chalmers J; on Crawford NW, Buttery JP. Polio behalf of the ADVANCE Collaborative Devi S, Kuligowski MP, Kwan RY, Westein eradication: another step forward. Group. Comparison of waist-to-hip ratio E, Jackson SP, Kitching AR, Hickey Invited commentary. Lancet 2010; and other obesity indices as predictors MJ. Platelet recruitment to the inflamed 376(9753):1624-25. of cardiovascular disease risk in people glomerulus occurs via an alphaIIbbeta3/ with type-2 diabetes: a prospective GPVI-dependent pathway. Am J Pathol. Crawford NW, Buttery JP. Preterm infants cohort study from ADVANCE. European 2010 Sep;177(3):1131-42. immunization. Paediatrics and Child Journal of Cardiovascular Prevention Health 2010;20(6):297-301. and Rehabilitation. 2010 Jul 12. doi: Dharane (neé Ligam) P, Manuelpillai U, Wallace E, Walker DW. NF B- Crawford NW, Heath JA, Ashley D, 10.1097/HJR.0b013e32833c1aa3. κ dependent increase of kynurenine Downie P, Buttery JP. Survivors of Dagia C, Ditchfield M, Kean M, et al. pathway activity in human placenta: childhood cancer: an Australian Feasibility of 3T MRI for the evaluation Inhibition by sulfasalazine. Placenta audit of vaccination status after of Crohn disease. Pediatric Radiology 2010; 31:997-1002 treatment. Pediatr Blood Cancer. 2010;40:1615-24. 2010 Jan;54(1):128-133. Diao M, Li L, Cheng W. Laparoscopic Dando SJ, Nitsos I, Newnham JP, Jobe versus Open Roux-en-Y Crittenden PM, & Newman L. Comparing AH, Moss TJ, Knox CL. Maternal hepatojejunostomy for children with models of borderline personality administration of erythromycin fails choledochal cysts: intermediate-term disorder: Mothers’ experience, to eradicate intrauterine ureaplasma follow-up results. Surg Endosc 2010; self-protective strategies, and infection in an ovine model. Biol Oct 29. [Epub ahead of print]. dispositional representations. Reprod. 2010;83(4):616-22. Clinical Child Psychology & Psychiatry Diao M, Li L, Zhang JS, Cheng W. 2010;15(3), 433-451. doi: 15/3/433 de Vries P, Soret R, Suply E, Heloury Y, Laparoscopic-assisted clearance [pii] 10.1177/1359104510368209 Neunlist M. Postnatal development of of protein plugs in the common myenteric neurochemical phenotype channel in children with choledochal and impact upon neuromuscular cysts. J Pediatr Surg. 2010 transmission in the rat colon. Am Oct;45(10):2099-102. J Physiol Gastrointest Liver Physiol 2010:299:539-47.
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Diao M, Li L, Zhang JZ, Cheng W. A shorter Durbin AD, Pasic I, Wong DK, Hannigan Fahim M, Hawley CM, McDonald SP, Brown loop in Roux-Y hepatojejunostomy GE, Malkin D. The oncogenic and FG, Rosman JB, Wiggins KJ, Bannister reconstruction for choledochal cysts growth-suppressive functions of the KM, Johnson DW. Culture-negative is equally effective: preliminary results integrin-linked kinase are distinguished peritonitis in peritoneal dialysis patients of a prospective randomized study. by JNK1 expression in human cancer in Australia: predictors, treatment and J Pediatr Surg. 2010 Apr;45(4):845-7. cells. Cell Cycle. 2010;9(10):1951-9. outcomes in 435 cases. Am J Kid Disease 2010 55(4):690-7. Dimitriadis E, Menkhorst E, Salamonsen Edwards BA, O’Driscoll DM, Ali A, Jordan LA, Paiva P. LIF and IL11 in AS, Trinder J, Malhotra A. Aging and Fahim M, Hawley CM, McDonald SP, Brown trophoblast-endometrial interactions sleep: physiology and pathophysiology. FG, Rosman JB, Wiggins KJ, Bannister during the establishment of pregnancy. Semin Respir Crit Care Med. 2010; KM, Johnson DW. Coagulase-negative Placenta 2010;31 Suppl:S99-104 31(5):618-33. Staphylococal peritonitis in Australian peritoneal dialysis patients: predictors, Dimitriadis E, Nie GY, Hannan NJ, Paiva P, Egerton T, Brauer SG, Cresswell AG. treatment and outcomes in 936 Salamonsen LA. Local regulation Dynamic postural stability is not cases. Nephrol Dial Transplant. 2010; of implantation at the human impaired by moderate-intensity physical 25(10):3386-92. fetal-maternal interface. International activity in healthy or balance-impaired Journal of Developmental Biology older people. Human Movement Fang Z, Kozlov S, McKay MJ, Woods 2010;54:313-322 Science 2010;29(6):1011-22. R, Birrell G, Sprung CN, Murrell DF, Wangoo K, Teng L, Kearsley JH, Ding C, Cicuttini F, Boon C, Boon P, Einfeld SL, Ellis LA, Doran CM, Emerson Lavin MF, Graham PH, Clarke RA. Srikanth V, Cooley H, Jones G. Knee E, Horstead SK, Madden RH, & Tonge Low levels of ATM in breast cancer and hip radiographic osteoarthritis BJ. Behaviour problems increase costs patients with clinical radiosensitivity. predict total hip bone loss in older of care of children with intellectual Genome Integr. 2010;1(1):9. adults: a prospective study. J Bone disabilities. Journal of Mental Health Miner Res. 2010 Apr;25(4):858-65. Research in Intellectual Disabilities, Fehlings, D., Russo, R., Berwick, 2010a; 3(4), 202-209 S., Stott, S., Novak, I., Hoare, B. Ding SZ, Fischer W, Kaparakis-Liaskos M, (2010). Botulinum toxin assessment, Liechti G, Merrell DS, Grant PA, Einfeld SL, Gray KG, Ellis L, Taffe J, intervention and follow-up for paediatric Ferrero RL, Crowe SE, Haas R, Emerson E, Tonge BJ, & Horstead upper limb hypertonicity: International Hatakeyama M, Goldberg JB. SK. Intellectual Disability modifies consensus statement. European Helicobacter pylori-induced histone gender effects on disruptive behaviors. 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The Understanding mirror neurons: Allied health clinicians’ beliefs and ultrasound appearance of the patellar Evidence for enhanced corticospinal attitudes about medication adherence tendon attachment to the tibia in young excitability during the observation in depressive disorders. Journal of athletes is conditional on gender and of transitive but not intransitive Evaluation in Clinical Practice. 2010 pubertal stage. J Sci Med Sport 2010 hand gestures. Neuropsychologia, 16(6):1361-1363 Jan; 13(1): 20-3. 2010a;9:2675-2680. Fielding, J., Corben, L.A., Cremer, P., Millist, Dunbier AK, Hong Y, Masri S, Brown KA, Enticott PG, Rinehart NJ, Tonge BJ, L., White, O. & Delatycki, M.B. (2010). Sabnis GJ, Palomares MR. Progress in Bradshaw JL, & Fitzgerald PB. A Disruption to higher order processes aromatase research and identification preliminary transcranial magnetic in Friedreich ataxia. Neuropsychologia, of key future directions. 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Findlay JK, Liew SH, Simpson ER, Francesconi AB, Dupre S, Matos M, Funder JW, Reincke M. Aldosterone: Korach KS. Estrogen signaling in Martin D, Hughes BG, Wyld DK, a cardiovascular risk factor? the regulation of female reproductive Lickliter JD. Carboplatin and etoposide Biochimica et Biophysica Acta functions. Handbook of Experimental combined with bevacizumab for the 2010;1802:1188-1192 Pharmacology 2010;198:29-35 treatment of recurrent glioblastoma multiforme. Journal of Clinical Gall SL, Donnan G, Dewey HM, Macdonell Fleming NI, Knower KC, Lazarus KA, Neuroscience 2010;17:970-974. R, Sturm J, Gilligan A, Srikanth V, Thrift Fuller PJ, Simpson ER, Clyne CD. AG. Sex differences in presentation, Aromatase is a direct target of FOXL2: Francis JV, Monagle P, Hope S, Sehgal A. severity, and management of stroke in C134W in granulosa cell tumors via a Occlusive aortic arch thrombus in a a population-based study. Neurology. single highly conserved binding site preterm neonate. Pediatr Crit Care 2010 Mar 23;74(12):975-81. in the ovarian specific promoter. Med 2010; Jan;11(1):e13-5. PLoS ONE 2010;5:e14389 Gan PY, Steinmetz OM, Tan DS, O’Sullivan Franco P, Kato I, Richardson HL, Yang JS, KM, Ooi JD, Iwakura Y, Kitching AR, Fogarty GB, Muddle R, Sprung CN, Montemitro E, Horne RS. Arousal Holdsworth SR. Th17 cells promote Chen W, Duffy D, Sturm RA, McKay from sleep mechanisms in infants. autoimmune anti-myeloperoxidase MJ. Unexpectedly severe acute Sleep Med. 2010;11(7):603-14. glomerulonephritis. J Am Soc Nephrol. radiotherapy side effects are 2010 Jun;21(6):925-31. associated with single nucleotide Frauchiger HL, Harstall R, Kajahn J, polymorphisms of the melanocortin-1 Anderson SE, Eggli S. Bilateral total Gantier MP. New perspectives in receptor. Int J Radiat Oncol Biol Phys. knee arthroscopy in a patient with microRNA regulation of innate 2010;77(5):1486-92. hemophilia A, high inhibitor titre and immunity. J Interferon Cytokine Res. aneurysma spurium of the popliteal 2010;30(5):283-9. Folker, J., Murdoch, B., Cahill, L., Delatycki, artery:A case report. Swiss Medical M., Corben, L., Vogel, A. (2010). Weekly SMW. Accepted July 2010. Gantier MP, Irving AT, Kaparakis-Liaskos Dysarthria in Friedreich’s ataxia: a M, Xu D, Evans VA, Cameron PU, perceptual analysis. Folia phoniatrica Funder J. Sumer Is Icumen In: Lessons Bourne JA, Ferrero RL, John M, et logopaedica, 62(3):97-103 from the Lungfish. Endocrinology Behlke MA, Williams BRG. Genetic 2010;151:849-851 modulation of TLR8 response following Folker, J.E., Murdoch, B.E., Cahill, L.M., bacterial phagocytosis. Hum Mutat. Delatycki, M.B., Corben, L.A., Vogel, Funder JW. Aldosterone and 2010;31(9):1069-79. A.P. (2010). Differentiating impairment mineralocorticoid receptors in the levels in temporal versus spatial cardiovascular system. Progress in Gantier MP, Tong S, Behlke MA, Irving aspects of linguopalatal contacts in Cardiovascular Diseases 2010;52: AT, Lappas M, Nilsson UW, Latz E, Friedreich’s ataxia. Motor Control, 393-400 McMillan NAJ, Williams BRG. Rational 14(4):490-508. design of immunostimulatory siRNAs. Funder JW. Aldosterone, sodium, and Mol Ther. 2010;18(4):785-95. Folker, J.E., Murdoch, B.E., Cahill, L.M., hypertension: lessons from torcetrapib? Rosen, K.M., Delatycki, M.B., Corben, Hypertension 2010;55:221-223 Gantier MP, Williams BRG. Monitoring L.A., Vogel, A.P. (2010). Articulatory innate immune recruitment by siRNAs Funder JW. Medicine as a profession. kinematics in the dysarthria associated in mammalian cells. Methods Mol Biol. Clinical Medicine 2010;10:246-247 with Friedreich’s ataxia. Motor Control. 2010;623:21-33. In press. Funder JW. Aldosterone, hypertension Gargett CE. Stem cells in human and heart failure: insights from Foo JH, Culvenor JG, Ferrero RL, Kwok reproduction. Reproduction. clinical trials. Hypertension Research T, Lithgow T, Gabriel K. Both the p33 2010;140(1):1-2. 2010;33:872-875 and p55 subunits of the Helicobacter Gargett CE, Masuda H. Adult stem cells pylori VacA toxin are targeted to Funder JW. Eplerenone in chronic in the endometrium. Mol Hum Reprod. mammalian mitochondria. J Mol Biol. renal disease: the EVALUATE trial. 2010;16(11):818-34. 2010;401(5):792-8. Hypertension Research 2010;33: 539-540 Georg I, Bagheri-Fam S, Knower KC, Foster M, Earl P, Haines T, Mitchell G. Wieacker P, Scherer G, Harley VR. Unraveling the concept of consumer Funder JW. Minireview: Aldosterone and Mutations of the SRY-responsive preference: Implications for health Mineralocorticoid Receptors: Past, enhancer of SOX9 are uncommon policy and optimal planning in primary Present, and Future. Endocrinology in XY gonadal dysgenesis. Sexual care. Health Policy 2010;97(2):105-112. 2010;151:5098-5102 Development 2010;4:321-325
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Girling JE, Donoghue JF, Lederman Gooi JH, Pompolo S, Karsdal MA, Kulkarni Gray KM, Piccinin AM, Hofer SM, FL, Cann LM, Achen MG, Stacker NH, Kalajzic I, McAhren SH, Han B, Mackinnon A, Bontempo DE, Einfeld SA, Rogers PA. Vascular endothelial Onyia JE, Ho PW, Gillespie MT, Walsh SL, Tonge BJ. The longitudinal growth factor-D over-expressing tumor NC, Chia LY, Quinn JM, Martin TJ, Sims relationship between behavior and cells induce differential effects on NA. Calcitonin impairs the anabolic emotional disturbance in young uterine vasculature in a mouse model effect of PTH in young rats and people with intellectual disability and of endometrial cancer. Reprod Biol stimulates expression of sclerostin by maternal mental health. Research Endocrinol. 2010;8:84. osteocytes. Bone 2010;46:1486-1497 in Developmental Disabilities, 2011;32, 1194-1204. doi: 10.1016/j. Givoni N, Palermo C. Monitoring the cost Gordon M, Tonge BJ, & Melvin GA. The ridd.2010.12.044 of healthy food. Aust N Z J Public outcome of adolescent depression: Health. 2010 Aug;34(4):433-4. 6 months after treatment. Aust N Z J Gregory G, Opat S, Quach H, Shortt J, Psychiatry published early online 2010. Tran H. Failure of Eculizumab to correct Goergen S. They don’t know what they Paroxysmal Cold Hemoglobinuria. don’t know. J Med Imaging Radiat Gough DJ, Messina NL, Hii L, Gould JA, Annals of Haematology. 2010 Nov 26. Oncol. 2010 Feb;54(1):1-2. Sabapathy K, Robertson AP, Trapani [Epub ahead of print] JA, Levy DE, Hertzog PJ, Clarke CJ, Goergen SK, Rumbold G, Compton Johnstone RW. Functional crosstalk Green David and McDermott Fiona. G, Harris C. Systematic review of between type I and II interferon through Social work from inside and between current guidelines and their evidence the regulated expression of STAT1. complex systems: perspectives on base, on risk of lactic acidosis after PLoS Biol. 2010;8(4):e1000361. person-in-environment for today’s administration of contrast medium social work. British Journal of Social for patients receiving metformin. Govindarajulu S, Hawley CM, McDonald Work 2010; doi.10.1093/bjsw/bcq056 Radiology 2010 Jan; 254(1):261-9. SP, Brown F, Rosman J, Wiggins KJ, Bannister K, Johnson DW. Grigoriadis G, Anderson MA, Whitehead Gold MB, Buttery JP; McIntyre, P. Human Staphylococcus Aureus peritonitis in S. Charcot Leyden crystals. Int Med J., Papilloma Virus vaccine safety in Australian peritoneal dialysis patients: 2010 (In Press). Australia: experience to date and predictors, treatment and outcomes issues for surveillance. Sexual Health in 503 cases. Perit Dial Int 2010; Grigoriadis G, Teh P, Whitehead S. 2010;7:320-4. 30(3):311-9. Occult Disseminated Malignancy Presenting As Microangiopathic Gold MS, Effler P, Kelly H, Richmond PC, Graham GG, Day RO, Graudins A, Haemolytic Anaemia. Ther Apher Buttery JP. Febrile convulsions after Mohamudally A. FDA proposals to Dial. 2010 (In Press). 2010 seasonal trivalent influenza limit the hepatotoxicity of paracetamol vaccine: implications for vaccine safety (acetaminophen): are they reasonable? Grigoriadis G, Whitehead S. CD138 surveillance in Australia. Med J Aust. Inflammopharmacology.2010 shedding in plasma cell myeloma. 2010 Nov 1;193(9):492-3. Apr;18(2):47-55. Br J Haematol. 2010:150, 249.
Goldschlager T, Abdelkader A, Kerr J, Graham Annette L, Julian John, Meadows Grubman A, Kaparakis M, Viala J, Allison Boundy I, Jenkin G. Undecalcified Graham. Improving responses to C, Badea L, Karrar A, Boneca IG, Le bone preparation for histology, depression and related disorders: Bourhis L, Reeve S, Smith IA, Hartland histomorphometry and fluorochrome Evaluation of an innovative, general, EL, Philpott DJ, Ferrero RL. The innate analysis. J Vis Exp. 2010(35). mental health care workers training immune molecule, NOD1, regulates program. International Journal of direct killing of Helicobacter pylori by Goldschlager T, Ghosh P, Zannettino A, Mental Health Systems. 2010;4:1-13 antimicrobial peptides. Cell Microbiol. Gronthos S, Rosenfeld JV, Itescu S, 2010;12(5):626-39. Jenkin G. Cervical motion preservation Graudins A, Chiew A, Chan BS. Overdose using mesenchymal progenitor cells of modified-release paracetamol results Guastella AJ, Einfeld SL, Gray KM, and pentosan polysulfate, a novel in delayed and prolonged absorption Rinehart NJ, Tonge BJ, Lambert TJ, & chondrogenic agent: preliminary study of paracetamol. Internal Med Journal. Hickie IB. Intranasal oxytocin improves in an ovine model. Neurosurg Focus. 2010; 40(1):72-76. emotion recognition for youth with 2010;28(6):E4. autism spectrum disorders. Biological Graudins A, Wong KK. Comparative Psychiatry, 2010;67(7), 692-694. doi: Goldschlager T, Jenkin G, Ghosh P, hemodynamic effects of levosimendan S0006-3223(09)01122-6 [pii]10.1016/j. Zannettino A, Rosenfeld JV. Potential alone and in conjunction with biopsych.2009.09.020 applications for using stem cells in 4-aminopyridine or calcium chloride spine surgery. Curr Stem Cell Res in a rodent model of severe verapamil Ther. 2010;5(4):345-55. poisoning. J Med Toxicol. 2010 Jun;6(2):85-93.
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Guo J, Tecirlioglu RT, Nguyen L, Koh K, Hare DJ, George JL, Grimm R, Wilkins Hayward CS, Peters WS, Merry AF, Jenkin G, Trounson A. Reprogramming S, Adlard PA, Cherny RA, Bush Ruygrok PN, Jansz P, O’Driscoll G, factors involved in hybrids and cybrids AI, Finkelstein DI, Doble P. Three- Larbalestier RI, Smith JA, Ho B, of human embryonic stem cells fused dimensional elemental bio-imaging Legget ME, Milsom FP. Chronic with hepatocytes. Cell Reprogram. of Fe, Zn, Cu, Mn and P in a extra-aortic balloon counterpulsation: 2010;12(5):529-41. 6-hydroxydopamine lesioned mouse first-in-human pilot study in end-stage brain. Metallomics. 2010;2(11):745-53. heart failure. J Heart Lung Transplant. Haines T, Bell R, Varghese P. Pragmatic, 2010 Dec;29(12):1427-32. cluster randomised trial of a policy Harley V, Lefebvre V. Twenty Sox, to introduce low-low beds to hospital twenty years. International Journal Head G, Mihailidou A, Duggan K, Beilin wards for the prevention of falls and of Biochemistry & Cell Biology L, Berry N, Brown M, Bune A, Cowley fall-injuries. Journal of the American 2010;42:376-377 D, Chalmers J, Howe P, Hodgson J, Geriatrics Society 2010;58:435-441. Ludbrook J, Mangoni A, McGrath B, Harper RW, Lefkovits J. Prehospital Nelson M, Sharman J, Stowasser M. Haines T, Foster M, Cornwell P, Fleming J, thrombolysis followed by early Relationship between ambulatory Tweedy S, Hart A, Mitchell G. Impact of angiography and percutaneous and clinic blood pressure: defining Enhanced Primary Care on equitable coronary intervention where appropriate diagnostic and treatment targets. access to and economic efficiency – an underused strategy for the BMJ 2010;c1104 of allied health services: A qualitative management of STEMI. Med J Aust. investigation. Australian Health Review 2010 Aug 16;193(4):234-7. Review. Head GA, Mihailidou AS, Duggan KA, 2010; 34(1) 30–35. 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Obstetrics after endometriosis. human embryo implantation: choice World Endometriosis Society e-journal Harper RW. Pre-hospital thrombolysis of cell lines? Biology of Reproduction 12;3:3-6. 2010;82:235-245 rather than primary percutaneous intervention is the treatment of choice Healy DL, Breheny S, Halliday J, Jaques Hannan NJ, Stephens AN, Rainczuk A, for patients with ST-segment elevation A, Rushford D, Garrett C, Talbot JM, Hincks C, Rombauts LJ, Salamonsen myocardial infarction presenting early Baker HGW. Prevalence and risk LA. 2D-DiGE analysis of the human after the onset of symptoms. JACC factors for obstetric haemorrhage in endometrial secretome reveals Cardiovasc Interv. 2010 Oct;3(10): 6730 singleton births after assisted differences between receptive and 1093-4; author reply 1094-5. reproductive technology in Victoria nonreceptive states in fertile and Australia. Hum Reprod. 2010 25:265-74 infertile women. J Proteome Res. Harris DM, & Pavlou CT. Meeting workforce 2010;9(12):6256-64. demand in Mental Health. Australian Heffernan C, Whiley PA, Milionis A, Verma Nursing Journal September 2010; PJ, Holland MK, Jans DA, D’Cruz Haralambous B, Haines T, Hill K, Moore 18 (3):43. NT. Lineage-specific expression of K, Nitz J, Robinson A. A protocol heterochromatin protein 1gamma in Harrison CL, Lombard CB, Moran LJ, for an individualised, facilitated and post-compaction, in vitro-produced Teede HJ. Exercise therapy in polycystic sustainable approach to implementing bovine embryos. Reprod Fertil Dev. ovary syndrome: A systematic review. current evidence in preventing falls in 2010;22(6):1022-31. residential aged care facilities. Human Reproduction Update 2010. doi:10.1093/humupd/dmq045. Heng S, Paule S, Hardman B, Li Y, Hardy CL, Lemasurier JS, Olsson F, Dang Singh H, Rainczuk A, Stephens AN, Hawker JA, Walker KZ, Barrington V, T, Yao J, Yang M, Plebanski M, Phillips Nie G. Posttranslational activation Andrianopoulos N. Measuring the DJ, Mollard R, Rolland JM, O’Hehir RE. of bone morphogenetic protein 2 is success of an objective structured Interleukin-13 regulates secretion of mediated by proprotein convertase 6 clinical examination for dietetic the tumor growth factor-β superfamily during decidualization for pregnancy students. J Hum Nutr Diet. 2010 cytokine activin A in allergic airway establishment. Endocrinology Jun;23(3):212-6. inflammation.Am J Respir Cell Mol Biol. 2010;151:3909-3917. 2010;42(6):667-75.
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Herlihy AS, Halliday J, McLachlan RI, Hoare B, Wallen M, Imms C, Villanueva E, Holmes NE, Iles LE, Danks RA, Korman Cock M, Gillam L. Assessing the risks Rawicki HB, Carey L. (2010). Botulinum TM. Neurocysticercosis causing and benefits of diagnosing genetic toxin A as an adjunct to treatment in sudden death. Am J Forensic Med conditions with variable phenotypes the management of the upper limb Pathol. 2010 Jun;31(2):117-9. through population screening: in children with spastic hemiplegic Klinefelter syndrome as an example. cerebral palsy: Update. Cochrane Holmes NE, Opat S, Kelman A, Korman J Community Genet. 2010;1(1):41-46. Database of Systematic Reviews, TM. Refractory Bartonella quintana Issue 1. bacillary angiomatosis following Hermansen I, O’Connell B, Gaskin CJ. chemotherapy for chronic lymphocytic Are Postpartum Women in Denmark Hoare, B., Imms, C., Rawicki, H. B., leukaemia. J Med Microbiol. 2011 Being Given Helpful Information About Carey, L. (2010). Modified Jan;60(Pt 1):142-6. Epub 2010 Oct 14. Urinary Incontinence and Pelvic Floor constraint-induced movement therapy Exercises? Journal of Midwifery & or bimanual occupational therapy Hong MKH, Kong J, Namdarian B, Women’s Health 2010; 55(2):171-4. following injection of Botulinum toxin-A Longano A, Grummet J, Hovens to improve bimanual performance in CM, Costello AJ, Corcoran NM. Hermansen IL, O’Connell B, Gaskin CJ. children with hemiplegic cerebral palsy: Paraneoplastic Syndromes in Prostate Women’s Explanations for Urinary A randomised controlled trial methods Cancer. Nature Reviews Urology Incontinence, Their Management paper. Biomedical Central Neurology, 2010;7:681-692. Strategies, and Their Quality of Life 10(58). during the Postnatal Period. Journal Hope N, Rombauts L. Can an educational of Wound, Ostomy & Continence Hocking DR, McGinley JL, Moss SA, DVD improve the acceptability of Nursing 2010; 37(2):187-92. Bradshaw JL, & Rinehart NJ. Effects elective single embryo transfer? of external and internal cues on gait A randomized controlled study. Hewagama S, Walker SP, Stuart RL, functioning in Williams Syndrome. Fertil Steril. 2010 Jul;94(2):489-495. Gordon C, Johnson PD, Friedman Journal of Neurological Sciences, Horne RS, Witcombe NB, Yiallourou ND, O’Reilly M, Cheng AC, Giles ML. 2010;291(1-2), 57-63. doi: 10.1016/j. SR, Richardson HL. Sudden Infant 2009 H1N1 influenza A and pregnancy jns.2009.12.026 outcomes in Victoria, Australia. Clin Death Syndrome: implications of Infect Dis. 2010 Mar 1;50(5):686-90. Hocking, D.R., Fielding, J., Corben, L.A., altered physiological control during Cremer, P.D., Millist, L., White, O.B., sleep. Current Pediatric Reviews. Hickey MJ, Malone CC, Erickson KL, Delatycki, M.B. (2010). Ocular motor 2010;6(1):30-8. Jadus MR, Prins RM, Liau LM, Kruse fixation deficits in Friedreich ataxia. Horne RS, Witcombe NB, Yiallourou CA. Cellular and vaccine therapeutic Cerebellum, 9 (3):411-418. approaches for gliomas. J Transl Med. SR, Scaillet S, Thiriez G, Franco P. 2010;8:100. Hodges R, Salvador L, D’Antona D, Cardiovascular control during sleep Georgiou HM, Wallace EM. Activin in infants: implications for Sudden Hill A, Hoffman T, Hill K, Oliver D, Beer A as a marker of intrauterine infection Infant Death Syndrome. Sleep Med. C, McPhail S, Brauer S, Haines T. in women with preterm prelabour 2010;11(7):615-21. Measuring falls incidence in acute rupture of membranes. J Perinatol. Hough JP, Boyd RN and Keating JL. hospitals – A comparison of three 2010 Jan;30(1):22-6. reporting methods to identify missing Systematic review of interventions data in the hospital reporting system. Holden CA, Allan CA, McLachlan RI. for low bone mineral density in Journal of the American Geriatrics ‘Male friendly’ services: A matter of children with cerebral palsy. Pediatrics Society. 2010; 58: (7) 1347-1352. semantics. Australian Family Physician 2010:125;e-670-678. 2010; 39(1/2): 9-10. Hillman NH, Kallapur SG, Pillow JJ, Moss Hubbard SA, Gargett CE. A cancer stem TJ, Polglase GR, Nitsos I, Jobe AH. Holden CA, Allan CA, McLachlan RI. cell origin for human endometrial Airway injury from initiating ventilation Windows of Opportunity: A holistic carcinoma? Reproduction. in preterm sheep. Pediatr Res. approach to men’s health. Medical 2010;140(1):23-32. 2010;67(1):60-5. Journal of Australia 2010 Jun Hutchison SK, Stepto NK, Harrison CL, 21;192(12):708-711. Hillman NH, Kallapur SG, Pillow JJ, Nitsos Moran LJ, Strauss BJ, Teede HJ. I, Polglase GR, Ikegami M, Jobe Holden CA, McLachlan RI, Pitts M, Effects of exercise on insulin AH. Inhibitors of inflammation and Cumming R, Wittert G, Ehsani JP, resistance and body composition in endogenous surfactant pool size as de Kretser DM, Handelsman DJ. overweight and obese women with modulators of lung injury with initiation Determinants of male reproductive and without polycystic ovary syndrome. of ventilation in preterm sheep. health disorders: the Men in Australia J Clin Endocrinol Metab. 2011 Jan; Respir Res. 2010;11:151. Telephone Survey (MATeS). BMC 96(1):E48-56. Public Health. 2010;10(1):96.
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Hutton ML, Kaparakis-Liaskos M, Turner Jackson K, Ashby M, Howell D, Petersen Jaremko JL, Jans LB, Coleman LT, L, Cardona A, Kwok T, Ferrero RL. J, Brumley D, Good P, Pisasale M, Ditchfield MR. Value and limitations Helicobacter pylori exploits cholesterol- Wein S, Woodruff R. The effectiveness of DWI in grading and diagnosis of rich microdomains for induction of and adverse effects profile of “Burst” pediatric posterior fossa tumors. NF-kappaB-dependent responses and Ketamine in refractory cancer pain: AJNR 2010, 9:1613-6. peptidoglycan delivery in epithelial The VCOG PM 1-00 Study. Journal of cells. Infect Immun. 2010;78(11): Palliative Medicine 2010. 26(3);176-183. Jarvis EM, Hawley CM, McDonald SP, 4523-31. Brown FG, Rosman JB, Wiggins Jain AK, Lotan C, Meredith IT, Feres F, KJ, Bannister KM, Johnson DW. Ierino F, Boudville N, Kanellis J. The Zambahari R, Sinha N, Rothman MT. Predictors, treatment and outcomes CARI guidelines. Donors at risk: Twelve-month outcomes in patients of non-Pseudomonas Gram negative hypertension. Nephrology, 15 (S1): with diabetes implanted with a peritonitis. Kidney Int. 2010; 78(4): S114-S120, 2010. zotarolimus-eluting stent: results from 408-14. the E-Five Registry. Heart. 2010 Ierino F, Kanellis J. The CARI guidelines. Jun;96(11):848-53. Jefferson AL, Woodhead HJ, Fyfe S, Donors at risk: haematuria. Briody J, Bebbington A, Strauss BJ, Nephrology 2010;15 (S1): S111-S113. James A, Williams C, Haines T. Heel Jacoby P, Leonard H. Bone mineral raises versus prefabricated orthoses content and density in Rett syndrome Ierino FL, Mulley W, Dodge N, Li YQ, in the treatment of posterior heel pain and their contributing factors. Pediatr Mouhtouris E, Christiansen D, Sandrin associated with calcaneal apophysitis Res. 2010 Dec 20. MS. Dendritic cells expressing soluble (Sever’s disease): a randomised control CTLA4Ig prolong antigen-specific trial. The Journal of Foot and Ankle Jenkins A, Krishnamurthy B, Best J, skin graft survival. Immunol Cell Biol. Research. 2010;3:3. Cameron F, Colman P, Hamblin P, 2010; 88(8):846-50. O’Connell M, Rodda C, Teede H, Jamieson S, Bützow R, Andersson Rowley K, O’Neal D. Evaluation of an Ikezumi Y, Suzuki T, Karasawa T, Hasegawa N, Alexiadis M, Unkila-Kallio L, algorithm to guide patients with type H, Imai N, Ueno M, Narita I, Kawachi Heikinheimo M, Fuller PJ. and Anttonen 1 diabetes treated with continuous H, Nikolic-Paterson DJ, Uchiyama M: M. The FOXL2 C134W mutation is subcutaneous insulin infusion (CSII) on Identification of alternatively activated characteristic of adult granulosa cell how to respond to real-time continuous macrophages in new onset pediatric tumors of the ovary: independent glucose levels – a randomised trial. and adult IgA nephropathy; correlation confirmation from two centers. Diabetes Care 2010;3(6):1242-1248. with mesangial matrix expansion. Modern Pathology 2010; 23:1477-85. Histopathology (in press, accepted Jenkins KA, Mansell A. TIR-containing 23/3/10) Jans L, Ditchfield M, Gomez L, et al. adaptors in Toll-like receptor signalling. MR imaging findings of haemophilic Cytokine. 2010;49(3):237-44. Ikezumi Y, Suzuki T, Karasawa T, Hasegawa arthropathy of the elbow in children. H, Kawachi H, Nikolic-Paterson DJ, JBR-BTR, 2010, 93:247-251. Jette N, Quan H, Hemmelgarn B, Drosler Uchiyama M. Contrasting effects of S, Maass C, Moskal L, Paoin W, steroids and mizoribine on macrophage Jaques AM, Amor DJ, Baker HW, Healy DL, Sundararajan V, Gao S, Jakob R, activation and glomerular lesions Ukoumunne OC, Breheny S, Garrett Ustun B, Ghali WA. The development, in rat thy-1 mesangial proliferative C, Halliday JL. Adverse obstetric evolution, and modifications of ICD- glomerulonephritis. Am J Nephrol. and perinatal outcomes in subfertile 10: challenges to the international 2010;31(3):273-82. women conceiving without assisted comparability of morbidity data. reproductive technologies. Fertil Steril. Med Care. 2010 Dec;48(12):1105-10. Inda MM, Bonavia R, Mukasa A, 2010 Dec;94(7):2674-9. Narita Y, Sah DW, Vandenberg S, Jin Y, Calvert TJ, Chen B, Chicoine LG, Brennan C, Johns TG, Bachoo Jardine MJ, Ninomiya T, Perkovic V, Cass Joshi M, Bauer JA, Liu Y, Nelin LD. R, Hadwiger P, Tan P, Depinho A, Turnbull F, Gallagher MP, Zoungas Mice deficient in Mkp-1 develop more RA, Cavenee W, Furnari F. Tumor S, Lambers Heerspink HJ, Chalmers severe pulmonary hypertension and heterogeneity is an active process J, Zanchetti A. Aspirin is beneficial greater lung protein levels of arginase maintained by a mutant EGFR-induced in hypertensive patients with chronic in response to chronic hypoxia. cytokine circuit in glioblastoma. kidney disease: a post-hoc subgroup Am J Physiol Heart Circ Physiol. Genes Dev. 2010;24(16):1731-45. analysis of a randomized controlled 2010;298(5):H1518-28. trial. Journal of American College of Ioannou L, Massie J, Lewis S, Petrou Cardiology. 2010 Sep 14;56(12):956-65. V, Gason A, Metcalfe S, Aitken MA, Bankier A, Delatycki MB. Evaluation of a multi-disease carrier screening programme in Ashkenazi Jewish high schools. Clin Genet. 2010 Jul;78(1): 21-31.
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Johns TG, McKay MJ, Cvrljevic AN, Gan Jun M, Zoungas S, Perkovic V, Webster AC. Kee K, Sands SA, Edwards BA, Berger PJ, HK, Taylor C, Xu H, Smyth FE, Scott How to read a report of a randomized Naughton MT. Positive airway pressure AM. MAb 806 enhances the efficacy of controlled trial. Nephrology (Carlton). in congesitve heart failure. Sleep ionizing radiation in glioma xenografts 2010 Mar;15(2):153-7. Medicine Clinics. 2010;6(3):393-405. expressing the de2-7 epidermal growth factor receptor. Int J Radiat Oncol Biol Kaitu’u-Lino TJ, Ye L, Gargett CE. Kelly RD, St John JC. Role of mitochondrial Phys. 2010;78(2):572-8. Reepithelialization of the uterine DNA replication during differentiation surface arises from endometrial of reprogrammed stem cells. Int J Dev Johnson DW, Cho Y, Livingston BE, glands: evidence from a functional Biol. 2010;54(11-12):1659-70. Hawley CM, McDonald SP, Brown FG, mouse model of breakdown and repair. Rosman JB, Bannister KM, Wiggins Endocrinology. 2010;151(7):3386-95. Kempster PA, O’Sullivan SS, Holton JL, KJ. Encapsulating peritoneal sclerosis: Revesz T, Lees AJ. Relationships incidence, predictors and outcomes. Kam JK, Cooray SD, Kam JK, Smith JA, between age and late progression Kidney Int. 2010 May;77(10):904-12. Almeida AA. A cost-analysis study of Parkinson’s disease: a of robotic versus conventional mitral clinico-pathological study. Brain. Johnson DW, Clarke M, Wilson V, Woods F, valve repair in Australia. Heart Lung 2010 Jun;133(Pt 6):1755-62. Brown FG. Rationale and design of the Circulation 2010;19:413-418. balANZ trial: a randomised controlled Kengne AP, Patel A, Colagiuri S, Heller S, trial of low GDP, neutral pH versus Kanellis J, Ma FY, Kandane-Rathnayake Hamet P, Marre M, Pan CY, Zoungas standard peritoneal dialysis solution R, Dowling JP, Polkinghorne KR, S, Grobbee DE, Neal B, Chalmers J, for the preservation of residual renal Bennett BL, Friedman GC, Nikolic- Woodward M; ADVANCE Collaborative function. BMC Nephrology 2010 Sept Paterson DJ. JNK signalling in human Group. The Framingham and UK 16 11:25 and experimental renal ischaemia/ Prospective Diabetes Study (UKPDS) reperfusion injury. Nephrol Dialysis risk equations do not reliably estimate Johnson DW, Hawley CM, McDonald SP, Transplant 2010;25:2898-2908. the probability of cardiovascular events Brown FG, Rosman JB, Wiggins KJ, in a large ethnically diverse sample Bannister KM, Badve SV. Superior Kanellis J. The CARI guidelines. of patients with diabetes: the Action survival of high transporters treated Justification for living donor kidney in Diabetes and Vascular Disease: with automated versus continuous transplantation. Nephrology, 15 Preterax and Diamicron-MR Controlled ambulatory peritoneal dialysis. Nephrol (S1): S72-S79, 2010. Evaluation (ADVANCE) Study. Dial Transplant 2010; 25(6):1973-9. Diabetologia. 2010 May;53(5):821-31. Kaparakis M, Turnbull L, Carneiro L, Jones B, Ditchfield M, Cahoon G, et al. Firth S, Coleman HA, Parkington Kerr PG, Huang L. Review: membranes Cardiac MRI prior to bidirectional HC, Le Bourhis L, Karrar A, Viala J, for haemodialysis. Nephrology cavopulmonary connection in Mak J, Hutton ML, Davies JK, Crack (Carlton). 2010 Jun;15(4):381-5. hypoplastic left heart syndrome. Heart, PJ, Hertzog PJ, Philpott DJ, Girardin Lung & Circulation. Online 7/5/2010. SE, Whitchurch CB, Ferrero RL. King PT, Daviskas E. The pathogenesis Bacterial membrane vesicles deliver and diagnosis of bronchiectasis. Jones KL, Roche M, Gantier MP, Begum peptidoglycan to NOD1 in epithelial Breathe; 2010; 6:353-60 NA, Honjo T, Caradonna S, Williams cells. Cell Microbiol. 2010;12(3):372-85. BRG, Mak J. X4 and R5 HIV-1 have King PT, Daviskas, E. The management of distinct post-entry requirements Karapetis CS, Cheong KA, Yip D, bronchiectasis. Breathe 2010; 6;343-52 for uracil DNA glycosylase during Strickland AH, Steer C, Marx G, King PT, Holdsworth SR, Freeezer NJ, infection of primary cells. J Biol Chem. Chrystal K, Harper PG. A phase I and Farmer MW, Villaneuva E, Holmes PW. 2010;285(24):18603-14. II trial of epirubicin, cisplatin, 24-hour infusion 5 fluorouracil and sodium Longitudinal study of lung diffusing Jones P, Leder K, Woolley I, Cameron P, folinate in patients with advanced capacity in bronchiectasis. Respiratory Cheng A, Spelman D. Postsplenectomy esophagogastric carcinomas. Care 2010; 55: 1667-75 infection - strategies for prevention in Asia- Pacific Journal of Clinical King PT, Holdsworth SR, Freezer NJ, general practice. Aust Fam Physician. Oncology 2010; 6:298-305. Villanueva E, Farmer MW, Guy 2010 Jun;39(6):383-6. Kave B, Yii M, Bell R, Kanellis J, Scott P, Holmes PW. Lung diffusing Joosten S, MacDonald M, Lau K, Bardin D, Saunder A. Initial Australasian capacity in adult bronchiectasis: a P, Hamilton G. Excessive dynamic experience with portal-enteric drainage longitudinal study. Respir Care. 2010 airway collapse co-morbid with COPD in simultaneous pancreas-kidney Dec;55(12):1686-92. diagnosed using 320-slice dynamic transplantation. ANZ J Surg. 2010 King PT. The pathogenesis of CT scanning technology. Thorax (online Oct;80(10):722-7. bronchiectasis. Paediatr. Respir. Rev. first doi:10.1136/thx.2009.132035) (2010), doi:10.1016/j.prrv.2010.10.011 Epub 7 July 2010.
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King SJ, Nyulasi IB, Strauss BJ, Kotsimbos Kolosov A, Goodchild CS, Cooke I. Kvansakul M, Wei A, Fletcher J, Willis S, T, Bailey M, Wilson JW. Fat-free mass CNSB004 (Leconotide) causes Chen L, Roberts A, Huang D, Colman P. depletion in cystic fibrosis: associated antihyperalgesia without side Structural basis for apoptosis inhibition with lung disease severity but poorly effects when given intravenously: a by Epstein-Barr virus BHRF1. Accepted detected by body mass index. Nutrition. comparison with ziconotide in a rat for publication PLoS Pathology, 2010 Jul-Aug;26(7-8):753-9. model of diabetic neuropathic pain. November 2010. Pain Med. 2010;11(2):262-73. Kitchen MJ, Paganin DM, Uesugi K, Kyaw T, Tay C, Khan A, Dumouchel Allison BJ, Lewis RA, Hooper SB, Kolosov A, Goodchild CS, Cooke I. V, Cao A, To K, Kehry M, Dunn R, Pavlov KM. X-ray phase, absorption Studies of synergy between morphine Agrotis A, Tipping P, Bobik A, Toh and scatter retrieval using two or more and a novel sodium channel BH. Conventional B2 B cell depletion phase contrast images. Opt Express. blocker, CNSB002, in rat models of ameliorates whereas its adoptive 2010;18(19):19994-20012. inflammatory and neuropathic pain. transfer aggravates atherosclerosis. Pain Med. 2010;11(1):106-18. J Immunol. 2010 Oct 1;185(7):4410-9. Kitson M, Roberts S, Kemp W, Iser D, Street A, Tran HAM. The prevalence Koskimaki JE, Karagiannis ED, Tang Lai NM, Foong SC, Foong WC, of significant liver fibrosis and cirrhosis BC, Hammers H, Watkins DN, Pili R, Tan K. Co-bedding in neonatal in haemophilia patients infected Popel AS. Pentastatin-1, a collagen IV nursery for promoting growth and with hepatitis C using Fibroscan. derived 20-mer peptide, suppresses neurodevelopment in stable preterm Haemophilia. 2010 Oct 28. [Epub tumor growth in a small cell lung twins (Protocol). Cochrane Database ahead of print]. cancer xenograft model. BMC Cancer. of Systematic Reviews 2010; 2010;10:29(29):1-7. Issue 1. Art. No.: CD008313. DOI: Kitto S. Evidence-based checklists: 10.1002/14651858.CD008313. intended and unintended Kotsanas D, Robbins J, Awad MM, consequences for interprofessional Lyras D, Rood JR, Jenkin G, Stuart RL, Lambers Heerspink HJ, Ninomiya T, care. J Interprof Care. 2010 Korman TM. The novel use of tryptose Perkovic V, Woodward M, Zoungas Nov;24(6):609-11. sulfite cycloserine egg yolk agar for S, Cass A, Cooper M, Grobbee isolation of Clostridium perfringens DE, Mancia G, Mogensen CE, Neal Kitto SC, Petrovic A, Gruen RL, Smith JA. during an outbreak of necrotising B, Chalmers J; for the ADVANCE Evidence based medicine training and enterocolitis in a neonatal unit. Journal Collaborative Group. Effects of a implementation in surgical practice: of Clin Micro. 2010: 48; 4263-65 fixed combination of perindopril and the role of surgical cultures. Journal indapamide in patients with type 2 of Evaluation in Clinical Practice 2010 Kulkarni J, De Castella A, Headey B, diabetes and chronic kidney disease. (In press; accepted 28/5/10; Epub Marston N, Sinclair K, Lee S, Gurvich C, European Heart Journal. 2010 May 25. Aug 2010). Fitzgerald PB, Burger H. Estrogens and doi: 10.1093/eurheartj/ehq139. men with schizophrenia: Is there a case Knower KC, To SQ, Simpson ER, Clyne for adjunctive therapy? Schizophr Res Le STT, Lee SSK, Prideaux L, Block AA, CD. Epigenetic mechanisms regulating 2010 (Nov 8). Moore GTC. Primary cytomegalovirus CYP19 transcription in human breast ileitis complicated by massive adipose fibroblasts. Molecular and Kumar A, Lakkundi A, McNamara PJ, gastrointestinal haemorrhage in Cellular Endocrinology 2010;321: Sehgal A. Surfactant and patent ductus a patient with steroid refractory 123-130 arteriosus. Indian J Pediatr 2010; Crohn’s disease. Intern Med J. Jan;77(1):51-5. Epub 2010 Jan 20. 2010 Nov;40(11):788-91. Ko HJ, Chung JY, Nasa Z, Chan J, Siatskas C, Toh BH, Alderuccio F. Targeting Kung PP, Huang B, Zhang G, Zhou JZ, Lee FT, O’Keefe GJ, Gan HK, Mountain MOG expression to dendritic Wang J, Digits JA, Skaptason J, AJ, Jones GR, Saunder TH, Sagona J, cells delays onset of experimental Yamazaki S, Neul D, Zientek M, Elleraas Rigopoulos A, Smyth FE, Johns TG, autoimmune disease. Autoimmunity. J, Mehta P, Yin MJ, Hickey MJ, Gajiwala Govindan SV, Goldenberg DM, Old LJ, 2010 Oct 1. KS, Rodgers C, Davies JF, Gehring MR. Scott AM. Immuno-PET quantitation Dihydroxyphenylisoindoline amides as of de2-7 epidermal growth factor Ko HJ, Kinkel SA, Hubert FX, Nasa Z, orally bioavailable inhibitors of the heat receptor expression in glioma using Chan J, Siatskas C, Hirubalan P, shock protein 90 (hsp90) molecular 124I-IMP-R4-labeled antibody ch806. Toh BH, Scott HS, Alderuccio F. chaperone. J Med Chem. 2010 Jan J Nucl Med. 2010;51(6):967-72. Transplantation of autoimmune 14;53(1):499-503. regulator-encoding bone marrow Lee J, Shekelton P, Kimber C, Cheng W. cells delays the onset of experimental Severe Fetal Megacystis. ANZ J Surg autoimmune encephalomyelitis. Eur 2010, (Epub). J Immunol. 2010 Sep 21.
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Lee JH, Palermo C, Bryce A, McCarten Li Y, Puryer M, Lin E, Hale K, Salamonsen Lombard C, Deeks A, Jolley D, Ball K, J. Process evaluation of community LA, Manuelpillai U, Tong S, Chan W, Teede H. A low-intensity community kitchens: Results from two Victorian Wallace EM, Nie G. Placental HtrA3 lifestyle programme to prevent weight local government areas. Health Promot Is Regulated by Oxygen Tension and gain in women with young children: J Austr. 2010 Dec;21(3):183-8. Serum Levels Are Altered during Cluster randomised controlled trial. Early Pregnancy in Women Destined British Medical Journal 2010 Jul Lee JH, Peters A, Fisher P, Bowles EJ, to Develop Preeclampsia. J Clin 13;341:c3215. doi:10.1136/bmj c3215. St John JC, Campbell KH. Generation Endocrinol Metab. 2011 Feb;96(2): of mtDNA homoplasmic cloned lambs. 403-11. Longano A, Beech P, Nelva P. p16 staining Cell Reprogram. 2010;12(3):347-55. of subcutaneous smooth muscle Lickliter JD, Francesconi AB, Smith G, tumours. Pathology 2010; 42:173-174. Lee YC, Phan TG, Jolley DJ, Castley HC, Burge M, Coulthard A, Rose S, Griffin Ingram DA, Reutens DC. Accuracy M, Milne R, McCarron J, Yeadon T, Longano A, Conyers R. Medulloblastoma of clinical signs, SEP, and EEG in Wilks A, Cubitt A, Wyld DK, Vasey arising from intracranial immature predicting outcome of hypoxic coma: PA. Phase I trial of CYT997, a novel teratoma. Pathology 2010;42:102-104. a meta-analysis. Neurology. 2010 cytotoxic and vascular-disrupting Lu ZX, Walker KZ, O’Dea K, Sikaris KA, Feb 16;74(7):572-80. agent. British Journal of Cancer 2010; Shaw J. HbA1c for Screening and 103: 597-606. Lemoh CN, Baho S, Grierson J, Hellard M, Diagnosis of Type 2 Diabetes in Routine Street A, Biggs BA. African Australians Liew M, Chan A.M, Galloway S, Comin Clinical Practice. Diabetes Care 2010; living with HIV: a case series from G, Flaim B, Prince H.M, Quach H. 33: 817-9. Victoria. Sex Health. 2010 Jun;7(2): Extra-Nasal NK/T Cell Lymphoma Lucas M, Nicol P, McKinnon E, Whidborne 142-8. Masquerading As Renal Infarction R, Lucas A, Thambiran A, Burgner D, [case report]. Leuk Lymphoma 2010; Lemon JM, Gargaro B, Enticott PG, and Waring J, French M. A prospective 51(6):1139-41. Rinehart NJ. Executive Functioning in large-scale study of methods for the Autism Spectrum Disorders: A Gender Liew SH, Drummond AE, Jones ME, detection of latent Mycobacterium Comparison of Response Inhibition. Findlay JK. The lack of estrogen tuberculosis infection in refugee J Autism Dev Disord 2011;41(3):352-356 and excess luteinizing hormone are children. Thorax 2010;65(5):442-8. responsible for the female ArKO mouse Leonard JM, Cozens AL, Reid SM, Ly JV, Donnan GA, Villemagne VL, Zavala phenotype. Molecular and Cellular Fahey MC, Ditchfield MR, Reddihough JA, Ma H, O’Keefe G, Gong SJ, Endocrinology 2010;327:56-64 DS. The diagnostic implications of a Gunawan RM, Saunder T, Ackerman U, normal MRI scan in cerebral palsy. Lim AK, Ma FY, Nikolic-Paterson DJ, Tochon-Danguy H, Churilov L, Phan TG, Accepted Dev Med Child Neurol Kitching AR, Thomas MC, Tesch GH. Rowe CC. 11C-PIB binding is increased 2011;53: 226–232. Lymphocytes promote albuminuria, in patients with cerebral amyloid but not renal dysfunction or histological angiopathy-related hemorrhage. Li H, Simpson ER, Liu JP. Oestrogen, damage in a mouse model of diabetic Neurology. 2010 Feb 9;74(6):487-93. telomerase, ovarian ageing and cancer. renal injury. Diabetologia. 2010 Clinical and Experimental Pharmacology Ma FY, Ikezumi Y, Nikolic-Paterson DJ. Aug;53(8):1772-82. and Physiology 2010;37:78-82 Macrophage signaling pathways: a Lim YN, Dwyer P, Muller R, Rosamilia A, novel target in renal disease. Semin Li J, Qu X, Ricardo SD, Bertram JF, Lee J, Stav K. Do the Advantage slings Nephrol. 2010 May;30(3):334-44. Nikolic-Paterson DJ. Resveratrol work as well as the tension-free vaginal inhibits renal fibrosis in the obstructed Mahar P, Padiglione AA, Cleland H, Paul E, tapes? International Urogynecology kidney: potential role in deacetylation Hinrichs M, Wasiak J. Pseudomonas Journal Sept 2010, 21 (9): 1157-1162 of Smad3. Am J Pathol. 2010 aeruginosa bacteraemia in burns Sep;177(3):1065-71. Lin TL, Wang QH, Brown P, Peacock C, patients: Risk factors and outcomes. Merchant AA, Brennan S, Jones E, Burns. 2010 Dec;36(8):1228-33. Epub Li Q, Chalmers J, Czernichow S, Neal McGovern K, Watkins DN, Sakamoto 2010 Jun 9. B, Taylor BA, Zoungas S, Poulter N, KM, Matsui W. Self-renewal of acute Woodward M, Patel A, de Galan B, Makoutonina M, Iansek R, Simpson P. lymphocytic leukemia cells is limited Batty GD; ADVANCE Collaborative Optimizing care of residents with by the Hedgehog pathway inhibitors group. Oral disease and subsequent Parkinsonism in supervised facilities. cyclopamine and IPI-926. PLoS One. cardiovascular disease in people with Parkinsonism and Related Disorders 2010;5(12):e15262. type 2 diabetes: a prospective cohort 2010;16(5):351-55. study based on the Action in Diabetes Liu JP, Tang Y, Zhou S, Toh BH, McLean Malhotra A, Bajpai A, Hunt RW. Central and Vascular Disease: Preterax C, Li H. Cholesterol involvement in the Diabetes Insipidus in association with and Diamicron Modified-Release pathogenesis of neurodegenerative Neonatal Brain Abscess. J Pediatr Controlled Evaluation (ADVANCE) trial. diseases. Mol Cell Neurosci. 2010 Endocrinol Metabol 2010; 23(3): Diabetologia. 2010 Nov;53(11):2320-7. Jan;43(1):33-42. 235-236.
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Malhotra A, Carse E. Survey of Markman B, Tabernero J. Monoclonal Matera JT, Egerton-Warburton D, Meek R. management of neonatal haemolytic antibodies in solid tumours. Curr Clin Ultrasound guidance for central venous jaundice in Australasia. J Paediatr Pharmacol. 2010;5(3):160-5. catheter placement in Australasian Child Health 2010; 46(5): 222-225. emergency departments: Potential Marmor GO, Braitberg G, Nicolas C. barriers to more widespread use. Malhotra A, Hunt RW, Doherty RR. Medication and therapeutic errors in Emerg Med Australas. 2010; Streptococcus pneumoniae sepsis in emergency departments (MATED): 22:514-23.emm the newborn. J Paediatr Child Health. A survey of medication prescribing, 2010 Epub Dec 29. surveillance and safety issues in Maydan M, McDonald PC, Sanghera J, Australasian emergency departments. Yan J, Rallis C, Pinchin S, Hannigan GE, Malhotra A, Lakkundi A, Carse E. Bilious Journal of Pharmacy Practice and Foster LJ, Ish-Horowicz D, Walsh MP, vomiting in the newborn: 6 year data Research. 2010 (in press). Dedhar S. Integrin-linked kinase from a Level III Centre. J Paediatr is a functional Mn2+-dependent Child Health 2010; 46(5):259-261. Marom, L. Insulin pump access issues protein kinase that regulates for visually impaired people with type glycogen synthase kinase-3beta Malhotra A, Menahem S, Gillam L. 1 diabetes. Diabetes Res Clin Pract. (GSK-3beta) phosphorylation. Ethical Issues in Fetal Management – 2010 Jul;89(1):e13-5. doi: 10.1016/j. PLoS One. 2010;5(8):e12356. A Cardiac Perspective. Int J Pediatr diabres.2010.04.005. 2010; 857460. Epub 2010 Mar 24. McAfee AJ, McSorley EM, Cuskelly GJ, Martin A, Amin J, Cooper DA, Carr A, Moss BW, Wallace JM, Bonham MP, Malhotra A. Nanocrystalline silver dressing Kelleher AD, Bloch M, Baker D, Woolley Fearon AM. Red meat consumption: in the initial management of a giant I, Emery S; on behalf of the STEAL an overview of the risks and benefits. omphalocele. J Paediatr Child Health study group. Abacavir does not affect Meat Sci. 2010 Jan;84(1):1-13. 2010; 46(6): 365-366. circulating levels of inflammatory or coagulopathic biomarkers in McCabe MP, Ricciardelli LA, & Holt K. Mansour D, Mommers E, Teede H, suppressed HIV: a randomized clinical Are there different sociocultural Sollie-Eriksen B, Graesslin O, Ahrendt trial. AIDS. 2010 Nov 13;24(17): influences on body image and body HJ, Gemzell-Danielsson K. Clinician 2657-63. change strategies for overweight satisfaction and insertion characteristics adolescent boys and girls? Eating of an innovative new applicator to Martin CA, Cameron JD, Chen SS, Behaviors, 2010:11;156-163. insert radiopaque implanon: An McGrath BP. Measurement of blood open-label, non-controlled, multicenter pressure in the office. Hypertension. McCabe MJ, Tarulli GA, Meachem SJ, trial. Contraception 2010;82(3):243-249. 2010 Jul;56(1):e11; author reply e2. Robertson DM, Smooker PM, Stanton PG 2010 Gonadotropins regulate Manuelpillai U, Tchongue J, Lourensz D, Martin CA, Cameron JD, Chen SS, rat testicular tight junctions in vivo. Vaghjiani V, Samuel CS, Liu A, Williams McGrath BP. Two hour glucose post Endocrinology 151:2911-2922 ED, Sievert W. Transplantation of loading: a biomarker of cardiovascular human amnion epithelial cells reduces risk in patients with isolated clinic McGregor NE, Poulton IJ, Walker EC, hepatic fibrosis in immunocompetent hypertension. J Hypertens 2010 Pompolo S, Quinn JM, Martin TJ, CCl4-treated mice. Cell Transplant. (epub ahead of print 29.12.2010). Sims NA. Ciliary neurotrophic factor 2010;19(9):1157-68. inhibits bone formation and plays Martin PR. Managing headache triggers: a sex-specific role in bone growth Mariasegaram M, Tesch GH, Verhardt S, Think ‘coping’ not ‘avoidance’. and remodeling. Calcified Tissue Hurst L, Lan HY, Nikolic-Paterson DJ. Cephalalgia. May 2010; 30(5):634-637. International 2010;86:261-270 Lefty antagonises TGF-β1 induced epithelial-mesenchymal transition Martin TJ, Allan EH, Ho PW, Gooi JH, McKenzie DP, Clarke DM, Forbes AB, in tubular epithelial cells. Biochem Quinn JM, Gillespie MT, Krasnoperov Sim MR. Pessimism, worthlessness, Biophys Res Commun. 2010; 393: V, Sims NA. Communication between anhedonia and thoughts of death 855-9. EphrinB2 and EphB4 within the identify DSM-IV major depression osteoblast lineage. Advances in in hospitalised medically ill. Markman B, Dienstmann R, Tabernero J. Experimental Medicine and Biology Psychosomatics 2010 51: 302-311. Targeting the PI3K/Akt/mTOR pathway 2010;658:51-60 - beyond rapalogs. OncoTarget. McKenzie M, Clarke DM, McKenzie DP, 2010;1(7):530-43. Matalon S, Palmer BE, Nold MF, Furlan Smith GC. Which factors predict the A, Kassu A, Fossati G, Mascagni P, persistence of DSM-IV depression, Markman B, Rodriguez-Freixinos Dinarello CA. The histone deacetylase anxiety and somatoform disorders V, Tabernero J. Biomarkers in inhibitor ITF2357 decreases surface in the medically ill three months post colorectal cancer. Clin Transl Oncol. expression of CXCR4 and CCR5 on discharge. Journal of Psychosomatic 2010;12(4):261-70. CD4+ T-cells and monocytes and is Research 2010; 68: 21-28. superior to valproic acid for latent HIV-1 expression in vitro. J Acquir Immune Defic Syndr Mai 2010;54(1):1-9.
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McLachlan R, Kovacs GT, Cook RG. Meehan KL, Rainczuk A, Salamonsen Merriman E, Nandurkar D, Opat S, Tran The role of the GP in managing LA, Stephens AN. Proteomics and H.A Case of ITP with Cauda Equina male infertility. Medicine Today. the search for biomarkers of female Syndrome. Annals of Haematology. 2010;11(10):16-26. reproductive diseases. Reproduction 2010 Sep 18. [Epub ahead of print] 2010;140:505-519 McLachlan RI. Certainly more guidelines Milne O, Cutts B, McLean C, Gin than rules. J Clin Endocrinol Metab. Meek R, Sullivan A, Favilla M, Larmour I, D. Palifermin-induced acral 2010;95(6):2610-3. Guastalegname S. Is homatropine 5% erythrodysaesthesia variant in the effective in reducing pain associated treatment of acute myeloid leukaemia. McLachlan RI, O’Bryan MK. State of the with corneal abrasion when compared J Austral Dermatol. 2010. art for genetic testing of infertile men. with placebo? A randomized Journal of Clinical Endocrinology & controlled trial. Emerg Med Australas Minden M, Wei A. Revisiting late relapses Metabolism 2010;95:1013-1024 2010;22(6):507-513. in acute myeloid leukemia. Leukemia & Lymphoma. 2010; 51(5):735-736. McLean G, Menahem S, Teoh M. Prenatal Meek RA, Nicolas C, Mahendraraviraj NA. diagnosis of cor triatriatum dexter. Primary care patients in the Emergency Mithraprabhu S, Grigoriadis G, Khong T, Ultrasound Obstet Gynecol 36:777. Department: Reasons for attendance Spencer A. Deacetylase inhibition in and influences on likelihood to return. myeloproliferative neoplasms. Invest McMahon LP, Kent AB, Kerr PG, Healy The Medical Journal of Australia. 2010 New Drugs. 2010 (In Press). H, Irish AB, Cooper B, Kark A, Roger (in press). SD. Maintenance of elevated versus Mithraprabhu S, Mendis S, Meachem physiological iron indices in non- Mejias-Luque R, Linden SK, Garrido SJ, Tubino L, Matzuk MM, Brown CW, anaemic patients with chronic kidney M, Tye H, Najdovska M, Jenkins BJ, Loveland KL. Activin bioactivity affects disease: a randomized controlled Iglesias M, Ernst M, de Bolos C. germ cell differentiation in the postnatal trial. Nephrol Dial Transplant. 2010 Inflammation modulates the expression mouse testis in vivo. Biol Reprod. Mar;25(3):920-6. of the intestinal mucins MUC2 and 2010;82(5):980-90. MUC4 in gastric tumors. Oncogene. McNamara PJ, Stewart L, Sandesh S, Mockler JC. Professional ethics in 2010;29(12):1753-62. Sehgal A, Stephens D, Redington midwifery practice. British Journal of A. PDA ligation is associated with Menahem S. Respiratory syncytial virus Midwifery. 2010;18(8):541. Postoperative Myocardial Dysfunction and complete heart block in a child. Mockler JC, Murphy DJ, Wallace EM. An in Premature infants. J Thorac Cardiology in the Young 2010; 20: Australian and New Zealand survey Cardiovasc Surg 2010 140(1):150-7. 103-104. of practice of the use of oxytocin at McNamara PJ, Stewart L, Shivananda Menkhorst E, Salamonsen LA, Zhang elective caesarean section. Aust N Z J SP, Stephens D, Sehgal A. Patent J, Harrison CA, Gu J, Dimitriadis E. Obstet Gynaecol. 2010 Feb;50(1):30-5. ductus arteriosus ligation is associated Interleukin 11 and activin A synergise Monagle J, Shearer B, Loughnan with impaired left ventricular systolic to regulate progesterone-induced but T. Operating Room Efficiency: a performance in premature infants not cAMP-induced decidualization. discussion of issues and strategies for weighing less than 1000 g. J Thorac Journal of Reproductive Immunology improvement. Asia Pacific Journal of Cardiovasc Surg 2010; Apr 2. 2010;84:124-132 [Epub ahead of print]. Health Management. 2010;5(2):30-35. Meredith IT, Worthley SG, Whitbourn R, Montag K, Gingold M, Boers A, Littlejohn G McPhail S, Comans T, Haines T. Evidence Walters D, McClean D, Ormiston J, O. DMARD usage, prescribing patterns of disagreement between patient Horrigan M, Wilkins GT, Hendriks R, and disease activity in community- perceived change and conventional Matsis P, Muller D, Cutlip DE. based practice. Int Med J 2010, epub longitudinal evaluation of change in Long-term clinical outcomes with the doi:10.1111/j.1445-5994.2010.02240. health-related quality of life among next-generation Resolute Stent System: older adults. Clinical Rehabilitation a report of the two-year follow-up Moodley Y, Ilancheran S, Samuel C, 2010;24(11): 1036-1044. from the RESOLUTE clinical trial. Vaghjiani V, Atienza D, Williams ED, EuroIntervention. 2010 Jan;5(6):692-7. McPhail S, Haines T. Response shift, Jenkin G, Wallace EM, Trounson A, Manuelpillai U. 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Moore EC, Padiglione AA, Wasiak J, Paul Murphy S, Rosli S, Acharya R, Mathias Newman L. Child abuse and neglect - E, Cleland H. Candida in burns: risk L, Lim R, Wallace EM, Jenkin G. counting the costs. Medicine Today, factors and outcomes. J Burn Care Res. Amnion epithelial cell isolation and 2010;11(4), 75-78. 2010 Mar-Apr;31(2):257-63. characterization for clinical use. Current Protocols in Stem Cell Biology Newton J, Jolly B, Ockerby C, Cross W. Moran L, Meyer C, Hutchison SK, Zoungas 2010 1E.6.1-1E.6.25 Clinical learning environment inventory: S, Teede HJ. Novel inflammatory Factor analysis. Journal of Advanced markers in overweight women with and Murphy, Brendan P. Beyond the first Nursing 2010: 66(6):1371-81. without polycystic ovary syndrome and episode: Candidate factors for a risk following pharmacological intervention. prediction model of schizophrenia. Ng H, McGinley JL, Jolley D, Morris M, Journal of Endocrinological Investigation International Review of Psychiatry. Workman B, Srikanth V. Effects of Apr 2010;33(4):258-265. 2010;22(2):202-223. footwear on gait and balance in people recovering from stroke. Age Ageing. Moran LJ, Gibson-Helm ME, Teede HJ, Naismith A, Skehan C, Nguyen Q. 2010 Jul;39(4):507-10. Deeks AA. Polycystic ovary syndrome: Cytology specimen preparation using A biopsychosocial understanding in Thin Prep – One year’s experience at Ngian G-S, Guymer E, Littlejohn G O. young women to improve knowledge Monash Medical Centre. Cytoletter The use of opioids in fibromyalgia. and treatment options. Journal 2010:34(4):4-7. Int J Rheum Dis 14(1):6-11, 2011. of Psychosomatic Obstetrics and Ngian G-S, Littlejohn G O. Is DISH Gynaecology 2010;31(1):24-31. Nakayama Y, Plisch EH, Sullivan J, Thomas C, Czuprynski CJ, Williams painful? J Rheumatol 37(9):1797-9 Moran LJ, Lombard CB, Lim S, Noakes M, BRG, Suresh M. Role of PKR and Type 2010[Editorial] Teede HJ. Polycystic ovary syndrome I IFNs in viral control during primary Nikolic-Paterson DJ. CD4+ T cells: and weight management. Women’s and secondary infection. PLoS Pathog. a potential player in renal fibrosis. Health 2010;6(2):271-83 2010;6(6):e1000966. Kidney Int. 2010 Aug;78(4):333-5. Moran LJ, Misso ML, Wild RA, Norman Nasis A, Leung MC, Antonis PR, Cameron Ninomiya T, Zoungas S, Neal B, Woodward RJ. Impaired glucose tolerance, type JD, Lehman SJ, Hope SA, Crossett MP, M, Patel A, Perkovic V, Cass A, Cooper 2 diabetes and metabolic syndrome Troupis JM, Meredith IT, Seneviratne M, Grobbee D, Hamet P, Harrap S, Liu in polycystic ovary syndrome: a SK. Diagnostic accuracy of noninvasive L, Mancia G, Mogensen CE, Poulter N, systematic review and meta-analysis. coronary angiography with 320-detector Rodgers A, Williams B, MacMahon S, Human Reproduction Update. 2010 row computed tomography. Am J Chalmers J; ADVANCE Collaborative Jul-Aug;16(4):347-63. Cardiol. 2010 Nov 15;106(10):1429-35. Group. Efficacy and safety of routine Moran LJ, Noakes M, Clifton PM, Norman Naughtin MJ, Sheffield DA, Rahman P, blood pressure lowering in older RJ. The effect of modifying dietary Hughes WE, Gurung R, Stow JL, patients with diabetes: results from the protein and carbohydrate in weight loss Nandurkar HH, Dyson JM, Mitchell ADVANCE trial. Journal of Hypertension. on arterial compliance and postprandial CA. The myotubularin phosphatase 2010 Jun;28(6):1141-9. lipidemia in overweight women with MTMR4 regulates sorting from early Nixon GM, Rodda C, Davey MJ. polycystic ovary syndrome. Fertility endosomes. J Cell Sci. 2010 Sep Longitudinal association between and Sterility. 2010 Nov;94(6):2451-4. 15;123(Pt 18):3071-83. Epub 2010 growth hormone therapy and Aug 24. Moro L, Arbini AA, Hsieh JT, Ford J, obstructive sleep apnoea in a child Simpson ER, Hajibeigi A, Oz OK. Neil PR, Wallace EM. Is Amnisure(R) with Prader Willi Syndrome. Journal Aromatase deficiency inhibits the useful in the management of of Clinical Endocrinology and permeability transition in mouse women with prelabour rupture of Metabolism 2010; in press. liver mitochondria. Endocrinology the membranes? Aust N Z J Obstet Nold MF, Nold-Petry CA, Zepp JA, Palmer 2010;151:1643-1652 Gynaecol. 2010 Dec;50(6):534-8. BE, Bufler P, Dinarello CA. IL-37 is Muircroft WM, McKimm J, William L et al. Nelson DR, Benhamou Y, Chuang WL, a fundamental inhibitor of innate A New Zealand Perspective on Lawitz EJ, Rodriguez-Torres M, Flisiak immunity. Nat Immunol November Palliative Care for Maori. Journal of R, Rasenack JW, Kryczka W, Lee CM, 2010;11(11):1014-22. Palliative Care 2010; 26(1):46-50. Bain VG, Pianko S, Patel K, Cronin Nold-Petry CA, Lehrnbecher T, Jarisch PW, Pulkstenis E, Subramanian GM, A, Schwabe D, Pfeilschifter JM, Muhl Murphy S, Lim R, Dickinson H, Acharya McHutchison JG; ACHIEVE-2/3 Study H, Nold MF. Failure of IFNto induce R, Rosli S, Jenkin G, Wallace EM. Team. Albinterferon alfa2b was not anti-inflammatory IL-18BP in familial Human amnion epithelial cells inferior to pegylated interferon in hemophagocytosis. PLoS One January prevent bleomycin-induced lung a randomized trial of patients with 2010;5(1):e8663. injury and preserve lung function. chronic hepatitis C virus genotype Cell Transplantation 2010 Nov 19. 2 or 3. Gastroenterology. 2010 [Epub ahead of print] Oct;139(4):1267-76. Epub 2010 Jul 1
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Norman S, Santamaria L, Biondi S. O’Connor DW, Gardner B, Presnell O’Driscoll DM, Horne RSC, Davey MJ, A case of orbital cellulitis with I, Singh D, Tsanglis M, White E. Walker AM, Nixon GM. Increased accompanying bilateral ptosis. The effectiveness of continuation- sympathetic activity in children Aust Orthoptic J 2010;42(1):18-20. maintenance ECT in reducing with obstructive sleep apnoea: depressed older patients’ hospital cardiovascular implications. Novakovic B, Wong NC, Sibson M, Ng re-admissions. Journal of Affective Sleep Medicine 2010; in press. HK, Morley R, Manuelpillai U, Down Disorders 2010;120(1):62-6. T, Rakyan VK, Beck S, Hiendleder Oakley E, Babl FE, Acworth J, Borland S, Roberts CT, Craig JM, Saffery R. O’Connor DW, Griffith J, McSweeney K. M, Kreiser D, Neutze J, Theophilos T, DNA methylation-mediated down- Changes to psychotropic medications Donath S, South M, Davidson A. The regulation of DNA methyltransferase-1 in the six months after admission to Paediatric Research in Emergency (DNMT1) is coincident with, but not nursing homes in Melbourne, Australia. Departments International Collaborative essential for, global hypomethylation International Psychogeriatrics 2010;22 (PREDICT). A prospective randomised in human placenta. J Biol Chem. (7):1149-53. trial comparing nasogastric with 2010;285(13):9583-93. intravenous hydration in children O’Connor DW, Parslow R. Apparent with bronchiolitis (protocol). The O’Callaghan C, Baron A, Barry P, Dun B. antidepressant over-prescribing to comparative rehydration in bronchiolitis Music’s relevance for pediatric cancer older Australians might reflect invalid study (CRIB). BMC Pediatrics 2010; patients: A constructivist and mosaic CIDI depression diagnoses. Australian 10:37. research approach. Supportive and New Zealand Journal of Psychiatry Care in Cancer 2010; DOI: 10.1007/ 2010;44(11):1052-3. Oakley, E. & Wong, AM. Ultrasound- s00520-010-0879-9. assisted peripheral vascular access O’Connor DW, Parslow R. Differences in in a paediatric ED. Emergency O’Callaghan, C., Hudson, P., older people’s responses to CIDI’s Medicine Australasia 2010;22(2): McDermott, F., Zalcberg, J. 2010 depression screening and diagnostic 166-170. ‘Music among family carers items may point to age-related of people with life-threatening bias. Journal of Affective Disorders O’Driscoll DM, Horne RS, Davey MJ, cancer’, Music and Medicine, doi: 2010;125(1):361-4. Hope SA, Walker AM, Nixon GM. The 10.1177/194380210390812 heart rate response to spontaneous O’Connor DW, Parslow R. Mental health arousal from sleep is reduced in O’Connell B, Gaskin CJ. Using an scales and psychiatric diagnoses: children with Down syndrome referred educational pamphlet to promote responses to GHQ-12, K-10 and CIDI for evaluation of sleep-disordered help-seeking behaviour for urinary across the lifespan. Journal of Affective breathing. Am J Physiol Heart Circ incontinence in people visiting their Disorders 2010;121(3):263-7. Physiol. 2010 Jun;298(6):H1986-90. general practitioner. Australian and New Zealand Continence Journal O’Connor DW, Sierakowski C, Chin LF, Oliver D, Healey F, Haines T. Preventing 2010; 16(2):8-12. Singh D. The safety and tolerability falls and fall-related injuries in of Clozapine in aged patients: a hospitals. Clinics in Geriatric Medicine. O’Connell B, Heslop L, Fennessy H. retrospective clinical file review. 2010;26(4):645-692 An Evaluation of a Wellness Guide World Journal of Biological Psychiatry for Older Carers Living in the 2010;11(6):788-91. Ong A, Quach H, Leech M. Reversal of Community. Public Health Nursing Transfusion dependence by tumour 2010; 27(4):302-9. O’Driscoll DM, Foster AM, Davey MJ, necrosis factor inhibitor in a patient with Nixon GM, Horne RS. Can actigraphy concurrent rheumatoid arthritis and O’Connor DW, Gardner B, Eppingstall measure sleep fragmentation primary myelofibrosis. Journal of Clinical B, Tofler D. Cognition in elderly in children? Arch Dis Child. Rheumatology. Accepted October 2010. patients after unilateral and bilateral 2010;95(12):1031-3. electroconvulsive therapy: a Ong BC, Stuckey S. Susceptibility prospective, naturalistic comparison. O’Driscoll DM, Horne RSC, Davey MJ, weighted imaging: a pictorial review. Journal of Affective Disorders 2010; Hope SA, Walker AM, Nixon GM. The J Med Imaging Radiant Oncol. 2010 124(3):235-40. Heart Rate Response to Spontaneous Oct;54(5):435-49. Arousal from Sleep is Reduced in O’Connor DW, Gardner B, Presnell I, Children with Down Syndrome Referred Ooi JD, Kitching AR, Holdsworth SR. Singh D, Tsanglis M, White E. for Evaluation of Sleep Disordered Review: T helper 17 cells: their role Continuation-maintenance ECT: Breathing. Am J Physiol Heart Circ in glomerulonephritis. Nephrology quality standards in three Australian Physiol. 2010 298(6):H1986-90 (Carlton). 2010 Aug;15(5):513-21. aged psychiatry services. Journal of ECT 2010;26(2):95-7.
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Osama Elsewaisy, Barry Slon, John Pan D, Tay Y, Appu S, Frydenberg M. Patterson SJ, George J, Strasser SI, Lee Monagle. Analgesic Effect of Are we providing enough urology AU, Sievert W, Nicoll AJ, Desmond Subanaesthetic Intravenous Ketamine teaching? A cross sectional survey. PV, Roberts SK, Locarnini S, Bowden in Refractory Neuropathic Pain: BJU International 2010; 105:22 S, Angus PW. Tenofovir disoproxil A Case Report. Pain Medicine fumarate rescue therapy following 2010;11:946-50. Pao AC, Bhargava A, Di Sole F, Quigley R, failure of both lamivudine and adefovir Shao XL, Wang JA, Thomas S, Zhang dipivoxil in chronic hepatitis B. Gut. Ostaszkiewicz J, Hornby L, Millar L, JN, Shi MJ, Funder JW, Moe OW, 2011 Feb;60(2):247-54. Ockerby C. The Effects of Conservative Pearce D. Expression and role of serum Treatment for Constipation on and glucocorticoid-regulated kinase 2 Paule SG, Airey LM, Li Y, Stephens AN, Symptom Severity and Quality of in the regulation of Na+/H+ exchanger Nie GY. Proteomic approach identifies Life in Community-Dwelling Adults. 3 in the mammalian kidney. American alterations in cytoskeletal remodelling Journal of Wound, Ostomy & Journal of Physiology-Renal Physiology proteins during decidualization of Continence Nursing. 2010; 37(2):193-8. 2010;299:F1496-F1506 human endometrial stromal cells. Journal of Proteome Research Padiglione A, Aleksic E, French M, Arnott A, Pashaiasl M, Khodadadi K, Holland MK, 2010;9:5739-5747 Wilson KM, Tippett E, Kaye M, Gray L, Verma PJ. The efficient generation Ellett A, Crane M, Leslie DE, Lewin SR, of cell lines from bovine parthenotes. Pedchenko V, Bondar O, Fogo AB, Breschkin A, Birch C, Gorry PR, McPhee Cell Reprogram. 2010;12(5):571-9. Vanacore R, Voziyan P, Kitching AR, DA, Crowe SM. Extremely prolonged Wieslander J, Kashtan C, Borza DB, HIV seroconversion associated with Pasricha SR, Flecknoe-Brown SC, Allen Neilson EG, Wilson CB, Hudson an MHC haplotype carrying disease KJ, Gibson PR, McMahon LP, Olynyk BG. Molecular architecture of the susceptibility genes for antibody JK, Roger SD, Savoia HF, Tampi R, Goodpasture autoantigen in anti-GBM deficiency disorders. Clin Immunol. Thomson AR, Wood EM, Robinson KL. nephritis. N Engl J Med. 2010 Jul 2010 Nov;137(2):199-208. Epub Diagnosis and management of iron 22;363(4):343-54. 2010 Aug 8. deficiency anaemia: a clinical update. Med J Aust. 2010 Nov 1;193(9):525-32. Peeters M, Price TJ, Cervantes A, Sobrero Page M, Nandurkar D, Crossett MP, AF, Ducreux M, Hotko Y, Andre T, Chan Stuckey SL, Lau KP, Kenning N, Troupis Passier L, Nascimento M, Gesch J, Haines E, Lordick F, Punt CJA, Strickland AH, JM. Comparison of 4 cm Z-axis and 16 T. Physiotherapist observation of head Wilson G, Ciuleanu TE, Roman L, cm Z-axis multidetector CT perfusion. and neck alignment. Physiotherapy Cutsem EV, Tzekova V, Collins S, Oliner Eur Radiol. 2010 Jun;20(6):1508-14 Theory and Practice 2010; 26 (6): KS, Rong A, Gansert J. Randomized Epub 2009 Dec 16. 416-423. phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan Patil S, Coutsouvelis J, Spencer A. Palermo C, Hughes R, McCall L. A (FOLFIRI) compared with FOLFIRI Asparaginase in the management of qualitative evaluation of an Australian alone as second-line treatment in adult acute lymphoblastic leukaemia: public health nutrition workforce patients with metastatic colorectal Is it used appropriately? Cancer development intervention involving cancer. Journal of Clinical Oncology Treatment Reviews (in press). mentoring circles. Public Health Nutr. 2010; 28:4706-4670. 2010 Sep 21:1-8. Patil S, Wei A, Avery S, Spencer A. Pellicano R, Strauss BJ, Polkinghorne KR, Reduced intensity conditioned Palermo C, Hughes R, McCall L. An Kerr PG. Body composition in home allogeneic haematopoietic stem cell evaluation of a public health nutrition haemodialysis versus conventional transplantation results in durable workforce development intervention haemodialysis: a cross-sectional, disease free and overall survival in for the nutrition and dietetics workforce. matched, comparative study. Nephrol patients with poor prognosis myeloid J Hum Nutr Diet. 2010 Jun;23(3): Dial Transplant 2010; 25:568-73. 244-53. and lymphoid malignancies: eighty month follow up. Bone Marrow Petta CA, Peloggia A, Salamonsen L, Palmer K, Delpachitra P, Onwude J, Transplant 2010,45;1154-1160. de Angelo Andrade L, Zhang J, Rombauts L, Meagher S, Tong S. Bahamondes L. Natural killer cells Patten, Scott B, Gordon-Brown, Lee, Association between twin discordance and telomerase in the endometrium Meadows, Graham. Simulation at 6-9 weeks’ of gestation and of patients with endometriosis. Journal studies of age-specific lifetime birthweight complications. Twins of Endometriosis 2010;2:182-188 Research and Human Genetics major depression prevalence. 2010:13(4):389-92. BMC Psychiatry. 2010; 10:1-16
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Pham Y, Tu Y, Wu T, Allen TJ, Calkin AC, Polizzotto MN, Jones P, Cameron PU, Prasad SB, Fahrtash F, Malaiapan Y, Watson AM, Li J, Jandeleit-Dahm Spelman D, Woolley IJ. The Influence Meredith IT, Cameron J. Obesity and KA, Toh BH, Cao Z, Cooper ME, of Splenectomy on the Infectious the metabolic syndrome in patients Chai Z. Cell division autoantigen 1 Complications and Outcomes of people with acute myocardial infarction. Int J plays a profibrotic role by modulating With HIV: Marked, Sustained Elevation Cardiol. 2010 Oct 29;144(3):450-1. downstream signalling of TGF- in Risk of Severe Infection With Bacteria beta in a murine diabetic model of Including Streptococcus pneumoniae. Prasad SB, Fahrtash F, Malaiapan atherosclerosis. Diabetologia. 2010 J Acquir Immune Defic Syndr. 2010 Y, Meredith IT, Cameron J. Jan;53(1):170-9. Nov 1;55(3):e24-e26. 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St John JC, Facucho-Oliveira J, Jiang Stephens A, Pereira-Fantini PM, Wilson Streitberg George S., Bwititi Phillip, Angel Y, Kelly R, Salah R. Mitochondrial GJ, Taylor RG, Rainczuk A, Meehan Lyndall, Sikaris Kenneth A. Automation DNA transmission, replication and K, Thomas S, Sourial M, Fuller PJ, and Expert Systems in a Core Clinical inheritance: a journey from the gamete Stanton PG, Robertson DM and Chemistry Laboratory. JALA 2009; through the embryo and into offspring Bines JE. Proteomic analysis of the 14(2): 94-105. ***This paper won the and embryonic stem cells. Hum intestinal adaptation response reveals JALA Reader’s Choice Award for 2009 Reprod Update. 2010;16(5):488-509. altered expression of fatty acid binding proteins following massive small Strunk T, Power MR, Currie A, Philbin Staf K, Dwyer PL, Rosamilia A, Lee J. bowel resection. Journal of Proteome V, Golenbock D, Otto M, Simmer K, Long-term outcomes of patients who Research 2010; 9:1437–1449. Doherty D, Richmond P, Burgner D, failed to attend following midurethral Levy O. TLR2 mediates recognition of sling surgery – A competitive study Stephens AN, Hannan NJ, Rainczuk A, live Staphylococcus epidermidis and and analysis of risk factors for Meehan KL, Chen J, Nicholls PK, clearance of bacteremia. PLoS ONE non-attendance. Aust & New Zealand Rombauts LJ, Stanton PG, Robertson 2010 5(4): e10111. doi:10.1371/journal. Journal of Obstetrics & Gynaecology DM, Salamonsen LA. Post-translational pone.0010111. 2010, 50 (2): 173-178 modifications and protein-specific isoforms in endometriosis revealed Stuart R, Bradford J, Leszkiewicz P, Wilson Stav K, Dwyer P, Rosamilia A, Schierlitz by 2D DIGE. J Proteome Res. 2010; J, Gillespie E. The cost of containing L, Lim YN, Lee J. Midurethral 9(5):2438-49. measles within a healthcare service. sling procedures for stress urinary Healthcare Infection 2010;15:43-46 incontinence in women over 80 years. Stephens AN, Pereira-Fantini PM, Wilson Neurourology and Urodynamics. G, Taylor RG, Rainczuk A, Meehan Stuart RL, Tan K, Mahar JE, Kirkwood CD, 2010, 29 (7): 1262-1266 KL, Sourial M, Fuller PJ, Stanton PG, Ramsden CA, Andrianopoulos N, Jolley Robertson DM, Bines JE. Proteomic D, Bawden K, Doherty R, Kotsanas D, Stav K, Dwyer PL, Rosamilia A, Schierlitz L, analysis of the intestinal adaptation Bradford J, Buttery JP. An outbreak of Lim UN, Chao F, De Souza A, Thomas response reveals altered expression Necrotizing Enterocolitis Associated E, Murray C, Conway C, Lee J. Repeat of fatty acid binding proteins following with Norovirus Genotype GII.3. PIDJ synthetic mid urethral sling procedure massive small bowel resection. 2010; 29: 644-647 for women with recurrent stress urinary Journal of Proteome Research 2010; Stuckey S. Radiology Images. Intern Med J incontinence. Journal of Urology Jan 9:1437-1449 2010, 183 (1): 241-246 2010 Dec;40(12):868. 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Activin A regulates trophoblast cell 119(2):167-76. Factor ROR{gamma}t Promotes adhesive properties: implications for Glomerulonephritis. J Am Soc Nephrol. implantation failure in women with Summers SA, Hoi A, Steinmetz OM, 2010 Dec 23. endometriosis-associated infertility. O’Sullivan KM, Ooi JD, Odobasic D, Hum Reprod. 2010;25(7):1767-74. Stenger MR, Rose MJ, Joshi MS, Rogers Akira S, Kitching AR, Holdsworth SR. TLR9 and TLR4 are required for the LK, Chicoine LG, Bauer JA, Nelin Stokes IC, Downie PA, Wood EM, development of autoimmunity and LD. Inhaled nitric oxide prevents Bowden DK, Monagle PT Barnes lupus nephritis in pristane nephropathy. 3-nitrotyrosine formation in the lungs CD. Hyperhaemolysis in sickle cell J Autoimmun. 2010 Dec;35(4):291-8. of neonatal mice exposed to >95% disease – an unusual and potentially oxygen. Lung. 2010;188(3):217-27. life threatening complication. Med J Summers SA, Steinmetz OM, Gan PY, Aust 2010; Mar 1;192(5);281-2 Stenvers KL, Findlay JK. Inhibins: from Ooi JD, Odobasic D, Kitching A, Holdsworth SR. TLR2 induces Th17 reproductive hormones to tumor Strahl B, Cheung YK, Stuckey SL. myeloperoxidase autoimmunity, while suppressors. Trends in Endocrinology Diagnostic yield of computed TLR9 drives Th1 autoimmunity. Arthritis and Metabolism 2010;21:174-180 tomography of the brain in first episode Rheum. 2010 Dec 28. psychosis. J Med Imaging Radiant Oncol. 2010 Oct;54(5):431-4.
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Summers SA, Steinmetz OM, Ooi JD, Gan Swan MP, Moore GT, Sievert W, Devonshire Tannast M, Pleus F, Bonel HM, Galloway PY, O’Sullivan KM, Visvanathan K, Akira DA. Efficacy and safety of single- H, Siebenrock K, Anderson SE. MRI S, Kitching AR, Holdsworth SR. Toll-like session argon plasma coagulation in in traumatic posterior hip dislocation. receptor 9 enhances nephritogenic the management of chronic radiation Journal of Orthop Research 2010 immunity and glomerular leukocyte proctitis. Gastrointest Endosc. 2010 Dec;24(12):723-31. recruitment, exacerbating experimental Jul;72(1):150-4. crescentic glomerulonephritis. Am J Tapp RJ, O’Neil A, Shaw JE, Zimmet PZ, Pathol. 2010 Nov;177(5):2234-44. Taffe JR, Cain KC, Mitchell ES, Woods Oldenburg BF; AusDiab Study Group. NF, Crawford SL, & Harlow SD. Is there a link between components of Summers SA, Steinmetz, OM, Gan, PY, et “Persistence” improves the 60-day health-related functioning and incident al. TLR2 induces Th17 myeloperoxidase amenorrhea marker of entry to late- impaired glucose metabolism and type autoimmunity, while TLR9 drives Th1 stage menopausal transition for women 2 diabetes? The Australian Diabetes autoimmunity. Arthritis Rheum 2010. aged 40 to 44 years. Menopause, Obesity and Lifestyle (AusDiab) study. 2010;17(1), 191-193. doi: 10.1097/ Diabetes Care. 2010 Apr;33(4):757-62. Summers SA, Steinmetz, OM, Ooi, JD, gme.0b013e3181b5540e et al. Toll-like receptor 9 enhances Tat PA, Sumer H, Jones KL, Upton K, nephritogenic immunity and Tan K, Baxter G, Newell S, Smye S, Dear Verma PJ. The efficient generation glomerular leukocyte recruitment, P, Brownlee K, Darling J. Knowledge of induced pluripotent stem (iPS) exacerbating experimental crescentic elicitation for validation of a neonatal cells from adult mouse adipose glomerulonephritis. Am J Pathol 2010; ventilation expert system utilising tissue-derived and neural stem cells. 177: 2234-2244. modified Delphi and focus group Cell Transplant. 2010;19(5):525-36. techniques. Int J of Human-Comp Summers SA, van der Veen BS, O’Sullivan Stud 2010; 68 (6): 344-354. Tebbutt NC, Cummins MM, Sourjina T, KM, Gan PY, Ooi JD, Heeringa P, Strickland A, van Hazel G, Ganju Satchell SC, Mathieson PW, Saleem Tan K, Sehgal A, O’Heney J, Sacks B, V, Gibbs D, Stockler M, Gebski V, MA, Visvanathan K, Holdsworth Ramsden A. Sildenafil citrate for Zalchberg. Randomized, SR, Kitching AR. Intrinsic renal pulmonary hypertension in newborn non-comparative phase II study of cell and leukocyte-derived TLR4 infants. Acta Pædiatrica 2010, 98 weekly docetaxel with cisplatin and aggravate experimental anti-MPO (Suppl. 460), p.245. 5-Flourouracil or with capecitabine glomerulonephritis. Kidney Int. 2010 in oesophagastric cancer: the Dec;78(12):1263-74. Epub 2010 Tan ZY, Naidoo P, Kenning N. Case of the AGITG ATTAX trial. 2010. On behalf Sep 15. month. Ultrasound and MRI features of the Australasian Gastro-Intestinal of connatal cysts: clinicoradiological Trials Group. Sun Q, Zang WJ, Chen C. Growth hormone differentiation from other supratentorial secretagogues reduce transient periventricular cystic lesions. Br J Radiol Tebbutt NC, Wilson K, Gebski VJ, outward K+ current via phospholipase 2010 Feb; 83(986):180-3. Cummins MM, Zannino D, van Hazel C/protein kinase C signaling pathway in GA, Robinson B, Broad A, Ganju V, rat ventricular myocytes. Endocrinology Tang AL, Walker KZ, Wilcox G, Strauss Ackland SP, Forgeson G, Cunningham 2010;151:1228-1235 BJ, Ashton JF, Stojanovska L. Calcium D, Saunders MP, Stockler MR, Chua absorption in Australian osteopenic Y, Zalcberg JR, Simes J, Price TJ. Sundaramurthy SR, Wilson G, Moshinsky post-menopausal women: an acute Capecitabine, bavacizumab and RA, Smith JA. Compensatory lung comparative study of fortified soymilk mitomycin in first-line treatment of hypertrophy following pneumonectomy. to cows’ milk. Asia Pac J Clin Nutr. metastatic colorectal cancer: results of Heart Lung Circulation 2010;19:430. 2010;19(2):243-9. the Australasian Gastrointestinal Trials Group randomized phase III MAX study. Sunil Badve, Fiona Brown, Carmel Hawley, Tang AL, Wilcox G, Walker KZ, Shah NP, Journal of Clinical Oncology. Published David W Johnson, John Kanellis, Ashton JF, Stojanovska L. Phytase ahead of print on line on 01 June 2010. Gopala Rangan, and Vlado Perkovic. activity from Lactobacillus spp. in Challenges and feasibility of conducting calcium-fortified soymilk. J Food Sci. Tebruegge M, Connell T, Ritz N, Bryant a trial of uric acid lowering therapy in 2010 Aug 1;75(6):M373-6. PA, Curtis N. Discordance between chronic kidney disease. Nature Reviews TSTs and IFN-gamma release assays: Tang BC, Fu J, Watkins DN, Hanes J. Nephrology 2010 -071V1B. the role of NTM and the relevance of Enhanced efficacy of local etoposide mycobacterial sensitins. Eur Respir J Swan MP, Moore G, Sievert W, Devonshire delivery by poly(ether-anhydride) 2010; Jul;36(1):214-5. DA. Efficacy and safety of single particles against small cell lung cancer session argon plasma coagulation in in vivo. Biomaterials. 2010;31(2): Teede H, Meyer C, Hutchison S, Zoungas the management of chronic radiation 339-44. S, McGrath B, Moran L. Endothelial proctitis. Gastrointestinal Endoscopy function and insulin resistance in 2010; 72:150–154 Polycystic Ovary Syndrome: The effects of medical therapy. Fertility & Sterility 2010; 93:184-91.
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Teede H, Renouf D, Jayasuriya I, Barrie D. Thai WE, Harper RW, Seneviratne S. Thrift AG, Evans RG, Kalyanram K, Kartik STOP fracture study: Southern Health Dynamic volume 320-slice CT in the K, Fitzgerald SM, Srikanth V. Gender- osteoporotic fracture screening project. assessment of patent ductus arteriosus specific effects of caste and salt on Internal Medicine Journal 2010. doi: for percutaneous closure. Heart. 2010 hypertension in poverty: a population- 10.1111/j.1445-5994.2010.02258.x. Feb;96(4):321. based study. J Hypertens. 2010 (epub) Nov 26. Teede HJ, Deeks A, Moran LJ. Polycystic Thai WE, Meredith IT, Mottram PM. Acute ovary syndrome: A complex condition coronary syndrome in a patient with Thrift AG, Srikanth V, Evans RG. How with psychological, reproductive and a large inter-communicating coronary generalisable is INTERSTROKE? metabolic manifestations that impacts vascular malformation: imaging with Lancet. 2010 Nov 6;376(9752):1538-9; on health across the lifespan. BMC 320-slice CT. Postgrad Med J. 2010 author reply 9. Medicine 2010;8:41. Jul;86(1017):445. Thrift AG, Srikanth V, Fitzgerald SM, Teede HJ, Lombard C, Deeks AA. Thai WE, Meredith IT, Seneviratne S. Kalyanram K, Kartik K, Hoppe CC, Obesity, metabolic complications and Complex bifurcation left main coronary Walker KZ, Evans RG. Potential roles the menopause: An opportunity for artery in-stent restenosis diagnosed of high salt intake and maternal prevention. Climacteric 2010;13(3): with dynamic volume 320-slice malnutrition in the development 203-209. computed tomography. Heart Lung of hypertension in disadvantaged Circ. 2010 Nov;19(11):684-6. populations. Clin Exp Pharmacol Teede HJ, Meyer C, Hutchison SK, Physiol. 2010 Feb;37(2):e78-90. Zoungas S, McGrath B, Moran LJ. Thomas D, Das SK, Levine JA, Martin CK, Endothelial function and insulin Mayer L, McDougall A, Strauss BJ, Tinsley RB, Kotschet K, Ng H, Prince resistance in polycystic ovary Heymsfield SB. New fat free mass - fat M Peinert S, Quach H, Horne MH, syndrome: The effects of medical mass model for use in physiological Shaw G, Nagley P. The plasma level of therapy. Fertility and Sterility energy balance equations. Nutr Metab α-synuclein is correlated with the risk 2010;93(1):184-191. (Lond). 2010;7:39. and clinical phenotype of Parkinson’s disease. Annals Neurol. Accepted Teh P, Grigoriadis G, Salem H. Case report: Thompson AJ, Nguyen T, Iser D, Ayres Nov 2010 Acquired Factor V inhibitor. Int Med J. A, Jackson K, Littlejohn M, Slavin J, 2010(40): 667. Bowden S, Gane EJ, Abbott W, Lau GK, Tiruvoipati R, Ong K, Gangopadhyay H, Lewin SR, Visvanathan K, Desmond PV, Arora S, Carney I, Botha J. Hypothermia Tesch G, Amur S, Schousboe JT, Siegel JN, Locarnini SA. Serum hepatitis B surface predicts mortality in critically ill elderly Lesko LJ, Bai JPF. Successes Achieved antigen and hepatitis B e antigen titres: patients with sepsis. BMC Geriatrics and Challenges Ahead in Translating disease phase influences correlation 2010; 10:70. Biomarkers into Clinical Applications. with viral load and intrahepatic hepatitis AAPS Journal 2010; 12(3):243-253. B virus markers. Hepatology. 2010 Toh BH, Chan J, Kyaw T, Alderuccio F. Jun;51(6):1933-44. Cutting Edge Issues in Autoimmune Tesch GH, Lim AKH. Recent insights Gastritis. Clin Rev Allergy Immunol. into diabetic renal injury from the db/ Thomsen HS, Morcos SK, Almen T, Aspelin 2010 Dec 22. db mouse model of type 2 diabetic P, Bellin MF, Clement O, Heinz-Peer nephropathy. Am J Physiol Renal Physiol G, Reimer P, Stacul F, van der Molen Toh BH, Taylor R, Pollock W, Dearden S, (Epub 8/12/2010) AJ, Webb JA. Metformin and contrast Gill CC, Buchner C, Burlingame RW. media. Radiology 2010 Aug;256(2): ‘Actin-reactive’ discriminated from Tesch GH. Macrophages and diabetic 672-3. ‘non-actin-reactive’ smooth muscle nephropathy. Semin Nephrol. 2010 autoantibody by immunofluorescence May;30(3):290-301. Thorup J, McLachlan R, Cortes D, Nation reactivity with rat epithelial cell line. TR, Balic A, Southwell BR, Hutson Pathology. 2010;42(5):463-9. Tesch GH. Serum and Urine Biomarkers of JM. What is new in cryptorchidism Kidney Disease: a pathophysiological and hypospadias-a critical review on Toussaint N, Lau K, Stauss B, Polkinghorne perspective. Nephrology (Carlton) 2010; the testicular dysgenesis hypothesis. K, Kerr P. Effect of Alendronate on 15: 609-616. Journal of Pediatric Surgery 2010; Vascular Calcification in CKD Stages 3 and 4: A Pilot Randomized Controlled Testro AG, Gow PJ, Angus PW, 45:2074-2086 Trial. American Journal of Kidney Wongseelashote S, Skinner N, Threadgate M, McCahy P, Frydenberg Diseases 2010 July;56(1);57-68. Markovska V, Visvanathan K. Effects M. A retrospective review of radical of antibiotics on expression and prostatectomy in a Victorian tertiary Toussaint N, Lau K, Stauss B, Polkinghorne function of Toll-like receptors 2 and 4 referral centre. BJU International 2010; K, Kerr P. Using vertebral bone on mononuclear cells in patients with 105 S1 18. densitometry to determine aortic advanced cirrhosis. J Hepatol. 2010 calcification in patients with chronic Feb;52(2):199-205. Epub 2009 Dec 16. kidney disease. Nephrology 2010 August; 15(5):575-583.
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Toussaint ND, Elder GJ, Kerr PG. Tu Y, Wu T, Dai A, Pham Y, Chew P, Haan Veldman A, Fischer D, Wong FY, Kreuz W, A rational guide to preventing JB, Wang Y, Toh BH, Zhu H, Cao Z, Sasse M, Eberspächer B, et al. Human fracture risk in dialysis patients. Cooper ME, Chai Z. Cell division Protein C concentrate in the treatment Semin Dial. 2010; 23(1):43-54. autoantigen 1 enhances signaling of Purpura Fulminans: A retrospective and the profibrotic effects of analysis of safety and outcome in 94 Toussaint ND, Lau KK, Strauss BJ, transforming growth factor-beta in pediatric patients. Critical Care 2010 Polkinghorne KR, Kerr PG. Effect of diabetic nephropathy. Kidney Int. 14:R156. alendronate on vascular calcification 2011 Jan;79(2):199-209. in chronic kidney disease stages 3-4 - Veldman A, Santamaria-Araujo JA, a pilot randomized controlled trial. Vaddadi, Krishna. Rehabilitation psychiatry: Sollazzo S, Pitt J, Yaplito-Lee J, Gianello Am J Kidney Dis 2010; 56(1):57-68. Moving forward. 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The study protocol of a blinded haemodialysis patients: barrier analysis randomised controlled crossover Verginis N, Davey MJ, Horne RSC. Scoring for implementing better practice. trial of lavender oil as a treatment of respiratory events in paediatric patients: Nephrol Dial Transplant. 2010 Oct 8. behavioural symptoms in dementia. evaluation of nasal pressure compared BMC Geriatrics 2010;10:49. with thermister recordings. Sleep Toussaint ND, Pedagogos E, Lau KK, Medicine 2010; April 11(4):400-5. Heinze S, Becker GJ, Beavis J, Van Doornum S, Brand C, Sundararajan V, Polkinghorne KR, Damasiewicz MJ, Kerr Ajani AE, Wicks IP. Rheumatoid arthritis Villagonzalo KA, Dodd S, Dean O, Gray K, PG. Lateral lumbar X-ray assessment patients receive less frequent acute Tonge B, & Berk M. Oxidative pathways of abdominal aortic calcification in reperfusion and secondary prevention as a drug target for the treatment of Australian haemodialysis patients. therapy after myocardial infarction autism. 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Walker EC, McGregor NE, Poulton IJ, Truby H, Baxter KA, Barrett P, Ware RS, Solano M, Pompolo S, Fernandes TJ, Cardinal JC, Davies PS, Daniels LA, Vasireddy RS, Sprung CN, Cempaka Constable MJ, Nicholson GC, Zhang Batch JA. The Eat Smart Study: a NL, Chao M, McKay MJ. H2AX JG, Nicola NA, Gillespie MT, Martin randomised controlled trial of a reduced phosphorylation screen of cells from TJ, Sims NA. Oncostatin M promotes carbohydrate versus a low fat diet for radiosensitive cancer patients reveals bone formation independently of weight loss in obese adolescents. a novel DNA double-strand break resorption when signaling through BMC Public Health. 2010;10:464. repair cellular phenotype. Br J Cancer. leukemia inhibitory factor receptor in 2010;102(10):1511-8. mice. Journal of Clinical Investigation Truby H. Internationalism in dietetic 2010;120:582-592 education and practise. J Hum Nutr Veldman A, Fischer D, Nold MF, Wong Diet. 2010 Jun;23(3):203-4. FY. 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Walker KZ, Woods J, Ross J, Hechtman Ward S. Being mindful of mind and Wee JL, Chionh YT, Ng GZ, Harbour SN, R. Yoghurt and dairy snacks presented memory medications. GeriatricMedicine Allison C, Pagel CN, Mackie EJ, Mitchell for sale to an Australian consumer: are in General Practice 2010;7:12. HM, Ferrero RL, Sutton P. Protease- they becoming less healthy? Public activated receptor-1 down-regulates Health Nutr. 2010 Jul;13(7):1036-41. Warrier SK,Thomas SS, Kumar B, Hastie I. the murine inflammatory and humoral Stomal melanoma - myth or reality? response to Helicobacter pylori. Wallace AB, Goergen SK, Schick D, Int J Colorectal Dis 2010;26(3):391-2. Gastroenterology. 2010;138(2):573-82. Soblusky T, Jolley D. Multidetector CT dose: clinical practice improvement Waseda K, Ako J, Yamasaki M, Koizumi Wei A and Teh T. Salvaging AML with strategies from a successful T, Ormiston J, Worthley SG, Whitbourn CLAG: novel option, or more of optimization program. J Am Coll RJ, Walters DL, Honda Y, Meredith the same? Accepted Leukemia Radiol. 2010 Aug;7(8):614-24. IT, Fitzgerald PJ; RESOLUTE Trial Research. DOI information: 10.1016/j. Investigators. Short and mid-term leukres.2010.10.015 Wallace EM, Tringali MD. Identification intravascular ultrasound analysis of of a novel member in the family the new zotarolimus-eluting stent Wei J, Waithman J, Lata R, Mifsud NA, Albulidae (bonefishes). J Fish Biol. with durable polymer - results from Cebon J, Kay T, Smyth MJ, Sadler AJ, 2010 May;76(8):1972-83. the RESOLUTE trial. Circ J. 2010 Chen W. Influenza A infection enhances Oct;74(10):2097-102. cross-priming of CD8+ T cells to Walter LM, Rogers PA, Girling JE. cell-associated antigens in a TLR7- Differential expression of vascular Waxman BP. A stroke of luck or just the and type I IFN-dependent fashion. endothelial growth factor-A isoforms ideal model of care? Med J Aust. 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Williams BRG. Differentiating the interferon Wu IC, Lai CL, Han SH, Han KH, Gordon Yiallourou SR, Sands SA, Walker AM, pathway. Cell Cycle. 2010;9(17):3400. SC, Chao YC, Tan CK, Sievert W, Horne RS. Postnatal development Tanwandee T, Xu D, Neo BL, Chang TT. of baroreflex sensitivity in infancy. Williams HL, Tunbull I, Thomas SJ, Murphy Efficacy of entecavir in chronic hepatitis J Physiol. 2010;588(Pt 12):2193-203. A, Stinear T, Armstrong DS, Whitchurch B patients with mildly elevated alanine CB. A diagnostic PCR assay for the aminotransferase and biopsy-proven Yim D, Ramsay J, Kothari D, Burgner D. detection of an Australian epidemic histological damage. Hepatology. Coronary artery dilatation in toxic strain of Pseudomonas aeruginosa. 2010 Apr;51(4):1185-9. shock-like syndrome: The Kawasaki Ann Clin Microbiol Antimicrob 2010 disease shock syndrome. Pediatr Jul 16;9:18 Xiang B, Liu JX, Sung HB, Yan B, Cheng W. Cardiol 2010; Aug 13. [Epub ahead The effect of CO2 pneumovesicum of print]. 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Determining Zhang W, Zeng X, Briggs KJ, Beaty R, Yorkston SM, Walker AM, Horne RSC. sleep quality in children with sleep Simons B, Chiu Yen RW, Tyler MA, Cerebral oxygenation is depressed disordered breathing: EEG spectral Tsai HC, Ye Y, Gesell GS, Herman JG, during sleep in healthy term infants analysis compared with conventional Baylin SB, Watkins DN. A potential when they sleep prone. Pediatrics polysomnography. Sleep 2010 tumor suppressor role for Hic1 in 2011;127:e558-565. Sept;33(9):1165-72. breast cancer through transcriptional repression of ephrin-A1. Oncogene. Wong J, Zoungas S, Wright C, Teede Yang YH, Ngo D, Jones M, Simpson 2010;29(17):2467-76. H. Evidence based guidelines for E, Fritzemeier KH, Morand EF. perioperative management of diabetes Endogenous estrogen regulation of Zhao YF, Wang L, Lee S, Sun Q, Tuo Y, in cardiac and vascular surgery. World inflammatory arthritis and cytokine Wang YM, Pei JM, Chen C. Cholesterol Journal of Surgery 2010;34(3):500-13. expression in male mice, predominantly induces mitochondrial dysfunction via estrogen receptor alpha. Arthritis and apoptosis in mouse pancreatic Woodland L, Burgner D, Paxton G, Zwi K. Rheum. 2010 Apr;62(4):1017-25. beta-cell line MIN6 cells. Endocrine Health service delivery for newly arrived Journal 2010;37:76-82 refugee children: A framework for good Yap J, Salamonsen LA, Jobling T, Nicholls practice. J Paediatr Child Health 2010; PK, Dimitriadis E. Interleukin 11 is Zhong Y, Shirinzadeh B, Smith JA, Gu C. Jul 7. [Epub ahead of print]. upregulated in uterine lavage and Thermal-mechanical based soft tissue endometrial cancer cells in women with deformation for surgery simulation. Workman B, Dickson F, Green S. Early endometrial carcinoma. Reproductive Advanced Robotics 2010;24:1719-39. dementia. Optimal management in Biology and Endocrinology 2010;8:63 general practice. Australian Family Physician 2010;39(10):722-6.
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Zoghi M, Brown T, Williams B, Roller L, BOOK CHAPTERS Favilla, M. 2010. Eye and Orbital Injury. Jaberzadeh S, Palermo C, McKenna In: Smith JA, Fox JG, Saunder AC, Yii L, Wright C, Baird M, Schneider-Kolsky MK (eds) Hunt & Marshall’s Clinical Allan CA, Bannerjee M, Wu FCW. M, Hewitt L, Sim J, Holt TA. Learning Problems in Surgery. 2nd Ed. Churchill Androgens and Coronary Artery style preferences of Australian health Livingstone, Sydney. pp439-447. Disease. In ENDOTEXT - Endocrinology science students. J Allied Health. 2010 of Male Reproduction 2010 Summer;39(2):95-103. Feil SC, Polekhina G, Gorman MA, http://www.endotext.org/male/ Parker MW. 2010. Proteins: membrane Zoungas S, Chalmers J, Kengne AP, male16/maleframe16.htm binding and pore formation. In: Pillai A, Billot L, de Galan B, Marre Lakey GAJ (ed) Adv Exp Med Biol. Allan CA, McLachlan RI 2010 Androgen M, Neal B, Harrap S, Poulter N, Patel Springer Science+Business Media, Deficiency Disorders. In: Endocrinology, A. The efficacy of lowering glycated LLC, New York, USA. pp1-13. 6th edition. Eds: Jameson JL, DeGroot haemoglobin with a gliclazide modified LJ. Saunders Elsevier, Philadelphia, release-based intensive glucose Fuller PJ 2010 Aldosterone: Secretion p.2514-2543 lowering regimen in the ADVANCE and Action. In: ‘Endocrinology’, 6th edition. Eds Jameson JL, DeGroot trial. Diabetes Research and Clinical Ames D, Chiu E, O’Connor D, LJ. Saunders Elsevier, Philadelphia, Practice. 2010 Aug;89(2):126-33. Lautenschlager N. Old Age Psychiatry. p.1831-1838 In: Castle DJ, Bassett D (eds). Zoungas S, Lui M, Kerr PG, Teede H, A Primer of Clinical Psychiatry. Elsevier McNeil JJ, McGrath BP, Polkinghorne Gargett CE. 2010. Stem cells of the human Press, Sydney. 2010:pp234-245. KR. Advanced chronic kidney disease, uterus: derivation, characterisation and uses of endometrial stem cells. cardiovascular events and the effect of Chin WN, Lynch C, Frydenberg M. 2010. In: Bongso A, Lee EH (eds) Stem cells: diabetes: Data from the ASFAST study. Urology. In: Phelps K & Hassed C From Bench to Bedside. 2nd Ed. Internal Medicine Journal 2010. doi: (eds) General Practice: The Integrative World Scientific Publishing, New Jersey, 10.1111/j.1445-5994. Approach. Elsevier: Churchill London, Singapore. pp583-609. Livingstone, Sydney. pp658-677. Zoungas S, Patel A, Chalmers J, de Gargett CE, Guo S-W. 2010. Stem cells Galan BE, Li Q, Billot L, Woodward Clarke DM. Demoralizzazione. In Maj M, and clonality in endometriosis. In: M, Ninomiya T, Neal B, MacMahon Maggini C, Siracusano A. Lessico di Garcia-Velasco JA, Rizk BR (eds) S, Grobbee DE, Kengne AP, Marre Psicopatologia. Il pensiero scientifico Endometriosis - Current Management M, Heller S; ADVANCE Collaborative editore, Roma 2010, pp129-132. and Future Trends. 1st Ed. Jaypee Group. Severe hypoglycemia and [Italian]. risks of vascular events and death. Brothers Medical Publishers (P) Ltd, The New England Journal of Medicine. Crozier TRA, 2010 Problems in Surgical St Louis, USA. pp307-16. 2010 Oct 7;363(15):1410-8. Intensive Care. In: Smith JA, Fox JG, Giles ML, Audsley J, Lewin SR. Saunder AC, Yii MK,(eds) Hunt & Lamivudine. In: Grayson ML, Crowe Marshall’s Clinical Problems in Surgery. SM, McCarthy JS, Mills J, Mouton JW, 2nd Edition. Elsevier. Churchill and Norrby SR, Paterson DL, Pfaller MA. Livingston Australia, pp390-403 (eds). Kucers’ The Use of Antibiotics De Kretser D, Burger HG 2010 Gonadal (6th ed.). American Society for Peptides: Inhibins, Activins, Follistatin, Microbiology & Hodder Arnold, 2010. Mullerian-Inhibiting Substance Gray KM, Brereton AV, & Tonge BJ. (Antimullerian Hormone). In: Autism. In N. Davies (Ed.), Chiropractic ‘Endocrinology’, 6th edition. Eds: paediatrics: A clinical handbook Jameson JL, DeGroot LJ. Saunders (2nd ed., pp. 207-216). 2010 Elsevier, Philadelphia, p.2118-2133 Edinburgh: Churchill Livingstone. Dowling C, Frydenberg M. 2010. Guymer E and Littlejohn G O. Management Urogenital problems. In: Smith JA. of Fibromyalgia. In: Muscle Pain: Fox JG, Saunder AC, Yii MK (eds) Diagnosis and Treatment, Eds S Mense Hunt & Marshall’s Clinical Problems in and R Gerwin, DOI 10.1007/978-3- Surgery, 2nd Edition, Elsevier: Churchill 642-05468-6_5, Springer-Verlag Berlin Livingstone, Sydney. pp328-348. Heidelberg 2010, pp105-142.
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Hedger MP. 2010. Immunology of the Johnson PDR, Korman TM. Littlejohn G O. Gender, genetics, and other testis and male reproductive tract. In: Nontuberculous mycobacterial risk factors increasing vulnerability to McQueen CA (ed) Comprehensive infection, including leprosy. In: Yung fibromyalgia. In: Muscle Pain: Diagnosis Toxicology. 2nd Ed. Elsevier, San Diego, A, Spelman DW, Street A. Johnson and Treatment, Eds S Mense and R USA. pp189-230. PDR, Sorrell T, McCormack J. (eds.) Gerwin, DOI 10.1007/978-3-642-05468- Infectious Diseases: A Clinical Approach 6_5, Springer-Verlag Berlin Heidelberg Hoare BJ, Imms C. (2010). Getting (3rd ed.), IP Communications, 2010. 2010, pp143-157. Ready for School. In K. Dodd, C. Imms, N. Taylor (Eds.), Physical and Kaparakis M, Allison CC, Hutton ML, Lynch L, Hancox K, Happell B. The state Occupational Therapy for Cerebral Ferrero RL. 2010. Innate immune of the science and clinical supervision Palsy (pp. 130-145), London: inititators and effectors in Helicobacter in Australia and New Zealand. In: McKeith Press. pylori infection. In: Sutton P, Mitchell Cutcliffe JR, Hyrkäs K, & Fowler J, HM (eds) Helicobacter pylori in the 21st editors. Routledge handbook of clinical Holdsworth SR and Tipping PG. 2010. Century. CAB International. pp142-66. supervision: Fundamental international Pathways of cellular adaptive themes. New York: Routledge; 2011: immunity in autoimmune crescentic King PT. Bronchiectasis. In Respiratory pp 317-26 glomerulonephritis and lupus nephritis. Infections Ed Sethi S. Lung Health and In: Lupus nephritis, 2nd edition. Editors Biology Series. Informa, New York 2010: Lynch L, Happell B, Hancox K. Introducing EJ Lewis, MM Schwartz, SM Korbet, 61-85 clinical supervision in a rural health care DT Mao. Oxford University Press, organisation: An Australian experience. pp 103-128. King PT. The Respiratory Oxidative In: Cutcliffe JR, Hyrkäs K, & Fowler J, Burst and its Clinical Manifestations. editors. Routledge handbook of clinical Jenkin G, Johnson P, Street A. Fever and In Neutrophils, Lifespan, Functions supervision: Fundamental international upper respiratory tract symptoms. and Role in Disease. Ed Franco JD. themes. New York: Routledge; 2011. In: Yung A. Spelman DW. Street A. Novascience Publishing, New York, pp163-74 Johnson PDR. Sorrell T. McCormack 2010, 145-54 J. (eds.) Infectious Diseases: A Martin TJ, Sims NA, Quinn JM 2010 Clinical Approach (3rd ed.), IP Korman TM. Ethambutol. In: Grayson Interactions among osteoblasts, Communications, 2010. ML, Crowe SM, McCarthy JS, Mills J, osteoclast and other cells in bone. Mouton JW, Norrby SR, Paterson DL, In: ‘Osteoimmunology: Interactions of Jenkin GA. Isoniazid. In: Grayson ML, Pfaller MA. (eds). Kucers’ The Use of the Immune and Skeletal Systems’. Crowe SM, McCarthy JS, Mills J, Antibiotics (6th ed.). American Society Eds: Lorenzo J, Choi Y, Horowitz M, Mouton JW, Norrby SR, Paterson DL, for Microbiology & Hodder Arnold, Takayanagi H. Academic Press, Pfaller MA. (eds). Kucers’ The Use 2010. p.228-267 of Antibiotics (6th ed.). American Society for Microbiology & Hodder Korman TM. Rifabutin. In: Grayson ML, Meyer ADMcR, Parkinson JEL. Emergency Arnold, 2010. Crowe SM, McCarthy JS, Mills J, Contraception. In: Cameron (eds) Mouton JW, Norrby SR, Paterson DL, Paediatric Emergency Medicine (Ed. 2) Jenkin GA. Pyrazinamide. In: Grayson Pfaller MA. (eds). Kucers’ The Use 2010. Churchill Livingston Publications. ML, Crowe SM, McCarthy JS, of Antibiotics (6th ed.). American Mills J, Mouton JW, Norrby SR, Society for Microbiology & Hodder Moss TJ, Baldwin DN, Allison BJ, Pillow Paterson DL, Pfaller MA. (eds). Kucers’ Arnold, 2010. JJ. 2010. Anatomy and physics The Use of Antibiotics (6th ed.). of respiration. In: Splinter R (ed) American Society for Microbiology & Lim J, Waxman BP, Favilla M. 2010. Handbook of Physics in Medicine Hodder Arnold, 2010. Problems in the injured patient. In: and Biology. CRC Press, London, Hunt and Marshall’s Clinical Problems New York. pp1-20. Jenkin GA. Rifapentine. In: Grayson in Surgery. 2nd Edition, Eds. Smith, ML, Crowe SM, McCarthy JS, Fox, Saunder & Yii, Elsevier, Australia, Murphy S, Rosli S, Acharya R, Mathias Mills J, Mouton JW, Norrby SR, Chapter 13 pps.404-476. L, Lim R, Wallace E, Jenkin G. 2010. Paterson DL, Pfaller MA. (eds). Kucers’ Amnion epithelial cell isolation and The Use of Antibiotics (6th ed.). Littlejohn G O. Diffuse Idiopathic Skeletal characterization for clinical use. In: American Society for Microbiology & Hyperostosis. In: Rheumatology, 5nd Elefanty A, Gregory R, Patient R, Hodder Arnold, 2010. Edition, Eds. Hochberg MC, Silman AJ, Schlaeger T, Snyder E, Yamashita Y Smolen JS, Weinblatt ME, Weisman (eds) Curr Protoc Stem Cell Biol. MH. , Mosby, London, 2010, pp John Wiley & Sons, Inc. pp1-25. 1801-1806, ISBN 978-0-323-06551-1.
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Murphy S, Wallace E, Jenkin G. 2010. Street AC, Korman TM. Rifampicin. In: BOOKS Placental-derived stem cells: potential Grayson ML, Crowe SM, McCarthy clinical applications. In: Appasani JS, Mills J, Mouton JW, Norrby SR, O’Connell B, Crowe J, Gilbee A, Johnson K, Appasani RK (eds) Stem Cells & Paterson DL, Pfaller MA. (eds). Kucers’ S, Ockerby C, Ostaszkiewicz J, Regerative Medicine: From Molecular The Use of Antibiotics (6th ed.). Russell V, Smith TR, Sukkar K, Tran Embryology to Tissue Engineering. American Society for Microbiology & C. 2011. The Tri-focal Model of Care: 1st Ed. Humana Press, Springer Hodder Arnold, 2010. Introduction. In Tri-focal Model of Care Science & Business Media, New York, Education Program for Residential USA. pp243-63. Stuart RL. Moxifloxacin. In: Grayson ML, Crowe SM, McCarthy JS, Mills J, Aged Care. Deakin University, Australia. O’Connor D. Prevalence and incidence Mouton JW, Norrby SR, Paterson DL, ISBN: 978 1 74156 150 0. of dementia. In: Burns A, Ames D, Pfaller MA. (eds). Kucers’ The Use O’Connell B, Crowe J, Gilbee A, Johnson O’Brien J (eds). Dementia, 4th Ed. of Antibiotics (6th ed.). American S, Ockerby C, Ostaszkiewicz J, Russell Arnold Health Sciences, London, Society for Microbiology & Hodder V, Smith TR, Sukkar K, Tran C. 2011. 2010:pp22-30. Arnold, 2010. The Tri-focal Model of Care: Collegiality Ojaimi S, Korman TM. Rifaximin. In: Stuart RL. Norfloxacin. In: Grayson ML, and Teamwork. In Tri-focal Model of Grayson ML, Crowe SM, McCarthy Crowe SM, McCarthy JS, Mills J, Care Education Program for Residential JS, Mills J, Mouton JW, Norrby SR, Mouton JW, Norrby SR, Paterson DL, Aged Care. Deakin University, Australia. Paterson DL, Pfaller MA. (eds). Kucers’ Pfaller MA. (eds). Kucers’ The Use ISBN: 978 1 74156 149 4. The Use of Antibiotics (6th ed.). of Antibiotics (6th ed.) American O’Connell B, Crowe J, Gilbee A, Johnson American Society for Microbiology & Society for Microbiology & Hodder S, Ockerby C, Ostaszkiewicz J, Russell Hodder Arnold, 2010. Arnold, 2010. V, Smith TR, Sukkar K, Tran C. 2011. Padiglione AA, McDonald MM, Yung Stuart RL. Sitaifloxacin. In: Grayson ML, The Tri-focal Model of Care: Introducing A. Infections in the elderly. In: Yung Crowe SM, McCarthy JS, Mills J, Evidence-Based Practice Through A, Spelman DW, Street A. Johnson Mouton JW, Norrby SR, Paterson Change Management and Leadership. PDR, Sorrell T, McCormack J. (eds.) DL, Pfaller MA. (eds). Kucers’ The In Tri-focal Model of Care Education Infectious Diseases: A Clinical Approach Use of Antibiotics (6th ed.). American Program for Residential Aged Care. (3rd ed.), IP Communications, 2010. Society for Microbiology & Hodder Deakin University, Australia. Arnold, 2010. ISBN: 978 1 74156 151 7 Richards M, Stuart RL, Ferguson J. Infections associated with healthcare. Taggart DA, Schultz DJ, Fletcher TP, O’Connell B, Crowe J, Gilbee A, Johnson In: Yung A, Spelman DW, Street A. Friend JA, Smith IG, Breed WG, S, Ockerby C, Ostaszkiewicz J, Johnson PDR, Sorrell T, McCormack J. Temple-Smith PD. 2010. Cross- Russell V, Smith TR, Sukkar K, Tran (eds.) Infectious Diseases: fostering and short-term pouch young C. 2011. The Tri-focal Model of Care: A Clinical Approach (3rd ed.), isolation in macropodoid marsupials: Management of Behaviours of Concern. IP Communications, 2010. implications for conservation and In Tri-focal Model of Care Education species management. In: Coulson Program for Residential Aged Care. Smith JA, Yii MK. Preoperative medical G, Eldridge M (eds) Macropods: The Deakin University, Australia. problems in surgical patients. In: Smith Biology of Kangaroos, Wallabies and ISBN: 978 1 74156 156 2 JA, Fox JG, Saunder AC, Yii MK (Eds). Rat-Kangaroos. CSIRO Publishing, O’Connell B, Crowe J, Gilbee A, Johnson Hunt & Marshall’s Clinical Problems Victoria, Australia. pp263-76. in Surgery. Elsevier Australia, Sydney S, Ockerby C, Ostaszkiewicz J, 2010. ISBN 978-0-7295-3826-8. Thrift AG, Srikanth V. Epidemiology and Russell V, Smith TR, Sukkar K, Tran Pathology of Stroke. In: Brocklehurst C. 2011. The Tri-focal Model of Care: Smith JA. Chest and chest wall problems. Text Book of Geriatric Medicine 2010 Management of Continence. In In: Smith JA, Fox JG, Saunder AC, Yii 7th ed., 478-483. Eds. Rockwood, Tri-focal Model of Care Education MK (Eds). Hunt & Marshall’s Clinical Fillit et al. Program for Residential Aged Care. Problems in Surgery. Elsevier Australia, Deakin University, Australia. ISBN: Sydney 2010. ISBN 978-0-7295-3826-8. Wolfe C, Visvanathan K. Rheumatic 978 1 74156 155 5 Fever. In: Cohen J, Powderly WG, Srikanth V, Phan TG. Stroke – Clinical Opal SM. Infectious Diseases O’Connell B, Crowe J, Gilbee A, Johnson Presentation, Management and (3rd ed.), Mosby, 2010. S, Ockerby C, Ostaszkiewicz J, Organisation of Services. In: Russell V, Smith TR, Sukkar K, Tran Brocklehurst Text Book of Geriatric C. 2011. The Tri-focal Model of Care: Medicine 2010 7th ed., 484-497 Management of Depression. In Eds. Rockwood, Fillit et al. Tri-focal Model of Care Education Program for Residential Aged Care. Deakin University, Australia. ISBN: 978 1 74156 154 8.
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O’Connell B, Crowe J, Gilbee A, Johnson S, Ockerby C, Ostaszkiewicz J, Russell V, Smith TR, Sukkar K, Tran C. 2011. The Tri-focal Model of Care: Management of Medication. In Tri-focal Model of Care Education Program for Residential Aged Care. Deakin University, Australia. ISBN: 978 1 74156 157 9
O’Connell B, Crowe J, Gilbee A, Johnson S, Ockerby C, Ostaszkiewicz J, Russell V, Smith TR, Sukkar K, Tran C. 2011. The Tri-focal Model of Care: Management of Mobility. In Tri-focal Model of Care Education Program for Residential Aged Care. Deakin University, Australia. ISBN: 978 1 74156 153 1.
O’Connell B, Crowe J, Gilbee A, Johnson S, Ockerby C, Ostaszkiewicz J, Russell V, Smith TR, Sukkar K, Tran C. 2011. The Tri-focal Model of Care: Management of Nutrition and Hydration. In Tri-focal Model of Care Education Program for Residential Aged Care. Deakin University, Australia. ISBN: 978 1 74156 152 4.
Smith JA, Fox JG, Saunder AS, Yii MK (Eds). Hunt and Marshall’s Clinical Problems in Surgery. Elsevier Australia, Sydney, 2010.ISBN 978-0-7295-3826-8.
Srivastava, R. 2010. Tell me the truth: Conversations with my patients about life and death. Penguin Books Australia. ISBN – 13: 9780670074402.
156 Southern Health Research Report 2010 157 COLLABORATIONSSOUTHERN AND HEALTH PARTNERSHIPS AND MHTP PUBLICATIONS
A partnership between Southern Health, Prince Henry’s Institute, Monash Institute of Medical Research and Monash University translating scientific discoveries into world’s best healthcare.
Southern Health has established the Deakin- Southern Health Nursing Research Centre. Deakin University is nationally and internationally recognised as a centre of excellence in nursing research in the areas of quality, safety and risk management.
Southern Health is a member of the Victorian Cancer Biobank, which is a not-for-profit consortium of tissue banks supported by Cancer Council Victoria and the Victorian Government. The aim is to provide researchers with high quality tissue samples and data to facilitate cancer research discoveries.
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Cancer Trials Australia is a network of oncology trial centres and Southern Health is a member. Units at the Monash Medical Centre Moorabbin and Clayton campuses participate in multisite trials contracted by Cancer Trials Australia, with pharmaceutical and biotech companies, thereby providing access to new investigational agents.
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